Academic literature on the topic 'PRKN'

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Journal articles on the topic "PRKN"

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Bustillos, Bernardo A., Liam T. Cocker, Mathew A. Coban, et al. "Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W." Cells 13, no. 18 (2024): 1540. http://dx.doi.org/10.3390/cells13181540.

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Mutations in the PINK1 and PRKN genes are the most frequent genetic cause of early-onset Parkinson disease. The pathogenic p.R275W substitution in PRKN is the most frequent substitution observed in patients, and thus far has been characterized mostly through overexpression models that suggest a possible gain of toxic misfunction. However, its effects under endogenous conditions are largely unknown. We used patient fibroblasts, isogenic neurons, and post-mortem human brain samples from carriers with and without PRKN p.R275W to assess functional impact. Immunoblot analysis and immunofluorescence
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Lubbe, Steven J., Bernabe I. Bustos, Jing Hu, et al. "Assessing the relationship between monoallelic PRKN mutations and Parkinson’s risk." Human Molecular Genetics 30, no. 1 (2021): 78–86. http://dx.doi.org/10.1093/hmg/ddaa273.

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Abstract Biallelic Parkin (PRKN) mutations cause autosomal recessive Parkinson’s disease (PD); however, the role of monoallelic PRKN mutations as a risk factor for PD remains unclear. We investigated the role of single heterozygous PRKN mutations in three large independent case-control cohorts totalling 10 858 PD cases and 8328 controls. Overall, after exclusion of biallelic carriers, single PRKN mutations were more common in PD than controls conferring a >1.5-fold increase in the risk of PD [P-value (P) = 0.035], with meta-analysis (19 574 PD cases and 468 488 controls) confirming incr
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Koinuma, Takahiro, Taku Hatano, Koji Kamagata, et al. "Diffusion MRI Captures White Matter Microstructure Alterations in PRKN Disease." Journal of Parkinson's Disease 11, no. 3 (2021): 1221–35. http://dx.doi.org/10.3233/jpd-202495.

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Background: Although pathological studies usually indicate pure dopaminergic neuronal degeneration in patients with parkin (PRKN) mutations, there is no evidence to date regarding white matter (WM) pathology. A previous diffusion MRI study has revealed WM microstructural alterations caused by systemic oxidative stress in idiopathic Parkinson’s disease (PD), and we found that PRKN patients have systemic oxidative stress in serum biomarker studies. Thus, we hypothesized that PRKN mutations might lead to WM abnormalities. Objective: To investigate whether there are WM microstructural abnormalitie
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Borsche, Max, Inke R. König, Sylvie Delcambre, et al. "Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism." Brain 143, no. 10 (2020): 3041–51. http://dx.doi.org/10.1093/brain/awaa246.

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Abstract There is increasing evidence for a role of inflammation in Parkinson’s disease. Recent research in murine models suggests that parkin and PINK1 deficiency leads to impaired mitophagy, which causes the release of mitochondrial DNA (mtDNA), thereby triggering inflammation. Specifically, the CGAS (cyclic GMP-AMP synthase)-STING (stimulator of interferon genes) pathway mitigates activation of the innate immune system, quantifiable as increased interleukin-6 (IL6) levels. However, the role of IL6 and circulating cell-free mtDNA in unaffected and affected individuals harbouring mutations in
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Hagan, A. K., K. L. Bowen, A. Strayer-Scherer, H. L. Campbell, and C. Parker. "Interaction of peanut root-knot susceptible and resistant cultivars with nematicides for managing Meloidogyne arenaria and yield response in peanut." Peanut Science 52, no. 1 (2025): 38–49. https://doi.org/10.3146/0095-3679-52.1-ps1639.

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Peanut is an important crop in Alabama, where it is vulnerable to damage by root-knot nematodes, particularly peanut root-knot nematodes (PRKN, Meloidogyne arenaria Race 1). Peanut cultivars with resistance to this nematode, as well as nematicides, are used for minimizing yield losses due to PRKN. In this study, the efficacy of the nematicides fluopyram and aldicarb, applied in-furrow, along with cultivar resistance, are evaluated for managing PRKN populations and damage attributed to them, as well as impacts on pod yields and non-target effects on other diseases. In 2016, 2017, and 2018 on an
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Di Rita, Anthea, Teresa Maiorino, Krenare Bruqi, Floriana Volpicelli, Gian Carlo Bellenchi, and Flavie Strappazzon. "miR-218 Inhibits Mitochondrial Clearance by Targeting PRKN E3 Ubiquitin Ligase." International Journal of Molecular Sciences 21, no. 1 (2020): 355. http://dx.doi.org/10.3390/ijms21010355.

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The selective elimination of dysfunctional mitochondria through mitophagy is crucial for preserving mitochondrial quality and cellular homeostasis. The most described mitophagy pathway is regulated by a positive ubiquitylation feedback loop in which the PINK1 (PTEN induced kinase 1) kinase phosphorylates both ubiquitin and the E3 ubiquitin ligase PRKN (Parkin RBR E3 ubiquitin ligase), also known as PARKIN. This event recruits PRKN to the mitochondria, thus amplifying ubiquitylation signal. Here we report that miR-218 targets PRKN and negatively regulates PINK1/PRKN-mediated mitophagy. Overexpr
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Fan, Kuan, Pengzhi Hu, Chengyuan Song, et al. "Novel Compound Heterozygous PRKN Variants in a Han-Chinese Family with Early-Onset Parkinson’s Disease." Parkinson's Disease 2019 (December 23, 2019): 1–6. http://dx.doi.org/10.1155/2019/9024894.

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Genetic factors are thought to play an important role in the pathogenesis of Parkinson’s disease (PD), particularly early-onset PD. The PRKN gene is the primary disease-causing gene for early-onset PD. The details of its functions remain unclear. This study identified novel compound heterozygous variants (p.T240K and p.L272R) of the PRKN gene in a Han-Chinese family with early-onset PD. This finding is helpful in the genetic diagnosis of PD and also the functional research of the PRKN gene.
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Li, Dunhui, May T. Aung-Htut, Kristin A. Ham, Sue Fletcher, and Steve D. Wilton. "A Splice Intervention Therapy for Autosomal Recessive Juvenile Parkinson’s Disease Arising from Parkin Mutations." International Journal of Molecular Sciences 21, no. 19 (2020): 7282. http://dx.doi.org/10.3390/ijms21197282.

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Parkin-type autosomal recessive juvenile-onset Parkinson’s disease is caused by mutations in the PRKN gene and accounts for 50% of all autosomal recessive Parkinsonism cases. Parkin is a neuroprotective protein that has dual functions as an E3 ligase in the ubiquitin–proteasome system and as a transcriptional repressor of p53. While genomic deletions of PRKN exon 3 disrupt the mRNA reading frame and result in the loss of functional parkin protein, deletions of both exon 3 and 4 maintain the reading frame and are associated with a later onset, milder disease progression, indicating this particu
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van Bree, Elisabeth J., Soufyan Lakbir, Carmen Rubio-Alarcón, et al. "Abstract 401: The impact of DNA structural variants on PRKN gene function and colorectal cancer pathogenesis." Cancer Research 84, no. 6_Supplement (2024): 401. http://dx.doi.org/10.1158/1538-7445.am2024-401.

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Abstract Background: Cancer is caused by somatic DNA alterations, such as single nucleotide variants, somatic copy number alterations and structural variants (SVs). PRKN is among the genes most frequently affected by SVs in colorectal cancer (CRC), with 37% of primary cancers and 56% of metastatic lesions having focal deletions in PRKN. PRKN encodes the E3 ubiquitin ligase Parkin, which regulates the biological activity and degradation of substrates via post-translational modifications. The genomic location of PRKN is within a common fragile site. Therefore, it remains unclear whether the high
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Trần, Tín Nghĩa, Vân Khánh Trần, Huy Thịnh Trần, Hoàng Việt Nguyễn, Thanh Thùy Phí та Lê Anh Tuấn Phạm. "XÁC ĐỊNH ĐỘT BIẾN TRÊN GEN PINK1 VÀ GEN PRKN Ở BỆNH NHÂN PARKINSON". Tạp chí Y Dược học Cần Thơ, № 72 (25 березня 2024): 75–81. http://dx.doi.org/10.58490/ctump.2024i72.2419.

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Đặt vấn đề: Bệnh Parkinson là bệnh thoái hóa thần kinh thường gặp ở người cao tuổi, chỉ sau Alzheimer. Bệnh là do ở phần đặc chất đen có hiện tượng thoái hóa chọn lọc của các tế bào dopaminergic, hậu quả là giảm hàm lượng dopamin, ảnh hưởng sự dẫn truyền các tín hiệu thần kinh cho quá trình co cơ. Các kỹ thuật sinh học phân tử đã chứng minh yếu tố di truyền đóng vai trò quan trọng trong tiến trình của bệnh Parkinson. Mục tiêu nghiên cứu: Xác định đột biến trên gen PINK1 và gen PRKN ở bệnh nhân Parkinson bằng phương pháp giải trình tự gen Sanger. Đối tượng và phương pháp nghiên cứu: Nghiên cứu
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Dissertations / Theses on the topic "PRKN"

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TREZZI, ILARIA. "INVESTIGATING GLUTAMATE TOXICITY ASSOCIATED TO PARK2 MUTATIONS IN PRE-CLINICAL MODELS OF PARKINSON¿S DISEASE." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/925250.

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ABSTRACT Background: Park2 mutations cause Autosomal Recessive Juvenile Parkinsonism (ARJP), characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Park2 encodes for a ubiquitin-ligase protein whose mutation upregulates Gluk2, a subunit of the glutamate kainate receptor (KAR), expressed in SNpc neurons. Park2 is highly expressed also in astrocytes and KARs upregulation may induce excitotoxicity both in DA neurons and glia, leading to an early synaptopathy, neuroinflamation and neurodegeneration. Aims and Objectives: 1. To generate Park2 ind
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Miele, Gino. "Analyses of gene expression in Prn-p+/+ and Prn-p-/- mice." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/22489.

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The Transmissible Spongiform Encephalopathies (TSEs) are a group of invariably fatal neurodegenerative diseases which manifest in a broad range of species. At present, the causative agent of the TSEs remains unknown. The only disease-specific macromolecule identified to date is a protease-resistant abnormal isoform (PrP<SUP>Sc</SUP>) of a protease sensitive normal host-encoded glycoprotein (PrP<SUP>C</SUP>). Despite the discovery of PrP<SUP>C</SUP> more than a decade ago, the precise normal physiological function of this protein remains unknown. PrP<SUP>C</SUP> is highly conserved across all s
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Olivera, Espinoza César Augusto. "PRK: excimer láser experiencia hospitalaria." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2003. https://hdl.handle.net/20.500.12672/2018.

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El presente trabajo tiene por meta realizar un estudio prospectivo de un grupo de pacientes con diversos grados de Ametropia Miopica, protocolizandolos y sometiéndose a cirugía refractiva fotoablativa. PRK; no LASIK por no contar con el Microkeratomo. El protocolo ha sido diseñado para así uniformizar la elección de los pacientes y poder interpretar fidedignamente los resultados. Como es bien sabido el porcentaje de vicios de refracción. es muy atto en la población en general por lo tanto la necesidad de corregirlos con la tecnología actual es cada vez más imperante.<br>Tesis de segunda espec
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Couto, Gustavo de Alvarenga. "Efeito do ângulo da fieira na geometria e propriedades mecânicas de barras trefiladas." Universidade Federal de Minas Gerais, 2011. http://hdl.handle.net/1843/PRCN-8P9GMW.

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In cold drawing of metallic bars most of the plastic flow is caused by compressive forces which arise from the reaction of the metal to the die. Due to the characteristics of the process this flow is not homogeneous along the cross section of the bar and is influenced by the die geometry. This inhomogeneous deformation generates residual stresses in the bars, which can produce a change in size and straightness during subsequent processes of cutting, grinding and heat treatment. This work presents an analysis of the influence of the die geometry and number of drawing passes on the final geometr
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Bezerra, Augusto Cesar da Silva. "Concreto com fibras curtas de aço submetido a alta temperatura." Universidade Federal de Minas Gerais, 2012. http://hdl.handle.net/1843/PRCN-8TEFUF.

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This study investigated conventional concrete with the addition of short fibers of steel in normal condition and after have been subjected to high temperature. The fibers were characterized by microscopy and mechanical tensile tests. The constituents of the cementitious composites were characterized. To evaluate the interaction between fibers and the cement matrix, were fabricated prismatic specimen partitioned with 40x40x160mm, the halves were connected by three fibers in the direction longititudinal and they were tested at flexion. To evaluate the cementitious composites reinforced, was mold
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Sandgren, Daniel. "Test av brunnslock i komposit enligt standard prEN 124." Thesis, Umeå universitet, Institutionen för tillämpad fysik och elektronik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100025.

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Standarder finns i alla möjliga delar av samhället. De används för att säkerställa kvalité, säkerhet och effektivitet. Standarden för hur brunnslock produceras och designas heter prEN 124. Den har förändrats och det är grunden till detta projekt.Brunnspecialisten AB, ett företag i Holmsund, är projektets beställare och har behov av att godkänna sina brunnslock enligt prEN 124 för fortsatt försäljning.Projektets arbetsmoment kan delas in i tre saker. För det första att tolka vilka tester som behöver utföras för att godkänna brunnslock enligt prEN 124. För det andra definiera hur de ska utföras
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Nejedlý, Zdeněk. "Mechanické a technologické vlastnosti duplexních ocelí v závislosti na hodnotě PREN." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-231634.

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This thesis deals with stainless austenitic-ferritic (duplex) steels and their mechanical and technological properties. The first part focuses on introducing these high-alloy materials. The second part describes the influence of chemical composition on the mechanical properties, technological properties and steel structure. There was also observed the effect of heat treatment and steel melting under reduced pressure.
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Uliniuc, Ancuta. "Modificări chimice ale polizaharidelor şi ale hidrogelurilor lor prin procedeul "click chemistry"." Phd thesis, Université Claude Bernard - Lyon I, 2011. http://tel.archives-ouvertes.fr/tel-00834679.

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Ce travail a pour objet l'obtention et la caractérisation de nouveaux copolymères amphiphiles et d'hydrogels à hydrophilie contrôlée, à partir de polymères naturels, avec comme utilisations potentielles la vectorisation de principes actifs. En conséquence, il est donc nécessaire que les polymères utilisés pour l'obtention de ces architectures répondent à un certain nombre de contraintes, notamment être non-toxiques, biocompatibles et biodégradables. Pour ces raisons, on retient le plus souvent comme matériaux de départ des polymères naturels, en particulier les polysaccharides. Quelques polymè
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Stanciu, Nicoleta Doriana. "Compozite polimer-organice şi polimer-anorganice obţinute prin polimerizare radicalică „in situ”." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10006.

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Ce travail porte sur l'obtention et la caractérisation de composites polymères à charges organiques et inorganiques obtenus par polymérisation radicalaire in situ de monomères dans une matrice organique de type cellulose ou inorganique de type silicate. Avec la cellulose, les monomères retenus sont d'abord des dérivés vinyliques de type acide (méth)acrylique et de comonomères tels que l'anhydride maléique, le styrène et le chlorométhylstyrène. Les produits sont caractérisés notamment par ATG et XRD. La conductivité électrique de ces composites en fonction de leur gonflement a été étudiée. La c
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Netto, Marcelo Vieira. "Efeitos do uso tópico da mitomicina C na prevenção e tratamento da opacidade corneana em coelhos submetidos à ceratectomia fotorrefrativa." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5149/tde-20022009-132232/.

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Objetivos: Determinar os efeitos celulares e o mecanismo de ação da mitomicina C tópica na prevenção e tratamento da opacidade corneana em coelhos submetidos à ceratectomia fotorrefrativa (PRK). Métodos: Foram submetidos à cirurgia de PRK 224 coelhos para correção de -9 dioptrias esféricas, associada à aplicação de mitomicina C tópica ou solução salina balanceada. O nível de opacidade corneana foi avaliado por meio de análise à lâmpada de fenda. Os animais foram sacrificados quatro horas, 24 horas, quatro semanas e seis meses após a cirurgia. A análise imunohistoquímica foi realizada com as té
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Books on the topic "PRKN"

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Andrew, Davies. Prin. French, 1989.

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Oprea, Ștefan. Prin teatre și prin ani. Editura Artes a Universității de Arte "George Enescu", 2011.

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Lily, Anamika Huqu. Bishwabhara pran. Anindya, 1991.

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Jones, E. Breeze. Adar prin. Gwasg Dwyfor, 1985.

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Khanpuri, Jagjit Singh. Pran Sangli. Panjabi University, 1991.

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Ka, Dr. Dr. Pran. NSB Grupo Editorial, 2017.

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Tănăsescu, Simona. Prin telescop. Semne, 2015.

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John, Arwel. Anifeiliaid prin. Canolfan Astudiaethau Addysg Prifysgol Cymru, 2003.

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Goldflam, Arnošt. Vratká prkna. Větrné mlýny, 2012.

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Petre, Zoe, 1940- writer of forword, ed. Prin perdea. Polirom, 2012.

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Book chapters on the topic "PRKN"

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Rossi, Scipione. "Corneal Biomechanical Effects of Surface Ablation Compared With LASIK Using Microkeratome or Femtosecond Laser." In PRK. CRC Press, 2024. http://dx.doi.org/10.1201/9781003525950-11.

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Buratto, Lucio, Stephen G. Slade, Sebastiano Serrao, and Marco Lombardo. "Photorefractive Keratectomy." In PRK. CRC Press, 2024. http://dx.doi.org/10.1201/9781003525950-4.

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Vinciguerra, Paolo, Elena Albé, and R. Vinciguerra. "Smoothing in Refractive Surgery." In PRK. CRC Press, 2024. http://dx.doi.org/10.1201/9781003525950-9.

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Buratto, Lucio, Stephen G. Slade, Sebastiano Serrao, and Marco Lombardo. "Optical and Mechanical Properties of the Cornea." In PRK. CRC Press, 2024. http://dx.doi.org/10.1201/9781003525950-3.

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Buratto, Lucio, Steven G. Slade, Sebastiano Serrao, and Marco Lombardo. "Conclusions." In PRK. CRC Press, 2024. http://dx.doi.org/10.1201/9781003525950-5.

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Buratto, Lucio, Steven G. Slade, Sebastiano Serrao, and Marco Lombardo. "Attachments." In PRK. CRC Press, 2024. http://dx.doi.org/10.1201/9781003525950-6.

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Khalifa, Mounir A., and Waleed A. Allam. "Photorefractive Keratectomy Enhancement Following Previous Radial Keratotomy and LASIK." In PRK. CRC Press, 2024. http://dx.doi.org/10.1201/9781003525950-8.

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Buratto, Lucio, Stephen G. Slade, Sebastiano Serrao, and Marco Lombardo. "The Corneal Surface." In PRK. CRC Press, 2024. http://dx.doi.org/10.1201/9781003525950-2.

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Kanellopoulos, Anastasios John. "The Athens Protocol PRK and CXL." In PRK. CRC Press, 2024. http://dx.doi.org/10.1201/9781003525950-12.

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Vinciguerra, Paolo, Elena Albé, and R. Vinciguerra. "How to Perform Custom Ablation." In PRK. CRC Press, 2024. http://dx.doi.org/10.1201/9781003525950-10.

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Conference papers on the topic "PRKN"

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Haudet, Santiago Sosa, Martín A. Rodríguez, Ricardo M. Carranza, and Raul B. Rebak. "Effect of Alloy Composition on the Crevice Corrosion Resistance of Nickel Alloys." In CORROSION 2012. NACE International, 2012. https://doi.org/10.5006/c2012-01455.

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Abstract Nickel base alloys are considered among candidate materials for engineered barriers of nuclear repositories. The localized corrosion resistance is a determining factor in the materials selection for this application. This work compares the crevice corrosion resistance of selected nickel base alloys, namely N06625, N06030, N06035, N06022, N07022 and N10362. The crevice corrosion repassivation potential (ER,CREV) of the tested alloys was determined by the Potentiodynamic-Galvanostatic-Potentiodynamic method. The testing temperature was 60°C and the chloride concentrations used were 0.1
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Mori, G. "User’S View of Pitting Corrosion." In CORROSION 2004. NACE International, 2004. https://doi.org/10.5006/c2004-04304.

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Abstract Pitting resistance equivalent number (PREN or PRE) has been introduced by suppliers as a tool for comparing stainless steels for their relative resistance to pitting. The user of stainless steels has only a very limited knowledge for PREN. Important questions for users are: “Which steel quality is necessary to be applied in a given environment?”, “Up to which temperature can a given stainless steel be applied in a certain environment?” or “Can the plant be operated with an increased chloride concentration up to … ppm?. To answer this questions based on literature data two formulas are
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Valle, Luísa Vicari do, Eduarda Marques de Azevedo, and José Antônio da Cunha Ponciano Gomes. "Materials Selection of Corrosion Resistant Alloys in Produced Water Based in Electrochemical Techniques and Chemical Composition Index." In CORROSION 2019. NACE International, 2019. https://doi.org/10.5006/c2019-13353.

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Abstract Produced water can be much more aggressive in terms of corrosion than sea water, presenting high levels of chloride and carbon dioxide. In addition to bring corrosion risks for oil and gas production systems, it contains harmful components to environment. This way, it is crucial a materials selection that guarantees a good performance of produced water treatment systems. Although there are many studies evaluating the strength of stainless steels in seawater medium, resistance of these materials in produced water has not been fully investigated. Pitting Resistance Equivalent Number (PR
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Ayers, Tatiana R., Manuel P. Marya, and Dean Lauppe. "On the Relative Sulfide Stress Cracking Susceptibility of Cr-Mn Austenitic Steels and Comparisons to 17-4PH." In CORROSION 2018. NACE International, 2018. https://doi.org/10.5006/c2018-11163.

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Abstract In searching for plausible replacements of 17-4PH (UNS S17400) HH1150 for selected oilfield applications where the presence of reservoir fluid is a possibility, a series of NACE TM0177 Tensile Test Method A tests were conducted on various commercially available chromium-manganese austenitic stainless steels as well as 17-4PH in the 110ksi-to-130ksi yield strength range (34 - 35 HRC max). Complementarily, microstructure analyses and electrochemical tests, among other standard tests, were applied to all alloys for comparison purposes and were used to explain the sulfide stress cracking
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Hibner, E. L., C. S. Tassen, and J. W. Skogsberg. "Effect of Alloy Nickel Content vs. PREN on the Selection of Austenitic Oil Country Tubular Goods for Sour Gas Service." In CORROSION 1998. NACE International, 1998. https://doi.org/10.5006/c1998-98106.

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Abstract Traditionally, in the selection of Oil Country Tubular Goods (OCTG) for sour gas service, Corrosion Resistant Alloys (CRA’s) are screened first by their pitting resistance equivalent number (PREN) and then by environmental cracking data generated in sour brine environments. The theory is that a pit occurs first, which provides a stress-riser for initiation of anodic chloride stress corrosion cracking (SCC). Among the primary CRA’s currently used in the cold worked condition for OCTG in sour gas wells are alloy 825 (UNS N08825) and alloy 28 (UNS N08028). While alloy 28 has a somewhat h
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Grubb, John F., Bahri Ozturk, and John J. Dunn. "An Enhanced Superaustenitic Alloy for Use in Severe Marine Service." In CORROSION 2008. NACE International, 2008. https://doi.org/10.5006/c2008-08260.

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Abstract Increasing the Cr+Mo+N content of N08367 alloy to near the specification maxima produces a material with a PREN greater than 50. This enhanced iron-based alloy, which will be designated in this work as N08367+, has a composition and properties approaching that of the 7Mo alloys, but is produced by more conventional stainless steel manufacturing techniques. This high PREN provides enhanced corrosion performance in many environments. Use of N08367+ material in seawater temperatures up to 50°C, well beyond the normal maximum limit of 35°C for conventional 6Mo alloys, has been proposed. C
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Menon Poornima, Jayadev, Sambin Sara, Criniere-Boizet Baptiste, et al. "Genotype-phenotype correlation in PRKN-associated Parkinson’s disease." In Association of British Neurologists: Annual Meeting Abstracts 2023. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jnnp-2023-abn.19.

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Branchi, V., L. Esser, C. Boden, et al. "Umfassende Expressionsanalyse der Gene PRKN, PINK1 und GLUT1 (Gewebe, Organoidmodell, in silico) zeigt deren Biomarkerpotential im Cholangiokarzinom." In DGVS Digital: BEST OF DGVS. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1716277.

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Wu, Wenfei, Li Erran Li, Aurojit Panda, and Scott Shenker. "PRAN." In HotNets-XIII: The 13th ACM Workshop on Hot Topics in Networks. ACM, 2014. http://dx.doi.org/10.1145/2670518.2673865.

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Lozinschii, Mariana, Alina Cutcovschii-Mustuc, and Maria Sofronii. "Multiplicarea trandafirului prin virtroculturi." In International Scientific Symposium "Advanced Biotechnologies - Achievements and Prospects". Institute of Genetics, Physiology and Plant Protection, Republic of Moldova, 2020. http://dx.doi.org/10.53040/9789975566957.40.

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Reports on the topic "PRKN"

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Dai, Wei. Investigation of the Candidate Tumor Suppressor Gene prk in Prostate Cancer. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada405508.

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Dai, Wei, Qi Wang, and Suqing Xie. Investigation of the Candidate Tumor Suppressor Gene prk in Prostate Cancer. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada413339.

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Savu, Alin, Bogdan Pălici, Maria Trifon, and Cristian Georgescu. Dinamica infrastructurii și accesul la bibliotecile publice. Institutul Național pentru Cercetare și Formare Culturală, 2023. http://dx.doi.org/10.61789/pub.cdi.bibp.23.

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"Această publicație prezintă dinamica din ultimele decenii a unor aspecte esențiale privind rețeaua bibliotecilor publice din România. Primul capitol ilustrează distribuția teritorială a bibliotecilor publice pe un suport cartografic interactiv cu dezagregare până la nivel de localitate. Ulterior, capitolul prezintă o comparație dinamică a evoluției bibliotecilor publice la nivelul județelor în perioada 1995-2022. În continuare, capitolul al doilea abordează interactiv subiectul complementar al accesului populației la biblioteca publică din localitatea de rezidență. În ultimele trei decenii, n
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Thomashow, Linda, Leonid Chernin, Ilan Chet, David M. Weller, and Dmitri Mavrodi. Genetically Engineered Microbial Agents for Biocontrol of Plant Fungal Diseases. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7696521.bard.

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The objectives of the project were: a) to construct the site-specific integrative expression cassettes carrying: (i) the chiA gene for a 58-kDa endochitinase, (ii) the pyrrolnitrin biosynthesis operon, and (iii) the acdS gene encoding ACC deaminase; b) to employ these constructs to engineer stable recombinant strains with an expanded repertoire of beneficial activities; c) to evaluate the rhizosphere competence and antifungal activity of the WT and modified strains against pathogenic fungi under laboratory and greenhouse conditions; and d) to monitor the persistence and impact of the introduce
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Miller, Robert E., Thompson II, Baldwin William T., et al. Prospective Evaluation of Mesopic Night Vision and Night Vision Goggle Visual Acuity After Photorefractive Keratectomy (PRK). Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada435075.

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Tsai, Tsung-Hsien, Ling-Shuo Chang, and Jui-Hung Hsu. Longitudinal Changes in Epithelial Thickness After SMILE, FS-LASIK, and Transepithelial PRK: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2025. https://doi.org/10.37766/inplasy2025.1.0085.

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วรรณลภากร, ณศมน. ผลระยะยาวของการให้วัคซีนไอกรนชนิดเต็มเซลล์ หรือไร้เซลล์ในเด็กทารกที่คลอดจากมารดาที่ได้รับวัคซีนไอกรนขณะตั้งครรภ์. คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2018. https://doi.org/10.58837/chula.res.2018.26.

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Background: Pertussis vaccination in pregnant women is a strategy currently recommended to foster passive maternal immunity and minimize severe complications from pertussis in not yet completely vaccinated infants. However, the potential interference of maternal antibodies on the development of infant antibody responses induced by childhood whole cell pertussis (wP) and acellular pertussis (aP) vaccination is not well-defined. Methods: This randomized controlled trial (NCT02408926) followed healthy term infants born to tetanus diphtheria acellular pertussis (Tdap)-vaccinated mothers at a terti
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Coleman, M. D., and L. Bonsignore. M4R Project - consultancy for element materials technology: summary of consultation regarding implementation of measurement methods CEN/TS 17337:2019 and prEN 16429 for monitoring of pollutants from industrial processes regulated under the Industrial Emissions Directive. National Physical Laboratory, 2021. http://dx.doi.org/10.47120/npl.env36.

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Declarația Munster referitor la principiile eticii cercetării și integrității cercetării. Munster Technological University, 2025. https://doi.org/10.34719/eauj5369.

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"&lt;p&gt;INGENIUM este o alianță de zece instituții de învățământ superior din zece țări europene. Această universitate europeană urmărește să permită fiecărui membru al rețelei să ofere programe de studiu și calificare de înaltă calitate, cu componente digitale care sunt partajate în cadrul Alianței INGENIUM.&lt;/p&gt; &lt;p&gt;În instituțiile de învățământ superior se pune un accent din ce în ce mai mare pe promovarea bunelor practici de cercetare în toate aspectele cercetării1,2, de la cercetarea fundamentală la cercetarea aplicată la comercializare. Etica cercetării (EC) și integritatea c
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