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Journal articles on the topic 'Problematic severe asthma'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Pike, Katharine C., Mark L. Levy, John Moreiras, and Louise Fleming. "Managing problematic severe asthma: beyond the guidelines." Archives of Disease in Childhood 103, no. 4 (2017): 392–97. http://dx.doi.org/10.1136/archdischild-2016-311368.

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This review discusses issues related to managing problematic severe asthma in children and young people. A small minority of children have genuinely severe asthma symptoms which are difficult to control. Children with genuinely severe asthma need investigations and treatments beyond those described within conventional guidelines. However, the majority of children with poor symptom control despite high-intensity treatment achieve improvement in their asthma control once attention has been paid to the basics of asthma management. Basic asthma management requires optimisation of inhaler technique

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2

Scotney, Elizabeth, and Sejal Saglani. "Diagnosis and Management of Problematic Severe Asthma." Acta Medica Academica 49, no. 2 (2020): 117. http://dx.doi.org/10.5644/ama2006-124.291.

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<p>This review will outline an evidence-based approach for diagnosing and managing children with problematic severe asthma (PSA). Children with PSA have uncontrolled asthma symptoms, despite maximal prescribed asthma treatment. These children have high morbidity and mortality and should be referred for specialist respiratory assessment and management. The first step in the assessment of a child with PSA is confirming the diagnosis of asthma using objective evidence. Following this, an assess- ment of inhaled corticosteroid adherence and a multi-disciplinary team approach is essential for

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3

Mandal, A., and PK Shahi. "Is it difficult to treat asthma in children." Journal of Medical Research and Innovation 1, no. 3 (2017): 23–30. https://doi.org/10.5281/zenodo.825267.

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Asthma, the commonest chronic lung disease in childhood, is managed effectively with inhaled medications in most of the cases. But a subset of pediatric asthma patients continues to experience substantial morbidity even after higher doses of medications; they are referred to as problematic severe asthma. In many such cases, the apparent resistance to therapy is actually due to a number of remediable factors. These cases are called ‘difficult to treat asthma’. The physician dealing with a child with problematic severe asthma needs to follow a systematic step- wise approach to find any possible

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4

Lodrup Carlsen, K. C., G. Hedlin, A. Bush, et al. "Assessment of problematic severe asthma in children." European Respiratory Journal 37, no. 2 (2010): 432–40. http://dx.doi.org/10.1183/09031936.00091410.

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5

Nagakumar, Prasad, and Huw Thomas. "Management of problematic severe asthma in children." Paediatrics and Child Health 27, no. 7 (2017): 318–23. http://dx.doi.org/10.1016/j.paed.2017.03.002.

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6

Mandal, Anirban, and Puneet Kaur Sahi. "Is it Difficult to Treat Asthma in Children?" Journal of Medical Research and Innovation 1, no. 3 (2017): 23–30. http://dx.doi.org/10.15419/jmri.77.

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Asthma, the commonest chronic lung disease in childhood, is managed effectively with inhaled medications in most of the cases. But a subset of pediatric asthma patients continues to experience substantial morbidity even after higher doses of medications; they are referred to as problematic severe asthma. In many such cases, the apparent resistance to therapy is actually due to a number of remediable factors. These cases are called ‘difficult to treat asthma’. The physician dealing with a child with problematic severe asthma needs to follow a systematic step- wise approach to find any possible

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7

BUSH, Andrew. "Problematic, severe asthma in children: a new concept and how to manage it." Acta medica Lituanica 17, no. 1-2 (2010): 51–64. http://dx.doi.org/10.15388/amed.2010.21692.

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Most children with asthma respond to low doses of inhaled corticosteroids, but a few remain symptomatic despite being prescribed the routine usual asthma medications. The first steps are to ensure that the diagnosis is correct and that the inhaled medications are being given regularly with an appropriately used device. If the children continue to be symptomatic, with any or all of chronic symptoms, acute exacerbations, the need for regular oral corticosteroids, or persistent airflow limitation, then they are considered to have problematic, severe asthma. The next step is to perform a detailed

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8

Gambhir, N., J. Longman, P. Nagakumar, et al. "G522(P) The role of inpatient assessment of problematic severe asthma." Archives of Disease in Childhood 101, Suppl 1 (2016): A308—A309. http://dx.doi.org/10.1136/archdischild-2016-310863.509.

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9

Verkleij, Marieke, Anita Beelen, Bart E. van Ewijk, and Rinie Geenen. "Multidisciplinary treatment in children with problematic severe asthma: A prospective evaluation." Pediatric Pulmonology 52, no. 5 (2016): 588–97. http://dx.doi.org/10.1002/ppul.23623.

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10

Stewart, Amy C., Kenneth N. Gannon, Fran Beresford, and Louise Fleming. "Adolescent and caregivers’ experiences of electronic adherence assessment in paediatric problematic severe asthma." Journal of Child Health Care 22, no. 2 (2018): 238–50. http://dx.doi.org/10.1177/1367493517753082.

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This study explored the experiences of adolescents and their caregivers regarding adherence to inhaled corticosteroids which are assessed through an electronic monitoring device (EMD). These devices are increasingly being used for assessing medication adherence, yet there is little information about patient’s experience of these tools. Semi-structured interviews were conducted with eight adolescents with severe asthma, aged 11–15 years, who were electronically monitored as part of their care, along with their caregivers. Interviews were analysed using thematic analysis. Three themes were ident

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11

Sharples, James, Atul Gupta, Louise Fleming, et al. "Long-term effectiveness of a staged assessment for paediatric problematic severe asthma." European Respiratory Journal 40, no. 1 (2012): 264–67. http://dx.doi.org/10.1183/09031936.00209511.

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12

Lang, AM, J. Konradsen, K.-H. Carlsen, et al. "Identifying problematic severe asthma in the individual child - does lung function matter?" Acta Paediatrica 99, no. 3 (2010): 404–10. http://dx.doi.org/10.1111/j.1651-2227.2009.01625.x.

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13

Sharples, J., A. Gupta, L. Fleming, et al. "P76 Long-term effectiveness of a staged assessment for problematic severe asthma." Thorax 66, Suppl 4 (2011): A99. http://dx.doi.org/10.1136/thoraxjnl-2011-201054c.76.

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14

Bush, Andrew. "Problematic, severe asthma in children: a new concept and how to manage it." Acta medica Lituanica 17, no. 1 (2010): 51–64. http://dx.doi.org/10.2478/v10140-010-0007-7.

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15

Hedlin, G., A. Bush, K. Lodrup Carlsen, et al. "Problematic severe asthma in children, not one problem but many: a GA2LEN initiative." European Respiratory Journal 36, no. 1 (2010): 196–201. http://dx.doi.org/10.1183/09031936.00104809.

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16

Nagakumar, Prasad, Nikki Gambir, Nina Sanghani, et al. "Role of a prolonged inpatient admission when evaluating children with problematic severe asthma." European Respiratory Journal 51, no. 2 (2018): 1701061. http://dx.doi.org/10.1183/13993003.01061-2017.

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17

Yii, A. C. A., J. H. Y. Tan, T. S. Lapperre, et al. "Long-term future risk of severe exacerbations: Distinct 5-year trajectories of problematic asthma." Allergy 72, no. 9 (2017): 1398–405. http://dx.doi.org/10.1111/all.13159.

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18

Abdulhamid, A.K. "CHILDHOOD ASTHMA. DIAGNOSTIC AND THERAPEUTIC PROBLEMS. GINA 2024 RECOMMENDATIONS." Znanstvena misel journal, no. 99 (February 24, 2025): 37–46. https://doi.org/10.5281/zenodo.14919708.

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Childhood asthma is the most common chronic disease in childhood (12-14%) worldwide and 3-10% of asthmatics suffer from severe asthma. Despite the enormous progress in the diagnosis and treatment of childhood asthma, there are still some challenges in terms of diagnosis, as well as in the selection of adequate and timely maintenance treatment, which remain problematic. Overdiagnosis leads to unnecessary drug therapy and associated side effects, and on the other hand, underdiagnosis carries the risk of daily symptoms, potentially serious exacerbations and long-term remodeling of the airways and

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19

Audi, Nadia, James Cook, Becky Tomlin, et al. "An audit of the impact of Covid-19 pandemic on the emotional wellbeing of children and parents with problematic severe asthma." Sushruta Journal of Health Policy & Opinion 14, no. 2 (2021): 1–19. http://dx.doi.org/10.38192/14.2.3.

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COVID-19 pandemic and the associated redeployment of healthcare infrastructure had a significant impact on normal services. Amongst a cohort with severe asthma children and young persons, attending a regional service, this questionnaire explored the impact of the pandemic and associated lockdown on emotional well-being.  Our findings suggest that there were significant anxieties associated with the ability to access primary and secondary care services, medication during the pandemic – lockdown, as well as the psychological impact of social distancing and missing school work for this coho

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20

van de Griendt, Erik-Jonas, Marieke Verkleij, J. Menno Douwes, Wim M. C. van Aalderen, and Rinie Geenen. "Problematic severe asthma in children treated at high altitude: tapering the dose while improving control." Journal of Asthma 51, no. 3 (2014): 315–19. http://dx.doi.org/10.3109/02770903.2013.871557.

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21

Konradsen, Jon R., Björn Nordlund, Marika Lidegran, et al. "Problematic severe asthma: A proposed approach to identifying children who are severely resistant to therapy." Pediatric Allergy and Immunology 22, no. 1-Part-I (2010): 9–18. http://dx.doi.org/10.1111/j.1399-3038.2010.01098.x.

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22

Verkleij, Marieke, Erik-Jonas van de Griendt, Vivian Colland, Nancy van Loey, Anita Beelen, and Rinie Geenen. "Parenting Stress Related to Behavioral Problems and Disease Severity in Children with Problematic Severe Asthma." Journal of Clinical Psychology in Medical Settings 22, no. 2-3 (2015): 179–93. http://dx.doi.org/10.1007/s10880-015-9423-x.

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23

T. Ricci, Cristiane de Abreu, Laura Maria de Lima B. F. Lasmar, Paulo M. Pitrez, Raimundo F. Mascarenhas, and Paulo A. M. Camargos. "Sputum Induction in Children and Adolescents with Problematic Severe Asthma: Success Rate, Safety and Tolerability." Open Allergy Journal 8, no. 1 (2015): 7–13. http://dx.doi.org/10.2174/1874838401508010007.

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Background: In problematic severe asthma (PSA), inflammatory phenotypes can by identified by assessing cellularity in induced sputum (IS) samples. However, there have been few studies employing sputum induction (SI) in pediatric patients. Objectives: To assess the success rate, safety and tolerability of SI, as well as IS sample cellularity, in pediatric PSA patients. Methods: We conducted a cross-sectional study involving 44 pediatric PSA patients. We collected IS samples using inhalations of nebulized saline solution. On the basis of the post-bronchodilator forced expiratory volume in one se

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24

Morishima, Yuko, Satoshi Ano, Yukio Ishii, et al. "Th17-Associated Cytokines as a Therapeutic Target for Steroid-Insensitive Asthma." Clinical and Developmental Immunology 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/609395.

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Steroid-insensitive asthma is an infrequent but problematic airway disease that presents with persistent symptoms, airflow limitation, or recurrent exacerbations even when treated with steroid-based therapies. Because of unsatisfactory results obtained from currently available therapies for steroid-insensitive asthma, a better understanding of its pathogenesis and the development of new targeted molecular therapies are warranted. Recent studies indicated that levels of interleukin (IL)-17 are increased and both eosinophils and neutrophils infiltrate the airways of severe asthmatics. IL-17 is a

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25

Nordlund, B., JR Konradsen, C. Pedroletti, I. Kull, and G. Hedlin. "The clinical benefit of evaluating health-related quality-of-life in children with problematic severe asthma." Acta Paediatrica 100, no. 11 (2011): 1454–60. http://dx.doi.org/10.1111/j.1651-2227.2011.02359.x.

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26

Glushkova, Evgeniya F., and Tatiana N. Surovenko. "Is it always easy for children with mild asthma?" Meditsinskiy sovet = Medical Council, no. 1 (March 21, 2021): 203–12. http://dx.doi.org/10.21518/2079-701x-2021-1-203-212.

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Bronchial asthma is the most common chronic disease of children, the worst way is their quality of life. Compliance in the treatment of children is very important, since the actual effect of a drug is determined by both the effective drugs and patient adherence and correct use. A relevant test is the use of mild asthma, which is able to control bronchial hyperreactivity associated with exercise, cold air, and other nonspecific irritants (smoke, odors, etc.). Planning of baseline therapy for children with mild asthma aged 5 years old and younger is particularly problematic for paediatricians du

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27

Kam, Karen, Alberto Nettel-Aguirre, Ian Mitchell, David W. Johnson, and Gillian Currie. "A multidisciplinary clinic for pediatric patients with problematic severe asthma: Impact on clinical outcomes and healthcare utilization." Canadian Journal of Respiratory, Critical Care, and Sleep Medicine 3, no. 3 (2019): 128–33. http://dx.doi.org/10.1080/24745332.2018.1542640.

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28

Nagakumar, P., P. Hall, M. Bracken, S. Saglani, A. Bush, and L. Fleming. "P55 Is Prescription Uptake And Medication Adherence Rating Scale (mars) A Useful Tool In Assessing Asthma Control In Children With Problematic Severe Asthma (psa)?" Thorax 69, Suppl 2 (2014): A98. http://dx.doi.org/10.1136/thoraxjnl-2014-206260.196.

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29

Kwizera, Richard, Felix Bongomin, Ronald Olum, et al. "Evaluation of an Aspergillus IgG/IgM lateral flow assay for serodiagnosis of fungal asthma in Uganda." PLOS ONE 16, no. 5 (2021): e0252553. http://dx.doi.org/10.1371/journal.pone.0252553.

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Background Diagnosis of fungal allergies in asthma remains problematic in low-and middle-income countries due to non-availability of point-of-care testing. In this study, we aimed to evaluate the performance of an Aspergillus immunochromatographic technology (ICT) IgG/M lateral flow device (LFD) for the serological diagnosis of allergic bronchopulmonary aspergillosis (ABPA) and severe asthma with fungal sensitisation (SAFS) among Ugandan adult asthmatics. Methods 374 adult (aged ≥18years) asthmatics in the African Severe Asthma Program study, Ugandan site constituted the study population. ABPA

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Kobashi, Misato, Hiroyo Yoshimoto, Hanako Ohke, et al. "Multiple Abnormal Cutaneous Findings in a Patient With Hypomelanosis of Ito Undergoing General Anesthesia." Anesthesia Progress 71, no. 4 (2024): 188–93. https://doi.org/10.2344/23-0025.

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Hypomelanosis of Ito (HI), a neurocutaneous syndrome, is characterized by skin depigmentation and skeletal, muscular, central nervous system, cardiac, and renal manifestations. A wide variety of cutaneous manifestations besides depigmentation have been reported. Herein we describe a 23-year-old woman with HI whose extracutaneous symptoms included severe mental and motor impairment, convulsions, and deformity of the orofacial region. She also had severe obesity, asthma, multiple allergies, and skin hypersensitivity. Although no extracutaneous manifestations were problematic during perioperative

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Sulaimanov, Sh A. "Allergic diseases in children in the age of the COVID-19 pandemic." Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 67, no. 6 (2023): 25–32. http://dx.doi.org/10.21508/1027-4065-2022-67-6-25-32.

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COVID-19 coronavirus infection caused by the SARS-CoV-2 virus has become a real disaster for all of humanity. Today, issues related to diagnostics, clinical presentations, treatment of the complications, preventive measures, including vaccination for a new coronavirus infection, are relevant. It is also important to identify risk factors for a severe course of the disease, features of the development of infection against the background of comorbid conditions and different immunological reactivity of the human body. The comorbidity of allergic and infectious diseases is based on the common humo

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Kaur, Manminder, Thomas Bell, Samira Salek-Ardakani, and Tracy Hussell. "Macrophage adaptation in airway inflammatory resolution." European Respiratory Review 24, no. 137 (2015): 510–15. http://dx.doi.org/10.1183/16000617.0030-2015.

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Bacterial and viral infections (exacerbations) are particularly problematic in those with underlying respiratory disease, including post-viral infection, asthma, chronic obstructive pulmonary disease and pulmonary fibrosis. Patients experiencing exacerbations tend to be at the more severe end of the disease spectrum and are often difficult to treat. Most of the unmet medical need remains in this patient group. Airway macrophages are one of the first cell populations to encounter airborne pathogens and, in health, exist in a state of reduced responsiveness due to interactions with the respirato

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Bandeira, Teresa, Filipa Negreiro, Rosário Ferreira, et al. "Clinical, radiological, and physiological differences between obliterative bronchiolitis and problematic severe asthma in adolescents and young adults: The early origins of the overlap syndrome?" Pediatric Pulmonology 46, no. 6 (2011): 573–80. http://dx.doi.org/10.1002/ppul.21405.

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34

Jungewelter, Soile. "O-179 GLUTEN-FREE TREND CAUSES OCCUPATIONAL RHINITIS, ASTHMA AND DERMATITIS AMONG BAKERS DUE TO MORE UNUSUAL EXPOSURE – HOW TO TACKLE THIS EMERGING PROBLEM?" Occupational Medicine 74, Supplement_1 (2024): 0. http://dx.doi.org/10.1093/occmed/kqae023.0901.

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Abstract Introduction Baker’s rhinitis and asthma caused by inhaled cereal flours are among the most common and well-known occupational diseases. Lately, gluten-free or vegan diets have increased in popularity and bakers’ allergens are changing in parallel. Methods We created an information sheet for the workplaces with practical advice on preventive measures. Results Systemic preventive measures may include easy-to-clean surfaces and sufficient cleaning of workplaces to minimize exposure to dust. Technical measures might include use of local- or area-based exhaust ventilation and dust removal

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Kumar, Riten, Shahina Qureshi, Prita Mohanty, Sreedhar P. Rao, and Scott T. Miller. "A Short Course of Prednisone in the Management of Acute Chest Syndrome of Sickle Cell Disease." Blood 112, no. 11 (2008): 1417. http://dx.doi.org/10.1182/blood.v112.11.1417.1417.

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Abstract Background: Acute chest syndrome is defined as the presence of acute pulmonary findings in an individual with sickle cell disease. A brief course of dexamethasone was shown to significantly attenuate the course of mild to moderate ACS, but treated patients appeared to have an increased risk of readmission, generally for pain episodes, as compared to controls (31.5% vs. 4.7%; p=0.09). In a more recent retrospective review of patients with ACS, the readmission rate was even more alarming, with 59% of patients who received steroids alone (without transfusion) readmitted, again primarily

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Hussain, Mubashir, and Imam Ali Shah. "Symptoms of panic disorder may lead to a potential misdiagnosis as a cardiopulmonary disease, particularly in rural areas." Journal of the Pakistan Medical Association 74, no. 12 (2024): 2219. http://dx.doi.org/10.47391/jpma.21108.

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Madam, The hallmark of panic disorder is erratic, recurrent, sudden bouts of severe anxiety referred to as "panic attacks," which render patients fearful of having another episode. These episodes are accompanied by symptoms such as palpitations, shortness of breath, chest tightness, dizziness, choking, fainting, sweating, and neurological symptoms. A study in 2022 suggests that the prevalence of panic attacks is 13.2%, mostly among women, the unemployed, and low-income individuals. The high rate of misdiagnosis (85.6%) is an issue that needs to be addressed.1 Panic symptoms can resemble severa

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37

Irfan, Umair, Aneeza Irfan, Adnan Latif Malik, Muhammad Iqbal, and Irfan Mehboob. "VITAMIN D INSUFFICIENCY IN FOUR MAJOR HOSPITALS OF PUNJAB." Pakistan Postgraduate Medical Journal 29, no. 4 (2020): 142–44. http://dx.doi.org/10.51642/ppmj.v29i4.39.

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Objective: To demonstrate vitamin D deficiency in the general population of Punjab Study Design: Observational, Cross-Sectional Place and Duration: Multicentre study conducted at different Public Centre Teaching hospitals of Punjab – i.e. SIMS, SZH, PGMI/LGH, and FJMC Methodology: The general population visiting hospitals that compromised of patients and visitors, as well as the local hospital staff that consisted of medical and paramedical staff, were given the opportunity to take part in the study. Results: A total of 1075 samples were collected from the patients, vis

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Scotney, Elizabeth, Saskia Burchett, Thomas Goddard, and Sejal Saglani. "Pediatric problematic severe asthma: Recent advances in management." Pediatric Allergy and Immunology, June 3, 2021. http://dx.doi.org/10.1111/pai.13543.

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39

De Benedictis, F. M., I. Carloni, and A. Bush. "The dark side of the moon: severe therapy-resistant asthma in children." Monaldi Archives for Chest Disease 77, no. 2 (2015). http://dx.doi.org/10.4081/monaldi.2012.156.

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Problematic severe asthma is the term used to describe children whose asthma is not responsive to standard therapy with high-dose inhaled corticosteroids and additional controllers. These children need to be assessed by a step-wise systematic protocol in order to confirm the diagnosis, evaluate co-morbidities, assess the adherence to treatment, and finally evaluate the basic management. More than half of these children have “difficult-to-treat asthma”, which improves if the basic management is correct. Children whose asthma remains uncontrolled despite resolution of any reversible factors are

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Meme, Hellen, Evans Amukoye, Cressida Bowyer, et al. "Asthma symptoms, spirometry and air pollution exposure in schoolchildren in an informal settlement and an affluent area of Nairobi, Kenya." Thorax, June 6, 2023, thorax—2023–220057. http://dx.doi.org/10.1136/thorax-2023-220057.

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BackgroundAlthough 1 billion people live in informal (slum) settlements, the consequences for respiratory health of living in these settlements remain largely unknown. This study investigated whether children living in an informal settlement in Nairobi, Kenya are at increased risk of asthma symptoms.MethodsChildren attending schools in Mukuru (an informal settlement in Nairobi) and a more affluent area (Buruburu) were compared. Questionnaires quantified respiratory symptoms and environmental exposures; spirometry was performed; personal exposure to particulate matter (PM2.5) was estimated.Resu

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MB, Marina, Ramli R, and Primuharsa Putra SHA. "Severe Oro-laryngeal Thrush Following Excessive Use of Steroid Inhaler." IIUM Medical Journal Malaysia 9, no. 1 (2020). http://dx.doi.org/10.31436/imjm.v9i1.1429.

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Introduction: Inhaled steroids such as fluticasone propionate and beclomethasone dipropionate play an important role in the treatment of bronchial asthma. Its usage facilitates disease control in asthmatic patients, resulting in improved quality of life. Because of its benefit, the inhaled steroid is used extensively, at higher doses and for longer duration. However, the localized effects of inhaled corticosteroids on oral/laryngeal mucosa, such as fungal infections can be problematic. Case Report: We report a case of oropharyngeal and laryngeal candidiasis following a long period and high dos

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Cappuccio, Antonietta, Silvia Napolitano, Francesco Menzella, et al. "Use of narrative medicine to identify key factors for effective doctor–patient relationships in severe asthma." Multidisciplinary Respiratory Medicine 14 (September 2, 2019). http://dx.doi.org/10.4081/mrm.2019.27.

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Background: In this project the authors use a narrative medicine (NM) approach to assess the promotion of trust in the relationship between physicians and their asthma patients. Methods: Following a NM educational course for physicians, a research was carried out in which at least 5 written narratives (parallel charts) for each participating physician were collected and qualitatively analysed according to Bury’s classification and the Grounded Theory. Results: The results of this study were of speculative and clinical interest. In particular, 66 participants wrote 314 narratives (246 on adult

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Ferrante, Giuliana, Velia Malizia, Roberta Antona, Giovanni Corsello, and Stefania La Grutta. "The value of FeNO measurement in childhood asthma: uncertainties and perspectives." Multidisciplinary Respiratory Medicine 8 (July 31, 2013). http://dx.doi.org/10.4081/mrm.2013.549.

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Asthma is considered an heterogeneous disease, requiring multiple biomarkers for diagnosis and management. Fractional exhaled nitric oxide in exhaled breath (FeNO) was the first useful non-invasive marker of airway inflammation in asthma and still is the most widely used. The non-invasive nature and the relatively easy use of FeNO technique make it an interesting tool to monitor airway inflammation and rationalize corticosteroid therapy in asthmatic patients, together with the traditional clinical tools (history, physical examination and lung function tests), even if some controversies have be

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Humane, Shubhangi, Dipti Rana, and Shilpa Sarang Kore. "Anaesthetic Management of a Centrally Located Bronchial Carcinoid Tumour: Challenges in Airway Management and Perioperative Care." JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, July 1, 2025. https://doi.org/10.7860/jcdr/2025/78835.21155.

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Bronchial Carcinoid Tumours (BCT) is a rare form of neuroendocrine tumours with severe anaesthetic challenges since they are centrally positioned in the bronchial tree, which can make them highly problematic in airway management. Even though they are commonly indolent, sometimes they may obstruct the airway, cause bleeding, or occasionally precipitate a carcinoid crisis. Hence, proper preoperative preparation is essential. We present a case report on the anaesthetic management of a 58-year-old female admitted for the removal of a BCT by wedge resection complicated by bronchial asthma. She had

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Rojas-Fermin, Rita A., Anel E. Guzman-Marte, Ann S. Sanchez-Marmolejos, Francisco Guzman-Ricardo, Yeison Reyes, and Ruben Calcano. "P-720. Are we aware of the RSV problematic in the Dominican Republic?" Open Forum Infectious Diseases 12, Supplement_1 (2025). https://doi.org/10.1093/ofid/ofae631.916.

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Abstract Background Respiratory Syncytial Virus (RSV) is a common cause of respiratory illness that could have a severe presentation in infants and elderly patients. As in other LATAM countries, RSV diagnosis is limited due to a lack of testing or access, and there is scarce data on the epidemiology, clinical impact, and mortality. Our aim was to characterize the disease in patients admitted to a hospital setting. Distribution of admitted patients by age Source: Statistical registry of the authors Methods We performed a retrospective review of admitted patients in a tertiary 289-bed hospital w

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Kenner, Alison. "The Healthy Asthmatic." M/C Journal 16, no. 6 (2013). http://dx.doi.org/10.5204/mcj.745.

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Tiffany is running down a suburban street with headphones and a hoodie on. Her breath is clearly audible, rhythmic, steady, and in pace with her footsteps. The Tiffany’s Story video testimonial on the Be Smart. Be Well. website then cuts to Tiffany sitting at home describing her earlier experiences with asthma: “The hospital became like my second home... I couldn’t breathe on my own.” Dr. Wolf, who has been treating Tiffany since she was diagnosed with asthma at age 8, joins in, “At that time she had really severe asthma. It was very difficult to manage and remained very difficult to manage fo

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