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Journal articles on the topic 'Primary amide'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Laclef, Sylvain, Maria Kolympadi Marković, and Dean Marković. "Amide Synthesis by Transamidation of Primary Carboxamides." Synthesis 52, no. 21 (2020): 3231–42. http://dx.doi.org/10.1055/s-0040-1707133.

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The amide functionality is one of the most important and widely used groups in nature and in medicinal and industrial chemistry. Because of its importance and as the actual synthetic methods suffer from major drawbacks, such as the use of a stoichiometric amount of an activating agent, epimerization and low atom economy, the development of new and efficient amide bond forming reactions is needed. A number of greener and more effective strategies have been studied and developed. The transamidation of primary amides is particularly attractive in terms of atom economy and as ammonia is the single

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2

Gautier, Yohan, Thierry Maris, and W. G. Skene. "Crystal structure of diethyl 2-amino-5-{4-[bis(4-methylphenyl)amino]benzamido}thiophene-3,4-dicarboxylate." Acta Crystallographica Section E Crystallographic Communications 75, no. 5 (2019): 589–92. http://dx.doi.org/10.1107/s2056989019003864.

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In the title compound, C31H31N3O5S, the regioselective substitution of the thiophene is confirmed with the amine and the amide at the 2- and 5-positions, respectively. In the molecule, the thiophene ring is twisted by 12.82 (3)° with respect to the aromatic ring of the benzamido group. Intramolecular N—H...O hydrogen bonds are present involving the N atoms of the primary amine and the amide groups, forming S(6) ring motifs. In the crystal, centrosymmetrically related molecules are linked by pairs of N—H...O hydrogen bonds involving the amide carbonyl O atoms and the primary amine N atoms to fo

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3

Liu, Jing, Shi-Meng Wang, Njud S. Alharbi, and Hua-Li Qin. "Installation of -SO2F groups onto primary amides." Beilstein Journal of Organic Chemistry 15 (August 9, 2019): 1907–12. http://dx.doi.org/10.3762/bjoc.15.186.

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A protocol of SO2F2-mediated installation of sulfonyl fluoride onto primary amides has been developed providing a new portal to sulfur(VI) fluoride exchange (SuFEx) click chemistry. The generated molecules contain pharmaceutically important amide and -SO2F moieties for application in the discovery of new therapeutics.

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4

Zahardis, J., S. Geddes, and G. A. Petrucci. "The ozonolysis of primary aliphatic amines in fine particles." Atmospheric Chemistry and Physics 8, no. 5 (2008): 1181–94. http://dx.doi.org/10.5194/acp-8-1181-2008.

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Abstract. The oxidative processing by ozone of the particulate amines octadecylamine (ODA) and hexadecylamine (HDA) is reported. Ozonolysis of these amines resulted in strong NO2– and NO3– ion signals that increased with ozone exposure as monitored by photoelectron resonance capture ionization aerosol mass spectrometry. These products suggest a mechanism of progressive oxidation of the particulate amines to nitroalkanes. Additionally, a strong ion signal at 125 m/z is assigned to the ion NO3– (HNO3). For ozonized mixed particles containing ODA or HDA + oleic acid (OL), with pO3≥3×10–7 atm, imi

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5

Kamanna, Kantharaju, S. Y. Khatavi, and P. B. Hiremath. "Microwave-assisted One-pot Synthesis of Amide Bond using WEB." Current Microwave Chemistry 7, no. 1 (2020): 50–59. http://dx.doi.org/10.2174/2213335606666190828114344.

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Background: Amide bond plays a key role in medicinal chemistry, and the analysis of bioactive molecular database revealed that the carboxamide group appears in more than 25% of the existing database drugs. Typically amide bonds are formed from the union of carboxylic acid and amine; however, the product formation does not occur spontaneously. Several synthetic methods have been reported for amide bond formation in literature. Present work demonstrated simple and eco-friendly amide bond formation using carboxylic acid and primary amines through in situ generation of O-acylurea. The reaction was

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6

Manjunath, M. S., P. Sivagurunathan, and J. Sannappa. "Studies of Hydrogen Bonding BetweenN, N-Dimethylacetamide and Primary Alcohols." E-Journal of Chemistry 6, s1 (2009): S143—S146. http://dx.doi.org/10.1155/2009/120362.

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Hydrogen bonding betweenN, N-dimethylacetamide (DMA) and alcohols has been studied in carbon tetrachloride solution by an X-band Microwave bench at 936GHz. The dielectric relaxation time (τ) of the binary system are obtained by both Higasi's method and Gopalakrishna method. The most likely association complex between alcohol and DMA is 1:1 stoichiometric complex through the hydroxyl group of the alcohol and the carbonyl group of amide. The results show that the interaction between alcohols and amides is 1:1 complex through the free hydroxyl group of the alcohol and the carbonyl group of amide

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7

Zahardis, J., S. Geddes, and G. A. Petrucci. "The ozonolysis of primary aliphatic amines in single and multicomponent fine particles." Atmospheric Chemistry and Physics Discussions 7, no. 5 (2007): 14603–38. http://dx.doi.org/10.5194/acpd-7-14603-2007.

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Abstract. The oxidative processing by ozone of the particulate amines octadecylamine (ODA) and hexadecylamine (HDA) is reported. Ozonolysis of these amines resulted in strong NO2− and NO3− ion signals that increased with ozone exposure as monitored by photoelectron resonance capture ionization aerosol mass spectrometry. These products suggest a mechanism of progressive oxidation of the particulate amines to nitro alkanes. Additionally, a strong ion signal at 125 m/z is assigned to the ion NO3−(HNO3). For ozonized mixed particles containing ODA or HDA + oleic acid (OL), with pO3≥3×10−7 atm, imi

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8

Reboul, Vincent, Nathalie Saraiva Rosa, Thomas Glachet, Quentin Ibert, Jean-François Lohier, and Xavier Franck. "A Straightforward Synthesis of N-Substituted Ureas from Primary Amides." Synthesis 52, no. 14 (2020): 2099–105. http://dx.doi.org/10.1055/s-0040-1707103.

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A direct and convenient method for the preparation of N-substituted ureas is achieved by treating primary amides with phenyliodine diacetate (PIDA) in the presence of an ammonia source (NH3 or ammonium carbamate) in MeOH. The use of 2,2,2-trifluoroethanol (TFE) as the solvent increases the electrophilicity of the hypervalent iodine species and allows the synthesis of electron-poor carboxamides. This transformation involves a nucleophilic addition of ammonia on the isocyanate intermediate generated in situ by a Hofmann rearrangement of the starting amide.

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9

Zarecki, Adam P., Jacek L. Kolanowski, and Wojciech T. Markiewicz. "Microwave-Assisted Catalytic Method for a Green Synthesis of Amides Directly from Amines and Carboxylic Acids." Molecules 25, no. 8 (2020): 1761. http://dx.doi.org/10.3390/molecules25081761.

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Amide bonds are among the most interesting and abundant molecules of life and products of the chemical pharmaceutical industry. In this work, we describe a method of the direct synthesis of amides from carboxylic acids and amines under solvent-free conditions using minute quantities of ceric ammonium nitrate (CAN) as a catalyst. The reactions are carried out in an open microwave reactor and allow the corresponding amides to be obtained in a fast and effective manner when compared to other procedures of the direct synthesis of amides from acids and amines reported so far in the literature. The

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10

Titmas, Richard C., Thelma S. Angeles, Renee Sugasawara, et al. "Aspects of antibody-catalyzed primary amide hydrolysis." Applied Biochemistry and Biotechnology 47, no. 2-3 (1994): 277–92. http://dx.doi.org/10.1007/bf02787940.

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11

Fisher, Lawrence E., Joan M. Caroon, S. Russell Stabler, et al. "Mild hydrolysis or alcoholysis of amides. Ti(IV) catalyzed conversion of primary carboxamides to carboxylic acids or esters." Canadian Journal of Chemistry 72, no. 1 (1994): 142–45. http://dx.doi.org/10.1139/v94-022.

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Reaction of primary amides (e.g., 1a or 6–13) or O-methylhydroxamates (1b and 1c) with a catalytic amount of TiCl4 and one equivalent of aqueous HCl converts these compounds in good yields to carboxylic esters (when an alcohol is used as solvent) or to carboxylic acids (when 9:1 dioxane:H2O is used as solvent). These conversions are chemoselective for primary amides: mono- and dialkyl amides are not affected by the reaction conditions. The hydrolysis conditions described do not compromise the stereochemical integrity of an adjacent chiral center. This is exemplified by the hydrolysis of naprox

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12

Markad, Datta, and Sanjay K. Mandal. "An exploration into the amide–pseudo amide hydrogen bonding synthon between a new coformer with two primary amide groups and theophylline." CrystEngComm 19, no. 47 (2017): 7112–24. http://dx.doi.org/10.1039/c7ce01666b.

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13

Agag, Tarek, Carlos R. Arza, Frans H. J. Maurer, and Hatsuo Ishida. "Primary Amine-Functional Benzoxazine Monomers and Their Use for Amide-Containing Monomeric Benzoxazines." Macromolecules 43, no. 6 (2010): 2748–58. http://dx.doi.org/10.1021/ma902556k.

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14

Schwieter, Kenneth E., and Jeffrey N. Johnston. "A one-pot amidation of primary nitroalkanes." Chemical Communications 52, no. 1 (2016): 152–55. http://dx.doi.org/10.1039/c5cc08415f.

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15

Grbović, Ljubica, Bojana Radovan Vasiljević, Ksenija Pavlović, et al. "Microwave-assisted synthesis of biologically active amide derivatives of naphthenic acids under neat conditions." Macedonian Journal of Chemistry and Chemical Engineering 37, no. 1 (2018): 13. http://dx.doi.org/10.20450/mjcce.2018.1371.

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Within the field of green chemistry, a noticeable results were obtained in the solvent-free synthesis of amide derivatives of naphthenic acids under microwave irradiation. Naphthenic acid amides, anilides, and morpholides were synthesized directly from free carboxylic acids and amines in the absence of solvent and catalyst under high-temperature heating in a closed-vessel system of microwave reactor. With this new and efficient method, different primary, secondary, and tertiary amide derivatives of naphthenic acids were obtained in good to excellent yields. Synthesized derivatives were assayed

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16

Sendker, Jandirk, and Adolf Nahrstedt. "Generation of primary amide glucosides from cyanogenic glucosides." Phytochemistry 70, no. 3 (2009): 388–93. http://dx.doi.org/10.1016/j.phytochem.2008.11.008.

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17

Al-Amily, Duraid, and Mohammed H. Mohammed. "Design, Synthesis and Cytotoxicity Study of Primary Amides as Histone Deacetylase Inhibitors." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 28, no. 2 (2019): 151–58. http://dx.doi.org/10.31351/vol28iss2pp151-158.

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Primary amide derivatives as histone deacetylase inhibitors (HDACIs) are very rare. This paper describes the synthesis of primary amide derivatives (compounds 6 and 7) that have the requirements to be histone deacetylase inhibitors of the zinc-binding type. Both of them exhibited good cytotoxicity against the tested cancer cell lines with much lower cytotoxicity against normal cell line.

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18

von Bülow, Rixa, Stephan Deuerlein, Thomas Stey, Regine Herbst-Irmer, Heinz Gornitzka, and Dietmar Stalke. "N-Aryl Anions: Half Way between Amides and Carbanions." Zeitschrift für Naturforschung B 59, no. 11-12 (2004): 1471–79. http://dx.doi.org/10.1515/znb-2004-11-1216.

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A ‘carbanion’ can coordinate to a metal like an ‘amide’ if there is a nitrogen atom present to withdraw electron density from the formally negatively charged carbon center. On the other hand, shifting the negative charge from the amido nitrogen atom to the carbon substituent should convert an ‘amidic’ into a ‘carbanionic’ coordination behavior. This seems feasible with various substituents at the aromatic ring in a primary amide. This paper is concerned with the influence of aromatic substitution, as well as with the nature of the metal ion on the coordination mode of an amide ligand. Discusse

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19

Krieck, Sven, Philipp Schüler, Jan Peschel, and Matthias Westerhausen. "Straightforward One-Pot Syntheses of Silylamides of Magnesium and Calcium via an In Situ Grignard Metalation Method." Synthesis 51, no. 05 (2018): 1115–22. http://dx.doi.org/10.1055/s-0037-1610407.

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Calcium bis[bis(trimethylsilyl)amide] (Ca(HMDS)2) is a widely used reagent in diverse stoichiometric and catalytic applications. These processes necessitate a straightforward and large-scale access of this complex. Calcium does not react with primary and secondary amines, but the addition of excess bromoethane to a mixture of calcium turnings and amines in THF at room temperature yields the corresponding calcium bis(amides), calcium bromide and ethane. This in situ Grignard metalation method (iGMM) allows the preparation of calcium bis(amides) from secondary and primary trialkylsilyl-substitut

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20

Nodzewska, Aneta, Agnieszka Wadolowska, Katarzyna Podgorska, Damian Pawelski, and Ryszard Lazny. "Synthesis of Solid-phase Supported Chiral Amines and Investigation of Stereoselectivity of Aldol Reactions of Amine-free Tropinone Enolate." Current Organic Chemistry 23, no. 17 (2019): 1867–79. http://dx.doi.org/10.2174/1385272823666190916145332.

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Seven selected chiral mono-, di-, and tridentate amines supported on insoluble polymer were effectively prepared from corresponding primary amines or secondary amino alcohols and Merrifield resin. The reaction of the polymer-supported amines with excess n-butyllithium gave the corresponding lithium amide bases, which were tested in the aldol reactions of tropinone with benzaldehyde. The deprotonation reactions were carried out with or without separation of the lithium enolate from polymer-supported reagents. Using the procedure with separation of lithium enolate from supported chiral reagent d

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21

Seo, Myungeun, Jeyoung Park, and Sang Youl Kim. "Self-assembly driven by an aromatic primary amide motif." Organic & Biomolecular Chemistry 10, no. 28 (2012): 5332. http://dx.doi.org/10.1039/c2ob25117e.

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22

Xie, Zengyang, Ruijiao Chen, Zhongyu Du, et al. "Iodine-Catalyzed Formation of Amide Bond: Efficient Strategy for the Synthesis of Aromatic Primary Amides." Asian Journal of Organic Chemistry 6, no. 2 (2016): 157–60. http://dx.doi.org/10.1002/ajoc.201600532.

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23

Grigg, Ronald, Xinjie Gai, Tossapol Khamnaen, et al. "Synthesis of N-substituted isoindolinones via a palladium catalysed three-component carbonylation amination Michael addition cascade." Canadian Journal of Chemistry 83, no. 6-7 (2005): 990–1005. http://dx.doi.org/10.1139/v05-111.

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We herein describe a novel palladium catalysed three-component cascade process involving carbonylation of an aryl iodide to generate an acyl palladium(II) species that is intercepted by a primary aliphatic or aromatic amine, amide, or sulfonamide followed by intramolecular Michael addition to furnish N-substituted isoindolinones in good yield. Overall, the cascade results in the formation of one CC and two CN bonds, one ring and one stereocentre.Key words: isoindolinone, palladium, cascade, amidation, sulfonamidation.

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24

Li, Jifeng, Ting Fang, Wenjing Yan, Fei Zhang, Yunhui Xu, and Zhaofang Du. "Structure and Properties of Oxidized Chitosan Grafted Cashmere Fiber by Amide Covalent Modification." Molecules 25, no. 17 (2020): 3812. http://dx.doi.org/10.3390/molecules25173812.

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In this study, oxidized chitosan grafted cashmere fibers (OCGCFs) were obtained by crosslinking the oxidized chitosan onto cashmere fibers by amide covalent modification. A novel method was developed for the selective oxidation of the C6 primary hydroxyls into carboxyl groups for chitosan. The effect of oxidization reaction parameters of HNO3/H3PO4–NaNO2 mediated oxidation system on the oxidation degree, structure, and properties of chitosan were investigated. The chemical structure of the oxidized chitosan was characterized by solid-state cross-polarization magic angle spinning carbon-13 Nucl

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25

Kumagai, Naoya, Masakatsu Shibasaki, and Shinya Adachi. "Thieme Chemistry Journals Awardees – Where Are They Now? Bis(2-pyridyl)amides as Readily Cleavable Amides Under Catalytic, Neutral, and Room-Temperature Conditions." Synlett 29, no. 03 (2017): 301–5. http://dx.doi.org/10.1055/s-0036-1590932.

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Mild solvolytic cleavage of bis(2-pyridyl)amide under neutral and room-temperature conditions is described. The inherently stable amide was readily activated by catalytic amounts of metal cations to react with alcohols. Based on X-ray crystallographic analysis, the primary driving force was considered to be amide distortion induced by the metal coordination of two pyridyl groups in a bidentate fashion without affecting the amide functionality. The compatibility of the acid/base-sensitive functionalities and the absence of racemization during solvolysis highlight the mildness of the present pro

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26

Thakkar, Balmukund, John Svendsen, and Richard Engh. "Density Functional Studies on Secondary Amides: Role of Steric Factors in Cis/Trans Isomerization." Molecules 23, no. 10 (2018): 2455. http://dx.doi.org/10.3390/molecules23102455.

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Cis/trans isomerization of amide bonds is a key step in a wide range of biological and synthetic processes. Occurring through C-N amide bond rotation, it also coincides with the activation of amides in enzymatic hydrolysis. In recently described QM studies of cis/trans isomerization in secondary amides using density functional methods, we highlighted that a peptidic prototype, such as glycylglycine methyl ester, can suitably represent the isomerization and complexities arising out of a larger molecular backbone, and can serve as the primary scaffold for model structures with different substitu

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27

Dréan, Mathilde, Philippe Guégan, Christine Jérôme, Jutta Rieger, and Antoine Debuigne. "Far beyond primary poly(vinylamine)s through free radical copolymerization and amide hydrolysis." Polymer Chemistry 7, no. 1 (2016): 69–78. http://dx.doi.org/10.1039/c5py01325a.

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28

Shahmiri, Mahdi, and Adam Mechler. "The role of C-terminal amidation in the mechanism of action of the antimicrobial peptide aurein 1.2." EuroBiotech Journal 4, no. 1 (2020): 25–31. http://dx.doi.org/10.2478/ebtj-2020-0004.

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AbstractC-terminal amidation is a common feature of wild type membrane disrupting antimicrobial peptides (AMPs). Empirical evidence suggests that this modification increases antimicrobial efficacy. However, the actual role of C-terminal amidation in the molecular mechanism of action of AMPs is not fully understood. Amidation alters two key properties simultaneously: the net charge and helicity of the peptide, both of which are implicated in the mechanism of action. However, the differences between the physicochemical properties of the carboxyl and amide moieties have been disregarded in former

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29

Wang, Cuiling, Xiao Bai, Rui Wang, et al. "Synthesis of Imatinib by C–N Coupling Reaction of Primary Amide and Bromo-Substituted Pyrimidine Amine." Organic Process Research & Development 23, no. 9 (2019): 1918–25. http://dx.doi.org/10.1021/acs.oprd.9b00227.

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30

Deneva, Vera, Georgi Dobrikov, Aurelien Crochet, Daniela Nedeltcheva, Katharina M. Fromm, and Liudmil Antonov. "Tautomerism as primary signaling mechanism in metal sensing: the case of amide group." Beilstein Journal of Organic Chemistry 15 (August 8, 2019): 1898–906. http://dx.doi.org/10.3762/bjoc.15.185.

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The concept for sensing systems using the tautomerism as elementary signaling process has been further developed by synthesizing a ligand containing 4-(phenyldiazenyl)naphthalene-1-ol as a tautomeric block and an amide group as metal capturing antenna. Although it has been expected that the intramolecular hydrogen bonding (between the tautomeric hydroxy group and the nitrogen atom from the amide group) could stabilize the pure enol form in some solvents, the keto tautomer is also observed. This is a result from the formation of intramolecular associates in some solvents. Strong bathochromic an

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31

Hemraz, Usha D., Yaman Boluk, and Rajesh Sunasee. "Amine-decorated nanocrystalline cellulose surfaces: synthesis, characterization, and surface properties." Canadian Journal of Chemistry 91, no. 10 (2013): 974–81. http://dx.doi.org/10.1139/cjc-2013-0165.

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In this present work, terminal amino-functionalized nanocrystalline cellulose derivatives were prepared using a simple two-step protecting group-free protocol under aqueous reaction conditions at room temperature. Carboxylate groups were first introduced onto the surface of nanocrystalline cellulose (NCC) via a TEMPO-mediated oxidation. Then, reaction of surface-carboxylated NCC with bifunctional amines of small alkyl chain length by EDC/NHS-mediated coupling furnished the desired aminated NCC via an amide linkage. Surface covalent functionalization was confirmed by Fourier transform infrared

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32

Stenholm, Åke, Anders Backlund, Sara Holmström, Maria Backlund, Mikael Hedeland, and Petra Fransson. "Survival and growth of saprotrophic and mycorrhizal fungi in recalcitrant amine, amide and ammonium containing media." PLOS ONE 16, no. 9 (2021): e0244910. http://dx.doi.org/10.1371/journal.pone.0244910.

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The elimination of hazardous compounds in chemical wastes can be a complex and technically demanding task. In the search for environmental-friendly technologies, fungal mediated remediation and removal procedures are of concern. In this study, we investigated whether there are fungal species that can survive and grow on solely amine-containing compounds. One compound containing a primary amine group; 2-diethylaminoethanol, one compound with a primary amide group; 2,6-dichlorobenzamide (BAM), and a third compound containing a quaternary ammonium group; N3-trimethyl(2-oxiranyl)methanaminium chlo

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33

Satavalekar, Sneha D., Prashant B. Savvashe, and Shashank T. Mhaske. "Triester–amide based on thiophene and ricinoleic acid as an innovative primary plasticizer for poly(vinyl chloride)." RSC Advances 6, no. 116 (2016): 115101–12. http://dx.doi.org/10.1039/c6ra20098b.

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34

Robb, Sandra, Leonard C. Packman, and Peter D. Evans. "Isolation, primary structure and bioactivity of schistoflrf-amide, a FMRF-amide-like neuropeptide from the locust, Schistocerca gregaria." Biochemical and Biophysical Research Communications 160, no. 2 (1989): 850–56. http://dx.doi.org/10.1016/0006-291x(89)92512-6.

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35

Hoque, Mahfuzul, Morgan L. Thomas, Muhammed Shah Miran, et al. "Protic ionic liquids with primary alkylamine-derived cations: the dominance of hydrogen bonding on observed physicochemical properties." RSC Advances 8, no. 18 (2018): 9790–94. http://dx.doi.org/10.1039/c8ra00402a.

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36

Sajiki, Hironao, Yoshinari Sawama, Shota Asai, Kazuho Ban, and Yasunari Monguchi. "Selective N-Monoalkylation of Amide Derivatives with Trialkyl Phosphates." Synlett 29, no. 03 (2017): 322–25. http://dx.doi.org/10.1055/s-0036-1591494.

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A highly selective and easily handled monoalkylation of primary amide derivatives by using trialkyl phosphates as alkylating reagents in cyclopentyl methyl ether (CPME) was developed. Various monoalkylated amide derivatives were efficiently synthesized by changing the alkyl moiety (e.g., methyl, ethyl, butyl, or benzyl) of the trialkyl phosphate. These phosphate reagents are relatively stable and easily available, and CPME is a useful solvent in process chemistry.

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37

VanderWeide, Andrew I., Richard J. Staples, and Shannon M. Biros. "Crystal structures of two bis-carbamoylmethylphosphine oxide (CMPO) compounds." Acta Crystallographica Section E Crystallographic Communications 75, no. 7 (2019): 991–96. http://dx.doi.org/10.1107/s205698901900820x.

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Two bis-carbamoylmethylphosphine oxide compounds, namely {[(3-{[2-(diphenylphosphinoyl)ethanamido]methyl}benzyl)carbamoyl]methyl}diphenylphosphine oxide, C36H34N2O4P2, (I), and diethyl [({2-[2-(diethoxyphosphinoyl)ethanamido]ethyl}carbamoyl)methyl]phosphonate, C14H30N2O8P2, (II), were synthesized via nucleophilic acyl substitution reactions between an ester and a primary amine. Hydrogen-bonding interactions are present in both crystals, but these interactions are intramolecular in the case of compound (I) and intermolecular in compound (II). Intramolecular π–π stacking interactions are also pr

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38

Oliveira, Andrea Fernandes de, Ivan Dunshee de Abranches Oliveira Santos, Sidney Bandeira Cartaxo, et al. "Differential diagnosis in primary and metastatic cutaneous melanoma by FT-Raman spectroscopy." Acta Cirurgica Brasileira 25, no. 5 (2010): 434–39. http://dx.doi.org/10.1590/s0102-86502010000500009.

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PURPOSE: To qualify the FT-Raman spectral data of primary and metastatic cutaneous melanoma in order to obtain a differential diagnosis. METHODS: Ten normal human skin samples without any clinical or histopathological alterations, ten cutaneous melanoma fragments, and nine lymph node metastasis samples were used; 105, 140 and 126 spectra were obtained respectively. Each sample was divided into 2 or 3 fragments of approximately 2 mm³ and positioned in the Raman spectrometer sample holder in order to obtain the spectra; a monochrome laser light Nd:YAG at 1064 nm was used to excite the inelastic

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39

Protiva, Miroslav, Zdeněk Šedivý, Jiří Holubek, Emil Svátek, and Jiří Němec. "Cyclic amidines derived from benz[c,d]indole and 4,5-dihydro-3H-1-benzazepine including some related compounds: Synthesis and pharmacological screening." Collection of Czechoslovak Chemical Communications 50, no. 8 (1985): 1888–98. http://dx.doi.org/10.1135/cccc19851888.

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Reactions of naphthostyril (I) with primary and secondary amines and titanium tetrachloride afforded cyclic amidines III-IX. Hydrogenation of I on Pd-C resulted in the 6,7,8,8a-tetrahydro derivative X which gave by treatment with sodium amide and 3-dimethylaminopropyl chloride the N-(aminoalkyl) compound XI. Reduction of I and its N-methyl derivative II with sodium amalgam in aqueous sodium hydroxide gave the 2a,3,4,5-tetrahydro derivatives XII and XIII. Reaction of XIII with sodium amide and 3-dimethylaminopropyl chloride afforded the 2a-(aminoalkyl) compound XIV. 1,3,4,5-Tetrahydro-1-benzaze

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40

Ip, Wilfred, Weijuan Shao, Yu-ting Alex Chiang, and Tianru Jin. "GLP-1-derived nonapeptide GLP-1(28–36)amide represses hepatic gluconeogenic gene expression and improves pyruvate tolerance in high-fat diet-fed mice." American Journal of Physiology-Endocrinology and Metabolism 305, no. 11 (2013): E1348—E1358. http://dx.doi.org/10.1152/ajpendo.00376.2013.

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Certain “degradation” products of GLP-1 were found to possess beneficial effects on metabolic homeostasis. Here, we investigated the function of the COOH-terminal fragment of GLP-1, the nonapeptide GLP-1(28–36)amide, in hepatic glucose metabolism. C57BL/6 mice fed a high-fat diet (HFD) for 13 wk were injected intraperitoneally with GLP-1(28–36)amide for 6 wk. A significant reduction in body weight gain in response to HFD feeding was observed in GLP-1(28–36)amide-treated mice. GLP-1(28–36)amide administration moderately improved glucose disposal during glucose tolerance test but more drasticall

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41

Rolland, Marc, Marie-Françoise Lignon, Marie-Christine Galas, et al. "On the significance of the C-terminal primary amide in cholecystokinin." Bioorganic & Medicinal Chemistry Letters 3, no. 5 (1993): 851–54. http://dx.doi.org/10.1016/s0960-894x(00)80679-4.

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Jaiswal, Yogesh, Yogesh Kumar, Rima Thakur, Jagannath Pal, Ranga Subramanian, and Amit Kumar. "Primary Amide Directed Regioselective ortho-C–H-Arylation of (Aryl)Acetamides." Journal of Organic Chemistry 81, no. 24 (2016): 12499–505. http://dx.doi.org/10.1021/acs.joc.6b02353.

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Zhao, Ren, та Wenjun Lu. "Palladium-Catalyzed β-Arylation of Amide via Primary sp3C–H Activation". Organometallics 37, № 13 (2018): 2188–92. http://dx.doi.org/10.1021/acs.organomet.8b00325.

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Seo, Myungeun, Jeyoung Park, and Sang Youl Kim. "ChemInform Abstract: Self-Assembly Driven by an Aromatic Primary Amide Motif." ChemInform 43, no. 49 (2012): no. http://dx.doi.org/10.1002/chin.201249237.

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Onoprienko, V. V., E. A. Yelin, and A. I. Miroshnikov. "The hydrolysis of primary amide groups in Asn/Gln-containing peptides." Russian Journal of Bioorganic Chemistry 26, no. 6 (2000): 361–68. http://dx.doi.org/10.1007/bf02758662.

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Wood, Thomas J., Joshua W. Makepeace, Hazel M. A. Hunter, Martin O. Jones, and William I. F. David. "Isotopic studies of the ammonia decomposition reaction mediated by sodium amide." Physical Chemistry Chemical Physics 17, no. 35 (2015): 22999–3006. http://dx.doi.org/10.1039/c5cp03560k.

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Topolyan, A. P., M. A. Belyaeva, E. E. Bykov, et al. "Derivatization of Aminoglycoside Antibiotics with Tris(2,6-dimethoxyphenyl)carbenium Ion." Acta Naturae 8, no. 3 (2016): 128–35. http://dx.doi.org/10.32607/20758251-2016-8-3-128-135.

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Detection of aminoglycoside antibiotics by MS or HPLC is complicated, because a) carbohydrate molecules have low ionization ability in comparison with other organic molecules (particularly in MALDI-MS), and b) the lack of aromatics and/or amide bonds in the molecules makes common HPLC UV-detectors useless. Here, we report on the application of a previously developed method for amine derivatization with tris(2,6-dimethoxyphenyl)carbenium ion to selective modification of aminoglycoside antibiotics. Only amino groups bound to primary carbons get modified. The attached aromatic residue carries a p

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Bacchi, A., G. Cantoni, D. Crocco, M. Granelli, P. Pagano, and P. Pelagatti. "Hydrogen-bond networks in polymorphs and solvates of metallorganic complexes containing ruthenium and aminoamide ligands." CrystEngComm 16, no. 6 (2014): 1001–9. http://dx.doi.org/10.1039/c3ce41920g.

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Nguyen, D. Thao, Danny C. Lenstra, and Jasmin Mecinović. "Chemoselective calcium-catalysed direct amidation of carboxylic esters." RSC Advances 5, no. 95 (2015): 77658–61. http://dx.doi.org/10.1039/c5ra18288c.

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Ivanovic, Milovan, I. V. Micovic, Sonja Vuckovic, et al. "The synthesis and pharmacological evaluation of (±)-2, 3- seco-fentanyl analogues." Journal of the Serbian Chemical Society 69, no. 11 (2004): 955–68. http://dx.doi.org/10.2298/jsc0411955i.

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An efficient, five-step synthetic approach to various acyclic 1,3-diamines has been developed and applied to the preparation of a novel class of open-chained fentanyl analogues. The acyclic derivatives 5.1?5.5 (all new compounds) were synthesized with the aim of estimating the significance of the piperidine ring for the opioid analgesic activity of anilido-piperidines. The starting ?-keto-amide 1.1, prepared by the aminolysis of methyl acetoacetate with methylphenethylamine, (93 % yield), was successively reacted with NaH and BuLi, to form the highly reactive ?,?-dienolate anion 1.1a. Regio an

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