Log in

Relevant bibliographies by topics / Primary cell culture of bivalve / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Primary cell culture of bivalve.

Dissertations / Theses on the topic 'Primary cell culture of bivalve'

Author: Grafiati

Published: 8 June 2024

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Primary cell culture of bivalve.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Fleurbaix, Emmanuel. "Évaluation écotoxicologique des éléments terres-rares : approches cellulaires chez différentes espèces aquatiques." Electronic Thesis or Diss., Université de Lorraine, 2021. http://www.theses.fr/2021LORR0324.

Full text

Abstract:

Depuis 30 ans, l’utilisation croissante des Lanthanides dans les nouvelles technologies a entraîné des rejets importants de ces métaux vers les écosystèmes aquatiques. Dans une politique mondiale de développement durable visant à préserver la qualité des écosystèmes, la question de l’impact des Lanthanides sur les organismes aquatiques s’est naturellement posée. Néanmoins, les études restent peu nombreuses et aucun consensus ne subsiste concernant la toxicité des Lanthanides. Dans ce contexte, nous avons étudié la toxicité cellulaire des Lanthanides individuellement et en mélanges. Les effets

APA, Harvard, Vancouver, ISO, and other styles

2

Birmelin, Claudia. "Development of primary cell culture systems from marine invertebrates for use in toxicology." Thesis, University of Surrey, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265684.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Bohm, Maren [Verfasser]. "The role of sialic acids in avian influenza virus infection of primary cell culture / Maren Bohm." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2010. http://d-nb.info/1004206291/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Tradewell, Miranda Lee. "The central role of calcium dysregulation in a primary cell culture model of amyotrophic lateral sclerosis." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32355.

Full text

Abstract:

Amyotrophic lateral sclerosis (ALS; aka Lou Gehrig Disease) is an adult-onset, rapidly progressing motor neuron disease for which there is currently very little treatment. Glutamate excitoxicity, formation of proteinaceous inclusions, proteasome impairment, and mitochondrial dysfunction have been associated with both sporadic and familial ALS, but there are many questions about how these events fit together to cause motor neuron dysfunction and death. In culture models of familial ALS due to mutations in

APA, Harvard, Vancouver, ISO, and other styles

5

Stab, II Bernd Robert. "The Effects of Cell Culture Oxygen Levels on the Replicative Senescence Processes of Primary Human Fibroblasts." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/28468.

Full text

Abstract:

Serial passaging of primary human fibroblasts leads to the formation of non-dividing senescent cells by a process termed replicative senescence. This tissue culture-based methodology is currently used as a model system to determine the underlying mechanisms of in vivo cellular aging and tumor suppression. Senescence is regarded as an alternative pathway to apoptosis, where cells undergo multiple changes in metabolic and cellular signaling pathways in order to prevent proliferation but still maintain a metabolically-active cell. Whether or not this model accurately reflects in vivo processes is

APA, Harvard, Vancouver, ISO, and other styles

6

Hang, Ta-Chun. "Optimization of primary endothelial culture methods and assessment of cell signaling pathways in the context of inflammation." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/71467.

Full text

Abstract:

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Tissue engineering is a potentially valuable tool for clinical treatment of diseases where host tissues or organs need to be replaced. Progression of engineering metabolically complex organs and tissues has been severely limited by the lack of established, functional vasculature. The thesis work described herein focused on methods of establishing and studying specific endothelial cell types in vitro for potential appl

APA, Harvard, Vancouver, ISO, and other styles

7

Kraft, Robert, Allon Kahn, José L. Medina-Franco, et al. "A cell-based fascin bioassay identifies compounds with potential anti-metastasis or cognition-enhancing functions." The Company of Biologists, 2013. http://hdl.handle.net/10150/605272.

Full text

Abstract:

A first-of-its-kind, proof-of-concept drug screen with implications for two unmet medical needs.<br>The actin-bundling protein fascin is a key mediator of tumor invasion and metastasis and its activity drives filopodia formation, cell-shape changes and cell migration. Small-molecule inhibitors of fascin block tumor metastasis in animal models. Conversely, fascin deficiency might underlie the pathogenesis of some developmental brain disorders. To identify fascin-pathway modulators we devised a cell-based assay for fascin function and used it in a bidirectional drug screen. The screen utilized c

APA, Harvard, Vancouver, ISO, and other styles

8

Klingbeil, Maria Fátima Guarizo. ""Comparação de dois métodos de obtenção celular para cultura primária de queratinócitos bucais humanos"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-17052007-144619/.

Full text

Abstract:

Freqüentemente as condutas terapêuticas utilizadas no tratamento de patologias bucais são cirúrgicas, resultando em falhas de continuidade da mucosa bucal. A possibilidade de obtenção de epitélios transplantáveis, a partir do cultivo in vitro de células da mucosa bucal, abre novas perspectivas de utilização, não se restringindo somente ao seu local de origem, ou seja, a boca, mas também como material de reconstrução para outras regiões, tais como: uretra, córnea, superfície ocular e epitélio córneo-limbal. Os métodos utilizados para a obtenção dessas células ainda são controversos na literatur

APA, Harvard, Vancouver, ISO, and other styles

9

Song, Miyeoun. "Organ and primary culture of medaka (Oryzias latipes) testis: Test systems for the analysis of cell proliferation and differentiation." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2003. http://nbn-resolving.de/urn:nbn:de:swb:14-1059039500031-89370.

Full text

Abstract:

In cultured medaka testis fragments, cells remained viable for the entire culture period (17h), and spermatids that developed from spermatocytes were viable and motile. Primary cultures were characterized over a period of two days with respect to cell viability and the distribution of adherent and suspended cells. These two cell populations were maintained in dynamic equilibrium in vitro for several days. Proliferating cells were predominant among clusters of suspended cells, as determined by BrdU labeling, and CFSE and propidium iodide PI labeling. Based on cytological criteria, the prolifera

APA, Harvard, Vancouver, ISO, and other styles

10

Geyer, Simone [Verfasser], and S. [Akademischer Betreuer] Scholpp. "Establishment of a three-dimensional cell culture system to study tubular structures - A comparative study of neuronal differentiation in zebrafish and in 2D and 3D zebrafish primary cell culture / Simone Geyer. Betreuer: S. Scholpp." Karlsruhe : KIT-Bibliothek, 2015. http://d-nb.info/1112224580/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Mahat, Bimit. "The Effects of Hypoxia on Human Adipose Tissue Lipid Storage and Mobilization Functions: From Primary Cell Culture to Healthy Men." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36865.

Full text

Abstract:

Adipose tissue plays a central role in the regulation of lipid storage and mobilization. A tight control between adipose tissue lipid storage and mobilization functions must be exerted to prevent an overload of lipids at other organs such as the heart, liver and skeletal muscles, and favor the risk of developing metabolic disorders, such as Type 2 diabetes and cardiovascular diseases (CVD). There is strong evidence from animal studies that low oxygen levels (hypoxia) are noted in adipose tissue as the mass of the organ excessively expands and, in turn, exacerbates some adipose tissue functions

APA, Harvard, Vancouver, ISO, and other styles

12

Gaffuri, Anne-Lise. "Drosophila melanogaster, as a model system to study the cell biology of neuronal GPCRs." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05T063.

Full text

Abstract:

Le récepteur cannabinoique de type 1 (CB1R) est l’un des récepteurs couplés aux protéines G les plus abondants du cerveau mammifère. CB1R a longtemps été décrit comme un récepteur présynaptique régulant de manière rétrograde la transmission synaptique. Cependant, depuis les vingt dernières années, de nouveaux rôles ont été découverts et il est maintenant clairement admis que l’action des endocannabinoides (eCBs) ne se limite pas à la régulationde la neurotransmission au niveau de synapses adultes déjà établies. En effet, les eCBs et le CB1R sont des acteurs majeurs de l’ensemble des phases du

APA, Harvard, Vancouver, ISO, and other styles

13

Guan, Haoji. "Double-stranded RNA induced gene silencing of neuropeptide genes in sand shrimp, Metapenaeus ensis and development of crustacean primary cell culture /." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36893626.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Tirnitz-Parker, Janina Elke Eleonore. "Primary culture and immortal cell lines as in vitro models to evaluate the role of TWEAK signalling in hepatic oval cells /." Connect to this title, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0039.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Gonsalves, Kyle Joseph. "An exploration of RNA and miRNA expression and their role in cell cycle regulation of human primary trabecular meshwork cells." Thesis, University of Iowa, 2019. https://ir.uiowa.edu/etd/6744.

Full text

Abstract:

In the Kuehn lab, it has been shown that inducible pluripotent stems cells that have been induced to be trabecular meshwork cell-like (iPSC-TM) have a unique ability to regenerate dysfunctional trabecular meshwork (TM) cells by sharing specific unknown factors. In this thesis will discuss the novel means by which I isolate primary human Trabecular Meshwork (pTMs) and efficiently prepare cell cultures for experimentation, such as a sequencing experiment in which I studied expression changes that arose when the TM cell culture’s cell cycle control is manipulated. Previous research has shown that

APA, Harvard, Vancouver, ISO, and other styles

16

Daukste, Liene. "Mathematical Modelling of Cancer Cell Population Dynamics." Thesis, University of Canterbury. Department of Mathematics and Statistics, 2012. http://hdl.handle.net/10092/10057.

Full text

Abstract:

Mathematical models, that depict the dynamics of a cancer cell population growing out of the human body (in vitro) in unconstrained microenvironment conditions, are considered in this thesis. Cancer cells in vitro grow and divide much faster than cancer cells in the human body, therefore, the effects of various cancer treatments applied to them can be identified much faster. These cell populations, when not exposed to any cancer treatment, exhibit exponential growth that we refer to as the balanced exponential growth (BEG) state. This observation has led to several effective methods of estimat

APA, Harvard, Vancouver, ISO, and other styles

17

Chow, Sheung Ching. "The characterization of hyperosomotic stress-induced signaling cascades and the downstream effectors in primary gill cell culture of Japanese eels, Anguilla japonica." HKBU Institutional Repository, 2010. http://repository.hkbu.edu.hk/etd_ra/1182.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Pitombo, Jonleno Coutinho Paiva [UNESP]. "Impacto de andrógenos na diferenciação e atividade de osteoclastos em cultura celular." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/138870.

Full text

Abstract:

Submitted by JONLENO COUTINHO PAIVA PITOMBO null (jomtombo@hotmail.com) on 2016-05-23T15:01:17Z No. of bitstreams: 1 Jonleno Coutinho P Pitombo.pdf: 2907326 bytes, checksum: b153a02592cf15ac920e757f91e472b8 (MD5)<br>Approved for entry into archive by Ana Paula Grisoto (grisotoana@reitoria.unesp.br) on 2016-05-25T16:58:23Z (GMT) No. of bitstreams: 1 pitombo_jcp_me_arafo.pdf: 2907326 bytes, checksum: b153a02592cf15ac920e757f91e472b8 (MD5)<br>Made available in DSpace on 2016-05-25T16:58:23Z (GMT). No. of bitstreams: 1 pitombo_jcp_me_arafo.pdf: 2907326 bytes, checksum: b153a02592cf15ac920e757

APA, Harvard, Vancouver, ISO, and other styles

19

Abd, el Rahman Sahar El Sayed El Sayed Ali [Verfasser]. "Comparative analysis of current infectious bronchitis virus isolates in primary cell culture systems / Sahar El Sayed El Sayed Ali Abd El Rahman." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2010. http://d-nb.info/1009660683/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Stott, Lucy Claire. "Development and uses of a primary fish gill cell culture system to investigate the uptake, efflux and metabolism of pharmaceuticals in ecotoxicology." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/development-and-uses-of-a-primary-fish-gill-cell-culture-system-to-investigate-the-uptake-efflux-and-metabolism-of-pharmaceuticals-in-ecotoxicology(4213e713-7048-441b-aa06-044e4baf768e).html.

Full text

Abstract:

Worldwide, many animals are used in regulatory and academic studies to determine the environmental fate and impact of xenobiotic compounds that may be released into the environment. Fish are commonly used in these tests as they inhabit the aquatic environment, the sink into which many pharmaceuticals eventually enter. Fish gills are the primary site of xenobiotic uptake. In line with the replacement, reduction and refinement (3Rs) of the use of animals in scientific practices, alternative methods to in vivo fish testing are required. For rainbow trout (Oncorhynchus mykiss), a commonly used spe

APA, Harvard, Vancouver, ISO, and other styles

21

Iji, Oluwafikemi Temitayo. "In vitro bioassays as tools for evaluating toxicity of acidic drainage from a coal mine in Mpumalanga, South Africa." Thesis, University of Pretoria, 2016. http://hdl.handle.net/2263/60126.

Full text

Abstract:

Coal mining and coal utilization in Mpumalanga have increased over the years due to national reliance on coal as a source of power generation. In general, this has caused significant deterioration of water quality wherever streams are impacted by acid mine drainage (AMD). The aim of this research was to assess the use of in vitro bioassays as a complement to, or potential future replacement of, waste effluent testing in whole animals from AMD impacted watersheds subjected to passive and active treatment, correlating observed changes with water chemistry analysis. To accomplish this goal, water

APA, Harvard, Vancouver, ISO, and other styles

22

Monterosso, Melissa Eileen. "The Microwell-mesh platform: A multifaceted microtissue technology to link cell culture, animal models and patients." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/236375/1/Melissa_Monterosso_Thesis.pdf.

Full text

Abstract:

Work towards effective translational medicine has revealed that current in vitro platforms are not sufficient to produce relevant clinical results. Advances in 3D technologies and preclinical models must be made to address the gaps lead to failure of initially promising therapies. The Microwell-mesh platform is a versatile device demonstrated to help bridge this gap. The device within the context of completed work was used to not only generate cancer xenograft models, crucial for successful personalized cancer therapeutics, but was also used to investigate the capacity of adult mesenchymal ste

APA, Harvard, Vancouver, ISO, and other styles

23

Nakajima, Aya. "Radiation sensitivity assay with a panel of patient-derived spheroids of small cell carcinoma of the cervix." Kyoto University, 2015. http://hdl.handle.net/2433/199178.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Okolicsanyi, Rachel K. "Mesenchymal stem cells as mediators of the neuronal cell niche." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/84485/1/Rachel_Okolicsanyi_Thesis.pdf.

Full text

Abstract:

This study examined the role of heparan sulfate proteoglycans (HSPGs) in neural lineage differentiation of human mesenchymal stem cells (hMSCs). Several HSPGs were identified as potential new targets controlling neural fate specification and may be applied to the development of improved models to examine and repair brain damage. hMSCs were characterised throughout extended in vitro expansion for neural lineage potential (neurons, astrocytes, oligodendrocytes) and differentiated using terminal differentiation and intermediate sphere formation. Brain damage and neurological disorders caused by i

APA, Harvard, Vancouver, ISO, and other styles

25

Pinello, Katia Cristina. "Avaliação da quimiosensibilidade de mastocitomas caninos graus I, II e III ao ácido retinóico todo-trans." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-02032007-090228/.

Full text

Abstract:

O mastocitoma é o tumor cutâneo mais comum dos cães, representando 7% a 21% dos tumores da pele e tecidos moles, 11% a 27% dos tumores malignos cutâneos nessa espécie. Eles possuem uma grande variedade de aparência e comportamento, o qual o torna um desafio seu tratamento. Os retinóides são uma promessa na luta contra o câncer. Entretanto, há poucos estudos sobre os efeitos dos retinóides em neoplasias caninas. O presente trabalho teve como objetivo caracterizar a cultura primária de mastocitomas caninos assim como investigar a quimiosensibilidade deste tumor ao ácido retinóico todo-trans (ATR

APA, Harvard, Vancouver, ISO, and other styles

26

Khaghani, Seyed A. "Cell and tissue engineering of articular cartilage via regulation and alignment of primary chondrocyte using manipulated transforming growth factors and ECM proteins. Effect of transforming growth factor-beta (TGF-¿1, 2 and 3) on the biological regulation and wound repair of chondrocyte monolayers with and without presence of ECM proteins." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/5371.

Full text

Abstract:

Articular cartilage is an avascular and flexible connective tissue found in joints. It produces a cushioning effect at the joints and provides low friction to protect the ends of the bones from wear and tear/damage. It has poor repair capacity and any injury can result pain and loss of mobility. One of the common forms of articular cartilage disease which has a huge impact on patient¿s life is arthritis. Research on cartilage cell/tissue engineering will help patients to improve their physical activity by replacing or treating the diseased/damaged cartilage tissue. Cartilage cell, called chon

APA, Harvard, Vancouver, ISO, and other styles

27

Pitombo, Jonleno Coutinho Paiva. "Impacto de andrógenos na diferenciação e atividade de osteoclastos em cultura celular /." Araraquara, 2016. http://hdl.handle.net/11449/138870.

Full text

Abstract:

Orientador: Luis Carlos Spolidorio<br>Banca: Ticiana Sidorenko de Oliveira Capone<br>Banca: Thallita Pereira Queiroz<br>Resumo: Os mecanismos de ação dos andrógenos sobre homeostase e regulação das células que participam do turnover ósseo em fêmeas ainda são pouco compreendidos. Este trabalho teve como principal objetivo avaliar a participação de andrógenos na diferenciação e atividade de osteoclastos in vitro. Células totais de medula óssea de fêmur e tíbia de camundongos fêmeas foram utilizadas como fonte de células precursoras de osteoclastos, sendo cultivadas utilizando-se α-MEM suplementa

APA, Harvard, Vancouver, ISO, and other styles

28

Monteil, Christelle. "Modulation du phénotype exprimé par des cellules tubulaires proximales rénales en culture : stratégie pour le développement de modèles d'études in vitro en physiopathologie et pharmacotoxicologie rénales." Rouen, 1994. http://www.theses.fr/1994ROUES060.

Full text

Abstract:

Un modèle de culture primaire de cellules tubulaires proximales de rein de lapin est développé à partir de fragments calibrés de tubules proximaux cultivés sans sérum dans un environnement cellulaire variable. Un milieu dépourvu d'insuline et de glucose conduit à une réduction de l'activité glycolytique, principale altération du métabolisme des hydrates de carbone observée dans les cellules en culture. L'absence d'insuline et de glucose permet également de maintenir une distribution subcellulaire de la phosphoénolpyruvate carboxykinase, comparable à celle trouvée dans la suspension de tubules

APA, Harvard, Vancouver, ISO, and other styles

29

Khaghani, Seyed Ali. "Cell and tissue engineering of articular cartilage via regulation and alignment of primary chondrocyte using manipulated transforming growth factors and ECM proteins : effect of transforming growth factor-beta (TGF-β1, 2 and 3) on the biological regulation and wound repair of chondrocyte monolayers with and without presence of ECM proteins". Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/5371.

Full text

Abstract:

Articular cartilage is an avascular and flexible connective tissue found in joints. It produces a cushioning effect at the joints and provides low friction to protect the ends of the bones from wear and tear/damage. It has poor repair capacity and any injury can result pain and loss of mobility. One of the common forms of articular cartilage disease which has a huge impact on patient's life is arthritis. Research on cartilage cell/tissue engineering will help patients to improve their physical activity by replacing or treating the diseased/damaged cartilage tissue. Cartilage cell, called chond

APA, Harvard, Vancouver, ISO, and other styles

30

Udo, Mariana Sayuri Berto. "Caracterização da via de ativação de neurotoxicidade induzida pela Anidroegconina Metil Éster (AEME) in vitro." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-22012018-103721/.

Full text

Abstract:

O consumo mundial de cocaína vem crescendo e no Brasil já são estimados mais de 2 milhões de usuários, destes 370 mil usam regularmente o crack. A cocaína, em suas diversas formas, é um psicoestimulante com alto potencial de abuso e a forma fumada causa à seus usuários mais complicações de saúde do que as demais formas. Muitas dessas complicações estão relacionadas às funções cognitivas, como comprometimento da atenção e memória. O usuário de crack, no ato de fumar, está sujeito tanto à ação da cocaína volatilizada quanto a dos seus produtos de pirólise, principalmente da anidroecgnonina metil

APA, Harvard, Vancouver, ISO, and other styles

31

Franke, Jana, Vanessa Abs, Claudia Zizzadoro, and Getu Abraham. "Comparative study of the effects of fetal bovine serum versus horse serum on growth and differentiation of primary equine bronchial fibroblasts." Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-144893.

Full text

Abstract:

Background: Airway fibroblasts have become a critical addition to all facets of structural lung tissue changes such as in human asthma and chronic obstructive pulmonary disease, but little is known about their role in the equine recurrent airway obstruction, a disease that resembles to the human asthma. Since the equine bronchial fibroblasts (EBF) have not been isolated and characterized yet, the use of defined medium was investigated. Results: Primary EBF were cultured on non-collagen coated flasks without serum or in the presence of feta bovine serum (FBS) or horse serum (HS) or in serum dep

APA, Harvard, Vancouver, ISO, and other styles

32

Wölffling, Sarah. "Generation of a stem cell driven in vitro culture of polarized cells to study gastric tissue homeostasis and response to infections." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/21716.

Full text

Abstract:

In der humanen Magenschleimhaut regulieren eine Vielzahl von Interaktionen zwischen verschiedenen Zellpopulationen die Verdauung und die Überwachung von Infektionen. Epithelzellen in der Schleimhaut differenzieren in spezialisierte Zelltypen, die schützenden Mukus, Magensäure, Verdauungsenzyme oder Hormone produzieren. Eine Infektion mit Helicobacter pylori kann die Gewebehomöostase fehlregulieren, was die Wahrscheinlichkeit erhöht, dass an der Infektionsstelle ein Magengeschwür, ein Adenokarzinom oder letztendlich Magenkrebs auftritt. In dieser Arbeit wird die Entwicklung eines neuartigen in

APA, Harvard, Vancouver, ISO, and other styles

33

Grasso, Sonia. "Effect of growth factors, steroids, alfa-lipoic acid and Astroglial Conditioned Media on the expression of some biomarkers of astroglial cell proliferation and differentiation in primary culture." Doctoral thesis, Università di Catania, 2013. http://hdl.handle.net/10761/1323.

Full text

Abstract:

Several studies shown that the growth factors involved on astroglia, and also promote the accretion of neuritis.Furthermore, it is known in the literature that the astroglia proliferation is closely related to cell growth In addition, steroid hormones play a key role on the function and development of the brain in mammals. In fact, they adjust the neuroendocrine function with type mechanisms feedback to the hypothalamic-pituitary level and they are also implicated in the control of cognitive and motor function in the control of mental status through the regulation of neurotransmission aminer

APA, Harvard, Vancouver, ISO, and other styles

34

Brodlie, Malcolm James. "Development of a primary airway epithelial cell culture model and explanted tissue archive to study the role of neutrophilic inflammation and airway remodelling in cystic fibrosis lung disease." Thesis, University of Newcastle Upon Tyne, 2011. http://hdl.handle.net/10443/1228.

Full text

Abstract:

Cystic fibrosis (CF) is the most common inherited life-limiting condition in the United Kingdom. Lung disease, involving retention of mucopurulent secretions, neutrophilic inflammation and endobronchial infection is the major cause of mortality. CF is caused by variants in the CF-transmembrane conductance regulator gene, however the exact pathogenesis of lung disease is not fully understood. Valid experimental models are therefore critical to advance research. I describe the establishment of a successful method to culture primary bronchial epithelial cells (PBECs) from explanted CF lungs remov

APA, Harvard, Vancouver, ISO, and other styles

35

Cardoso, Matheus Völz. "Efeitos da fotobioestimulação por laser e LED nas células da granulação óssea." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/25/25146/tde-28092017-193857/.

Full text

Abstract:

A fotobioestimulação por laser e LED é uma tendência terapêutica inovadora e não invasiva. Os efeitos fotofísicos e fotoquímicos dessa terapia geram imunomodulação, aceleram a cicatrização e angiogênese, bem como reduzem a dor. Dessa forma tem se buscado o emprego desses estímulos no tecido ósseo, porém ainda inexistem padrões definidos para obter a melhor fotobioestimulação nas células ósseas. O objetivo desse trabalho foi avaliar a capacidade da fotobioestimulação na viabilidade celular e mineralização de células da granulação óssea de ratos (rGO). Células rGO na 6ª passagem foram plaqueadas

APA, Harvard, Vancouver, ISO, and other styles

36

Hall-Ponselè, Andrew M. "Genetic engineering of the primary/secondary metabolic interface in tobacco BY-2 cells." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:be5a3ee3-33c7-455c-b043-409987395f98.

Full text

Abstract:

The supply of precursors from primary metabolism is often overlooked when engineering secondary metabolism for increased product yields. This is because precursor supply may be assumed to be non-limiting, and it is considered difficult to engineer primary metabolism, because control of carbon flow (flux) is generally distributed among most enzymes of the pathway. The aim of this thesis was to increase the production of sterols, part of the isoprenoid class of secondary metabolites, in tobacco (Nicotiana tabacum) Bright Yellow 2 (BY-2) cell cultures. This was achieved by genetically engineering

APA, Harvard, Vancouver, ISO, and other styles

37

Ha, Thi Binh Minh. "Contributions à l'étude des méthodes de production de masse des cellules endothéliales cornéennes humaines." Thesis, Saint-Etienne, 2014. http://www.theses.fr/2014STET001T/document.

Full text

Abstract:

La bioingénierie de greffons endothéliaux cornéens est une des solutions réalistes en cours de développement dans quelques laboratoires pour palier au grand déséquilibre entre pénurie mondiale de dons de cornée et besoins immenses et croissant des populations. Cette véritable médecine régénérative consistera à injecter des cellules endothéliales (CEs) dans la chambre antérieure aux stades précoces des dystrophies endothéliales et, pour les stades avancées des pathologies endothéliales, à reconstruire in vitro des greffons endothéliaux composés d'un support transparent et biocompatible colonisé

APA, Harvard, Vancouver, ISO, and other styles

38

Negoescu, Adrien Nicolas. "Apoptose et évolution phénotypique des cellules corticosurrénaliennes en culture primaire." Grenoble 1, 1995. http://www.theses.fr/1995GRE10010.

Full text

Abstract:

Le cortex surrenal est une glande divisee en zones distinctes du point de vue morphologique et fonctionnel. Il est etabli que les divisions cellulaires des adrenocytes se produisent dans la couche superficielle (zones glomerulee et transitionnelle) et que ces cellules peripheriques migrent de maniere centripete. Chemin faisant, elles acquierent un phenotype different, propre aux zones fasciculee et reticulee. Enfin, l'elimination cellulaire, fortement amplifiee chez l'animal deprive en acth, se fait par apoptose dans la reticulee profonde. Le but de notre etude a ete de suivre l'evolution phen

APA, Harvard, Vancouver, ISO, and other styles

39

Canivet, Ludivine. "Caractérisation et toxicité de nanoparticules manufacturées de fer chez Physcomitrella patens (Hedw. Bruch & Schimp.) et sur cellules épithéliales bronchiques humaines (HBEC) : vers une utilisation en biosurveillance d’aérocontaminants nanoparticulaires." Thesis, Lille 2, 2013. http://www.theses.fr/2013LIL2S042/document.

Full text

Abstract:

De nombreux sites industriels émettent, non-intentionnellement, depuis des années des particules ultra-fines dans l’air. De nombreuses questions se posent sur leurs effets sur les écosystèmes et la santé humaine. Dans ce contexte, nous avons axé nos recherches autour de nanoparticules de fer manufacturées (Fe-NP), représentatives de celles que l’on retrouve dans les fumées des industries métallurgiques dunkerquoises et nous avons mené en parallèle des études d’écotoxicité et de toxicité. L’objectif principal de ces recherches était d’étudier l’impact de Fe-NP manufacturées exposées par voie aé

APA, Harvard, Vancouver, ISO, and other styles

40

Dias, Gisele Cristiane de Melo. "Caracterização, isolamento e cultura de espermatogônias primárias de curimbatá, Prochilodus lineatus (Valencienes, 1847)." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-08062015-100249/.

Full text

Abstract:

Machos adultos de P. lineatus tiveram suas gônadas processadas de acordo com as rotinas de microscopia de luz e microscopia eletrônica de transmissão. Para a cultura de células, os testículos foram digeridos enzimaticamente, a suspensão testicular foi separada por gradiente descontínuo com Percoll seguido pelo plaqueamento diferencial por adesão e as células foram cultivadas. Foi realizado o método de enriquecimento das espermatogônias por citometria de fluxo. Os testículos apresentam as regiões anterior, média e posterior com distribuição semelhante dos tipos de células, e o diâmetro nuclear

APA, Harvard, Vancouver, ISO, and other styles

41

String, Andreas Sebastian. "Immunhistochemische Vergleichsanalyse von Primärzellaggregaten und Ursprungsgeweben unterschiedlicher Dignität zur Charakterisirung der in-vitro Anpassung." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2002. http://dx.doi.org/10.18452/14758.

Full text

Abstract:

Immunhistochemische Vergleichsanalyse von Primärzellaggregaten und Ursprungsgeweben unterschiedlicher Dignität zur Charakterisierung der in-vitro Anpassung Zielsetzung: Dreidimensionale Zellkulturen stellen eine Weiterentwicklung der einschichtigen Zellkultur dar, die den in-vitro Bedingungen im Organismus näherkommt. Darüber hinaus ermöglichen organoide Kulturen, die neben der vorherrschenden Tumorzelle auch Bindegewebszellen und Immunzellen enthalten, eine Analyse der Interaktion dieser Zellen bei wichtigen Aspekten der Krebserkrankung wie Metastasierung, Angiogenese oder der Tumorimmunolog

APA, Harvard, Vancouver, ISO, and other styles

42

Triner, Joceline Clare. "Defining neurochemical properties and functions of primary sensory neurons in the rat trigeminal ganglion." Thesis, University of Plymouth, 2013. http://hdl.handle.net/10026.1/1585.

Full text

Abstract:

The trigeminal ganglion (TG) is a complex sensory structure and multiple lines of evidence suggest that significant differences exist in anatomical, neurochemical and physiological properties between it and its equivalent structure in the somatosensory system, the dorsal root ganglion (DRG). This is likely to be a reflection, first on the unique areas of tissue innervation of the TG and second, on the unusual responses to injury which give rise to distinct pain symptoms such as toothache, migraine and temporomandibular joint disorders. In an attempt to address this disparity in knowledge, we h

APA, Harvard, Vancouver, ISO, and other styles

43

Bonicelli, Jana. "In-vitro-Untersuchungen zu antifibrotischen Wirkungen von β-Adrenozeptoragonisten und Glucocorticoiden in primären equinen Bronchialfibroblasten". Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-189393.

Full text

Abstract:

Einleitung: Die Pathogenese chronisch entzündlicher Atemwegserkrankungen ist mit zunehmender Schädigung und fibrotischen Umbauvorgängen und daraus resultierenden Einschränkungen physiologischer Funktionen verbunden. Bei der Recurrent Airway Obstruction (RAO) des Pferdes sind solche strukturellen Veränderungen häufig assoziiert mit Verdickung der Atemwegswand, subepithelialer Fibrose und Obstruktion der Atemwege. Bei RAO besteht die Standardtherapie darin, die Bronchokonstriktion mit β2-Agonisten und die Entzündung mit Glucocorticoiden aufzuhalten. In den letzten Jahrzehnten konnte jedoch gezei

APA, Harvard, Vancouver, ISO, and other styles

44

Silva, William Phillip Pereira da. "Cultura de células osteogênicas primárias a partir de osso de baixa densidade e análise do reparo ósseo periimplantar em ratas osteoporóticas em função da texturização de superfície por meio da oxidação por plasma eletrolítico /." Araçatuba, 2019. http://hdl.handle.net/11449/180686.

Full text

Abstract:

Orientador: Leonardo Perez Faverani<br>Coorientadora: Roberta Okamoto<br>Banca: Daniela Ponzoni<br>Banca: Ellen Cristina Gaetti Jardim<br>Resumo: O objetivo deste estudo foi avaliar um novo método de texturização por PEO com incorporação de Ca e P na superfície do Ti-6Al-4V em ossos de baixa densidade, por meio de avaliação in vitro, ex-in vivo e in vivo, em função de parâmetros topográficos e reparacionais. 57 ratas Wistar (Rattus novergicus), sendo 38 ratas com 6 meses de idade (Grupos OXV - submetidas à ovariectomia e SHAM - cirurgia fictícia) e 19 ratas senis (18 meses de idade: Grupo SENI

APA, Harvard, Vancouver, ISO, and other styles

45

Penna, Vanessa [UNIFESP]. "Alteração da expressão gênica das vias de sinalização TGFβ/BMP, matriz extracelular e moléculas de adesão decorrente da passagem celular em cultura primária de hDPSC". Universidade Federal de São Paulo (UNIFESP), 2014. http://repositorio.unifesp.br/handle/11600/39274.

Full text

Abstract:

Submitted by Maria Anália Conceição (marianaliaconceicao@gmail.com) on 2016-06-23T11:30:40Z No. of bitstreams: 1 Publico-NOVO-03.pdf: 1761339 bytes, checksum: 1ec50dfc6d5850f1b16cf857655b8101 (MD5)<br>Approved for entry into archive by Maria Anália Conceição (marianaliaconceicao@gmail.com) on 2016-06-23T11:32:12Z (GMT) No. of bitstreams: 1 Publico-NOVO-03.pdf: 1761339 bytes, checksum: 1ec50dfc6d5850f1b16cf857655b8101 (MD5)<br>Made available in DSpace on 2016-06-23T11:32:12Z (GMT). No. of bitstreams: 1 Publico-NOVO-03.pdf: 1761339 bytes, checksum: 1ec50dfc6d5850f1b16cf857655b8101 (MD5) P

APA, Harvard, Vancouver, ISO, and other styles

46

Oster, Sandra. "Untersuchungen zur Dynamik und zum Aggregationsmechanismus von alpha-Synuklein in chronischen Toxinmodellen der dopaminergen Primärzellkultur." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-232129.

Full text

Abstract:

Ein Schlüsselbefund der Parkinson-Krankheit auf zellulärer Ebene ist das Auftreten von Protein-Einschlusskörperchen, sogenannten Lewykörperchen. Der Hauptbestandteil dieser Lewykörperchen ist pathologisch aggregiertes, fibrilläres α-Synuklein, ein Protein, welches Einfluss auf präsynaptische Vesikel, Protein- und Enzymfunktionen sowie den Dopaminstoffwechsel und den axonalen Transport hat. Bis heute ungeklärt ist die Ursache der Aggregation des Proteins. Zahlreiche Forschungsaktivitäten werden in diese Richtung unternommen. Die pathologischen Mechanismen, die zur abnormen Aggregation von α-Syn

APA, Harvard, Vancouver, ISO, and other styles

47

Mayaudon, Jean-Marie. "Nanostructuration de polymères d'implants neuronaux flexibles, caractérisation de leur biocompatibilité par une étude in-vitro, et conception d'un câble flexible pour l'enregistrement cortical de haute densité." Thesis, Université Grenoble Alpes, 2020. http://www.theses.fr/2020GRALS001.

Full text

Abstract:

La recherche en réhabilitation des fonctions motrices ou en exploration du cerveau par l’utilisation des neuroprothèses a deux enjeux majeurs adressés dans cette thèse : les implants doivent être de haute biocompatibilité sur le long terme et avec une haute densité d’électrodes. La littérature révèle que la nanostructuration de surface peut améliorer l’adhésion et le réseau des neurites de neurones et que les implants fins et souples, composés des polymères SU-8, polyimide ou parylène, réduisent la cicatrice gliale. Cette thèse montre qu’une gravure plasma (argon, oxygène) forme des nanofils (

APA, Harvard, Vancouver, ISO, and other styles

48

Chaves, Gabriela Pena. "Sistema canabinóide e seu possível papel em processos de neuroproteção e plasticidade: estudos in vivo e in vitro." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-03102008-113207/.

Full text

Abstract:

O sistema canabinóide parece participar de vários processos neurobiológicos, incluindo neuroproteção e plasticidade. Os objetivos deste estudo foram avaliar os efeitos de ablações retinianas sobre a expressão do receptor canabinóide CB1 e de proteínas estruturais no tecto óptico de pintos pelos métodos de imuno-histoquímica, immunoblotting e PCR em tempo real. Além disso, avaliamos os efeitos do tratamento com agonistas e antagonistas canabinóides em culturas de células do tecto óptico expostas ao NMDA por citometria de fluxo e quanto à morfologia. A ablação retiniana parece gerar um aumento d

APA, Harvard, Vancouver, ISO, and other styles

49

Martínez, Romero Carles. "Polycomb group proteins Bmi1 and Ring1B are involved in cell plasticity and tumorigenesis of the pancreas." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7190.

Full text

Abstract:

L'adenocarcinoma ductal pancreàtic (PDAC) és un dels càncers més letals. Per tal de millorar el diagnòstic precoç, s'estan investigant les etapes inicials de la formació del càncer, com és el cas de les lesions preneoplàstiques, i es vol desxifrar l'origen cel·lular de la malaltia. Les proteïnes Polycomb constitueixen una família de silenciadors epigenètics que es troben en una varietat de tumors sòlids. La hipòtesi principal és que Polycomb pot estar participant en els processos preneoplàstics del pàncreas i en l'aparició i progressió del tumor. La expressió de Bmi1 i Ring1B fou analitzada du

APA, Harvard, Vancouver, ISO, and other styles

50

Moraes, Luis Henrique Rapucci 1983. "Tratamento in vivo e in vitro com a associação de n-ateilcisteina e deferoxamina em camundongos distróficos." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317503.

Full text

Abstract:

Orientador: Elaine Minatel<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-24T19:48:05Z (GMT). No. of bitstreams: 1 Moraes_LuisHenriqueRapucci_D.pdf: 3874036 bytes, checksum: 7d72faf59790ed5f085eb2edd9aba075 (MD5) Previous issue date: 2014<br>Resumo: Devido ao fato dos camundongos mdx, modelo experimental da distrofia muscular de Duchenne, apresentarem peroxidação lipídica da membrana causada pelo aumento da produção espécies reativas de oxigênio (EROs) no período que antecede o início da degeneração das fibras musculares,

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!