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1

GARRE, FLORENCE. "Oedeme du prepuce d'origine medicamenteuse : a propos de deux observations du centre de pharmacovigilance de nice." Nice, 1988. http://www.theses.fr/1988NICE6512.

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Xavier, Fernanda da Silva. "Lesões proliferativas de pênis e prepúcio eqüinos." Universidade Federal de Pelotas, 2010. http://repositorio.ufpel.edu.br/handle/ri/2551.

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The lesions of the penis and prepuce of the horse can be originated by trauma, bacterial or parasitic infeccions, and mostly neoplasms, causing productive and reproductive losses. For this study, several cases of proliferative lesions in the penis and prepuce of horses from the archives of the Laboratório Regional de Diagnóstico (LRD) of the Faculdade de Veterinária da Universidade Federal de Pelotas (UFPel) were reviewed, and penial lesions were obtained from a equine slaughterhouse located in the municipality of Pelotas, Rio Grande do Sul, Brazil. The materials were classified and macroscopic and histological aspects were evaluated. The samples were categoryzed as neoplastic and non-neoplastic and informations about the age, breed, and origin of the horses and anatomic location of the lesions were noted. Nineteen cases were obtained from the LRD-UFPel archives and 18 cases were obtained from the slaughterhouse. The lesions from the LRD were predominantely neoplastic - mostly squamous cells carcinoma, located more frequently in the prepuce of adult animals. Most of these horses were from the municipality of Pelotas, RS, Brazil. The samples collected from the slaughterhouse were predominately located in the prepuce of adult or old, gray, mixed breed horses. The lesions of these horses were predominantely non-neoplastic, mostly parasitic balanoposthitis caused by myiasis. These horses were from varied regions, including several Brazilian states.
Os distúrbios que ocorrem no pênis e prepúcio do cavalo podem ser de diversas origens como lesões por trauma, infecções bacterianas e parasitárias, e principalmente neoplasmas, cursando com perdas produtivas e reprodutivas. Realizou-se um estudo retrospectivo e prospectivo de lesões proliferativas de pênis e prepúcio de eqüinos. Para tal, foi realizada uma revisão nos casos recebidos no Laboratório Regional de Diagnóstico (LRD) da Faculdade de Veterinária da Universidade Federal de Pelotas (UFPel) e foram colhidas lesões penianas em linha de abate num Frigorífico de Eqüinos em Pelotas/RS. Os materiais foram classificados e seus aspectos macroscópicos e microscópicos foram avaliados. Os resultados foram organizados categorizando-se as lesões como neoplásicas e não neoplásicas e buscaram-se informações quanto à idade, raça e procedência dos animais e localização anatômica das lesões. Foram estudados 19 casos de portadores de lesões obtidos dos arquivos do LRD-UFPel e 18 casos forma obtidos na linha de abate do frigorífico. Nos casos provenientes do LRD houve um predomínio de lesões neoplásicas, principalmente carcinoma de células escamosas, em animais adultos localizados com maior freqüência no prepúcio. Os animais na maioria provinham do município de Pelotas/RS. Nas amostras colhidas no Frigorífico, predominaram aquelas localizadas no prepúcio, em animais adultos a velhos, a maioria dos quais sem raça definida. A pelagem mais observada foi a tordilha. Predominaram as lesões não neoplásicas principalmente, dentre as quais se destacaram as balanopostites parasitárias, causadas por miíases. Os animais tinham procedências variadas, pois o frigorífico recebe animais de vários estados brasileiros.
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3

SANTOS, Maico Henrique Barbosa dos. "Diagnóstico precoce do sexo fetal de caprinos e ovinos pela ultra-sonografia." Universidade Federal Rural de Pernambuco, 2006. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5746.

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In this work the objective was to identify the fetal sex in pregnant uterus, between 5 and 10 weeks, of goats and ewes obtained in slaughterhouse. The sex was defined taking into consideration the localization of the GT and visualization of external genitalia. The uterus of goats (n = 108) and ewes (n = 64) were examined after immersion in a water containing recipient, with 6.0 and 8.0 MHz linear transducer. In single pregnancies, the correct fetal determination was 85.7% (48/56) in goats and 94.7% (36/38) in ewes and in twin pregnancies was 76.9% (40/52) in goats and 84.6% (22/26) in ewes. There is no mistake in fetal quantification and the accuracy from the all fetuses scanned was 81.5% (88/108) in goats and 90.6% (58/64) in ewes, being not observed difference (P > 0.05) between species, by analyse of standard errors of the difference among proportions. The results allow to conclude that the ultrasonography is efficient to identify previously the fetal sex in small ruminants and that the experience of operator is important to reduce and even eliminate the failures in diagnose.
Neste trabalho teve-se o objetivo de definir o melhor período para diagnosticar o sexo fetal nas espécies ovina e caprina pela ultra-sonografia em tempo real utilizando-se transdutor linear (6 e 8 MHz) por via transretal e convexo (5 e 7,5 MHz) por via transabdominal. Foram examinados 298 fetos de 223 ovelhas e 532 fetos de 334 cabras de diferentes raças, oriundos de monta natural e de transferência de embriões. No primeiro experimento foram examinados 64 úteros de ovinos e 108 de caprinos imersos em recipiente contendo água, obtendo-se acurácia de 90,6% na sexagem dos fetos ovinos e de 81,5% nos caprinos. Quanto à migração do tubérculo genital (TG) nos experimentos relativos à espécie ovina constatou-se que nos fetos originados de monta natural ocorre entre os dias 37 e 46 (42 ± 2,0) de gestação na raça Santa Inês, 38 a 51 (45,0 ± 3,0) dias na raça Damara, 36 a 45 (39,2 ± 2,3) dias nos mestiços ¾ Damara-Santa Inês, 36 a 46 (39,5 ± 2,9) dias na raça Morada Nova e de 38 a 48 (43,0 ± 2,8) dias na raça Dorper. Nos fetos provenientes de transferência de embriões congelados, a migração do TG ocorre entre os dias 42 e 52 (48,5 ± 3,3) de gestação na raça Morada Nova e de 36 a 58 (46,1 ± 4,7) dias na raça Dorper, registrandose que a migração do TG desses fetos é mais tardia (P < 0,05) do que naqueles de monta natural. Na espécie caprina, a migração do TG ocorre ente os dias 44 e 49 (46,2 ± 1,3) de gestação nos fetos da raça Anglo-nubiana, entre o 43º e o 54º (47,4 ± 6,5) dia nos da raça Boer, entre os dias 48 e 53 (50,5 ± 1,54) nos mestiços, entre os dias 41 e 51 (46,4 ± 2,1) nos da raça Alpina Americana e entre os dias 45 e 55 (48,9 ± 1,8) nos da raça Saanen. A comparação efetuada entre as duas últimas raças evidenciou que a migração do TG é mais precoce (P < 0,05) nos fetos da Alpina Americana. A acurácia da sexagem fetal dos exames repetidos, seja a intervalos de 12, 24 ou 48 horas, nas gestações simples foi de 100% em todas as raças caprinas avaliadas e de 100% em ovinos da raça Santa Inês, Damara, ¾ Damara-Santa Inês, e Dorper, sendo de 92,3% em fetos da raça Morada Nova provenientes de TE. Nas gestações múltiplas dos ovinos, a acurácia variou de 83% (dupla) a 100% (tripla) na raça Santa Inês, 50% (dupla proveniente de TE) a 92,9% (dupla proveniente de MN) na raça Morada Nova, sendo de 83% na raça Damara, 100% nos mestiços ¾ Damara-Santa Inês e 88,9% na raça Dorper,. Nos caprinos variou de 66,6% (tríplices) a 100% (duplas) na raça Anglo-nubiana, de 96,9% (duplas) a 100% (tríplices) na raça Boer, de 66,7% (tríplices) a 87,5% (duplas) na raça Alpina Americana, de 50% (quádrupla) a 80,9% (dupla) na raça Saanen, sendo de 75% nas gestações duplas dos fetos mestiços. Quanto ao exame único, a acurácia nas gestações simples, nos ovinos, foi de 100% nas raças Santa Inês, Morada Nova e Dorper. Nos caprinos foi de 100% na raça Anglo-nubiana, de 94,4% na raça Boer, de 85,7% na raça Alpina Americana, de 100% na raça Saanen e de 72% nas gestações dos fetos mestiços. Nas gestações múltiplas dos ovinos, somente a raça Santa Inês foi submetida a exame único, obtendo-se a acurácia de 85,7%. Já nos caprinos variou de 63% (tríplices) a 82,5% (duplas) na raça Anglo-nubiana, de 80,8% (duplas) a 100% (tríplices) na raça Boer, de 66,7% (tríplices) a 72,7% (duplas) na raça Saanen, sendo de 80% (duplas) na raça Alpina Americana. Nos fetos mestiços submetidos a exame único, a acurácia nas gestações duplas foi de 80% pela via transretal e de 55,3% pela via transabdominal. Os resultados permitem concluir que o método ultra-sonográfico de identificação do sexo de fetos caprinos e ovinos, visualizando o TG e a genitália externa, é eficiente a partir do 50° dia de gestação nos fetos ovinos originados de monta natural e a partir do 55º dia naqueles provenientes de transferência de embriões congelados, bem como nos fetos caprinos oriundos de monta natural. É também possível concluir que, nem sempre, a repetição de exames aumenta a acurácia da sexagem, seja porque o feto não se posiciona adequadamente para permitir a visualização das estruturas responsáveis pela sexagem ou porque não é possível identificar, principalmente nas gestações múltiplas, o sexo de todos os fetos no mesmo exame. Finalizando, ainda é possível concluir que as gestações múltiplas comprometem geralmente a acurácia da sexagem fetal e que a experiência do operador é fundamental para minimizar e até mesmo eliminar a emissão de diagnósticos equivocados.
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MANTEAUX, AGNES. "Etude de l'expression du recepteur des immunoglobulines polymeriques et de la localisation des plasmocytes a iga dans les muqueuses malphigiennes saines et condylomateuses du vagin, de l'exocol uterin et du prepuce." Besançon, 1994. http://www.theses.fr/1994BESA3012.

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5

Truchanowicz, Ewa G. "Prepulse reactivity in prepulse inhibition." Thesis, Swansea University, 2010. https://cronfa.swan.ac.uk/Record/cronfa42605.

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Prepulse inhibition (PPI) is a popular paradigm in sensorimotor gating research. In healthy individuals the weak lead stimulus (i.e., the prepulse) presentation results in a reduction in the startle probe (pulse) elicited response. The motor responses to the prepulses (prepulse reactivity, PPER) were until recently largely ignored in PPI research. There are conflicting reports about prepulse reactivity and startle response modification (SRM) associations; and personality factors relevant to SRM have not been previously examined in prepulse reactivity context. Healthy participants were drawn from university student and staff population. Three paradigms were used: unpredictable stimulus onset, predictable stimulus onset and conscious stimulus processing. The stimuli consisted of 80, 85 & 90dB prepulses and 115dB startle probe separated by 140ms inter-stimulus interval (onset to onset asynchrony). The inter-trial intervals varied between the studies. Startle responses were measured as eye blinks and recorded using surface EMG. All motor responses were quantified according to the same set of rules. Prepulse-elicited motor responses reliably appeared in all the studies and were distinct from spontaneous EMG. Some PPER characteristics exhibited stimulus intensity dependence further proving PPER validity as stimulus-driven response. Prepulse reactivity exhibited significant associations with startle response modification. PPER was a stable tendency; individuals either consistently responded to the weak lead stimuli or did not. Two types of startle response modification appeared under the conditions assumed to elicit maximal inhibition only: classical inhibition (as expected) and paradoxical prepulse facilitation. These appeared in motor responses and in conscious stimulus processing. The propensity towards the paradoxical prepulse facilitation was reduced by efficient prepulse inhibition. PPER and SRM had limited associations with personality factors, sex, or age. The predictable stimulus onset paradigm however highlighted the associations of the defensive startle response and its modification with fear and anxiety. Increased emotionality, regardless of its valence, proved detrimental to sensorimotor gating.
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6

Lind, Färnstrand Izabel. "How to Prepare for Death." Thesis, Kungl. Konsthögskolan, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kkh:diva-527.

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Abstract of Master essay - 10 HP Izabel Lind Färnstrand Mentor: Emma Kihl Examinator: Sigrid Sandström How to Prepare for Death In this essay I dwell into the failures of our moral senses in relation to the concept of death. How does modern death culture affect our way of life and our ability to take responsibility for the life and death of others? These questions are formed by these current times and affect both my art practice and my everyday life. When facing death within my family it occur- red to me that my and my family’s relationship to death is failing us. I have become frustra- ted with the fear and silence that seems too natural to my surrounding. Not being able to talk about a part of life that is inevitable seems irrational. It became clear when the lack of under- standing and acceptance of death caused relatives an immense suffering. The struggle seemed unnessesary and urged me to try to understand more, based on their deaths. Seeing how very different the experience of dying can be made me wonder what makes a ”good” death possible for some and others not. From there my interest in the topic death culture and fear emerged, and this essay touches on this in a variety of aspects. I use my personal experiences in combina- tion with thoughts of others to talk of layers of these issues through my artistic practice. This personal method is my way of trying to structure a thinking – in a way that I can use and make sense of it – with a varied level of success. I feel it is important to note that I don’t claim to have any answes. This essay is more an attempt to pose questions around human behaviour. Even though many of these ques- tions have been asked over and over again, throughout different times, I believe it is impor- tant to ask them again and again. As long as the Human is part and violently effecting this suffering world. Many of the thoughts in this essay are based on fragments of ideas by Judith Butler, espe- cielly from her book Frames of War: When is Life Grievable? (2009). I also reference Caitlin Doughty’s From Here to Eternity: Traveling the World to Find the Good Death (2017) and and Sogyal Rinpoche The Tibetan Book of Living and Dying (1992). The themes gathered that I try to make use of in this essay and in my artistic practice are purpose, fear, death, health, happiness, narcissim and resposibility.
Abstract of Artistic work How to Prepare for Death @ Galleri Mejan, Exercisplan 3, october 2019 Media: Spatial installation with a performance (1 h) Materials: Clay, plaster, metal & red plastic film How to Prepare for Death is a spatial installation in one of the gallery rooms of Galleri Mejan. The work includes the whole space of the area, such as the floor and the walls. You step into an altered reality, where the floor is covered with clay that is cracking increasingly over time and windows that are tinted red so that the air you breath seems red. When you enter your eyes need to adjust and after a while it is rather the outside that seems colored, neon green -  the complementary color of red. From the clay there are metal rods sticking out vertically, with plaster sculptures at the end. These sculptures are broken, and resemble body parts with a medical aesthetics. Similar sculptures come out from the walls, like fragile fragments of something that used to be. When you walk around the sculptures the clay crackle under your feet, and crumble into smaller pieces and dust. It is constructed as an ambivalent experience of nothingness, emptiness, ”afterness” and a sanctuary of thoughts. My questions about life and death drive me to investigate how to create spaces for these subjects to feel present, so that we can face our fears.
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Poje, Albert Buddy Filion Diane L. "The effects of multiphasic prepulse stimuli on attentional modulation of prepulse inhibition of the acoustic startle eyeblink response." Diss., UMK access, 2007.

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Thesis (Ph. D.)--Dept. of Psychology. University of Missouri--Kansas City, 2007.
"A dissertation in psychology." Advisor: Diane L. Filion. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed July 16, 2008. Includes bibliographical references (leaves 109-118). Online version of the print edition.
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Fisher, Shannon Rae. "Using technology to prepare for future scienTESTS." Diss., A link to full text of this thesis in SOAR, 2006. http://soar.wichita.edu/dspace/handle/10057/565.

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Thesis (M.Ed.)--Wichita State University, College of Education, Dept. of Curriculum and Instruction.
"July 2006." Title from PDF title page (viewed on April 25, 2007). Includes bibliographic references (leaves 36-39).
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Ali, Monzur. "New synthetic approaches to prepare degradable polymers." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444126/.

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This thesis is concerned with the synthesis of acid labile co-polymers. Two polymer systems were examined (1) polyacetals and (2) poly(ortho esters). As for poly(ortho esters), there is a need for better synthetic methods to prepare these polymers more easily without the need of stringent anhydrous conditions, with more broad structural variation, and in a more cost effective manner. Pendent functionalised polyacetals derived from PEG and tyrosine derived monomer diols have been prepared and their structure activity relationships determined. A smaller size alkyl chain on the tyrosine derived monomer diol increased the rate of degradation of these polyacetal libraries. For poly(ortho esters), a first strategy involved the preparation of novel stable orthoester monomers. The key aspect was to embed the orthoester within the monomer while providing orthogonal polymerisation functionality. This synthetic route attempts to address the synthetic limitations for the preparation of existing poly(ortho esters) and it is believed to be the first such example. The stabile symmetrical bicyclic 2.2.2 orthoester monomer molecule derived from the naturally occurring metabolite phenyl acetic acid was used to prepare the new poly(ortho esters). The bicyclic orthoester 2.2.2 ring arrangement provided the monomer with rigidity, therefore enabling a pure solid monomer to be prepared in three synthetic steps. This approach provided a more efficient polymerisation reaction that requires less stringent polymerisation reaction conditions then existing literature examples for preparing poly(ortho esters). The second broad strategy examined the synthesis of a hydrolytically stable precursor poly (oxetane esters), which underwent a pH triggered rearrangement reaction within the polymer mainchain to prepare orthoester moieties in the polymer mainchain. In conclusion these strategies have provided new synthetic examples of preparing the highly degradable acid labile polymers e.g. poly(ortho esters).
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Holcomb, Ronald E. "Harambee! working together to prepare African missionaries /." Theological Research Exchange Network (TREN), 1998. http://www.tren.com.

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Graves, Milton L. "Teaching laypeople to prepare a biblical message." Theological Research Exchange Network (TREN), 1999. http://www.tren.com.

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Main, Patty A. "How Superintendents Prepare School Districts for Change." Ohio University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou14836300290792.

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Lundin, Sverker. "Methods to Prepare DNA for Efficient Massive Sequencing." Doctoral thesis, KTH, Genteknologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-105116.

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Massive sequencing has transformed the field of genome biology due to the continuous introduction and evolution of new methods. In recent years, the technologies available to read through genomes have undergone an unprecedented rate of development in terms of cost-reduction. Generating sequence data has essentially ceased to be a bottleneck for analyzing genomes instead to be replaced by limitations in sample preparation and data analysis. In this work, new strategies are presented to increase both the throughput of library generation prior to sequencing, and the informational content of libraries to aid post-sequencing data processing. The protocols developed aim to enable new possibilities for genome research concerning project scale and sequence complexity. The first two papers that underpin this thesis deal with scaling library production by means of automation. Automated library preparation is first described for the 454 sequencing system based on a generic solid-phase polyethylene-glycol precipitation protocol for automated DNA handling. This was one of the first descriptions of automated sample handling for producing next generation sequencing libraries, and substantially improved sample throughput. Building on these results, the use of a double precipitation strategy to replace the manual agarose gel excision step for Illumina sequencing is presented. This protocol considerably improved the scalability of library construction for Illumina sequencing. The third and fourth papers present advanced strategies for library tagging in order to multiplex the information available in each library. First, a dual tagging strategy for massive sequencing is described in which two sets of tags are added to a library to trace back the origins of up to 4992 amplicons using 122 tags. The tagging strategy takes advantage of the previously automated pipeline and was used for the simultaneous sequencing of 3700 amplicons. Following that, an enzymatic protocol was developed to degrade long range PCR-amplicons and forming triple-tagged libraries containing information of sample origin, clonal origin and local positioning for the short-read sequences. Through tagging, this protocol makes it possible to analyze a longer continuous sequence region than would be possible based on the read length of the sequencing system alone. The fifth study investigates commonly used enzymes for constructing libraries for massive sequencing. We analyze restriction enzymes capable of digesting unknown sequences located some distance from their recognition sequence. Some of these enzymes have previously been extensively used for massive nucleic acid analysis. In this first high throughput study of such enzymes, we investigated their restriction specificity in terms of the distance from the recognition site and their sequence dependence. The phenomenon of slippage is characterized and shown to vary significantly between enzymes. The results obtained should favor future protocol development and enzymatic understanding. Through these papers, this work aspire to aid the development of methods for massive sequencing in terms of scale, quality and knowledge; thereby contributing to the general applicability of the new paradigm of sequencing instruments.

QC 20121126

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Wolvin, Brad. "How to prepare Australian homeland security emergency planning /." Connect to Electronic Thesis (CONTENTdm), 2009. http://worldcat.org/oclc/444638917/viewonline.

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Futvoye, Carling E. "Hope for the Best, Prepare for the Worst." Ohio University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1275497655.

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Wang, Tiaoling. "Prepare for Alzheimer’s: Narratives to bind us together." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1522337630772491.

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Parker, Stephen David. "The effects of attention and stimulus onset asynchrony on the relationship between prepulse inhibition of the startle-eyeblink and prepulse-rating inhibition /." [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16834.pdf.

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Fitt, Melynda H. "An Investigation of the Doctoral Dissertation Literature Review: From the Materials We Use to Prepare Students, to the Materials That Students Prepare." DigitalCommons@USU, 2011. https://digitalcommons.usu.edu/etd/1101.

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Practically speaking, a well-conducted review of literature is central to a scholar’s ability to pose pertinent and timely questions within their field. As part of the culminating written assessment of a Ph.D. candidate, the dissertation literature review provides a unique vantage point to explore future scholars’ preparation. In spite of its central role within the research process, research about how future scholars are taught the doctoral competencies necessary to conduct a review of the literature for the dissertation or how the dissertation literature reviews are assessed is limited. In two separate studies, this research uses the Boote and Beile’s Literature Review Scoring Rubric as a framework to explore the textbooks used in the early stages of doctoral education and the quality of dissertation literature reviews from a field of education research. In the first study, seven of the top selling education research methods textbooks from 2010 were analyzed to determine how well they cover the 12 performance criteria on the rubric. While the results were varied, the majority of textbooks were not adequate in their coverage of the performance criteria identified by Boote and Beile. In short, the materials used to prepare doctoral students may not be equal to conveying critical components of the literature review. Efforts were then devoted to a replication study of exploring the end results of doctoral training and preparation. In the second study, the Literature Review Scoring Rubric was used to assess the quality of 30 randomly selected dissertation literature reviews from Instructional Technology. The scores of the dissertation literature reviews were also varied. While some dissertation literature reviews in this study were of high quality and scored well, the majority of them were of a lower quality.
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Dubay, Anthony R. "Improving strategies to prevent and prepare for radiological attack." Monterey, California : Naval Postgraduate School, 2010. http://edocs.nps.edu/npspubs/scholarly/theses/2010/Mar/10Mar%5FDubay.pdf.

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Thesis (M.A. in Security Studies (Combating-Terrorism: Policy & Strategy))--Naval Postgraduate School, March 2010.
Thesis Advisor(s): Moltz, James Clay. Second Reader: Dahll, Erik J. "March 2010." Description based on title screen as viewed on April 26, 2010. Author(s) subject terms: Radiological Terrorislm, RDD, Dirty Bomb, Public Preparedness, WMD. Includes bibliographical references (p. 87-98). Also available in print.
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Coleman, Pheobie Latossa. "Executive Management Methods to Prepare Employees for Future Positions." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/3149.

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Creating successful leaders is one of the challenges that social services organizations are facing. Employees may lack essential managerial skills to become productive leaders, and some managers may lack viable succession planning methods for preparing employees for leadership positions. The purpose of this case study was to explore methods that executive managers use to prepare employees for leadership positions. Path-goal theory and transformational leadership represent the conceptual framework that grounded this study. Semistructured interviews were conducted with 10 executive managers in the social services industry within southwest Georgia with experiences and skills specific to implementing successful succession planning. Company archives of corporate reports, government records, and business and management records were used for triangulation. The data were coded and analyzed using a modified van Kaam method. Participants verified the accuracy of the analysis of their responses through member-checking. The findings revealed 4 emergent themes: organizational management, hiring employees that fit the culture, leadership capabilities, and talent management. A recommendation from the study was that executive managers find methods to prepare employees for leadership positions. These findings may contribute to positive social change by identifying methods to prepare employees for leadership positions, thereby generating organizational sustainability, increasing organization revenue, and creating community economic development.
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Mehta, Jimit Haresh. "Mild and Convenient Methods to Prepare N-Alkyl Tacrines." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/77010.

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Alzheimer's Disease (AD) is an irreversible, age-related neurodegenerative disorder which causes cognitive impairment and a wide variety of neuropsychiatric and behavioral disturbances. Acetylcholinesterase inhibitors (AChEI) are the mainstay for the treatment of AD. Acetylcholinesterase (AChE) catalyzes the hydrolysis of acylcholinesters with a relative specificity for acetylcholine (ACh). Observation of a deficiency of cholinergic neurotransmission in AD led to the development of AChEI as the first approved treatment for dementia symptoms. Tacrine (9-amino-1,2,3,4-tetrahydroacridine) is a reversible inhibitor of AChE. It was the first drug approved by the FDA for the treatment of cognitive symptoms of AD. Tacrine is now rarely prescribed as a drug for the treatment of AD due to its high hepatotoxicity in almost 50% of the patients. However, tacrine derivatives have considerable potential for the palliative treatment of AD. Synthesis of various bivalent tacrines led to the improvement in inhibitory potency and selectivity towards inhibition of AChE. Heptylene-linked bis-tacrine has especially shown immense promise to be an ideal AChEI. Thus dimerization of a lead compound seemed to be an ideal strategy where the compound can bind to both catalytic anionic site (CAS) and peripheral anionic site (PAS) on the AChE enzyme. However synthesis of N-alkyl derivatives of expanded tacrines like 12-chloro-2-methyl-6,7,8,9,10,11-hexahydrocycloocta[b]quinoline by the standard SNAr methods was unsuccessful and thus alternatives needed to be developed to synthesize N-alkylated and bivalent 12-chloro-2-methyl-6,7,8,9,10,11-hexahydrocycloocta[b]quinoline. Upon exploring the alternatives, N-arylation by Pd-catalysis seemed to be the most mild and convenient alternative over the standard SNAr procedures.
Master of Science
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22

Gill, Wesley. "Behavioral and Neurobiological Evidence of Epigenetic Transmission in the Neonatal Quinpirole Rodent Model of Schizophrenia." Digital Commons @ East Tennessee State University, 2005. https://dc.etsu.edu/etd/3719.

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Quinpirole is a dopamine D2 receptor agonist that if administered to rats from postnatal day (P)1-21 results in increased dopamine D2 receptor sensitivity throughout the animal’s lifetime. This increase in receptor sensitivity is consistent with schizophrenia. This model has additional consistencies with human schizophrenia, including sensorimotor gating deficits, enhanced behavioral and neurobiological responses to nicotine, and protein alterations consistent with the disorder. In this study, a second generation of the neonatal quinpirole (NQ) rodent model was created to investigate if long term changes caused by NQ treatment would be passed to offspring. NQ treated rats were mated and their offspring left untreated. To investigate if dopamine D2 receptor hypersensitivity was transmitted from the first to the second generation of the model, yawning behavior was assayed after acute quinpirole treatment. Prepulse inhibition (PPI) is a test of sensorimotor gating, and PPI testing was performed on adolescent second generation rats. Behavioral sensitization and conditioned place preference to nicotine (0.5 mg/kg and 0.6 mg/kg respectively) were examined in adolescence in both generations of the model. Several neurobiological assays were performed in both nicotine naïve and animals sensitized to nicotine (0.5 mg/kg) in order to investigate consistencies with the NQ model, which has shown enhanced responses to nicotine. These include enzyme linked immunosorbent assays (ELISAs) for brain-derived neurotrophic factor (BDNF) and cAMP response element-binding protein (CREB), as well as quantitative PCR (qPCR) to quantify messenger RNA (mRNA) of regulator of G-protein signaling 9 (rgs9). Results indicated that second generation rats of NQ-treated rats demonstrated increased yawning behavior in response to acute quinpirole treatment. PPI deficits and enhanced behavioral responses to nicotine were also observed. Increased BDNF expression was observed in the nucleus accumbens following nicotine sensitization, consistent with past work in first generation NQ-treated rats. CREB expression was also increased in both generations of the model, an effect linked to alterations in PPI and other schizophrenia-like symptomology. Rgs9 expression was generally unaltered in either generation of the model. This study provides basis for utilization of a second generation of the NQ model to study epigenetic influences in schizophrenia and drug abuse vulnerability.
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23

Swonger, Jessica M. "Prepulse Inhibition of the Startle Reflex in Forebrain Oxytocin Receptor Knockout Mice." Kent State University Honors College / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1304360430.

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24

Gill, Wesley. "Behavioral and Neurobiological Evidence of Epigenetic Transmission in the Neonatal Quinpirole Rodent Model of Schizophrenia." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etd/3719.

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Quinpirole is a dopamine D2 receptor agonist that if administered to rats from postnatal day (P)1-21 results in increased dopamine D2 receptor sensitivity throughout the animal’s lifetime. This increase in receptor sensitivity is consistent with schizophrenia. This model has additional consistencies with human schizophrenia, including sensorimotor gating deficits, enhanced behavioral and neurobiological responses to nicotine, and protein alterations consistent with the disorder. In this study, a second generation of the neonatal quinpirole (NQ) rodent model was created to investigate if long term changes caused by NQ treatment would be passed to offspring. NQ treated rats were mated and their offspring left untreated. To investigate if dopamine D2 receptor hypersensitivity was transmitted from the first to the second generation of the model, yawning behavior was assayed after acute quinpirole treatment. Prepulse inhibition (PPI) is a test of sensorimotor gating, and PPI testing was performed on adolescent second generation rats. Behavioral sensitization and conditioned place preference to nicotine (0.5 mg/kg and 0.6 mg/kg respectively) were examined in adolescence in both generations of the model. Several neurobiological assays were performed in both nicotine naïve and animals sensitized to nicotine (0.5 mg/kg) in order to investigate consistencies with the NQ model, which has shown enhanced responses to nicotine. These include enzyme linked immunosorbent assays (ELISAs) for brain-derived neurotrophic factor (BDNF) and cAMP response element-binding protein (CREB), as well as quantitative PCR (qPCR) to quantify messenger RNA (mRNA) of regulator of G-protein signaling 9 (rgs9). Results indicated that second generation rats of NQ-treated rats demonstrated increased yawning behavior in response to acute quinpirole treatment. PPI deficits and enhanced behavioral responses to nicotine were also observed. Increased BDNF expression was observed in the nucleus accumbens following nicotine sensitization, consistent with past work in first generation NQ-treated rats. CREB expression was also increased in both generations of the model, an effect linked to alterations in PPI and other schizophrenia-like symptomology. Rgs9 expression was generally unaltered in either generation of the model. This study provides basis for utilization of a second generation of the NQ model to study epigenetic influences in schizophrenia and drug abuse vulnerability.
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25

Joshua, Calvin N. "A curriculum to prepare pastors for tribal ministry in India /." Link to Dissertations, 2007. http://eprint.cc.andrews.edu/36/.

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26

Mott, Lacroix Kelly, Ashley Hullinger, Mark Apel, William Brandau, and Sharon B. Megdal. "Using Scenario Planning to Prepare for Uncertainty in Rural Watersheds." College of Agriculture, University of Arizona (Tucson, AZ), 2015. http://hdl.handle.net/10150/593579.

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10 pp.
Planning for an uncertain future presents many challenges. Thinking systematically and creatively about what is in store through a process called scenario planning can help illuminate options for action and improve decision-making. This guide focuses on a process for developing scenarios to help communities and watershed groups explore what might happen in the years to come, make more informed decisions today, and build a watershed management process. The systematic approach to scenario planning described here is based on the lessons learned through a yearlong scenario planning process in the Upper Gila Watershed in southeastern Arizona and Water Resource Research Center’s (WRRC) research on scenario planning.
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27

Friesen, Ingrid E. "You prepare a table before me responding to God's grace /." Online full text .pdf document, available to Fuller patrons only, 2001. http://www.tren.com.

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28

Kerr, Mariann. "Teaching Strategies to Prepare Prelicensure Nursing Students to Teach-back." Diss., NSUWorks, 2016. https://nsuworks.nova.edu/hpd_con_stuetd/28.

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Background: Prelicensure nursing programs prepare generalists with essential knowledge, skills, and attitudes to practice in complex health care environments. Nurse educators determine which teaching strategies will best prepare the nurse generalist. Purpose: The purpose of this study was to determine the effectiveness of a teaching plan that combined the strategies of pretest/posttest, classroom activities, and a problem-based learning activity: a clinical immersion experience. The skill of "teach-back" was taught and evaluated. Theoretical framework: Two theories guided the teaching plan for this research. Adult learning theory (Knowles, 1975, 1980, 2012) addressed how and why adults learn, and social cognitive theory (Bandura, 1977, 1986) described teaching strategies that assisted the adult learner to gain knowledge. Methods: A non-experimental design divided consenting participants were into intervention (n = 21) and control groups (n = 11). The Health Literacy Knowledge and Experience Survey (Cormier, 2006) was used to pretest/posttest for attainment of knowledge related to teach-back. The Communication Assessment Tool (Makoul, Krupat, & Chang, 2007) was used by standardized patients to evaluate the participants' ability to perform a teach-back. Results: The results of this study provided evidence that posttest scores improved for both intervention and control groups (n = 32). Twenty-seven participants performed a teach-back with evaluation. The results did not indicate a significant difference between groups in performing the skill of teach-back. Conclusion: There was little difference in posttest scores for groups and participants' ability to perform a teach-back, indicating that both groups gained knowledge and skill from the teaching strategies.
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29

Tanner, Lisa. "Effects of early acoustic stimulation on prepulse inhibition in mice." Scholar Commons, 2003. https://scholarcommons.usf.edu/etd/1490.

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The purpose of this study was to determine the effects of an atypical pattern of early acoustic stimulation on auditory development. Previous human research suggests that the acoustic environment of pre-term human infants in the Neonatal Intensive Care Unit (NICU) negatively affects some aspects of auditory development. Animal research suggests that premature auditory stimulation interrupts auditory development. Because mice are born before their auditory systems are developed, they make an excellent model for research on fetal and postnatal plasticity of the auditory system. The premature auditory state of newborn mice is similar to that of the NICU pre-term infant, albeit, natural for mice C57 mouse pups were exposed to an augmented acoustic environment (AAE) of a nightly 12-hour regiment of 70 dB SPL noise burst, beginning before age 12 days (onset of hearing) and lasting for one month. The prepulse inhibition (PPI) of mice exposed to the AAE was compared to that of non-exposed mice to observe short-term and long-term effects. Results showed that the prepulse inhibition of the AAE exposed mice did not differ significantly from that of the non-exposed mice. However, it is possible that the measurement used, PPI, may not have been appropriate or that the AAE may not have been an appropriate simulation of the NICU environment.
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30

Wray, Brenda Caroline. "Development of Novel Methods to Prepare Nitrogen and Oxygen Heterocycles." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306329847.

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31

Melén, Anton. "Case Studies: How to prepare for a complex research process." Thesis, Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-32947.

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32

Mohr, John Darrell. "Technology-mediated distance education used to prepare special education personnel." Thesis, University of North Texas, 2004. https://digital.library.unt.edu/ark:/67531/metadc4544/.

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This study examined how technology-mediated distance education is used in special education courses in teacher preparation programs. The data are based on a 30-item survey administered to members of the Teacher Education Division of the Council for Exceptional Children, who identified themselves as serving in an instructional capacity within institutions of higher education. Technology-mediated instruction was characterized in terms course delivery methods and program attributes. An analysis of instructional design processes revealed that most instructors are largely autonomous and do not rely on a team-based approach. Most make use of course-design and management software. Training is linked to course strategy and evaluation, while experience is associated with implementation. Respondents emphasized communication and student feedback. While both users and non-users of distance education technology foresaw the increased use for course delivery in the future, a notable percentage (13%) of current users indicated a desire to discontinue use.
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33

Champeau, Mathilde. "Supercritical CO2 Assisted Impregnation to prepare Drug-eluting Polymer Implants." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0205/document.

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Le procédé d’imprégnation par voie CO2 supercritique est une solution prometteuse pour préparer des implants polymère à libération contrôlée de médicaments.Ce travail a permis de comprendre l’influence des paramètres gouvernant ce procédé et de préciser dans quelle mesure ce procédé peut être utilisé pour préparer des implants polymères chargés en médicament. Pour ce faire, nous avons combiné les informations obtenues grâce aux techniques classiques de caractérisation de polymères et à un dispositif que nous avons développé basé sur la micro-spectroscopie FTIR haute pression in situ.Dans cette étude, des fils de suture de PLLA, PP and PET ont été imprégné avec deux anti-inflammatoires (aspirine et kétoprofène).Tout d’abord, l’évolution du comportement des systèmes binaires médicament/CO2 (solubilité et spéciation) et polymère/CO2 (quantité de CO2 adsorbé, gonflement de la matrice, évolution de la microstructure et des propriétés de tension du polymère) a été déterminé en fonction de la pression et de la température. Ensuite, le procédé d’imprégnation a été étudié. L’influence des conditions expérimentales sur le taux d’imprégnation a été déterminée et expliquée par la quantité de CO2 adsorbé, le gonflement de la matrice, la solubilité du médicament, l’évolution de la microstructure du polymère et aussi l’affinité médicament/polymère. La matrice de PLLA a pu être plus largement imprégnée (jusqu’à 32%) que celles de PP et PET (5% max). Enfin, l’influence des conditions d’imprégnation et de dépressurisation sur le relargage a été démontrée sur le système PLLA/Kétoprofène, la durée de relargage variant de 3jours à 3mois
The scCO2 impregnation process is a promising alternative to other manufacturing process to prepare drug-eluting polymer implants.This work enabled to rationalize the influence of the key parameters governing this process and to determine in which extent this process can be used to prepare drug-eluting implants. We have combined the information obtained with traditional polymer characterization techniques and a newly characterization set-up we have developed that is based on in situ FTIR micro-spectroscopy. We have worked on the impregnation of sutures made of PLLA, PP and PET with two anti-inflammatory drugs namely ketoprofen and aspirin.Firstly, the thermodynamic behaviors of the systems drug/CO2 (solubility and speciation of the drug) and polymer/CO2 (CO2 sorption, polymer swelling, evolution of the polymer microstructure and of the tensile properties) were studied as a function of pressure and temperature. Then, the scCO2 impregnation process was investigated. The impact of the operational conditions on the drug loading (contact time, pressure, temperature and depressurization conditions) was explored and accounted regarding to the CO2 sorption, the2swelling, the drug solubility as well as the changes in the polymer microstructure with the experimental conditions and the presence of the drug. The drug/polymer affinity was also explored. The tensile properties of the impregnated fibers were also evaluated. PLLA was more impregnated (up to 32%) than PP and PET (up to 5%) in the investigated conditions. Finally, we have shown that the drug release can be tuned from 3 days to 3 months by varying the impregnation and depressurization conditions on the system PLLA/Ketoprofen
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34

Whicker, Wyatt, W. Drew Gill, and Russell W. Brown. "DISCOVERY OF A NOVEL ANTI-NEUROINFLAMMATORY TREATMENT FOR AUDITORY SENSORIMOTOR GATING IN TWO RODENT MODELS OF SCHIZOPHRENIA." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/204.

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Schizophrenia is primarily treated with the use of antipsychotic medications. However, antipsychotics used have severe, dose-dependent side effects in schizophrenia patients. Therefore, there is a need for new adjunctive drugs that lower the effective dose of first line schizophrenia drugs and improve patient symptoms. Neuroinflammation is associated with microglial activation in schizophrenia, and increased tumor necrosis factor-alpha (TNF) has shown to be associated with Metabolic Syndrome in schizophrenia patients. A newly developed anti-neuroinflammatory, PD2024, reduces TNF-alpha action in vitro and in vivo, and has been shown to be well-tolerated in rat and dog studies with no adverse effects. The purpose of this research is to evaluate the effect of PD2024 in two well-defined schizophrenia models in rats. The neonatal quinpirole model has been established through administration of the dopamine D2-like agonist quinpirole (NQ) or saline control (NS) postnatally from days 1-21. NQ treatment results in increases of dopamine D2 receptor sensitivity throughout the animal’s lifetime without changing receptor number, mimicking a hallmark of schizophrenia. The polyinosinic:polycytidylic acid (Poly I:C) model is based on mimicking an increase immune response during early brain development, which has been shown to increase the prevalence of schizophrenia. Poly I:C (2 mg/kg) was administered during the neonatal period at postnatal days (P)5-7 to produce this effect. Both models were given PD2024 at 10mg/kg orally through the diet from P30-67. Prepulse inhibition (PPI) was used to test sensorimotor gating deficits in the rats. PPI has past research showing its use as a quantitative phenotype for evaluating schizophrenia-associated behavioral and neurobiological deficits. In our PPI test, rats are exposed to three different, randomly ordered noise trials. The trials included a pulse trial with a 120-decibel startle pulse, a prepulse trial with an auditory click at 73, 76, or 82-decibels, and a no stimulus trial without any additional noise. The rats were given 25 randomized trials, comprised of 5 pulse, 15 prepulse (5 each of 73, 76, and 82dB) and 5 no stimulus trials. Background noise was 70dB, and the rats were tested during adolescence (days 45-46) and adulthood (60-65). In NQ adolescent rats, PPI was significantly improved in the PD2024-treated compared to NQ controls. NQ-PD2024 and NS rats were statistically equivalent throughout the trials. These results were reflected in the NQ adult model as well. The Poly I:C adolescents treated with PD2024 also demonstrated improved PPI performance compared to Poly I:C controls. This improvement was also shown in the adult Poly I:C rats. Overall, the PPI deficits in both models improved between 15 to 30% in adolescence and adulthood. These results indicate that PD2024 is effective in treating schizophrenia-associated behaviors.
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35

Khan, Yasir [Verfasser]. "How can an average UK graduate prepare for retirement / Yasir Khan." München : GRIN Verlag, 2018. http://d-nb.info/1186966440/34.

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36

Viboonkiat, Runglawan. "Methods to prepare amorphous material for rapid dissolution solid dosage forms." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406229.

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37

Varty, Geoffrey Brian. "Investigations into prepulse inhibition : a proposed in vivo model for schizophrenia." Thesis, University of Hertfordshire, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309718.

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38

Ralph, Rebecca Jeanette. "Dopamine modulation of prepulse inhibition and locomotor behavior in knockout mice /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2001. http://wwwlib.umi.com/cr/ucsd/fullcit?p3001269.

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39

Wykoff, Randy, Amal Khoury, J. Michael Stoots, and Robert P. Pack. "Undergraduate Training in Public Health Should Prepare Graduates for the Workforce." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/1332.

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There has been a rapid growth in the number of programs awarding undergraduate degrees in public health and the number of students receiving such degrees (1). There has not, however, been a significant discussion of the purpose of such degree programs. What, if anything, are the recipients of these degrees being trained to do? What careers, if any, are they being prepared to enter? Is the degree designed primarily to prepare students to enter graduate training in public health or some other graduate or health professional programs? Alternatively, does the degree exist because “an understanding of public health is a critical component of good citizenship and a prerequisite for taking responsibility for building healthy societies”? (2).
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40

Landers, Kathy Michelle. "Using Simulations to Prepare for College and Careers in Information Technology." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7549.

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While simulators can be used in place of hands-on hardware, there was not a significant body of quantitative research supporting the use of simulators for college and career success at the secondary level in information technology (IT). The purpose of this quantitative, nonexperimental study was to determine if there was a significant difference in college and career readiness of New York state high school students in approved IT content cluster high school programs, between those who use simulations and those who use hands-on hardware. Kolb's theory of experiential learning was the theoretical foundation for this research. The research questions examined whether there was a significant difference in the written exam grades, the hands-on exam grades, and the certification pass rates of students, based on the percentage of simulation used in their coursework. A survey was used to collect data on 60 students. A one-way Welch ANOVA indicated no significant difference in written grades between groups. A Kruskal-Wallis ANOVA showed statistical significance between groups using all simulated labs and less than 50% simulated labs, as well as between all simulated labs and 50% or greater simulated labs for hands-on grades. Fisher's Exact Test indicated that the proportion of students in the less than 50% simulated labs group who earned industry-level certifications was statistically significantly higher than the 50% or greater simulated labs group or the all simulated labs group. Implications for social change are that workers with entry-level IT skills can fill jobs in the growing IT field that offers well-paying jobs with more promising futures.
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41

Traveler, Shagranda M. "Retention Strategies to Prepare and Maintain Talent for Future Leadership Roles." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7514.

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Retaining qualified talent is essential to organizational leaders' ability to maintain a competitive advantage. The purpose of this multiple case study was to explore the retention strategies that financial managers used to prepare and maintain talent to assume future leadership roles. The conceptual framework that grounded this study was the transformational leadership theory. The research participants were financial managers from 5 financial services businesses located in the southern region of the United States with a minimum of 5 years of management experience and at least 3 direct reports. Data were collected from semistructured interviews, observations, and review of annual reports, websites, and talent-development strategies. To ensure data saturation, methodological triangulation was used. Data analysis using the modified van Kaam method enabled the identification of 4 themes: preparing, partnering, mentoring, and investing. The implications of this study for positive social change include the potential for leaders of financial businesses to increase awareness of the value of talent retention efforts across organizations, thereby improving profit margins.
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42

Wu, Di. "A Novel Method to Prepare Silica Based Carbon Dioxide Capture Sorbent." University of Akron / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1215095709.

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43

Woodhead, Erik. "Imperfections and self testing in prepare-and-measure quantum key distribution." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209185.

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Quantum key distribution (QKD) protocols are intended to allow cryptographic keys to be generated and distributed in way that is provably secure based on inherent limitations, such as the no-cloning principle, imposed by quantum mechanics. This unique advantage compared with classical cryptography comes with an added difficulty: key bits in QKD protocols are encoded in analogue quantum states and their preparation is consequently subject to the usual imprecisions inevitable in any real world experiment. The negative impact of such imprecisions is illustrated for the BB84 QKD protocol. Following this, the main part of this thesis is concerned with the incorporation of such imprecisions in security proofs of the BB84 and two semi-device-independent protocols against the class of collective attacks. On a technical level, by contrast with the vast majority of security proofs developed since the turn of the century, in which recasting the protocol into an equivalent entanglement-based form features heavily in the analysis, the main results obtained here are approached directly from the prepare-and-measure perspective and in particular the connection with the no-cloning theorem and an early security proof by Fuchs et al. against the class of individual attacks is emphasised.

This thesis also summarises, as an appendix, a separate project which introduces and defines a hierarchy of polytopes intermediate between the local and no-signalling polytopes from the field of Bell nonlocality.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished

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44

Rydén, Michaéla. "Impact of different concrete types on the LCA of NCC Composite bridge." Thesis, KTH, Bro- och stålbyggnad, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-177861.

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Traditionell betong används i majoriteten av broar som byggmaterial. Om byggnadsmaterialet skulle kunna ersättas av en betong med mindre miljöpåverkan, kan stora delar av miljöpåverkan minskas. I denna avhandling, ska NCC:s samverkansbro utredas, där tre olika betongtyper ska testas i dess olika konstruktionsdelar. Samverkansbron kommer att jämföras i tre olika scenarier av byggmaterial: traditionell betong, traditionell betong innehållande 5 % slagg och injekteringsbetong. Jämförelsen kommer att utföras genom en livscykelanalys (LCA) med hjälp av programvaran GaBi 6.5. Resultatet av modelleringen i GaBi presenteras på samma sätt som i en miljövarudeklaration (EPD). I presentationen av resultatet kommer diagram och tabeller visualisera de resultat som erhållits i livscykelanalysen. Det erhållna resultatet visar att vid jämförelse av de tre scenarierna ger injekteringsbetong en mindre klimatpåverkan i majoritet av resultaten.
Traditional concrete is used in the majority of bridges as a building material. If the building material could be replaced by a concrete with less environmental impact, large parts of the environmental impact could be reduced. In this dissertation, NCC Composite Bridge is to be investigated, where three different concrete types are to be tested in its various design elements. The composite bridge will be compared in three scenarios: traditional concrete, traditional concrete with slag as part of binder and prepact concrete. The comparison will be carried out by a Life Cycle Assessment (LCA) using the software GaBi. The outcome will be in form of an Environmental Product Declaration (EPD) table. (NCC has implemented the EPD system into the company with the ambition to easier and more thorough provide a legit evaluation of the environmental impact.) In the presentation of the result, diagrams and tables visualizes the results obtained in the EPD. The result obtained has shown that comparing the three scenarios; prepact concrete provides a less environmental impact and if replacing traditional concrete with prepact, savings of the environment can be made.
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Möller, Marisa. "Oxidative status in rats exposed to social isolation rearing : behavioral pharmacology studies and relevance for schizophrenia / Marisa Moller." Thesis, North-West University, 2009. http://hdl.handle.net/10394/5091.

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PURPOSE: Psychotic (positive) symptoms are the most distinctive feature of schizophrenia, although negative symptoms such as emotional flattening, social withdrawal and cognitive disturbances are the most treatment resistant manifestation of the illness. Schizophrenia is a progressive degenerative illness that has been causally linked to environmental and neurodevelopmental factors, as well as dysfunctional redox balance. Validated animal models are useful in identifying and studying novel neurobiological targets for neuropsychiatric illnesses. Post weaning social isolation rearing (SIR) in rats has been proposed to model the neurodevelopmental aspects of schizophrenia. We validated the SIR model with respect to effects on sensorimotor gating and social interaction, deficits of which are core symptoms of schizophrenia. Following this, effects on the levels of oxidative stress were determined in the frontal cortex and striatum of rats exposed to SIR, two brain regions strongly implicated in the pathology of schizophrenia. Finally, in order to more closely relate these bio-behavioural changes to the human condition, we studied the overall effect of sub-chronic treatment with the atypical antipsychotic, clozapine, on the above described behavioural and neurochemical parameters. METHODS: Male Sprague-Dawley (SD) rats (10 rats/group) were used. In a non-treatment arm, four groups of rats were randomly separated at weaning and exposed to either 8 weeks SIR or 8 weeks social rearing. At the respective time point of 8 weeks two groups were subjected to behavioural testing of mean startle amplitude (at 120dB) and percentage prepulse inhibition (%PPI) of the acoustic startle (AS) reflex (at 72, 76, 80 and 86dB prepulse), and various social interactive and self-directed behaviours were accessed using the open field test (OFT). The remaining two groups were sacrificed at 8 weeks and brain tissue was harvested for analysis of superoxide dismutase activity, oxidized (GSSG) versus reduced (GSH) glutathione ratio, and levels of lipid peroxidation, in the frontal cortex and striatum. In the treatment arm, consisting out of eight groups of animals, four groups of SIR rats received either saline or clozapine (5mg/kg i.p.) for the last 11 days of SIR. The remaining four groups were socially reared and also received either saline or clozapine treatment as above. At 8 weeks, four groups were subjected to behavioural testing as described above and a parallel neurochemical study was performed using the same layout as above, except that after the 8 weeks, neurochemical redox analysis were done as described above. Mixed statistical modelling with repeated measures and appropriate post hoc tests were used to access the effects of SIR with and without treatment on PPI and mean startle. Social interaction in SIR and socially reared animals, with and without treatment, was analyzed using 1-way ANOVA with suitable post hoc testing. Mixed linear models with repeated measures and appropriate post hoc tests were used for analysis of the redox data in SIR and socially reared animals, with and without treatment. RESULTS: In the non-treatment arm, %PPI was significantly reduced in SIR versus socially reared rats. Deficits in various social interactive behaviours were observed in SIR versus group-housed rats, as well as increased locomotor activity and self-grooming. Superoxide dismutase activity and oxidized versus reduced glutathione ratio were significantly decreased, together with a significant increase in products of lipid peroxidation, in isolation reared versus socially reared rats. Following clozapine treatment, %PPI in isolates was significantly elevated by clozapine versus saline treatment (i.e. reversed the effect of SIR). %PPI was unaltered in socially reared animals receiving either treatment. As with the non-treatment group, social interactive behaviours were significantly impaired in isolates receiving saline, while locomotor activity and self-grooming were increased. SIR rats receiving only saline showed similar altered redox state as the non-treatment groups, while clozapine treatment effectively reversed deficits in %PPI, aberrant social behaviours and redox alterations in the SIR rats, with limited to no effects in the socially reared controls. CONCLUSION: SIR thus significantly disrupts sensorimotor gating and social behaviours in male Sprague-Dawley rats, while at the same time evokes a significant disruption of redox state in both the frontal cortex and striatum of these animals, with distinct evidence for increased oxidative stress in these brain regions. Importantly, both altered behaviour and redox state are reversed by sub-chronic clozapine treatment. SIR is therefore a useful, non-lesion and non-pharmacological neurodevelopmental animal model of schizophrenia that presents with robust face, predictive and possibly construct validity for schizophrenia.
Thesis (M.Sc. (Pharmacology))--North-West University, Potchefstroom Campus, 2010.
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46

Johnston, Craig. "Establishing a formal training program to prepare rehabilitation counselors for expert testimony." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1123516553.

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Thesis (Ph. D.)--Ohio State University, 2005.
Title from first page of PDF file. Document formatted into pages; contains xii, 171 p. Includes bibliographical references (p. 137-153). Available online via OhioLINK's ETD Center
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47

Chang, Chien-Ni. "How did the OSU M.Ed. program prepare teachers to be multiculturally competent?" Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1124218490.

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Thesis (Ph. D.)--Ohio State University, 2005.
Title from first page of PDF file. Document formatted into pages; contains xi, 227 p.; also includes graphics (some col.). Includes bibliographical references (p. 208-221). Available online via OhioLINK's ETD Center
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48

Iden, Debbie Lynne. "A novel method to prepare ligand-targeted liposomal drugs for clinical applications." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ60440.pdf.

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49

Friesen, Paul A. "The second most important decision tools to help prepare couples for marriage /." Theological Research Exchange Network (TREN), 2006. http://www.tren.com/search.cfm?p068-0598.

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50

Steinbock, Norbert. "Peak oil: the future of oil and how to prepare for it." [Denver, Colo.] : Regis University, 2009. http://165.236.235.140/lib/NSteinbock2009.pdf.

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