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Journal articles on the topic 'Probiotic formulation'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Taverniti, Valentina, Ranjan Koirala, Alessandro Dalla Via, et al. "Effect of Cell Concentration on the Persistence in the Human Intestine of Four Probiotic Strains Administered through a Multispecies Formulation." Nutrients 11, no. 2 (2019): 285. http://dx.doi.org/10.3390/nu11020285.

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Studies devoted to evaluating the outcome of different doses of probiotics are very limited, especially for multistrain formulations. In this context, we performed an intervention study that aimed to compare the effect of the administration of two doses (7 billion and 70 billion bacterial cells) of a multistrain probiotic formulation on the persistence of the four probiotic strains that were present in the product in the fecal samples collected from healthy subjects. The overall persistence of the probiotic strains was significantly higher for the 70 billion formulation than for the 7 billion

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2

Kinvan, Emine, and Tugba Ozdal. "IMPROVED DOMESTIC PROBIOTIC ENERGY BAR DESIGN BY USING SENSORY ANALYSIS METHODS." Latin American Applied Research - An international journal 52, no. 4 (2022): 387–92. http://dx.doi.org/10.52292/j.laar.2022.964.

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Today, the relationship between health and nutrition is gaining more importance. Studies have shown that probiotics have significant effects on health and can be used to prevent various diseases. However, the consumption of probiotic products is still not sufficient. Therefore, probiotic products should be multiplied and disseminated. In this study, it was aimed to develop a probiotic product with high nutritional value and energy level by using probiotic oatmeal, hazelnut, peanut, pistachio, almond, walnut and chocolate. Products produced as probiotic energy bar are designed in three differen

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Urcan, Adriana Cristina, Adriana Dalila Criste, Otilia Bobiș, Mihaiela Cornea-Cipcigan, Alexandru-Ioan Giurgiu, and Daniel Severus Dezmirean. "Evaluation of Functional Properties of Some Lactic Acid Bacteria Strains for Probiotic Applications in Apiculture." Microorganisms 12, no. 6 (2024): 1249. http://dx.doi.org/10.3390/microorganisms12061249.

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This study evaluates the suitability of three lactic acid bacteria (LAB) strains—Lactiplantibacillus plantarum, Lactobacillus acidophilus, and Apilactobacillus kunkeei—for use as probiotics in apiculture. Given the decline in bee populations due to pathogens and environmental stressors, sustainable alternatives to conventional treatments are necessary. This study aimed to assess the potential of these LAB strains in a probiotic formulation for bees through various in vitro tests, including co-culture interactions, biofilm formation, auto-aggregation, antioxidant activity, antimicrobial activit

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Wang, Anyi, and Qixin Zhong. "Drying of probiotics to enhance the viability during preparation, storage, food application, and digestion: A review." Comprehensive Reviews in Food Science and Food Safety 23, no. 1 (2023): 1–30. http://dx.doi.org/10.1111/1541-4337.13287.

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AbstractFunctional food products containing viable probiotics have become increasingly popular and demand for probiotic ingredients that maintain viability and stability during processing, storage, and gastrointestinal digestions. This has resulted in heightened research and development of powdered probiotic ingredients. The aim of this review is to overview the development of dried probiotics from upstream identification to downstream applications in food. Free probiotic bacteria are susceptible to various environmental stresses during food processing, storage, and after ingestion, necessitat

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Pranay, Chaurpagar*1 Prathamesh Joshi2 Prathamesh Deshmane3 Pratiksha Mundhe4 Priya Dandekar5 Mayuri Zore6 Shivshankar Nagrik7 Janhavi Gadhe8 Mohini Kale9. "A Review on Probiotic-Infused Herbal Vanishing Cream for Skin Microbiome Balance." International Journal of Scientific Research and Technology 2, no. 3 (2025): 112–25. https://doi.org/10.5281/zenodo.14977847.

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The human skin microbiome plays a crucial role in maintaining skin health, protecting against environmental stressors, and regulating immune responses. Disruptions in microbial balance can contribute to various dermatological disorders, necessitating innovative skincare solutions. This review explores the potential of probiotic-infused herbal vanishing creams as a novel approach to promoting skin microbiome balance. Traditional vanishing creams are lightweight, non-greasy emulsions primarily designed for hydration and texture enhancement. However, they lack active components that support micro

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Maoloni, Antonietta, Federica Cardinali, Vesna Milanović, et al. "Exploratory Study for Probiotic Enrichment of a Sea Fennel (Crithmum maritimum L.) Preserve in Brine." Foods 11, no. 15 (2022): 2219. http://dx.doi.org/10.3390/foods11152219.

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Considering the increasing consumer demand for vegan and vegetarian health foods, different vegetables have been already exploited to produce non-dairy probiotic foods. In addition to being rich in bioactive compounds, sea fennel (Crithmum maritimum L.), also known as rock samphire, represents a valuable candidate in the production of probiotic-enriched foods, and, to the authors’ knowledge, it has not yet been explored as carrier for probiotics. Hence, the present study was aimed at evaluating the survival of a commercially available probiotic formulation, SYNBIO®, and Lactiplantibacillus pla

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Oliva, Alessandra, Maria Claudia Miele, Massimiliano De Angelis, et al. "Antibacterial Effectiveness of Fecal Water and In Vitro Activity of a Multi-Strain Probiotic Formulation against Multi-Drug Resistant Microorganisms." Microorganisms 8, no. 3 (2020): 332. http://dx.doi.org/10.3390/microorganisms8030332.

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Introduction: Intestinal colonization with multi-drug resistant (MDR) microorganisms is a consequence of antimicrobial-induced gut dysbiosis. Given the effect of probiotics in modulating gut microbiota, the aim of the study was to investigate whether the ingestion of high concentration multi-strain probiotic formulation would change the antibacterial activity of the feces against clinical strains of MDR microorganisms. The corresponding in vitro antibacterial activity was also investigated. Materials/Methods: The feces of healthy donors (n = 6) were analyzed before and after a 7-day dietary su

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Gullifa, Giuseppina, Roberta Risoluti, Cristina Mazzoni, et al. "Microencapsulation by a Spray Drying Approach to Produce Innovative Probiotics-Based Products Extending the Shelf-Life in Non-Refrigerated Conditions." Molecules 28, no. 2 (2023): 860. http://dx.doi.org/10.3390/molecules28020860.

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Recently, there has been a growing interest in producing functional foods containing encapsulated probiotic bacteria due to their positive effects on human health. According to their perceived health benefits, probiotics have been incorporated into a range of dairy products, but the current major challenge is to market new, multicomponent probiotic foods and supplements. Nevertheless, only a few products containing encapsulated probiotic cells can be found as non-refrigerated products. In this work, spray drying technology was investigated in order to produce an innovative nutraceutical formul

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Grumet, Lukas, Yorick Tromp, and Verena Stiegelbauer. "The Development of High-Quality Multispecies Probiotic Formulations: From Bench to Market." Nutrients 12, no. 8 (2020): 2453. http://dx.doi.org/10.3390/nu12082453.

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Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. To date, there is an increasing number of commercially available products containing probiotics on the market. Probiotics have been recommended by health care professionals for reasons ranging from their long-term immunomodulatory effects to proven benefits in the management of different health conditions. For probiotic products, there are several important aspects that determine the success rate of the development from bench to market. The aim of this review is to explore how t

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10

Govaert, Marlies, Chloë Rotsaert, Chelsea Vannieuwenhuyse, et al. "Survival of Probiotic Bacterial Cells in the Upper Gastrointestinal Tract and the Effect of the Surviving Population on the Colonic Microbial Community Activity and Composition." Nutrients 16, no. 16 (2024): 2791. http://dx.doi.org/10.3390/nu16162791.

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Many health-promoting effects have been attributed to the intake of probiotic cells. However, it is important that probiotic cells arrive at the site of their activity in a viable state in order to exert their beneficial effects. Careful selection of the appropriate probiotic formulation is therefore required as mainly the type of probiotic species/strain and the administration strategy may affect survival of the probiotic cells during the upper gastrointestinal (GIT) passage. Therefore, the current study implemented Simulator of the Human Microbial Ecosystem (SHIME®) technology to investigate

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Kober, A. K. M. Humayun, Muhammad Shahid Riaz Rajoka, Hafiza Mahreen Mehwish, Julio Villena, and Haruki Kitazawa. "Immunomodulation Potential of Probiotics: A Novel Strategy for Improving Livestock Health, Immunity, and Productivity." Microorganisms 10, no. 2 (2022): 388. http://dx.doi.org/10.3390/microorganisms10020388.

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Over the past decade, the use of probiotics as feed supplements in animal production has increased considerably due to the ban on antibiotic growth promoters in livestock. This review provides an overview of the current situation, limitation, and prospects for probiotic formulations applied to livestock. Recently, the use of probiotics in livestock has been suggested to significantly improve their health, immunity, growth performance, nutritional digestibility, and intestinal microbial balance. Furthermore, it was reported that the use of probiotics in animals was helpful in equilibrating thei

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Nurzeba, M. Bepari* Ketura Kambampaty. "Development of Novel Probiotic Formulation using Lactobacillus acidophilus." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 1036–45. https://doi.org/10.5281/zenodo.14640687.

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This study aimed to develop stable room-temperature granules of Lactobacillus acidophilus (NCIM 2285) probiotics while optimizing granule formulation to maximize viable cell count after 2 hours of incubation in an acidic medium. Spray drying and tray drying techniques were employed to prepare probiotic powders, offering cost-effective alternatives to the expensive freeze-drying method. The granules were evaluated for antioxidant activity and antimicrobial properties. Antioxidant activity was assessed through in vitro methods, including the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical sca

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Silva e Alves, Adriana, Leila Spadoti, Patrícia Zacarchenco, and Fabiana Trento. "Probiotic Functional Carbonated Whey Beverages: Development and Quality Evaluation." Beverages 4, no. 3 (2018): 49. http://dx.doi.org/10.3390/beverages4030049.

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Whey proteins have excellent nutritional characteristics due to their levels of essential amino acids with high bioavailability. However, they have a high biochemical oxygen demand (BOD) and a considerable polluting potential, thus, food manufacturers have opted to add whey to food formulations. The demand for beverages, containing vitamins, probiotics, prebiotics, minerals, and bioactive compounds (antioxidants) with health benefits, has increased and driven market growth. Therefore, this study aimed to develop a probiotic functional carbonated beverage from cheese whey and evaluate its micro

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Ökay, Utku, Kadir Çoral, Tuğçe Çetinkaya, Pelin Timur, and Dilara Konuk Takma. "Formulation and Evaluation of Lactose-Free Probiotic Milk Beverage with Added Dried Figs." Orclever Proceedings of Research and Development 5, no. 1 (2024): 285–93. https://doi.org/10.56038/oprd.v5i1.553.

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Digestive issues have become widespread due to factors such as imbalanced nutrition and the increase in fast-food consumption. The foods which are available to meet the daily probiotic consumption of individuals are limited. To overcome this nutritional need through the consumed foods, a newly formulated food product called "lactose-free milk beverage with dried fig and probiotic supplements" has been developed. It is formulated with lactose-free milk to be suitable for consumption by all individuals. Dried figs produced and exported in our country are functional ingredients not only for their

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Sardar, Dipankar, Istiaq Morol, Johra Bari, Amalan Sarkar, and Adnan Habib. "Optimization of cryoprotectants and storage temperatures for preserving viability and probiotic properties of lyophilized bacterial strains from chicken gut." PLOS One 20, no. 7 (2025): e0328216. https://doi.org/10.1371/journal.pone.0328216.

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Probiotics, particularly strains from the genera Bacillus, Lactobacillus, and Staphylococcus, play a vital role in gut health, immune modulation, and pathogen inhibition. However, environmental stressors during storage often compromise their long-term viability and probiotic functionality. By examining how lyophilization affects the viability and probiotic functionality of certain strains of Bacillus, Lactobacillus, and Staphylococcus, this study sought to understand how storage conditions and protective agents affect bacterial survival and important probiotic characteristics. The bacterial st

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Sun, Weizhe, Quang D. Nguyen, Gizella Sipiczki, et al. "Microencapsulation of Lactobacillus plantarum 299v Strain with Whey Proteins by Lyophilization and Its Application in Production of Probiotic Apple Juices." Applied Sciences 13, no. 1 (2022): 318. http://dx.doi.org/10.3390/app13010318.

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The viability of probiotics is strictly influenced by the production, storage, and digestion, while microencapsulation is a technology that can protect them against harsh environments. In this study, the impact of different core-to-wall ratios and wall material formulations on physical properties and the cell number of the microcapsules were investigated. The samples with core-to-wall ratio 1:1 have a significantly higher cell number, encapsulation efficiency, and bulk density than samples with core-to-wall ratio 1:1.5. The yields of the encapsulation method were changes in the opposite direct

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Olson, Jacob K., Jason B. Navarro, Jacob M. Allen, et al. "An enhancedLactobacillus reuteribiofilm formulation that increases protection against experimental necrotizing enterocolitis." American Journal of Physiology-Gastrointestinal and Liver Physiology 315, no. 3 (2018): G408—G419. http://dx.doi.org/10.1152/ajpgi.00078.2018.

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One significant drawback of current probiotic therapy for the prevention of necrotizing enterocolitis (NEC) is the need for at least daily administration because of poor probiotic persistence after enteral administration, increasing the risk of the probiotic bacteria causing bacteremia or sepsis if the intestines are already compromised. We previously showed that the effectiveness of Lactobacillus reuteri ( Lr) in preventing NEC is enhanced when Lr is grown as a biofilm on the surface of dextranomer microspheres (DM). Here we sought to test the efficacy of Lr administration by manipulating the

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Rutten, N. B. M. M., I. Besseling-Van der Vaart, M. Klein, S. De Roock, A. Vlieger, and G. Rijkers. "In vitro assessment of the immunomodulatory effects of multispecies probiotic formulations for management of allergic diseases." Beneficial Microbes 2, no. 3 (2011): 183–92. http://dx.doi.org/10.3920/bm2011.0012.

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Modulation of the composition of the intestinal microbiota with probiotics could possibly offer a way of prevention or management of allergic diseases. The objective of this study was to determine the immunomodulating effects of various multispecies probiotic combinations in vitro, as preamble to application in vivo. Multispecies probiotic combinations were formulated and tested for their effects on in vitro cytokine production by human mononuclear cells and were compared to products that already have shown beneficial effects in vivo. All 4 tested combinations of probiotics showed a 40-71% dec

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Meijerink, M., A. Mercenier, and J. M. Wells. "Challenges in translational research on probiotic lactobacilli: from in vitro assays to clinical trials." Beneficial Microbes 4, no. 1 (2013): 83–100. http://dx.doi.org/10.3920/bm2012.0035.

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Beneficial effects of certain probiotic strains have been established in the treatment and prevention of various immune and intestinal disorders in humans, including allergic diseases, chronic inflammatory diseases and diarrhoea. The proposed mechanisms underlying the immunomodulatory effects of probiotics in humans are not understood in precise detail but include enhancement of intestinal barrier function, altered epithelial signalling, competition with pathogens and effects on immune cells and immunity depending on the probiotic strain. The publication of controversial or inconclusive probio

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Akhavan, Ghazaleh, and Rana Imani. "Investigation of drug release systems for application Probiotic Delivery." International Journal of New Findings in Health and Educational Sciences (IJHES) 1, no. 2 (2023): 88–96. http://dx.doi.org/10.63053/ijhes.24.

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Probiotics are live microorganisms that have a positive effect on our health and bring many benefits when consumed in sufficient doses. Maintaining the viability of probiotic bacteria during oral administration can be challenging due to the harsh conditions they face, such as the acidic conditions of the stomach. However, delivery systems for probiotics are very different and important in terms of effectiveness for patient health. These release systems can be categorized into conventional formulations, pharmaceuticals, and non-conventional products, mainly food-based commercial products. In th

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Bustamante, Mariela, B. Dave Oomah, César Burgos-Díaz, Daniela Vergara, Liset Flores, and Carolina Shene. "Viability of Microencapsulated Probiotics in Cross-Linked Alginate Matrices and Chia Seed or Flaxseed Mucilage During Spray-Drying and Storage." Microorganisms 13, no. 7 (2025): 1457. https://doi.org/10.3390/microorganisms13071457.

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Interest in probiotics has not diminished, and techniques to protect them from the environment in which they are found are constantly being innovated. Spray-drying is the most studied and industrially used technique to encapsulate probiotics. Recently, a new process has been developed in which particle formation, alginate cross-linking, and drying are carried out in a single step. In this study, Bifidobacterium infantis, Bifidobacterium longum, Lactobacillus plantarum, and Lactobacillus rhamnosus were microencapsulated by spray-drying using a cross-linked alginate matrix supplemented with chia

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Aswini, T. "Role of Probiotics in Managing Antibiotic-Associated Diarrhea: A Clinical Study." International Journal for Research in Management & Pharmacy 14, no. 4 (2025): 18–24. https://doi.org/10.63345/ijrmp.v14.i4.3.

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Antibiotic-associated diarrhea (AAD) is a common complication during and after antibiotic treatment, disrupting the gut microbiota and leading to significant morbidity. This clinical study examines the role of probiotics in managing AAD, hypothesizing that probiotic supplementation can restore gut flora balance and reduce the incidence and severity of diarrhea. A randomized, placebo-controlled trial was conducted on patients receiving broad-spectrum antibiotics. Participants were divided into two groups: one receiving a specific probiotic formulation and the other a placebo. Data on diarrhea f

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Sali, Sonali S., John D. F. Hale, and Rohit Jain. "A New Frontier in Oral Care: Live Streptococcus salivarius M18 Probiotic Toothpaste." Applied Microbiology 5, no. 1 (2025): 14. https://doi.org/10.3390/applmicrobiol5010014.

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The oral microbiome, a complex ecosystem of microbes, is crucial for oral health. Imbalances in this ecosystem can lead to various oral diseases. Probiotics, live beneficial bacteria, offer a potential solution by strengthening oral defences. This study aimed to develop and evaluate a novel toothpaste containing Streptococcus salivarius M18, a probiotic strain. After ensuring compatibility with toothpaste ingredients, a stable formulation with desirable properties was created. The toothpaste demonstrated cleaning efficacy and antimicrobial activity against oral pathogens in vitro. A clinical t

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Mutmainna, Andi, Handayani Indah Susantia, Suci Ananda, Rismawati Rismawati, and Weny Dwi Ningtyas. "KUALTAS MIKROBIOLOGI DAGING AYAM BROILER DENGAN PEMBERIAN PROBIOTIK EFFECTIVE MICROORGANISME-4 (EM-4) PADA PAKAN." Jurnal Teknologi Pangan dan Gizi 22, no. 1 (2023): 52–59. https://doi.org/10.33508/jtpg.v22i1.4282.

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This study was conducted to determine the effect of probiotic lactic acid bacteria on the Total Plate Count Test in broiler meat. Treatment on broiler was carried out for 35 days with addition of probiotic Effective Microorganisms-4 (EM-4). The treatment group was distributed in four groups of experimental feed formulation. The feed in formulated in P0 not using probiotics, P1 using probiotics of 1 ml/liter of drinking water, P2 using probiotics of 1.5 ml/liter of drinking water and P3 using probiotics of 2 ml/liter of drinking water. Based on the results of the Analysis of Variance (ANOVA) sh

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Nataliіa, Tkachenko, Vikul Svitlana, and Pambuk Svitlana. "MODELING OF PROBIOTIC GEL SHAMPOO RECIPES WITH VEGETABLE EXTRACTS AND MARKETING ANALYSIS OF THEIR MARKET PROMOTION." Technology audit and production reserves 4, no. 3 (48) (2019): 4–11. https://doi.org/10.15587/2312-8372.2019.180423.

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<em>The object of research is the formulation of probiotic gel shampoos enriched with short-chain peptides of whey proteins and probiotic lysate. The intensive growth in demand for new types of cosmetics, including cosmetics with probiotics, causes the desire of manufacturers to constantly improve products to meet consumer requirements. Of the whole complex of factors that form the final quality of natural cosmetics, from the point of view of the consumer, one of the most important is the planning and development of component content of products. Therefore, a promising task is studying the pos

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di Vito, Raffaella, Alessia Di Mezza, Carmela Conte, and Giovanna Traina. "The Crosstalk between Intestinal Epithelial Cells and Mast Cells Is Modulated by the Probiotic Supplementation in Co-Culture Models." International Journal of Molecular Sciences 24, no. 4 (2023): 4157. http://dx.doi.org/10.3390/ijms24044157.

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The intestinal epithelium constitutes a selectively permeable barrier between the internal and external environment that allows the absorption of nutrients, electrolytes, and water, as well as an effective defense against intraluminal bacteria, toxins, and potentially antigenic material. Experimental evidence suggest that intestinal inflammation is critically dependent on an imbalance of homeostasis between the gut microbiota and the mucosal immune system. In this context, mast cells play a crucial role. The intake of specific probiotic strains can prevent the development of gut inflammatory m

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Wójcik, Roman, Joanna Małaczewska, Dawid Tobolski, Jan Miciński, Edyta Kaczorek-Łukowska, and Grzegorz Zwierzchowski. "The Effect of Orally Administered Multi-Strain Probiotic Formulation (Lactobacillus, Bifidobacterium) on the Phagocytic Activity and Oxidative Metabolism of Peripheral Blood Granulocytes and Monocytes in Lambs." International Journal of Molecular Sciences 25, no. 10 (2024): 5068. http://dx.doi.org/10.3390/ijms25105068.

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Probiotic feed additives have attracted considerable research interest in recent years because the effectiveness of probiotics can differ across microbial strains and the supplemented macroorganisms. The present study was conducted on 16 lambs divided equally into two groups (C—control and E—experimental). The examined lambs were aged 11 days at the beginning of the experiment and 40 days at the end of the experiment. The diet of group E lambs was supplemented with a multi-strain probiotic formulation (Lactobacillus plantarum AMT14, Lactobacillus plantarum AMT4, Lactobacillus rhamnosus AMT15,

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K. Sivaranjani, M. Rajesh, L. Subramanian, et al. "Formulation of probiotics from fermented food products: A review." World Journal of Biology Pharmacy and Health Sciences 21, no. 2 (2025): 521–31. https://doi.org/10.30574/wjbphs.2025.21.2.0161.

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Probiotics are living microorganism which may that they provide health benefits when consumed. The most common fermented foods are, yogurt, sauerkraut, soyabean, Honey, Apple cider vinegar etc…, Yogurt: Probiotic fermented milks and yoghurts are acidified and fermented by viable bacteria, usually L. bulgaricus and S. thermophilus, resulting in a thicker product with a longer shelf life. They are a nutrition-dense food, providing a good source of calcium, phosphorus, potassium, vitamin A, vitamin B2, and vitamin B12. Sauerkraut: Probiotic properties of Lactobacillus plantarum. During the fermen

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Sarkar, Surajit. "Postbiotics: Potential as functional ingredients—A review." Food Nutrition Chemistry 2, no. 3 (2024): 241. https://doi.org/10.18686/fnc241.

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A review of the importance of probiotic viability, the functions of viable and postbiotic microorganisms, and their use in nutritious foods has been attempted. Reviews and studies on the effectiveness of dead, inactivated, or destroyed probiotic cells for health benefits have been taken into consideration. Probiotic viability, postbiotics, viable or killed, inactivated probiotic cells, and functional foods were among the keywords used in the data search. Platforms like Google, Pub Med, ResearchGate, and others are used. Probiotics are beneficial to health, but they have certain drawbacks. Furt

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Rodrigues, Pamela Dutra, Isabela de Andrade Arruda Fernandes, Annecler Rech de Marins, Andresa Carla Feihrmann, and Raquel Guttierres Gomes. "Use of Mucilage from Opuntia ficus-indica in the Manufacture of Probiotic Cream Cheese." Processes 12, no. 10 (2024): 2289. http://dx.doi.org/10.3390/pr12102289.

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Cream cheese is a type of fresh cheese with a thin consistency with great potential for adding probiotics. However, artificial thickeners have been used in its production, decreasing consumer satisfaction. This study suggests natural mucilage, specifically from the Cactaceae Opuntia ficus-indica, as a replacement for artificial thickeners due to its thick gelatinous properties. This study evaluated different cream cheese formulations by adding varying concentrations of Opuntia ficus-indica mucilage and the probiotic Lactobacillus acidophilus (L. acidophilus). Four formulations were created: fo

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Sarwar, Abid, Najeeb Ullah, Zhennai Yang, et al. "Assessment of Saccharomyces boulardii CNCM I-745-supplemented probiotic and synbiotic ice cream in mitigating trinitrobenzene sulfonic acid-induced colitis in rats." Italian Journal of Food Science 37, no. 3 (2025): 245–54. https://doi.org/10.15586/ijfs.v37i3.2953.

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Inflammatory bowel disease (IBD) refers to a pair of disorders, namely Crohn’s disease and ulcerative colitis (UC), which are distinguished by persistent gastrointestinal (GI) tract inflammation. Common manifestations include fever and inflammation of the colon, resulting in decreased absorption of nutrition and weight loss. The occur-rence of UC can be decreased by modulating the immune system via gut microflora with probiotics and prebiotics. This study aimed to create a rat model of colitis by utilizing trinitrobenzene sulfonic acid (TNBS) and to correlate intestinal anti-inflammatory activ

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Komar, Devi Nur Na'syifa, and Judiono Judiono. "Boba kefir pineapple beverage innovation: Probiotic and antioxidant refreshment." AcTion: Aceh Nutrition Journal 10, no. 1 (2025): 37. https://doi.org/10.30867/action.v10i1.1888.

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Nutritional intake plays an important role in boosting the immunity. This study aimed to modify the boba drink into a probiotic- and antioxidant-rich drink. Kefir is a source of probiotics. Pineapples, which are rich in vitamin C, have antioxidant properties. The experimental study used a completely randomized design (CRD) with three formulations: F1 (75% kefir: 25% pineapple), F2 (50% kefir: 50% pineapple), and F3 (25% kefir: 75% pineapple). Product manufacturing and organoleptic tests were conducted at the Food Laboratory of Poltekkes Kemenkes Bandung. Laboratory testing was conducted at Sar

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Biagioli, Michele, Adriana Carino, Cristina Di Giorgio, et al. "Discovery of a Novel Multi-Strains Probiotic Formulation with Improved Efficacy toward Intestinal Inflammation." Nutrients 12, no. 7 (2020): 1945. http://dx.doi.org/10.3390/nu12071945.

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Dysbiosis is commonly detected in patients with inflammatory bowel disease (IBD), supporting the concept that a dysregulated immune reaction to bacterial antigens has a pathogenic role in the development of intestinal inflammation. In the present study, we have investigated the beneficial effects of a novel probiotic formulation assembled by combining four probiotics (Streptococcus thermophilus, Lactobacillus casei, Bifidobacterium breve, Bifidobacterium animalis subsp. Lactis) with Bacillus subtilis, a Gram-positive bacterium, with extensive bio-applications. Mice rendered colitic by administ

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Kirtishanti, Aguslina, Heru Wijono, Tjie Kok, et al. "Effect of multi-strain probiotics supplementation on chemotherapy-related side effects among patients with breast cancer: A pilot trial." Pharmacia 72 (March 14, 2025): 1–9. https://doi.org/10.3897/pharmacia.72.e144998.

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This study aimed to identify the effect of a 7-strain probiotics formulation on chemotherapy-related side effects, complete blood counts, blood biochemistry, and Karnofsky performance scores. All patients diagnosed with breast cancer who received chemotherapy at a hospital in Surabaya, Indonesia, were considered eligible to join the study. Before probiotic supplementation, the baseline values of the tested parameters were obtained and later compared with the values after 21–30 days of probiotic supplementation. Multi-strain probiotics supplementation could alleviate the fatigue and nausea symp

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Kirtishanti, Aguslina, Heru Wijono, Tjie Kok, et al. "Effect of multi-strain probiotics supplementation on chemotherapy-related side effects among patients with breast cancer: A pilot trial." Pharmacia 72 (March 14, 2025): 1–9. https://doi.org/10.3897/pharmacia.72.e144998.

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This study aimed to identify the effect of a 7-strain probiotics formulation on chemotherapy-related side effects, complete blood counts, blood biochemistry, and Karnofsky performance scores. All patients diagnosed with breast cancer who received chemotherapy at a hospital in Surabaya, Indonesia, were considered eligible to join the study. Before probiotic supplementation, the baseline values of the tested parameters were obtained and later compared with the values after 21–30 days of probiotic supplementation. Multi-strain probiotics supplementation could alleviate the fatigue and nausea symp

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Al-Hadidi, Ameer, Jason Navarro, Steven D. Goodman, Michael T. Bailey, and Gail E. Besner. "Lactobacillus reuteri in Its Biofilm State Improves Protection from Experimental Necrotizing Enterocolitis." Nutrients 13, no. 3 (2021): 918. http://dx.doi.org/10.3390/nu13030918.

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Necrotizing enterocolitis (NEC) is a devastating disease predominately found in premature infants that is associated with significant morbidity and mortality. Despite decades of research, medical management with broad spectrum antibiotics and bowel rest has remained relatively unchanged, with no significant improvement in patient outcomes. The etiology of NEC is multi-factorial; however, gastrointestinal dysbiosis plays a prominent role in a neonate’s vulnerability to and development of NEC. Probiotics have recently emerged as a new avenue for NEC therapy. However, current delivery methods are

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Bliznjuk, Olga, Igor Ryshchenko, Nataliia Masalitina, Daria Pylypenko, and Yuriy Krasnopolsky. "Analysis of the current status of probiotic drug development." ScienceRise: Pharmaceutical Science, no. 1 (53) (February 28, 2025): 14–25. https://doi.org/10.15587/2519-4852.2025.322767.

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The aim of the work is to analyze the current state of the creation of probiotic preparations. Materials and methods. The work analyzes strains of probiotic bacteria Lactobacillus, Bifidobacterium, Streptococcus, Bacillus, Saccharomyces and other genera. Methods for obtaining probiotics are considered, including the selection of producer strains, the scheme and parameters of culturing producers, collection and concentration, lyophilization, formulation of the product composition, selection of the dosage form. Following technological methods for obtaining dosage forms of probiotics are used: ca

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De Salvo, Carlo, Abdullah Osme, Mahmoud Ghannoum, Fabio Cominelli, and Luca Di Martino. "A New Probiotic Formulation Promotes Resolution of Inflammation in a Crohn’s Disease Mouse Model by Inducing Apoptosis in Mucosal Innate Immune Cells." International Journal of Molecular Sciences 25, no. 22 (2024): 12066. http://dx.doi.org/10.3390/ijms252212066.

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The interaction between gut-residing microorganisms plays a critical role in the pathogenesis of Crohn’s disease (CD), where microbiome dysregulation can alter immune responses, leading to unresolved local inflammation. The aim of this study is to analyze the immunomodulatory properties of a recently developed probiotic + amylase blend in the SAMP1/YitFc (SAMP) mouse model of CD-like ileitis. Four groups of SAMP mice were gavaged for 56 days with the following treatments: 1) probiotic strains + amylase (0.25 mg/100 µL PBS); 2) only probiotics; 3) only amylase; PBS-treated controls. Ilea were c

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Supriya V, Supriya V., Gayathri H. Gayathri H, Jamashin Shajini B. S. Jamashin Shajini B S, Kanmani Pachagoundan Kanmani Pachagoundan, and Nesiga A. Nesiga A. "Formulation of a Probiotic Rich Fermented Product with Catechin Loaded in Bacterium for Nutraceutical Applications." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 78–88. https://doi.org/10.35629/4494-10037888.

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The demand for nutraceutical products has led to an increase in popularity for formulations rich in probiotics aimed at enhancing human health. This study's primary goal is to develop a new fermented food fortified with probiotic bacteria containing catechins, which are intended to offer enhanced nutraceutical benefits. By incorporating catechins—flavonoids known for their antibacterial, anti-inflammatory, and antioxidant properties—into the probiotic matrix, the product’s shelf life and health benefits are enhanced. The project's aim is to identify and isolate a robust probiotic strain capabl

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di Vito, Raffaella, Carmela Conte, and Giovanna Traina. "A Multi-Strain Probiotic Formulation Improves Intestinal Barrier Function by the Modulation of Tight and Adherent Junction Proteins." Cells 11, no. 16 (2022): 2617. http://dx.doi.org/10.3390/cells11162617.

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In healthy individuals, tight junction proteins (TJPs) maintain the integrity of the intestinal barrier. Dysbiosis and increased intestinal permeability are observed in several diseases, such as inflammatory bowel disease. Many studies highlight the role of probiotics in preventing intestinal barrier dysfunction. The present study aims to investigate the effects of a commercially available probiotic formulation of L. rhamnosus LR 32, B. lactis BL 04, and B. longum BB 536 (Serobioma, Bromatech s.r.l., Milan, Italy) on TJPs and the integrity of the intestinal epithelial barrier, and the ability

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Tremblay, Annie, Xiaoyu Xu, James Colee, and Thomas A. Tompkins. "Efficacy of a Multi-Strain Probiotic Formulation in Pediatric Populations: A Comprehensive Review of Clinical Studies." Nutrients 13, no. 6 (2021): 1908. http://dx.doi.org/10.3390/nu13061908.

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A probiotic formulation combining Lactobacillus helveticus Rosell®-52, Bifidobacterium infantis Rosell®-33, and Bifidobacterium bifidum Rosell®-71 with fructooligosaccharides, first commercialized in China, has been sold in over 28 countries since 2002. Clinical studies with this blend of strains were conducted mainly in pediatric populations, and most were published in non-English journals. This comprehensive review summarizes the clinical studies in infants and children to evaluate the efficacy of this probiotic for pediatric indications. Literature searches for pediatric studies on Biostime

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Tamašauskaitė, Laura, Vidmantė Minelgaitė, Aušra Šipailienė, Rimantė Vinauskienė, Viktorija Eisinaitė, and Daiva Leskauskaitė. "Bigel Matrix Loaded with Probiotic Bacteria and Prebiotic Dietary Fibers from Berry Pomace Suitable for the Development of Probiotic Butter Spread Product." Gels 10, no. 5 (2024): 349. http://dx.doi.org/10.3390/gels10050349.

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This study presents a novel approach to developing a probiotic butter spread product. We evaluated the prebiotic activity of soluble dietary fibers extracted from cranberry and sea buckthorn berry pomace with different probiotic strains (Limosilactobacillus reuteri, Lacticaseibacillus paracasei, and Lactiplantibacillus plantarum), uploaded selected compatible combination in the bigel matrix, and applied it in the probiotic butter spread formulation. Bigels and products were characterized by physical stability, rheological, textural properties, and viability of probiotics during storage at diff

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Gruber, Christina, Dan Bui-Chau-Truc, Jutta C. Kesselring, Ngoc Diem Nguyen, Benedict Standen, and Silvia Wein. "Diet-Independent Positive Effects of a Multi-Species Probiotic on the Growth Performance and Resistance against Vibrio parahaemolyticus in White Leg Shrimp." Animals 13, no. 3 (2023): 331. http://dx.doi.org/10.3390/ani13030331.

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Probiotic feed additives can support the gut health of shrimp and thereby improve performance, production efficiency and disease resistance. Two experiments in white leg shrimp aimed to investigate the effects of a multi-species probiotic feed supplement (AquaStar®, 3 g/kg feed, Biomin GmbH, Getzersdorf, Austria) in feed formulations with different marine meal levels (32% and 15%) on growth performance and resistance against Vibrio parahaemolyticus. Juvenile shrimp were stocked in a recirculating aquaculture tank system at a density of 20 shrimp/46.8 L and were fed diets with and without the p

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Herkenhoff, Marcos Edgar, Igor Ucella Dantas de Medeiros, Luiz Henrique Grotto Garutti, Mateus Kawata Salgaço, Katia Sivieri, and Susana Marta Isay Saad. "Cashew By-Product as a Functional Substrate for the Development of Probiotic Fermented Milk." Foods 12, no. 18 (2023): 3383. http://dx.doi.org/10.3390/foods12183383.

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Cashew (Anacardium occidentale) processing generates a by-product (CB) with potential for health benefits and that could be a favorable ingredient to be added to a probiotic food matrix. This study aimed to assess the functional attributes of CB in fermented milk with a probiotic and a starter culture using in vitro gastrointestinal conditions. Two formulations were tested, without CB (Control Formulation—CF) and with CB (Test Formulation—TF), and the two strains most adapted to CB, the probiotic Lacticaseibacillus paracasei subsp. paracasei F19® and the starter Streptococcus thermophilus ST-M

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Tonde, A. B., and A. A. Bhoite. "A REVIEW ON FRUIT JUICE PROBIOTIFICATION MAJOR CHALLENGES AND TECHNOLOGICAL CONSTRAINTS." International Journal of Applied and Advanced Scientific Research (IJAASR) 5, no. 1 (2020): 6–11. https://doi.org/10.5281/zenodo.3634332.

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Fruit juices are now integral part of dietary regime and are widely accepted by consumer as part of daily healthy diet plan. In light of the research based on the food fortification the juices are mainly studied for the formulation of probiotic juices. Many juices till date have proven as good source for the delivery of probiotic in human intestine. More research still needs to encourage for development of quality probiotic juices from variety of fruits. The technological   constrains needs to resolve for better commercialization. To gain the wide acceptability of probiotic juices th

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Patil, Abhinandan, Firoj Tamboli, Dinanath Gaikwad, Pralhad Mudalkar, and Kamal Alaskar. "Formulation and Evaluation of Probiotics Properties of Lactobacillus with Antimicrobial Activities." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 02 (2022): 522–28. http://dx.doi.org/10.25258/ijddt.13.2.11.

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This study emphasizes exhibiting probiotics activities of Lactobacillus, formulation as granules, synthesizing nanoparticle by using Lactobacillus and demonstrating antimicrobial activity. Probiotics are not only microbes present in milk but also as are functional food to heal diseases. Four different isolates were obtained from sheep milk. These microbe’s growth profile was observed in different animal milk, and some biochemical studies were conducted. All four isolates were tested against gram positive and negative microorganisms like Salmonella typhi, Escherichia coli, Proteus vulgaris, Ent

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Sandionigi, Anna, Alessandra De Giani, Francesco Tursi, et al. "Effectiveness of Multistrain Probiotic Formulation on Common Infectious Disease Symptoms and Gut Microbiota Modulation in Flu-Vaccinated Healthy Elderly Subjects." BioMed Research International 2022 (January 27, 2022): 1–16. http://dx.doi.org/10.1155/2022/3860896.

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The decline of the immune system with aging leads elderly people to be more susceptible to infections, posing high risk for their health. Vaccination is thus important to cope with this risk, even though not always effective. As a strategy to improve protection, adjuvants are used in concomitance with vaccines, however, occasionally producing important side effects. The use of probiotics has been proposed as an alternative to adjuvants due to their efficacy in reducing the risk of common infections through the interactions with the immune system and the gut microbiota. A placebo-controlled, ra

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Moonsamy, Ghaneshree, Yrielle Roets-Dlamini, Cebeni Nkosihawukile Langa, and Santosh Omrajah Ramchuran. "Advances in Yeast Probiotic Production and Formulation for Preventative Health." Microorganisms 12, no. 11 (2024): 2233. http://dx.doi.org/10.3390/microorganisms12112233.

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The use of probiotics has been gaining popularity in terms of inclusion into human diets over recent years. Based on properties exerted by these organisms, several benefits have been elucidated and conferred to the host. Bacteria have been more commonly used in probiotic preparations compared to yeast candidates; however, yeast exhibit several beneficial properties, such as the prevention and treatment of diarrhea, the production of antimicrobial agents, the prevention of pathogen adherence to intestinal sites, the maintenance of microbial balance, the modulation of the immune system, antibiot

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Gargari, Giorgio, Valentina Taverniti, Ranjan Koirala, Claudio Gardana, and Simone Guglielmetti. "Impact of a Multistrain Probiotic Formulation with High Bifidobacterial Content on the Fecal Bacterial Community and Short-Chain Fatty Acid Levels of Healthy Adults." Microorganisms 8, no. 4 (2020): 492. http://dx.doi.org/10.3390/microorganisms8040492.

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The consumption of probiotic products is continually increasing, supported by growing scientific evidence of their efficacy. Considering that probiotics may primarily affect health (either positively or negatively) through gut microbiota modulation, the first aspect that should be evaluated is their impact on the intestinal microbial ecosystem. In this study, we longitudinally analyzed the bacterial taxonomic composition and organic acid levels in four fecal samples collected over the course of four weeks from 19 healthy adults who ingested one capsule a day for two weeks of a formulation cont

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Supriya, Yadav* Dr. S. V. Raut. "Development of a Probiotic-Based Health Supplement: Screening, Characterization, and Stability Assessment." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 2658–77. https://doi.org/10.5281/zenodo.15096989.

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Probiotic-based health supplements have gained considerable attention due to their potential benefits in improving gut health, immunity, and overall well-being. This study focuses on the screening, characterization, and formulation of a probiotic health supplement, emphasizing stability assessment to ensure long-term efficacy. Lactic acid bacteria (LAB) were isolated from dairy samples collected from various sources and characterized using biochemical and molecular techniques. Their ability to survive under different pH conditions, bile salt concentrations, NaCl levels, and cholesterol assimil

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