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Journal articles on the topic 'Pregnane analogues'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Slavíková, Barbora, Alexander Kasal, Hana Chodounská та Zdena Krištofíková. "3α-Fluoro Analogues of "Allopregnanolone" and Their Binding to GABAA Receptors". Collection of Czechoslovak Chemical Communications 67, № 1 (2002): 30–46. http://dx.doi.org/10.1135/cccc20020030.

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(Diethylamino)sulfur trifluoride (DAST) was used for the preparation of 3α-fluorides (e.g., 3α-fluoro-5α-pregnane-12,20-dione, 3α-fluoro-16α-[(methoxycarbonyl)methyl]-5α-pregnan-20-one, methyl 3α-fluoro-5α-androstane-17β-carboxylate, 3α-fluoro-5β-pregnan-20-one) from the corresponding 3β-alcohols and for the preparation of 3,3-difluorides from 3-ketones (e.g., 3,3-difluoro-5α-pregnan-20-one). Boron trifluoride etherate was used for the conversion of an epoxide into 3α-fluoro-2β-hydroxy-5α-pregnan-20-one. The in vitro binding of the 3α-fluorides and the corresponding 3α-alcohols to the GABAA re

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2

Kohout, Ladislav, Alexander Kasal, and Miroslav Strnad. "Pregnane-Type Brassinosteroids with a Four-Carbon Ester Functionality in Position 20." Collection of Czechoslovak Chemical Communications 61, no. 6 (1996): 930–40. http://dx.doi.org/10.1135/cccc19960930.

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Analogues of brassinolide and castasterone, containing an ester functionality with four carbon atoms in the position 20 of the pregnane skeleton, have been prepared. In the bean second internode assay the most effective compounds were (20R)-2α,3α,20-trihydroxy-5α-pregnan-6-one 20-isobutyrate (6d) and (20R)-2α,3α,20-trihydroxy-B-homo-7-oxa-5α-pregnan-6-one 20-isobutyrate (7d). On the other hand, (20R)-2α,3α,20-trihydroxy-B-homo-6-oxa-5α-pregnan-7-one 20-heptafluorobutyrate (8) was the first compound with the retarding effect in the same test.

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3

Rivera, Daniel G., and Francisco Coll. "Synthesis and preliminary bioactivity evaluation of new pregnane brassinosteroid-like compounds." Canadian Journal of Chemistry 83, no. 8 (2005): 1084–92. http://dx.doi.org/10.1139/v05-051.

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Seven new pregnane compounds bearing some representative A- and B-ring brassinosteroid functions, as well as hydrogen bond donor and acceptor ones on the D ring, were efficiently synthesized. The obtained compounds did not show remarkable plant growth-promoting activity in the radish hypocotyl elongation and cotyledon expansion bioassays, however, introducing oxygen and amino functions on the D ring led to an enhancement of the bioactivity. The 16β-functionalized pregnane brassinosteroid-like compounds were slightly more active than the 16α-functionalized ones.Key words: steroids, brassinoster

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4

Sui, Yipeng, Ni Ai, Se-Hyung Park, et al. "Bisphenol A and Its Analogues Activate Human Pregnane X Receptor." Environmental Health Perspectives 120, no. 3 (2012): 399–405. http://dx.doi.org/10.1289/ehp.1104426.

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5

Kohout, Ladislav, and Miroslav Strnad. "Brassinosteroids with Ester Function with Five Carbon Atoms at the 20 Position." Collection of Czechoslovak Chemical Communications 57, no. 8 (1992): 1731–38. http://dx.doi.org/10.1135/cccc19921731.

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Pregnane analogues of brassinolide and castasterone have been prepared which have an ester function with five carbon atoms at the 20 position. When tested by the bean second internode bioassay, the most efficient substance is VIII.

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6

Murayama, Eigoro, Katsuhito Miyamoto, Kiyoshige Ochi, and Noboru Kubodera. "Synthesis and immunoregulating activity of vitamin D analogues bearing pregnane side chains." Bioorganic & Medicinal Chemistry Letters 2, no. 10 (1992): 1289–92. http://dx.doi.org/10.1016/s0960-894x(00)80232-2.

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7

Shao, Yuting, Yan Zhao, Hong Zhang, et al. "A New Immunosuppressive Pregnane Glycoside and Two Known Analogues from Epigynum cochinchinensis." Natural Product Communications 13, no. 6 (2018): 1934578X1801300. http://dx.doi.org/10.1177/1934578x1801300604.

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Phytochemical investigation of the ethyl acetate soluble fraction from the leaves of Epigynum cochinchinensis led to the isolation of one new C21 pregnane glycoside, epigycoside C (1), along with two known analogues epigycoside A (2) and epigynoside G (3). Their structures were elucidated on the basis of extensive spectroscopic techniques. The in vitro immunosuppressive activity of compound 1 was evaluated against concanavalin A (Con A)- and lipopolysaccharides (LPS)-stimulated proliferation of mice splenocytes. Compound 1 displayed significant immunosuppressive activities in a dose-dependent

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8

Rivera, Daniel G., Francisco Coll, and Fredy León. "Synthesis of pregnane ketols as metabolic precurs ors of analogues of plant growth regulators." Journal of Chemical Research 2004, no. 4 (2004): 284–85. http://dx.doi.org/10.3184/0308234041209239.

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9

Lau, Aik Jiang, and Thomas K. H. Chang. "3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease." Pharmacological Research 100 (October 2015): 64–72. http://dx.doi.org/10.1016/j.phrs.2015.07.031.

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10

Melin, P., J. Trojnar, B. Johansson, H. Vilhardt, and M. Åkerlund. "Synthetic antagonists of the myometrial response to vasopressin and oxytocin." Journal of Endocrinology 111, no. 1 (1986): 125–31. http://dx.doi.org/10.1677/joe.0.1110125.

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ABSTRACT With the aim of developing inhibitors of vasopressin-and oxytocin-induced uterine activity, 17 analogues of 1-deamino-oxytocin were synthesized by the solid-phase method. Modifications were made at positions 2, O-methyltyrosine (Tyr(OMe)) and O-ethyltyrosine (Tyr(OEt)),d-Tyr,d-Tyr(OEt),d-Trp; 4, Val,Thr and 8, Orn,Cit,Arg,d-Arg. The analogues were tested for antiuterotonic activity in vitro and in vivo in the rat and in vitro on myometrial strips from non-pregnant women and pregnant women at term. Their selectivity was also investigated in blood pressure and antidiuretic bioassays in

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11

Peter Wipf, Haibiao Gong, Jelena M. Janjic, Song Li, Billy W. Day, and Wen Xie. "New Opportunities for Pregnane X Receptor (PXR) Targeting in Drug Development. Lessons from Enantio- and Species-Specific PXR Ligands Identified from A Discovery Library of Amino Acid Analogues." Mini-Reviews in Medicinal Chemistry 7, no. 6 (2007): 617–25. http://dx.doi.org/10.2174/138955707780859404.

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12

Negrato, Carlos Antonio, Renan Magalhães Montenegro Junior, Lilia Maria Von Kostrisch, Maria Fatima Guedes, Rosiane Mattar, and Marilia B. Gomes. "Insulin analogues in the treatment of diabetes in pregnancy." Arquivos Brasileiros de Endocrinologia & Metabologia 56, no. 7 (2012): 405–14. http://dx.doi.org/10.1590/s0004-27302012000700001.

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Pregnancy affects both maternal and fetal metabolism, and even in non-diabetic women, it exerts a diabetogenic effect. Among pregnant women, 2% to 14% develop gestational diabetes. Pregnancy can also occur in women with preexisting diabetes, which may predispose the fetus to many alterations in organogenesis, restrict growth, and the mother, to some diabetes-related complications, such as retinopathy and nephropathy, or to acceleration of the course of these complications, if they are already present. Women with gestational diabetes generally start their treatment with diet and lifestyle chang

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13

Rizwan, Razia, Mohsana Tariq, Sahreen Anwar, and Raheela Kanwal. "POSTERIOR PELVIC PAIN." Professional Medical Journal 25, no. 12 (2018): 1823–27. http://dx.doi.org/10.29309/tpmj/18.4924.

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Background: Pregnancy related posterior pelvic pain (PRPPP) is a common complaint among pregnant females. It is one of main source for disability, absence from work and is responsible for direct and indirect economical impact. Purpose of the Study: To investigate the prevalence of pregnancy associated posterior pelvic pain and to ascertain its occurrence in three trimesters of pregnancy. Study Design: Cross sectional survey. Setting: District Head Quarter Hospital Sargodha & Gynae OPDs of different clinics. Period: Jan 2013 to Dec 2013. Materials and Methods: 200 pregnant females, the rang

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14

Paris, Jason J., and Cheryl A. Frye. "Estrous cycle, pregnancy, and parity enhance performance of rats in object recognition or object placement tasks." REPRODUCTION 136, no. 1 (2008): 105–15. http://dx.doi.org/10.1530/rep-07-0512.

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Ovarian hormone elevations are associated with enhanced learning/memory. During behavioral estrus or pregnancy, progestins, such as progesterone (P4) and its metabolite 5α-pregnan-3α-ol-20-one (3α,5α-THP), are elevated due, in part, to corpora luteal and placental secretion. During ‘pseudopregnancy’, the induction of corpora luteal functioning results in a hormonal milieu analogous to pregnancy, which ceases after about 12 days, due to the lack of placental formation. Multiparity is also associated with enhanced learning/memory, perhaps due to prior steroid exposure during pregnancy. Given evi

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15

Baxter, R. C., A. M. Suikkari, and J. L. Martin. "Characterization of the binding defect in insulin-like growth factor binding protein-3 from pregnancy serum." Biochemical Journal 294, no. 3 (1993): 847–52. http://dx.doi.org/10.1042/bj2940847.

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During pregnancy, insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) undergoes proteolysis, rendering it undetectable by radioligand binding techniques. This study examines the physical and functional defect in pregnancy IGFBP-3. Ternary complex formation has been measured by the binding of the acid-labile subunit of the circulating IGFBP-3 complex, which also requires IGF-I or IGF-II binding. IGF-depleted pregnancy IGFBP-3, prepared by size-exclusion chromatography at low pH, could not form a ternary complex in the presence of [Tyr60]IGF-I or of an IGF-I analogue extensively altered

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16

Lucas, C., L. N. Bald, M. C. Martin, et al. "An enzyme-linked immunosorbent assay to study human relaxin in human pregnancy and in pregnant rhesus monkeys." Journal of Endocrinology 120, no. 3 (1989): 449–57. http://dx.doi.org/10.1677/joe.0.1200449.

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ABSTRACT A sensitive and specific double-antibody enzyme-linked immunoassay, using a synthetic analogue of human relaxin for standard and immunogen, was developed for the measurement of human relaxin (hRLX) in serum and plasma. No cross-reactivity was observed for human insulin, human insulin-like growth factor-I, hGH, human chorionic gonadotropin, hFSH, hLH or human prolactin. The assay was used to monitor RLX concentrations in samples from men, non-pregnant and pregnant women, and in pregnant rhesus monkeys infused with hRLX. RLX was not detected in serum from men nor from non-pregnant women

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17

Sun, Xiaojun, Chengwei Wang, Bian Wang, et al. "Efficacy of Nucleotide/Nucleoside Analogues and Hepatitis B Immunoglobulin Therapy in Blocking Mother-to-Child Transmission of Hepatitis B in an Eastern Chinese Group." Infectious Diseases in Obstetrics and Gynecology 2020 (December 17, 2020): 1–4. http://dx.doi.org/10.1155/2020/4305950.

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The objective of this study was to investigate the efficacy and potential side-effects of nucleotide/nucleoside analogues and hepatitis B immunoglobulin injection of newborns in blocking mother-to-child transmission of hepatitis B virus in the middle and late pregnancy period. 238 cases of enrolled pregnant women were divided into the Telbivudine group, the Tenofovir group, the Lamivudine group, and the hepatitis B immunoglobulin (HBIG) group. Enrolled patients received corresponding therapies. Clinical and laboratory data were collected. Results showed that the levels of HBV DNA of the enroll

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18

Carlsson, L., S. Edén, and J. O. Jansson. "The plasma pattern of growth hormone in conscious rats during late pregnancy." Journal of Endocrinology 124, no. 2 (1990): 191–98. http://dx.doi.org/10.1677/joe.0.1240191.

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ABSTRACT The plasma GH levels of female rats during late pregnancy were determined using an automatic method for repetitive blood sampling from conscious animals. The plasma GH patterns were analysed by a pulse analysis computer program (PULSAR). The mean plasma GH levels were about twofold higher in pregnant females on days 15, 18 and 22 of gestation than in age-matched non-pregnant females. The basal plasma GH levels were also increased, while there was no change in GH pulse amplitude or frequency. The augmentation of GH release was even more pronounced on day 20 of gestation, with a fourfol

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19

Losonczy, G., J. P. Singh, M. Schoenl, I. Mucha, and R. C. Venuto. "Pregnancy enhances the pressor response to thromboxane analogues in rabbits." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 269, no. 3 (1995): R720—R725. http://dx.doi.org/10.1152/ajpregu.1995.269.3.r720.

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In this study, we first tested the hypothesis that the previously demonstrated circulatory failure and thrombocytopenia induced by intracaval administration of thromboxane A2 (TxA2) analogues in nonpregnant (NP) rabbits [G. Losonczy, I. Mucha, J. DiPirro, J. Sweeney, G. Brown, J. Brentjens, and R. Venuto. Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 34): R772-R780, 1993] could be avoided if the compounds were given instead into the aortic arch. Conscious New Zealand White rabbits received bolus injections of U-46619 (5-20 micrograms) through a previously implanted catheter thread

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20

Maskey, Sean. "Teenage Pregnancy: Doubts, Uncertainties and Psychiatric Disturbance." Journal of the Royal Society of Medicine 84, no. 12 (1991): 723–25. http://dx.doi.org/10.1177/014107689108401210.

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Fifty-two pregnant teenagers were assessed at ‘booking’ using the General Health Questionnaire (GHQ 28), a locus of control scale, and five visual analogue ‘attitude scales’. Thirty-eight were in the antenatal and 14 in the termination clinic. One quarter had probable psychiatric disorder on the GHQ. The GHQ scores correlated significantly with indecision about the planned outcome of pregnancy (whether termination or full term). Locus of control correlated with the Depression scale of the GHQ but not with attitude to pregnancy or choice of termination or delivery. Clinic staff should be alert

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21

Luque, E. M., V. P. Carlini, L. M. Vincenti, et al. "Effects of hexarelin (a ghrelin analogue) on fertilisation and the pre- and postnatal development of mice." Reproduction, Fertility and Development 22, no. 6 (2010): 926. http://dx.doi.org/10.1071/rd09231.

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Ghrelin (Ghr) has been associated with reproductive physiology and pre- and postnatal development. The objectives of the present study were to evaluate the effects of hexarelin (HEX; 100 or 200 µg kg−1 day−1), a therapeutic Ghr analogue, on: (1) embryo development 60 h post ovulation, induced pharmacologically, in pregnant mice; (2) the physical, neurobiological and sexual development of offspring of female mice injected with HEX during the first, second or third week of pregnancy or throughout the entire pregnancy; and (3) adult memory acquisition in these offspring. We also evaluated the eff

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22

Bastian, S. E. P., P. E. Walton, J. C. Wallace, and F. J. Ballard. "Plasma clearance and tissue distribution of labelled insulin-like growth factor-I (IGF-I) and an analogue LR3IGF-I in pregnant rats." Journal of Endocrinology 138, no. 2 (1993): 327–36. http://dx.doi.org/10.1677/joe.0.1380327.

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ABSTRACT To determine whether the changes in insulin-like growth factor-binding proteins (IGFBPs) and IGF-I levels during pregnancy in rats affect the clearance of IGFs from the circulation, we have measured pharmacokinetic parameters and the tissue distribution of radiolabelled IGF-I and LR3IGF-I, a potent analogue which has a markedly reduced affinity of binding to the IGFBPs. Intravenous boluses of radiolabelled growth factors were administered to catheterized virgin and age-matched pregnant rats on day 18 of gestation when plasma IGFBPs, in particular IGFBP-3, are dramatically reduced. IGF

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23

Bayraktar, Zeki, Şerife Tuğba Kahraman, Elif Seçkin Alaç, İrem Yengel, and Deniz Sarıkaya Kalkan. "Maternal hydronephrosis in pregnant women without ureteral stones and characteristics of symptomatic cases who need treatment: A single-center prospective study with 1026 pregnant women." Archivio Italiano di Urologia e Andrologia 93, no. 1 (2021): 35–41. http://dx.doi.org/10.4081/aiua.2021.1.35.

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Purpose: The aim of this study is to determine the proportion of maternal hydronephrosis and symptomatic cases requiring treatment in pregnant women without ureteral stones and the characteristics of these cases. Materials and methods: Between February 2018 and April 2019, all pregnant women followed for pregnancy in obstetrics and outpatient policlinic were evaluated prospectively. Maternal hydronephrosis rate, degree of hydronephrosis and side, symptomatic hydronephrosis rate, maximum renal anteroposterior diameter of renal pelvis and visual analogue scale were detected. Symptomatic patients

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24

Bryndal, Aleksandra, Marian Majchrzycki, Agnieszka Grochulska, Sebastian Glowinski, and Agnieszka Seremak-Mrozikiewicz. "Risk Factors Associated with Low Back Pain among A Group of 1510 Pregnant Women." Journal of Personalized Medicine 10, no. 2 (2020): 51. http://dx.doi.org/10.3390/jpm10020051.

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Background: Low Back Pain (LBP) is a frequent, very common, and costly health problem. LBP, which occurs during pregnancy, may become a lifelong problem. The aim of this study was to determine the risk factors associated with LBP in pregnant women. Methods: The study included 1510 pregnant women. A questionnaire assessing demography, lifestyle, prevalence, and characteristics was designed and used in the study. Pain intensity was assessed with the VAS (Visual Analogue Scale). The RMDQ (Roland Morris Disability Questionnaire) was used to assess the effect that low back pain had on the functiona

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25

Fasunla, Ayotunde James, Ukamaka Nwankwo, Paul Adekunle Onakoya, Adesina Oladokun, and Onyekwere George Nwaorgu. "Gustatory Function of Pregnant and Nonpregnant Women in a Tertiary Health Institution." Ear, Nose & Throat Journal 98, no. 3 (2019): 143–48. http://dx.doi.org/10.1177/0145561319833914.

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Physiological changes in pregnancy may cause taste dysfunction. The aim of this study was to determine and compare gustatory function of pregnant women with nonpregnant women and also to investigate the effect of pregnancy on gustatory function. It was a case–control study of consecutive 70 healthy pregnant women (cases) and 70 healthy nonpregnant women (control). Participants scored their taste perception on a visual analogue scale (1-10) and their gustatory function was assessed using “taste strips” impregnated with graded concentration of sweet, sour, salty, and bitter taste substances appl

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26

Sulaiman, Karina, Madhavilatha Vuppali, and Kenneth Abreo. "Patient Outcome in Pregnancy Requiring Dialysis: A Case Series." Open Urology & Nephrology Journal 7, no. 1 (2014): 52–55. http://dx.doi.org/10.2174/1874303x01407010052.

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The optimal management of pregnant dialysis patients remains a great challenge for nephrologists, end-stage renal disease being a predictor of adverse outcomes in this condition. We report a single-center experience of four patients requiring dialysis during pregnancy, all of which resulted in successful delivery of viable infants. Our success rate may reflect an overall improvement in management of this population, with special attention paid to multiple risk factors. These include blood pressure and volume control, anemia management with erythropoietin analogues, nutritional intake and total

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27

Kapamadzija, Aleksandra, Jelka Vukelic, Artur Bjelica, and Vesna Kopitovic. "Medical abortion: Modern method for termination of pregnancy." Medical review 63, no. 1-2 (2010): 63–67. http://dx.doi.org/10.2298/mpns1002063k.

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Introduction. Modern methods of medically induced abortions are being used in many countries all over the world. These methods are safe and effective when used in an appropriate way. Drugs used for medical abortion. The most widely used regimens for drug induced abortions include antiprogestogen mifepriston followed by administration of a synthetic prostaglandin analogue - gemeprost vaginally or misoprostol orally or vaginally. When used for abortions up to 9 and 7 weeks of pregnancy, this method has efficacy up to 98%. The regimen between 9 and 12 completed weeks is still under investigation.

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28

Mitchell, Jeanette, Donnèe Ness, and Sandra Whitelock. "Low back pain in pregnancy: A comparative study of two pain-rating scales." South African Journal of Physiotherapy 48, no. 3 (1992): 33–35. http://dx.doi.org/10.4102/sajp.v48i3.735.

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A sample of ten pregnant Caucasian women, with an average age of 31,8 ±5,7 years, experiencing low back pain in the third trimester of pregnancy, rated the intensity of their pain on two commonly used pain rating scales: the horizontal visual analogue scale (VAS) and the eight-face pictorial pain scale (PPS). A mean of 3,1 ±2,5 cms was found using the VAS and a mean of 5(E) was obtained on the PPS. A product-moment correlation of the two scales showed a correlation of 0,84 (p = 0,001). This implies that both pain rating scales are able to measure a similar intensity of low back pain in pregnan

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29

Szostek, Arnika, Jakub Wydra, Izabella Czajka-Oraniec, and Wojciech Zgliczyński. "Two successful pregnancies in a woman with active acromegaly." Wiedza Medyczna 2, no. 2 (2020): 72–76. http://dx.doi.org/10.36553/wm.60.

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Acromegaly is a rare systemic disease, predominantly caused by growth hormone (GH)-secreting pituitary adenoma, leading to insulin-like growth factor-1 (IGF-1) overproduction. Pituitary adenoma extension and/or its treatment can cause infertility or subfertility in both sexes in different mechanisms. Pregnancies in women with active acromegaly are rarely observed but considered generally safe. Growth hormone and IGF-1 concentrations are usually stable during pregnancy and in most cases no significant tumour expansion emerges despite pharmacological therapy withdrawal. A 28 year-old woman

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30

Arkinstall, S. J., and C. T. Jones. "Influence of pregnancy on G-protein coupling to adenylate cyclase activation in guinea-pig myometrium." Journal of Endocrinology 127, no. 1 (1990): 15–21. http://dx.doi.org/10.1677/joe.0.1270015.

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ABSTRACT The regulatory factors controlling uterine activity during pregnancy remain unclear in many species. Since myometrial relaxants raise intracellular cyclic AMP, modulation of signalling pathways coupling cell-surface receptors to adenylate cyclase activation could be an important site for control. To assess the functional activity of the stimulatory GTP-binding protein Gs we have measured adenylate cyclase activation by GTP, its non-hydrolysable analogue guanosine 5′-(β-γ-imido)triphosphate (Gpp(NH)p), fluoride, forskolin and manganese in a 50 000 g membrane fraction prepared from the

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31

Calhoun, Byron C. "Pulmonary Hypertension: Clinical Parameters of a Difficult Case in Pregnancy." Linacre Quarterly 84, no. 3 (2017): 243–47. http://dx.doi.org/10.1080/00243639.2016.1173812.

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Treatment of pulmonary hypertension in pregnancy with a prostacyclin analogue-iloprost and/or calcium channel antagonists appears to improve outcomes and survival. These medications could have been administered to the patient and the response monitored. If the patient did not respond to therapy, this patient may have had either a referral to or transfer to another high risk center with more experience in this type of pregnant patient. There is no literature to support termination of pregnancy improving maternal survival outcomes in these patients, even though termination is recommended by all

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32

Pinto, T. L. C., J. N. S. Sales, R. R. Carvalho, T. M. França, and J. C. Souza. "160 CONCEPTION RATES FOLLOWING TREATMENT OF LACTATING HOLSTEIN RECIPIENTS WITH A GONADOTROPIN RELEASING HORMONE (GnRH) ANALOGUE AT THE TIME OF TRANSFER OF OVUM PICK-UP/IVF-DERIVED EMBRYOS." Reproduction, Fertility and Development 25, no. 1 (2013): 228. http://dx.doi.org/10.1071/rdv25n1ab160.

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The use of lactating dairy cows as ovum pick-up (OPU)/IVF-derived embryo recipients in large-scale embryo transfer programs may be limited by the effects of low progesterone concentrations on the uterine environment and subsequent embryo development. It was hypothesized that the injection of a GnRH analogue on the day of embryo transfer would induce ovulation and formation of an accessory corpus luteum, increasing progesterone concentrations and, as a result, conception rates. An experiment was designed to evaluate the effects of two different GnRH analogues injected IM on the day of embryo tr

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33

Wu, H.-M., H.-Y. Huang, Y.-K. Soong, P. C. K. Leung, and H.-S. Wang. "Kisspeptin regulation of human decidual stromal cells motility via FAK–Src intracellular tyrosine kinases." Human Reproduction 34, no. 7 (2019): 1291–301. http://dx.doi.org/10.1093/humrep/dez061.

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Abstract STUDY QUESTION Can of Clinical Genetics, Maastricht University Medical Centre, Maastricht kisspeptin and its analogues regulate the motility of human decidual stromal cells and what intracellular signaling pathways are involved? SUMMARY ANSWER Kisspeptin analogue–mediated cell motility in human decidual stromal cells via the focal adhesion kinase (FAK)–steroid receptor coactivator (Src) pathway suggesting that kisspeptin may modulate embryo implantation and decidual programming in human pregnancy. WHAT IS KNOWN ALREADY The extravillous trophoblast invades the maternal decidua during e

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34

Vaganova, Yanina A., Galina A. Suslova, Sergei N. Gaiducov, and Anna Ya Bobko. "The effectiveness of applying medical rehabilitation methods during pregnancy in order to relieve back pain caused by dorsopathy." Pediatrician (St. Petersburg) 9, no. 2 (2018): 30–35. http://dx.doi.org/10.17816/ped9230-35.

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The study is held in order to estimate the efficiency of applying the methods of manual therapy on pregnant women during the second and third trimesters of their pregnancy to relieve pain caused by dorsopathy. During the period from October 2015 until March 2017 was defined a “study” group (n = 25) and the “control” group (n = 25) of pregnant women with the diagnosis of “dorsopathy” (mostly osteochondrosis 66%, scoliosis 18%, intervertebral hernia 16%). The age of pregnant women is ranged from 22 up to 39 years with the gestational term from 18 to 38 weeks. During the study the following metho

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35

Upson, Anthony H. "Vitamin A analogues in pregnancy." Medical Journal of Australia 149, no. 5 (1988): 284. http://dx.doi.org/10.5694/j.1326-5377.1988.tb120615.x.

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36

Szczęch, Justyna, Artur Wiatrowski, Lidia Hirnle, and Adam Reich. "Prevalence and Relevance of Pruritus in Pregnancy." BioMed Research International 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/4238139.

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Pregnant women are at greater risk to suffer from chronic pruritus, but data on this symptom in this group is very limited. The aim of this study was to investigate the prevalence, clinical characteristics, and the importance of pruritus in pregnant women. A total of 292 consecutive pregnant women at the 33.0±6.1 weeks of gestation (WoG) were recruited into this prospective, cross-sectional study. All patients underwent thorough anamnesis and detailed physical examination with the special emphasis on pruritus. Pruritus was assessed according to Visual Analogue Scale (VAS). Quality of life was

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Ata, Baris, Martina Capuzzo, Engin Turkgeldi, Sule Yildiz, and Antonio La Marca. "Progestins for pituitary suppression during ovarian stimulation for ART: a comprehensive and systematic review including meta-analyses." Human Reproduction Update 27, no. 1 (2020): 48–66. http://dx.doi.org/10.1093/humupd/dmaa040.

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Abstract BACKGROUND Progestins are capable of suppressing endogenous LH secretion from the pituitary. Progestins can be used orally and are less expensive than GnRH analogues. However, early endometrial exposure to progestin precludes a fresh embryo transfer (ET), but the advent of vitrification and increasing number of oocyte cryopreservation cycles allow more opportunities for using progestins for pituitary suppression. OBJECTIVE AND RATIONALE This review summarizes: the mechanism of pituitary suppression by progestins; the effectiveness of progestins when compared with GnRH analogues and wi

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Mathiesen, Elisabeth R. "Insulin Aspart in Diabetic Pregnancy: State of the Art." Women's Health 4, no. 2 (2008): 119–24. http://dx.doi.org/10.2217/17455057.4.2.119.

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Pregnancy in women with diabetes is associated with an increased risk of obstetric complications and perinatal mortality. Maintenance of near-normal glycemia during pregnancy can bring the prevalence of fetal, neonatal and maternal complications closer to that of the nondiabetic population. Changes in insulin requirements during pregnancy necessitate short-acting insulins for postprandial control of hyperglycemia. The fast-acting insulin analogue insulin aspart has been tested in a large, randomized trial of pregnant women with Type 1 diabetes and offers benefits in control of postprandial hyp

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Aurich, J. E., I. Dobrinski та N. Parvizi. "β-Endorphin in sows during late pregnancy: effects of cloprostenol and oxytocin on plasma concentrations of β-endorphin in the jugular and uterine veins". Journal of Endocrinology 136, № 2 (1993): 199–206. http://dx.doi.org/10.1677/joe.0.1360199.

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ABSTRACT β-Endorphin was measured in the plasma of pigs during late pregnancy and at different stages of the oestrous cycle. In pregnant animals, β-endorphin secretion from uteroplacental tissues into the maternal circulation and the possible effects of oxytocin and the prostaglandin F2α (PGF2α) analogue cloprostenol on β-endorphin release were determined. Plasma β-endorphin concentrations in pregnant sows were significantly higher than in non-pregnant pigs. However, there were no significant changes in β-endorphin values throughout the oestrous cycle. Because the increase in plasma β-endorphi

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Yevtushenko, I. D., A. Sh Makhmutkhodzhayev, T. V. Ivanova, et al. "Use of prostaglandin synthetic analogue E₁ for uterus cervix preparation and labor induction." Bulletin of Siberian Medicine 2, no. 3 (2003): 75–80. http://dx.doi.org/10.20538/1682-0363-2003-3-75-80.

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A clinical prospective examination of 90 women with complete pregnancy and indications for labor induction because of unsatisfactory maturity of uterus cervix has been made. The aim was to create a comparative analysis of efficiency of intravaginal introduction of prostaglandin synthetic analogue E1 misoprostol («Sytotec») and intracervical introduction of prostaglandin E2 dinoprostone («Prepidil» gel) for uterus cervix preparation and labor induction at complete pregnancy. Misoprostol in a dose of 25 mkg has been introduced to pregnant women of the 1 group (n=44), every 4 hours not more than

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Abad, Antonio, Consuelo Agullo, Manuel Arno, Luis R. Domingo, José Rozalen, and Ramon J. Zaragoza. "Transformation of resin abietic acid into a pregnane-type steroid." Canadian Journal of Chemistry 69, no. 3 (1991): 379–82. http://dx.doi.org/10.1139/v91-058.

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Abietic acid (1a) has been converted into the pregnane analogue steroid 10 via a sequence of transformations involving as key step the acetylene-cation cyclization of 9. Key words: abietic acid, pregnane steroids, acetylene-cation cyclization

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Jung, Sunyoung, Youngjin Park, YoungHoon Kim, et al. "LAPS-FSH: a new and effective long-acting follicle-stimulating hormone analogue for the treatment of infertility." Reproduction, Fertility and Development 26, no. 8 (2014): 1142. http://dx.doi.org/10.1071/rd13118.

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Although several long-acting follicle-stimulating hormone (FSH) therapies have been developed to enhance the ovarian response, a disadvantage of FSH therapy is its relatively short half-life, which requires women to receive one to two injections per day for almost 2 weeks. In the present study, we developed a novel FSH analogue by conjugating recombinant human FSH (rhFSH) and the constant region of the human immunoglobulin G4 fragment via non-peptidyl linkers. The efficacy of the FSH analogue was evaluated in vitro by cAMP level assessments, pharmacokinetic studies and a determination of ovari

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Damiati, Samar. "Serum Levels of Asymmetric and Symmetric Dimethylarginine in Women with Vitamin D Deficiency and History of Pregnancy Loss – A Pilot Study." Journal of Medical Biochemistry 37, no. 4 (2018): 441–47. http://dx.doi.org/10.1515/jomb-2017-0069.

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Summary Background: Vitamin D deficiency has been reported to be associated with pregnancy loss. Asymmetric dimethyl-L-arginine (ADMA) and symmetric dimethyl-L-arginine (SDMA) are arginine analogues that have direct and indirect effects on nitric oxide (NO) synthesis and endothelial dysfunction. This study aimed to evaluate ADMA and SDMA levels among women with history of pregnancy loss compared to women without history of pregnancy loss and all participants were suffering from vitamin D deficiency. Methods: To investigate the relationship between vitamin D deficiency and ADMA and SDMA, both g

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Brown, G. P., and R. C. Venuto. "Angiotensin II receptors in rabbit renal preglomerular vessels." American Journal of Physiology-Endocrinology and Metabolism 255, no. 1 (1988): E16—E22. http://dx.doi.org/10.1152/ajpendo.1988.255.1.e16.

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Controversy exists regarding the specific sites within the renal microcirculation affected by angiotensin II (ANG II). Under some conditions, ANG II can elicit direct vasoconstrictor responses in the preglomerular vessels and efferent arterioles. These experiments were designed to evaluate the binding of 125I-ANG II in preglomerular vessels. Arcuate and interlobular arteries, with attached proximal segments of afferent arterioles, were microdissected from rabbit renal cortexes. A membrane preparation was obtained from the pooled freshly dissected vessels and utilized in an ANG II radioreceptor

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Lambert, K., and R. I. G. Holt. "The use of insulin analogues in pregnancy." Diabetes, Obesity and Metabolism 15, no. 10 (2013): 888–900. http://dx.doi.org/10.1111/dom.12098.

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Lindheimer, Marshall D., and John M. Davison. "Osmoregulation, the secretion of arginine vasopressin and its metabolism during pregnancy." European Journal of Endocrinology 132, no. 2 (1995): 133–43. http://dx.doi.org/10.1530/eje.0.1320133.

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Lindheimer MD, Davison JM. Osmoregulation, the secretion of arginine vasopressin and its metabolism during pregnancy. Eur J Endocrinol 1995;132:133–43. ISSN 0804–4643 This review stresses changes in osmoregulation as well as the secretion and metabolism of aŕginine vasopressin during pregnancy, focusing on human gestation. Pregnant women experience a decrease in body tonicity, plasma osmolality decreasing immediately after conception to a nadir ~ 10 mosmol/kg below non-pregnant levels early in pregnancy, after which a new steady state is maintained until term. Data from both human and rodent g

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Yildirim, Gulay, and Nevin Hotun Sahin. "The Effect of Breathing and Skin Stimulation Techniques on Labour Pain Perception of Turkish Women." Pain Research and Management 9, no. 4 (2004): 183–87. http://dx.doi.org/10.1155/2004/686913.

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OBJECTIVE:To determine the effect of breathing techniques and nurse-administered massage on the pain perception of pregnant woman during labour.SETTING AND PARTICIPANTS:The present study was conducted among pregnant women (75% primiparous) admitted to the SSK Bakirkoy Women and Children’s Hospital (Istanbul, Turkey) between January 1, and September 1, 2000. The patients were in their 38th to 42nd week of pregnancy, not at high risk and expected to have normal vaginal delivery. They were selected from volunteers by nonrandom sampling.STUDY DESIGN:The present study involved 40 cases, with 20 in

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COULAM, CAROLYN B. "EDITORIAL: Analogies Between Pregnancy and Cancer." American Journal of Reproductive Immunology 25, no. 3 (1991): 95. http://dx.doi.org/10.1111/j.1600-0897.1991.tb01072.x.

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Nelson, Hilde Lindemann. "Dethroning Choice: Analogy, Personhood, and the New Reproductive Technologies." Journal of Law, Medicine & Ethics 23, no. 2 (1995): 129–35. http://dx.doi.org/10.1111/j.1748-720x.1995.tb01342.x.

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There is something about the debate over reproductive technologies of all kinds—from coerced use of Norplant to trait-selection technologies, to issues surrounding in vitro fertilization (IVF), to fetal tissue transplantation—that seems to invite dubious analogies. A Tennessee trial court termed Mary Sue and Junior Davis's frozen embryos “in vitro children” and applied a best-interests standard in awarding “custody” to Mary Sue Davis; the Warnock Committee drew an implicit analogy between human gametes and transplantable organs in its recommendation of a voluntary, nonprofit system for collect

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Maina, Aldo, and Tullia Todros. "A novel approach to hyperemesis gravidarum: evaluation by a visual analogue scale score and treatment with transdermal clonidine." Obstetric Medicine 4, no. 4 (2011): 156–59. http://dx.doi.org/10.1258/om.2011.110050.

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Objective A preliminary report on the symptomatic effect of clonidine in severe hyperemesis gravidarum (HG). Design Observational. Settting Hospital based: Ospedale Sant'Anna, Torino, Italy. Population Twelve pregnant women, 8–16 weeks, affected by severe, refractory HG. Methods Assessment by two clinical score indexes: Pregnancy Unique Quantification of Emesis (PUQE) score and a Visual Analogue Scale (VAS) 5-item questionnaire, filled out daily, to detect subjective improvement or worsening of symptoms. Main outcome measures PUQE score and VAS score before and after transdermal clonidine trea

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