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Dissertations / Theses on the topic 'Premalignant'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Zhang, Li. "Proliferation, differentiation and apoptosis in human oral premalignant and malignant lesions." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0004/MQ37675.pdf.

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2

Santosh, Neetha. "Expression of Cornulin, DPEP1, SOX4 and BUB3 in Oral Premalignant Lesions." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1467329505.

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3

Steinbeck, Rüdiger G. "Mitotic failure and genome stability in benign, premalignant and malignant human tissues /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980611stei.

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4

Mui, Kin-cheong, and 梅堅祥. "Inactivation of DNA match repair proteins in premalignant lesions in Lynch syndrome." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44659635.

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5

McConnell, Dynes Tracey. "Vulval squamous cell carcinoma and premalignant skin conditions : a population-based study." Thesis, University of Aberdeen, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301229.

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Incidence trends for invasive and non-invasive disease are explored. A nested case control study of those women who progress from non-invasive disease to carcinoma is performed. The incidence of vulval carcinoma in Grampian remains stable. Incidence rates of all non-invasive chronic vulval skin disorders, regardless of underlying aetiology are rising dramatically. Age specific incidence rates suggest that there may be significant ascertainment bias in rising incidence rates for each of these skin disorders. No distinction could be found between the relative risks for women with vulval litchen

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6

Yap, Jason Ker Wei. "Improving the outcome of patients with premalignant and malignant disorders of the vulva." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6533/.

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Research presented in this thesis was driven by the need to identify risk factors that predict local recurrence (LVR) in patients with vulval cancer (VSCC), and the need for more effective treatments for women with vulvar intraepithelial neoplasia (VIN). To identify the risk factors that predispose women to LVR, a multivariate analysis was performed on a well-characterized cohort of women treated for VSCC. This analysis revealed that the only independent predictor of LVR was the presence of Lichen Sclerosis (LS). These women were five times more likely to recur than those without LS. VIN is a

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7

Hamdoon, Z. G. "The clinical application of optical coherence tomography for head and neck premalignant/malignant lesions." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1402413/.

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The principle of Optical Coherence Tomography (OCT) is based on the property of light coherence. OCT generates cross-sectional images of two-dimensional objects to obtain in-vitro and in-vivo images of tissues. Non–commercially available OCT systems, which have a higher resolution and scanning rate, have been previously reported. However, some clinical research has already been conducted using the first commercially available OCT device (Niris system) to image the larynx; but applications on oral and skin tissue have not been tested yet. This thesis aims to explore, compare and validate three

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8

Weir, Lucinda Roberta. "An immunohistochemical and molecular study of putative premalignant liver cell populations induced by Aflatoxin B1." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/29536.

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Alterations in the phenotypic and genotypic expression in foci of altered hepatocytes (FSH) and tumours in livers of rats treated with aflatoxin B1 (AFB1) were analysed. Expression of the phase I and phase II drug metabolising enzymes, P450 2C11, glutathione S-transferase (GST) 7-7, -glutamyl transferase and novel aldehyde reductase, with high activity towards AFB1-dihydrodiol, were examined. A monoclonal antibody recognising GST Yc2, a phase II enzyme which displays high conjugating activity towards the AFB1-epoxide, was prepared and used to determine its expression in AFB1 treated livers. Ti

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9

Krupnik, Eduardo. "Evaluation of premalignant lesions of rat colon by [1]H nuclear magnetic resonance and infrared spectroscopy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ35043.pdf.

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10

Odunsi, Adekunle Omatayo. "Immunogenetic analysis of HLA Class II in premalignant disease of the cervix and correlation with HPV status." Thesis, Open University, 1999. http://oro.open.ac.uk/54556/.

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The human papilloma virus (HPY) infection has a causal association with cervical intraepithelial neoplasia (CIN) and cervical cancer. However, pre-malignant or malignant transformation is not always observed with HPY infection. lILA molecules are important in the regulation of the immune response to foreign antigens. The role of genetic variation at the HLA class II loci (DR and DQ) in CIN was investigated in 176 British Caucasian patients and 420 controls (normal cervical cytology and negative for HPY 16, 18, 31 and 33). HLA DQB 1 *03 typing was performed by a novel polymerase chain reactionr

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11

Cheung, K.-John J. "Comparison of LOH profile of oral premalignant lesions from low-risk sites with those from high-risk sites." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq37499.pdf.

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12

Melville, D. M. "The cancer risk in ulcerative colitis : the accuracy of markers of premalignant change and their value in clinical practice." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235940.

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13

Teixeira, Lívio António Neves. "Lesões pré-malignas." Master's thesis, [s.n.], 2015. http://hdl.handle.net/10284/5123.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária<br>O cancro oral é a forma de cancro mais comum da cabeça e pescoço, e nos últimos anos, tem-se observado ao aumento da sua incidência, bem como, aumento da sua mortalidade. Numa fase inicial do carcinoma espinocelular oral, a forma mais prevalente de cancro oral, as manifestações clínicas e os sintomas são mínimos, sendo por isso importante o conhecimento por parte do médico dentista desta patologia, para o seu diagnóstico atempado e t

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14

Bais, Aagje Gertiene. "Risk reduction by HPV-testing in women with premalignant cervical lesions studies of clinical management and observations on the immunological background /." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10489.

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Thesis Erasmus University Rotterdam.<br>Chapters 2.1, 2.2 and 4 are preprints of articles accepted for publication in the International Journal of Cancer, Wiley Inc.. ook verschenen in gedrukte versie. With bibliogr., with a summary in Dutch.

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15

Zwick, Dr Jared C. "Topical Application of a Bioadhesive Black Raspberry Gel Modulates Gene Expression and Reduces Cyclooxygenase 2 Protein in Human Premalignant Oral Lesions." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1232653286.

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16

Addae, Haleema. "The impact of positive margins and crypt involvement in excisional procedures of the cervix on recurrence rates of premalignant diseases of the cervix." Master's thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/33427.

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BACKGROUND Recurrent disease after cervical excisional procedures has been linked to many factors. We aim to determine if positive margins and crypt involvement increased the rate of recurrence of premalignant disease in patients who had excisional procedures. METHODS In this retrospective review of the colposcopy database, patient records and pathology database, women who had cervical excisional procedures at the Groote Schuur Hospital colposcopy clinic in 2010 were followed up until 2015. Recurrence was based on high grade cytology or histology at follow up. Chi-square tests were used to com

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17

Somasekar, Amudha. "Fluorescence in situ hybridisation (FISH) analysis of chromosome 1 and gene expression levels of MAD2 and BUB1 levels in premalignant stages of gastric tissue." Thesis, Swansea University, 2011. https://cronfa.swan.ac.uk/Record/cronfa43141.

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Gastric cancer is a common cause of cancer death in the world. The mortality rate from gastric cancer is high in UK as it often presents late, often with local or distant metastasis. This makes the treatment options limited. The pathogenesis of gastric cancer occurs in a multi step pathway with pre cancerous conditions leading to cancer eventually. It is important to understand this carcinogenic process (aneuploidy and abnormal gene expression levels) and the driving forces (eg. Helicobacter pylori infection) which will enable us to alter the disease outcome. This series of experiments include

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18

Gehmert, Sebastian [Verfasser]. "The C allele of the IL-1B-511 SNP is associated with higher risk for Gastric Cancer and its premalignant lesion : a prospective case-control study in Peru / Sebastian Gehmert." Magdeburg : Universitätsbibliothek, 2012. http://d-nb.info/1052827454/34.

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19

Marques, Karine Piñera. "Lesões actinicamente induzidas em lábio inferior de pescadores: estudo clínico, cito e anatomopatológico." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-13012009-124324/.

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Este estudo propôs-se a avaliar lesões de lábio inferior de pescadores nas praias de Florianópolis, Santa Catarina, Brasil, através de análise clínica, cito e anatomopatológica. Foi realizada análise citológica de esfregaços do lábio inferior de todos os pescadores (125) cuja celularidade foi adequada (83,2% dos casos). Em 16 pescadores a avaliação clínica indicou a necessidade de biópsia, nos quais observaram-se 4 casos de lesão maligna (3,2%) e 12 de graus variados de displasia (9,6%). A análise citológica dos esfregaços não foi capaz de detectar nenhuma das alterações displásicas ou maligna

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20

Foy, Jean-Philippe. "Caractérisation transcriptomique de l’hétérogénéité des lésions à potentiel malin et des carcinomes épidermoïdes HPV-négatifs de la cavité orale." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1086.

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La morbi-mortalité élevée des carcinomes épidermoïdes de la cavité orale (CECO), qui peuvent se développer à partir de lésions orales à potentiel malin (LOPM), rend indispensable le développement de nouvelles stratégies thérapeutiques. Le décryptage de l’hétérogénéité moléculaire aux différentes étapes de la carcinogénèse orale pourrait permettre de personnaliser les stratégies thérapeutiques de prévention et de traitement de ces cancers. Notre objectif était de caractériser l’hétérogénéité transcriptomique des LOPM et des CECO.Nous avons d’abord défini des signatures transcriptomiques associé

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21

Valdman, Alexander. "A study of the transition from premalignancy to clinical prostate cancer /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-450-3/.

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22

Benton, Geoffrey Marsing. "Aerobic glycolysis: A novel signature of premalignancy in disease-free breast tissue." Diss., Search in ProQuest Dissertations & Theses. UC Only. Search in ProQuest Dissertations & Theses. UC Only, 2010. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390032.

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23

Dumont, Nancy, Yongping Crawford, Mahvash Sigaroudinia, et al. "Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy." BioMed Central, 2009. http://hdl.handle.net/10150/610113.

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INTRODUCTION:We have previously identified a rare subpopulation of variant human mammary epithelial cells (vHMEC) with repressed p16INK4A that exist in disease-free women yet display premalignant properties, suggesting that they have engaged the process of malignant transformation. In order to gain insight into the molecular alterations required for vHMEC to progress to malignancy, and to characterize the epigenetic events associated with early progression, we examined the effect of oncogenic stress on the behavior of these cells.METHODS:HMEC that express p16INK4A and vHMEC that do not, were t

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24

Seigneurin, Daniel. "Cytologie quantitative de la maturation granulocytaire dans la moelle normale et au cours des syndromes myélodysplasiques." Grenoble 1, 1987. http://www.theses.fr/1987GRE10112.

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25

Diaz, Pelaez Mauro Alejandro. "Correlación cito-histológica de lesiones premalignas del cuello uterino en pacientes atendidas en el Hospital San Bartolomé." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2014. https://hdl.handle.net/20.500.12672/11998.

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Estudia la correlación cito-histológica en las lesiones premalignas del cérvix uterino en el Servicio de Ginecología Oncológica del Hospital Nacional Docente Madre Niño San Bartolomé en el periodo comprendido entre enero a diciembre del año 2013. El estudio es observacional, descriptivo-relacional, retrospectivo de corte transversal. Se estudió a 106 pacientes atendidos en el Hospital Nacional Docente Madre Niño San Bartolomé durante el periodo de enero a diciembre de 2013. Para el análisis de las variables descriptivas cualitativas se empleó frecuencias absolutas y relativas y para el análisi

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26

Vásquez, Barahona Edinson. "Características epidemiológicas de las lesiones premalignas y malignas del cérvix en el Hospital Nacional Daniel A. Carrión 2009 - 2013." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2014. https://hdl.handle.net/20.500.12672/11948.

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El documento digital no refiere asesor<br>Determina los factores de riesgo epidemiológico relacionados con las lesiones premalignas y malignas del cérvix y sus resultados. El estudio es retrospectivo descriptivo y correlacional. El universo fue 100 pacientes como muestra, de un total de 1,226 pacientes con diagnóstico de lesión premaligna y maligna del cérvix, de la población femenina que acude al servicio de ginecología y oncología durante los años 2009 al 2013 en el Hospital Daniel A Carrión. Del 33% del resultado de biopsia es NIC de alto grado, en primer lugar, el CA IN SITU con un 16%. Y

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27

Dávalos, Salinas Héctor. "Prevalencia de lesiones gástricas premalignas o malignas diagnosticado endoscopicamente en pacientes con dispepsia, Hospital Rene Toche Groppo durante 2013-2015." Bachelor's thesis, Universidad Ricardo Palma, 2016. http://cybertesis.urp.edu.pe/handle/urp/450.

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Se ha establecido que de un total de 33 pacientes con dispepsia de 15 a 45 años, en el cual se le realizó endoscopia digestiva alta y se le encontró lesiones pre malignas o malignas, en el Hospital Rene Toche Groppo, durante enero 2013 a diciembre del 2015. La prevalencia de lesiones pre maligna es 8,4% y maligna 0,8%. El sexo más frecuente en presentar lesiones pre malignas fue el femenino (76,7%), en contraste del sexo masculino (23,3%); se observó que en las lesiones malignas el sexo masculino fue el más frecuente con el 66,67%. El síntoma clínico más frecuente fue la epigastralgia (69,7%),

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28

Escate, Herrera María Angélica. "Frecuencia, características clínicas y biopsia de lesiones malignas y premalignas de piel en el Hospital Geriátrico San José PNP, 2003-2006." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2008. https://hdl.handle.net/20.500.12672/12675.

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Da a conocer la frecuencia y las características clínicas de las lesiones premalignas y malignas de piel en los pacientes del Hospital Geriátrico San José PNP. El presente estudio de investigación es descriptivo retrospectivo transversal, se evaluaron 35 pacientes con lesiones premalignas y malignas de piel (22 del sexo femenino y 13 del sexo masculino) y que tuvieron confirmación histopatológica, atendidos durante el periodo de junio del 2003 hasta julio del 2006. Los datos obtenidos fueron evaluados a través de la estadística descriptiva con medidas de tendencia central, con desviación med

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29

Zea, Vilca Luis Felipe. "Incidencia de lesiones premalignas y malignas de ano, recto y sigmoides evaluados con el examen de proctosigmoidoscopio en el Hospital María Auxiliadora 2009-2012." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2014. https://hdl.handle.net/20.500.12672/13292.

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El documento digital no refiere asesor<br>En el presente estudio incidencia de lesiones pre malignas y malignas de ano, recto y sigmoides evaluados con el examen de proctosigmoidoscopio en el Hospital María Auxiliadora 2009-2012, no se encuentro diferencia importante entre los dos sexo; sin embargo se encontró diferencia de mayor predisposición en el sexo masculino para el examen de proctosigmoidoscopia. Las enfermedades colorectales determinadas por proctosimodoscopia. En todas las edades fueron aceptadas por todos los pacientes programados y se determinó, que los que más acuden es el grupo

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30

Mazarico, Gallego Edurne. "Relación existente entre la infección por los diferentes genotipos del Virus del Papiloma Humano y la presencia de patología premaligna y maligna del cuello uterino." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/91065.

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1) Introducción Hasta el momento se han secuenciado total o parcialmente más de 100 tipos y subtipos de VPH. De todos ellos, aproximadamente 40 tipos se han aislado en lesiones de tracto genital inferior y unos 35, según diferentes estudios, en carcinomas. Según su riesgo oncogénico, se clasifican en tipos de VPH de bajo riesgo (VPH-BR), VPH de probable alto riesgo y VPH de alto riesgo (VPH-AR). Uno de los descubrimientos más importantes en la investigación etiológica del cáncer en los últimos 25 años ha sido la demostración de que el cáncer de cuello uterino está causado por la infección

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31

Arango, Rojas Gian. "Prevalencia de Lesiones Premalignas de cáncer de Cuello uterino en los resultados de Papanicolau en las mujeres atendidas en el Hospital II – Cañete en el periodo Julio 2014 – Julio 2015." Bachelor's thesis, Universidad Ricardo Palma, 2016. http://cybertesis.urp.edu.pe/handle/urp/489.

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Objetivo: Determinar la prevalencia de las lesiones premalignas de cáncer de cuello uterino en los resultados de Papanicolau en las mujeres atendidas en el Hospital II Cañete en el periodo Julio 2014 a Julio del 2015. Métodos: Se realizó un estudio observacional, de tipo descriptivo, retrospectivo. La población, y muestra fue de 3061 resultados de Papanicolau, y fue recolectado por medio de una ficha simple de recolección de datos. Resultados: El estudio obtuvo 136 resultados de Papanicolau positivos, de los cuales 104 presentaron algún grado de alteración citológica, lo cual representó una pr

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32

Bolon, Caranhac Isabelle. "Expression des protéases matricielles et du facteur de transcription c-ets-1 au cours de la progression des cancers bronchiques." Université Joseph Fourier (Grenoble ; 1971-2015), 1996. http://www.theses.fr/1996GRE10101.

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Premiere cause de mortalite par cancer dans le monde, les cancers bronchiques se distinguent des autres cancers par leur detection tardive, un potentiel metastatique imprevisible pour la plupart des tumeurs operables de petits stades et un pronostic sombre avec les therapeutiques actuelles (10% de survie a 5 ans). Aucune des alterations phenotypiques et genetiques (activation des genes myc, inactivation des genes p53 et rb) precedemment identifiees au sein du groupe de recherche sur les cancers bronchiques n'est correlee au pouvoir metastasiant de ces tumeurs. L'objectif de ce travail etait do

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33

Carvalho, Filipa Baptista Neto Viegas de. "A terapêutica fotodinâmica nos tratamentos das lesões potencialmente malignas e cancro da cavidade oral." Master's thesis, [s.n.], 2015. http://hdl.handle.net/10284/5239.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária<br>A terapia fotodinâmica (PDT, do inglês, photodynamic therapy) é uma opção terapêutica recente e valiosa, dirigida para a destruição das células tumorais, com potencial para ser incluída no tratamento principal de combate ao cancro, bem como adjuvante de outras terapêuticas. Atualmente é considerada uma estratégia terapêutica de sucesso, clinicamente, aprovada para o tratamento de lesões potencialmente malignas (LPM) e malignas da cavi

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34

Guillen, Reveles Hector Rogelio, and Madrigal Migdania Martínez. "Concordancia diagnostica de las lesiones premalignas de cérvix de acuerdo a la colpoposcopia e histología en pacientes que acuden a la clínica de colposcopia en el hospital materno perinatal Mónica Pretelíni Sáenz del 01 de enero a 31 de diciembre del 2012." Tesis de Licenciatura, Medicina-Quimica, 2014. http://ri.uaemex.mx/handle/123456789/14841.

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Poh, Catherine Fang-Yeu. "Microsatellite studies of oral cancer and premalignant lesions." Thesis, 2001. http://hdl.handle.net/2429/13772.

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Oral squamous cell carcinoma (SCC) is believed to progress through sequential stages of premalignancies to invasive cancer. Once SCC is formed, the prognosis is poor. The 5-year survival rate of less than 50% is one of the worst among major human cancers. One of the essential keys to improving this gloomy prognosis lies in early diagnosis and proper management of premalignant lesions. A central dogma of carcinogenesis is that alteration to critical control genes underlies malignant transformation. A major focus of this thesis was to study early molecular pathways of oral cancer development and

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Chen, Wei-Chuan, and 陳韋全. "Association of human papillomavirus with oral buccal mucosa premalignant lesions." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/16252236645144340928.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>96<br>Background Buccal squamous cell carcinoma (SCC) is the most common oral malignant tumor in Taiwan. Betel quid (BQ) chewing is the most important risk factor for the buccal mucosal carcinogenesis. Previous studies showed that human papillomaviruses (HPVs), particularly high-risk HPVs, play an important role in the development of oral SCCs (OSCCs), especially the non-oral habits (OH)-associated OSCCs. Materials and methods To evaluate the etiologic role of HPVs in buccal mucosal carcinogenesis, DNA samples were purified from 100 buccal premalignant lesions, incl

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37

"Transcriptome and Metabolic Profiling of Premalignant Progression in Barrett's Esophagus." Doctoral diss., 2014. http://hdl.handle.net/2286/R.I.25152.

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abstract: Cell-cell interactions in a microenvironment under stress conditions play a critical role in pathogenesis and pre-malignant progression. Hypoxia is a central factor in carcinogenesis, which induces selective pressure in this process. Understanding the role of intercellular communications and cellular adaptation to hypoxia can help discover new cancer biosignatures and more effective diagnostic and therapeutic strategies. This dissertation presents a study on transcriptomic and metabolic profiling of pre-malignant progression of Barrett's esophagus. It encompasses two methodology deve

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Chen, Wei-Chuan. "Association of human papillomavirus with oral buccal mucosa premalignant lesions." 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-1207200814125400.

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An, Ding. "Allelic imbalance at 11q in oral cancer and premalignant lesions." Thesis, 2002. http://hdl.handle.net/2429/12316.

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Oral squamous carcinomas (SCC) remain a significant public health problem worldwide despite advances in therapy and local disease control. New innovative strategies must be developed for the prevention, early detection and treatment of oral carcinoma. Such approaches will be heavily dependent on a better understanding of the molecular mechanisms underlying carcinogenesis at this site. This thesis describes a series of studies done on oral cancers and premalignant lesions to better define the role of alterations on chromosome 11 in the development of oral cancer at this site. Although nu

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Chen, Zeng-jyun, and 陳宗儁. "Expression of premalignant genes in drug-induced senescent leukemic cells." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/75716773491398339594.

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碩士<br>輔英科技大學<br>生物技術系碩士班<br>98<br>Cell senescence is a specialized form of terminal differentiation characterized by reduced repair and regeneration of damaged or lost cells and permanent arrest in G1 phase. Hence, it has been suggested that cell senescence is a beneficial tumor suppressor mechanism through the actions of mediators of senescence. During the development of cancer, autophagy was activated by various environmental stresses. Autophay activation has been observed in cancer therapies using cytotoxic drugs and target therapies. Therefore, in this study, K562 and THP-1 cells were

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Yen, Ching-Yu, and 顏欽堉. "Malignant transformation oral premalignant tumor, and second primary oral cancer research." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/u3wf56.

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42

LAI, CHIH-YI, and 賴志毅. "Quantitative analysis of microvessels in oral premalignant lesions and squamous cell carcinoma." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/69343709723975981063.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>89<br>Background : Angiogenesis is necessary for tumor growth and metastasis. lt has been shown to correlate with tumor size, metastatic potential or prognosis in breast , lung, prostate and other cancers. Studies in head and neck cancers have suggested a similar correlation, but results have been inconclusive . This study was performed to determine whether angiogenesis occurs in oral premalignant lesions and oral squamous cell carcinomas. (OSCCs) in betel nut chewers and tobacco smokers. Method : This study used anti-CD31(anti-JC/70A) immunostaining to

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CHIANG, MENG-LING, and 蔣孟玲. "Expression of Apoptosis-associated Proteins in Oral Premalignant Lesions and Squamous Cell Carcinomas." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/81658748897490462131.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>88<br>In this study, we used the streptavidin-biotin immunohisto-chemical method to study the expressions of the apoptosis-associated proteins（BCL-2、BCL-XL、MCL-1、BAX、BAK and P53）in 69 cases of oral squamous cell carcinoma（OSCC）（experimental group）, 26 cases of epithelial hyperkeratosis（EH）, 43 cases of epithelial dysplasia（ED）（disease control groups）, and 16 cases of normal oral mucosa（NOM）（normal control group）. The expressions of the apoptosis-associated proteins in OSCCs were further correlated with the clinicopathological parameters and the prognosis of the OSCC

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Camassola, Breda Julia. "Identifying mutational landscape and inflammatory pathways associated with lung squamous premalignant lesion progression." Thesis, 2020. https://hdl.handle.net/2144/41124.

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Lung cancer is the leading cause of death among all cancer types, and a subtype of lung cancer known as lung squamous cell carcinoma (LUSC) is the second most predominant subtype accounting for ~30% of all lung cancer cases. Lung cancer is typically diagnosed at advanced stages, resulting in poor prognosis with a 5-year survival rate of 19% between 2008 and 2014 (Siegel et al., 2019). The lung cancer genome has extensively been profiled in part by The Cancer Genome Atlas (TCGA), identifying mutational signatures and revealing the contributions of tumor microenvironment. TCGA work has enabled t

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Ng, Samson Pak Yan. "Use of autofluorescence in the detection of oral premalignant lesions in high-risk populations." Thesis, 2004. http://hdl.handle.net/2429/15698.

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Objectives: The current gold standard and more recent molecular markers in prediction of cancer risk for oral premalignant lesions (OPLs) rely upon biopsy samples of the OPLs. 'Clinicians' decision of when and where to biopsy would therefore heavily influence the results of histology and molecular markers. Unfortunately current clinical parameters used to make such decisions are far from adequate. The, objective of this thesis was to establish a multi-spectral fluorescent visualization (FV) technique and examine the potential role of FV as a visual aid to identify high-risk OPLs by exami

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Hwa, Tseng Jui, and 曾瑞華. "Keratin profile of the human oral mucosa in premalignant lesions and squamous cell carcinoma." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/91879127275862081118.

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Su, Wang-yu, and 蘇旺裕. "Community-Based Screening for Oral Premalignant Lesions using Toluidine Blue dye staining – A Randomized Controlled Trial." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/01113231493697780611.

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碩士<br>國立臺灣大學<br>預防醫學研究所<br>94<br>[Background] Oral squamous cell carcinoma is now the seventh highest type of malignancy in Taiwan. Incidence of oral cancer has continued to increase parallel to the consumption of betel quid since 1980s and with a similar but lesser extent of the consumption of tobacco. Long preclinical detectable phase in oral permalignant lesions (OPL), including oral submucous fibrosis, homogenous leukoplakia, non-homogenous leukoplakia, and erythroplakia, almost preceded the advent of clinical manifest oral cancer. Consequently, with proper screening, these OPLs could be d

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Huang, Han-Chun, and 黃涵君. "The investigation of high-order interactions among environmental factors and genetic polymorphisms on oral premalignant lesions." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/74710014727518714697.

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Chen, Hui-Chun, and 陳惠群. "Design of a 5-Aminolevulinic Acid Delivery System for Photodynamic Diagnosis of Oral Premalignant and Malignant Lesions." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/41795636301287165718.

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碩士<br>台北醫學院<br>生物醫學材料研究所碩士班<br>90<br>Two kinds of spectrofluorometric methods are currently under investigation for disease diagnosis: autofluorescence and photosensitizer fluorescence. Autofluorescence may directly reveal the biochemical as well as morphological changes, and its application in cancer diagnosis is mainly restricted to the instrumental sensitivity and resolution. Photosensitizer fluorescence, on the other hand, generates better signal to noise ratio since more photosensitizer is located at the disease site. 5-aminolevulinic acid （ALA）is one of the most popular chemicals for

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Hsuen, Shui-Sang, and 薛水上. "Inducible Nitric Oxide Synthase Expression in Human Oral Premalignant and Malignant Epithelial Lesions and DMBA-Induced Hamster Buccal Pouch Carcinomas：Immunohistochemical and RT-PCR Studies." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/87567596680480882072.

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碩士<br>高雄醫學大學<br>牙醫學研究所<br>89<br>Nitric oxide (NO) plays a key role in the processes of inflammation and carcinogenesis. Three isoforms of nitric oxide synthase (NOS) have been identified: endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (iNOS). To date, most cancer studies are concerned with iNOS. The role of iNOS in the oral carcinogenesis remains to be elucidated. The purpose of the present study is to investigate the immunohistochemical and mRNA expression of iNOS in human oral premalignant & malignant epithelial lesions and DMBA-induced hamster buccal carcinomas. Thirty-three

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