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Dissertations / Theses on the topic 'Prion conversion'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

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1

Kirby, Louise. "In vitro conversion studies of the prion protein." Thesis, University of Reading, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408319.

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2

Sanghera, Narinder. "The interaction of the prion protein with lipid membranes and implications for prion conversion." Thesis, University of Warwick, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247140.

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3

Milhavet, Ollivier. "Conversion de la protéine du prion : approches thérapeutiques et fonctionnelles." Montpellier 2, 2000. http://www.theses.fr/2000MON20149.

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Les encephalopathies spongiformes transmissibles (est), encore appelees maladies a prions, sont un groupe d'affections neurodegeneratives dont les plus connues sont la maladie de creutzfeldt-jakob chez l'homme, et l'encephalopathie spongiforme bovine ou maladie de la vache folle chez l'animal. L'hypothese etiologique actuelle suggere que l'agent infectieux de ces affections est represente par une proteine appelee prp s c (pour forme scrapie de la proteine du prion). La prp s c correspond a une forme alteree d'une proteine normale appelee prp c (pour forme cellulaire de la proteine du prion) do

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4

Giachin, Gabriele. "Toward the Identification of the Structural Determinants of Prion Conversion." Doctoral thesis, SISSA, 2012. http://hdl.handle.net/20.500.11767/4504.

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The post-translational conversion of PrPC into the misfolded, pathogenic form PrPSc plays a key role in prion diseases or transmissible spongiform encephalopathies. These disorders are neurodegenerative maladies affecting both human and animals. One of the crucial questions in prion biology is the identification of the regions on PrPC that lead to the conversion process, whereby most alpha-helical motifs are replaced by betasheet secondary structures. In order to gain insights into the structural determinants involved in PrPSc formation we investigated the effect of HuPrPC point mutations link

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Tran, Thanh Hoa. "The non-octarepeat copper-binding site of the prion protein and its potential role in prion conversion." Doctoral thesis, SISSA, 2016. http://hdl.handle.net/20.500.11767/4870.

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Transmissible spongiform encephalopathy (TSE) or prion diseases are fatal neurodegenerative disorders caused by a change in conformation of the prion protein from the normal cellular form (PrPC) to a misfolded form (PrPSc). Prion protein has long been known as a copper binding protein. Although the functional implication of copper binding to PrP is not yet clear, it is believed that copper is an important cofactor in prion disease. Therefore, the aim of this work is to determine the potential role of copper in prion conversion. Copper can effectively bind to PrPC via histidine residues in the

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6

Gupta, Vandana [Verfasser], and Christiane [Akademischer Betreuer] Ritter. "Infectious Prion Strain Directed Conformational Conversion of Recombinant PrP / Vandana Gupta ; Betreuer: Christiane Ritter." Braunschweig : Technische Universität Braunschweig, 2013. http://d-nb.info/1175821691/34.

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7

Graham, James Fionnlagh. "An investigation into the subcellular localisation of co-factors that stimulate prion protein conversion." Thesis, University of Warwick, 2009. http://wrap.warwick.ac.uk/3649/.

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8

Laferrière, Florent. "Structure quaternaire de la protéine prion : infectiosité, capacité de conversion, et potentiel de transmission interspécifique." Paris 7, 2013. http://www.theses.fr/2013PA077021.

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Les prions sont les pathogènes responsables de désordres neurodégénératifs d'issue fatale chez l'homme et de nombreuses espèces de mammifères. Ces agents sont composés d'une forme mal repliée (PrPse) d'une protéine de l'hôte, la protéine prion (PrPc). Durant l'infection, la PrPc adopte une conformation identique à celle de la PrPs, conduisant à une accumulation d'agrégats de PrPsc dans le cerveau, responsables des désordres neurologiques. Différentes souches de prions peuvent être propagées chez une même espèce. Peu d'informations sont disponibles sur le rôle de l'agencement de la PrPsc sous f

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9

Rabbanian, S. "Defining and understanding the conversion, propagation and trafficking of PrPsc in a prion infected cellular system." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1317792/.

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Prion diseases are fatal neurodegenerative disorders associated with conformational conversion of normal cellular prion protein (PrPC) to an abnormal disease-associated conformer (PrPSc). The aim of this thesis was to investigate the earliest event in prion infection using a novel cell system. Specifically, it aimed to assess the timescale that PrPC is converted to PrPSc following exposure to RML prions and identify the initial cellular site of PrPSc formation and propagation. The cell biology of the initial events of cellular prion infection are poorly understood since newly formed cellular P

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10

Mai, Phuong Thao. "The potential role of copper binding sites in prion propagation." Doctoral thesis, SISSA, 2014. http://hdl.handle.net/20.500.11767/3905.

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Transmissible spongiform encephalopathies (TSEs) or prion diseases are caused by a post-translational conversion of the normal cellular form of the prion protein (PrPC) into the pathological and infectious isoform denoted as prion or PrPSc. PrPC has been shown as a high-affinity copper-binding protein, and to a lesser extent binding to other divalent cations through the octarepeat region (OR) and the non-OR copper binding sites located in the disordered N-terminal domain. Studies on the role of copper in promoting prion conversion and infectivity yielded controversial results. In this work, we

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11

Boerner, Susann. "Probing reaction conditions and cofactors of conformational prion protein changes underlying the autocatalytic self-propagation of different prion strains." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2014. http://dx.doi.org/10.18452/17003.

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Prionen sind das infektiöse Agens transmissibler spongiformer Enzephalopathien von Tieren und Menschen. Prionen bestehen hauptsächlich aus einer abnormal gefalteten und aggregierten Isoform des zellulären Prionproteins (PrP). Die Replikation von Prionen findet mutmaßlich durch keiminduzierte Polymerisation des Prionproteins statt. Es existieren verschiedene Prionstämme, die unterschiedliche Eigenschaften aufweisen, aber vom selben zellulären Prionprotein abstammen können. Neben PrP scheinen Kofaktormoleküle an der Prionreplikation beteiligt zu sein. Weiterhin wird angenommen, dass Kofaktoren b

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12

Foran, Frances. "Conversions : women re-signing from prison." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28270.

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The research examines the development of women's prison writing through the journal of the Kingston Prison for Women, Tightwire. The journal enabled the prisoners to articulate their experience of prison for themselves as a specific subject-group, as women and as legal subjects. The research connects the prison writing to alterations in legal discourse which reflect the emergence of women as a specific group. The prison writings suggest that extra-legal discourse transforms legal discourse and practice. The appendix includes a selection of poems and comments from Tightwire .

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Araújo, Fábio Firmino de. "Mercado de almas aflitas: crime, castigo e conversão religiosa." Universidade Federal da Paraíba, 2009. http://tede.biblioteca.ufpb.br:8080/handle/tede/7336.

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Made available in DSpace on 2015-05-14T13:27:13Z (GMT). No. of bitstreams: 1 parte1.pdf: 4931396 bytes, checksum: 257775c5c9416337e935654ee3e5137e (MD5) Previous issue date: 2009-03-30<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>This study concerns to a theoretical and field research to understand the symbolic and political strategies of religious conversion to evangelical churches in social subjects marked their stories of life in the practice, criminal careers and prospects. The social actors investigated here are prisoners of the Maximum Security Criminalis

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14

Rolston, Simon. "Narratives of conversion and coercion : American prison life writing since 1945." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/29635.

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In this dissertation, I consider the relationship between the rhetoric of conversion that informs the American prison system and the pervasive use of the conversion narrative in the life writing of American prisoners. I argue that ever since the first penitentiary opened its gates at the beginning of the nineteenth century, prison reformers have relied on the conversion narrative to redefine the rehabilitative goals of the modern prison. Prison reformers, moreover, have historically deployed a variety of strategies—indeterminate sentencing, the “mark system,” the parole board, and the prison f

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15

Goodwin, Louise. "Time for change : a study of religious conversion and self-identity in prison." Thesis, University of Sheffield, 2002. http://etheses.whiterose.ac.uk/14834/.

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This thesis provides a sociological analysis of religious conversion in prison. In depth-interviews were conducted in order to obtain accounts of prisoners' experiences and subjective perceptions of conversion. Four main research objectives are addressed. Firstly, questions about prisoners' identity are considered. Secondly, the social processes involved in religious conversion are analysed, paying particular attention to the meaning of religious conversion for prisoners. Thirdly, an analysis of the role of religion in the everyday lives of converts is provided. Lastly, the process of personal

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16

Thompson, Helen Nathalia. "Investigação computacional das doenças priônicas : influência dos campos de força e dos estados de protonação na conversão estrutural da proteína príon celular." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2018. http://hdl.handle.net/10183/184574.

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Príons são proteínas que causam um grupo de doenças neurodegenerativas invariavelmente fatais, sendo uma das mais conhecidas a encefalopatia espongiforme bovina (ou doença da vaca louca). A proteína príon celular (PrPc), rica em estrutura α-helicoidal, sofre uma mudança na sua estrutura secundária produzindo a proteína patológica (PrPSc; o príon) na qual prevalecem folhas-β. Devido à falta de dados estruturais de alta resolução dos príons, simulações de dinâmica molecular (DM) podem ser particularmente úteis para estudar o redobramento de PrP. Estudos experimentais e computacionais, descritos

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17

Pereira, Ana Beatriz de Vilhena. "“São os evangélicos que seguram essa cadeia, se não fossem eles, quem iria converter os mauzão?”: considerações sobre o papel do “proceder evangélico” na prisão." Universidade Federal de Juiz de Fora (UFJF), 2017. https://repositorio.ufjf.br/jspui/handle/ufjf/4653.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2017-05-25T13:56:14Z No. of bitstreams: 1 anabeatrizdevilhenapereira.pdf: 841053 bytes, checksum: 302aa25eb5d0b57be181040b33a32e6b (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2017-05-25T14:47:49Z (GMT) No. of bitstreams: 1 anabeatrizdevilhenapereira.pdf: 841053 bytes, checksum: 302aa25eb5d0b57be181040b33a32e6b (MD5)<br>Made available in DSpace on 2017-05-25T14:47:49Z (GMT). No. of bitstreams: 1 anabeatrizdevilhenapereira.pdf: 841053 bytes, checksum: 302aa25eb5d0b57be181040b33a32e6b (MD5)

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18

Smith, Katie S. "A profile of HOV lane vehicle characteristics on I-85 prior to HOV-to-HOT conversion." Thesis, Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/42923.

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The conversion of high-occupancy vehicle (HOV) lanes to high-occupancy toll (HOT) lanes is currently being implemented in metro Atlanta on a demonstration basis and is under consideration for more widespread adoption throughout the metro region. Further conversion of HOV lanes to HOT lanes is a major policy decision that depends on knowledge of the likely impacts, including the equity of the new HOT lane. Rather than estimating these impacts using modeling or surveys, this study collects revealed preference data in the form of observed vehicle license plate data and vehicle occupancy data fr

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19

Curran, Kathryn L. "Finding God behind bars : an exploratory study of the relevance of prison conversions to criminology." Thesis, University of Cambridge, 2002. https://www.repository.cam.ac.uk/handle/1810/272048.

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20

Iglesias, Mas Valentín. "Bioinformatic analysis on the determinants of protein aggregation and conformational conversion." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/673197.

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L’agregació de proteïnes ha passat de ser gairebé una curiositat biofísica sense major interès a un dels camps més actius de la recerca, especialment des que es va esbrinar que podia ser la causa de diverses malalties en humans. L’agregació en proteïnes ve determinada en un primer terme per la seva seqüència aminoacídica, que és qui delimita les possibles interaccions entre els seus aminoàcids. Diferents factors modulen aquesta propensió intrínseca a agregar. Sovint les proteïnes assoleixen un plegament natiu que és energèticament més estable i que usualment amaga regions propenses a agregar,

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21

Sarg, Rachel. "Incertitudes et croyances : approche sociologique des phénomènes d'adhésions et de réadhésions religieuses en prison." Paris 7, 2014. http://www.theses.fr/2014PA070036.

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Cette thèse a pour objet l'analyse du sens de l'adhésion à des croyances et à des pratiques religieuses dans l'expérience carcérale des détenus. A partir d'une approche cognitive basée sur l'individualisme méthodologique, il s'agit d'examiner trois dimensions spécifiques et transversales de cet objet d'étude. D'une part, la pratique d'une religion dans un contexte aussi spécifique que la prison interroge le degré d'autonomie des individus évoluant dans un milieu contraignant. D'autre part, il s'agit de comprendre la dynamique des croyances à travers l'interaction entre l'offre religieuse et l'

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22

Moraes, Paulo Augusto Costivelli e. "Saude mental e religião em mulheres encarceradas : um estudo epidemiologico e de Psiquiatria cultural." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311604.

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Orientador: Paulo Dalgalarrondo<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-06T23:25:25Z (GMT). No. of bitstreams: 1 Moraes_PauloAugustoCostivellie_M.pdf: 81784882 bytes, checksum: f16e045d8c51eae7735517cc074fd3f2 (MD5) Previous issue date: 2006<br>Resumo: A religião voltou a ser considerada uma questão importante para a sociedade contemporânea. Fenômeno bastante complexo é atualmente considerado um elemento extremamente significativo para a sua vida sócio-cultural. Atribui-se à religião um papel fundamen

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23

Alidières, Lucie. "Interactions et pratiques d'un processus d'innovation pédagogique en environnement carcéral." Phd thesis, Université Paul Valéry - Montpellier III, 2013. http://tel.archives-ouvertes.fr/tel-00873193.

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La recherche porte sur la formation universitaire à distance adaptée à des personnes détenues, dispositif qui se situe à l'intersection de plusieurs domaines d'activités, universitaire et carcérale. Cette étude vise à analyser plusieurs étapes d'un processus d'innovation pédagogique. Une première consiste à appréhender le terrain de la prison dans une démarche ethnographique constituée de pratiques d'accès aux activités de cours. Une seconde est conduite de façon à épouser les spécificités sociales et pédagogiques d'un tel terrain. Une troisième analyse les méthodes et les procédures de distri

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24

Rauniomaa, M. (Mirka). "Recovery through repetition:returning to prior talk and taking a stance in American-English and Finnish conversations." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514289248.

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Abstract The study examines ‘recovery through repetition’, investigating how speakers repeat their own utterances in order to return to prior talk. The phenomenon comprises instances of everyday, casual conversation in which speakers indicate that their utterance was either not taken up at all or not taken up to an adequate degree. By repeating the utterance more or less word-for-word, speakers suggest to their recipients that a (different type of) response is relevant and offer the utterance for re-consideration. The data consist of American-English and Finnish conversations. The segments com

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25

Oliveira, Luana Maria Lyra Carreras Correa de. "Os filhos evang?licos do novo caldeir?o do diabo: a convers?o religiosa na penitenci?ria de alca?uz." Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13654.

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Made available in DSpace on 2014-12-17T14:20:06Z (GMT). No. of bitstreams: 1 LuanaMLCCO_DISSERT.pdf: 3630536 bytes, checksum: 5749d11d78f455826403884e9690ef04 (MD5) Previous issue date: 2012-07-06<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>The theme of the research is inserted at a field of intersection between the Sociology of Religion and Sociology of Violence, having as the general objective study the sociological meaning of the conversion of prisoners that lives at the biggest prison (Prison of Alca?uz) of Rio Grande do Norte to the evangelical churches. The resear

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26

Iermolovych, Ganna. "Multifunkční kulturní centrum "Creative City" Brno." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2015. http://www.nusl.cz/ntk/nusl-394005.

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The master degree project presents design of conversion and extension of an old former prison situated between the streets Cejl, Soundni and Bratislavska for cultural, commercial and manufacturing purposes and forming multifunctional cultural center. The proposal consists of the conversion of two floors of existing building on the street Soudni, demolition of additional building on the street Bratislavska, while the additional building on street Cejl is belonging to other owner and will remain in existing status. Before the new building it is created a small square, that connects new and old b

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Huang, Mei-Yu, and 黃玫毓. "The Effect of Octapeptide on Prion Fibril Conversion." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/49342058306938104576.

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碩士<br>國立中正大學<br>分子生物研究所<br>103<br>Prion diseases are neurodegenerative disorders carried out in mammalian. These diseases are due to structural conversion of prion protein (PrP) from normal cellular isoform (PrPC) to pathogenic isoform (PrPSc). PrPC is most of α-helical with soluble and protease sensitive. After conversion to PrPSc, protein is β-sheet rich and become insoluble and protease-resistant. According to previous studies, the C-terminal region of prion protein, PrP121-230, is the toxic component to from PrPSc and can be against protease K digestion. Therefore, the flexible N-terminal

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Jheng, Cheng-Ping, and 鄭承平. "The Participation of Prion N-terminal Fragments in Fibril Conversion." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/94266627842178784537.

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碩士<br>國立中正大學<br>分子生物研究所<br>103<br>Transmissible spongiform encephalopathy (TSE) belongs to fetal neurodegenerative diseases. The disease is infected by the pathogen called PrPSc, a robustly beta-sheet-riched isoform of cellular prion protein (PrPC). The accumulation of PrPSc forms amyloid plaque resulting in the loss of neuron. Different from other neurodegenerative diseases, prion disease can spread between species by PrPSc. In the past years, the amyloidogenic region of C-terminal prion protein is believed to be the major domain carring of proteinase-resistance resulting in the occurrence of

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29

Lin, Jiayu, and 林家瑜. "Divergence and conversion of strains of the yeast prion [PSI+]." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/34681364204433556158.

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博士<br>國防醫學院<br>生命科學研究所<br>100<br>Immense diversity of prion strains is observed, but its underlying mechanism is less clear. Three [PSI] prion strains—named VH, VK, and VL—were previously isolated in the wild-type yeast genetic background. Here we report the generation and characterization of eight new [PSI] isolates, obtained by propagating the wild-type strains with Sup35 proteins containing single amino-acid alterations. The VH strain splits into two distinct strains when propagated in each of the three genetic backgrounds, harboring respectively single mutations of N21L, R28P, and Gi47 (i.

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30

Yang, Che, та 楊哲. "Exploring the α-to-β structural conversion mechanism for mouse prion protein". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/45088050163102612844.

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碩士<br>國立臺灣大學<br>生化科學研究所<br>101<br>Prion diseases are not only fetal but also infectious neurodegenerative disorders. The critical molecular event of prion diseases is the structural conversion of a normal cellular prion protein, PrPC, into a misfolded, infectious form, PrPSc. The overall structure of the prion protein transits from α- to β-dominant state, giving rise to formation of toxic amyloid fibrils. Up to now, the structural transition mechanism is still elusive. Recently, our lab found that disulfide-bond reduced mouse prion protein could be fixed in α-helical or β-rich structure under

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Luo, Wei-Lin, та 羅瑋霖. "Exploring the role of three α-helices on the structural conversion of mouse prion protein". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/34783584911984818565.

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碩士<br>國立臺灣大學<br>生化科學研究所<br>100<br>Transmissible Spongiform Encephalopathies (TSE), also called prion diseases are infectious neurodegenerative disorders. The key molecular event in the pathogenesis of prion diseases is the conformational conversion of a cellular prion protein, PrPC, into a misfolded form, PrPSc. The α to β conformational transition leads to protein aggregation and the formation of toxic amyloid fibrils. However, the mechanism of protein misfolding and the pathogenic pathway are still unclear. In our lab’s previous study, we found that the disulfide-deleted mouse PrP could

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32

Cramm, Maria. "Untersuchungen zu den selbst-replizierenden Eigenschaften des pathogenen Prion-Proteins beim Menschen." Doctoral thesis, 2016. http://hdl.handle.net/11858/00-1735-0000-0028-86BD-3.

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Prionkrankheiten sind übertragbare, tödliche neurodegenerative Erkrankungen beim Menschen und bei Tieren. Sie basieren auf der Konversion des zellulären Prion-Proteins (PrPC) in seine pathogene Form (PrPSc). Durch diese Konversion sind Prionkrankheiten pathogen und übertragbar. Bis heute ist weder der dem zugrunde liegende Mechanismus verstanden noch eine Behandlung gefunden worden. Die sichere Diagnose einer sporadischen Prionkrankheit ist ausschließlich mittels Gehirnbiopsie möglich, weswegen zu Lebzeiten des Patienten häufig nur die Diagnose einer wahrscheinlichen Prionkrankheit erfolgt. Zu

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Elmallah, Mohammed Ismail Youssef [Verfasser]. "Analysis of the molecular basis of the conversion and aggregation of prion proteins induced by oxidative stress / vorgelegt von Mohammed Ismail Youssef Elmallah." 2010. http://d-nb.info/1010317598/34.

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34

Blouin, Samuel. "La conversion entre intimité et publicité : essai d'imagination sociologique." Thèse, 2014. http://hdl.handle.net/1866/11646.

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Avec ce mémoire, j’ai souhaité cerner ce qui serait le propre d’une conversion, soit ce que j’ai appelé un processus de trans-formation. Avec ce concept original, j’ai voulu orienter le regard de l’observateur vers les points de basculement de l’intimité à la publicité qui caractérisent les conversions. Pour ce faire, il m’est apparu fertile de mobiliser et de réhabiliter l’étude des valeurs, un thème classique en sociologie. Des valeurs portées par des individus aux valeurs publiques, la notion de « valeur » recèle le potentiel heuristique nécessaire pour étudier les conversions à différentes

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