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Journal articles on the topic 'Prochlorperazines'

Author: Grafiati

Published: 4 June 2025

Last updated: 14 July 2025

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1

M., Mamatha 1. *. Narendra Babu 2. "SYNTHESIS OF PROCHLOROPERAZINE RELATED COMPOUND A IMPURITY FORMED DURING CHLORPROMAZINE DRUG PREPARATION." Journal of Pharma Research 8, no. 5 (2019): 311–13. https://doi.org/10.5281/zenodo.3236693.

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<strong><em>ABSTRACT</em></strong> <strong><em>I</em></strong><em>n the present work identification and synthesis of Prochlorperazine related compound A impurity in the manufacture of API Chlorpromazine has been reported. Characterization of the product was done by H1 NMR spectral data. Identification of this impurity results in synthesis of pure Prochlorperazines drugs.</em> <strong><em>KEYWORDS</em></strong><em>:  Prochlorperazines, Impurity, Sulphur, API drug.</em>

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2

Blazheyevskiy, M. Ye, and V. P. Moroz. "The Oxidative Derivatization Method For The Indirect Spectrophotometric Determination Of Prochlorperazine In Tablets." Methods and Objects of Chemical Analysis 15, no. 3 (2020): 132–36. http://dx.doi.org/10.17721/moca.2020.132-136.

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The oxidative derivatization method by means of peroxoacid for the indirect spectrophotometric determination of Prochlorperazine Maleate is presented. Potassium hydrogen peroxymonosulfate as a derivatizing agent, yielding the Prochlorperazine sulfoxide with λmaх=338 nm is proposed. This reaction product was successfully employed for the spectrophotometric determination of the Prochlorperazine Maleate. The UV spectrophotometric determination of Prochlorperazinе as its sulfoxide proved to be the more robust and selective method. Concentration dependence of the oxidation product remains linear in

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3

Van Den Berg, A. A. "The Prophylactic Antiemetic Efficacy of Prochlorperazine and Ondansetron in Nasal Septal Surgery: A Randomized Double-Blind Comparison." Anaesthesia and Intensive Care 24, no. 5 (1996): 538–45. http://dx.doi.org/10.1177/0310057x9602400505.

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A prospective, randomized placebo-controlled study was undertaken to compare the effects on heart rate and blood pressure during surgery and on the incidence of nausea, vomiting and headache after surgery of IM prochlorperazine 0.2 mg.kg-1, IV prochlorperazine 0.1 mg.kg-1 and IV ondansetron 0.06 mg.kg-1 given at induction of general anaesthesia to patients undergoing septorhinoplasty. The effects of the test drugs after administration on heart rate and blood pressure were similar, as were the incidences of retching and vomiting in the recovery ward after each test drug. Postoperatively, compar

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4

Tashiro, Masaki, Takafumi Naito, Yoshiyuki Kagawa, and Junichi Kawakami. "Influence of cytochrome P450 genotype on the plasma disposition of prochlorperazine metabolites and their relationships with clinical responses in cancer patients." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 55, no. 3 (2017): 385–93. http://dx.doi.org/10.1177/0004563217731432.

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Background Oral prochlorperazine, a dopamine D2 receptor antagonist, is largely metabolized to sulphoxide, 7-hydroxylate and N-desmethylate by cytochrome P450s (CYPs). This study evaluated the influence of CYP genotype on the plasma dispositions of prochlorperazine and its metabolites and their relationships with antiemetic efficacy and prolactin elevation in cancer patients. Methods Forty-eight cancer patients treated with oral prochlorperazine were enrolled. Plasma prochlorperazine and its metabolites concentrations and serum prolactin concentration were determined at 12 h after the evening

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5

&NA;. "Prochlorperazine see Metoclopramide/prochlorperazine." Reactions Weekly &NA;, no. 358 (1991): 11. http://dx.doi.org/10.2165/00128415-199103580-00063.

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6

Jagadeesh, Kadali, and Nowduri Annapurna. "Quantification of Prochlorperazine and Paracetamol Using High Performance Liquid Chromatography: Application to Tablets and Stability Studies." Asian Journal of Chemistry 31, no. 11 (2019): 2473–78. http://dx.doi.org/10.14233/ajchem.2019.22140.

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This study reports a new stability indicating HPLC method using Spursil C18 column as stationary phase, and mixture of 0.1 M Na2HPO4 and methanol (50:50 v/v) as mobile phase for the chromatographic determination of paracetamol and prochlorperazine in tablets and in bulk form. The linearity range is 250-750 μg/mL for paracetamol and 2.5-7.5 μg/mL for prochlorperazine. The limit of detection values are 2.650 μg/mL for paracetamol and 0.175 μg/mL for prochlorperazine. The minor values of the relative standard deviation (≤ 2.0 %) as well as good percent assay values (nearer to 100 %) confirm the h

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7

Blazheyevskiy, M. Ye, Yu V. Skrypynets, A. V. Yegorova, and V. P. Antonovich. "A New Oxidative Derivatization Method For The Indirect Spectrofluorimetric Determination Of Prochlorperazine Maleate In Pharmaceutical Preparations." Methods and Objects of Chemical Analysis 14, no. 3 (2019): 140–45. http://dx.doi.org/10.17721/moca.2019.140-145.

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A new oxidative derivatization method for the indirect spectrofluorimetric determination of Prochlorperazine maleate has been presented. Potassium hydrogenperoxomonosulphate is proposed as a derivatizing agent for Prochlorperazine, yielding the strongly fluorescent sulfoxide. This reaction product was successfully employed for the spectrofluorimetric determination of the Prochlorperazine maleate. A highly sensitive, simple and rapid method has been developed for determining prochlorperazine maleate in tablets by fluorescence of its oxidation product with Oxone solution in 0.01 M sulfuric acid

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8

Haverty, Charles, Julie Niedermier, and Hossam Guirgis. "120 Laryngeal Dystonia and Buccolingual Crisis: Dystonic Reactions in 2 Patients Receiving Prochlorperazine During Suboxone Therapy." CNS Spectrums 25, no. 2 (2020): 278. http://dx.doi.org/10.1017/s1092852920000383.

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Abstract:We report two cases of acute dystonia in patients after receiving prochlorperazine to address nausea in the context of buprenorphine/naloxone (Suboxone) therapy. Both were admitted for opioid withdrawal and developed nausea and vomiting refractory to ondansetron on the first hospital day.Within six hours of receiving an intramuscular injection of ten milligrams of prochlorperazine, a 24-year-old Caucasian male developed buccolingual crisis (trismus and dysphagia). His symptoms resolved with repeated intramuscular doses of diphenhydramine, benztropine, and lorazepam.A 31-year-old Cauca

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9

&NA;. "Prochlorperazine." Reactions Weekly &NA;, no. 1385 (2012): 37–38. http://dx.doi.org/10.2165/00128415-201213850-00136.

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&NA;. "Prochlorperazine." Reactions Weekly &NA;, no. 1368 (2011): 34. http://dx.doi.org/10.2165/00128415-201113680-00125.

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11

&NA;. "Prochlorperazine." Reactions Weekly &NA;, no. 591 (1996): 11. http://dx.doi.org/10.2165/00128415-199605910-00035.

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12

&NA;. "Prochlorperazine." Reactions Weekly &NA;, no. 667 (1997): 13. http://dx.doi.org/10.2165/00128415-199706670-00042.

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13

&NA;. "Prochlorperazine." Reactions Weekly &NA;, no. 379 (1991): 11. http://dx.doi.org/10.2165/00128415-199103790-00059.

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14

&NA;. "Prochlorperazine." Reactions Weekly &NA;, no. 303 (1990): 8. http://dx.doi.org/10.2165/00128415-199003030-00035.

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&NA;. "Prochlorperazine." Reactions Weekly &NA;, no. 342 (1991): 7. http://dx.doi.org/10.2165/00128415-199103420-00034.

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&NA;. "Prochlorperazine." Reactions Weekly &NA;, no. 350 (1991): 10–11. http://dx.doi.org/10.2165/00128415-199103500-00046.

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17

&NA;. "Prochlorperazine." Reactions Weekly &NA;, no. 942 (2003): 11. http://dx.doi.org/10.2165/00128415-200309420-00035.

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18

&NA;. "Prochlorperazine." Reactions Weekly &NA;, no. 1336 (2011): 39. http://dx.doi.org/10.2165/00128415-201113360-00125.

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19

Mule, Kishorkumar L. "RAPID ANALYTICAL METHOD FOR ASSAY DETERMINATION FOR PROCHLORPERAZINE EDISYLATE DRUG SUBSTANCES BY ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY." International Journal of Current Pharmaceutical Research 9, no. 4 (2017): 118. http://dx.doi.org/10.22159/ijcpr.2017v9i4.20973.

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Objective: To develop and validate new, simple and rapid assay method for Prochlorperazine edisylate drug substance by UPLC as per ICH guidelines.Methods: Ultra performance liquid chromatographic method was developed, optimized and validated on Acquity UPLC by using Acquity BDH300 C4 (100 x 2.1 mm) 1.7µ column. 3.85g ammonium acetate in 1000 ml of water add 0.5 ml trifluoroacetic acid and 1 ml triethylamine (Mobile phase A): 0.5 ml trifluoroacetic acid in 1000 ml acetonitrile mobile phase (Mobile phase B) with gradient program. Detector wavelength 254 nm and column temperature 30 °C.Results: L

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20

Carr, B. I., M. Bertrand, S. Browning, et al. "A comparison of the antiemetic efficacy of prochlorperazine and metoclopramide for the treatment of cisplatin-induced emesis: a prospective, randomized, double-blind study." Journal of Clinical Oncology 3, no. 8 (1985): 1127–32. http://dx.doi.org/10.1200/jco.1985.3.8.1127.

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This study compared high-dose metoclopramide and prochlorperazine for their antiemetic activities in the treatment of patients with solid tumors receiving cisplatin-based cancer chemotherapy, in a prospective, double-blind fashion. Sixty patients were entered in the study, and 28 patients on each regimen were evaluable. For regimen 1, metoclopramide was given intravenously (IV) over 15 minutes at a dose of 2 mg/kg 30 minutes before, 30 minutes after, and three hours after treatment with cisplatin. In regimen 2, prochlorperazine was given IV 30 minutes before and three hours after the cisplatin

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21

Bhagwat, G. B., S. P. Wate, and A. S. Mundhey. "DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF PROCHLORPERAZINE MALEATE AND PYRIDOXINE HYDROCHLORIDE IN TABLET DOSAGE FORM BY UV USING MULTI-COMPONENT MODE OF ANALYSIS." INDIAN DRUGS 50, no. 03 (2013): 20–25. http://dx.doi.org/10.53879/id.50.03.p0020.

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Prochlorperazine maleate and pyridoxine hydrochloride in combination are available as tablet dosage forms in the ratio of 1:5. A simple, reproducible and efficient method for the simultaneous determination of prochlorperazine maleate and pyridoxine hydrochloride in tablet dosage form has been developed. The developed method is based on the simultaneous estimation by UV Spectroscopy, using multi-component mode of analysis. In this method 0.3M HCl was used as solvent. Wavelengths selected for estimation of prochlorperazine maleate and pyridoxine hydrochloride in multi-component mode of analysis

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22

Kalashnikov, Vitaliy E., Sergey A. Tyganov, Olga V. Turtikova, et al. "Prochlorperazine Withdraws the Delayed Onset Tonic Activity of Unloaded Rat Soleus Muscle: A Pilot Study." Life 11, no. 11 (2021): 1161. http://dx.doi.org/10.3390/life11111161.

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A gradual increase in rat soleus muscle electromyographic (EMG) activity is known to occur after 3–4 days of hindlimb suspension/unloading (HS). The physiological significance and mechanisms of such activity of motoneurons under unloading conditions are currently unclear. Since hyperactivity of motoneurons and muscle spasticity after spinal cord injury are associated with KCC2 downregulation, we hypothesized that a decrease in potassium (K+)/chloride (Cl−) co-transporter 2 (KCC2) in motoneurons would be responsible for an increase in soleus muscle EMG activity during HS. We aimed to investigat

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23

Pawar, Rajat, Ravi Sharma, and Gajanan Darwhekar. "Formulation and Evaluation of Mouth Dissolving Film of Prochlorperazine Maleate." Journal of Drug Delivery and Therapeutics 9, no. 6 (2019): 110–15. http://dx.doi.org/10.22270/jddt.v9i6.3679.

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This research work was aimed to enhance the oral bioavailability and provide faster onset of action of Prochlorperazine maleate (used for the treatment nausea and vomiting) by formulating its mouth dissolving film (MDF). Prochlorperazine belongs to BCS II and oral bioavailability of it’s about 11-15%. The MDF of Prochlorperazine maleate was prepared by solvent casting method using HPMC (film forming agent),Glycerol (plasticizer), Betacyclodextrin (solubilizing agent), Citric acid (saliva stimulating agent), Mannitol (sweetening agent). The formulation was optimized by two factors, three levels

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24

Cavdar, Leyla, Solomon Ajasin, Scott Woolf, and Robert Fekete. "Abdominal Wall Dyskinesia: Case Report." Case Reports in Neurology 12, no. 1 (2020): 69–72. http://dx.doi.org/10.1159/000504336.

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The clinical presentation of repetitive choreiform involuntary movements of the anterior abdominal wall was first introduced as “belly dancer’s dyskinesia.” Etiologies of this rare condition include idiopathic causes, medication inducement, or post-abdominal surgery. We report a case of orobuccal stereotypic movements and abdominal wall dyskinesia secondary to prochlorperazine intake. The movements began 2 weeks after cessation of prochlorperazine. The patient took this dopamine receptor-blocking medication for 6 months to treat nausea due to chemotherapy. To our knowledge, abdominal wall dysk

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25

Sharma, Shailesh. "Development of Fast Dissolving Buccal Patches of Prochlorperazine Maleate for Effective Management of Emesis." YMER Digital 21, no. 08 (2022): 123–36. http://dx.doi.org/10.37896/ymer21.08/13.

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The goal of this research was to increase the oral bioavailability and avoid the first pass metabolism of Prochlorperazine Maleate (used to treat nausea and vomiting) by creating its buccal patches. Prochlorperazine is a member of BCS II and has an oral bioavailability of 11– 15%. Prochlorperazine maleate buccal patches were made by solvent casting with the aid of HPMC E-15 and Chitosan (film-forming agents), Glycerol (plasticizer), Tween 80 (penetration enhancer), Citric Acid (saliva stimulating agent), Mannitol (sweetening agent), and Ethyl Cellulose (Backing membrane). Twelve total formulat

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26

Friedman, Benjamin W., Eddie Irizarry, Clemencia Solorzano, et al. "Randomized study of IV prochlorperazine plus diphenhydramine vs IV hydromorphone for migraine." Neurology 89, no. 20 (2017): 2075–82. http://dx.doi.org/10.1212/wnl.0000000000004642.

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Objective:To determine outcomes among patients with migraine in the emergency department (ED) who receive IV hydromorphone vs IV prochlorperazine + diphenhydramine.Methods:This study was conducted in 2 EDs in New York City. Patients who met international criteria for migraine were eligible for participation if they had not used an opioid within the previous month. Clinicians, participants, investigators, and research personnel were blinded to treatment. Patients were randomized in blocks of 4. Participants received hydromorphone 1 mg or prochlorperazine 10 mg + diphenhydramine 25 mg. Diphenhyd

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27

Sultana, Sana, Shahid Mohammed, and Risha Miskan. "Innovative Nanosuspension Formulation for Prochlorperazine and In-vitro Evaluation." Journal of Drug Delivery and Therapeutics 13, no. 12 (2023): 166–76. http://dx.doi.org/10.22270/jddt.v13i12.6135.

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Prochlorperazine is a dopamine antagonist and is used to control nausea and vomiting. It is a BCS class II drug which has low aqueous solubility and high permeability. The present study is aimed to formulate and evaluate prochlorperazine nanosuspension to improve solubility and enhance dissolution of Prochlorperazine with varying concentrations of stabilizers such as Tween 80, PVP K30, Poloxamer 188 by using nanoprecipitation method. The developed formulations were characterized for particle size and polydispersity index, total drug content, SEM, Zeta Potential and FTIR. The invitro drug relea

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28

&NA;. "Imipramine/prochlorperazine." Reactions Weekly &NA;, no. 1133 (2007): 14. http://dx.doi.org/10.2165/00128415-200711330-00047.

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&NA;. "Clozapine/prochlorperazine." Reactions Weekly &NA;, no. 1354 (2011): 17. http://dx.doi.org/10.2165/00128415-201113540-00055.

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&NA;. "Metoclopramide/prochlorperazine." Reactions Weekly &NA;, no. 415 (1992): 10. http://dx.doi.org/10.2165/00128415-199204150-00050.

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&NA;. "Metoclopramide/prochlorperazine." Reactions Weekly &NA;, no. 358 (1991): 10. http://dx.doi.org/10.2165/00128415-199103580-00051.

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32

Roscoe, Joseph A., Charles E. Heckler, Gary R. Morrow, et al. "Prevention of Delayed Nausea: A University of Rochester Cancer Center Community Clinical Oncology Program Study of Patients Receiving Chemotherapy." Journal of Clinical Oncology 30, no. 27 (2012): 3389–95. http://dx.doi.org/10.1200/jco.2011.39.8123.

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Purpose We conducted a double-blind randomized clinical trial of the following four regimens for controlling delayed nausea (DN): group 1: palonosetron + dexamethasone on day 1 with prochlorperazine on days 2 and 3; group 2: granisetron + dexamethasone on day 1 with prochlorperazine on days 2 and 3; group 3: aprepitant + palonosetron + dexamethasone on day 1 with aprepitant + dexamethasone on days 2 and 3; and group 4: palonosetron + dexamethasone on day 1 with prochlorperazine + dexamethasone on days 2 and 3. Patients and Methods Chemotherapy-naive patients received doxorubicin, epirubicin, c

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33

Downton, Teesha, Emma Karlsen, Katharine Cuff, Euan Walpole, Fiona Simpson, and Elgene Lim. "Abstract OT2-10-05: HER2Pro: A Phase 1b dose de-escalation study of high dose prochlorperazine added to paclitaxel, trastuzumab and pertuzumab in patients with previously untreated HER2-positive metastatic breast cancer." Cancer Research 83, no. 5_Supplement (2023): OT2–10–05—OT2–10–05. http://dx.doi.org/10.1158/1538-7445.sabcs22-ot2-10-05.

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Abstract HER2Pro: A Phase 1b dose de-escalation study of high dose prochlorperazine added to paclitaxel, trastuzumab and pertuzumab in patients with previously untreated HER2-positive metastatic breast cancer Authors Teesha Downton1,2, Emma Karlsen1, Katharine Cuff3,4, Euan Walpole3,4, Fiona Simpson3,4, Elgene Lim1,2. Affiliations 1Garvan Institute of Medical Research, Darlinghurst NSW, Australia; 2School of Clinical Medicine, St Vincent’s Healthcare Clinical Campus, Faculty of Medicine and Health, University of New South Wales Sydney, Australia; 3Diamantina Institute, University of Queensland

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Abdul- Razzaq Mshiemish, Bahir. "Clinical Evaluation of Prochlorperazine Risk / Benefit in Emergency Department Patients Receiving I.V Tramadol." Journal of the Faculty of Medicine Baghdad 53, no. 3 (2011): 320–22. http://dx.doi.org/10.32007/jfacmedbagdad.533839.

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Background: antiemetics are commonly prescribed as prophylactic for nausea and vomiting when opiates analgesics are prescribed in the emergency department.Objective: to assess the incidence of nausea and vomiting after tramadol analgesia, and the effect of prochlorperazine on this incidence.Patients and methods: I.V tramadol was administered with prochlorperzine (group I) or pyridoxine (group II) to 44 patients with acute sever pain.Results: the incidence of nausea and vomiting was not significant between patient groups; while the occurance of extrapyramidal side effects was only seen in the p

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35

Otreba, Michal, Anna Rzepecka-Stojko, Tiago Rodrigues, Anna Kleczka, Agata Kabała-Dzik, and Jerzy Stojko. "Antioxidant Activity of Prochlorperazine Dimaleate." Acta Poloniae Pharmaceutica - Drug Research 81, no. 6 (2025): 981–92. https://doi.org/10.32383/appdr/200888.

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Reactive oxygen species participate in many physiological processes of the body, but their excess disturbs the metabolic balance and leads to an unfavorable phenomenon called oxidative stress. Several mechanisms account for ROS elimination. One of the antioxidants may be phenothiazine derivatives because of the basic chemical structure – the phenothiazine ring. The study aimed to assess the antioxidant activity of prochlorperazine dimaleate, a phenothiazine derivative, and compare it with reference antioxidants (Trolox and ascorbic acid). Thus, we investigated ABTS, DPPH, CUPRAC, FRAP, and sca

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36

Meena, Aarti, Sunita Patidar, Rajat Pawar, and P. K. Dubey. "FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLET OF PROCHLORPERAZINE MALEATE." International Journal of Pharmaceutical Sciences and Medicine 9, no. 2 (2024): 76–104. http://dx.doi.org/10.47760/ijpsm.2024.v09i02.009.

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In the present work, fast disintegrating tablets of prochlorperazine maleate were designed with a view to enhance patient compliance by effervescent method. Prochlorperazine Maleate, a potent antipsychotic medication with antiemetic properties, holds significance in treating various conditions such as nausea, vomiting, and vertigo. The decision to formulate it into orodispersible tablets aimed to address issues related to patient compliance and convenience, particularly for individuals who experience difficulty swallowing conventional tablets. Formulation F10, enriched with 10% Croscarmellose

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&NA;. "Droperidol/prochlorperazine/promethazine." Reactions Weekly &NA;, no. 1187 (2008): 13. http://dx.doi.org/10.2165/00128415-200811870-00039.

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&NA;. "Citalopram withdrawal/prochlorperazine." Reactions Weekly &NA;, no. 1157 (2007): 10. http://dx.doi.org/10.2165/00128415-200711570-00029.

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&NA;. "Fluorouracil/prochlorperazine/tretinoin." Reactions Weekly &NA;, no. 845 (2001): 9. http://dx.doi.org/10.2165/00128415-200108450-00018.

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&NA;. "Metoclopramide/prochlorperazine/trifluoperazine." Reactions Weekly &NA;, no. 1197 (2008): 31–32. http://dx.doi.org/10.2165/00128415-200811970-00105.

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Hoy, Sheridan M., and Lesley J. Scott. "Indomethacin/Prochlorperazine/Caffeine." CNS Drugs 25, no. 4 (2011): 343–58. http://dx.doi.org/10.2165/11206740-000000000-00000.

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Sharma, Adhi N., Keith Steinberg, and Lewis S. Nelson. "Akathisia and Prochlorperazine." Annals of Emergency Medicine 36, no. 2 (2000): 169–70. http://dx.doi.org/10.1067/mem.2000.108179.

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43

Weiden, P. "Akathisia from prochlorperazine." JAMA: The Journal of the American Medical Association 253, no. 5 (1985): 635c—635. http://dx.doi.org/10.1001/jama.253.5.635c.

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Weiden, Peter. "Akathisia From Prochlorperazine." JAMA: The Journal of the American Medical Association 253, no. 5 (1985): 635. http://dx.doi.org/10.1001/jama.1985.03350290037017.

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45

Maxwell, D. L., K. B. Nolop, and J. M. B. Hughes. "Effects of somatostatin, naloxone and prochlorperazine on the control of ventilation in man." Clinical Science 70, no. 6 (1986): 547–54. http://dx.doi.org/10.1042/cs0700547.

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1. In seven normal subjects the ventilatory responses to progressive isocapnic hypoxia and hyperoxic hypercapnia were measured during rebreathing. 2. During an infusion of somatostatin (10 nmol/mm) the mean hypoxic response decreased by 66% (control: − 1.6 sd 1.2 litres min−1 %−1Sao2: somatostatin: − 0.6 sd 0.7) but the mean hypercapnic response was unchanged (control: 2.0 sd 0.8 litre min−1 mmHg−1; somatostatin: 2.3 sd 1.2). There was no change in resting V˙O2 or V˙CO2 during somatostatin infusion. 3. The opiate antagonist, naloxone (0.1 mg/kg, intravenously), caused little change in either r

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Jivraj, Kabirudeen T., Thomas W. Noseworthy, Erwin G. Friesen, Allan S. Shustack, Elsie M. Konopad, and Richard G. Johnston. "Spironolactone-Induced Agranulocytosis." Drug Intelligence & Clinical Pharmacy 21, no. 12 (1987): 974–75. http://dx.doi.org/10.1177/106002808702101208.

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Agranulocytosis associated with spironolactone administration is described in a 57-year-old man. Four days after initiation of spironolactone, leukocyte counts decreased from 8.2 to 2.3 × 109/L with 6% neutrophils. Spironolactone, domperidone, and prochlorperazine were discontinued. Domperidone and prochlorperazine were reintroduced and there was concomitant improvement of the leukocyte and neutrophil counts. Substitution of triamterene for spironolactone was not associated with recurrent leukopenia. The potential association of spironolactone with granulocytopenia warrants increased awareness

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Sharlo, Kristina A., Irina D. Lvova, Sergey A. Tyganov, et al. "A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression." Current Issues in Molecular Biology 45, no. 7 (2023): 5613–30. http://dx.doi.org/10.3390/cimb45070354.

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Skeletal muscle disuse leads to pathological muscle activity as well as to slow-to-fast fiber-type transformation. Fast-type fibers are more fatigable than slow-type, so this transformation leads to a decline in muscle function. Prochlorperazine injections previously were shown to attenuate autonomous rat soleus muscle electrical activity under unloading conditions. In this study, we found that prochlorperazine blocks slow-to-fast fiber-type transformation in disused skeletal muscles of rats, possibly through affecting calcium and ROS-related signaling.

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&NA;. "Dronabinol ?? prochlorperazine has superior antiemetic efficacy to prochlorperazine in cancer patients." Inpharma Weekly &NA;, no. 768 (1990): 9. http://dx.doi.org/10.2165/00128413-199007680-00023.

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Higgins, Brenda C. "Emergency!: Prochlorperazine-Induced Dystonia." American Journal of Nursing 99, no. 11 (1999): 34. http://dx.doi.org/10.2307/3521725.

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&NA;. "Pharmacokinetics of buccal prochlorperazine." Inpharma Weekly &NA;, no. 1521 (2006): 16. http://dx.doi.org/10.2165/00128413-200615210-00034.

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