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Journal articles on the topic 'Premalignant cervical lesions'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Davison, James M., and Jerry J. Marty. "Detecting Premalignant Cervical Lesions." Obstetrical & Gynecological Survey 49, no. 9 (1994): 627. http://dx.doi.org/10.1097/00006254-199409000-00019.

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2

Basu, Partha, Katayoun Taghavi, Shang-Ying Hu, Sushma Mogri, and Smita Joshi. "Management of cervical premalignant lesions." Current Problems in Cancer 42, no. 2 (2018): 129–36. http://dx.doi.org/10.1016/j.currproblcancer.2018.01.010.

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3

Lindeque, B. G. "Management of cervical premalignant lesions." Best Practice & Research Clinical Obstetrics & Gynaecology 19, no. 4 (2005): 545–61. http://dx.doi.org/10.1016/j.bpobgyn.2005.02.008.

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4

International, Journal of Medical Science and Innovative Research (IJMSIR). "Efficacy of Cryotherapy in Treatment of Benign and Premalignant Cervical Lesions." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 6 (2024): 15–21. https://doi.org/10.5281/zenodo.15449406.

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<strong>Abstract</strong> <strong>Introduction:</strong> Benign cervical lesions, such as cervical erosion and chronic cervicitis, frequently present with symptoms like vaginal discharge, pelvic pain, dyspareunia, and abnormal bleeding. These symptoms significantly impact women's quality of life, often leading to ineffective outpatient treatments. Additionally, premalignant cervical lesions pose a risk of progression to cervical cancer, which is a leading cause of cancer-related deaths in India. <strong>Aim & Objective: </strong>This study evaluates the efficacy of cryotherapy in treating

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Kose, Faruk M., and Murat M. Naki. "Cervical premalignant lesions and their management." Journal of the Turkish German Gynecological Association 15, no. 2 (2014): 109–21. http://dx.doi.org/10.5152/jtgga.2014.29795.

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Atla, Bhagyalakshmi, Uma Prasad, Saraswathi Samantra, Venkata Satya Kartheek Botta, Naresh Dasari, and Glen Christopher Changala. "Clinicopathological study of premalignant and malignant lesions of cervix along with apoptotic index and Ki-67 expression." International Journal of Research in Medical Sciences 8, no. 10 (2020): 3543. http://dx.doi.org/10.18203/2320-6012.ijrms20204226.

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Background: Cervical cancer is known to have a good response to radiotherapy. The response and prognosis are dependent on the level of apoptosis. Pap smear and histopathology are cost-effective methods in diagnosing premalignant and malignant lesions of cervix but not accurate in classifying and estimating the progression of the disease, especially in premalignant lesions. Therefore this study was undertaken to know the role of Ki-67 expression and apoptotic index in classifying accurately the premalignant lesions for better management.Methods: The study included 540 cases diagnosed histologic

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Silva-López, Mariana Sarai, César Arturo Ilizaliturri Hernández, Hugo Ricardo Navarro Contreras, Ángel Gabriel Rodríguez Vázquez, Alejandra Ortiz-Dosal, and Eleazar Samuel Kolosovas-Machuca. "Raman Spectroscopy of Individual Cervical Exfoliated Cells in Premalignant and Malignant Lesions." Applied Sciences 12, no. 5 (2022): 2419. http://dx.doi.org/10.3390/app12052419.

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Cervical cancer is frequent neoplasia. Currently, the diagnostic approach includes cervical cytology, colposcopy, and histopathology studies; combining detection techniques increases the sensitivity and specificity of the tests. Raman spectroscopy is a high-resolution technique that supports the diagnosis of malignancies. This study aimed to evaluate the Raman spectroscopy technique discriminating between healthy and premalignant/malignant cervical cells. We included 81 exfoliative cytology samples, 29 in the “healthy group” (negative cytology), and 52 in the “CIN group” (premalignant/malignan

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Akanksha, Thora, Vani Pratibha, Sinha Kirti, Dave Anupama, and Thakur Vibhuti. "Effectiveness of Swede Score in Detection of Cervical Premalignant Lesions." International Journal of Pharmaceutical and Clinical Research 15, no. 12 (2023): 1585–90. https://doi.org/10.5281/zenodo.11205169.

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<strong>Background & Methods: </strong>The aim of the study is to study the Effectiveness of Swede Score in Detection of Cervical Premalignant Lesions. Participants had to be women who were sexually active, at least 30 years old, had abnormal vaginal discharge, had a positive Pap smear/ VIA /VILI, had postcoital or postmenopausal bleeding, and had postcoital or postmenopausal bleeding. Women who were pregnant, women who had a visible growth on the cervix, women who had cervical intraepithelial neoplasia (CIN) or cervical cancer in the past or after treatment, women older than 30 years

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Golubovic, Mileta, Milena Lopicic, Natasa Terzic, Marija Djurovic, Boban Mugosa, and Gordana Mijovic. "Presence of histopathological premalignant lesions and infection caused by high-risk genotypes of human papillomavirus in patients with suspicious cytological and colposcopy results: A prospective study." Vojnosanitetski pregled 74, no. 1 (2017): 24–30. http://dx.doi.org/10.2298/vsp150205143g.

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Background/Aim. In patients with premalignant cervical lesions, human papillomavirus (HPV) infection, at any moment, may be spontaneously eliminated, or may persist or transform cervical epithelium from a lower to a higher degree. Due to that, it is necessary to wisely select the patients who are at high risk of cancer development. The aim of the study was to establish the interdependence between a suspicious Papanicolaou (Pap) test and colposcopy with the infection caused by high-risk genotypes of human papillomavirus and the presence of premalignant cervical lesions. Methods. This prospectiv

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Mustapha, Aisha, Echezona Malachy, Anisah Yahya, Abimbola Kolawole, Adekunle Oguntayo, and Bala M. Audu. "Eliminating Cervical Cancer Using “Screen and Treat”: A Demonstration Project in Kaduna State, Nigeria." International Journal of Medicine and Health Development 30, no. 1 (2025): 45–53. https://doi.org/10.4103/ijmh.ijmh_23_24.

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Abstract Background: In Nigeria, cervical cancer kills one woman every hour. Screening for cervical cancer is still opportunistic. Objectives: This study aimed at performing cervical screening for women in Kaduna State by using “screen and treat” and determining the correlates of premalignant lesions with socio-demography and risk factors and treating women testing positive. Materials and Methods: Using multistage sampling, three hospitals were chosen, community entry was done, and a structured proforma was used to obtain data. Consenting eligible women were screened using visual inspection me

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Shrestha, Buddhi Kumar, Chin Bahadur Pun, Subha Shrestha, Alok Chandra Mahato, and Deeva Shrestha. "Pre-Malignant Lesions of Cervix in Female Attending a Tertiary Hospital of Nepal." Journal of College of Medical Sciences-Nepal 19, no. 2 (2023): 194–200. http://dx.doi.org/10.3126/jcmsn.v19i2.55971.

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Introduction: Cervical cancer is killing Nepali women in gross even though cervical cancer is preventable with time-tested screening strategies in Nepal. Detection of premalignant lesions of cervix is preliminary step for early treatment and to minimise the tragedy of death. The aim of this research is to corelate the Pap smear, colposcopy and guided biopsy findings with histopathology to detect premalignant lesion of cervix.Methods: A prospective observational study conducted among 145 women attending gynaecology OPD with symptoms during reproductive age 21-65 years. Collection of Pap smear w

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Pandey, Abha, Smita Chandra, Ruchira Nautiyal, and Vikas Shrivastav. "Expression of p16INK4a and human papillomavirus 16 with associated risk factors in cervical premalignant and malignant lesions." South Asian Journal of Cancer 07, no. 04 (2018): 236–39. http://dx.doi.org/10.4103/sajc.sajc_118_17.

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Abstract Introduction: Human papilloma virus (HPV) which is causative factor for cervical cancer may interact with p16 leading to malignant transformation of cervical epithelial cells. The present study was conducted to assess the immunoexpression of p16 INK4a in premalignant and malignant lesions of cervix and to correlate it with HPV 16 expression. It was also intended to study the various risk factors which may be associated with cervical cancer in this north Himalayan region of India. Material and Methods: The study included 50 cases of premalignant and malignant cervical lesions and 50 co

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Senthil, Kumar S. "Prevalence of HIV Infections among Women with Cervical Premalignant Lesions in a Tertiary Health Care Centre." International Journal of Pharmaceutical and Clinical Research 16, no. 8 (2024): 1033–39. https://doi.org/10.5281/zenodo.13621094.

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<strong>Introduction</strong>: Premalignant cervical lesions have a high risk of developing into cervical cancer. Cervical cancers among women are very common but greatly preventable using simple cervical screening. Women with HIV infection present with increased incidence of cervical cancers but the results are variable. Thus the present study was done to assess the prevalence of premalignant lesion and their association with HIV infections. <strong>Materials and Methods</strong>: This cross sectional study was done for duration of 1yr from May 2023 to April 2024 in a tertiary care centr

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Pleş, Liana, Julia-Carolina Radosa, Romina-Marina Sima, Radu Chicea, Octavian-Gabriel Olaru, and Mircea-Octavian Poenaru. "The Accuracy of Cytology, Colposcopy and Pathology in Evaluating Precancerous Cervical Lesions." Diagnostics 12, no. 8 (2022): 1947. http://dx.doi.org/10.3390/diagnostics12081947.

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Introduction: Cervical cancer (CC) is the third most common cancer in the world, and Romania has the highest incidence of cervical cancer in Europe. The aim of this study was to evaluate the correlation between cytology, colposcopy, and pathology for the early detection of premalignant cervical lesions in a group of Romanian patients. Methods: This observational type 2 cohort study included 128 women from our unit, “Bucur” Maternity, who were referred for cervical cancer screening. Age, clinical diagnosis, cytology results, colposcopy impression, and biopsy results were considered. Colposcopy

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15

Aishatu, Omoragbon, Emmanuel Gabriel Olusegun, Muftau Shabi Olabode, et al. "Papanicoleau Smear Usage and Prevalence of Premalignant Cervical Lesion among Women Living with HIV Attending a Federal Teaching Hospital in South-West Nigeria: A Comparative Study." Journal of Cancer and Tumor International 5, no. 4 (2017): 1–9. https://doi.org/10.9734/JCTI/2017/33231.

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<strong>Aim:</strong> Cancer of the cervix is the third most common cancer among women worldwide, and in Nigeria it is the second most common female cancer. Infection with the Human immunodeficiency virus (HIV) is associated with an increased risk of prevalent, incident and persistent squamous intraepithelial lesions (SILs) of the cervix. The aim was to determine the level of awareness of cervical cancer screening test and the development of premalignant cervical lesions among HIV positive women. <strong>Study Design:</strong> A Hospital based comparative cross-sectional study. <strong>Place a

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16

Makaju, Ramesh, Binod Dhakal, and Rachana Dhakal. "Clinicopathological correlation of uterine cervical lesions with focus on premalignant and malignant lesions." Journal of Pathology of Nepal 9, no. 2 (2019): 1560–63. http://dx.doi.org/10.3126/jpn.v9i2.26447.

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Background: Cervical cancer ranks as the most frequent cancer among women in Nepal and the first most frequent cancer among women between 15 and 44 years of age. The objectives of the study are to find the incidence of premalignant and malignant cervical conditions and to correlate histopathological diagnosis with that of clinical diagnosis. Materials and Methods: This was a retrospective study carried out at Kathmandu University Hospital. All cervical biopsy done from January 2009 to December 2018, were included in the study. A proforma was created in which relevant demographic data lik

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Kaur, Guneet, Shivani, Vijay Zutshi, and Amit Kumar Yadav. "Role of Multiple Cervical Biopsies on Colposcopy for the Detection of Premalignant and Malignant Lesions of the Cervix." Journal of Colposcopy and Lower Genital Tract Pathology 2, no. 3 (2024): 97–103. https://doi.org/10.4103/jclgtp.jclgtp_16_24.

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Introduction: Cervical cancer screening is done by various methods like pap smear testing, visual inspection with acetic acid (VIA) and visual inspection with lugol’s iodine (VILI), and HPV DNA testing. All screen-positive women are subjected to colposcopy, and colposcopic-directed biopsy is taken from the abnormal area, and sent for histopathology, which is the gold standard for diagnosing premalignant and malignant lesions cervix. Colposcopy has some limitations because it is a subjective test, and its accuracy relies on the physician’s experience and performance to a great extent. To improv

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18

Yarlagadda, Srilakshmi, Rangarao Diddi, and Prasuna J. L. Narra. "Evaluation of women with postcoital bleeding by clinical examination, papsmear, colposcopy and histopathology of cervix." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 6 (2018): 2184. http://dx.doi.org/10.18203/2320-1770.ijrcog20182053.

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Background: Postcoital bleeding refers to spotting or bleeding per vagina that occurs after intercourse and is not related to menstruation. Although there are multiple benign etiologies to this complaint, the most serious cause of postcoital bleeding is cervical cancer (3-5.5%). Cervical cancer is the most common and preventable genital cancer of women. It has a long premalignant phase and with an ideal screening test with good sensitivity and specificity, we can diagnose and treat premalignant cervical lesions, preventing cervical cancer. The present study is aimed to evaluate the women with

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Pitner, Iva, Nives Duric Orsag, Bernarda Škrtić, et al. "Colposcopy Significance in Cervical Premalignant Lesions During Pregnancy." Journal of Gynecologic Surgery 33, no. 5 (2017): 189–92. http://dx.doi.org/10.1089/gyn.2017.0023.

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20

Lambert, Ana Paula Franco, Fernando Anschau, and Virgínia Minghelli Schmitt. "p16INK4A expression in cervical premalignant and malignant lesions." Experimental and Molecular Pathology 80, no. 2 (2006): 192–96. http://dx.doi.org/10.1016/j.yexmp.2005.08.005.

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21

Gursoy, Ali. "Efficacy of Acetic Acid and Lugol's Iodine Assisted Colposcopic Imaging in Cases with Anormal Pap Smear Test Results." Chronicles of Precision Medical Researchers 4, no. 1 (2023): 91–95. https://doi.org/10.5281/zenodo.7709009.

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Aim: This study was conducted to investigate the diagnostic efficacy of colposcopic imaging with Acetic Acid and Lugol’s Iodine in cases with abnormal pap smear test results. Material and Method: Hundred and five patients who presented to the Maltepe University Medical Faculty Hospital Gynecology Outpatient Clinic between 2017 and 2020 with abnormal pap smear results and whose biopsy was taken using colposcopic imaging were evaluated retrospectively. The study included patients with Pap smear results indicating atypical squamous cells of undetermined significance (ASCUS), low grade squam

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22

Lim, F. K. "Management of Premalignant Lesions of the Cervix." Annals of the Academy of Medicine, Singapore 31, no. 3 (2002): 357–65. https://doi.org/10.47102/annals-acadmedsg.v31n3p357.

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The screening, detection and treatment of precancer lesions of the cervix have resulted in a dramatic decline in the incidence of cervical cancer in many parts of the world. The effect is most pronounced in countries with organised screening. The proper management of premalignant lesions of the cervix is an important and integral part of any screening programme. The importance of proper colposcopic technique and the adherence to well-established colposcopic guidelines cannot be overemphasised to ensure appropriate treatment. The colposcope is indispensable in treatment planning as it guides th

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Catalán-Castorena, Oscar, Olga Lilia Garibay-Cerdenares, Berenice Illades-Aguiar, et al. "Bioinformatics Analysis of Human Papillomavirus 16 Integration in Cervical Cancer: Changes in MAGI-1 Expression in Premalignant Lesions and Invasive Carcinoma." Cancers 16, no. 12 (2024): 2225. http://dx.doi.org/10.3390/cancers16122225.

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HPV 16 integration is crucial for the onset and progression of premalignant lesions to invasive squamous cell carcinoma (ISCC) because it promotes the amplification of proto-oncogenes and the silencing of tumor suppressor genes; some of these are proteins with PDZ domains involved in homeostasis and cell polarity. Through a bioinformatics approach based on interaction networks, a group of proteins associated with HPV 16 infection, PDZ domains, and direct physical interaction with E6 and related to different hallmarks of cancer were identified. MAGI-1 was selected to evaluate the expression pro

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Sljivancanin, Dragisa, Vesna Kesic, Lidija Tulic, and Jelena Dotlic. "Assessment of the natural course and treatment of premalignant uterine cervical lesions in pregnancy." Srpski arhiv za celokupno lekarstvo 141, no. 3-4 (2013): 192–97. http://dx.doi.org/10.2298/sarh1304192s.

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Introduction. Premalignant changes of the uterine cervix occur with similar frequency during pregnancy and in non?pregnant women. Due to the fact that any surgery on the cervix can jeopardize pregnancy, it is important to define the protocol of procedures for the treatment of these changes during pregnancy. Objective. The aim of the study was to investigate the natural course of premalignant cervical changes during pregnancy and the impact of their treatment on the pregnancy course. Methods. Study involved all patients with colposcopically, cytologically and hystopathologically diagnosed prema

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Sinchana KM, Meena N. Jadhav, and Shreekant K. Kittur. "Cytomorphological study of cervical Pap smear based on the Bethesda system 2014." Indian Journal of Pathology and Oncology 9, no. 3 (2022): 232–37. http://dx.doi.org/10.18231/j.ijpo.2022.055.

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: The Papanicolaou (Pap) smear used worldwide for cervical screening was developed by Dr George Papanicolaou in 1940s. The Pap smear is a simple, safe and effective test to detect cervical cancer at an early stage.: To study the spectrum of lesions in cervical Pap smear based on The Bethesda System(TBS) 2014 and to determine frequency of premalignant and malignant lesions.: The present prospective study included 200 cases above 20 years of age. The cytological interpretation of smears were made according to TBS 2014. When there was difficulty in differentiating HSIL from other lesions p16 immu

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Hwang, Sonya J., and Kenneth R. Shroyer. "Biomarkers of Cervical Dysplasia and Carcinoma." Journal of Oncology 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/507286.

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Although cervical cytology screening has decreased the incidence of cervical cancer in industrialized countries, HPV-related cervical disease, including premalignant and malignant lesions, continues to represent a major burden on the health care system. Some of the problems include the potential for either under- or overtreatment of women due to decreased specificity of screening tests as well as significant interobserver variability in the diagnosis of cervical dysplastic lesions. Although not completely elucidated, the HPV-driven molecular mechanisms underlying the development of cervical le

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Baidya, Nath Thakur. "Assessment of Histopathological Features of Cervical Lesions: A Retrospective Study." International Journal of Toxicological and Pharmacological Research 13, no. 4 (2023): 155–59. https://doi.org/10.5281/zenodo.11217187.

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<strong>Aim: </strong>To study the histopathological features of cervical lesions. <strong>Materials and Methods:</strong> A retrospective study was done in the Department of Pathology at Shree Narayan Institute of medical sciences, Saharsa, Bihar, India for 12 months. <strong>Results:</strong> 87.7% (307/350) lesions were Non-neoplastic and majority was inflammatory in nature second most common was benign lesions 25 (7.1%). Invasive lesions occupied only 2.8% (8/350) and pre invasive about 2.2% (10/350) respectively. <strong>Conclusion:</strong> Histopathology st

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Akhalesh, Kumar, Rituraj, and Kumar Singh Pradeep. "A Hospital Based Retrospective Histopathological Assessment of the Cervical Lesions." International Journal of Pharmaceutical and Clinical Research 14, no. 3 (2022): 343–48. https://doi.org/10.5281/zenodo.13845339.

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<strong>Aim: </strong>To study the histopathological features of cervical lesions. <strong>Materials and Methods:</strong> A retrospective study was done in the department of Pathology at Government Medical College, Bettiah, Bihar, India, over a period for 1 year. <strong>Results:</strong> 87.7% (307/350) lesions were Non-neoplastic and majority was inflammatory in nature second most common was benign lesions 25 (7.1%). Invasive lesions occupied only 2.8% (8/350) and pre invasive about 2.2% (10/350) respectively. <strong>Conclusion:</strong>Histopathology study of

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Shevra, Chhaya Rani, Himanshu Kumar, Mayank Singh, Sudha Sharma, and Hema Shobhane. "Study of Expression of p16 and Ki-67 in Cervical Squamous Intraepithelial Lesion and Cervical Carcinoma and Its Role as a Predictive Marker in Human Papilloma Virus Infection." CHRISMED Journal of Health and Research 11, no. 4 (2024): 178–83. https://doi.org/10.4103/cjhr.cjhr_114_24.

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Abstract Background: Cervical cancer is the most common cancer in women worldwide, and early diagnosis of cervical malignancies is the key of treatment and an effective screening method. Histopathology and immunohistochemistry are the gold standard for diagnosing cervical lesions. The immunohistochemistry expression of p16 together with the proliferative marker Ki-67 correlates well with the degree of cervical intraepithelial lesions and malignancies. Aims and Objectives: The present study was undertaken to study and compare the expression profile of protein p16 and Ki-67 in cervical intraepit

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Prashanthi, Juturu, Suchitra Ramavath, Manoranjan Reddy Obulareddigari, et al. "A Study on Pap Smear Screening Results Conducted in Teaching Hospital: Analysis of Findings." International Journal of Pharmaceutical and Clinical Research 16, no. 10 (2024): 531–35. https://doi.org/10.5281/zenodo.14037136.

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<strong>Background: </strong>Cervical cancer is one of the major health problems among women in terms of morbidity and mortality. Early identification is beneficial in effective treatment and helps to prevent precancerous lesions from progressing to cancerous conditions. For early detection several screening methods are available. The present study aimed to evaluate PAP smear screening among healthy women in identifying infectious, premalignant, and malignant lesions to determine the prevalence of various lesions. <strong>Methods:</strong> We collected PAP smears from healthy wo

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R. K., Suma, and Keerthi S. Yalaburgi. "Screening of pre cancer and cancer cervix by Pap smear among women in reproductive age group: a community based study." International Journal Of Community Medicine And Public Health 6, no. 1 (2018): 129. http://dx.doi.org/10.18203/2394-6040.ijcmph20185141.

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Background: Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in females worldwide. The disproportionately high burden of cervical cancer in developing countries is largely due to a lack of screening that allows detection of precancerous and early stage cervical cancer. The objective of this study was to identify pre cancer, cancer of cervix by Pap smear test and the factors associated with cervical cancer.Methods: A cross sectional study was done among married women in the reproductive age group of 15-49 years in the urban field practice

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Gupta, Sumedha, Shalu Shalu, Dheer Singh Kalwaniya, and Saritha Shamsunder. "Overview of thermal ablation and LLETZ in cervical premalignant lesions: a narrative review." New Indian Journal of OBGYN 11, no. 1 (2024): 4–10. https://doi.org/10.21276/obgyn.20252024.11.1.02.

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Yang, Ling, Wen-Tao Liu, Hao Wu, Cheng Wang, Bo Ping, and Da-Ren Shi. "Separation of Normal and Premalignant Cervical Epithelial Cells Using Confocal Light Absorption and Scattering Spectroscopic MicroscopyEx Vivo." Journal of Biomedicine and Biotechnology 2011 (2011): 1–5. http://dx.doi.org/10.1155/2011/214781.

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Confocal light absorption and scattering spectroscopic (CLASS) microscopy can detect changes in biochemicals and the morphology of cells. It is therefore used to detect high-grade cervical squamous intraepithelial lesion (HSIL) cells in the diagnosis of premalignant cervical lesions. Forty cervical samples from women with abnormal Pap smear test results were collected, and twenty cases were diagnosed as HSIL; the rest were normal or low-grade cervical squamous intraepithelial lesion (LSIL). The enlarged and condensed nuclei of HSIL cells as viewed under CLASS microscopy were much brighter and

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M Vijayalakshmi, Sharmila Thilagavathy N, and Rani K. "Role of HER2/neu expression in premalignant and malignant lesions of uterine cervix." Indian Journal of Pathology and Oncology 9, no. 3 (2022): 243–47. http://dx.doi.org/10.18231/j.ijpo.2022.057.

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Many research studies on various biomarkers were done, in analysing the prognosis and in evaluation of therapeutic target strategies which improves the survival rate in carcinoma of cervix. Of these, one of the important biomarker is HER-2/neu. To correlate histomorphology of cervical lesions, various clinicopathological parameters with HER-2/neu. The present study conducted during the period from June 2017 to May 2019 in department of Pathology, Madurai Medical College, Madurai. 200 cases were selected for study. Among those, 50 cases were selected for immunohistochemical studies with HER 2.

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Sathiyamurthy, K., S. Waheeda, and N. Sangeetha. "Histopathological study of cervical lesions in a tertiary health care centre in south India." Indian Journal of Pathology and Oncology 8, no. 4 (2021): 447–51. http://dx.doi.org/10.18231/j.ijpo.2021.093.

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Cervix is vulnerable to many pathological changes ranging from inflammation to malignancy. Uterine cervix is gateway to several non-neoplastic and neoplastic gynaecological lesions.. Histopathological studies of cervix along with clinical correlation helps in early diagnosis of lesions as they have advantages of being relatively cheap and technically easy.To study the histopathological features of cervical lesions. A retrospective study was done in the department of Pathology at Vinayaka Mission’s Kirupananda Variyar Medical College and Hospital, Salem for duration of 05 years i.e., from April

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Achawal, Shruti, and Ajit Deshpande. "Colposcopic Findings in Patients of Cervical Erosion at Tertiary Center." Scholars Journal of Applied Medical Sciences 10, no. 2 (2022): 231–34. http://dx.doi.org/10.36347/sjams.2022.v10i02.015.

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Background: India has a population of approximately 450 million women 18 years of age and older who are at a risk of developing cervical cancer. Recent studies state that nearly every year 122844 women are diagnosed with cervical cancer and approximately 67477 die from cervical cancer. Cervical cancer ranks as the 2nd most frequent cancer among women in India. Cervical erosion is one of the commonest clinical finding in women attending Gynecology outpatient department for various reasons. Cervical erosion which is an abnormality of the cervical epithelium covering ectocervix, has a varied sign

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B., Divya, Ashwini U. Nayak, and Sridhar Honappa. "Study of p53 expression in premalignant squamous epithelial lesions of cervix." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 8 (2017): 3297. http://dx.doi.org/10.18203/2320-1770.ijrcog20173129.

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Background: Every year in India, 1,22,844 women are diagnosed with cervical cancer and 67,477 die from the disease. This study was done with the aim of studying the expression of p53 in pre-malignant squamous epithelial lesions of cervix.Methods: Patients coming to our institution who are undergoing biopsy for abnormal cytology/colposcopy were included in the study. Total of 39 patients were studied. Immunohistochemistry was used to study the p53 expression in cervical intra-epithelial lesions.Results: Out of 39 patients studied, p53 positivity was found in CIN 1 in38.5% cases, CIN 2 and CIN 3

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Saha, Rama, Deepika Pandey, Santosh Kumar Mondal, Tummidi Santosh, Sujaya Mazumder, and Indranil Chakrabarti. "A retrospective study on cervical cancer screening- In a newly opened tertiary care Centre in Eastern India." IP Journal of Diagnostic Pathology and Oncology 8, no. 2 (2023): 83–88. http://dx.doi.org/10.18231/j.jdpo.2023.018.

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: One of the most prevalent cancers, cervical cancer is also the leading cause of mortality for women in underdeveloped nations. A fundamental test for finding infections and precancerous diseases is the Papanicolaou smear. This study aims to comprehend the function of cervical screening in detecting premalignant, malignant, and non-neoplastic lesions as well as the prevalence of different lesions in women who received a traditional pap smear technique. We screened women in the age group of 15-70 years who attended the Outpatient department of the Obstetrics and Gynaecology department of AIIMS

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Sandhu, Parminder J. S., Sarita Nibhoria, Vaneet K. Sandhu, and Harpreet Kaur. "Immunohistochemical expression of p16INK4a in premalignant lesions and malignant tumours of cervix." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 12, no. 6 (2023): 1813–19. http://dx.doi.org/10.18203/2320-1770.ijrcog20231561.

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Background: Cervical carcinoma is the third most common cancer in women worldwide and firth most common cause of cancer related deaths. Human Papilloma virus, the most common cause of cervical cancer, causes functional inactivation of pRb, resulting in overexpression of p16INK4a. The overexpression of p16INK4a correlates well with the degree of cervical dysplasia and neoplasia. The present study is done to determine the IHC expression of p16INK4a so that it may be used as a biomarker for HPV and may play a role in the prevention, diagnosis and prognosis of cervical neoplasm. Methods: The prese

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Saleh, Tareq, Nisreen Himsawi, Amani Al Rousan, et al. "Variable Expression of Oncogene-Induced Senescence/SASP Surrogates in HPV-Associated Precancerous Cervical Tissue." Current Issues in Molecular Biology 46, no. 12 (2024): 13696–712. https://doi.org/10.3390/cimb46120818.

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Oncogene-induced senescence (OIS) is a form of cellular senescence triggered by oncogenic signaling and, potentially, by infection with oncogenic viruses. The role of senescence, along with its associated secretory phenotype, in the development of cervical cancer remains unclear. Additionally, the expression of the senescence-associated secretory phenotype (SASP) has not yet been explored in cervical premalignant lesions infected by the Human Papilloma Virus (HPV). This study aimed to investigate the expression of OIS and SASP markers in HPV-infected cervical precancerous lesions. We used a se

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Priyanka, R., R. Hariprasad, V. Kumar, et al. "Relationship Between Smokeless Tobacco and Cervical Premalignant and Malignant Lesions Among the Patients Screened for Cervical Cancer in the Health Promotion Clinic, Noida." Journal of Global Oncology 4, Supplement 2 (2018): 32s. http://dx.doi.org/10.1200/jgo.18.41100.

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Background: Global Adult Tobacco Survey (GATS-2) India (2016-17), reported that 5.1 crore rural women and 1.4 crore urban women use tobacco in any form. Cervical cancer is the second most common cancer in India among women accounting for 22.86% of all cancer cases in women and 12% of all cancer cases in both men and women. One woman dies of cervical cancer every 8 minutes in India. The risk of cervical intraepithelial neoplasia (CIN) was found to be increased with the women who smoke but the association between smokeless tobacco (SLT) and areca nut have not been adequately reported in the lite

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Shiksha, Rabha Dharitri, and Prasad Mahesh. "Histopathological Study of Cervical Lesions in a Tertiary Care Centre." International Journal of Pharmaceutical and Clinical Research 16, no. 5 (2024): 1846–50. https://doi.org/10.5281/zenodo.12772374.

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<strong>Background:</strong> Cervical lesions represent a significant health concern due to their potential progression to cervical cancer, a leading cause of morbidity and mortality in women. Histopathological examination remains a cornerstone in the diagnosis and management of these lesions, providing critical insights into their nature and progression. <strong>Aim:</strong> This research intends to evaluate the histopathological patterns of cervical lesions in female patients attending a tertiary care centre, thereby contributing to improved diagnostic and therapeutic strateg

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Blanco, Rancés, and Juan P. Muñoz. "HPV and HCMV in Cervical Cancer: A Review of Their Co-Occurrence in Premalignant and Malignant Lesions." Viruses 16, no. 11 (2024): 1699. http://dx.doi.org/10.3390/v16111699.

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Cervical cancer remains a significant global health concern, particularly in low- and middle-income countries. While persistent infection with high-risk human papillomavirus (HR-HPV) is essential for cervical cancer development, it is not sufficient on its own, suggesting the involvement of additional cofactors. The human cytomegalovirus (HCMV) is a widespread β-herpesvirus known for its ability to establish lifelong latency and reactivate under certain conditions, often contributing to chronic inflammation and immune modulation. Emerging evidence suggests that HCMV may play a role in various

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Teka, Brhanu, Kyoko Yoshida-Court, Ededia Firdawoke, et al. "Cervicovaginal Microbiota Profiles in Precancerous Lesions and Cervical Cancer among Ethiopian Women." Microorganisms 11, no. 4 (2023): 833. http://dx.doi.org/10.3390/microorganisms11040833.

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Although high-risk human papillomavirus infection is a well-established risk factor for cervical cancer, other co-factors within the local microenvironment may play an important role in the development of cervical cancer. The current study aimed to characterize the cervicovaginal microbiota in women with premalignant dysplasia or invasive cervical cancer compared with that of healthy women. The study comprised 120 Ethiopian women (60 cervical cancer patients who had not received any treatment, 25 patients with premalignant dysplasia, and 35 healthy women). Cervicovaginal specimens were collect

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Sahin, Bugra, Dagistan Tolga Arioz, Mine Kanat-Pektas, Cigdem Ozdemir, and Gizem Cura. "Efficiency of p16 and Ki-67 immunostaining for detecting premalignant cervical lesions in high risk population." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, no. 7 (2021): 2578. http://dx.doi.org/10.18203/2320-1770.ijrcog20212642.

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Background: This study aimed to evaluate the efficiency of immunostaining with p16 and Ki-67 in cervical cytology specimens for the detection of cervical intraepithelial neoplasia (CIN) in a high risk population.Methods: This was a prospective review of 287 women who underwent pap smear, human papilloma virus (HPV) testing and colposcopy examination, respectively. There were cervical smear abnormalities in 108 women (37.6%) and 141 patients (49.1%) tested positive for HPV. Cervical biopsy revealed normal cervix in 28 patients (9.75%), cervicitis in 48 patients (16.72%), CIN1 in 178 patients (6

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Akinwunmi, B., I. Morhason-Bello, J. Akinyemi, et al. "O29 Premalignant cervical lesions in treatment experienced HIV positive women." International Journal of Gynecology & Obstetrics 107 (October 2009): S101. http://dx.doi.org/10.1016/s0020-7292(09)60401-x.

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Velázquez-Márquez, Noé, Gerardo Santos-López, Lucio Jiménez-Aranda, Julio Reyes-Leyva, and Verónica Vallejo-Ruiz. "Sialyl Lewis x expression in cervical scrapes of premalignant lesions." Journal of Biosciences 37, S1 (2012): 999–1004. http://dx.doi.org/10.1007/s12038-012-9261-z.

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Purwar, Shashank, Shipra Gupta, Julie Hansa John, Priyal Gupta, and Ajay Halder. "Study to Determine Concordance between High-Risk Human Papilloma Virus DNA Detection in Self Collected First Voided Urine Samples and Health-Care Worker Collected Cervical Samples in a Subset of Women with Proven Histopathological Precancerous and Cancerous Lesions of the Cervix." Journal of Mid-life Health 14, no. 1 (2023): 8–14. http://dx.doi.org/10.4103/jmh.jmh_251_22.

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ABSTRACT Objective: The objective of our study was to assess whether urinary samples for human papilloma virus (HPV) detection are a good predictive marker of cervical cancerous and precancerous lesions, by comparing against results from cervical scrapings as the gold standard test. Materials and Methods: The study is a hospital-based cross-sectional study wherein symptomatic women were screened at the colposcopy clinic. Paired samples-cervical scrapings/washings and urine samples were tested for hr-HPV for women who were found to harbor premalignant and malignant lesions of the cervix in hist

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Bagga, Neha, Poonam Elhence, Meenakshi Rao, et al. "A prospective study of cervical lesions diagnosed by liquid based cytology in Western Rajasthan, India population." International Journal of Research in Medical Sciences 7, no. 12 (2019): 4573. http://dx.doi.org/10.18203/2320-6012.ijrms20195521.

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Background: Carcinoma cervix is the second most common malignancy of women in India after breast cancer. The present study was conducted to determine the spectrum of cervical lesions by liquid-based cytology in Western Rajasthan population.Methods: It is a Prospective study on 1087 cervical samples carried over a period of 1 year. Cervical samples were taken and processed by SurePath™ LBC.Results: Of total 1087 cases 959 were negative for intraepithelial lesion or malignancy (88.22%). 88 cases (8.09%) were reported as unsatisfactory. Among the non- neoplastic cases- bacterial vaginosis was rep

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Cortés-Sarabia, Karen, Luz Del Carmen Alarcón-Romero, Miguel Ángel Mendoza-Catalán, Juan Carlos Carpio-Pedroza, Eduardo Castañeda-Saucedo, and Carlos Ortuño-Pineda. "REST/NRSF Silencing Modifies Neuronal Gene Expression in siRNA-Treated HeLa Cells: A Preliminary Exploration in the Search for Neuronal Biomarkers of Cervical Cancer." Medicina 59, no. 3 (2023): 537. http://dx.doi.org/10.3390/medicina59030537.

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Background and Objectives: REST (RE1-silencing transcription factor) diminution is associated with transcriptional relaxation, neuropeptide overexpression, and phenotype redefinition in neuroendocrine cancers, but this effect has barely been studied in cervical cancer (CC). We previously reported reduced expressions of REST in samples with premalignant lesions and CC; however, the transcriptional consequences for neural genes associated with reduced REST expression in CC are unknown. Therefore, the objective of this work was to evaluate the expression of neuronal genes in cancerous cells with

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