Relevant bibliographies by topics / Privileged structure

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Privileged structure'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Privileged structure"

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Shah, Dhruvin R., Rahul P. Modh, and Kishor H. Chikhalia. "Privileged s-triazines: structure and pharmacological applications." Future Medicinal Chemistry 6, no. 4 (March 2014): 463–77. http://dx.doi.org/10.4155/fmc.13.212.

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Zhuang, Chunlin, Wen Zhang, Chunquan Sheng, Wannian Zhang, Chengguo Xing, and Zhenyuan Miao. "Chalcone: A Privileged Structure in Medicinal Chemistry." Chemical Reviews 117, no. 12 (May 10, 2017): 7762–810. http://dx.doi.org/10.1021/acs.chemrev.7b00020.

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Sun, De-Juan, Ling-Juan Zhu, Yu-Qian Zhao, Yong-Qi Zhen, Lan Zhang, Cong-Cong Lin, and Li-Xia Chen. "Diarylheptanoid: A privileged structure in drug discovery." Fitoterapia 142 (April 2020): 104490. http://dx.doi.org/10.1016/j.fitote.2020.104490.

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Li, Z., P. Zhan, and X. Liu. "1,3,4-Oxadiazole: A Privileged Structure in Antiviral Agents." Mini-Reviews in Medicinal Chemistry 11, no. 13 (November 1, 2011): 1130–42. http://dx.doi.org/10.2174/138955711797655407.

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Garuti, Laura, Marinella Roberti, Giovanni Bottegoni, and Mariarosaria Ferraro. "Diaryl Urea: A Privileged Structure in Anticancer Agents." Current Medicinal Chemistry 23, no. 15 (May 19, 2016): 1528–48. http://dx.doi.org/10.2174/0929867323666160411142532.

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McNaughton, Donald, Dennis Wachsmuth, Peter Kraus, Sven Herbers, Juan Wang, and Jens‐Uwe Grabow. "Determination of the “Privileged Structure” of 8‐Hydroxyquinoline." ChemPhysChem 22, no. 16 (July 7, 2021): 1692–97. http://dx.doi.org/10.1002/cphc.202100384.

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Ferreira Pimentel, Luiz Claudio, Anna Claudia Cunha, Lucas Villas Boas Hoelz, Henayle Fernandes Canzian, Debora Inacio Leite Firmino Marinho, Nubia Boechat, and Monica Macedo Bastos. "Phenylamino-pyrimidine (PAP) Privileged Structure: Synthesis and Medicinal Applications." Current Topics in Medicinal Chemistry 20, no. 3 (March 18, 2020): 227–43. http://dx.doi.org/10.2174/1568026620666200124094949.

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The phenylamino-pyrimidine (PAP) nucleus has been demonstrated to be useful for the development of new drugs and is present in a wide variety of antiretroviral agents and tyrosine kinase inhibitors (TKIs). This review aims to evaluate the application of PAP derivatives in drugs and other bioactive compounds. It was concluded that PAP derivatives are still worth exploring, as they may provide highly competitive ATP TKI’s with nano/picomolar activity.
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Hanley, Caroline. "Privileged Places: Race, Residence, and the Structure of Opportunity." Contemporary Sociology: A Journal of Reviews 36, no. 4 (July 2007): 335–37. http://dx.doi.org/10.1177/009430610703600411.

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Martín-Acosta, Pedro, Rosalyn Peña, Gabriela Feresin, Alejandro Tapia, Isabel Lorenzo-Castrillejo, Félix Machín, Ángel Amesty, and Ana Estévez-Braun. "Efficient Multicomponent Synthesis of Diverse Antibacterial Embelin-Privileged Structure Conjugates." Molecules 25, no. 14 (July 20, 2020): 3290. http://dx.doi.org/10.3390/molecules25143290.

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A library of embelin derivatives has been synthesized through a multicomponent reaction from embelin (1), aldehydes and privileged structures such as 4-hydroxycoumarin, 4-hydroxy-2H-pyran-2-one and 2-naphthol, in the presence of InCl3 as catalyst. This multicomponent reaction implies Knoevenagel condensation, Michael addition, intramolecular cyclization and dehydration. Many of the synthesized compounds were active and selective against Gram-positive bacteria, including one important multiresistant Staphylococcus aureus clinical isolate. It was found how the conjugation of diverse privileged substructure with embelin led to adducts having enhanced antibacterial activities.
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Bielby, William T. "Minority Vulnerability in Privileged Occupations." ANNALS of the American Academy of Political and Social Science 639, no. 1 (December 15, 2011): 13–32. http://dx.doi.org/10.1177/0002716211422338.

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Building on recent work on contemporary forms of bias in meritocratic personnel systems, the author assesses sources of racial disadvantage in an output-based pay-for-performance system for compensating financial advisers in a large financial services firm. Using data from expert reports submitted in racial discrimination litigation, the author shows how racial differences in access to white wealth, limits on African Americans’ full participation in broker teams, racialized approaches to multicultural marketing, and diffuse lines of authority for diversity and nondiscrimination created racial barriers that were sustained and amplified by a cumulative advantage system for allocating productivity-enhancing resources. The author concludes with a discussion of management strategies for minimizing minority vulnerability in privileged professions and the challenges faced when the sources of bias are neither unconscious nor unintended but are instead located at least in part in racially segregated social relations and power differences among professionals who hold formally equivalent positions in a company’s job structure.
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Dissertations / Theses on the topic "Privileged structure"

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Ravn, Jacob. "Development of privileged structure based libraries /." Måløv ; Cph. : Medicinal Chemistry Research III, Novo Nordisk A/S og Department of Medicinal Chemistry : The Danish University of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/jacobravn.htm.

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Buck, Michel. "A privileged quantum state from causal structure." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24574.

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This thesis investigates a new proposal for a privileged ground state of a free scalar quantum field in arbitrary regions of spacetime. This Sorkin-Johnston (SJ) state, implicit in work by S. Johnston on quantum field theory on causal sets, is defined solely in terms of the spacetime causal structure and is unique in any globally hyperbolic spacetime region. The first part of the thesis contains an analysis of the simplest possible setting: a flat two-dimensional causal interval. The simplicity of the setup makes analytic calculations tractable and allows for some general features of the state to be better understood. The second part deals with an investigation of the SJ state in de Sitter space. It turns out to be possible to construct the state explicitly using limiting procedures, which provides further interesting insights. In particular, the state is found to depend on the spacetime dimension, field mass, and on the choice of subregion, differing in many cases from the usual 'Bunch-Davies' vacuum. The formalism does not select a unique state in spacetimes that are not globally hyperbolic, which include, among others, spacetimes exhibiting spatial topology change. These are relevant in the context of quantum gravity and in relation to the old question as to whether violent spacetime curvature fluctuations at Planckian scales can lead to changes in spatial topology, or whether such transitions are unphysical. Some efforts to understand the SJ state in the topology-changing two-dimensional 'trousers' spacetime are discussed in the final part of the thesis.
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Annadurai, Sivakumar. "Lead generation using a privileged structure-based approach." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/213119.

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Pharmaceutical Sciences
Ph.D.
In drug discovery there are several approaches to lead generation and one traditional approach involves the synthesis and screening of a structurally diverse compound library against a number of biological targets to identify high affinity lead compounds. The use of a `privileged' structure-based compound library represents a viable approach that could lead to drug like lead compounds. Privileged structures are defined as those ligand substructures that may be used to generate high affinity leads for more than one type of receptor. Examples of privileged structures include phenyl substituted monocycles such as biphenyls, diphenyl methane derivatives, 1,4-dihydropyridines, fused ring systems such as chromones, quinoxalines, quinazolines, 2-benzoxazolones, indoles, benzimidazoles and benzofurans. There are several instances in the literature describing the development of compound libraries based on privileged structures with reportedly high hit rates. Privileged structure based approaches has been used with notable success in the identification of high affinity ligands especially for G-protein coupled receptors (GPCRs). The scaffold 2-aminothiazole (fused and non-fused) may be considered a privileged structure because of its occurrence in a wide variety of pharmaceuticals. The scaffold is found in antibacterials, anti-inflammatory agents, glutamate transporter (GLT-1) modulators, serotonin and muscarinic ligands. The present study involves the synthesis of a 2-aminothiazole (fused and non-fused) based compound library (60 compounds) by incorporating bioactive fragments shown to produce hits in the biological targets of interest. Microwave assisted organic synthesis (MAOS) has been employed at key steps of scaffold synthesis as well as in Suzuki coupling to generate the target aminothiazoles. Preliminary biological screening has resulted in the identification of some promising lead compounds. Trifluoromethoxy substituted aminothiazoles were found to be potent antimicrobials with MIC values in the range of 4-16 microgram/ml. Furanone based aminothiazoles showed affinity for muscarinic receptors. Piperidine based aminothiazoles showed greater than 90% of control (8-OH-DPAT) specific agonist response at the 5-HT1A receptor subtype. The Clog P values of the most potent antimicrobials were found to be in the range of 4.5-6.2 indicating the high lipophilicity of the compounds. High lipophilicity is known to cause solubility issues that may hamper future development. Therefore in an effort to make compounds with intermediate lipophilicity, the phenyl core of the potent aminothiazoles will be replaced with pyridine core using literature procedures (Pyridine core containing aminothiazoles showed Clog P < 4). Future plans include expanding the library, improving the yields of compounds and to evaluate the compounds as modulators of glutamate transporter (GLT-1). The work could be extended to include other privileged structures such as 2-aminooxazole, 2-aminobenzoxazole, 2-aminoimidazole and 2-aminobenzimidazole. These mono and bicyclic heterocyles may be considered bioisosteres of 2-aminothiazole.
Temple University--Theses
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Kim, Young-Woo. "Novel 2-substituted isoflavones a privileged structure approach to new agents for hormone-dependent breast cancer /." Columbus, Ohio : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1061576906.

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Thesis (Ph. D.)--Ohio State University, 2003.
Title from first page of PDF file. Document formatted into pages; contains xxiii, 249 p. : ill. Advisor: Robert W. Brueggemeier, College of Pharmacy. Includes bibliographical references (p. 234-249).
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Valot, Gaëlle. "Extending the diversity of privileged natural product motifs : Synthesis of a library of resorcylic acid lactones and studies towards the guaianes and pseudoguaianes." Strasbourg, 2011. https://publication-theses.unistra.fr/public/theses_doctorat/2011/VALOT_Gaelle_2011.pdf.

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Les macrolides du résorcinol présentant une fonction cis-enone se sont révélés être de puissants et irréversibles inhibiteurs de protéines kinases, des enzymes impliquées dans toutes les transductions de signaux dont le dysfonctionnement est à l’origine de pathologies telles que le cancer, les inflammations ou les maladies neurodégénératives. Attiré par leur activité biologique, notre laboratoire a développé une voie synthétique pour ces composés, basée sur la technologie des tags fluorés. La première partie de ma thèse a consisté à appliquer cette synthèse à l’élaboration d’une chimiothèque de 51 macrocycles. Cette dernière a permis d’identifier deux modifications permettant d’accroître l’activité biologique : l’ajout d’un carbone supplémentaire dans le macrocycle et d’un groupement hydroxyl en position β du diol. La seconde partie de ma thèse a consisté à développer une voie de synthèse générale permettant d’accéder à divers membres d’une autre classe de puissants inhibiteurs irréversibles : les lactones sesquiterpéniques. Ces composés présentent un large spectre de propriétés biologiques comme des propriétés cytotoxiques, anti-tumorales et anti-inflammatoires. Malheureusement la plupart des cibles biologiques et mécanismes associés à ces propriétés n’ont pas encore été identifiés. La voie de synthèse élaborée, basée sur un intermédiaire central bicyclique simple accessible en 13 étapes (avec pour étape clé une métathèse domino d’enyne) et inspirée de la biosynthèse, devrait permettre de développer des « composés outils » pour lever ces interrogations. Cette synthèse a notamment pu être appliquée à la préparation des molécules naturelles geigérine et 6-deoxy-geigérine
The resorcylic acid lactones bearing a cis-enone functionality proved to be potent and irreversible inhibitors of protein kinases, a class of enzymes implicated in every transduction pathways whose dysfunction is at the origin of pathologies ranging from oncology to inflammation and neurodegenerative diseases. Attracted by their important biological activity, our laboratory developed a synthetic pathway to these pharmacophores, based on the fluorous tags technology. The first part of my thesis consisted in applying this synthesis to the elaboration of a library of 51 macrocycles. This library allowed to identify two modifications as increasing the biological activity : the introduction of an extra carbon in the macrocycle and of a hydroxyl group in β position of the diol. The second part of my thesis consisted in developing a general synthetic pathway to access various members of another class of potent irreversible inhibitors : the sesquiterpene lactones. These compounds exibit a wide spectrum of biological activity including cytotoxic, anti-tumor and anti-inflammatory properties. Unfortunately most of the targets and mode of action associated with these properties have not been identified yet. The synthetic pathway developed, based on a simple central bicyclic intermediate achievable in 13 steps (with the key step being a domino enyne metathesis) and inspired by the biogenesis, should allow the development of "tool compounds" to address these questions. This synthesis has been applied in particular to the preparation of the natural products geigerin and 6-deoxy-geigerin
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Patterson, David Josh. "A Tale of Two Carlos: An Examination of the Ongoing Battle Between the Marginalized and the Privileged as Exemplified by Carlo Goldoni and Carlo Gozzi During the 18th Century." DigitalCommons@USU, 2011. https://digitalcommons.usu.edu/etd/1006.

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This thesis explores the lives and works of Carlo Gozzi and Carlo Goldoni. Specific emphasis is placed on their feud, positions in society, the motivations behind their theatrical styles, and the ways they used theatre to either attempt to maintain the status quo (Gozzi) or strive for social change (Goldoni). Contrary to previous studies, this study suggests that Goldoni tried to influence the world around him, rather than merely reflect it. This study examines the above through the lens of several twentieth century theories including semiotics, structuralism, and the avante-garde. The contents of this work are essential to anyone seeking biographical information, doing dramaturgical research or producing one of their plays, and those investigating the ways theatre has been used to incite change and create an atmosphere of social equity. This work demonstrates that theatre can, has been, and should be actively used to influence that change.
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Wright, Angela J. "The asymmetric synthesis of B-amino acid derived privileged structures." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534191.

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Bispo, Júnior Walfrido. "Estudo da atividade antinoceptiva e anti-inflamatoria protótipos de fármacos." Universidade Federal de Alagoas, 2013. http://www.repositorio.ufal.br/handle/riufal/3551.

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This work was conducted to evaluate the activity anti-inflammatory and antinocieptive two series of derivatives of N-acilidrazonas (NAH) rationally designed and synthesized by LASSBio® UFRJ. The first series consists of four compounds, being two metal complexes generated from the coordination of prototypes LASSBio-1064 and LASSBio-466 and second prototype LASSBio-1064 and LASSBio-466. The second series comprised eight derivatives, designed as structural analogues of piroxicam. Were performed nociception models of functional chemical (writhing induced by acetic acid 0.1 N, formalin test), thermal nociception (hot plate test), cell migration assay (peritonitis induced by zymosan A and / or induced by carrageenin) assay evaluation of inhibition of COX-1/COX-2. All compounds and standards were administered 40 min before starting the test (p.o) at a dose of 100 mmol / kg. In the first series, Animal constriction induced by acetic acid was inhibited by all the compounds studied, highlighting the [Zn(LASSBio-466)H2O]2 and H2LASSBio-1064 that inhibited (p˂0.01) at 82.7 % (p˂0.01) and 81.3% (p˂0.01) the number of writhes, as the standard drug (dipyrone) inhibited 77.7% (p˂0.01). In the first phase of the formalin test H2LASSBio-466 and H2LASSBio-1064 reduced the latency time to lick 53.1% (p ˂ 0.05) and 46.5% (p˂0.01), respectively. In the second phase of the test compounds H2LASSBio-1064 and [Zn(LASSBio-466)H2O]2 reduced the latency time to lick at 48.5% (p˂0.05) and 37.3% (p˂0.05), respectively. All compounds showed levels of inhibition of peritonitis induced by zymosan comparable or superior to indomethacin (drug standard). In the second series, the compounds were active in the assay of writhing induced by acetic acid highlighting the LASSBio-1638, LASSBio-1604 and LASSBio-1639 inhibited the contortions that abdmoniais in 84.0% (p˂0.01), 82.7% (p˂ 0.01) and 90.4% (p˂ 0.01), respectively, whereas piroxicam (drug standard), inhibited by 95.4% (p˂0.01) . In the formalin test, only LASSBio-1617 significantly inhibited the nociceptive activity in the first stage by 58.2% (p<0.01). In the second phase the LASSBio-1637, LASSBio-1638 inhibited the nociceptive activity in 60.0% (p<0.05) and 54.2% (p<0.05), respectively, and piroxicam inhibited 53.9 % (p<0.01). In models of acute inflammation, the compounds showed inhibitory activity against cell migration similar to or greater than the piroxicam. In the trial of carrageenan-induced acute peritonitis compounds LASSBio-1604LASSBio-1637, LASSBio-1638 and LASSBio-1639 inhibited cell migration by 74.2% (p˂ 0.01), 73.2% (p˂0.01), 77.6% (p˂ 0.01) and 81.8% (p ˂ 0.01), respectively, where as piroxicam inhibited by 25.5% (p˂0.01). The compounds LASSBio-1637, LASSBio-1638-1639 and LASSBio highlighted in the testing of acute peritonitis induced by zymosan A, inhibiting cell migration in 78.6% (p˂0.01), 81.2% (p ˂ 0.01) and 82.7% (p ˂ 0.01), showing that, in this essay, more active than piroxicam (57.3%). LASSBio-1604 and LASSBio-1617 inhibited the enzyme COX in vitro, presenting, respectively, IC50 values of 0.22 M and 0.28 M for inhibition of COX-1 and 0.24 M and 0.26 M for inhibition of COX-2. Pharmacological Evaluation results suggest that in the first series, the coordination of zinc (II) is a good strategy to improve the antinociceptive activity of the compound H2LASSBio-466 associated with inflammatory pain, and in the second series, all compounds exhibit antinociceptive and anti-inflammatory similar or superior to piroxicam.
Neste trabalho foi realizado a avaliação da atividade antinocieptiva e anti-inflamatória de duas séries de derivados N-acilidrazonas (NAH) racionalmente planejadas e sintetizados pelo LASSBio® da UFRJ. A primeira serie é formada de 4 compostos, sendo 2 complexos metálicos gerados a partir da coordenação dos protótipos LASSBio-466 e LASSBio-1064 e 2 protótipos LASSBio-466 e LASSBio-1064. A segunda série formada por 8 derivados, desenhados como análogos estruturais do piroxicam. Foram realizados modelos funcionais de nocicepção química (contorção abdominal induzida por ácido acético 0,1N, ensaio de formalina), nocicepção térmica (ensaio da placa quente), ensaio de migração celular (peritonite induzido por zymosan A e/ou induzido por carragenina) ensaio de avaliação de inibição da COX-1/COX-2. Todos os compostos e padrões foram administrados 40 min antes do início ensaio (vo) na dose de 100 μmol/kg. Na primeira série, a constrição animal induzida por ácido acético foi inibida por todos os compostos estudados, destacando-se o [Zn(LASSBio-466)H2O]2 e H2LASSBio-1064 que inibiram (p˂0,01) em 82,7% (p˂0,01) e 81,3% (p˂0,01) o numero de contorções, enquanto o fármaco-padrão (dipirona) inibiu em 77,7% (p˂0,01). Na primeira fase do ensaio de formalina o H2LASSBio-1064 e H2LASSBio-466 reduziram o tempo de latência de lambida em 53,1% (p˂0,05) e 46,5% p˂0,01), respectivamente. Já na segunda fase do ensaio os compostos H2LASSBio-1064 e [Zn(LASSBio-466) H2O]2 reduziram o tempo de latência de lambida em em 48,5% (p˂0,05) e 37,3% (p˂0,05), respectivamente. Todos os compostos mostraram níveis de inibição da peritonite induzida por zymosan comparáveis ou superiores à indometacina (fármaco padrão). Na segunda série, os compostos mostraram-se ativas no ensaio de contorções abdominais induzida por acido acético destacando-se o LASSBio-1638, LASSBio-1639 e LASSBio-1604 que inibiram as contorções abdmoniais em 84,0% (p˂0,01), 82,7% (p˂0,01) e 90,4% (p˂0,01), respectivamente, ao passo que o piroxicam (fármaco padrão) inibiu em 95,4% (p˂0,01). No teste de formalina, apenas LASSBio-1617 inibiu significativamente a atividade nociceptiva na primeira fase em 58,2% (p <0,01). Na segunda fase o LASSBio-1637, LASSBio-1638 inibiram a atividade nociceptiva em 60,0% (p <0,05), e 54,2% (p <0,05), respectivamente, e o piroxicam inibiu em 53,9% (p <0,01). Em modelos de inflamação aguda, os compostos apresentaram atividade inibitória sobre a migração celular semelhante ou maior que o piroxicam. No ensaio de peritonite aguda induzida por carragenina os compostos LASSBio-1604, LASSBio-1637, LASSBio-1638 e LASSBio-1639 inibiram a migração celular em 74,2% (p˂0,01), 73,2% (p˂0,01), 77,6% (p˂0,01) e 81,8% (p˂0,01), respectivamente, ao passo que o piroxicam inibiu 25,5% (p˂0,01). Os compostos LASSBio-1637, LASSBio-1638 e LASSBio-1639 destacaram-se no ensaio de peritonite aguda induzida por zymosan A, inibindo a migração celular em 78,6% (p˂0,01), 81,2% (p˂0,01) e 82,7% (p˂0,01), mostrando-se, nesse ensaio, mais ativos que o piroxicam (57,3%). LASSBio-1604 e LASSBio-1617 inibiram a enzima COX in vitro, apresentando, respectivamente, valores de CI50 de 0,22 M e 0,28 M para inibição de COX-1 e 0,24 M e 0,26 M para inibição de COX-2. Os resultados da avaliação farmacológica sugerem que, na primeira série, a coordenação do zinco (II) é uma boa estratégia para melhorar a atividade antinociceptiva do composto H2LASSBio-466 associada a dor inflamatória, e na segunda série, que todos compostos apresentam atividades antinociceptiva e anti-inflamatória semelhantes ou superiores ao piroxicam.
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Balakrishnan, Shalini. "Development of novel switchable motifs and new strategies to build functionally privileged structures." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 220 p, 2007. http://proquest.umi.com/pqdweb?did=1464120641&sid=2&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Di, Martino Rita Maria Concetta <1987&gt. "Naturally Inspired Privileged Structures in Drug Discovery: Multifunctional Compounds for Alzheimer's Disease Treatment." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7582/.

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Polypharmacology-based strategies are gaining ever-increasing attention as useful approaches to develop disease-modifying drug candidates for effective Alzheimer’s disease (AD) treatment. In this scenario, multitarget-directed ligands could increase efficiency by simultaneous modulation of several targets involved in AD pathogenesis. In drug discovery, natural products (NPs) represent an excellent source of evolutionary-chosen “privileged structures”. In this thesis, the polyphenol curcumin, found in Curcuma longa L, encompassing the essential structural elements for the concurrent inhibition of two validated AD targets, BACE-1 and GSK-3β, was rationally identified as lead compound. Aimed at developing well-balanced dual BACE-1/GSK-3β modulators with good BBB permeability, different series of curcumin-based derivatives were designed and synthetized by introducing suitable chemical modifications on the side aryl ring(s) and in the 4-position of the main scaffold. Furthermore, considering the pivotal role of the intramolecular H-bond network of curcumin’s central fragment in establishing appropriate interactions with target binding sites, several complexation and bioisosteric cyclization strategies were performed. Thanks to its strong Michael acceptor reactivity toward critical cysteine residues, curcumin exerts neuroprotection by additional activation of the Keap1-Nrf2-ARE signaling pathway. Thus, aimed at affecting the electrophilicity of its α,β-unsaturated carbonyl fragment, allowing a fine-tuning of its reactivity, diverse electrophilic functions were inserted in different positions of the curcumin scaffold. Furthermore, considering the neuroprotective and antioxidant potentials of simple coumarins, several curcumin-coumarin hybrids were also prepared. Recently, the inhibition of additional AD-correlated protein kinases (PKs), such as CK1 and LRRK2, could offer promises to achieve a successful treatment and indole was envisaged as useful scaffold for both PKs’ inhibition. Thus, a small library of indole-based derivatives was designed and synthetized as valuable BBB permeable pharmacological tools. Finally, chitosan (CS), a natural, nontoxic, biocompatible and biodegradable polysaccharide, was selected to develop CS-based bioconjugates for nanoparticles’ preparation as innovative drug delivery and targeting systems.
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Books on the topic "Privileged structure"

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Yet, Larry. Privileged Structures in Drug Discovery. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2018. http://dx.doi.org/10.1002/9781118686263.

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Ozer, Mark N. Massachusetts Avenue in the Gilded Age: Palaces & privilege. Charleston, SC: History Press, 2010.

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Land and privilege in Byzantium: The institution of pronoia. Cambridge: Cambridge University Press, 2012.

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Massachusetts Avenue in the Gilded Age: Palaces and privilege. Charleston, SC: History Press, 2010.

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Bazzoni, Giancarlo. Il caso Cavalli e le origini di Porto Corsini: 1671-1802 : nobiltà e privilegi a Ravenna nel secolo XVII. Ravenna: Fondazione Cassa di risparmio di Ravenna, 1999.

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Privilege, power, and place: The geography of the American upper class. Lanham, Md: Rowman & Littlefield Publishers, 1995.

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Villa Piatti e il feudo di Pigozzo Veronese: Anno 1073 : il Privilegio di Beatrice e Matilde di Canossa a favore dell'Abbazia di San Zeno Maggiore. Verona: QuiEdit, 2009.

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Cicero, Patrizia Lo. Villa Piatti e il feudo di Pigozzo Veronese: Anno 1073 : il Privilegio di Beatrice e Matilde di Canossa a favore dell'Abbazia di San Zeno Maggiore. Verona: QuiEdit, 2009.

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Kubrin, Charis E., and Gregory D. Squires. Privileged Places: Race, Residence, And the Structure of Opportunity. Lynne Rienner Publishers, 2006.

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Spinley, B. M. The Deprived and the Privileged: International Library of Sociology I: Class, Race and Social Structure (International Library of Sociology). Routledge, 2003.

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Book chapters on the topic "Privileged structure"

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Gossage, Robert A. "Pincer Complexes of Lithium, Sodium, Magnesium and Related Metals: A Discussion of Solution and Solid-State Aggregated Structure and Reactivity." In The Privileged Pincer-Metal Platform: Coordination Chemistry & Applications, 17–44. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/3418_2015_119.

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Bywater, R. P. "Privileged Structures in GPCRs." In Ernst Schering Foundation Symposium Proceedings, 75–92. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/2789_2006_004.

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Fallani, Andrea. "La rielaborazione dei mitemi orfici in Microcosmi. Tra vulgata classica e favola indiana." In Biblioteca di Studi di Filologia Moderna, 355–71. Florence: Firenze University Press, 2021. http://dx.doi.org/10.36253/978-88-5518-338-3.27.

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Starting from the critics’ observations about the structure of Microcosmi, the essay focuses on the key role played by the love story between the protagonist-narrator and his wife Marisa, a sort of rewriting of Orpheus and Eurydice’s myth. Convergences and variations between the classic vulgate of the myth and the pseudo-rewriting of Microcosmi are highlighted. The essay also focuses on the Indian myth of Savitri and Sátiavan, to understand the source of the many substantial variations and, in particular, the reversal of roles between male and female characters. This myth turns out to be a privileged source for the rewritings of the Orpheus’ myth that are offered by Magris in his Microcosmi.
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Kubinyi, Hugo. "Privileged Structures and Analogue-Based Drug Discovery." In Analogue-based Drug Discovery, 53–68. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2006. http://dx.doi.org/10.1002/3527608001.ch3.

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Mohatt, Nathaniel Vincent, and Dennis Mohatt. "Rural Prejudice-Urban Bias: The Stories and Structures That Oppress Rural Communities." In Prejudice, Stigma, Privilege, and Oppression, 413–25. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-35517-3_23.

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Kallio, Alexis Anja. "Doing Dirty Work: Listening for Ignorance Among the Ruins of Reflexivity in Music Education Research." In The Politics of Diversity in Music Education, 53–67. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-65617-1_5.

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AbstractRecent research in music education has emphasized the importance of reflexive approaches in unsettling the concept of a neutral, objective researcher and critically considered the ways in which cultural others are represented in research texts. Seen to enhance both the rigor and ethical dimensions of research practice, reflexivity has emerged as a hegemonic virtue, highlighting the inherently political aspects of research practice. In this chapter, I interrogate the politics of inquiry involved in reflexive research, considering the ways in which reflexivity may afford the researcher methodological power and hinder relational and responsible work. Reflexivity is thus positioned as a ruin: perpetually reaffirming the benevolence of the already-privileged researcher while doing little to disrupt the structures that keep such privileges at the center of academic practice. However, rather than abandoning such practices altogether, I suggest that reflexivity might be better considered as a way to listen for ignorance and direct attention toward ontological or epistemological difference. In this way, reflexivity serves as an invitation to engage in the politics of diversity through the transformation of researchers themselves.
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Sun, Shiding, Chunhua Zhang, and Yingjie Tian. "A New Method for Structured Learning with Privileged Information." In Lecture Notes in Computer Science, 453–61. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-93701-4_35.

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Meutermans, Wim D. F., Simon W. Golding, Marc R. Campitelli, Douglas A. Horton, Gregory T. Bourne, and Mark L. Smythe. "Privilege Structures: New Strategies for the Synthesis of Cyclic Tetrapeptides." In Peptides: The Wave of the Future, 122–24. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0464-0_54.

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Benn, Emma. "Power and Privilege: Reshaping the Opportunity Structure for Equitable Leadership in Statistics and Data Science." In Leadership in Statistics and Data Science, 19–28. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-60060-0_2.

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Fibbi, Rosita, Arnfinn H. Midtbøen, and Patrick Simon. "Theories of Discrimination." In IMISCOE Research Series, 21–41. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-67281-2_3.

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AbstractThis chapter reviews the main theories developed to explain discrimination. Mirroring the historical development of the field, while reflecting a theoretically systematic approach, the chapter adopts an approach by analytical scales to present and discuss theories of discrimination. The first section presents theories seeking the cause of prejudice and discrimination at the individual level, the second section focuses on organizational mechanisms and the third on structural determinants. In conclusion, we emphasize that despite of these different levels of analysis, the various theories of discrimination reviewed share a common feature, namely the fact that discrimination maintains privileges of certain ascribed groups over others
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Conference papers on the topic "Privileged structure"

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Podlesskaya, V. I. ""A TOT PEROVSKOJ NE DAL VSLAST' POSPAT'": PROSODY AND GRAMMAR OF ANAPHORIC TOT THROUGH THE LENS OF CORPUS DATA." In International Conference on Computational Linguistics and Intellectual Technologies "Dialogue". Russian State University for the Humanities, 2020. http://dx.doi.org/10.28995/2075-7182-2020-19-628-643.

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Based on data from the Russian National Corpus and the General InternetCorpus of Russian, the paper addresses syntactic, sematic and prosodic features of constructions with the demonstrative TOT used as an anaphor. These constructions have gained some attention in earlier studies [Paducheva 2016], [Berger, Weiss 1987], [Kibrik 2011], [Podlesskaya 2001], but their analysis (a) covered primarily their prototypical uses; and (b) was based on written data. The data from informal, esp. from spoken discourse show however that the actual use of these constructions may deviate considerably from the known prototype. The paper aims at bridging this gap. I claim (i) that the function of TOT is to temporary promote a referent from a less privileged discourse status to a more privileged one; and (ii) that TOT can be analyzed on a par with switch reference devices in the languages where the latter are grammatically marked (e.g. on verb forms). The following parameters of TOT-constructions are discussed: syntactic and semantic roles of TOT and of its antecedent in their respective clauses, linear and structural distances between TOT and its antecedent, animacy of the maintained referent. Special attention is payed to the information structure of the TOT construction: I give structural and prosodic evidence that TOT never has a rhematic status. The revealed actual distribution of TOT (a) adds to our understanding of cross-linguistic variation of anaphoric functions of demonstratives; and, hopefully, (b) may contribute to further developing computational approaches to coreference and anaphora resolution for Russian, e.g. by improving datasets necessary for this task.
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Pesant, Gilles. "From Support Propagation to Belief Propagation in Constraint Programming (Extended Abstract)." In Twenty-Ninth International Joint Conference on Artificial Intelligence and Seventeenth Pacific Rim International Conference on Artificial Intelligence {IJCAI-PRICAI-20}. California: International Joint Conferences on Artificial Intelligence Organization, 2020. http://dx.doi.org/10.24963/ijcai.2020/715.

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The distinctive driving force of constraint programming (CP) to solve combinatorial problems has been a privileged access to problem structure through the high-level models it uses. We investigate a richer propagation medium for CP made possible by recent work on counting solutions inside constraints. Beliefs about individual variable-value assignments are exchanged between contraints and iteratively adjusted. Its advantage over standard belief propagation is that the higher-level models do not tend to create as many cycles, which are known to be problematic for convergence. We find that it significantly improves search guidance.
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Zhu, Wenfang, Xiuyi Jia, and Weiwei Li. "Privileged label enhancement with multi-label learning." In Twenty-Ninth International Joint Conference on Artificial Intelligence and Seventeenth Pacific Rim International Conference on Artificial Intelligence {IJCAI-PRICAI-20}. California: International Joint Conferences on Artificial Intelligence Organization, 2020. http://dx.doi.org/10.24963/ijcai.2020/329.

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Label distribution learning has attracted more and more attention in view of its more generalized ability to express the label ambiguity. However, it is much more expensive to obtain the label distribution information of the data rather than the logical labels. Thus, label enhancement is proposed to recover the label distributions from the logical labels. In this paper, we propose a novel label enhancement method by using privileged information. We first apply a multi-label learning model to implicitly capture the complex structural information between instances and generate the privileged information. Second, we adopt LUPI (learning with privileged information) paradigm to utilize the privileged information and employ RSVM+ as the prediction model. Finally, comparison experiments on 12 datasets demonstrate that our proposal can better fit the ground-truth label distributions.
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Zunno, Antonio. "La fortezza e il suo giardino: uno sguardo dal mare." In FORTMED2020 - Defensive Architecture of the Mediterranean. Valencia: Universitat Politàcnica de València, 2020. http://dx.doi.org/10.4995/fortmed2020.2020.11368.

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The fortress and its garden: a view from the seaThe Fortress was built from 1554, on the ruins of an ancient convent, at the behest of Philip of Austria, and it was completed in about 55 years under the direction of Giulio Cesare Falco, knight of the Order of Malta and Captain General against the Turks. The maine structure, called Forte a Mare, was joined with the Opera a Corno, a mighty rampart with the function of enclosure of the intermediate island, separated from the other island in 1598 by the construction of the Angevin canal: here were arranged the lodgings of the troops and garrisons. Castello and Forte, were named by the Spaniards Isla Fortalera que abre el Puerto Grande, because of its particular position to protect the port. The complex was entrusted to the Germans in 1715, then conquered by the French Revolutionaries and, in 1815, re-annexed to the Kingdom of Naples and destined to lazaretto. A period of decline follows until the end of the 19th century when Brindisi became a first class naval base and the fort became a garrison of the Royal Navy, destined, during the Great War, to recover torpedoes and detonators The recovery of the complex, starting in the 1980s, allowed the conservation of the structures but was never included in a real valorisation program. With this intervention in progress, a first visit is expected through the visit from the walkways through a circular route from the Castle to the whole Opera in Corno: the itinerary will allow you to retrace the history of the Fortress and enjoy a unique view from the high towards the sea, also through the passage in a curtain of Mediterranean scrub that has colonized the walls over the centuries, creating a veritable hanging garden on the sea. The aim is to lead the visitor to the rediscovery a forgotten place that is closely connected to the coastal landscape, for which it is a privileged point of view also in relation to the city and the port.
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Fang, Chien, and Li Nianzhong. "Urban Design Practice in "Instant New Towns"." In 1995 ACSA International Conference. ACSA Press, 1995. http://dx.doi.org/10.35483/acsa.intl.1995.46.

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Shenzhen is a lengendary city booming out from a small fishing village within ten years. It is situated at the south end of China, along eastern side of the Pearl River opening to the South China Sea. As one of the earliest of four Special Economic Zones in China since 198 1, Shenzhen has enjoyed a set of privileged economic policies and turned into an energetic metropolis with population of over three million. According to the strategic planning, Shenzhen will expand to an area of nearly 2000 square kilometers from 300 square kilometers right now. The local government seeks to realize 100% urbanization in Shenzhen in a short time. In other words, the whole outskirts and rural area will be urbanized. In the conprehensive plannning, the surburb, formerly Baoan county, is becoming another two districts (Baoan and Longgang) besides the existing three districts (Luohu, Futian, and Nanshan). The grouped structure of urban layout in the planning attempts to organize the present villages and towns in the outskii into 8 groups (4 in each district), which are assigned different priority urban bctions such as transportation, communication, industry, tourism, district centre, etc. Generalization of the project of Longgang District Planning Our project is concerned with the zone planning ofthe central group in Longgang district. It consists of Longgang, Pingdi, and Pingdi Centre, covers an area of over 180 square kilometers, and holds population of 200,000. According to the strategic plan, the group is to develop into the future admistrative, commercial, and cultural center of Longgang district. The study of urban design is one important field in our project.
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Meneguele, Bruno, Keiko Fonseca, and Marcelo Rosa. "Secure Kernel Execution with Intel SGX." In Simpósio Brasileiro de Engenharia de Sistemas Computacionais. Sociedade Brasileira de Computação, 2020. http://dx.doi.org/10.5753/sbesc_estendido.2020.13108.

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Intel SGX is not accessible from the most privileged execution level, known as ring zero, where the operating system kernel is placed. However, it is possible to split the execution responsibility between kernel and userspace by creating a dependency among these two levels that allow internal kernel data to be stored or processed within SGX private enclaves. In this paper we present SKEEN, an enhanced way to isolate internal operating system components and structures with Intel SGX technology, preventing information leak to different components of the same operating system. A proof-of-concept is provided to exemplify its usage.
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Joshi, Alhad, Binu Panicker, and Shashidhar Lakshminarayana. "Product Performance Validation Life Cycle Management." In ASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2009. http://dx.doi.org/10.1115/detc2009-86088.

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This paper will discuss critical issues and needs in the product performance validation domain. There is a primary need to manage a vast variety of CAE and Test data files that are used and generated throughout the product performance life cycle. The paper will discuss the different elements of managing such data including basic data structures, process and work flow requirements, product validation plans, and security and access privilege considerations. The goal of executing CAE Analysis or performing physical tests is to gather all product performance information. Evaluating all performance measurements specified for the product makes it possible to ensure that the product will behave as specified throughout its service life. The key here is that decision makers need access to all possible performance metrics for a product, an assembly or a component. There is a primary need to manage a vast variety of CAE and Test data files that are used and generated through the product performance life cycle. The paper addresses the different elements of managing such data including basic data structures, process and work flow requirements, product validation plans, security access privilege considerations and data standardization. This paper will also outline how the product validation management system architecture can support all the needs of this domain. The principal elements of the system include the supporting data structures that are mapped to a database management system and access methods using a service-oriented architecture (SOA).
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de Fraguier, Eric, Antoine Guelfi, Luc Vanhoenacker, Olivier Rousselot, Michel Béolet, and Valérie Bellens. "The European Utility Requirements (EUR): A Great Achievement and Still on its Way." In 2013 21st International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/icone21-16914.

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Twenty years ago, a small group of representatives of European electricity producers involved in nuclear generation set up a light structure called the European Utility Requirements organisation. Its long-term objective was to foster the development of competition in the European nuclear industry through writing common design requirements for the new plants. The stabilised version of the specifications (the Revision C) was released in 2001 and since that time it has been extensively used by the utilities that were preparing bids as well as by the vendors that were developing new projects. The EUR has become a reference document, well beyond the initial circle of European utilities that promoted it. Today, the first challenge for the EUR organisation is to promote the issue of revision D of the document (October 2012). Ten years after the last revision, many technological advances and requirements needed to be revised in the effort to keep utilities’ requirements at the highest level. Their role in design of future plants is essential more than ever in the quest for maximum standardisation, itself necessary to maintain the competitiveness of nuclear power in Europe. The second challenge is to take into account the effects of the Fukushima accident. The EUR organisation must not only continue working on the technical impacts as the feedback will be worked out and their integration into the EUR requirements; but it has also to focus on reactions to the disaster among all stakeholders around the world. And support harmonisation processes broadly, in this respect. This is one way to contribute to better acceptance of nuclear energy, while the control of greenhouse gas emissions remains a major global challenge. The third challenge for the future of the EUR organisation lies in strengthening of the links and incorporating the views of its members, particularly through collaborative workgroups, so that the Nuclear Option remains open in future decisions to build new power plants wherever accepted. This will involve the organisation in further enhancing its role as a privileged interface for discussions between utilities, vendors and European regulators. For twenty years the EUR organisation and its members have been able to work together and develop a common vision of the pace of political and economic consolidation of Europe and its enlargement to the East. The pioneers of the approach have been joined by a new generation of contributors. New members have brought their expertise to the organisation. Recently, others have put their participation in standby according to the evolution of their respective nuclear national policy. EUR keeps the way open for future and is proud of being part of nuclear stakeholders promoting standardisation and high quality requirements recognised by the Industry for future new Generation 3 plants.
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Đurić, Stefan, and Bojana Lalatović. "SOLIDARITY CHECK IN TIMES OF COVID-19. ANALYSIS OF THE EU APPROACH TOWARDS ITS CLOSEST NEIGHBOURS WITH A SPECIAL FOCUS ON MONTENEGRO." In EU 2021 – The future of the EU in and after the pandemic. Faculty of Law, Josip Juraj Strossmayer University of Osijek, 2021. http://dx.doi.org/10.25234/eclic/18303.

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Solidarity as one of the cornerstone values of the European Union has been once again seated on the red chair and intensively discussed within the European Union and broader. After the economic recession and migrant crisis that marked the last two decades, the outbreak of the COVID-19 pandemic has once again harshly tested the fundamental objectives and values of the European Union and the responsiveness and effectiveness of its governance system on many fronts. In April, 2020 several EU Member States were among the worst affected countries worldwide and this situation soon became similar in their closest neighbourhood. It put a huge pressure on the EU to act faster, while at the same time placing this sui generis community to the test that led to revealing its strengths and weaknesses. As it happened in the previous crises, the Union launched policies and various programmes that were meant to lessen the burden of the Member States and aspiring countries caused by the crises. The objectives of the mentioned soft law instruments that the EU adopted during the COVID-19 crisis has been not only to show that EU law is equipped to react to health and economic crises rapidly but to deliver its support in terms of solidarity to its Member States and its closest neighbours facing the unprecedented health and economic crisis. This article will explore the value and implication of the solidarity principle in times of Covid-19 in its various manifestations. A special focus will be on the financial and material aspects of the EU instruments created to combat the negative consequences of the pandemic and their further impact on shaping the solidarity principle within the EU system. While examining the character and types of these mechanisms a special focus will be placed on those available to Western Balkan countries, whereas Montenegro as the “fast runner” in the EU integration process will be taken as a case study for the purpose of more detailed analyses. One of the major conclusions of the paper will be that although the speed of the EU reactions due to highly complex structure of decision making was not always satisfying for all the actors concerned, the EU once again has shown that it is reliable and that it treats the Western Balkan countries as privileged partners all for the sake of ending pandemic and launching the socio-economic recovery of the Western Balkans. Analytical and comparative methods will be dominantly relied upon throughout the paper. This will allow the authors to draw the main conclusions of the paper and assess the degree of solidarity as well as the effectiveness of the existing EU instruments that are available to Montenegro and aimed at diminishing negative consequences of the crisis.
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Ve´tel, Je´roˆme, Andre´ Garon, and Dominique Pelletier. "Analysis of Complex Flows From Experimental Data and Numerical Experiments." In ASME 2010 3rd Joint US-European Fluids Engineering Summer Meeting collocated with 8th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2010. http://dx.doi.org/10.1115/fedsm-icnmm2010-30033.

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Fluid mechanics is considered to be a privileged field in physics because phenomena can be made visible. This is unfortunately not the case in turbulence where diffusion and mixing of passive tracers are enhanced by turbulent transport. Consequently, the analysis of the rich flow physics provided by direct numerical simulations (DNS) and by modern optical diagnostic techniques require advanced post-processing tools to extract fine flow details. In this context, this paper reviews most recent techniques used to reveal coherent structures and their dynamics in turbulent flows. In particular, results obtained with standard Eulerian techniques are compared to those obtained from a more recent Lagrangian technique. Even if this latter technique can provide finer details, it is found that the two methods are complementary. This is illustrated with DNS results and with experimental data including planar measurements as well as time-resolved measurements converted to quasi-instantaneous volumetric data by using the Taylor hypothesis.
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