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Dissertations / Theses on the topic 'Presentation of peptides'

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Published: 30 November 2024
Last updated: 31 July 2025

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1

Howarth, Mark. "The presentation of suboptimal peptides by MHC Class I." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398092.

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2

Springer, Sebastian Hartmut. "The biochemistry of antigen presentation." Thesis, University of Oxford, 1996. http://ora.ox.ac.uk/objects/uuid:34d1afd2-fafc-4732-8e43-e00dcd8460d1.

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This thesis describes studies on the binding of peptides to the murine major histocompatibility complex (MHC) class I molecule H-2D<sup>b</sup> (D<sup>b</sup>). The expression of the recombinant soluble D<sup>b</sup> molecule in Chinese hamster ovary cells and its subsequent purification by nickel affinity chromatography, gel filtration, and preparative native isoelectric focusing are reported. The product is the correct molecule, homogeneous, a dimer of dimers, and free of endogenous peptide. A novel binding assay based on the enhancement of natural tryptophan fluorescence by the binding of p
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3

Winchester, Christopher Charles. "The roles of Hsp70 proteins in antigen processing and presentation." Thesis, University of Oxford, 1997. http://ora.ox.ac.uk/objects/uuid:567dff45-08ce-43b4-b011-d08afea42f76.

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The ability of members of the hsp70 family to bind to peptides in vivo and in vitro suggests that they may be involved in the processing of antigens for binding to Major Histocompatibility (MHC) class I and/or class n molecules. The aims of this thesis have been to provide evidence for the involvement of hsp70s in antigen processing and to characterise the binding of peptides by hspTOs by structural and functional studies. Firstly, the peptide-binding domains of two hsp70s, hsp70hom and PBP74, were expressed in isolation from the rest of the molecule for structure determination. Both of these
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4

Farfán, Arribas Diego José. "On the Source of Peptides for Major Histocompatibility Class I Antigen Presentation: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/589.

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Peptides generated from cellular protein degradation via the ubiquitin-proteasome pathway are presented on MHC class I as a means for the immune system to monitor polypeptides being synthesized by cells. For CD8 + T cells to prevent the spread of an incipient infection, it appears essential they should be able to sense foreign polypeptides being synthesized as soon as possible. A prompt detection of viral proteins is of great importance for the success of an adaptive immune response. Defective ribosomal products (DRiPs) have been postulated as a preferential source which would allow for a rapi
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5

Lenz, Laurel L. "Presentation of formylated bacterial peptides to cytotoxic T cells by an MHC class Ib molecule /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/8339.

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6

Thomas, Lawrence James. "Proteolytic Cleavages of Molecules Involved in Antigen Processing and Presentation: A Thesis." eScholarship@UMMS, 1989. https://escholarship.umassmed.edu/gsbs_diss/97.

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The overall goal of my thesis research was to understand better the mechanisms that control antigen processing and presentation by class II MHC molecules. Towards this goal I investigated ways in which the physical structure and post-translational modifications of the class II MHC alpha and beta chains and associated molecules might serve to regulate antigen processing and presentation. Specifically, I investigated (1) a hypothesis that Ii might aid binding of foreign antigenic peptides to the class II MHC foreign antigen binding site (desetope), and the application of this hypothesis to the p
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7

Parshotam, L. E. "Dynamic modelling of the processing of peptides for presentation on major histocompatibility complex class I proteins." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1559176/.

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Antigen presentation is broadly implicated in disease and represents an important target for prophylactic and therapeutic treatments. A better understanding of the components of this system is fundamental to our understanding of disease path- ways and to treatment design. This thesis focuses on modelling the processing of peptides by enzymes in the cytosol and in the endoplasmic reticulum (ER) in the context of major histocompatibility complex class I (MHC) antigen presentation, and expounds upon current knowledge of the mechanistic details and specificity of both the proteasome and the endopl
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8

Eccleston, Ruth Charlotte. "A mechanistic model predicting cell surface presentation of peptides by MHC class I proteins, considering peptide competition, viral intracellular kinetics and host genotype factors." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10038760/.

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Major histocompatability complex class I (MHC-I) proteins present short fragments of pathogenic or cancerous proteins (peptides) on the surface of infected cells for recognition by T lymphocytes which are stimulated upon recognition of foreign peptides. Due to the diversity of peptide sequences and the sequence-specificity of MHC-I alleles, being able to determine which peptides will be presented by which MHC-I alleles and in what proportion could be important for the development of vaccines and treatments based on the presented peptiodome. Machine learning tools, trained on experimental data,
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9

McMurtrey, Curtis Paul. "Human leukocyte antigen class I presentation and immune recognition of West Nile virus peptide epitopes." Oklahoma City : [s.n.], 2009.

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10

Schirmacher, Anastasiya. "Modification of transmembrane peptides to probe SNARE-induced membrane fusion and cross-presentation of membrane-buried epitopes." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://hdl.handle.net/21.11130/00-1735-0000-0005-1576-F.

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11

Lawand, Myriam. "Rôle des transporteurs de peptides dans la présentation antigénique par les cellules dendritiques." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T053.

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Les cellules dendritiques (DCs) sont des cellules spécialisées dans la présentation de l'antigène aux lymphocytes (CPAs), capables d'initier des réponses immunitaires adaptatives et ce sont également les acteurs majeurs de la présentation croisée des antigènes exogènes par le complexe majeur d’histocompatibilité de classe I (CMH-I). Les mécanismes moléculaires et cellulaires de la présentation croisée ont beaucoup été étudiés, mais des questions importantes restent à élucider. Notre laboratoire a précédemment montré que la pré-incubation à basse température des DCs déficientes pour TAP (transp
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12

Towne, Charles Fenton. "Analysis of the Role of Cytosolic Aminopeptidases in the Generation of MHC-Class I Presented Peptides: a Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/4.

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To detect viral infections and tumors, CD8 T lymphocytes monitor cells for the presence of antigenic peptides bound to MHC class I molecules. The majority of MHC class I-presented peptides are generated from the cleavage of cellular and viral proteins by the ubiquitin-proteasome pathway. Many of the oligopeptides produced by this process are too long to stably bind to MHC class I molecules and require further trimming for presentation. Cytosolic aminopeptidases such as leucine aminopeptidase (LAP), which is IFN-inducible, Bleomycin Hydrolase (BH), and puromycin-sensitive aminopeptidase (PSA) c
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13

Weimershaus, Mirjana Léona. "The Role of Insulin-Regulated Aminopeptidase in Cross-Presentation." Paris 5, 2011. http://www.theses.fr/2011PA05T036.

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L’aminopeptidase IRAP est localisée dans des endosomes du type de stockage dans divers types cellulaires. Dans les cellules dendritiques (CD), IRAP est impliquée dans l’élagage des ligands des molécules du CMH de classe I (CMH-I). L’absence d’IRAP provoque un défaut de la présentation d’antigènes internalisés sur le CMH-I (connue comme la “présentation croisée”). Par contre, IRAP n’est pas nécessaire dans les voies “classiques” de présentation antigéniques. Au vue de la colocalisation et interaction d’IRAP avec les CMH-I, nos observations suggèrent qu’IRAP marque un compartiment spécialisé à l
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14

Schirmacher, Anastasiya [Verfasser]. "Modification of transmembrane peptides to probe SNARE-induced membrane fusion and cross-presentation of membrane-buried epitopes / Anastasiya Schirmacher." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2021. http://d-nb.info/1228364796/34.

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15

Serra, Vincent. "Influence de l'association C3b-toxine tétanique sur la production de peptides immunogéniques." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE10046.

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La proteine c3 est impliquee dans de nombreux mecanismes de defense de l'organisme contre des elements etrangers pathogenes. C3 participe a la reponse immune naturelle : element clef du syteme du complement, elle intervient dans l'elimination des complexes immuns. Cette proteine participe egalement a la reponse immune specifique : son influence dans l'activation b a clairement ete etablie. Un role dans l'appretement et la presentation de l'ag a egalement ete suggere. Mon projet de recherche a vise a determiner l'influence de c3b sur la generation de peptides antigeniques de la tt au cours de l
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16

Hearn, Arron R. "The delivery of exogenous peptides into the class I processing and presentation pathway using the B subunit of Escherichia coli heat labile enterotoxin." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274823.

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17

MARTINEAU, PIERRE. "La proteine male d'escherichia coli k-12. Element du systeme de transport du maltose et vecteur de presentation de peptides du systeme immunitaire." Paris 7, 1991. http://www.theses.fr/1991PA077185.

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La proteine male d'e. Coli est necessaire pour le transport du maltose et pour la reponse chimiotactique vers ce sucre. Nous avons remplace par mutagenese dirigee les 8 trp et l'asn294 de la proteine par des alanines et etudie l'influence de ces mutations sur la fixation du sucre, le transport et la chimiotaxie. A partir de la structure tridimensionnelle de la proteine et des mutations decrites affectant les diverses interactions de male, nous avons propose un premier modele 3-d d'interaction de la proteine avec le complexe de la membrane interne malfgk et la proteine tar. Nous avons etudie da
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18

DELEVIL, FABIENNE. "Caracterisation d'un compartiment d'association entre les molecules du cmh de classe ii et des peptides antigeniques. Inhibition de la presentation antigenique par le lps." Aix-Marseille 2, 1999. http://www.theses.fr/1999AIX22019.

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Nous nous sommes interesses a la caracterisation d'un compartiment d'association entre les peptides antigeniques et les molecules de classe ii dans des lymphocytes b de souris. Nous avons mis en evidence par fractionnement subcellulaire l'existence d'un compartiment, le llc, apparente aux endosomes precoces et implique dans l'association de peptides issus de la proteine hel avec les molecules de classe ii neosynthetisees i-a k. Les molecules de classe ii transiteraient depuis le tgn dans les endosomes precoces ou la chaine invariante est degradee. Les molecules de classe ii seraient ensuite tr
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19

Shen, Yuelei. "MHC Class I Antigen Presentation is Regulated by the SUMO-Conjugating Enzyme UBC9: a Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/111.

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CD8 T cells recognize complexes of MHC class I and peptide on the surface of target cells. MHC class I antigen presentation is a long pathway, in which proteins are degraded by proteasomes to generating oligopeptides, which may be further trimmed by aminopeptidases in the cytosol. Peptides are transported into the ER, where they may be further trimmed by ER lumenal aminopeptidases and bind to newly-synthesized MHC class I complexes. Proteins degraded by the proteasome are generally tagged with ubiquitin by a combination of ubiquitin-conjugating enzymes and ubiquitin ligases. UBC9 is one ubiqui
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20

TOURNE, SYLVIE. "Pl les peptides associes aux molecules de classe deux du complexe majeur d'histocompatibilite : voies de presentation et fonction dans la selection positive des lymphocytes t cd4 positifs." Université Louis Pasteur (Strasbourg) (1971-2008), 1996. http://www.theses.fr/1996STR13265.

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Le systeme immunitaire a pour fonction d'eliminer tout element qu'il reconnait comme etranger a l'organisme. Les lymphocytes t cd4 reconnaissent les antigenes associes aux molecules de classe deux du complexe majeur d'histocompatibilite (cmhii). Une reponse immunitaire mediee par les cellules t cd4 depend donc d'une presentation efficace des antigenes par les molecules du cmhii et de la selection positive des lymphocytes t cd4 specifiques des peptides antigeniques. Ce travail met en evidence l'importance des complexes h2-m dans la voie classique de presentation antigenique par les molecules du
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21

Maayouf, Hasna. "Développement de plateformes de signalisation dérivées de particules pseudo-virales pour contrôler les fonctions cellulaires." Electronic Thesis or Diss., Mulhouse, 2024. http://www.theses.fr/2024MULH7387.

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Diverses stratégies de fonctionnalisation de surface visent à améliorer la biocompatibilité des matériaux pour les dispositifs implantables, notamment en ingénierie tissulaire. Par exemple, le polydiméthylsiloxane (PDMS), bien qu’utilisé dans de nombreux domaines, présente des propriétés de surface défavorables à l’adhérence cellulaire. La fonctionnalisation par des protéines de la matrice extracellulaire (MEC) ou des peptides synthétiques dérivés de celles-ci permet d’améliorer l'adhérence des cellules. Bien que ces approches offrent certaines solutions, des défis tels que le coût de producti
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22

ARNOLD, DANIELE. "Le controle genetique de la presentation de l'antigene par les molecules de classe i du complexe majeur d'histocompatibilite (cmh). Etude du transporteur de peptides (tap1/tap2) et des sous-unites proteasiques (lmp2/lmp7)." Université Louis Pasteur (Strasbourg) (1971-2008), 1993. http://www.theses.fr/1993STR13141.

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Les molecules de classe i du cmh presentent des peptides d'origine endogene a la surface de la cellule, dans le but d'assurer une surveillance par les cellules t#c#d#8#+. L'assemblage des molecules de classe i est une etape incontournable pour une migration du complexe de classe i vers la surface cellulaire. Ce mecanisme est interrompu si les peptides generes dans le cytoplasme sont incapables de traverser la membrane du reticulum endoplasmique (re), pour s'associer aux chaines de classe i naissantes. Par marche chromosomique et cartographie de deletions chez des mutants d'assemblage, nous avo
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23

Barouch, Dan H. "Peptide binding and presentation by HLA-A2." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294263.

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24

Elvin, John G. "Presentation of peptide antigens to cytotoxic T lymphocytes." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314883.

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25

Young, Lesley Lynn. "Peptide presentation by the rat class I MHC molecule RT1.Aa." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627518.

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26

MacEachern, Mary Christina. "Indirect presentation in allograft rejection and the potential for immune intervention." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246249.

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27

Tiwari, Neeraj. "Characterization of antigen processing and presentation by peptide-linked MHC class I molecules." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975866370.

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28

Taylor, Kathryn. "Structure-based refinement of peptide presentation on the surface of cowpea mosiac virus." Thesis, University of East Anglia, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389325.

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29

Haddad, Ziad. "Monocytic cell responses to Aspergillus fumigatus investigation of phagocytosis, gene expression and peptide presentation /." [S.l. : s.n.], 2006.

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30

Negroni, Maria P. "Studies in Antigen Presentation and Antigen Recognition at Different Interfaces of the Adaptive Immune System." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/996.

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Antigen presentation and recognition are key processes of the immune system necessary to initiate the adaptive immune response. Longstanding goals of these fields have been to understand the molecular mechanism of MHC II-peptide binding, the way in which dysregulation of this process can lead to disease, and determining how γδTCRs recognize their ligands. To examine some of these outstanding questions, I designed photocleavable peptides that could bind HLA-DR1 and could be used to facilitate peptide exchange. I also performed studies to understand whether peptide exchange on HLA-DR1 can be aff
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31

Sjursen, Anne Marie. "TRP1 Peptide Requires Internalization and is Partially Dependent on GILT for Efficient Presentation on MHC Class II." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/221412.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.<br>Tyrosinase-related protein 1 (TRP1) is a melanosomal integral membrane protein and melanocyte differentiation antigen that contributes to the synthesis of melanin in melanocytes. Present in both benign and malignant melanocytes, it has been implicated in the autoimmune development of vitiligo and melanoma antitumor immunity. Since a naturally occurring MHC class II-restricted TRP1 epitope contains cysteine residues, we hypothesized th
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32

Trenh, Peter. "An Examination of MHC, Peptide, and TCR Interactions." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/989.

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T cell receptors (TCR) bind to peptides from various sources on MHC (Major Histocompatibility Complex) molecules. A long-standing goal in the field is to understand the mechanisms of MHC-peptide exchange and MHC-TCR interactions. Here, I present work from three uniquely different systems that address the following: HLA-DR1 conformational stability, self-tolerant mechanisms of TCRs isolated from self-reactive TCR transgenic mice, and TCR cross-reactivity mechanisms between LCMV and VV. First, I present a crystal structure of HLA-DR1 in complex with A1L9 peptide, a peptide with two amino acid su
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33

Londono, Arcila Lida Patricia. "The use of hepatitis B cores for peptide presentation : delivery to the mouse immune system using live attenuated salmonella." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297205.

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34

Rasche, Sarah S. "Processing and Presentation of Glutamic Acid Decarboxylase 65 T cell-Inducing Epitopes: Implications in the Non-Obese Diabetic Mouse Model of Type 1 Diabetes." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1290046839.

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35

Nyambura, Lydon Wainaina. "Impact of monocyte differentiation and intracellular infection on processing and presentation of autoantigen." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19154.

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Dendritische Zellen (DCs) und Makrophagen sind spezialisierte antigenpräsentierende Zellen, die eigene und fremde Antigene prozessieren und mittels Haupthistokompatibilitätsmoleküle, humane Leukozytenantige (HLA) im Menschen, T-Zellen präsentieren, um Toleranzen zu induzieren oder T-Zell-vermittelte Immunantworten zu initiieren. Abhängig von ihrer Differenzierung haben sie spezifische Phänotypen und Funktionen undunterschiedliche Interaktionen mit Pathogenen, in dieser Arbeit durch Leishmania donovani (LD) repräsentiert, welche in Phagolysosomen der Makrophagen propagieren. Der Einfluss der D
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36

Welsby, Iain. "PARP12, a novel interferon stimulated gene potentially involved in the control of protein translation and innate immunity." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209714.

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Poly(ADP-ribose) polymerases belong to a family of proteins with 17 members in human beings. PARP1, the founding member of the family is a protein that synthesizes linear or branched polymers of ADP-ribose on itself or on target proteins. Different members of this family, that do not all possess ADP-ribosyl polymerase activity, are involved in the regulation of various cellular mechanisms. Some members of the family are particularly involved in the positive or negative control of the immune response. PARP1 is a key player in the regulation of inflammation, through its positive control of cell
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37

Pernollet, Martine. "Modification de l'antigène toxine tétanique par des radicaux libres oxygénés et par des protéines à activité peptidyl-prolyl cis-trans isomérase : influence sur sa présentation à des lymphocytes T spécifiques." Université Joseph Fourier (Grenoble ; 1971-2015), 1994. http://www.theses.fr/1994GRE10238.

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L'influence du radical libre oxygene, le radical hydroxyle (oh) et des proteines a activite peptidyl-prolyl cis-trans isomerase sur le traitement de l'antigene toxine tetanique par des cellules presentatrices d'antigenes (lymphocytes b) a ete etudiee. En ce qui concerne le radical hydroxyle, sa production par des cellules de type macrophagique a ete reproduite a l'aide d'un systeme chimique. La toxine tetanique traitee par le radical oh subit un changement de conformation, et des liaisons bityrosine intramoleculaires resistantes a la proteolyse sont formees. La toxine ainsi modifiee est plus r
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38

Aun, Jason Paul. "Analysis and quantitation of the cross presentation of tumor antigens using the HIV protein transduction domain transactivating regulatory protein (TAT) to alter presentation." 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1462704.

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39

Huczko, Eric Lee. "The binding and presentation of peptide antigens by class I major histocompatibility molecules /." 1997. http://wwwlib.umi.com/dissertations/fullcit/9738893.

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Thesis (Ph. D.)--University of Virginia, 1997.<br>Spine title: Binding of peptides by class I molecules. Includes bibliographical references (164-204). Also available online through Digital Dissertations.
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40

Fortin, Jean-Simon. "Antigen and superantigen presentation as defined by the MHCII-accessory proteins and associated-peptides." Thèse, 2013. http://hdl.handle.net/1866/12741.

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MHCII molecules expose a weave of antigens, which send survival or activation signals to T lymphocytes. The ongoing process of peptide binding to the MHC class II groove implicates three accessory molecules: the invariant chain, DM and DO. The invariant chain folds and directs the MHCII molecules to the endosomal pathway. Then, DM exchanges the CLIP peptide, which is a remnant of the degraded invariant chain, for peptides of better affinity. Expressed in highly specialized antigen presenting cells, DO competes with MHCII molecules for DM binding and favors the presentation of receptor-internal
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41

Schmidt, Andreas [Verfasser]. "Nonsense mediated decay associated pioneer round of translation as source for peptides for presentation by MHC class I / vorgelegt von Andreas Schmidt." 2009. http://d-nb.info/993748112/34.

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42

Jackson, Angela M. "Development of a mass spectrometry based method for the identification of gp96-chaperoned peptides destined for presentation in MHC class I molecules." Thesis, 2006. http://hdl.handle.net/1828/2266.

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Theileria parva is an intracellular protozoan parasite and the causative agent of the lethal livestock disease East Coast fever (ECF). Research has shown that a protective cell-mediated immune response against parasite-infected lymphocytes is capable of clearing the host of T. parva (Pearson et al. 1979), leaving the host solidly immune to reinfection. The work presented in this thesis describes my attempts to develop a method for identification of major histocompatibility complex class I-associated T. parva peptides involved in eliciting this protective cell-mediated immune response. The s
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43

de, Verteuil Danielle Angeline. "L’immunoprotéasome : producteur de peptides-CMH I et régulateur de l’expression génique." Thèse, 2014. http://hdl.handle.net/1866/10887.

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Le système ubiquitine-protéasome est le principal mécanisme par lequel les protéines intracellulaires sont dégradées. Le protéasome dit constitutif (PC) est donc essentiel à l’homéostasie mais aussi à la régulation de la majorité des processus cellulaires importants. La découverte d’un deuxième type de protéasome, appelé immunoprotéasome (IP), soulève toutefois de nouvelles questions. Pourquoi existe-t-il plus d’un type de protéasome ? L’IP a-t-il des rôles redondants ou complémentaires avec le PC ? L’IP étant présent principalement dans les cellules immunitaires ou stim
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44

Bhatnagar, Aparna. "A unique APC phenotype in the non-obese diabetic (NOD) mouse : presentation of class II MHC-associated invariant chain-derived peptides (CLIP) by I-Ag7." Phd thesis, 2001. http://hdl.handle.net/1885/147142.

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45

Côté, Marie-Hélène. "Ciblage exosomal et effet de HLA-DM sur la présentation antigénique par le complexe majeur d'histocompatibilité de classe II." Thèse, 2008. http://hdl.handle.net/1866/2799.

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Les molécules du complexe majeur d'histocompatibilité de classe II (CMH II) sont exprimées exclusivement à la surface des cellules présentatrices d'antigènes et servent à stimuler les cellules CD4+ initiant une réponse immunitaire. Le chargement peptidique sur HLA-DR se produit dans les endosomes tardifs et les lysosomes sous l'action de HLA-DM. Cette molécule de classe II non-classique enlève les fragments peptidiques de la chaîne invariante (Ii) restés associés aux molécules de classe II (CLIP) et édite leur répertoire d'antigènes présentés. En utilisant une forme mutante de HLA-DM (HLA-DMy)
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46

Granados, Diana Paola. "Effect of the unfolded protein response on MHC class I antigen presentation." Thèse, 2008. http://hdl.handle.net/1866/7632.

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47

Shen, Kuan-Yin, and 沈冠印. "Anti-tumor Effects and Antigen Presentation Mechanisms of Toll-like Receptor 2 (TLR2) agonist-conjugated peptide." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/02005787959422829416.

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博士<br>國防醫學院<br>生命科學研究所<br>102<br>Dendritic cells (DCs) can process and present extracellular antigens on MHC class I molecules to activate cytotoxic T lymphocyte (CTL) responses through an important mechanism, antigen cross-presentation. However, toll-like receptor (TLR)-mediated cross-presentation of extracellular antigens by DCs remains unclear. In this study, models of synthetic di-palmitoylated peptides (Pam2IDG and Pam2EQL) explored the mechanisms of TLR2-mediated cross-presentation. We observed that TLR2 facilitated the internalization of di-palmitoylated peptides by bone marrow-derived
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48

Tiwari, Neeraj [Verfasser]. "Characterization of antigen processing and presentation by peptide-linked MHC class I molecules / presented by Neeraj Tiwari." 2005. http://d-nb.info/975866370/34.

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49

Sever, Lital. "A Functional Study of the Major Histocompatibility Class I Antigen Presentation Pathway in Rainbow Trout (Oncorhynchus mykiss)." Thesis, 2014. http://hdl.handle.net/10012/8135.

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Major Histocompatibility Complex (MHC) class I receptors are glycoproteins which play a critical role in anti-viral immunity by displaying foreign peptides to cytotoxic T cell lymphocytes. The loading of high affinity peptides into the MHC class I receptor in mammals is coordinated by a multiple proteins that are collectively referred to as the peptide loading complex (PLC). To date, the composition of the peptide loading complex in fish is unknown and therefore the characterization of the molecules which may exist in this putative complex was pursued. This thesis includes the cloning and
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