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Journal articles on the topic 'Pretransplant testing'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Tiwari, AseemK, and Rajni Chauhan. "Pretransplant compatibility testing: Algorithmic approach!" Global Journal of Transfusion Medicine 3, no. 1 (2018): 39. http://dx.doi.org/10.4103/gjtm.gjtm_17_18.

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2

Copelan., Edward A. "Predicitve Value of Pretransplant Testing." Blood 104, no. 11 (2004): 1144. http://dx.doi.org/10.1182/blood.v104.11.1144.1144.

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Abstract Routine evaluation prior to stem cell transplantation generally includes assessment of left ventricular ejection fraction (EF), pulmonary function, renal function, liver function, and functional status. Patients in whom compromised organ function is detected, are often deemed ineligible for myeloablative transplantation. However, the predictive value of specific pretransplant tests is not well documented, and has not been critically analyzed in patients receiving busulfan-based preparative regimens. We analyzed the prognostic value of the pretransplant evaluation performed in 1035 con

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Stubenitsky, Bart M., Maurits H. Booster, Lauren Brasile, Dorian Araneda, Carl E. Haisch, and Gauke Kootstra. "PRETRANSPLANT PROGNOSTIC TESTING OF DAMAGED KIDNEYS DURING EMS PERFUSION." ASAIO Journal 46, no. 2 (2000): 210. http://dx.doi.org/10.1097/00002480-200003000-00238.

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4

&NA;. "EVALUATION OF HLA ANTIBODY TESTING IN PREDICTING PRETRANSPLANT CROSSMATCH RESULTS." Transplantation 82, Suppl 2 (2006): 774. http://dx.doi.org/10.1097/00007890-200607152-02130.

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5

Turton-Weeks, Susan, Gary W. Barone, Bill J. Gurley, et al. "Pretransplant Evaluation of a Patient with Acute Intermittent Porphyria." Progress in Transplantation 11, no. 3 (2001): 214–16. http://dx.doi.org/10.1177/152692480101100311.

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The pretransplant evaluation of a patient with a rare diagnosis requires knowledge of the pathophysiology and the transplant literature. A 55-year-old man presented with hypertensive kidney failure and the clinical diagnosis of acute intermittent porphyria. Complications of acute intermittent porphyria, which is a defect of heme production, are due to the accumulation of heme intermediates often precipitated by medications. Based on animal data, cyclosporine is considered unsafe in patients with acute intermittent porphyria. As part of the pretransplant evaluation, the patient received separat

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Okeke, R., J. Lok, R. Wells, et al. "Catastrophic Antiphospholipid Syndrome after Orthotopic Liver Transplant." Case Reports in Transplantation 2022 (May 5, 2022): 1–8. http://dx.doi.org/10.1155/2022/6209300.

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Background. Catastrophic antiphospholipid syndrome (CAPS) is an autoimmune thrombogenic disorder of small and large vessels caused by autoantibodies against phospholipids and phospholipid-binding proteins. This severe form of antiphospholipid syndrome (APS) presents clinically with simultaneous life-threatening multiorgan thrombosis and the presence of two or more persistent antiphospholipid antibodies (APL) confirmed on testing 12 weeks apart. Case Presentation. We describe a case report of a 66-year-old woman with detected antinuclear antibodies (ANA) pretransplant diagnosed with CAPS follow

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7

Tan, Susanna K., Chunhong Huang, Malaya K. Sahoo, et al. "Impact of Pretransplant Donor BK Viruria in Kidney Transplant Recipients." Journal of Infectious Diseases 220, no. 3 (2019): 370–76. http://dx.doi.org/10.1093/infdis/jiz114.

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Abstract Background BK virus (BKV) is a significant cause of nephropathy in kidney transplantation. The goal of this study was to characterize the course and source of BKV in kidney transplant recipients. Methods We prospectively collected pretransplant plasma and urine samples from living and deceased kidney donors and performed BKV polymerase chain reaction (PCR) and immunoglobulin G (IgG) testing on pretransplant and serially collected posttransplant samples in kidney transplant recipients. Results Among deceased donors, 8.1% (17/208) had detectable BKV DNA in urine prior to organ procureme

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Feldman, Amy G., Susan Moore, Sheana Bull, et al. "A Smartphone App to Increase Immunizations in the Pediatric Solid Organ Transplant Population: Development and Initial Usability Study." JMIR Formative Research 6, no. 1 (2022): e32273. http://dx.doi.org/10.2196/32273.

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Background Vaccine-preventable infections result in significant morbidity, mortality, and costs in pediatric transplant recipients. However, at the time of transplant, less than 20% of children are up-to-date for age-appropriate immunizations that could prevent these diseases. Smartphone apps have the potential to increase immunization rates through their ability to provide vaccine education, send vaccine reminders, and facilitate communication between parents and a multidisciplinary medical group. Objective The aim of this study was to describe the development of a smartphone app, Immunize Pe

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Posner, Shai, Raymond T. Finn, Rahul A. Shimpi, et al. "Esophageal contractility increases and gastroesophageal reflux does not worsen after lung transplantation." Diseases of the Esophagus 32, no. 10 (2019): 1–8. http://dx.doi.org/10.1093/dote/doz039.

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SUMMARY Gastroesophageal reflux and esophageal dysmotility are common in patients with advanced lung disease and are associated with allograft dysfunction after lung transplantation. The effect of transplantation on reflux and esophageal motility is unclear. The aim of this study was to describe the changes in esophageal function occurring after lung transplantation. A retrospective cohort study was performed on lung transplant candidates evaluated at a tertiary care center between 2015 and 2016. A total of 76 patients who underwent lung transplantation had high-resolution manometry and ambula

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10

Murad, Haris, Erik Dubberke, Munis Mattu, Bijal Parikh, Jason Wellen, and Tarek Alhamad. "Repeat SARS‐CoV‐2 testing after recovery. Is a pretransplant PCR necessary?" American Journal of Transplantation 21, no. 9 (2021): 3206–7. http://dx.doi.org/10.1111/ajt.16506.

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11

Aziz, Feroz, AseemK Tiwari, HimanshuV Patel, and Rajni Chauhan. "Pretransplant histocompatibility testing algorithm: Laboratory and clinical approach in the Indian context." Indian Journal of Transplantation 15, no. 1 (2021): 4. http://dx.doi.org/10.4103/ijot.ijot_82_20.

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12

Tiwari, AseemK, Geet Aggarwal, and Rajni Chauhan. "An algorithm of pretransplant compatibility testing for deceased-donor kidney transplant program." Global Journal of Transfusion Medicine 5, no. 2 (2020): 230. http://dx.doi.org/10.4103/gjtm.gjtm_98_20.

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13

Potena, Luciano, Andrea Bontadini, Sandra Iannelli, et al. "Occurrence of Fatal and Nonfatal Adverse Outcomes after Heart Transplantation in Patients with Pretransplant Noncytotoxic HLA Antibodies." Journal of Transplantation 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/519680.

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HLA antibodies (HLA ab) in transplant candidates have been associated with poor outcome. However, clinical relevance of noncytotoxic antibodies after heart transplant (HT) is controversial. By using a Luminex-based HLA screening, we retested pretransplant sera from HT recipients testing negative for cytotoxic HLA ab and for prospective crossmatch. Out of the 173 consecutive patients assayed (52±13y; 16% females; 47% ischemic etiology), 32 (18%) showed pretransplant HLA ab, and 12 (7%) tested positive against both class I and class II HLA. Recipients with any HLA ab had poorer survival than tho

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14

Gerull, Sabine, Andreas S. Buser, Christoph Bucher, et al. "Evaluation Of The Pre-Transplantation Workup Before Allogeneic Transplantation and Reasons For Delaying Or Cancelling Transplant." Blood 122, no. 21 (2013): 5456. http://dx.doi.org/10.1182/blood.v122.21.5456.5456.

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Abstract Introduction Before allogeneic transplantation, an extensive workup is generally performed to evaluate disease status, prior organ damage and ability to tolerate intensive treatment. Due to lack of specific guidelines, the extent of the workup varies substantially among centers. In an attempt to understand the significance of the different components of pretransplant workup, we evaluated 150 consecutive transplants at our center. Furthermore, we analyzed reasons for delaying or cancelling transplants after admission for workup. Patients and methods Between May 2010 and October 2012, 1

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15

Marbun, Maruhum Bonar H., Endang Susalit, Utami Susilowati, and Tantika Andina. "Long-term outcomes and prognostic factors in kidney transplant recipients in Jakarta, Indonesia: a cohort study." BMJ Open 12, no. 5 (2022): e059631. http://dx.doi.org/10.1136/bmjopen-2021-059631.

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ObjectivesTo determine the long-term survival rates and prognostic factors in kidney transplant (KT) recipients in Jakarta, Indonesia.DesignRetrospective cohort study.SettingA KT centre in Jakarta.ParticipantsWe enrolled 754 consecutive adult recipients who underwent KT between 2010 and 2020.Main outcome measuresRates of 10-year patient, all-cause and death-censored graft survival and their prognostic factors in KT recipients.ResultsThe 10-year patient survival, all-cause survival and death-censored graft survival rates of KT recipients were 74%, 68% and 81%, respectively. The prognostic facto

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16

Blumenfeld, Jon D. "Pretransplant Genetic Testing of Live Kidney Donors at Risk for Autosomal Dominant Polycystic Kidney Disease." Transplantation 87, no. 1 (2009): 6–7. http://dx.doi.org/10.1097/tp.0b013e318191965d.

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17

Focosi, Daniele. "Advances in Pretransplant Donor-Specific Antibody Testing in Solid Organ Transplantation: From Bench to Bedside." International Reviews of Immunology 35, no. 4 (2016): 351–68. http://dx.doi.org/10.3109/08830185.2016.1154051.

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18

McBride, Ali, Karen Fancher, Jongphil Kim, et al. "Pretransplant Factors That Influence Intravenous Busulfan Kinetics in Adult Patients." Blood 114, no. 22 (2009): 3350. http://dx.doi.org/10.1182/blood.v114.22.3350.3350.

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Abstract Abstract 3350 Poster Board III-238 We performed a retrospective review of intravenous busulfan (Bu) pharmacokinetic (PK) parameters and pretransplant characteristics on patient receiving Bu and fludarabine (40mg/m2/day x 4) (BuFlu) prior to allogeneic hematopoietic cell transplant (HCT) in order to determine the predictive value of pretransplant characteristics on Bu area under the concentration time curve (AUC). Included in this analysis are 265 pts transplanted between 7/04 and 12/08 who received 130 or 145mg/m2/day for 2 doses then had doses 3 and 4 adjusted based on first dose PK

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19

Ali, Ala, Aroub AL-Kaisi, and Iqbal Ali. "Clinical Relevance of Pretransplant Testing for Anti-Human Leukocyte Antigen Antibodies in Iraqi Renal Transplant Patients." Experimental and Clinical Transplantation 17, Suppl 1 (2019): 164–68. http://dx.doi.org/10.6002/ect.mesot2018.p40.

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20

Ali, Abdalla M., Ian W. Gibson, Patricia Birk, and Tom D. Blydt-Hansen. "Pretransplant serologic testing to identify the risk of polyoma BK viremia in pediatric kidney transplant recipients." Pediatric Transplantation 15, no. 8 (2011): 827–34. http://dx.doi.org/10.1111/j.1399-3046.2011.01583.x.

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21

Curry, Scott, Danielle Gill, Aisha Vanderhorst, Kate Kiley, and Carolina Cassandra Salgado. "Prevalence and Incidence of Clostridioides difficile Colonization Among a Cohort of Transplant Patients." Infection Control & Hospital Epidemiology 41, S1 (2020): s357. http://dx.doi.org/10.1017/ice.2020.978.

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Background: Allogeneic bone marrow transplant (BMT) as well as liver, heart, and lung transplant patients have high reported incidence rates of Clostridioides difficile infection (CDI). The prevalence and incidence of asymptomatic colonization with Clostridioides difficile (ACCD) in this group is not known. Methods: ACCD was defined as the presence of C. difficile on screening cultures without positive clinical testing for CDI ±1 week from the date of sampling. Patients undergoing BMT as well as liver, heart, and lung transplants at MUSC between October 2017 and October 2019 were cultured for

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22

Anasetti, C., and J. A. Hansen. "Anti-lymphocyte antibody crossmatch by flow microfluorimetry (FMF): Pretransplant testing of patient's serum and HLA nonidentical donor cells." Human Immunology 23, no. 2 (1988): 76. http://dx.doi.org/10.1016/0198-8859(88)90093-6.

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23

Lecadieu, Arnaud, Laura Teysseyre, Kevin Larsen, et al. "Case Report: Transmission of Dengue Virus from a Deceased Donor to a Kidney Transplant Recipient Previously Infected by Dengue Virus." American Journal of Tropical Medicine and Hygiene 104, no. 6 (2021): 2199–201. http://dx.doi.org/10.4269/ajtmh.21-0137.

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Abstract.Since 2018, a dengue epidemic has been ongoing in the French overseas department of Reunion Island, in the Indian Ocean, with more than 25,000 serologically confirmed cases. Currently, three dengue serotypes have been identified in Réunion Island (DENV-1, DENV-2, and DENV-3) progressing in the form of epidemic outbreaks. This arbovirus is mainly transmitted by mosquitoes of the genus Aedes and may be responsible for serious clinical forms. To date, very few cases of kidney transplant–related dengue virus infection have been described. Here we report the first case of severe dengue vir

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Hyson, Peter, Lilian Vargas Barahona, Laura C. Pedraza-Arévalo, et al. "Experiences with Diagnosis and Treatment of Chagas Disease at a United States Teaching Hospital—Clinical Features of Patients with Positive Screening Serologic Testing." Tropical Medicine and Infectious Disease 6, no. 2 (2021): 93. http://dx.doi.org/10.3390/tropicalmed6020093.

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Chagas disease (CD) is the third most common parasitic infection globally and can cause cardiac and gastrointestinal complications. Around 300,000 carriers of CD live in the U.S., with about 3000 of those in Colorado. We described our experience in diagnosing CD at a Colorado teaching hospital to revise screening eligibility criteria. From 2006 to 2020, we reviewed Trypanosoma cruzi (TC) IgG serology results for 1156 patients in our institution. We identified 23 patients (1.99%) who had a positive test. A total of 14/23 (60%) of positive serologies never had confirmatory testing, and 7 of them

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Jesse, Michelle T., Erin Clifton, Dean Y. Kim, et al. "Prerenal Transplant Education and Evaluation Positively Impacts Outcomes." Progress in Transplantation 32, no. 1 (2021): 4–10. http://dx.doi.org/10.1177/15269248211064888.

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Introduction: An outstanding question in kidney transplantation is how to prepare candidates and their social supports for optimal posttransplant outcomes. Project Aims: This program evaluation assessed whether a pretransplant quality improvement clinic improved clinical outcomes in the year posttransplant compared to recipients receiving standard of care. Design: The Countdown to Transplant Clinic was implemented with kidney transplant candidates expected to receive a transplant within the next few months. The clinic included an enhanced education session on posttransplant lifestyle managemen

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Wettstein, Dániel, and Dorottya Szentiványi. "Challenges of the modern antibody diagnostics in kidney transplantation." Orvosi Hetilap 155, no. 46 (2014): 1820–30. http://dx.doi.org/10.1556/oh.2014.30030.

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Overcoming antibody mediated rejection is of increasing interest in the field of transplantation immunology. The recipient’s antibodies against the graft human leukocyte antigens are responsible for antibody mediated graft injury. Introduction of the solid phase immunoassay technology radically changed the monitoring practice of antibodies against human leukocyte antigens, and this has consequences both for pretransplant and posttransplant phases, though our knowledge about the clinical interpretation of the detected antibodies is limited. This integrating review reports recommendations and al

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Lorenz, Elizabeth C., Fernando G. Cosio, Shari L. Bernard, et al. "The Relationship Between Frailty and Decreased Physical Performance With Death on the Kidney Transplant Waiting List." Progress in Transplantation 29, no. 2 (2019): 108–14. http://dx.doi.org/10.1177/1526924819835803.

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Introduction: Frailty and decreased physical performance are associated with poor outcomes after kidney transplant. Less is known about their relationship with pretransplant outcomes. The aim of this study was to characterize associations between frailty and physical performance with death on the kidney transplant waiting list. Design: Since December 2014, high-risk kidney transplant candidates at our center (age > 59, diabetic and/or history of >3 years dialysis) have undergone frailty and physical performance testing using Fried Criteria and the Short Physical Performance Battery. Resu

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Dillon, Laura W., Gege Gui, Brent R. Logan, et al. "Impact of Conditioning Intensity and Genomics on Relapse After Allogeneic Transplantation for Patients With Myelodysplastic Syndrome." JCO Precision Oncology, no. 5 (January 2021): 265–74. http://dx.doi.org/10.1200/po.20.00355.

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PURPOSE Patients with myelodysplastic syndrome (MDS) are at risk of relapse after allogeneic hematopoietic cell transplantation. The utility of ultra-deep genomic testing to predict and the impact of conditioning intensity to prevent MDS relapse are unknown. METHODS Targeted error-corrected DNA sequencing was performed on preconditioning blood samples from patients with MDS (n = 48) from the Blood and Marrow Transplant Clinical Trials Network 0901 phase III randomized clinical trial, which compared outcomes by allogeneic hematopoietic cell transplantation conditioning intensity in adult patien

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Lan, James H., Matthew Kadatz, Doris T. Chang, Jagbir Gill, Howard M. Gebel, and John S. Gill. "Pretransplant Calculated Panel Reactive Antibody in the Absence of Donor-Specific Antibody and Kidney Allograft Survival." Clinical Journal of the American Society of Nephrology 16, no. 2 (2021): 275–83. http://dx.doi.org/10.2215/cjn.13640820.

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Background and objectivesPanel reactive antibody informs the likelihood of finding an HLA-compatible donor for transplant candidates, but has historically been associated with acute rejection and allograft survival because testing methods could not exclude the presence of concomitant donor-specific antibodies. Despite new methods to exclude donor-specific antibodies, panel reactive antibody continues to be used to determine the choice of induction and maintenance immunosuppression. The study objective was to determine the clinical relevance of panel reactive antibody in the absence of donor-sp

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Dillon, Laura W., Gege Gui, Kristin M. Page, et al. "DNA Sequencing to Detect Residual Disease in Adults With Acute Myeloid Leukemia Prior to Hematopoietic Cell Transplant." JAMA 329, no. 9 (2023): 745. http://dx.doi.org/10.1001/jama.2023.1363.

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ImportancePreventing relapse for adults with acute myeloid leukemia (AML) in first remission is the most common indication for allogeneic hematopoietic cell transplant. The presence of AML measurable residual disease (MRD) has been associated with higher relapse rates, but testing is not standardized.ObjectiveTo determine whether DNA sequencing to identify residual variants in the blood of adults with AML in first remission before allogeneic hematopoietic cell transplant identifies patients at increased risk of relapse and poorer overall survival compared with those without these DNA variants.

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Quan Le, Robert, Natasha A. Jain, Xin Tian, et al. "Comorbidity Measures In Ex Vivo T Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation (HCT)." Blood 122, no. 21 (2013): 2124. http://dx.doi.org/10.1182/blood.v122.21.2124.2124.

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Abstract Clinical comorbidity measures enhance the estimates of HCT tolerance and outcomes, thereby aiding therapeutic decisions. Ex vivo T cell depletion (TCD) of the graft reduces the risk of graft-versus-host disease and improves the tolerability of allogeneic transplantation in patients with impaired pretransplant performance. However, prediction tools such as the hematopoietic cell transplantation-specific comorbidity index (HCT-CI), have only been validated in conventional T-replete HCT. To improve outcome prediction in TCD transplants we therefore evaluated published comorbidity measure

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Belli, Luca Saverio, Christophe Duvoux, Paolo Angelo Cortesi, et al. "COVID-19 in liver transplant candidates: pretransplant and post-transplant outcomes - an ELITA/ELTR multicentre cohort study." Gut 70, no. 10 (2021): 1914–24. http://dx.doi.org/10.1136/gutjnl-2021-324879.

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ObjectiveExplore the impact of COVID-19 on patients on the waiting list for liver transplantation (LT) and on their post-LT course.DesignData from consecutive adult LT candidates with COVID-19 were collected across Europe in a dedicated registry and were analysed.ResultsFrom 21 February to 20 November 2020, 136 adult cases with laboratory-confirmed SARS-CoV-2 infection from 33 centres in 11 European countries were collected, with 113 having COVID-19. Thirty-seven (37/113, 32.7%) patients died after a median of 18 (10–30) days, with respiratory failure being the major cause (33/37, 89.2%). The

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Radujkovic, Aleksandar, Thomas Luft, Peter Dreger, et al. "In vitro testing of drug combinations employing nilotinib and alkylating agents with regard to pretransplant conditioning treatment of advanced-phase chronic myeloid leukemia." Cancer Chemotherapy and Pharmacology 74, no. 2 (2014): 427–32. http://dx.doi.org/10.1007/s00280-014-2533-6.

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Okolo, Onyemaechi N., Emmanuel Katsanis, Seongseok Yun, Candace Y. Reveles, and Faiz Anwer. "Allogeneic Transplant in ELANE and MEFV Mutation Positive Severe Cyclic Neutropenia: Review of Prognostic Factors for Secondary Severe Events." Case Reports in Hematology 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/5375793.

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Objective and Importance.Cyclic neutropenia (CyN) is a rare autosomal dominant inherited disorder due to the mutation ELANE primarily affecting bone marrow stem cells and is characterized by recurrent neutropenia every 2 to 4 weeks. Symptoms vary from benign to severe, including death. Postulations on the cause of wide spectrum in symptom presentation include the possibility of other genetic mutations, such as MEFV. Recommended treatment for CyN is G-CSF to keep ANC higher to minimize risk of infection.Case.A 25-year-old male diagnosed with CyN, on G-CSF but worsening quality of life. Pretrans

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Pouch, Stephanie M., Shalika B. Katugaha, Wun-Ju Shieh, et al. "Transmission of Eastern Equine Encephalitis Virus From an Organ Donor to 3 Transplant Recipients." Clinical Infectious Diseases 69, no. 3 (2018): 450–58. http://dx.doi.org/10.1093/cid/ciy923.

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Abstract Background In fall 2017, 3 solid organ transplant (SOT) recipients from a common donor developed encephalitis within 1 week of transplantation, prompting suspicion of transplant-transmitted infection. Eastern equine encephalitis virus (EEEV) infection was identified during testing of endomyocardial tissue from the heart recipient. Methods We reviewed medical records of the organ donor and transplant recipients and tested serum, whole blood, cerebrospinal fluid, and tissue from the donor and recipients for evidence of EEEV infection by multiple assays. We investigated blood transfusion

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Mistry, Bhargav M., Bahar Bastani, Harvey Solomon, et al. "Prognostic value of dipyridamole thallium‐201 screening to minimize perioperative cardiac complications in diabetics undergoing kidney or kidney‐pancreas transplantation." Clinical Transplantation 12, no. 2 (1998): 130–35. http://dx.doi.org/10.1111/j.1399-0012.1998.tb01081.x.

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To minimize perloperative cardiac events, we utilize a screening protocol consisting of intravenous dipyridamole thallium‐201 myocardial imaging (DPT), with the selective use of coronary angiography based on the presence of reversible defect(s) on DPT test. A retrospective study was performed to determine the prognostic value of this protocol and to identify any clinical parameters predictive of an abnormal DPT test. To accomplish this, a detailed chart analysis of 176 consecutive kidney (n = 89) and kidney‐pancreas (n = 87) transplant. recipients who had undergone pretransplant DPT testing wa

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Speake, Cate, Alyssa Ylescupidez, Daniel Neiman, et al. "Circulating Unmethylated Insulin DNA As a Biomarker of Human Beta Cell Death: A Multi-laboratory Assay Comparison." Journal of Clinical Endocrinology & Metabolism 105, no. 3 (2020): 781–91. http://dx.doi.org/10.1210/clinem/dgaa008.

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Abstract Context There is an unmet need for biomarkers of pancreatic beta-cell death to improve early diagnosis of type 1 diabetes, enroll subjects into clinical trials, and assess treatment response. To address this need, several groups developed assays measuring insulin deoxyribonucleic acid (DNA) with unmethylated CpG sites in cell-free DNA. Unmethylated insulin DNA should be derived predominantly from beta-cells and indicate ongoing beta-cell death. Objective To assess the performance of three unmethylated insulin DNA assays. Design and Participants Plasma or serum samples from 13 subjects

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Normann, Amber J., Clifton C. Mo, Rebekah L. Wilson, et al. "Prehabilitation Exercise Training to Target Improved Muscle Strength in Pretransplant Patients Diagnosed With Multiple Myeloma: Protocol for a Pilot Randomized Controlled Trial." JMIR Research Protocols 13 (December 19, 2024): e64905. https://doi.org/10.2196/64905.

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Background Muscle mass and strength are severely compromised in patients diagnosed with multiple myeloma, such that the risk of poor overall survival increases as the prevalence of low muscle mass, also known as sarcopenia, increases. Additionally, at the time of autologous stem cell transplant (ASCT), 51% of patients experience low muscle mass and strength, which can prolong hospitalization and lead to increased risk of obesity, insulin resistance, lowered physical function, and poor quality of life. Objective The PROTECT (Prehabilitation Exercise Training in Multiple Myeloma Patients Undergo

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Chowdhry, Mohit, R. N. Makroo, Mandhata Singh, Manoj Kumar, Yogita Thakur, and Vandana Sharma. "Role of Anti-MICA Antibodies in Graft Survival of Renal Transplant Recipients of India." Journal of Immunology Research 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/3434050.

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Introduction. The MIC (MHC class I chain-related) genes are a group of nonclassical MHC genes, located in the MHC class 1 region of chromosome 6. The aim of the present study was to find the prevalence of MHC class 1 chain-related (MICA) alloantibodies in patients undergoing live-related donor renal transplantation and its role in short-term graft survival. The role of blood transfusion in the formation of these antibodies was also studied. Materials and Methods. Pretransplant samples of patients undergoing renal allograft transplantation were tested for anti-MICA antibodies. Association of va

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El Hussein, Siba, Andrew G. Evans, John M. Fitzsimmons та ін. "Clonal cytopenia of undetermined significance (CCUS)-associated reversion of donor-derived, transient αβ T-cell large granular clonal lymphocytosis, emerging post-transplant in a patient with a history of γδ T-cell large granular lymphocytic leukemia". Molecular Case Studies 9, № 2 (2023): a006241. http://dx.doi.org/10.1101/mcs.a006241.

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Autologous and allogeneic hematopoietic stem cell transplantation (HSCT) has revolutionized the therapy of hematolymphoid malignancies. Yet, how to best detect or predict the emergence of HSCT-related complications remain unresolved. Here, we describe a case of donor-derived, transient Alpha Beta (αβ) T-cell large granular clonal lymphocytosis and cytopenia that emerged post-HSCT in a patient with a history of gamma delta (γδ) T-cell large granular lymphocytic leukemia (T-LGLL). Clonal unrelatedness of post-transplant T-LGL lymphocytosis to the patient's pretransplant T-LGLL was first identifi

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Eurich, Dennis, Stephan Schlickeiser, Ramin Raul Ossami Saidy, et al. "How to Estimate the Probability of Tolerance Long-Term in Liver Transplant Recipients." Journal of Clinical Medicine 12, no. 20 (2023): 6546. http://dx.doi.org/10.3390/jcm12206546.

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Background: Operational tolerance as the ability to accept the liver transplant without pharmacological immunosuppression is a common phenomenon in the long-term course. However, it is currently underutilized due to a lack of simple diagnostic support and fear of rejection despite its recognized benefits. In the present work, we present a simple score based on clinical parameters to estimate the probability of tolerance. Patients and methods: In order to estimate the probability of tolerance, clinical parameters from 82 patients after LT who underwent weaning from the IS for various reasons at

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Diana, Jean-Sebastien, Despina Moshous, Martin Castelle, et al. "Gene Therapy for Artemis-SCID and Artemis-Leaky-SCID Patients: Preliminary Results of the French Artegene Phase I/II Clinical Trial." Blood 144, Supplement 1 (2024): 2201. https://doi.org/10.1182/blood-2024-208350.

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Introduction: Genetic deficiency of the endonuclease DCLRE1C/Artemis, a key factor for the Non-Homologous End-Joining (NHEJ) mechanism, causes Severe Combined Immunodeficiency (SCID) or leaky-SCID characterized by a lack of T and B-cells associated with hypersensitivity to ionizing radiations. Allogeneic Hematopoietic Stem and progenitor Cells (HSPCs) transplantation is the gold standard for treating Artemis deficiency. However, graft-versus-host disease and graft rejection, which can lead to post-transplant complications and mortality, are increased in case of HLA incompatibility between the

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Ashokkumar, Chethan, Mylarappa Ningappa, Vikram Raghu, et al. "Enhanced Donor Antigen Presentation by B Cells Predicts Acute Cellular Rejection and Late Outcomes After Transplantation." Transplantation Direct 10, no. 3 (2024): e1589. http://dx.doi.org/10.1097/txd.0000000000001589.

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Background. Enhanced B-cell presentation of donor alloantigen relative to presentation of HLA-mismatched reference alloantigen is associated with acute cellular rejection (ACR), when expressed as a ratio called the antigen presenting index (API) in an exploratory cohort of liver and intestine transplant (LT and IT) recipients. Methods. To test clinical performance, we measured the API using the previously described 6-h assay in 84 LT and 54 IT recipients with median age 3.3 y (0.05–23.96). Recipients experiencing ACR within 60 d after testing were termed rejectors. Results. We first confirmed

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Reshef, Ran, Rosemarie Mick, Pavel Vassilev, et al. "Whole Blood Donor Chimerism At Day 30 After Reduced Intensity Conditioned Allogeneic Stem-Cell Transplantation Predicts Disease Relapse, and Is Strongly Associated with Pretransplant Lymphodepletion." Blood 118, no. 21 (2011): 1939. http://dx.doi.org/10.1182/blood.v118.21.1939.1939.

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Abstract Abstract 1939 Background: RIC SCT relies heavily on graft-versus-tumor alloreactivity, and relapse remains a major barrier to a favorable outcome. Early prediction of relapse would allow early intervention such as donor lymphocyte infusions (DLI), but factors that predict relapse and methods for detection of minimal residual disease are often disease specific and not standardized. The level of donor-recipient chimerism has been associated with both graft rejection and relapse, but the optimal timing, desired level, and predictive value of chimerism testing in RIC SCT are unclear. Furt

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Mishra, VikashChandra, Parvind Singh, AseemKumar Tiwari, et al. "New cost-effective human leukocyte antigen testing algorithm for screening of human leukocyte antigen-matched related donor in thalassemia major patient pretransplant workup: A single-center study from resource-constrained settings." Indian Journal of Community and Family Medicine 9, no. 1 (2023): 35. http://dx.doi.org/10.4103/ijcfm.ijcfm_20_22.

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Gupta, Aditi, Robert N. Montgomery, Victor Bedros, et al. "Subclinical Cognitive Impairment and Listing for Kidney Transplantation." Clinical Journal of the American Society of Nephrology 14, no. 4 (2019): 567–75. http://dx.doi.org/10.2215/cjn.11010918.

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Background and objectivesCognitive impairment is common in patients with kidney disease and can affect physicians’ perception and/or patients’ ability to complete the pretransplant evaluation. We examined whether cognitive impairment influences the likelihood for transplant listing and whether patients with cognitive impairment take longer to be listed.Design, setting, participants, & measurementsWe conducted a single-center longitudinal cohort study. Patients presenting for their index kidney transplant evaluation were screened for cognitive impairment using the Montreal Cognitive Assessm

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Geer, Lupita I., Sonya Kagele, Scot Townshend, Brooke Watson, Elaine F. Reed, and Michelle J. Hickey. "Design of a state of the art reporting system and process improvement for reporting of high complexity single antigen bead data for transplant patients to the electronic medical record." BMJ Open Quality 9, no. 1 (2020): e000813. http://dx.doi.org/10.1136/bmjoq-2019-000813.

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The UCLA Immunogenetics Center is an Immunogenetics and Histocompatibility laboratory that performs testing for multiple transplant programmes within and outside of UCLA. The single antigen bead (SAB) test is a high complexity luminex bead test used to assess pretransplant and post-transplant patients for the presence of pathogenic human leucocyte antigen donor-specific antibody associated with allograft rejection. Efficient reporting of the SAB test has been difficult as data analysis and reports are generated in the laboratory information system (LIS) and uploaded to the electronic medical r

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Nicolle, LE, A. Gutkin, G. Smart, et al. "Serological Studies of West Nile Virus in a Liver Transplant Population." Canadian Journal of Infectious Diseases and Medical Microbiology 15, no. 5 (2004): 271–74. http://dx.doi.org/10.1155/2004/606015.

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BACKGROUND: Solid organ transplant populations are at increased risk for serious clinical manifestations of West Nile virus (WNV) infection.OBJECTIVE: To monitor liver transplant recipients during the 2003 WNV season in Manitoba and to identify incidence, clinical presentation and serology.METHODS: Serial blood specimens were obtained from adult patients followed at the liver transplant outpatient clinic between May 2003 and October 2003. Studies for WNV infection included immunoglobulin (Ig) G and IgM enzyme immunoassay (EIA), hemagglutination inhibition (HI), plaque reduction neutralization

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Jones, Kenneth W., Thomas G. Peters, Ronald K. Charlton, et al. "Current issues in living donor nephrectomy." Clinical Transplantation 11, no. 5pt2 (1997): 505–10. http://dx.doi.org/10.1111/j.1399-0012.1997.tb01034.x.

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Of 96 consecutive renal transplants in 2 years, 50 (52%) were living donor grafts. Donor demographics, treatment plans, length of stay (LOS), charges, and complications were reviewed. Donors included 27 women and 23 men aged 22 to 61 (mean 42.2) years; 33 were living related and 17 living unrelated donors. Racial distribution included 1 Hispanic, 2 Asian, 8 black, and 39 white donors. Pretransplant evaluation defined renal anatomy and function (minimal creatinine clearance 75 cc/min). Hospital admission occurred the morning of donation. Nephrectomy under general anesthesia entailed an anterior

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Nervi, Bruno, Michael Rettig, Julie Ritchey, et al. "In Vivo Suicide Gene Therapy of Human T Lymphocytes To Prevent Graft Versus Host Disease in a Murine Xenograft Model." Blood 104, no. 11 (2004): 4979. http://dx.doi.org/10.1182/blood.v104.11.4979.4979.

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Abstract Graft-versus-host disease (GvHD) remains a major cause of morbidity and mortality following allogeneic stem cell transplantation. One approach to preserve the beneficial graft-versus-leukemia while minimizing GvHD is to genetically modify donor T cells with a herpes simplex virus thymidine kinase (HSV-tk) suicide gene that can selectively phosphorylate the prodrug ganciclovir (GCV) resulting in T cell suicide should GvHD develop. We recently developed a new chimeric suicide gene by fusing HSV-tk to the extracellular and transmembrane domains of human CD34 (ΔCD34-tk; Mol. Ther.2003; 8:

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