Relevant bibliographies by topics / Privileged scaffold

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Privileged scaffold'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Privileged scaffold"

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Shinde, Rani A., Vasanti M. Suvarna, and Arundhati N. Abhyankar. "AN INSIGHT INTO PRIVILEGED SCAFFOLDS IN TUBERCULOSIS: DEVELOPMENTAL ASPECTS AND IMPLICATIONS IN DRUG DESIGN." Indian Drugs 59, no. 01 (2022): 7–22. http://dx.doi.org/10.53879/id.59.01.13140.

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Tuberculosis remains a major threat to mankind, becoming more deadly due to COVID-19 pandemic. The worldwide scenario is daunted by additional factors such as drug resistance, non-adherence and complexity of the treatment. To overcome these obstacles, there is a constant need for novel drug development. However, drug development is an extensive process in itself requiring enormous financial investment and is time-consuming with a low success rate. A viable alternative to circumvent these complications is to explore ‘privileged scaffold/s’. Further logical approaches would be to study the privi
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Tomassoli, Isabelle, and Daniela Gündisch. "Bispidine as a Privileged Scaffold." Current Topics in Medicinal Chemistry 16, no. 11 (2016): 1314–42. http://dx.doi.org/10.2174/1568026615666150915111434.

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N, Ramalakshmi, Amuthalakshmi S, Yamuna R, A. Smith Anton, and Arunkumar S. "Indolizine- A Privileged Biological Scaffold." Der Pharma Chemica 13, no. 2 (2021): 10. https://doi.org/10.5281/zenodo.14718468.

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Indolizine derivatives own cherished biological activities and have been studied for their hypoglycemic, antimicrobial, anti-inflammatory& analgesic, anti-tumour activities. Indolizine scaffold has fascinated speculation and continuing interest and has become an important parent system for the development of potent new drug candidates. The conjugated planar electronic structure exhibits strong fluorescence properties which serve as a valuable tool for DNA interaction and spectroscopic sensitizer studies. Thus, the chemistry, synthesis and properties of this merged system and its derivative
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Cesarini, Silvia, Ilaria Vicenti, Federica Poggialini, et al. "Serendipitous Identification of Azine Anticancer Agents Using a Privileged Scaffold Morphing Strategy." Molecules 29, no. 7 (2024): 1452. http://dx.doi.org/10.3390/molecules29071452.

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The use of privileged scaffolds as a starting point for the construction of libraries of bioactive compounds is a widely used strategy in drug discovery and development. Scaffold decoration, morphing and hopping are additional techniques that enable the modification of the chosen privileged framework and better explore the chemical space around it. In this study, two series of highly functionalized pyrimidine and pyridine derivatives were synthesized using a scaffold morphing approach consisting of triazine compounds obtained previously as antiviral agents. Newly synthesized azines were evalua
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Chaudhary, Ashu, and Anshul Singh. "NANOPARTICLES: PRIVILEGED SCAFFOLD FOR CANCER TREATMENT." International Journal of Advanced Research 4, no. 10 (2016): 1–10. http://dx.doi.org/10.21474/ijar01/2047.

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Saha, Debasmita, Garima Jain, and Anuj Sharma. "Benzothiazepines: chemistry of a privileged scaffold." RSC Advances 5, no. 86 (2015): 70619–39. http://dx.doi.org/10.1039/c5ra12422k.

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Benzothiazepines being an integral part of the major cardiovascular drugs in market ascertain their biological importance. This review presents a comprehensive vision of the various synthetic tactics adopted till now to afford these frameworks.
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Rakesh, K. P., C. S. Shantharam, M. B. Sridhara, H. M. Manukumar, and Hua-Li Qin. "Benzisoxazole: a privileged scaffold for medicinal chemistry." MedChemComm 8, no. 11 (2017): 2023–39. http://dx.doi.org/10.1039/c7md00449d.

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Roelfes, Gerard. "LmrR: A Privileged Scaffold for Artificial Metalloenzymes." Accounts of Chemical Research 52, no. 3 (2019): 545–56. http://dx.doi.org/10.1021/acs.accounts.9b00004.

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Chao, Bo, Bingbing X. Li, and Xiangshu Xiao. "The chemistry and pharmacology of privileged pyrroloquinazolines." MedChemComm 6, no. 4 (2015): 510–20. http://dx.doi.org/10.1039/c4md00485j.

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Xiong, Donglu, Wenxi Zhou, Zhiwu Lu, Suping Zeng, and Jun (Joelle) Wang. "A highly enantioselective access to chiral chromanones and thiochromanones via copper-catalyzed asymmetric conjugated reduction of chromones and thiochromones." Chemical Communications 53, no. 51 (2017): 6844–47. http://dx.doi.org/10.1039/c7cc03939e.

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Dissertations / Theses on the topic "Privileged scaffold"

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Dziwornu, Godwin Akpeko. "Isolation and characterization of African marine natural products and repositioning of the natural product antibiotic fusidic acid and privileged benzimidazole scaffold for tuberculosis and malaria." Doctoral thesis, Faculty of Science, 2019. http://hdl.handle.net/11427/30358.

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Many bioactive compounds isolated from nature (microbes, plants and animals) are successfully being used as drugs to prevent and/or cure diseases. A greater number of these natural products have not progressed to the latter stages of development as drugs largely due to the drawbacks of toxicity, limited supply, growing concerns to conserve terrestrial and marine ecosystems and their biodiversity, which impedes sample collections in adequate quantities for research, among others. However, in spite of these drawbacks, the medicinal chemistry explorations of bioactive natural products, which hith
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Moulin, Emilie. "Diversity-oriented synthesis of pochonins : a privilege scaffold for ATPase and kinase inhibition." Université Louis Pasteur (Strasbourg) (1971-2008), 2006. https://publication-theses.unistra.fr/public/theses_doctorat/2006/MOULIN_Emilie_2006.pdf.

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Les pochonines A-F sont six molécules récemment décrites appartenant à la famille des lactones résorcyliques à 14 chaînons et qui présentent une activité contre le virus de l’herpès. Notre intérêt initial pour ces dérivés était fondé sur l’observation que plusieurs autres lactones résorcyliques sont connues pour leur potentiel biologique comme inhibiteurs de kinases ou d’ATPases. Par ailleurs le radicicol, de structure proche, est un puissant inhibiteur de la protéine de choc thermique HSP90, cible privilégiée pour la chimiothérapie en raison de son rôle fondamental dans la maturation fonction
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Khan, Raysa. "Late-stage C-H & N-H functionalisation of Benzodiazepines and other privileged scaffolds." Thesis, University of Sussex, 2018. http://sro.sussex.ac.uk/id/eprint/79061/.

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This thesis focuses on developing efficient, atom-economic synthesis routes for functionalised 5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one libraries. 1,4-Benzodiazepines (BZDs) are often referred to as “privileged scaffolds” due to their important biological activities; therefore, finding new efficient methods for synthesising such analogues is highly desirable in pharmaceutical and medicinal research. Chapter 1 introduces the project detailing the biological importance and applications of BZDs. The classical synthetic routes towards BZDs and some of the limitations for efficient and rapid
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Lucidi, Alessia. "The quinazoline ring as privileged scaffold in epigenetic medicinal chemistry." Doctoral thesis, 2017. http://hdl.handle.net/11573/1042729.

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Our investigation of quinazolines as H3K9 methyltransferase/demethylase or DNMT inhibitors led us to identify MC3774, a Lys-mimicking derivative displaying dual G9a methyltransferase/LSD1 inhibition. In particular, MC3774 showed IC50 values of 1205 nM and 440 nM on G9a and LSD1 respectively. In MV4-11 leukemia cells, MC3774 displayed antiproliferative activity with IC50=894 nM. The most interesting aspect of this investigation is about the inhibition mechanism. We designed MC3774 supposing that the insertion of the propaneamine moiety could mimic the H3K4me2 moiety of the substrate bound withi
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Books on the topic "Privileged scaffold"

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Bräse, Stefan, ed. Privileged Scaffolds in Medicinal Chemistry. Royal Society of Chemistry, 2015. http://dx.doi.org/10.1039/9781782622246.

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Ameta, K. L., and Khan Shahnawaz. β-Carbolines: A Privileged Scaffold for Modern Drug Discovery. Taylor & Francis Group, 2022.

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Ameta, K. L., and Khan Shahnawaz. β-Carbolines: A Privileged Scaffold for Modern Drug Discovery. Taylor & Francis Group, 2019.

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Ameta, K. L., and Khan Shahnawaz. β-Carbolines: A Privileged Scaffold for Modern Drug Discovery. Taylor & Francis Group, 2019.

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Ameta, K. L., and Khan Shahnawaz. β-Carbolines: A Privileged Scaffold for Modern Drug Discovery. Taylor & Francis Group, 2019.

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Ameta, K. L., and Khan Shahnawaz. β-Carbolines: A Privileged Scaffold for Modern Drug Discovery. Taylor & Francis Group, 2019.

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7

Fu, Caiyun, Bin Yu, and Ning Li. Privileged Scaffolds in Drug Discovery. Elsevier Science & Technology Books, 2023.

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Privileged Scaffolds in Drug Discovery. Elsevier Science & Technology, 2023.

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9

Martinez, Ana, Roland Pfau, Stefan Bräse, David Thurston, and Dorota Jakubczyk. Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation. Royal Society of Chemistry, The, 2015.

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Bräse, Stefan. Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation. Royal Society of Chemistry, The, 2015.

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Book chapters on the topic "Privileged scaffold"

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Prabhakar, Yenamandra S., V. Raja Solomon, Manish K. Gupta, and S. B. Katti. "Erratum to QSAR Studies on Thiazolidines: A Biologically Privileged Scaffold." In Topics in Heterocyclic Chemistry. Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/7081_045.

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Marquez, Victor E. "Privileged Drug Scaffolds." In The Ups and Downs in Drug Design. CRC Press, 2021. http://dx.doi.org/10.1201/9781003203506-4.

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Chen, Xingyu, Runyu Miao, Leihao Zhang, Zhen Yuan, Honglin Li, and Shiliang Li. "Computational methods for scaffold hopping." In Privileged Scaffolds in Drug Discovery. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-443-18611-0.00008-5.

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Alam, Mohammad Abrar. "Thiazole, a privileged scaffold in drug discovery." In Privileged Scaffolds in Drug Discovery. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-443-18611-0.00027-9.

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Chen, Xin. "Tetrahydro-β-carboline scaffold in drug discovery." In Privileged Scaffolds in Drug Discovery. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-443-18611-0.00009-7.

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Peng, Xinyan, Qiushi Chen, Bo Han, Hao Zhang, Jianqi Li, and Qingwei Zhang. "Applications of piperazine scaffold in drug design." In Privileged Scaffolds in Drug Discovery. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-443-18611-0.00018-8.

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Chang, Yingjie, Xuben Hou, and Hao Fang. "Cyanopyridine as a privileged scaffold in drug discovery." In Privileged Scaffolds in Drug Discovery. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-443-18611-0.00021-8.

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Cui, Sunliang. "Indazole as a privileged scaffold in drug discovery." In Privileged Scaffolds in Drug Discovery. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-443-18611-0.00034-6.

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Chen, Cheng, Dongmei Wang, and Ke-Wu Yang. "Thiols as a privileged scaffold against metallo-β-lactamases." In Privileged Scaffolds in Drug Discovery. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-443-18611-0.00036-x.

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Lu, Yunlong, Wan Zhang, Jing Shi, Yawen Wang, and Wukun Liu. "N-Heterocyclic carbene as privileged scaffold in medicinal inorganic chemistry." In Privileged Scaffolds in Drug Discovery. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-443-18611-0.00019-x.

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Conference papers on the topic "Privileged scaffold"

1

Lazić, Anita, Ivana Đorđević, Kristina Gak Simić та ін. "Correlation of structure and potential pharmacological activity of spirohidantoins derived from α-Tetralone". У 37th International Congress on Process Industry. SMEITS, 2024. http://dx.doi.org/10.24094/ptk.024.279.

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Hydantoin is a nonaromatic five-membered heterocycle, which is considered a valuable, privileged scaffold in medicinal chemistry. The importance of the hydantoin scaffold in drug dis-covery has been reinforced by several medicines in clinical use, such as anticonvulsants (phenyto-in), antibiotics (nitrofurantoin), anticancer drugs (enzalutamide) and keratolytics (allantoin). To design new potentially pharmacologically active compounds, six spirohydantoin derivatives were synthetized and fully characterized by determination of the melting points, elemental analysis, FT-IR, 1H and 13C NMR spectr
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Medvedev, Michail, Michail Elinson, and Alexey Ilovaisky. "Green approach to the design of functionalized medicinally privileged 4-aryl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile scaffold !" In The 15th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2011. http://dx.doi.org/10.3390/ecsoc-15-00580.

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