Relevant bibliographies by topics / Prochlorperazines

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters

Academic literature on the topic 'Prochlorperazines'

Author: Grafiati
Published: 4 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Prochlorperazines"

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M., Mamatha 1. *. Narendra Babu 2. "SYNTHESIS OF PROCHLOROPERAZINE RELATED COMPOUND A IMPURITY FORMED DURING CHLORPROMAZINE DRUG PREPARATION." Journal of Pharma Research 8, no. 5 (2019): 311–13. https://doi.org/10.5281/zenodo.3236693.

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<strong><em>ABSTRACT</em></strong> <strong><em>I</em></strong><em>n the present work identification and synthesis of Prochlorperazine related compound A impurity in the manufacture of API Chlorpromazine has been reported. Characterization of the product was done by H1 NMR spectral data. Identification of this impurity results in synthesis of pure Prochlorperazines drugs.</em> <strong><em>KEYWORDS</em></strong><em>:&nbsp; Prochlorperazines, Impurity, Sulphur, API drug.</em>
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Blazheyevskiy, M. Ye, and V. P. Moroz. "The Oxidative Derivatization Method For The Indirect Spectrophotometric Determination Of Prochlorperazine In Tablets." Methods and Objects of Chemical Analysis 15, no. 3 (2020): 132–36. http://dx.doi.org/10.17721/moca.2020.132-136.

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The oxidative derivatization method by means of peroxoacid for the indirect spectrophotometric determination of Prochlorperazine Maleate is presented. Potassium hydrogen peroxymonosulfate as a derivatizing agent, yielding the Prochlorperazine sulfoxide with λmaх=338 nm is proposed. This reaction product was successfully employed for the spectrophotometric determination of the Prochlorperazine Maleate. The UV spectrophotometric determination of Prochlorperazinе as its sulfoxide proved to be the more robust and selective method. Concentration dependence of the oxidation product remains linear in
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Van Den Berg, A. A. "The Prophylactic Antiemetic Efficacy of Prochlorperazine and Ondansetron in Nasal Septal Surgery: A Randomized Double-Blind Comparison." Anaesthesia and Intensive Care 24, no. 5 (1996): 538–45. http://dx.doi.org/10.1177/0310057x9602400505.

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A prospective, randomized placebo-controlled study was undertaken to compare the effects on heart rate and blood pressure during surgery and on the incidence of nausea, vomiting and headache after surgery of IM prochlorperazine 0.2 mg.kg-1, IV prochlorperazine 0.1 mg.kg-1 and IV ondansetron 0.06 mg.kg-1 given at induction of general anaesthesia to patients undergoing septorhinoplasty. The effects of the test drugs after administration on heart rate and blood pressure were similar, as were the incidences of retching and vomiting in the recovery ward after each test drug. Postoperatively, compar
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Tashiro, Masaki, Takafumi Naito, Yoshiyuki Kagawa, and Junichi Kawakami. "Influence of cytochrome P450 genotype on the plasma disposition of prochlorperazine metabolites and their relationships with clinical responses in cancer patients." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 55, no. 3 (2017): 385–93. http://dx.doi.org/10.1177/0004563217731432.

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Background Oral prochlorperazine, a dopamine D2 receptor antagonist, is largely metabolized to sulphoxide, 7-hydroxylate and N-desmethylate by cytochrome P450s (CYPs). This study evaluated the influence of CYP genotype on the plasma dispositions of prochlorperazine and its metabolites and their relationships with antiemetic efficacy and prolactin elevation in cancer patients. Methods Forty-eight cancer patients treated with oral prochlorperazine were enrolled. Plasma prochlorperazine and its metabolites concentrations and serum prolactin concentration were determined at 12 h after the evening
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&NA;. "Prochlorperazine see Metoclopramide/prochlorperazine." Reactions Weekly &NA;, no. 358 (1991): 11. http://dx.doi.org/10.2165/00128415-199103580-00063.

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Jagadeesh, Kadali, and Nowduri Annapurna. "Quantification of Prochlorperazine and Paracetamol Using High Performance Liquid Chromatography: Application to Tablets and Stability Studies." Asian Journal of Chemistry 31, no. 11 (2019): 2473–78. http://dx.doi.org/10.14233/ajchem.2019.22140.

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This study reports a new stability indicating HPLC method using Spursil C18 column as stationary phase, and mixture of 0.1 M Na2HPO4 and methanol (50:50 v/v) as mobile phase for the chromatographic determination of paracetamol and prochlorperazine in tablets and in bulk form. The linearity range is 250-750 μg/mL for paracetamol and 2.5-7.5 μg/mL for prochlorperazine. The limit of detection values are 2.650 μg/mL for paracetamol and 0.175 μg/mL for prochlorperazine. The minor values of the relative standard deviation (≤ 2.0 %) as well as good percent assay values (nearer to 100 %) confirm the h
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Blazheyevskiy, M. Ye, Yu V. Skrypynets, A. V. Yegorova, and V. P. Antonovich. "A New Oxidative Derivatization Method For The Indirect Spectrofluorimetric Determination Of Prochlorperazine Maleate In Pharmaceutical Preparations." Methods and Objects of Chemical Analysis 14, no. 3 (2019): 140–45. http://dx.doi.org/10.17721/moca.2019.140-145.

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A new oxidative derivatization method for the indirect spectrofluorimetric determination of Prochlorperazine maleate has been presented. Potassium hydrogenperoxomonosulphate is proposed as a derivatizing agent for Prochlorperazine, yielding the strongly fluorescent sulfoxide. This reaction product was successfully employed for the spectrofluorimetric determination of the Prochlorperazine maleate. A highly sensitive, simple and rapid method has been developed for determining prochlorperazine maleate in tablets by fluorescence of its oxidation product with Oxone solution in 0.01 M sulfuric acid
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Haverty, Charles, Julie Niedermier, and Hossam Guirgis. "120 Laryngeal Dystonia and Buccolingual Crisis: Dystonic Reactions in 2 Patients Receiving Prochlorperazine During Suboxone Therapy." CNS Spectrums 25, no. 2 (2020): 278. http://dx.doi.org/10.1017/s1092852920000383.

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Abstract:We report two cases of acute dystonia in patients after receiving prochlorperazine to address nausea in the context of buprenorphine/naloxone (Suboxone) therapy. Both were admitted for opioid withdrawal and developed nausea and vomiting refractory to ondansetron on the first hospital day.Within six hours of receiving an intramuscular injection of ten milligrams of prochlorperazine, a 24-year-old Caucasian male developed buccolingual crisis (trismus and dysphagia). His symptoms resolved with repeated intramuscular doses of diphenhydramine, benztropine, and lorazepam.A 31-year-old Cauca
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&NA;. "Prochlorperazine." Reactions Weekly &NA;, no. 1385 (2012): 37–38. http://dx.doi.org/10.2165/00128415-201213850-00136.

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&NA;. "Prochlorperazine." Reactions Weekly &NA;, no. 1368 (2011): 34. http://dx.doi.org/10.2165/00128415-201113680-00125.

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Dissertations / Theses on the topic "Prochlorperazines"

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Antunes, Edith Martins. "Stability of prochlorperazine in solution and in the solid-state." Thesis, Rhodes University, 2000. http://hdl.handle.net/10962/d1016399.

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Prochlorperazine, a member of the piperazine subclass of phenothiazines, widely used as an anti-emetic, is susceptible to oxidation to sulfoxides. These are main metabolites and degradants of all phenothiazines which are found to be inactive at the dopamine receptors. Prochlorperazine causes photosensitivity effects in patients attributed to dechlorination at C2 with the release of HCI (Huang and Sands, 1967; Nejmeh and Pilpel, 1978; Moore and Tamat, 1980). The aim of this study is to investigate the thermal and photostability of prochlorperazine edisylate and mesylate salts in the solid state
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Isah, Ambrose Ohumagho. "Clinical pharmacology of antiemetic agents : a study on prochlorperazine and metoclopramide." Thesis, University of Newcastle Upon Tyne, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308762.

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Collignon, Tanya. "Comparative bioavailability of prochlorperazine edisylate in plasma and brain tissue after intravenous, oral and intranasal administration / Tanya Collignon." Thesis, North-West University, 2003. http://hdl.handle.net/10394/404.

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The nasal administration of drugs offers advantages over administration by intravenous injection. Drugs can be rapidly absorbed through the nasal mucosa, resulting in a rapid onset of action, and also avoiding degradation in the gastro-intestinal tract and first-pass metabolism in the liver. Targeting the brain via nasal administration offers potential for the development of new drug products. The olfactory cells are in direct contact with both the environment and the central nervous system (CNS). The olfactory pathway thus circumvents the blood-brain barrier (BBB), which prevents many systemi
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Areff, Shamiel. "Metoclopramide vs Prochlorperazine for the treatment of Nausea and Vomiting in the Emergency Care Setting: A Scoping Review." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31473.

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Introduction: Nausea and vomiting are a common complaint with a wide variety of aetiologies. Patients frequently present to emergency care providers seeking treatment for nausea and vomiting. Metoclopramide and prochlorperazine are well established drugs that have long been used in the treatment of nausea and vomiting. This scoping review aims to map out the available literature on metoclopramide and prochlorperazine in treating nausea and vomiting in the emergency setting, and more specifically for prehospital use. Methods: A broad literature search was conducted using the following search te
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Hempel, Christoph. "Neue Modulatoren des P2X7-Rezeptors." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-161341.

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P2X7-Rezeptoren stellen Schlüsselmoleküle bei der Entstehung und Aufrechterhaltung proinflammatorischer Zustände, chronischer Schmerzen sowie der neuroglialen Kommunikation dar. Ihre Aktivität wird durch eine Vielzahl zellbiologischer Mechanismen beeinflusst. Dazu gehört die allosterische Modulation durch extrazelluläre niedermolekulare Stoffe. Die Entwicklung selektiver und potenter P2X7-Modulatoren ist darum Gegenstand intensiver Forschung. Bisher sind jedoch keine Pharmaka für die klinische Anwendung verfügbar. Die Untersuchung zugelassener pharmakologischer Substanzen in einem akademischen
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Sanchez, Brualla Irene. "The potassium-chloride cotransporter KCC2 : a new therapeutic target for spasticity and neuropathic pain." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0677.

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La spasticité et la douleur neuropathique sont deux symptômes apparaissant fréquemment après une lésion médullaire. La spasticité est définie comme une augmentation du tonus musculaire qui provoque des contractures, tandis que la douleur neuropathique se caractérise par des sensations douloureuses survenant suite à une lésion du système nerveux.Ces deux symptômes résultent en partie d’une désinhibition des réseaux neuronaux sous-lésionnels lié à une diminution de l’expression du cotransporteur potassium-chlorure type 2 (KCC2). Pour être efficace,l’inhibition nécessite l’action de cette protéin
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Simanjuntak, Yogy, and 史曼均. "Antiviral Discovery by Repurposing of Prochlorperazine Reveals the Role of Dopamine D2 Receptor in." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/94424458863183331986.

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博士<br>國立陽明大學<br>生化暨分子生物研究所<br>103<br>Mosquito-borne flaviviruses are an important example of emerging and resurging diseases of global significance. These RNA viruses are small, enveloped viruses that play a role as etiological agents of important human diseases including dengue fever and Japanese encephalitis. Although the mortality rate has been successfully controlled in recent years, recurrent dengue outbreak and increased prevalence have significant socio-economic impact in countries where dengue epidemic are occurring. Despite the clinical importance, no dengue virus (DENV) vaccines or a
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Lai, Chia-Jou, and 賴佳柔. "Evaluating the inhibitory effects of prochlorperazine and thiostrepton on some stem cell properties of human lung cancer." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/94913494638926321973.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>102<br>Abstract Drug resistance of chemotherapy is the major problem for non-small cell lung carcinoma (NSCLC). Connectivity map (cmap) connecting among drugs, diseases and genes allows the user to screen compounds against genome-wide disease signatures, rather than a pre-selected set of target genes. Cancer stem cell (CSC) is known to contribute to tumor relapse and drug resistance. Cmap was used to screen and predict several drugs that can reverse CSC related gene signatures. Two drugs, prochlorperazine, usually used for treating nausea, vomiting and vertigo, and t
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Hempel, Christoph. "Neue Modulatoren des P2X7-Rezeptors." Doctoral thesis, 2014. https://ul.qucosa.de/id/qucosa%3A13179.

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P2X7-Rezeptoren stellen Schlüsselmoleküle bei der Entstehung und Aufrechterhaltung proinflammatorischer Zustände, chronischer Schmerzen sowie der neuroglialen Kommunikation dar. Ihre Aktivität wird durch eine Vielzahl zellbiologischer Mechanismen beeinflusst. Dazu gehört die allosterische Modulation durch extrazelluläre niedermolekulare Stoffe. Die Entwicklung selektiver und potenter P2X7-Modulatoren ist darum Gegenstand intensiver Forschung. Bisher sind jedoch keine Pharmaka für die klinische Anwendung verfügbar. Die Untersuchung zugelassener pharmakologischer Substanzen in einem akademischen
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Books on the topic "Prochlorperazines"

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Publications, ICON Health. Prochlorperazine - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References. ICON Health Publications, 2004.

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Book chapters on the topic "Prochlorperazines"

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McAllister-Williams, R. Hamish, Daniel Bertrand, Hans Rollema, et al. "Prochlorperazine." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_1858.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of mixed valence trinuclear complex of ruthenium with prochlorperazine." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 5. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-65098-1_176.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of mixed valence trinuclear complex of rhodium with prochlorperazine." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 5. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-65098-1_271.

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Papich, Mark G. "Prochlorperazine Edisylate, Prochlorperazine Maleate." In Saunders Handbook of Veterinary Drugs. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-323-24485-5.00483-6.

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Papich, Mark G. "Prochlorperazine Edisylate, Prochlorperazine Maleate." In Papich Handbook of Veterinary Drugs. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-323-70957-6.00453-2.

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"Prochlorperazine." In Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. Elsevier, 2006. http://dx.doi.org/10.1016/b0-44-451005-2/00138-8.

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"Prochlorperazine." In Meyler's Side Effects of Drugs. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-444-53717-1.01342-1.

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"Prochlorperazine." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-36172-2_200194.

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"Prochlorperazine." In Drugs Handbook 2012–2013. Bloomsbury Academic, 2011. http://dx.doi.org/10.5040/9781350363595.art-1443.

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"Prochlorperazine." In Cambridge Prescriber's Guide in Psychiatry. Cambridge University Press, 2023. http://dx.doi.org/10.1017/9781108986335.077.

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