Relevant bibliographies by topics / Prenol kinases

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Prenol kinases'

Author: Grafiati
Published: 25 May 2024
Last updated: 31 July 2025

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Journal articles on the topic "Prenol kinases"

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Crispim, Marcell, Ignasi Bofill Verdaguer, Agustín Hernández, et al. "Beyond the MEP Pathway: A novel kinase required for prenol utilization by malaria parasites." PLOS Pathogens 20, no. 1 (2024): e1011557. http://dx.doi.org/10.1371/journal.ppat.1011557.

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A proposed treatment for malaria is a combination of fosmidomycin and clindamycin. Both compounds inhibit the methylerythritol 4-phosphate (MEP) pathway, the parasitic source of farnesyl and geranylgeranyl pyrophosphate (FPP and GGPP, respectively). Both FPP and GGPP are crucial for the biosynthesis of several essential metabolites such as ubiquinone and dolichol, as well as for protein prenylation. Dietary prenols, such as farnesol (FOH) and geranylgeraniol (GGOH), can rescue parasites from MEP inhibitors, suggesting the existence of a missing pathway for prenol salvage via phosphorylation. I
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Lee, Miriam, William Wickner, and Hongki Song. "A Rab prenyl membrane-anchor allows effector recognition to be regulated by guanine nucleotide." Proceedings of the National Academy of Sciences 117, no. 14 (2020): 7739–44. http://dx.doi.org/10.1073/pnas.2000923117.

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Membrane fusion is catalyzed by conserved proteins R, Qa, Qb, and Qc SNAREs, which form tetrameric RQaQbQc complexes between membranes; SNARE chaperones of the SM, Sec17/αSNAP, and Sec18/NSF families; Rab-GTPases (Rabs); and Rab effectors. Rabs are anchored to membranes by C-terminal prenyl groups, but can also function when anchored by an apolar polypeptide. Rabs are regulated by GTPase-activating proteins (GAPs), activating the hydrolysis of bound GTP. We have reconstituted fusion with pure components from yeast vacuoles including SNAREs, the HOPS (homotypic fusion and vacuole protein sortin
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Qiu, Cong, Yang Liu, Yangbao Wu, Linguo Zhao, and Jianjun Pei. "Functional Characterization and Screening of Promiscuous Kinases and Isopentenyl Phosphate Kinases for the Synthesis of DMAPP via a One-Pot Enzymatic Cascade." International Journal of Molecular Sciences 23, no. 21 (2022): 12904. http://dx.doi.org/10.3390/ijms232112904.

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Dimethylallyl diphosphate (DMAPP) is a key intermediate metabolite in the synthesis of isoprenoids and is also the prenyl donor for biosynthesizing prenylated flavonoids. However, it is difficult to prepare DMAPP via chemical and enzymatic methods. In this study, three promiscuous kinases from Shigella flexneri (SfPK), Escherichia coli (EcPK), and Saccharomyces cerevisiae (ScPK) and three isopentenyl phosphate kinases from Methanolobus tindarius (MtIPK), Methanothermobacter thermautotrophicus str. Delta H (MthIPK), and Arabidopsis thaliana (AtIPK) were cloned and expressed in Escherichia coli.
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Lundquist, Peter K., Anton Poliakov, Lisa Giacomelli, et al. "Loss of Plastoglobule Kinases ABC1K1 and ABC1K3 Causes Conditional Degreening, Modified Prenyl-Lipids, and Recruitment of the Jasmonic Acid Pathway." Plant Cell 25, no. 5 (2013): 1818–39. http://dx.doi.org/10.1105/tpc.113.111120.

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Yong, Jun, Shanshan Tang, Lin Yu, Meng Li, Fang Zhang, and Xiujie Fan. "Prenyl diphosphate synthase subunit 2 is downregulated in abdominal aortic aneurysm and retards the progression of abdominal aortic aneurysm." Cytojournal 21 (December 13, 2024): 63. https://doi.org/10.25259/cytojournal_70_2024.

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Objective: Abdominal aortic aneurysm (AAA) is a complex and fatal vascular disease for which specific treatments are still lacking. This study explored the effect and possible mechanisms of prenyl diphosphate synthase subunit 2 (PDSS2) on angiotensin II (Ang II)-induced AAA in human vascular smooth muscle cells (VSMCs). Material and Methods: The AAA cell model was established by treating VSMCs with 1 μM Ang II for 24 h. The effect of Ang II on VSMC viability was detected by cell counting kit-8 assay. The role of PDSS2 on VSMC proliferation was examined using the 5-ethynyl-2'-deoxyuridine metho
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Grant, Benjamin M. M., Masahiro Enomoto, Sung-In Back, et al. "Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety." Science Signaling 13, no. 625 (2020): eaaz0344. http://dx.doi.org/10.1126/scisignal.aaz0344.

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KRAS4b is a small guanosine triphosphatase (GTPase) protein that regulates several signal transduction pathways that underlie cell proliferation, differentiation, and survival. KRAS4b function requires prenylation of its C terminus and recruitment to the plasma membrane, where KRAS4b activates effector proteins including the RAF family of kinases. The Ca2+-sensing protein calmodulin (CaM) has been suggested to regulate the localization of KRAS4b through direct, Ca2+-dependent interaction, but how CaM and KRAS4b functionally interact is controversial. Here, we determined a crystal structure, wh
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Wang, Yi-Xuan, Yi-Yuan Jin, Jie Wang, et al. "Icaritin Derivative IC2 Induces Cytoprotective Autophagy of Breast Cancer Cells via SCD1 Inhibition." Molecules 28, no. 3 (2023): 1109. http://dx.doi.org/10.3390/molecules28031109.

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Breast cancer is one of the most prevalent malignancies and the leading cause of cancer-associated mortality in China. Icaritin (ICT), a prenyl flavonoid derived from the Epimedium Genus, has been proven to inhibit the proliferation and stemness of breast cancer cells. Our previous study demonstrated that IC2, a derivative of ICT, could induce breast cancer cell apoptosis by Stearoyl-CoA desaturase 1 (SCD1) inhibition. The present study further investigated the mechanism of the inhibitory effects of IC2 on breast cancer cells in vitro and in vivo. Our results proved that IC2 could stimulate au
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Kollar, Peter, Tomáš Bárta, Stanislava Keltošová, et al. "Flavonoid 4′-O-Methylkuwanon E fromMorus albaInduces the Differentiation of THP-1 Human Leukemia Cells." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/251895.

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Aims. In this work we studied cytodifferentiation effects of newly characterized prenyl flavonoid 4′-O-methylkuwanon E (4ME) isolated from white mulberry (Morus albaL.).Main Methods. Cell growth and viability were measured by dye exclusion assay; cell cycle and surface antigen CD11b were monitored by flow cytometry. For the cytodifferentiation of cells the NBT reduction assay was employed. Regulatory proteins were assessed by western blotting.Key Findings. 4ME induced dose-dependent growth inhibition of THP-1 cells, which was not accompanied by toxic effect. Inhibition of cells proliferation c
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Zita, Wayne, Ségolène Bressoud, Gaetan Glauser, Felix Kessler, and Venkatasalam Shanmugabalaji. "Chromoplast plastoglobules recruit the carotenoid biosynthetic pathway and contribute to carotenoid accumulation during tomato fruit maturation." PLOS ONE 17, no. 12 (2022): e0277774. http://dx.doi.org/10.1371/journal.pone.0277774.

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Tomato (Solanum lycopersicum) fruit maturation is associated with a developmental transition from chloroplasts (in mature green fruit) to chromoplasts (in red fruit). The hallmark red color of ripe tomatoes is due to carotenogenesis and accumulation of the red carotenoid lycopene inside chromoplasts. Plastoglobules (PG) are lipid droplets in plastids that are involved in diverse lipid metabolic pathways. In tomato, information on the possible role of PG in carotogenesis and the PG proteome is largely lacking. Here, we outline the role of PG in carotenogenesis giving particular attention to tom
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Rocha, Sonia, Daniela Ribeiro, Eduarda Fernandes, and Marisa Freitas. "A Systematic Review on Anti-diabetic Properties of Chalcones." Current Medicinal Chemistry 27, no. 14 (2020): 2257–321. http://dx.doi.org/10.2174/0929867325666181001112226.

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: The use of anti-diabetic drugs has been increasing worldwide and the evolution of therapeutics has been enormous. Still, the currently available anti-diabetic drugs do not present the desired efficacy and are generally associated with serious adverse effects. Thus, entirely new interventions, addressing the underlying etiopathogenesis of type 2 diabetes mellitus, are required. Chalcones, secondary metabolites of terrestrial plants and precursors of the flavonoids biosynthesis, have been used for a long time in traditional medicine due to their wide-range of biological activities, from which
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Dissertations / Theses on the topic "Prenol kinases"

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Couillaud, Julie. "The terpene mini-path : nouvel accès aux terpènes et exploration de l'espace chimique par une cascade enzymatique originale." Electronic Thesis or Diss., Aix-Marseille, 2021. http://www.theses.fr/2021AIXM0188.

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À ce jour, les terpénoïdes constituent la classe de produits naturels la plus abondante et diversifiée avec plus de 80000 composés décrits et dont les propriétés structurales, biologiques (antibiotique, anticancéreux, antipaludique…) et physico-chimiques (arôme, parfum, colorant…) retiennent l’attention de la communauté scientifique. Cependant, leur accès est limité par une faible disponibilité par extraction à partir de sources naturelles ; une synthèse chimique souvent coûteuse et laborieuse; et des voies de biosynthèses longues. En combinant des approches bioinformatiques, statistiques, bio
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Dominguez-Escrig, J. L. "Tyrosine kinase and prenyl transferase inhibitors as potential therapeutics in urothelial carcinoma." Thesis, University of Newcastle upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427275.

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Neuser, Julia [Verfasser], Markus [Gutachter] Lange, Kai [Gutachter] Schuh, and Martina [Gutachter] Prelog. "Die Rolle der Pim-1 Kinase im Zweiten Fenster der Anästhetika-induzierten Präkonditionierung / Julia Neuser ; Gutachter: Markus Lange, Kai Schuh, Martina Prelog." Würzburg : Universität Würzburg, 2020. http://d-nb.info/1219430137/34.

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