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Dissertations / Theses on the topic 'Pressurised metered dose inhaler (pMDI)'

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Published: 4 June 2021
Last updated: 15 February 2022

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1

Davis, A. J. "A fundamental study of the flow and droplet delivery from a pressurised metered dose inhaler (pMDI)." Thesis, Loughborough University, 2008. https://dspace.lboro.ac.uk/2134/12222.

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The assessment of drug formulations delivered by the pressurised metered dose inhaler and used in the treatment of Asthma are assessed commercially using cascade impactors which are the preferred instruments for the assessment of particle size and respirable mass or fraction delivered by inhalation devices. The fundamental principle underpinning the design of cascade impactors is particle motion defined by Stokes theory. The analysis of impactor data raises a number of functional issues as calibration curves have long tails, which are not easily explained by a simplistic application of Stokes
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2

Grimble, David. "Ultra-thin film tribology of elastomeric seals in pressurised metered dose inhalers." Thesis, Loughborough University, 2009. https://dspace.lboro.ac.uk/2134/6376.

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Within pressurised Metered Dose Inhalers (pMDIs) the contact between the valve components and elastomeric seals is of major significance, representing the main contributory factor to the overall system frictional characteristics. Therefore, the seal performance is extremely important and must be optimised to meet the contradictory requirements of preventing leakage and allowing smooth actuation. The environmentally driven trend to HFA formulations as opposed to CFC based ones has deteriorated this problem due to poor lubrication conditions and it has, consequently, increased the frictional los
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3

Telford, Richard. "The Physical Chemistry of pMDI Formulations Derived from Hydrofluoroalkane Propellants. A Study of the Physical Behaviour of Poorly Soluble Active Pharmaceutical Ingredients; Bespoke Analytical Method Development Leading to Novel Formulation Approaches for Product Development." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/10098.

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Active Pharmaceutical Ingredients (APIs) are frequently prepared for delivery to the lung for local topical treatment of diseases such as Chronic Obstructive Pulmonary Disease (COPD) and asthma, or for systemic delivery. One of the most commonly used devices for this purpose is the pressurised metered dose inhaler (pMDI) whereby drugs are formulated in a volatile propellant held under pressure. The compound is aerosolised to a respirably sized dose on actuation, subsequently breathed in by the user. The use of hydrofluoroalkanes (HFAs) in pMDIs since the Montreal Protocol initiated a move away
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4

Grimes, Matthew, Paul Myrdal, and Poonam Sheth. "Cosolvent Effect on Droplet Evaporation Time, Aerodynamic Particle Size Distribution, and Differential Throat Deposition for Pressurized Metered Dose Inhalers." The University of Arizona, 2015. http://hdl.handle.net/10150/614123.

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Class of 2015 Abstract<br>Objectives: To evaluate the in vitro performance of various pressurized metered dose inhaler (pMDI) formulations by cascade impaction primarily focusing on throat deposition, fine particle fraction (FPF), and mass-median aerodynamic diameter (MMADR) measurements Methods: Ten solution pMDIs were prepared with varying cosolvent species in either low (8% w/w) or high (20% w/w) concentration. The chosen cosolvents were either alcohol (ethanol, n-propanol) or acetate (methyl-, ethyl-, and butyl acetate) in chemical nature. All formulations used HFA-134a propellant and 0.3
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5

Al, Sultan Huriah A. "In-Vitro Comparison of Aerosol Drug Delivery in Pediatrics Using Pressurized Metered Dose Inhaler, Jet Nebulizer, and Vibrating Mesh Nebulizers." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/rt_theses/15.

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Background: Aerosol therapy has been established as an efficient form of drug delivery to pediatric and adult patients with respiratory diseases; however, aerosol delivery to the pediatric population is quite challenging. While some studies compare jet nebulizer (JN), vibrating mesh nebulizer (VMN), or JN and pMDI, there is no study comparing these three devices in pediatric and young children. The aim of this study quantifies aerosol deposition using JN, VMN, and pMDI/VHC in a simulated pediatric with active and passive breathing patterns. Methods: Each aerosol generator was placed between ma
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6

Hammer, Carrie L., and Matthew D. Bertsch. "In Vitro Effect of Nonconventional Accessory Devices on Throat Deposition and Respirable Mass." The University of Arizona, 2012. http://hdl.handle.net/10150/623585.

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Class of 2012 Abstract<br>Specific Aims: To evaluate the in vitro throat deposition and respirable mass of the QVAR® pressurized metered-dose inhaler (pMDI) alone or coupled to an accessory device, such as the AeroChamber Valved Holding ChamberTM or various nonconventional accessory devices. Methods: The performance of the AeroChamber and nonconventional accessory devices, including a toilet paper roll, paper towel roll, rolled paper, plastic bottle spacer, plastic bottle reverse-flow holding chamber, and nebulizer reservoir tubing, were compared to no accessory device. Throat deposition and
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7

Alalwan, Mahmood A. "In Vitro Evaluation oF Aerosol Drug Delivery With And Without High Flow Nasal Cannula Using Pressurized Metered Dose Inhaler And Jet Nebulizer in Pediatrics." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/rt_theses/14.

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Background: HFNC system is a novel device used with aerosol therapy and seems to be rapidly accepted. Although there are some studies conducted on HFNC and vibrating mesh nebulizer, the effect of HFNC on aerosol delivery using jet nebulizer or pressurized metered-dose inhaler (pMDI) has not been reported. In an effort to examine the effect of HFNC on aerosol deposition, this study was conducted to quantify aerosol drug delivery with or without a HFNC using either pMDI or jet nebulizer. Methodology: The SAINT model, attached to an absolute filter (Respirgard II, Vital Signs Colorado Inc., Engle
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8

Hammer, Carrie L., Matthew D. Bertsch, Paul B. Myrdal, and Poonam Sheth. "In Vitro Effect of Nonconventional Accessory Devices on Throat Deposition and Respirable Mass." The University of Arizona, 2012. http://hdl.handle.net/10150/614433.

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Class of 2012 Abstract<br>Specific Aims: To evaluate the in vitro throat deposition and respirable mass of the QVAR® pressurized metered-dose inhaler (pMDI) alone or coupled to an accessory device, such as the AeroChamber Valved Holding ChamberTM or various nonconventional accessory devices. Methods: The performance of the AeroChamber and nonconventional accessory devices, including a toilet paper roll, paper towel roll, rolled paper, plastic bottle spacer, plastic bottle reverse-flow holding chamber, and nebulizer reservoir tubing, were compared to no accessory device. Throat deposition and
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9

Sheth, Poonam. "Theoretical and Experimental Behavior of Suspension Pressurized Metered Dose Inhalers." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/325231.

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Pressurized metered dose inhalers (pMDIs) are widely utilized to manage diseases of the lungs, such as asthma and chronic obstructive pulmonary disease. They can be formulated such that the drug and/or nonvolatile excipients are dissolved or dispersed in the formulation, rendering a solution or suspension formulation, respectively. While the formulation process for solution pMDIs is well defined, the formulation process of pMDIs with any type of suspended entity can be lengthy and empirical. The use of suspended drug or the addition of a second drug or excipient in a suspension pMDI formulatio
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10

Dunbar, C. A. "An experimental and theoretical investigation of the spray issued from a pressurised metered-dose inhaler." Thesis, University of Manchester, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.587518.

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This research was concerned with the experimental and theoretical investigation of the spray issued from a pressurised metered-dose inhaler (pMDI) and has been motivated by the urgent need to find suitable replacements to the environmentally destructive Cf'Csbased propellants currently used and to extend the working knowledge of the device. The majority of the experimental work was conducted using phase-Doppler anemometry (PDA), a single particle light scattering technique which provides the simultaneous measurement of drop size, velocity and concentration, yielding the most detailed temporal
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11

Cocks, Elizabeth Ann. "The delivery of porous poly(D1-lactide-Co-glycolide) microspheres via pressurised metered dose inhaler suspensions." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404334.

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12

Kotian, Reshma. "Electrical Behavior of Non-Aqueous Formulations: Role of Electrostatic Interactions in Pressurized Metered Dose Inhalers (pMDIs)." Unavailable until 8/19/2013, 2008. http://hdl.handle.net/10156/2280.

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13

Shaik, Abdul Qaiyum. "Numerical modeling of two-phase flashing propellant flow inside the twin-orifice system of pressurized metered dose inhalers." Thesis, Loughborough University, 2010. https://dspace.lboro.ac.uk/2134/6161.

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Pressurized metered-dose inhalers (pMDIs) are the most widely-prescribed inhaler devices for therapeutic aerosol delivery in the treatment of lung diseases. In spite of its undoubted therapeutic and commercial success, the propellant flow mechanics and aerosol formation by the pMDIs is poorly understood. The process involves a complex transient cavitating turbulent fluid that flashes into rapidly evaporating droplets, but details remain elusive, partly due to the difficulty of performing experiments at the small length scales and short time scales. The objective of the current work is the deve
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14

Almeziny, Mohammed A. N. "Performance of two different types of inhalers. Influence of flow and spacer on emitted dose and aerodynamic characterisation." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4299.

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This thesis is based around examination of three mainstream inhaled drugs Formoterol, Budesonide and Beclomethasone for treatment of asthma and COPD. The areas investigated are these which have been raised in reports and studies, where there are concern, for drug use and assessment of their use. In reporting this work the literature study sets out a brief summary of the background and anatomy and physiology of the respiratory system and then discuses the mechanism of drug deposition in the lung, as well as the methods of studying deposition and pulmonary delivery devices. This section
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15

Almeziny, Mohammed Abdullah N. "Performance of two different types of inhalers : influence of flow and spacer on emitted dose and aerodynamic characterisation." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4299.

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This thesis is based around examination of three mainstream inhaled drugs Formoterol, Budesonide and Beclomethasone for treatment of asthma and COPD. The areas investigated are these which have been raised in reports and studies, where there are concern, for drug use and assessment of their use. In reporting this work the literature study sets out a brief summary of the background and anatomy and physiology of the respiratory system and then discuses the mechanism of drug deposition in the lung, as well as the methods of studying deposition and pulmonary delivery devices. This section includes
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16

Oliveira, Ricardo Falcão. "Study and development of a holdingchamber for inhalation." Doctoral thesis, 2016. http://hdl.handle.net/1822/43127.

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Tese de Doutoramento em Engenharia Mecânica<br>Asthma is a respiratory disease that causes chronic airway inflammation. Affecting more than 300 million individuals worldwide, it is a growing public health hazard. Inhalation therapy is the preferred strategy for medication delivery. This therapy is executed through specific delivery devices, whereas the pressurized Metered-Dose Inhaler (pMDI) is one of the most preferred. However, the pMDI efficiency is highly dependent on a correctly executed inhalation procedure. For children under 5 years old (or elderly individuals), it is advisable to
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