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Relevant bibliographies by topics / Primary ectocervix epithelium

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Academic literature on the topic 'Primary ectocervix epithelium'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

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Journal articles on the topic "Primary ectocervix epithelium"

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Edwards, Jennifer L., Jian Q. Shao, Kevin A. Ault, and Michael A. Apicella. "Neisseria gonorrhoeae Elicits Membrane Ruffling and Cytoskeletal Rearrangements upon Infection of Primary Human Endocervical and Ectocervical Cells." Infection and Immunity 68, no. 9 (2000): 5354–63. http://dx.doi.org/10.1128/iai.68.9.5354-5363.2000.

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ABSTRACT Neisseria gonorrhoeae is a strict human pathogen that is, primarily, transmitted by close sexual contact with an infected individual. Gonococcal infection of the male urogenital tract has been well studied in experimental human models and in urethral cell culture systems. Recent studies, using tissue culture cell systems, have suggested a role for the cervical epithelium in gonococcal infection of females; however, the nature of gonococcal infection of the normal uterine cervix remains controversial. To address this enigma, we have developed two primary human cervical epithelial cell

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Schichl, Konstanze, and John Doorbar. "Regulation and Deregulation of Viral Gene Expression During High-Risk HPV Infection." Viruses 17, no. 7 (2025): 937. https://doi.org/10.3390/v17070937.

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Cervical cancer remains a global health burden, with persistent infection by high-risk human papillomaviruses (HR-HPVs) being the primary etiological factor. HR-HPVs target stem-like cells of the cervical epithelium to establish chronic infections. Upon infection of the cervical transformation zone (TZ)—a region adjacent to the squamocolumnar junction (SCJ)—these viruses drive neoplastic transformation, which is due in part to the unique cellular composition and hormonal responsiveness of the TZ. Reserve cells, which can accumulate at the cervical crypt entrances of the TZ, are thought to be h

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3

Sharkey, D. J., та S. A. Robertson. "229.Seminal plasma TGFβ activates pro-inflammatory cytokine synthesis in human cervical epithelial cells". Reproduction, Fertility and Development 16, № 9 (2004): 229. http://dx.doi.org/10.1071/srb04abs229.

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Exposure to semen at intercourse in women elicits an inflammation-like response characterised by recruitment of inflammatory cells and expression of pro-inflammatory cytokines including GM-CSF, interleukin-6 (IL-6) and IL-8 (1). Studies in animal models have implicated TGFβ as the major active moiety in seminal plasma, and we have shown previously that TGFβ1 and TGFβ3 are present in high concentrations in human seminal plasma (>100 ng/mL), while TGFβ2 is less abundant. To investigate the physiological significance of each of the three TGFβ isoforms as pro-inflammatory agents in human semina

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Franzén Boger, Mathias, Vilde Kaldhusdal, Anna Pascual-Reguant, et al. "Spatial transcriptomics and in situ immune cell profiling of the host ectocervical landscape of HIV infected Kenyan sex working women." Frontiers in Immunology 15 (December 2, 2024). https://doi.org/10.3389/fimmu.2024.1483346.

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IntroductionChronic immune activation is a hallmark of human immunodeficiency virus (HIV) infection that significantly impacts disease pathogenesis. However, in-depth studies characterizing the immunological landscape of the ectocervix during chronic HIV infection remain scarce despite the importance of this tissue site for HIV transmission.MethodsEctocervical tissue samples were obtained from antiretroviral-naïve HIV-seropositive and -seronegative Kenyan female sex workers. These samples were assessed by spatial transcriptomics and Gene Set Enrichment Analysis. We further performed multi-epit

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Tang, Chongfa, Chang Liu, Benoit Maffei, et al. "Primary ectocervical epithelial cells display lower permissivity to Chlamydia trachomatis than HeLa cells and a globally higher pro-inflammatory profile." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-85123-7.

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AbstractThe tumoral origin and extensive passaging of HeLa cells, a most commonly used cervical epithelial cell line, raise concerns on their suitability to study the cell responses to infection. The present study was designed to isolate primary epithelial cells from human ectocervix explants and characterize their susceptibility to C. trachomatis infection. We achieved a high purity of isolation, assessed by the expression of E-cadherin and cytokeratin 14. The infectious progeny in these primary epithelial cells was lower than in HeLa cells. We showed that the difference in culture medium, an

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Dissertations / Theses on the topic "Primary ectocervix epithelium"

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Tang, Chongfa. "The inflammatory response of primary epithelial cells of the female genital tract to Chlamydia trachomatis infection, and its exacerbation by type-I interferon." Electronic Thesis or Diss., Sorbonne université, 2022. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2022SORUS121.pdf.

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Chlamydia trachomatis est une bactérie intracellulaire obligatoire, qui se développe principalement dans cellules épithéliales des muqueuses du tractus génital. Asymptomatiques dans la plupart des cas, les infections par ce pathogène peuvent entrainer des inflammations pelviennes. L’inflammation peut elle-même engendrer des fibroses et mener à une infertilité tubaire chez les femmes. Il est important d’étudier la réponse des cellules épithéliales, qui constituent la première ligne de défense contre l’infection par C. trachomatis, pour mieux comprendre ses manifestations pathologiques dans le t

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