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Dissertations / Theses on the topic 'Process Analytical Technology'

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Published: 4 June 2021
Last updated: 26 July 2025

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1

Cosby, Samuel T. (Samuel Thomas). "Process Analytical Technology in biopharmaceutical manufacturing." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/80911.

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Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering; in conjunction with the Leaders for Global Operations Program at MIT, 2013.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (p. 83-85).<br>Process Analytical Technology (PAT) became a well-defined concept within the pharmaceutical in
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2

STRANI, LORENZO. "PROCESS ANALYTICAL TECHNOLOGY APPROACHES FOR DAIRY INDUSTRY." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/814055.

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Questo lavoro di tesi risponde al bisogno dell’industria lattiero-casearia di incrementare la produttività e allo stesso tempo soddisfare la richiesta dei consumatori di prodotti di elevata qualità. A tal fine, si possono proporre alle aziende lattiero-casearie nuovi metodi per migliorare la comprensione e il monitoraggio dei processi di produzione. La Process Analytical Technology (PAT) rappresenta uno strumento ideale per raggiungere questo scopo, grazie a sensori in grado di eseguire analisi rapide, green, non distruttive ed in tempo reale. Le tecniche più utilizzate in questo campo sono la
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3

HAUSMAN-MANNING, DEBRA SUE. "APPLICATION OF PROCESS ANALYTICAL TECHNOLOGY TO PHARMACEUTICAL PROCESSES." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1108838053.

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4

Stanke, Marc [Verfasser], and Bernd [Akademischer Betreuer] Hitzmann. "Process analytical technology in food biotechnology / Marc Stanke ; Betreuer: Bernd Hitzmann." Hohenheim : Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim, 2019. http://d-nb.info/1176624881/34.

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5

Hunnicutt, Leigh Anne. "Investigating late stage biopharmaceutical product loss using novel analytical and process technology." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/43837.

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Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Biological Engineering Division; in conjunction with the Leaders for Manufacturing Program at MIT, 2008.<br>MIT Institute Archives copy: pages, 85-86, 87-88, 89-90 bound in reverse order.<br>Includes bibliographical references (p. 79-83).<br>The biopharmaceutical industry uses recombinant protein technologies to provide novel therapeutics to patients around the world. These technologies have presented exciting opportunities for breakthrough medical treatments
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6

Adedipe, Oluwatosin Emmanuel. "Application of process analytical technology to wood a near infrared spectroscopy approach /." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=6037.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains xi, 98 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 47-52).
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7

Medendorp, Joseph Peter. "CHEMOMETRICS, SPECTROMETRY, AND SENSORS FOR INTEGRATED SENSING AND PROCESSING: ADVANCING PROCESS ANALYTICAL TECHNOLOGY." Lexington, Ky. : [University of Kentucky Libraries], 2006. http://lib.uky.edu/ETD/ukyphsc2006d00464/JPMv4.pdf.

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Thesis (Ph. D.)--University of Kentucky, 2006.<br>Title from document title page (viewed on August 22, 2006). Document formatted into pages; contains: xvi, 229 p. : ill. (some col.). Includes abstract and vita. Includes bibliographical references (p. 213-227).
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8

Gola, Benjamin [Verfasser]. "Quality by design and process analytical technology zur Herstellung bioaktiver Proteine / Benjamin Gola." Hannover : Technische Informationsbibliothek (TIB), 2016. http://d-nb.info/1126666300/34.

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9

Howard, Krystel S. "Process analytical technology investigation of the crystallization of pharmaceutical polymorphs, salts and hydrates." Thesis, Loughborough University, 2011. https://dspace.lboro.ac.uk/2134/8464.

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Pharmaceutical industries aim for continuous improvement in the manufacturing process of producing medicines. Demands on the pharmaceutical industries are to produce quality products in a quick and cost effective way. Designing a robust crystallization process so as to produce quality crystals with the desired polymorphic form, morphology, size and size distribution, will contribute towards meeting these demands. The Food and Drug Administration regulating body encourages the development of quality by design (QbD) approaches, involving the use of process analytical technology (PAT) for the des
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10

COLUCCI, DOMENICO. "Infrared Imaging: a New Process Analytical Technology for Real Time Monitoring and Control of a Freeze-Drying Process." Doctoral thesis, Politecnico di Torino, 2020. http://hdl.handle.net/11583/2823943.

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11

Schneid, Stefan Christian. "Investigation of novel process analytical technology (PAT) tools for use in freeze-drying processes." kostenfrei, 2009. http://d-nb.info/999755315/34.

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12

Rüdt, Matthias Roman [Verfasser], and J. [Akademischer Betreuer] Hubbuch. "Spectroscopy as Process Analytical Technology for Preparative Protein Purification / Matthias Roman Rüdt ; Betreuer: J. Hubbuch." Karlsruhe : KIT-Bibliothek, 2019. http://d-nb.info/1174992247/34.

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13

Arshad, Muhammad Sohail. "Application of through-vial impedance spectroscopy as a novel process analytical technology for freeze drying." Thesis, De Montfort University, 2014. http://hdl.handle.net/2086/10407.

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This study aims to validate and develop applications for a novel impedance-based process analytical technology for monitoring the attributes of the product during the entire freeze-drying process (from pre-freezing and annealing to primary and then secondary drying). This measurement approach involves the application of foil electrodes, mounted externally to a conventional glass freeze-drying vial, and coupled to a high-impedance analyser. The location of the electrodes on the outside, rather than the inside of the vial, leads to a description of the technology as a through-vial impedance spec
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14

Rüdt, Matthias [Verfasser], and J. [Akademischer Betreuer] Hubbuch. "Spectroscopy as Process Analytical Technology for Preparative Protein Purification / Matthias Roman Rüdt ; Betreuer: J. Hubbuch." Karlsruhe : KIT-Bibliothek, 2019. http://d-nb.info/1174992247/34.

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15

Metze, Sabrina [Verfasser]. "Scalability of single-use biopharmaceutical manufacturing processes using process analytical technology (PAT) tools / Sabrina Metze." Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2020. http://d-nb.info/1204459495/34.

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16

Dai, Bin. "SIMULATIONS-GUIDED DESIGN OF PROCESS ANALYTICAL SENSOR USING MOLECULAR FACTOR COMPUTING." UKnowledge, 2007. http://uknowledge.uky.edu/gradschool_diss/483.

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Many areas of science now generate huge volumes of data that present visualization, modeling, and interpretation challenges. Methods for effectively representing the original data in a reduced coordinate space are therefore receiving much attention. The purpose of this research is to test the hypothesis that molecular computing of vectors for transformation matrices enables spectra to be represented in any arbitrary coordinate system. New coordinate systems are selected to reduce the dimensionality of the spectral hyperspace and simplify the mechanical/electrical/computational construction of
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17

Steigmiller, Daniela [Verfasser]. "Application of Process Analytical Technology for Investigation of Fluid Bed Granulation and Active Coating during Process Development and Scale-up / Daniela Steigmiller." Bonn : Universitäts- und Landesbibliothek Bonn, 2012. http://d-nb.info/1044866624/34.

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18

Naicker, Krishnaveni. "An investigation into the introduction of process analytical technology, using near infrared analysis, to selected pharmaceutical processes." Thesis, Nelson Mandela Metropolitan University, 2007. http://hdl.handle.net/10948/577.

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Introduction: Process analytical technologies are systems for the analysis and control of manufacturing processes to assure acceptable end-product quality. This is achieved by timely measurements of critical parameters and performance attributes of raw material and in-process material and processes. The introduction of process analytical technology using near infrared analysis was investigated in three areas, namely incoming raw material analysis, blend uniformity analysis and moisture determination in the fluid bed dryer. Methodology: Incoming raw material identification - The FOSS XDS rapid
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19

Vormittag, Philipp [Verfasser], and J. [Akademischer Betreuer] Hubbuch. "Data-Driven Process Development for Virus-Like Particles - Implementation of Process Analytical Technology, Molecular Modeling, and Machine Learning / Philipp Vormittag ; Betreuer: J. Hubbuch." Karlsruhe : KIT-Bibliothek, 2020. http://d-nb.info/122118699X/34.

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20

Grout, B. F. "Novel applications of at-line near-infrared spectroscopy as process analytical technology for solid dosage form pharmaceutical analysis." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1395997/.

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The principal aim of this research was to assess at-line Near Infrared Spectroscopy (NIRS) to support Process Analytical Technology (PAT) applications within solid dosage form manufacturing. The history of PAT was traced from implementation of process analytical applications prior to the 2003 United States, Food and Drug Administration PAT initiative through to current time. The use of NIRS within the PAT context was reviewed, highlighting two areas in solid dosage manufacturing where further research of at-line NIRS is warranted; material testing and finished dosage form analysis. Novel appli
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21

Alexander, Rodney T. "Can the analytical hierarchy process model be effectively applied in the prioritization of information assurance defense in-depth measures? - a quantitative study." Thesis, Capella University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10257625.

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<p> Organizational computing devices are increasingly becoming targets of cyber-attacks, and organizations have become dependent on the safety and security of their computer networks and their organizational computing devices. Business and government often use defense in-depth information assurance measures such as firewalls, intrusion detection systems, and password procedures across their enterprises to plan strategically and manage IT security risks. This quantitative study explores whether the analytical hierarchy process (AHP) model can be effectively applied to the prioritization of info
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22

Sundström, Heléne. "Analytical tools for monitoring and control of fermentation processes." Doctoral thesis, KTH, Skolan för bioteknologi (BIO), 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4531.

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The overall objective of this work has been to adopt new developments and techniques in the area of measurement, modelling and control of fermentation processes. Flow cytometry and software sensors are techniques which were considered ready for application and the focus was set on developing tools for research aiming at understanding the relationship between measured variables and process quality parameters. In this study fed-batch cultivations have been performed with two different strains of Escherichia coli (E.coli) K12 W3110 with and without a gene for the recombinant protein promegapoieti
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23

Sukowski, Lars. "NIR based process analytical technology: in-line residual moisture determination for a complete batch inspection of lyophilized end-products." Basel : Universität Basel, 2003. http://www.unibas.ch/diss/2003/DissB_6601.htm.

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24

Tumuluri, Venkat S. "Quantitation of pharmaceutical formulations and monitoring of pharmaceutical processes using process analytical technology techniques : near infrared and Raman spectroscopy /." Full text available from ProQuest UM Digital Dissertations, 2007. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1414121171&SrchMode=1&sid=7&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1220637804&clientId=22256.

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25

Abu, Bakar Mohd R. "Process analytical technology based approaches for the monitoring and control of size and polymorphic form in pharmaceutical crystallisation processes." Thesis, Loughborough University, 2010. https://dspace.lboro.ac.uk/2134/6436.

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Pharmaceutical crystallisation operation is often critical because it determines product properties, such as the crystal size distribution (CSD) and polymorphic form, that can influence the subsequent downstream operations and the product therapeutic performance. Driven by the United States Food and Drug Administration s (FDA) Process Analytical Technology (PAT) initiative and the Quality-by-Design (QbD) concept, the development of control approaches, which can improve the manufacturing of products with desired properties, has become of significant interest. This thesis presents the developmen
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26

Bakker, Naomi Michelle, and Jonas Bomans. "Uncovering the cause of pre-analytical errors in the blood sampling process: a framework." Thesis, KTH, Skolan för industriell teknik och management (ITM), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-300167.

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Since laboratory tests influence as much as 70% of the medical decisions, errors throughout the blood sampling process may jeopardize the safety of the patient. Research has shown that the pre-analytical phase of the blood sampling process is where the most errors occur. Moreover, this phase is said to be the most influential part of the total testing process, due to maximal involvement of humans. In this study, the pre-analytical errors in the blood sample handling process and their causes were investigated. Therefore, a literature study was performed, and first-hand data was collected throug
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27

Lin, Haisheng. "The application of multivariate statistical analysis and batch process control in industrial processes." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/the-application-of-multivariate-statistical-analysis-and-batch-process-control-in-industrial-processes(a80fba25-82b1-4f55-a38e-c486262e18dd).html.

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To manufacture safe, effective and affordable medicines with greater efficiency, process analytical technology (PAT) has been introduced by the Food and Drug Agency to encourage the pharmaceutical industry to develop and design well-understood processes. PAT requires chemical imaging techniques to be used to collect process variables for real-time process analysis. Multivariate statistical analysis tools and process control tools are important for implementing PAT in the development and manufacture of pharmaceuticals as they enable information to be extracted from the PAT measurements. Multiva
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28

Lemos, Ana Filipa Fontelonga de. "A Process Analytical Technology Approach Based on Spectroscopic Techniques and Multivariate Data Analysis: Quantifying Ternary Mixtures of Amlodipine Besylate Solid Forms." Master's thesis, Faculdade de Farmácia da Universidade do Porto, 2009. http://hdl.handle.net/10216/23498.

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29

Simone, Elena. "Application of process analytical technology (PAT) tools for the better understanding and control of the crystallization of polymorphic and impure systems." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/20098.

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This work presents a comprehensive study on the application of PAT tools to study, monitor and control polymorphism during batch cooling crystallization processes. For the first time, the same techniques were used to control and adjust polymorphic purity of the solid phase but also to investigate the relation between chemical equilibrium in solution and polymorphic outcome of cooling crystallization. Crystallization is an important unit operation used as separation and purification technique. It is widely employed in the pharmaceutical, chemical, agrochemical, food and cosmetics industries but
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30

Lemos, Ana Filipa Fontelonga de. "A Process Analytical Technology Approach Based on Spectroscopic Techniques and Multivariate Data Analysis: Quantifying Ternary Mixtures of Amlodipine Besylate Solid Forms." Dissertação, Faculdade de Farmácia da Universidade do Porto, 2009. http://hdl.handle.net/10216/23498.

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31

Kim, Mijin. "Exploring housing preference of young adults– With focus on largest cities in Sweden." Thesis, KTH, Fastigheter och byggande, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-277882.

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For the last decades, numerous researchers have studied housing preferences of populations. However, very few researchers put highlight on young adults in Sweden and their housing preference. From a Swedish perspective, it is worthwhile to investigate housing preferences of young adults as the populationof young adults is consistently growing and their roles as dynamic consumers are crucial in the housing market. This thesis aims to examine housing preference of young adults aged 18 to 30 in largest cities in Sweden by comparison to older age groups. By identifying housing attributes highly va
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32

Apshingekar, Prafulla P. "Applications of ultrasound in pharmaceutical processing and analytics." Thesis, University of Bradford, 2014. http://hdl.handle.net/10454/14127.

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Innovations and process understanding is the current focus in pharmaceutical industry. The objective of this research was to explore application of high power ultrasound in the slurry crystallisation and application of low power ultrasound (3.5 MHz) as process analytical technology (PAT) tool to understand pharmaceutical processing such as hot melt extrusion. The effect of high power ultrasound (20 kHz) on slurry co-crystallisation of caffeine / maleic acid and carbamazepine / saccharin was investigated. To validate low power ultrasound monitoring technique, it was compared with the other tech
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33

Banedar, Parineeta Namdeo. "A Raman spectroscopic study of solid dispersions and co-crystals during the pharmaceutical hot melt extrusion process." Thesis, University of Bradford, 2015. http://hdl.handle.net/10454/14365.

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Process Analytical Technology (PAT) is framed with the objective of the design and development of processes to ensure predefined quality of the product at the end of manufacturing. PAT implementation includes better understanding of process, reduction in production time with use of in-line, at-line and on-line measurements, yield improvement and energy and cost reductions. Hot Melt Extrusion process (HME) used in the present work is proving increasingly popular in industry for its continuous and green processing which is beneficial over traditional batch processing. The present work was focuse
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34

Banedar, Parineeta N. "A Raman Spectroscopic Study of Solid Dispersions and Co-crystals During the Pharmaceutical Hot melt Extrusion Process." Thesis, University of Bradford, 2015. http://hdl.handle.net/10454/14365.

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Process Analytical Technology (PAT) is framed with the objective of the design and development of processes to ensure predefined quality of the product at the end of manufacturing. PAT implementation includes better understanding of process, reduction in production time with use of in-line, at-line and on-line measurements, yield improvement and energy and cost reductions. Hot Melt Extrusion process (HME) used in the present work is proving increasingly popular in industry for its continuous and green processing which is beneficial over traditional batch processing. The present work was focus
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35

Gendre, Claire. "Process Analytical Technology : suivi en temps réel d’une opération d’enrobage et de curing et nouvelles avancées dans la caractérisation du film polymère." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA114836/document.

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La mise en place de la démarche PAT (Process Analytical Technology), initiée par la FDA (Food and Drug Administration) s’est développée au cours de ces dernières années, au sein de l’industrie pharmaceutique. Grâce à des contrôles en continu au coeur des procédés de fabrication, elle permet une meilleure compréhension et une maîtrise de la formulation et du procédé, afin d’assurer la qualité finale des médicaments.A travers ce travail, nous avons mis en place un suivi en temps réel, par spectroscopie proche infrarouge, d’une opération d’enrobage suite à l’intégration d’une sonde à l’intérieur
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36

Gnoth, Stefan [Verfasser], Andreas [Akademischer Betreuer] Lübbert, and Jochen [Akademischer Betreuer] Büchs. "Implementation of process analytical technology tools in microbial fermentation processes for recombinant therapeutic protein production / Stefan Gnoth. Betreuer: Andreas Lübbert ; Jochen Büchs." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2011. http://d-nb.info/1025135180/34.

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37

Gendre, Claire. "Process Analytical Technology : suivi en temps réel d'une opération d'enrobage et de curing et nouvelles avancées dans la caractérisation du film polymère." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00703141.

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La mise en place de la démarche PAT (Process Analytical Technology), initiée par la FDA (Food and Drug Administration) s'est développée au cours de ces dernières années, au sein de l'industrie pharmaceutique. Grâce à des contrôles en continu au coeur des procédés de fabrication, elle permet une meilleure compréhension et une maîtrise de la formulation et du procédé, afin d'assurer la qualité finale des médicaments.A travers ce travail, nous avons mis en place un suivi en temps réel, par spectroscopie proche infrarouge, d'une opération d'enrobage suite à l'intégration d'une sonde à l'intérieur
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38

Urbas, Aaron Andrew. "ANISOTROPIC POLARIZED LIGHT SCATTER AND MOLECULAR FACTOR COMPUTING IN PHARMACEUTICAL CLEANING VALIDATION AND BIOMEDICAL SPECTROSCOPY." UKnowledge, 2007. http://uknowledge.uky.edu/gradschool_diss/526.

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Spectroscopy and other optical methods can often be employed with limited or no sample preparation, making them well suited for in situ and in vivo analysis. This dissertation focuses on the use of a near-infrared spectroscopy (NIRS) and polarized light scatter for two such applications: the assessment of cardiovascular disease, and the validation of cleaning processes for pharmaceutical equipment.There is a need for more effective in vivo techniques for assessing intravascular disorders, such as aortic aneurysms and vulnerable atherosclerotic plaques. These, and other cardiovascular disorders
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39

Schaefer, Cédric. "A Process Analytical Technology (PAT) approach involving near infrared spectroscopy to control the manufacturing of an active pharmaceutical ingredient : development, validation and implementation." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4375.

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Les entreprises pharmaceutiques ont progressivement adopté le concept de Process Analytical Technology (PAT) afin de contrôler et d'assurer en temps réel la qualité des produits pharmaceutiques au cours de leur production. Le PAT et un composant central du concept plus général de Quality-by-Design (QbD) promu par les agence régulatrices et visant à construire la qualité des produits via une approche scientifique et la gestion des risques.Une méthode basée sur la spectroscopie proche infrarouge (PIR) a été développée comme un outil du PAT pour contrôler en ligne la cristallisation d'un principe
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40

Schaefer, Cédric. "A Process Analytical Technology (PAT) approach involving near infrared spectroscopy to control the manufacturing of an active pharmaceutical ingredient : development, validation and implementation." Electronic Thesis or Diss., Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4375.

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Les entreprises pharmaceutiques ont progressivement adopté le concept de Process Analytical Technology (PAT) afin de contrôler et d'assurer en temps réel la qualité des produits pharmaceutiques au cours de leur production. Le PAT et un composant central du concept plus général de Quality-by-Design (QbD) promu par les agence régulatrices et visant à construire la qualité des produits via une approche scientifique et la gestion des risques.Une méthode basée sur la spectroscopie proche infrarouge (PIR) a été développée comme un outil du PAT pour contrôler en ligne la cristallisation d'un principe
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41

Li, Qing. "Game Theoretic and Analytical Approaches to International Cooperation and Investment Problems." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/32406.

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International cooperation and foreign investment issues are two important components of an international economy. The various aspects of research related to such international cooperation and foreign investment decisions are fraught with various complex factors. In this thesis, we consider two specific issues in the arena of international technological cooperation and foreign investments, by using established Operations Research techniques of game theory and multiple criteria decision making. We first analyze regional technological cooperation mechanisms using classical game theory. A concep
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42

Mohammad, Alamgir Hossain. "Adoption, continued, and extended use of radio frequency identification (RFID) technology : Australian Livestock Industry." Thesis, Curtin University, 2012. http://hdl.handle.net/20.500.11937/1766.

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In general, the adoption and diffusion of Information Systems (IS) in agriculture industry is a neglected issue in academia, let alone the livestock sector. In livestock industry, Radio Frequency Identification (RFID) technology is currently used in order to ensure meat safety. Generally, the livestock supply chain involves a large number of people and organisations/farms. To ensure a successful animal-tracing system, the examination of the adoption behaviour of those stakeholders is worthwhile. So far, no initiative has been made by the researchers to investigate the adoption process and rele
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43

Zavala, Ortiz Daniel. "Application of in situ near infra-red spectroscopy (NIRS) for monitoring biopharmaceuticals production by cell cultures." Electronic Thesis or Diss., Université de Lorraine, 2020. http://www.theses.fr/2020LORR0040.

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La complexité des médicaments biopharmaceutiques implique que leur validation par les instances réglementaires nécessite un processus spécifique. Tout changement, notamment du procédé, nécessite une nouvelle validation en termes d’efficacité clinique et de sécurité pour le patient. Puisque les changements dans le procédé sont parfois inévitables, la qualité du produit n’a plus à être évaluée uniquement en fin de procédé de production (Quality by testing, QbT), mais tout au long du procédé, et conceptualisée dans toutes les étapes de fabrication (Quality by Design, QbD). Cette démarche préconis
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44

Link, David John. "BOOTSTRAP ENHANCED N-DIMENSIONAL DEFORMATION OF SPACE WITH ACOUSTIC RESONANCE SPECTROSCOPY." UKnowledge, 2009. http://uknowledge.uky.edu/gradschool_diss/728.

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Acoustic methods can often be used with limited or no sample preparations making them ideal for rapid process analytical technologies (PATs). This dissertation focuses on the possible use of acoustic resonance spectroscopy as a PAT in the pharmaceutical industry. Current good manufacturing processes (cGMP) need new technologies that have the ability to perform quality assurance testing on all products. ARS is a rapid and non destructive method that has been used to perform qualitative studies but has a major drawback when it comes to quantitative studies. Acoustic methods create highly non lin
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45

Hannel, Thaddaeus S. "PATTERN RECOGNITION INTEGRATED SENSING METHODOLOGIES (PRISMS) IN PHARMACEUTICAL PROCESS VALIDATION, REMOTE SENSING AND ASTROBIOLOGY." UKnowledge, 2009. http://uknowledge.uky.edu/gradschool_diss/751.

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Modern analytical instrumentation is capable of creating enormous and complex volumes of data. Analysis of large data volumes are complicated by lengthy analysis time and high computational demand. Incorporating real-time analysis methods that are computationally efficient are desirable for modern analytical methods to be fully utilized. The use of modern instrumentation in on-line pharmaceutical process validation, remote sensing, and astrobiology applications requires real-time analysis methods that are computationally efficient. Integrated sensing and processing (ISP) is a method for minimi
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46

Helmdach, Lydia Verfasser], Joachim [Akademischer Betreuer] Ulrich, Martin [Akademischer Betreuer] Feth, and Ulrich [Akademischer Betreuer] [Teipel. "Application of process analytical technology (PAT) tools to develop and monitor scalable crystallization processes of pharmaceuticals / Lydia Helmdach. Betreuer: Joachim Ulrich ; Martin Feth ; Ulrich Teipel." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2013. http://d-nb.info/1046563432/34.

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Kornecki, Martin Lukas [Verfasser], Jochen [Akademischer Betreuer] Strube, and Udo [Akademischer Betreuer] Rau. "Methoden zur Integration von Upstream und Downstream Processing für Biologics hinsichtlich Prozessentwicklung, Digital Twin und Process Analytical Technology / Martin Lukas Kornecki ; Jochen Strube, Udo Rau." Clausthal-Zellerfeld : Technische Universität Clausthal, 2020. http://d-nb.info/1231362537/34.

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Trevisan, Marcello Garcia. "Monitoramento de reações quimicas empregando espectroscopia no infravermelho." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249328.

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Orientador: Ronei Jesus Poppi<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-08-13T21:27:37Z (GMT). No. of bitstreams: 1 Trevisan_MarcelloGarcia_D.pdf: 3921294 bytes, checksum: 59fe442f53af8cb6eaeb8166b7b6980f (MD5) Previous issue date: 2009<br>Resumo: Esta tese tem como objetivo desenvolver um conjunto de metodologias que incorporem a utilização da espectroscopia na região do infravermelho médio/próximo com métodos de estatística multivariada (quimiometria) em aplicações com enfoque em Química Analítica de Processos (QAP). P
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Engelhard, Sonja, Michael U. Kumke, and Hans-Gerd Löhmannsröben. "OPQS – optical process and quality sensing : exemplary applications in the beerbrewing and polyurethane foaming processes." Universität Potsdam, 2006. http://opus.kobv.de/ubp/volltexte/2007/1219/.

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Optical methods play an important role in process analytical technologies (PAT). Four examples of optical process and quality sensing (OPQS) are presented, which are based on three important experimental techniques: near-infrared absorption, luminescence quenching, and a novel method, photon density wave (PDW) spectroscopy. These are used to evaluate four process and quality parameters related to beer brewing and polyurethane (PU) foaming processes: the ethanol content and the oxygen (O2) content in beer, the biomass in a bioreactor, and the cellular structures of PU foam produced in a pilot p
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Krantz, Evelina. "AHP applicerat på fastighetsköp i Spanien : En tillämpning av Analytical Hierarchy Process och en överblick av spanska regler kring fastighetsköp som EU-medborgare." Thesis, KTH, Fastigheter och byggande, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-211074.

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Den spanska fastighetsmarknaden är på uppgång då fastighetspriserna ökar igen efter den globala finanskrisen 2008. Den här uppsatsen syftar både till att lösa ett fabricerat investeringsproblem med hjälp av AHP, Analytical Hierarchy Process, och till att undersöka hur processen av ett fastighetsköp som EU-medborgare kan se ut gällande lagar och regler.  Investeringsproblemet består utav att välja en av tre fastigheter, alla radhus med olika egenskaper lokaliserade i olika delar av Valencia på den spanska östkusten, baserat på resultatet från en  enkätundersökning utförd på plats i staden med e
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