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Journal articles on the topic 'Pregnenolone'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Gao, Huaze, Zachary Magin, Nia Fogelman, Rajita Sinha, Gustavo A. Angarita, and Verica Milivojevic. "Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings." Life 14, no. 11 (2024): 1483. http://dx.doi.org/10.3390/life14111483.

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Substance use disorders (SUDs), including cocaine use disorder (CUD), have significant negative health risks and impose a substantial social burden, yet effective treatments are limited. Pregnenolone, a neuroactive steroid precursor, has been shown to reduce alcohol craving and normalize stress biology in individuals with CUD, but its clinical utility has been questioned due to limited data on bioavailability and the stability of blood levels in humans. Thus, this pilot study aimed to determine whether twice-daily oral pregnenolone (PREG) at 300 mg/day and 500 mg/day versus placebo in week two

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2

McKay, S. A., G. Jenkin та G. D. Thorburn. "Peripheral plasma concentrations of pregnenolone sulphate, pregnenolone, progesterone and 20α-hydroxy-4-pregnen-3-one in ewes throughout the oestrous cycle". Journal of Endocrinology 113, № 2 (1987): 231–37. http://dx.doi.org/10.1677/joe.0.1130231.

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ABSTRACT Pregnenolone sulphate, pregnenolone, progesterone and 20α-hydroxy-4-pregnen-3-one concentrations in peripheral plasma of normal cyclic ewes were measured by radioimmunoassay. The concentrations of these steroids were correlated with that of progesterone. The concentrations of all the steroids measured in peripheral plasma varied in a cyclic manner and showed a significant (P <0·05) positive correlation with the concentration of progesterone. Peripheral plasma concentrations of these steroids in ovariectomized and ovariectomized, dexamethasone-treated ewes were also determined. The

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3

Tsang, Benjamin K., David F. Mattice, Ming Li, and Elikplimi K. Asem. "Effect of calcium ionophore A23187 on pregnenolone metabolism to progesterone in rat granulosa cells." Canadian Journal of Physiology and Pharmacology 66, no. 7 (1988): 960–63. http://dx.doi.org/10.1139/y88-157.

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The effect of calcium ionophore A23187 on the metabolism of pregnenolone to progesterone was examined in rat granulosa cells during a 24-h culture period. Granulosa cells harvested from pregnant mare's serum gonadotropin treated immature rats were incubated in the presence and absence of the divalent cation ionophore A23187. The ionophore induced progesterone synthesis from both endogenous sterol substrate and exogenous pregnenolone in a time- and concentration-dependent manner. Pregnenolone metabolism was examined in the presence of aminoglutethimide phosphate, an inhibitor of endogenous preg

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4

Morsy, Mohamed A., Seham A. Abdel-Gaber, Sahar A. Mokhemer, et al. "Pregnenolone Inhibits Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis—Role of Matrix Metalloproteinase 2 and NADPH Oxidase 1." Pharmaceuticals 16, no. 5 (2023): 665. http://dx.doi.org/10.3390/ph16050665.

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The clinical usefulness of doxorubicin (DOX) is limited by its serious adverse effects, such as cardiotoxicity. Pregnenolone demonstrated both anti-inflammatory and antioxidant activity in animal models. The current study aimed to investigate the cardioprotective potential of pregnenolone against DOX-induced cardiotoxicity. After acclimatization, male Wistar rats were randomly grouped into four groups: control (vehicle-treated), pregnenolone (35 mg/kg/d, p.o.), DOX (15 mg/kg, i.p, once), and pregnenolone + DOX. All treatments continued for seven consecutive days except DOX, which was administe

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5

Jiang, Jingjing, Xue Liu, Xiaotian Liu, et al. "The effect of progesterone and pregnenolone on diabetes status in Chinese rural population: a dose–response analysis from Henan Rural Cohort." European Journal of Endocrinology 181, no. 6 (2019): 603–14. http://dx.doi.org/10.1530/eje-19-0352.

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Objective Previous studies have uncovered a progestin-only contraceptive association with an increased risk of diabetes, but limited studies have explored the relationship of endogenous progesterone and pregnenolone levels with diabetes status. A case–control study was conducted in Henan Rural Cohort (register number: ChiCTR-OOC-15006699) to evaluate the dose–response independent and interactive relationship of progesterone and pregnenolone levels with prediabetes and type 2 diabetes mellitus (T2DM) in Chinese rural population. Design A case-control study. Methods A total of 798 T2DM patients,

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6

Legacki, Erin L., Barry A. Ball, C. Jo Corbin, et al. "Equine fetal adrenal, gonadal and placental steroidogenesis." Reproduction 154, no. 4 (2017): 445–54. http://dx.doi.org/10.1530/rep-17-0239.

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Equine fetuses have substantial circulating pregnenolone concentrations and thus have been postulated to provide significant substrate for placental 5α-reduced pregnane production, but the fetal site of pregnenolone synthesis remains unclear. The current studies investigated steroid concentrations in blood, adrenal glands, gonads and placenta from fetuses (4, 6, 9 and 10 months of gestational age (GA)), as well as tissue steroidogenic enzyme transcript levels. Pregnenolone and dehydroepiandrosterone (DHEA) were the most abundant steroids in fetal blood, pregnenolone was consistently higher but

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7

Costa, Barbara, Stefano Pini, Pamela Gabelloni, et al. "The Spontaneous Ala147Thr Amino Acid Substitution within the Translocator Protein Influences Pregnenolone Production in Lymphomonocytes of Healthy Individuals." Endocrinology 150, no. 12 (2009): 5438–45. http://dx.doi.org/10.1210/en.2009-0752.

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Abstract The de novo production of steroids and neurosteroids begins in mitochondria by the conversion of cholesterol to pregnenolone through cytochrome P450 side-chain cleavage (CYP11A1) enzymatic activity. The C-terminal amino acid domain of the translocator protein (TSPO) has been demonstrated to bind cholesterol, thereby determining its mitochondrial translocation. The goal of the present study was to investigate the effect of the Ala147Thr single-nucleotide polymorphism localized in this TSPO region on pregnenolone production in healthy volunteers. Pregnenolone production was evaluated in

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8

Vallée, Monique, Sergio Vitiello, Luigi Bellocchio, et al. "Pregnenolone Can Protect the Brain from Cannabis Intoxication." Science 343, no. 6166 (2014): 94–98. http://dx.doi.org/10.1126/science.1243985.

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Pregnenolone is considered the inactive precursor of all steroid hormones, and its potential functional effects have been largely uninvestigated. The administration of the main active principle of Cannabis sativa (marijuana), ∆9-tetrahydrocannabinol (THC), substantially increases the synthesis of pregnenolone in the brain via activation of the type-1 cannabinoid (CB1) receptor. Pregnenolone then, acting as a signaling-specific inhibitor of the CB1 receptor, reduces several effects of THC. This negative feedback mediated by pregnenolone reveals a previously unknown paracrine/autocrine loop prot

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9

French, Joseph T., and Thomas H. Welsh. "In vitro modulation of porcine Leydig cell steroidogenesis by phorbol-12-myristate-13-acetate and 1,2-dioctanoylglycerol." Acta Endocrinologica 122, no. 1 (1990): 101–6. http://dx.doi.org/10.1530/acta.0.1220101.

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Abstract Serum-free primary cultures of neonatal (1-day-old) porcine Leydig cells were used to study the effects of phorbol-12-myristate-13-acetate and 1,2-dioctanoylglycerol on testosterone and pregnenolone production. Phorbol-12-myristate-13-acetate alone from 0.001-10 μmol/l stimulated testosterone and pregnenolone production, whereas 1,2-dioctanoylglycerol alone had no effect on steroid production, relative to control. Phorbol12-myristate-13-acetate and 1,2-dioctanoylglycerol each inhibited pLH-stimulated testosterone and pregnenolone production. To further clarify the influence of these p

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10

Bracci, Massimo, Laura Zingaretti, Margherita Martelli, et al. "Alterations in Pregnenolone and Testosterone Levels in Male Shift Workers." International Journal of Environmental Research and Public Health 20, no. 4 (2023): 3195. http://dx.doi.org/10.3390/ijerph20043195.

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Steroid hormone levels are closely related to the endogenous circadian rhythm induced by sleep–wake and dark–light cycles. Shift work that disrupts the circadian rhythm may influence the levels of steroid hormones. The association between shift work and alterations in female sex steroid hormone levels has been studied, but little is known about testosterone and its precursor pregnenolone levels in male shift workers. The present study investigated serum pregnenolone and testosterone levels in a group of shift and daytime male workers. All participants were sampled at the beginning of the morni

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11

Mayer, Sabine I., Isabelle Müller, Stefanie Mannebach, Takeshi Endo, and Gerald Thiel. "Signal Transduction of Pregnenolone Sulfate in Insulinoma Cells." Journal of Biological Chemistry 286, no. 12 (2011): 10084–96. http://dx.doi.org/10.1074/jbc.m110.202697.

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The neurosteroid pregnenolone sulfate acts on the nervous system by modifying neurotransmission and receptor functions, thus influencing synaptic strength, neuronal survival, and neurogenesis. Here we show that pregnenolone sulfate induces a signaling cascade in insulinoma cells leading to enhanced expression of the zinc finger transcription factor Egr-1 and Egr-1-responsive target genes. Pharmacological and genetic experiments revealed that influx of Ca2+ ions via transient receptor potential M3 and voltage-gated Ca2+ channels, elevation of the cytosolic Ca2+ level, and activation of ERK are

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12

Tian, Yuan, Yang Hong, Samuel J. Bonacorsi, Aaron Balog та Sharon Gong. "Synthesis of [3α-3H] 17α-Hydroxy pregnenolone and [3α-3H] Pregnenolone". Journal of Labelled Compounds and Radiopharmaceuticals 57, № 1 (2013): 1–11. http://dx.doi.org/10.1002/jlcr.3114.

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13

Lambert, F., J. Lammerant, and J. Kolanowski. "The mechanism of the prolonged stimulatory effect of corticotrophin on pregnenolone production by guinea-pig adrenocortical mitochondria." Journal of Endocrinology 108, no. 3 (1986): 377–84. http://dx.doi.org/10.1677/joe.0.1080377.

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ABSTRACT The postulated prolonged stimulatory influence of ACTH on the adrenocortical mitochondrial synthesis of pregnenolone in response to ACTH was studied in adrenal mitochondria isolated from control guinea-pigs and from animals treated s.c. with 100 μg ACTH(1–24) twice daily on the day before the animals were killed. The animals from both groups were injected with 100 μg ACTH s.c. 30 min before killing. The mitochondrial production of pregnenolone (expressed in nmol per mg mitochondrial protein after 10-min incubation) increased from 1·52 ± 0·46 (s.e.m.) in the control group to 4·50 ± 0·5

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14

Badran, Serene Adnan, Atia-tul-Wahab, Sharmeen Fayyaz, Bushra Taj Muhammad, and Muhammad Iqbal Choudhary. "Effect of Steroidal Hormone Pregnenolone on Proliferation and Differentiation of MC3T3-E1 Osteoblast like Cells." Letters in Drug Design & Discovery 17, no. 9 (2020): 1139–45. http://dx.doi.org/10.2174/1570180817666200204110859.

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Background: Bone remodeling is a complex process that includes continuous resorption by osteoclast cells and bone formation by osteoblast cells. Bone fragility is a common health issue of the elderly population, particularly in postmenopausal women. It has been established that steroidal hormones have an important role in bone homeostasis. Therefore hormone replacement therapy could have beneficial effects on bone health as compared to other treatments. Objectives: An imbalance between the rate of bone formation and bone resorption leads to the fragility of bones. During the current study, we

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15

Stone, BA, RF Seamark, RW Kelly, and S. Deam. "Production of Steroids and Release of Prostaglandins by Spherical Pig Blastocysts in vitro." Australian Journal of Biological Sciences 39, no. 3 (1986): 283. http://dx.doi.org/10.1071/bi9860283.

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Levels of pregnenolone and progesterone in spherical pig blastocysts (near 4 and 15 /lM respectively) exceeded respective levels in histotroph by about 400-fold. When blastocysts were cultured for 5 days in a synthetic medium containing pregnenolone sulfate (l /lM), daily rates of release of pregnenolone, progesterone, androstenedione, testosterone, oestrone and oestradiol were determined to be near 320, 45, 2.6, 27, O' 8 and 9� 2 fmol per blastocyst respectively. Daily outputs of progesterone and testosterone (fmol per blastocyst) diminished (P < O' 05) to l' 3 and undetectable levels � 2)

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16

Lone, Imtiyaz H., and M. Amin Bhat. "Synthesis, Molecular Properties and MIC Studies of D-Ring Chalcone Derivatives of 20-Keto Pregnenolone." Materials Science Forum 760 (July 2013): 15–22. http://dx.doi.org/10.4028/www.scientific.net/msf.760.15.

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An efficient and simple synthesis of 17-chalconyl derivatives of pregnenolone and their antibacterial and antifungal evaluation is reported. The scheme involves the transformation of the starting pregnenolone to the corresponding Chalcone derivatives by the well-known Claisen-Schmidt reaction. Determination of Minimum inhibitory concentrations (MICs) is reported on these newly synthesized Chalcone derivatives of pregnenolone. The prediction of molecular properties is also discussed. Compounds showing lower MIC values also followedLipinski’s rule of 5. The results showed that the activity of th

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17

Naylor, Jennifer C., Christine M. Hulette, David C. Steffens, et al. "Cerebrospinal Fluid Dehydroepiandrosterone Levels Are Correlated with Brain Dehydroepiandrosterone Levels, Elevated in Alzheimer’s Disease, and Related to Neuropathological Disease Stage." Journal of Clinical Endocrinology & Metabolism 93, no. 8 (2008): 3173–78. http://dx.doi.org/10.1210/jc.2007-1229.

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Abstract Objective: It is currently unknown whether cerebrospinal fluid (CSF) neurosteroid levels are related to brain neurosteroid levels in humans. CSF and brain dehydroepiandrosterone (DHEA) levels are elevated in patients with Alzheimer’s disease (AD), but it is unclear whether CSF DHEA levels are correlated with brain DHEA levels within the same subject cohort. We therefore determined DHEA and pregnenolone levels in AD patients (n = 25) and cognitively intact control subjects (n = 16) in both CSF and temporal cortex. Design: DHEA and pregnenolone levels were determined by gas chromatograp

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18

Netchitailo, P., A. Larcher, F. Leboulenger, M. Feuilloley, D. Philibert, and H. Vaudry. "Self-inhibition of steroid secretion by amphibian adrenocortical cells is not mediated through glucocorticoid receptors." Journal of Molecular Endocrinology 6, no. 3 (1991): 249–55. http://dx.doi.org/10.1677/jme.0.0060249.

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ABSTRACT To investigate a possible direct action of glucocorticoids on adrenal steroidogenesis, the effect of corticosterone on the conversion of pregnenolone into various metabolites by frog adrenal tissue was examined. Frog interrenal slices were incubated with [3H]pregnenolone (1 mCi/ml) and the various labelled metabolites analysed by reverse-phase high-performance liquid chromatography. With the methanol gradient used, five identified steroids were resolved: progesterone, 11-deoxycorticosterone, corticosterone, 18-hydroxycorticosterone and aldosterone. Corticosterone (10 μg/ml) induced a

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19

Shumyantseva, V. V., T. V. Bulko, A. Yu Misharin, and A. I. Archakov. "Screening of potential substrates or inhibitors of cytochrome P450 17a1 (CYP17a1) by electrochemical methods." Biomeditsinskaya Khimiya 57, no. 4 (2011): 402–9. http://dx.doi.org/10.18097/pbmc20115704402.

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The electrochemical reduction of the recombinant form of human cytochrome P450 17A1 (CYP17A1) was investigated. Hemeprotein was immobilized on electrode modified with biocompatable nanocomposite material based on the membrane-like synthetic surfactant didodecyldimethylammonium bromide (DDAB) and gold nanoparticles. Analytical characteristics of DDAB/Au/CYP17A1 electrodes were investigated with cyclic voltammetry, square wave voltammetry, and differential pulse voltammetry. Analysis of electrochemical behaviour of cytochrome P450 17A1 was conducted in the presence of substrate pregnenolone (1),

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20

سعود وسمي, أثير. "لتحول الحيوي للبريجنينولون من خلال عمل البنسليوم أولسوني". مجلة العلوم الأساسـية 16, № 24 (2025): 691–709. https://doi.org/10.31185/bsj.vol16.iss24.810.

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يبحث هذا العمل في استخدام فطر Penicillium olsonii في التحول الحيوي لـ pregnenolone. من أجل البحث في إنشاء مشتقات ستيرويد جديدة، تم وضع pregnenolone - وهو مقدمة حاسمة في التخليق الحيوي للهرمونات الستيرويدية - من خلال التحول الميكروبي في بيئة خاضعة للرقابة. تم استخدام كروماتوغرافيا الطبقة الرقيقة (TLC) ومطياف الكتلة (MS) لاستخراج وتحليل المستقلبات بعد حضانة Penicillium olsonii مع pregnenolone لفترات زمنية مختلفة. تم العثور على ثلاثة مستقلبات رئيسية ذات فترات احتفاظ مميزة في النتائج، مما يشير إلى أن الفطر نجح في تغيير البنية. قد يكون Penicillium olsonii قادرًا على إنتاج مواد كيميائية ستيرويدية جد

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21

Deb, Subrata, Steven Pham, Dong-Sheng Ming, et al. "Characterization of Precursor-Dependent Steroidogenesis in Human Prostate Cancer Models." Cancers 10, no. 10 (2018): 343. http://dx.doi.org/10.3390/cancers10100343.

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Castration-resistant prostate tumors acquire the independent capacity to generate androgens by upregulating steroidogenic enzymes or using steroid precursors produced by the adrenal glands for continued growth and sustainability. The formation of steroids was measured by liquid chromatography-mass spectrometry in LNCaP and 22Rv1 prostate cancer cells, and in human prostate tissues, following incubation with steroid precursors (22-OH-cholesterol, pregnenolone, 17-OH-pregnenolone, progesterone, 17-OH-progesterone). Pregnenolone, progesterone, 17-OH-pregnenolone, and 17-OH-progesterone increased

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22

Havlíková, Helena, Martin Hill, Richard Hampl, and Luboš Stárka. "Sex- and Age-Related Changes in Epitestosterone in Relation to Pregnenolone Sulfate and Testosterone in Normal Subjects." Journal of Clinical Endocrinology & Metabolism 87, no. 5 (2002): 2225–31. http://dx.doi.org/10.1210/jcem.87.5.8499.

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Epitestosterone has been demonstrated to act at various levels as a weak antiandrogen. So far, its serum levels have been followed up only in males. Epitestosterone and its major circulating precursor pregnenolone sulfate and T were measured in serum from 211 healthy women and 386 men to find out whether serum concentrations of epitestosterone are sufficient to exert its antiandrogenic actions. In women, epitestosterone exhibited a maximum around 20 yr of age, followed by a continuous decline up to menopause and by a further increase in the postmenopause. In men, maximum epitestosterone levels

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23

Panada, J. U., Y. V. Faletrov, N. S. Frolova, and V. M. Shkumatov. "Synthesis and evaluation of N-alkynylaminosteroids as potential CYP450 17A1 inhibitors." Biomeditsinskaya Khimiya 65, no. 4 (2019): 324–30. http://dx.doi.org/10.18097/pbmc20196504324.

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Four isomeric dehydroepiandrosterone- and pregnenolone-based N-alkynylaminosteroids were synthesized and tested in vitro for inhibition of heterologously expressed CYP17A1. The highest inhibitory activity was observed when the optimal number of side chain atoms was met. The conjugate based on pregnenolone containing an N-propynyl moiety was found to interefere with enzymatic activity most effectively and consistently in the micromolar range.

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Mannowetz, Nadja, Melissa R. Miller, and Polina V. Lishko. "Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids." Proceedings of the National Academy of Sciences 114, no. 22 (2017): 5743–48. http://dx.doi.org/10.1073/pnas.1700367114.

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The calcium channel of sperm (CatSper) is essential for sperm hyperactivated motility and fertility. The steroid hormone progesterone activates CatSper of human sperm via binding to the serine hydrolase ABHD2. However, steroid specificity of ABHD2 has not been evaluated. Here, we explored whether steroid hormones to which human spermatozoa are exposed in the male and female genital tract influence CatSper activation via modulation of ABHD2. The results show that testosterone, estrogen, and hydrocortisone did not alter basal CatSper currents, whereas the neurosteroid pregnenolone sulfate exerte

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Yildirim, Kudret, Ahmet Uzuner, and Emine Yasemin Gulcuoglu. "Biotransformation of some steroids by Aspergillus terreus MRC 200365." Collection of Czechoslovak Chemical Communications 75, no. 6 (2010): 665–73. http://dx.doi.org/10.1135/cccc2009545.

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The biotransformations of testosterone, epiandrosterone, progesterone and pregnenolone byAspergillus terreusMRC 200365 for five days were described. The biotransformation of testosterone afforded testolactone. The biotransformation of epiandrosterone afforded 3β-hydroxy-17a-oxa-D-homo-5α-androstan-17-one. The biotransformation of progesterone afforded androst-4-ene-3,17-dione and testolactone. The biotransformation of pregnenolone afforded 3β-hydroxy-17a-oxa-D-homoandrost-5-en-17-one and testolactone.

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26

Welberg, Leonie. "Pregnenolone limits effects of cannabis." Nature Reviews Neuroscience 15, no. 2 (2014): 66–67. http://dx.doi.org/10.1038/nrn3681.

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Cheney, D. L., D. Uzunov, and A. Guidotti. "Pregnenolone sulfate antagonizes dizocilpine amnesia." NeuroReport 6, no. 12 (1995): 1697–700. http://dx.doi.org/10.1097/00001756-199508000-00025.

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Choudhary, Muhammad Iqbal, Iffat Batool, Syed Adnan Ali Shah, Sarfraz Ahmad Nawaz, and Atta-ur-Rahman. "Microbial Hydroxylation of Pregnenolone Derivatives." CHEMICAL & PHARMACEUTICAL BULLETIN 53, no. 11 (2005): 1455–59. http://dx.doi.org/10.1248/cpb.53.1455.

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Caballero, Gerardo M., and Eduardo G. Gros. "Synthesis of [20,21-13C2]-pregnenolone." Journal of Labelled Compounds and Radiopharmaceuticals 33, no. 10 (1993): 907–11. http://dx.doi.org/10.1002/jlcr.2580331004.

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Prasad, V. V. Kris, and Steven O. Franklin. "Synthesis of (21-3H3)-pregnenolone." Journal of Labelled Compounds and Radiopharmaceuticals 22, no. 4 (1985): 353–58. http://dx.doi.org/10.1002/jlcr.2580220407.

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Wang, Ming-De, Göran Wahlström, and Torbjörn Bäckström. "The regional brain distribution of the neurosteroids pregnenolone and pregnenolone sulfate following intravenous infusion." Journal of Steroid Biochemistry and Molecular Biology 62, no. 4 (1997): 299–306. http://dx.doi.org/10.1016/s0960-0760(97)00041-1.

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32

Melchior, C. L., and R. F. Ritzmann. "Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze." Pharmacology Biochemistry and Behavior 48, no. 4 (1994): 893–97. http://dx.doi.org/10.1016/0091-3057(94)90197-x.

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Yu, Frank H., Young W. Yun, Basil Ho Yuen, and Young S. Moon. "Effects of hydroxyflutamide on rats treated with a superovulatory dose of pregnant mare serum gonadotropin." Canadian Journal of Physiology and Pharmacology 69, no. 2 (1991): 185–90. http://dx.doi.org/10.1139/y91-027.

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Immature female rats treated with superovulatory doses of pregnant mare serum gonadotropin (PMSG) were used to study the effects of the antiandrogen hydroxyflutamide on steroid production, particularly the biologically active androgens, in two experiments. In the first experiment, animals were given either 5 mg hydroxyflutamide or vehicle alone at 30 and 36 h following 40 IU PMSG. Compared with the vehicle group, hydroxyflutamide treatment significantly reduced the percentage of degenerate oocytes recovered from oviducts (p < 0.05). Serum levels of testosterone and androstenedione, and thei

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Banday, Abid H., Shameem A. Shameem, Javid A. Banday та Bashir A. Ganaie. "Synthesis, 17α-hydroxylase-C17,20-lyase Inhibitory and 5AR Reductase Activity of Novel Pregnenolone Derivatives". Anti-Cancer Agents in Medicinal Chemistry 18, № 13 (2019): 1919–26. http://dx.doi.org/10.2174/1871520618666180426100942.

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Background: The potential of steroids for development into lead pharmacological molecules lies in the regulation of a variety of biological processes by these molecules and also because of these being a fundamental class of signaling molecules. Steroid based scaffolds have been extensively used as active pharmaceutical agents for the treatment of various diseases including the deadly disease of cancer which despite the recent advances in the early diagnosis, prevention and therapy, remains a clinical challenge affecting millions of people world over and is one of the leading causes of death. I

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Yildirim, Kudret. "Microbial hydroxylation of some steroids by Aspergillus wentii MRC 200316." Collection of Czechoslovak Chemical Communications 75, no. 12 (2010): 1273–81. http://dx.doi.org/10.1135/cccc2010112.

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Biotransformations of epiandrosterone (1), dehydroepiandrosterone (2) and pregnenolone (3) byAspergillus wentiiMRC 200316 for 5 days have been reported. Incubation of epiandrosterone (1) afforded 11α-hydroxy-5α-androstane-3,17-dione (4) and 3β,11α-dihydroxy-5α-androstan-17-one (5). Incubation of dehydroepiandrosterone (2) afforded 3β,7β-di-hydroxyandrost-5-en-17-one (6) and 3β,7α-dihydroxyandrost-5-en-17-one (7). Incubation of pregnenolone (3) afforded only 11α-hydroxypregn-4-ene-3,20-dione (8).

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Mostovaya, Maria, Svetlana Kalinchenko, and Leonid Vorslov. "PSUN66 Statin Intake as a Cause of Decreased Steroid Hormone Secretion." Journal of the Endocrine Society 6, Supplement_1 (2022): A729. http://dx.doi.org/10.1210/jendso/bvac150.1504.

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Abstract Materials and methods The study enrolled 2 men aged 58 years (history of acute cerebral circulation disorder at 47 and 57 years) and 64 years (history of acute myocardial infarction at 62 years), who complained of shortness of breath, daytime sleepiness, decreased libido, weakened erections, increased blood pressure. Both patients had been taking atorvastatin 10 mg for more than three months. We used high-performance liquid chromatography (HPLC) to determine steroid hormones in saliva: Agilent 1200 chromatograph, AB Sciex 3200 MD mass spectrometer (Sciex, USA). Saliva was collected in

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Witzig, Melissa, Amandine Grimm, Karen Schmitt, et al. "Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis." Cells 9, no. 10 (2020): 2323. http://dx.doi.org/10.3390/cells9102323.

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Neurosteroids are steroids synthetized in the nervous system, with the first step of steroidogenesis taking place within mitochondria with the synthesis of pregnenolone. They exert important brain-specific functions by playing a role in neurotransmission, learning and memory processes, and neuroprotection. Here, we show for the first time that mitochondrial neurosteroidogenesis follows a circadian rhythm and correlates with the rhythmic changes in mitochondrial morphology. We used synchronized human A172 glioma cells, which are steroidogenic cells with a functional core molecular clock, to sho

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Mikami, K., M. Omura, Y. Tamura, and S. Yoshida. "Possible site of action of 5-hydroperoxyeicosatetraenoic acid derived from arachidonic acid in ACTH-stimulated steroidogenesis in rat adrenal glands." Journal of Endocrinology 125, no. 1 (1990): 89–96. http://dx.doi.org/10.1677/joe.0.1250089.

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ABSTRACT The site of action of 5-hydroperoxyeicosatetraenoic acid (5-HPETE) in ACTH-induced stimulation of steroidogenesis was examined in rat adrenocortical fasciculata cells. Prior addition of AA861, a specific inhibitor of 5-lipoxygenase, had no significant effect on cyclic AMP-dependent protein kinase activity and cholesterol esterase activities, when stimulated by ACTH in adrenocortical cells, compared with that stimulated by ACTH alone. Cholesterol accumulation in the mitochondria of cells treated with ACTH and cycloheximide was also not altered by pretreatment with AA861. We found, howe

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Abunnaja, Maryam S., Fatemah A. Alherz, Amal A. El Daibani, et al. "Effects of genetic polymorphisms on the sulfation of dehydroepiandrosterone and pregnenolone by human cytosolic sulfotransferase SULT2A1." Biochemistry and Cell Biology 96, no. 5 (2018): 655–62. http://dx.doi.org/10.1139/bcb-2017-0341.

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The cytosolic sulfotransferase (SULT) SULT2A1 is known to mediate the sulfation of DHEA as well as some other hydroxysteroids such as pregnenolone. The present study was designed to investigate how genetic polymorphisms of the human SULT2A1 gene may affect the sulfation of DHEA and pregnenolone. Online databases were systematically searched to identify human SULT2A1 single nucleotide polymorphisms (SNPs). Of the 98 SULT2A1 non-synonymous coding SNPs identified, seven were selected for further investigation. Site-directed mutagenesis was used to generate cDNAs encoding these seven SULT2A1 alloz

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Cymeryng, CB, LA Dada, and EJ Podesta. "Effect of nitric oxide on rat adrenal zona fasciculata steroidogenesis." Journal of Endocrinology 158, no. 2 (1998): 197–203. http://dx.doi.org/10.1677/joe.0.1580197.

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The present study was designed to investigate the role of nitric oxide (NO) in the regulation of adrenocortical function. Different NO donors, such as sodium nitroprusside (SNP), S-nitroso-L-acetyl penicillamine, diethylamine/NO complex sodium salt and diethylenetriamine NO adduct, significantly decreased corticosterone production both in unstimulated and in corticotropin-stimulated zone fasciculata adrenal cells, in a dose-dependent manner. The effect of SNP was reversed by ferrous hemoglobin. A selective inhibitor of NO synthase, L-NG-nitro-arginine significantly increased corticosterone sec

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Rommerts, F. F. G., J. W. Hoogerbrugge, and H. J. van der Molen. "Stimulation of steroid production in isolated rat Leydig cells by unknown factors in testicular fluid differs from the effects of LH or LH-releasing hormone." Journal of Endocrinology 109, no. 1 (1986): 111–17. http://dx.doi.org/10.1677/joe.0.1090111.

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ABSTRACT After the addition of charcoal-treated testicular fluid to Leydig cells isolated from 22-day-old rats, pregnenolone production could be increased to a maximum of tenfold within 30 min in a dose-dependent manner. Testicular fluid, but not serum, further increased pregnenolone formation threefold when pregnenolone production by Leydig cells was stimulated by the addition of LH-releasing hormone (fourfold), LH (25-fold) and 22R-hydroxycholesterol (300-fold). The effect of testicular fluid on steroid production in the presence of 22R-hydroxycholesterol was not inhibited by cycloheximide w

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Chang, Tom, Marc Levine, and Gail D. Bellward. "Influence of sex and inducer treatment on the high- and low-affinity forms of hepatic microsomal erythromycin N-demethylase in rats." Canadian Journal of Physiology and Pharmacology 68, no. 12 (1990): 1510–13. http://dx.doi.org/10.1139/y90-229.

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To study the regulation of the multiple forms of erythromycin N-demethylase, we determined the influence of sex and inducer treatment on this mixed-function oxidase activity in adult Wistar rats injected intraperitoneally once daily for 4 days with dexamethasone, pregnenolone-16α-carbonitrile, phenobarbital, or 2% Tween 80 (control). Based on the results from a computer curve-fitting procedure (ENZFITTER) as well as Eadie–Hofstee and Lineweaver–Burk plots, at least two forms of erythromycin N-demethylase were present in control, dexamethasone, pregnenolone-16α-carbonitrile, and phenobarbital-t

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Yildirim, Kudret, Ahmet Uzuner, and Emine Yasemin Gulcuoglu. "Baeyer–Villiger oxidation of some steroids by Aspergillus tamarii MRC 72400." Collection of Czechoslovak Chemical Communications 76, no. 6 (2011): 743–54. http://dx.doi.org/10.1135/cccc2011008.

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Biotransformations of epiandrosterone (1), dehydroepiandrosterone (2), testosterone (3), progesterone (4) and pregnenolone (5) byAspergillus tamariiMRC 72400 for 5 days have been reported and the results of these incubations have been compared with previously published data obtained withAspergillus tamariiQM 1223.A. tamariiMRC 72400 showed higher Bayer–Villiger monooxygenase activities thanA. tamariiQM 1223 did. Apart from pregnenolone (5),A. tamariiMRC 72400 metabolized these steroids in different ways. Incubation of epiandrosterone (1) afforded 3β,11β-dihydroxy-5α-androstan-17-one (6) (3%) a

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Hanson, James R., and Kudret Yildirim. "Steroidal Aphidicolin Analogues Derived from Pregnenolone." Journal of Chemical Research 23, no. 12 (1999): 698–99. http://dx.doi.org/10.1177/174751989902301207.

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The conversion of pregnenolone into the 3β,5α-, 3α,5α-, 4β,5α-, 3α,4α-, 3α,4β- and 3α,4α-dihydroxy derivatives of 17β-hydroxymethyl-5β-androstane as steroidal analogues of the diterpenoid DNA polymerase α inhibitor, aphidicolin, is described.

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Bellocchio, Luigi, and Giovanni Marsicano. "Forgetting in obesity: The pregnenolone link." Cell Metabolism 34, no. 2 (2022): 187–88. http://dx.doi.org/10.1016/j.cmet.2022.01.006.

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Hanson, James R., and Kudret Yildirim. "Steroidal Aphidicolin Analogues Derived from Pregnenolone." Journal of Chemical Research, no. 12 (1999): 698–99. http://dx.doi.org/10.1039/a905656d.

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Bernès, Sylvain, Hugo Torrens, Angela López-Giral, and Alfredo Buttenklepper. "Pregnenolone hemisuccinate: aP1 structure withZ′ = 4." Acta Crystallographica Section E Structure Reports Online 59, no. 9 (2003): o1372—o1375. http://dx.doi.org/10.1107/s160053680301835x.

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SAUDAN, C., A. DESMARCHELIER, P. SOTTAS, P. MANGIN, and M. SAUGY. "Urinary marker of oral pregnenolone administration." Steroids 70, no. 3 (2005): 179–83. http://dx.doi.org/10.1016/j.steroids.2004.12.007.

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Iqbal Choudhary, M., M. Shahab Alam, Atta-ur-Rahman, et al. "Pregnenolone derivatives as potential anticancer agents." Steroids 76, no. 14 (2011): 1554–59. http://dx.doi.org/10.1016/j.steroids.2011.09.006.

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Morfin, R., J. Young, C. Corpechot, B. Egestad, J. Sjovall, and E. E. Baulieu. "Neurosteroids: pregnenolone in human sciatic nerves." Proceedings of the National Academy of Sciences 89, no. 15 (1992): 6790–93. http://dx.doi.org/10.1073/pnas.89.15.6790.

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