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Journal articles on the topic 'Prochlorperazine maleate'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Blazheyevskiy, M. Ye, and V. P. Moroz. "The Oxidative Derivatization Method For The Indirect Spectrophotometric Determination Of Prochlorperazine In Tablets." Methods and Objects of Chemical Analysis 15, no. 3 (2020): 132–36. http://dx.doi.org/10.17721/moca.2020.132-136.

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The oxidative derivatization method by means of peroxoacid for the indirect spectrophotometric determination of Prochlorperazine Maleate is presented. Potassium hydrogen peroxymonosulfate as a derivatizing agent, yielding the Prochlorperazine sulfoxide with λmaх=338 nm is proposed. This reaction product was successfully employed for the spectrophotometric determination of the Prochlorperazine Maleate. The UV spectrophotometric determination of Prochlorperazinе as its sulfoxide proved to be the more robust and selective method. Concentration dependence of the oxidation product remains linear in

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2

Blazheyevskiy, M. Ye, Yu V. Skrypynets, A. V. Yegorova, and V. P. Antonovich. "A New Oxidative Derivatization Method For The Indirect Spectrofluorimetric Determination Of Prochlorperazine Maleate In Pharmaceutical Preparations." Methods and Objects of Chemical Analysis 14, no. 3 (2019): 140–45. http://dx.doi.org/10.17721/moca.2019.140-145.

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A new oxidative derivatization method for the indirect spectrofluorimetric determination of Prochlorperazine maleate has been presented. Potassium hydrogenperoxomonosulphate is proposed as a derivatizing agent for Prochlorperazine, yielding the strongly fluorescent sulfoxide. This reaction product was successfully employed for the spectrofluorimetric determination of the Prochlorperazine maleate. A highly sensitive, simple and rapid method has been developed for determining prochlorperazine maleate in tablets by fluorescence of its oxidation product with Oxone solution in 0.01 M sulfuric acid

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3

Bhagwat, G. B., S. P. Wate, and A. S. Mundhey. "DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF PROCHLORPERAZINE MALEATE AND PYRIDOXINE HYDROCHLORIDE IN TABLET DOSAGE FORM BY UV USING MULTI-COMPONENT MODE OF ANALYSIS." INDIAN DRUGS 50, no. 03 (2013): 20–25. http://dx.doi.org/10.53879/id.50.03.p0020.

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Prochlorperazine maleate and pyridoxine hydrochloride in combination are available as tablet dosage forms in the ratio of 1:5. A simple, reproducible and efficient method for the simultaneous determination of prochlorperazine maleate and pyridoxine hydrochloride in tablet dosage form has been developed. The developed method is based on the simultaneous estimation by UV Spectroscopy, using multi-component mode of analysis. In this method 0.3M HCl was used as solvent. Wavelengths selected for estimation of prochlorperazine maleate and pyridoxine hydrochloride in multi-component mode of analysis

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4

Pawar, Rajat, Ravi Sharma, and Gajanan Darwhekar. "Formulation and Evaluation of Mouth Dissolving Film of Prochlorperazine Maleate." Journal of Drug Delivery and Therapeutics 9, no. 6 (2019): 110–15. http://dx.doi.org/10.22270/jddt.v9i6.3679.

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This research work was aimed to enhance the oral bioavailability and provide faster onset of action of Prochlorperazine maleate (used for the treatment nausea and vomiting) by formulating its mouth dissolving film (MDF). Prochlorperazine belongs to BCS II and oral bioavailability of it’s about 11-15%. The MDF of Prochlorperazine maleate was prepared by solvent casting method using HPMC (film forming agent),Glycerol (plasticizer), Betacyclodextrin (solubilizing agent), Citric acid (saliva stimulating agent), Mannitol (sweetening agent). The formulation was optimized by two factors, three levels

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5

Sharma, Shailesh. "Development of Fast Dissolving Buccal Patches of Prochlorperazine Maleate for Effective Management of Emesis." YMER Digital 21, no. 08 (2022): 123–36. http://dx.doi.org/10.37896/ymer21.08/13.

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The goal of this research was to increase the oral bioavailability and avoid the first pass metabolism of Prochlorperazine Maleate (used to treat nausea and vomiting) by creating its buccal patches. Prochlorperazine is a member of BCS II and has an oral bioavailability of 11– 15%. Prochlorperazine maleate buccal patches were made by solvent casting with the aid of HPMC E-15 and Chitosan (film-forming agents), Glycerol (plasticizer), Tween 80 (penetration enhancer), Citric Acid (saliva stimulating agent), Mannitol (sweetening agent), and Ethyl Cellulose (Backing membrane). Twelve total formulat

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6

Meena, Aarti, Sunita Patidar, Rajat Pawar, and P. K. Dubey. "FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLET OF PROCHLORPERAZINE MALEATE." International Journal of Pharmaceutical Sciences and Medicine 9, no. 2 (2024): 76–104. http://dx.doi.org/10.47760/ijpsm.2024.v09i02.009.

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In the present work, fast disintegrating tablets of prochlorperazine maleate were designed with a view to enhance patient compliance by effervescent method. Prochlorperazine Maleate, a potent antipsychotic medication with antiemetic properties, holds significance in treating various conditions such as nausea, vomiting, and vertigo. The decision to formulate it into orodispersible tablets aimed to address issues related to patient compliance and convenience, particularly for individuals who experience difficulty swallowing conventional tablets. Formulation F10, enriched with 10% Croscarmellose

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7

Chandan, Nakum*¬ Harpal Makwana Vaishali Karkhanis Hina Bagada. "Stability Indicating Assay Method Development and Validation of HPTLC Method for Estimation of Prochlorperazine maleate in Bulk and Tablet Dosage Form." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1957–72. https://doi.org/10.5281/zenodo.15057985.

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Prochlorperazine maleate is an Antiemetic and Antipsychotic Tranquilizer. It is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such as generalized non-psychotic anxiety and schizophrenia. An extensive literature surveys reveals that various analytical methods have been reported for the estimation of Prochlorperazine maleate in API and pharmaceutical dosage form. So, it was thought to develop simple, precise, accurate and specific stability indicating HPTLC method for the estimation of Prochlorperazine maleate in API & pharmaceu

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8

Albadry, Ahmed Abdulameer, Wedad K. Ali, and Fouad A. Al-saady. "FORMULATION AND EVALUATION OF PROCHLORPERAZINE MALEATE SUSTAINED RELEASE FLOATING TABLET." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 2 (2017): 89. http://dx.doi.org/10.22159/ijpps.2017v9i2.15665.

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<p><strong>Objective: </strong>The objective of this study was to formulate once daily sustained oral release floating tablet of prochlorperazine maleate, this floating tablet has many advantages like reduction in dosing frequency, increase bioavailability, enhance patient compliance, and improve drug solubility.</p><p><strong>Methods: </strong>The prochlorperazine maleate floating tablets were formulated by using hydrophilic swellable polymer and gas generating agent. In this study, 15 formulas were prepared with many variables in order to achieve an

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9

Tokola, Riitta A. "The Effect of Metoclopramide and Prochlorperazine on the Absorption of Effervescent Paracetamol in Migraine." Cephalalgia 8, no. 3 (1988): 139–47. http://dx.doi.org/10.1046/j.1468-2982.1988.0803113.x.

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Antiemetics modify gastric emptying, a rate-limiting step in drug absorption. The absorption of effervescent paracetamol in water solution was studied in three groups of 10 female patients during acute migraine attacks. Paracetamol was preceded 30 min earlier by a rectal dose of metoclopramide, prochlorperazine maleate, or placebo. Each patient was retested with paracetamol when headache-free. Migraine attacks delayed slightly the absorption of paracetamol solution. Prior administration of rectal prochlorperazine had a minor delaying effect on paracetamol absorption. The peak concentration, th

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10

Shrisunder, Nikhil, Prashant Kumar Dhakad, and Ritu Gilhotra. "Novel RP-HPLC method development and validation for precise quantification of prochlorperazine maleate in pharmaceutical dosage forms." Journal of Applied Pharmaceutical Research 13, no. 1 (2025): 112–22. https://doi.org/10.69857/joapr.v13i1.782.

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Background: Prochlorperazine Maleate, a piperazine phenothiazine derivative, exhibits strong antiemetic and antipsychotic properties. However, existing analytical methods for its quantification in pharmaceutical formulations often face limitations regarding sensitivity, specificity, and accuracy. Many conventional techniques involve extensive sample preparation and prolonged analysis times, making them less feasible for high-throughput quality control. This study developed and validated a novel, precise, and highly sensitive reverse-phase high-performance liquid chromatography (RP-HPLC) method

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11

Aman, Tehseen, Zeeshan Majeed, Asrar Ahmad Kazi, and Islam Ullah Khan. "Spectrophotometric Determination of Prochlorperazine Maleate in Pure and Pharmaceutical Preparations." Microchimica Acta 138, no. 1-2 (2002): 13–17. http://dx.doi.org/10.1007/s006040200001.

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12

JOSHI, PARAMJIT, JOSEPH T. COYLE, and JOSEPH CAPOZZOLI. "In Reply: Neuroleptic Malignant Syndrome." Pediatrics 88, no. 5 (1991): 1074. http://dx.doi.org/10.1542/peds.88.5.1074a.

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We appreciate the letter of Dr Edwards, which draws attention to the potential risk of antiemetics for causing neuroleptic malignant syndrome (NMS). As we indicated in our article, the mechanism of action shared by drugs that cause NMS is blockade of brain dopamine receptors. Antiemetics, commonly used in pediatrics, such as prochlorperazine maleate and metoclopramide, act by blocking central dopamine receptors and have a propensity for precipitating acute extrapyramidal symptoms, ie, dystonic reaction. Dehydration is a frequent complication of recurrent vomiting in children, that is an indica

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13

Shirsand, SB, Sarasija Suresh, MS Para, and PV Swamy. "Design of fast disintegrating tablets of prochlorperazine maleate by effervescence method." Indian Journal of Pharmaceutical Sciences 71, no. 4 (2009): 447. http://dx.doi.org/10.4103/0250-474x.57298.

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14

Kanekar, R., P. M. Dandagi, and A. P. Gadad. "FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILMS OF PROCHLORPERAZINE MALEATE." INDIAN DRUGS 52, no. 12 (2015): 23–33. http://dx.doi.org/10.53879/id.52.12.10351.

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The objective of the present study was to prepare and evaluate fast-dissolving oral films of prochlorperazine maleate (PCM), in order to enhance the bioavailability of the drug and to provide rapid onset of action thereby improving patient compliance. The solubility of the drug was increased by preparing inclusion complex with 2-hydroxypropyl-β-cyclodextrin (2HPβCD) and then incorporating it into the fast dissolving films. The fast-dissolving films of PCM were prepared by solvent casting method using different film forming polymers such as HPMC E15 and HPMC E5, either as single polymer or comb

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15

Nagarsenker, M. S., and S. D. Garad. "Physical characterization and optimisation of dissolution parameters of prochlorperazine maleate coevaporates." International Journal of Pharmaceutics 160, no. 2 (1998): 251–55. http://dx.doi.org/10.1016/s0378-5173(97)00318-9.

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16

Jagdale, Swati C., and Aleesha B. Randhave. "Hydroxyl Ethyl Cellulose HHX and Polymethyl Methacrylate Based Site Specific Floating Delivery of Prochlorperazine Maleate." Open Pharmaceutical Sciences Journal 3, no. 1 (2016): 149–63. http://dx.doi.org/10.2174/1874844901603010149.

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Background:Prochlorperazine maleate is a phenothiazine antipsychotic used principally in the treatment of nausea, vomiting and vertigo. Biological half- life of the drug is about 6 to 8 hrs and oral dose is 5 or 10 mg thrice or four times a day. The mean absolute bioavailability for drug is 12.5%. Due to the solubility of drug in acidic pH, it is mainly absorbed from stomach.Objective:Site specific oral floating delivery of prochlorperazine maleate will prolong the gastric retention time, increases the drug bioavailability, reduces frequency of administration and can result in better patient c

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17

Raval, Mihir, and Hina L. Bagada. "Solubility and Dissolution Study of Prochlorperazine Maleate Nanoparticle Prepared by Design of Experiment." BioNanoScience 11, no. 2 (2021): 567–78. http://dx.doi.org/10.1007/s12668-021-00831-8.

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18

C. Jagdale, Swati, and Aleesha B. Randhave. "Optimization of Natrosol HHX and HPC-H Controlled Floating Delivery for Prochlorperazine Maleate." Current Drug Therapy 11, no. 1 (2016): 70–84. http://dx.doi.org/10.2174/1574885511666160421143932.

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19

Q Almajidi, Yasser, Ahmed A Albaderi, and Hasan Fadhel. "ENHANCE SOLUBILITY AND PROLONG RELEASE OF PROCHLORPERAZINE MALEATE USING FLOATING NANOEMULSION IN SITU GEL." Asian Journal of Pharmaceutical and Clinical Research 12, no. 1 (2019): 537. http://dx.doi.org/10.22159/ajpcr.2018.v12i1.30486.

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Objective: The objective of this study was to prepare floating gastric in situ gel of prochlorperazine maleate (PM) using nanoemulsion technology to improve drug solubility, bioavailability, reduce dosing frequency, and patient compliance.Methods: Eight nanoemulsion formulas (F1–F8) of PM were prepared by ultrasonication method using oil, surfactants: cosurfactants (Smix) with different types, concentrations, and ratios, and deionized distilled water. The nanoemulsion formulas were characterized to select the optimum recipe from which six floating in situ gel formulas (floating nanoemulsion in

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20

Q Almajidi, Yasser, Ahmed A Albaderi, and Hasan Fadhel. "ENHANCE SOLUBILITY AND PROLONG RELEASE OF PROCHLORPERAZINE MALEATE USING FLOATING NANOEMULSION IN SITU GEL." Asian Journal of Pharmaceutical and Clinical Research 12, no. 1 (2019): 537. http://dx.doi.org/10.22159/ajpcr.2019.v12i1.30486.

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Objective: The objective of this study was to prepare floating gastric in situ gel of prochlorperazine maleate (PM) using nanoemulsion technology to improve drug solubility, bioavailability, reduce dosing frequency, and patient compliance.Methods: Eight nanoemulsion formulas (F1–F8) of PM were prepared by ultrasonication method using oil, surfactants: cosurfactants (Smix) with different types, concentrations, and ratios, and deionized distilled water. The nanoemulsion formulas were characterized to select the optimum recipe from which six floating in situ gel formulas (floating nanoemulsion in

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21

Jagdale, Swati, and Mayuri Shinde. "Development of Floating Delivery for Solid Self Micro-Emulsifying Drug Delivery System of Prochlorperazine Maleate." Recent Patents on Drug Delivery & Formulation 11, no. 3 (2018): 198–210. http://dx.doi.org/10.2174/1872211311666171108112349.

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22

Bagada, Hina, Vishva Bhut, and Himaxi Parmar. "Development and Validation of Prochlorperazine Maleate in Bulk and Pharmaceutical Dosage Form by UV Spectroscopic Method." International Journal of Pharmaceutical Investigation 12, no. 3 (2022): 288–92. http://dx.doi.org/10.5530/ijpi.2022.3.50.

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23

Pawashe, Pallavi M., Shital Kumar S. Patil, and Nilofar S. Naikwade. "Prochlorperazine Maleate Loaded Sustained Release Floating Microspheres prepared by Ionotropic Gelation Technique: Morphology and Release Characteristics." Research Journal of Pharmacy and Technology 12, no. 8 (2019): 3866. http://dx.doi.org/10.5958/0974-360x.2019.00664.4.

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24

Yan, Miao, Yun-Gui Zhu, Huan-De Li, et al. "Quantification of prochlorperazine maleate in human plasma by liquid chromatography–mass spectrometry: Application to a bioequivalence study." Journal of Chromatography B 877, no. 27 (2009): 3243–47. http://dx.doi.org/10.1016/j.jchromb.2009.07.038.

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25

D, Nagasamy Venkatesh, Sankar S, S. N. Meyyanathan, K. Elango, B. Suresh, and Santhi K. "Design and Development of Prochlorperazine Maleate Sustained Release Tablets: Influence of Hydrophilic Polymers on the Release rate and In vitro Evaluation." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 2 (2010): 965–77. http://dx.doi.org/10.37285/ijpsn.2010.3.2.10.

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The objective of the present investigation was to develop and evaluate sustained release matrix tablets of prochlorperazine maleate employing different types and levels of hydrophilic matrix agents namely hydroxyl propyl methyl cellulose (HPMC), carbopol and combination of these polymers by wet granulation technique. Prior to compression process, the prepared granules were evaluated for its flow and compression characteristics. The in vitro dissolution of the newly formulated sustained release tablets were compared with standard formulation. The excipients used in this study did not alter the

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26

Bhagwat, Gajanan B., and Manoj Jaybhaye. "Development and Validation of a RP-HPLC Method for the Simultaneous Estimation of Prochlorperazine Maleate and Pyridoxine Hydrochloride in Combined Dosage Forms." Research Journal of Pharmacy and Technology 11, no. 4 (2018): 1338. http://dx.doi.org/10.5958/0974-360x.2018.00249.4.

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27

Badshah, Amir, Fazal Subhan, Nisar Hussain Shah, Nadeem Irfan Bukhari, Muhammad Saeed, and Kifayat Ullah Shah. "Once daily controlled release matrix tablet of Prochlorperazine maleate: Influence of Ethocel®and/or Methocel®onin vitrodrug release and bioavailability." Drug Development and Industrial Pharmacy 38, no. 2 (2011): 190–99. http://dx.doi.org/10.3109/03639045.2011.595416.

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28

Thakur, Shiva Kant, Rahul Pal, Devanand Jha, et al. "The Application of Response Surface Methodology (RSM) In the Computational Optimization of Sustained Release (SR) For Phenothiazine Derivative Matrix Tablet." Journal of Pharmaceutical Research International 35, no. 35 (2023): 13–27. http://dx.doi.org/10.9734/jpri/2023/v35i357483.

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Introduction: This study explores the use of Response Surface Methodology (RSM), a statistical optimization technique, to optimize the SR properties of prochlorperazine maleate (PCM) matrix tablets. PCM is a phenothiazine derivative used for treating schizophrenia, nausea, and vomiting. Sustained-release formulations offer extended drug delivery, potentially improving patient compliance and reducing side effects. RSM helps identify optimal combinations of critical formulation factors influencing drug release, such as polymer type and concentration, filler type, and drug/polymer ratio. The stud

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29

Pund, Suraj B., Vishwas C. Bhagat, Madhuri T. Deshmukh, and Rajkumar V. Shete. "Development and Characterization of Enclosed Prochlorperazine Maleate Floating Alginate Beads." International Journal of Pharmaceutical Sciences Review and Research 68, no. 2 (2021). http://dx.doi.org/10.47583/ijpsrr.2021.v68i02.027.

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The objective of present study aims to formulate enclosed floating alginate beads of Prochlorperazine Maleate (PCZM) for the treatment of nausea and vomiting. The Prochlorperazine Maleate which is having lower bioavailability up to 12.5% and also, it’s a lower biological half-life so which required multiple dosing frequencies 3-4 times a day. Bioavailability refers that to extend and rate at which the active moiety enters into the systemic circulation to the site of action. Biological half-life is the time that a body requires to eliminate one-half the quantity of an administered substance. So

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30

Small, Elan, Harrison Steins, Martin Musi, et al. "Prochlorperazine maleate versus placebo for the prophylaxis of Acute Mountain sickness: a double-blind randomized controlled trial." Journal of Travel Medicine, May 22, 2025. https://doi.org/10.1093/jtm/taaf044.

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Abstract Background Acute mountain sickness (AMS) is a debilitating condition that may occur on ascent to high altitude, with limited options for chemoprophylaxis. The pathophysiology of AMS is poorly understood though may be similar to migraine. This study aimed to determine the efficacy of prochlorperazine, a first-line agent for acute migraine, for AMS prophylaxis. Methods We performed a randomized, double-blind, placebo-controlled trial involving healthy, unacclimatized adult participants, primarily from the Denver area (1609 meters (m)) who received either oral prochlorperazine or placebo

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31

Venkatesh, Dhandapani Nagasamy. "Bioavailability Studies on Developed Prochlorperazine Maleate Sustained Release Tablets by HPLC." Journal of Bioanalysis & Biomedicine 01, no. 01 (2009). http://dx.doi.org/10.4172/1948-593x.1000012.

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32

SHARMA, SHAILESH. "PREPARATION AND EVALUATION OF COPROCESSED SUPERDISINTEGRANT IN THE DESIGN OF PROCHLORPERAZINE MALEATE FAST DISSOLVING TABLETS." Journal of Drug Delivery and Therapeutics 1, no. 2 (2011). http://dx.doi.org/10.22270/jddt.v1i2.35.

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33

Oda, Keiko, Tomohiro Murata, Kayo Tsujimoto, et al. "A case of carcinoid syndrome probably exacerbated by hemodialysis in which prochlorperazine maleate was effective." CEN Case Reports, August 22, 2023. http://dx.doi.org/10.1007/s13730-023-00814-6.

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34

Morris, Stephen, Vicki Salm, and Andrew Salm. "Harm to a child caused by the off-label use of prochlorperazine maleate tablets due to the discontinuation of licensed prochlorperazine mesilate liquid in the UK." European Journal of Hospital Pharmacy, June 14, 2024, ejhpharm-2023-003791. http://dx.doi.org/10.1136/ejhpharm-2023-003791.

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35

Small, Elan, Elizabeth Goldberg, Martin Musi, et al. "Prochlorperazine maleate versus placebo for the prevention of acute mountain sickness: study protocol for a randomized controlled trial." Trials 25, no. 1 (2024). http://dx.doi.org/10.1186/s13063-024-08592-x.

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36

Lyu, Zhiheng, Jiannan Yang, Zhongzhi Xu, et al. "Predicting the risk of ischemic stroke in patients with atrial fibrillation using heterogeneous drug–protein–disease network-based deep learning." APL Bioengineering 9, no. 2 (2025). https://doi.org/10.1063/5.0242570.

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Current risk assessment models for predicting ischemic stroke (IS) in patients with atrial fibrillation (AF) often fail to account for the effects of medications and the complex interactions between drugs, proteins, and diseases. We developed an interpretable deep learning model, the AF-Biological-IS-Path (ABioSPath), to predict one-year IS risk in AF patients by integrating drug–protein–disease pathways with real-world clinical data. Using a heterogeneous multilayer network, ABioSPath identifies mechanisms of drug actions and the propagation of comorbid diseases. By combining mechanistic path

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