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1

Graham, Gary W., P. Charles Goebel, Randall B. Heiligmann, and Matthew S. Bumgardner. "Influence of Demographic Characteristics on Production Practices within the Ohio Maple Syrup Industry." Northern Journal of Applied Forestry 24, no. 4 (2007): 290–95. http://dx.doi.org/10.1093/njaf/24.4.290.

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Abstract Maple syrup production contributes approximately $5 million annually to Ohio's economy and provides supplemental nontimber forest product income for forestland owners. To better understand the factors that influence this important nontimber forest industry in Ohio, including producer heritage, producer age, sap collection methods, size of maple operation, and educational programming, we conducted a detailed survey of all known Ohio maple syrup producers (761 total producers). Over 80% of producers responded to the survey (620 respondents), making our analysis one of the most extensive of a maple industry in North America. In general, most maple operations in Ohio are part-time, family-based enterprises and over 25% of Ohio's maple producers are of Amish heritage. Although we estimate that there are over 400,000 taps in the state, the typical sugarbush is relatively small—the average sugarbush is 27 ac in size and over a third of the operations have fewer than 100 taps. Chi-square analyses did reveal several significant (α = 0.05) associations among producer characteristics. Although Amish producers were significantly younger and had significantly larger operations than their English or non-Amish counterparts (P < 0.001), a higher proportion of English producers reported using tubing collection systems than Amish producers (P = 0.031). Additionally, while larger maple operations tended to use tubing systems more frequently (P < 0.001), we did not detect a significant association between sap collection method (bucket versus tubing) and producer age (P = 0.169). Finally, English producers tend to be older. Older producers (>53 years old), producers using tubing collection systems, and producers with more than 250 taps were significantly more likely to participate in Ohio State University (OSU) Extension educational programming (P ≤ 0.05). These results suggest significant relationships among producer demographics and the characteristics of maple operations in Ohio, and future OSU educational programming should be tailored to reflect these important relationships.
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2

Ahuja, Vasudha, Katsuyuki Miura, Abhishek Vishnu, et al. "Significant inverse association of equol-producer status with coronary artery calcification but not dietary isoflavones in healthy Japanese men." British Journal of Nutrition 117, no. 2 (2017): 260–66. http://dx.doi.org/10.1017/s000711451600458x.

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AbstractEquol, a metabolite of the dietary isoflavone daidzein, is produced by the action of gut bacteria in some individuals who are termed as equol-producers. It is proposed to have stronger atheroprotective properties than dietary isoflavones. We examined a cross-sectional association of dietary isoflavones and equol-producer status with coronary artery calcification (CAC), a biomarker of coronary atherosclerosis, among men in Japan. A population-based sample of 272 Japanese men aged 40–49 years recruited from 2004 to 2007 was examined for serum isoflavones, serum equol, CAC and other factors. Equol-producers were classified as individuals having a serum level of equol >83 nm. The presence of CAC was defined as a coronary Ca score ≥10 Agatston units. The associations of dietary isoflavones and equol-producers with CAC were analysed using multiple logistic regression. The median of dietary isoflavones, equol and CAC were 512·7 (interquartile range (IQR) 194·1, 1170·0), 9·1 (IQR 0·10, 33·1) and 0·0 (IQR 0·0, 1·0) nm, respectively. Prevalence of CAC and equol-producers was 9·6 and 16·0 %, respectively. Dietary isoflavones were not significantly associated with CAC. After multivariable adjustment, the OR for the presence of CAC in equol-producers compared with equol non-producers was 0·10 (95 % CI 0·01, 0·90, P<0·04). Equol-producers had significantly lower CAC than equol non-producers, but there was no significant association between dietary isoflavones and CAC, suggesting that equol may be a key factor for atheroprotective properties of isoflavones in Japanese men. This finding must be confirmed in larger studies or clinical trials of equol that is now available as a dietary supplement.
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3

Jetz, Walter, Holger Kreft, Gerardo Ceballos, and Jens Mutke. "Global associations between terrestrial producer and vertebrate consumer diversity." Proceedings of the Royal Society B: Biological Sciences 276, no. 1655 (2008): 269–78. http://dx.doi.org/10.1098/rspb.2008.1005.

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In both ecology and conservation, often a strong positive association is assumed between the diversity of plants as primary producers and that of animals, specifically primary consumers. Such a relationship has been observed at small spatial scales, and a begetting of diversity by diversity is expected under various scenarios of co-evolution and co-adaptation. But positive producer–consumer richness relationships may also arise from similar associations with past opportunities for diversification or contemporary environmental conditions, or from emerging properties of plant diversity such as vegetation complexity or productivity. Here we assess whether the producer–consumer richness relationship generalizes from plot to regional scale and provide a first global test of its strength for vascular plants and endothermic vertebrates. We find strong positive richness associations, but only limited congruence of the most diverse regions. The richness of both primary and higher-level consumers increases with plant richness at similar strength and rate. Environmental conditions emerge as much stronger predictors of consumer richness, and after accounting for environmental differences little variation is explained by plant diversity. We conclude that biotic interactions and strong local associations between plants and consumers only relatively weakly scale up to broad geographical scales and to functionally diverse taxa, for which environmental constraints on richness dominate.
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Ngome Chisika, Sylvester, and Chunho Yeom. "The Key Factors Affecting Tree Producer Associations Involved in Private Commercial Forestry in Kenya." Sustainability 12, no. 10 (2020): 4013. http://dx.doi.org/10.3390/su12104013.

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Formal tree producer associations are critical for the sustainable management of private commercial farm forests in Kenya. However, there is limited information on their current status and the key factors driving their operations in the country. This paper sought to address this informational gap by reviewing the existing literature in the country from the theoretical background of sustainable development and later validating the obtained findings with the current state of knowledge at regional and global levels. Results from document content analysis indicate that there are over 10,000 tree growing farmers organized into planting groups across the country after many years of piloting by the government and private sector players. At the national level, there are two associations. These include Kenya Forest Growers Association (KEFGA), mainly composed of large scale planters, and Farm Forestry Smallholder Producers Association of Kenya (FFSPAK), targeting small-holders. Besides these two, six major sub-national associations are seeking to improve members' welfare by enhancing the acquisition of livelihood assets. Further, various socio-cultural, economic, and political factors affect their operations in Kenya. These associations have deployed multiple strategies to benefit their members. However, the formation of savings and credit cooperative societies (SACCOs) seems to be their preferred mode of community empowerment. In conclusion, even though these associations are still at the infancy stage, their future remains promising in-view of the observed behavioral change in their governance, which appears to favor entrenched equality and equity towards sustainable development.
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5

Iino, Chikara, Tadashi Shimoyama, Kaori Iino, et al. "Daidzein Intake Is Associated with Equol Producing Status through an Increase in the Intestinal Bacteria Responsible for Equol Production." Nutrients 11, no. 2 (2019): 433. http://dx.doi.org/10.3390/nu11020433.

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Equol is a metabolite of isoflavone daidzein and has an affinity to estrogen receptors. Although equol is produced by intestinal bacteria, the association between the status of equol production and the gut microbiota has not been fully investigated. The aim of this study was to compare the intestinal bacteria responsible for equol production in gut microbiota between equol producer and non-producer subjects regarding the intake of daidzein. A total of 1044 adult subjects who participated in a health survey in Hirosaki city were examined. The concentration of equol in urine was measured by high-performance liquid chromatography. The relative abundances of 8 bacterial species responsible for equol production in the gut microbiota was assessed using 16S rRNA amplification. There were 458 subjects identified as equol producers. The proportion of equol production status and the intake of daidzein increased with age. Daily intake of daidzein was larger in equol-producer. The intestinal bacteria, which convert daidzein to equol were present in both equol producers and non-producers. However, the relative abundance and the prevalence of Asaccharobacter celatus and Slackia isoflavoniconvertens were significantly higher in equol producers than those in equol non-producers. The intestinal bacteria that convert daidzein to equol are present in not only the equol producers but also in the non-producers. The daidzein intake is associated with the equol production status through an increase of A. celatus and S. isoflavoniconvertens in the gut microbiota.
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6

Noss, Erika H., Hung N. Nguyen, Sook Kyung Chang, Gerald F. M. Watts, and Michael B. Brenner. "Genetic polymorphism directs IL-6 expression in fibroblasts but not selected other cell types." Proceedings of the National Academy of Sciences 112, no. 48 (2015): 14948–53. http://dx.doi.org/10.1073/pnas.1520861112.

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Interleukin (IL)-6 blockade is an effective treatment for rheumatoid arthritis (RA), and synovial fibroblasts are a major IL-6 producer in the inflamed joint. We found that human RA and osteoarthritis (OA) synovial fibroblasts derived from independent donors reproducibly segregated into low, medium, and high IL-6 producers, independent of stimulus, cell passage, or disease state. IL-6 expression pattern correlated strongly with total mRNA expression, not mRNA stability, suggesting transcriptional rather than posttranscriptional regulation. High-fibroblast IL-6 expression was significantly associated with the IL-6 proximal promoter single nucleotide polymorphism (SNP) rs1800795 minor allele (CC) genotype. In contrast, no association between this SNP and IL-6 production was detected in CD14+ monocytes, another major producer of synovial IL-6. Luciferase expression assays confirmed that this SNP was associated with differential IL-6 expression in fibroblasts. To date, several association studies examining rs1800795 allele frequency and disease risk have reported seemingly conflicting results ranging from no association to association with either the major or minor allele across a spectrum of conditions, including cancer and autoimmune, cardiovascular, infectious, and metabolic diseases. This study points to a prominent contribution from promoter genetic variation in fibroblast IL-6 regulation, but not in other IL-6–producing cell types. We propose that some of the heterogeneity in these clinical studies likely reflects the cellular source of IL-6 in specific diseases, much of which may be produced by nonhematopoietic cells. These results highlight that functional analysis of disease-associated SNPs on gene expression and pathologic processes must consider variation in diverse cell types.
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Quarmine, William. "Predicting Ghanaian farmers’ intention to sustain the supply of quality cocoa beans." Journal of Energy and Natural Resource Management 2, no. 3 (2018): 93–98. http://dx.doi.org/10.26796/jenrm.v2i3.50.

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This article discusses the predictors of Ghanaian cocoa producers’ intention to continue adopting a recommended cocoa beanfermentation technology in the future. The analyses is carried out within the framework of the theory of planned behaviour.Three hundred and twenty-one cocoa producers were interviewed. Consistent with literature, attitudes, subjective norms andpast behaviour were significant predictors of fermentation intentions. Positive attitude relate to beliefs about ease of use oftechnologies and existence of non-financial rewards. Negative attitudes relate to lack of direct financial rewards. PurchasingClerks, Chief Farmers and society at large were found to be the salient social referents who shape producers’ fermentationintentions. Recommendations included improving implementation of current producer incentive regimes, promoting trust betweenproducers and purchasing clerks and strengthening producer association to increase the sphere of influence of the Chief Farmers.
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8

Sotimirin, Olatunji Samson. "The producer-artistic business relationship: a major concern for the survival of theatre practice in Nigeria." EJOTMAS: Ekpoma Journal of Theatre and Media Arts 7, no. 1-2 (2020): 422–32. http://dx.doi.org/10.4314/ejotmas.v7i1-2.28.

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This paper evaluates some of the perennial problems identified by scholars, writers and theatre practitioners as the bane of the growth and survival of theatre practice in Nigeria. These are inadequate funding, non-availability of befitting venues, economic and social insecurity, training and professionalism, orientation of the public sector, technological development, and so on. The central argument, however, is the issue of the business relationship between the producer and the professional theatre artiste. The paper contends that there are many issues concerning the artiste working and struggling to get paid, and artiste being exploited by producers without respectable reward. Consequently, in order to conquer these exploitative tendencies and lack of trust on the part of the producer, the paper submits that it is imperative that the artiste puts his/her professional relationship with the producer on a sound legal footing. This involves not only engaging the use of contracts constricted in agreement with good professional conventions, but also considering the need for the formation of recognized monitoring structures that will be responsible for guiding the actions and behaviour of practitioners. This ought to be done with a governmental support safeguarding the various theatre Associations and guilds as it is the case with other established Associations such as the Institute of Chartered Accountants, Society of Engineers, Nigerian Medical Association and so on. Thus, the method applied to this study is a self-report personality approach where the artistic business of the theatre is evaluated. The paper concludes that although some of the problems highlighted still exist, the situation is gradually improving, especially in terms of the availability of enough befitting venues and regularity of theatre shows at these venues.
 Keywords: Artistic, Nigeria, Theatre practitioners, Producer-artistic business relationship
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9

Parker Gaddis, K. L., J. H. Megonigal, J. S. Clay, and C. W. Wolfe. "Genome-wide association study for ketosis in US Jerseys using producer-recorded data." Journal of Dairy Science 101, no. 1 (2018): 413–24. http://dx.doi.org/10.3168/jds.2017-13383.

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10

Dainese, Matteo, Nick J. B. Isaac, Gary D. Powney, et al. "Landscape simplification weakens the association between terrestrial producer and consumer diversity in Europe." Global Change Biology 23, no. 8 (2017): 3040–51. http://dx.doi.org/10.1111/gcb.13601.

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11

Purwaningsih, Endang, Nurul Huda, and Nelly Ulfah A.R. "PRODUCT CERTIFICATION AND LEGAL PROTECTION TO ENHANCE INDONESIAN TRADITIONAL HERBAL PRODUCTIONS." Mimbar Hukum - Fakultas Hukum Universitas Gadjah Mada 27, no. 3 (2016): 566. http://dx.doi.org/10.22146/jmh.15885.

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This study is aimed to empower traditional herbs producer and help legal protection of Indonesian traditional medicines, implementing Participatory Research and juridical-sociological approaches. Data
 were collected through literary, questionnaire, interview and Focus Group Discussion. The first year study revealed that Herbal Producer Association worked with all members, persuading government offices to get product certification and effective trademark licenses. In the second year study the researchers and Producers Association trained and facilitated vendors to endorse trademark, label registry, and markets shares. Producers maintain traditional medicine management, because product certification is hard to achieve.
 
 
 Penelitian ini bertujuan untuk memberdayakan produsen jamu/OT dan membantu perlindungan hukumnya, dengan memanfaatkan pendekatan penelitian partisipatoris dan sosiologis yuridis. Data dikumpulkan dengan literatur, kuesioner, wawancara dan Focus Group Discussion (FGD). Pada tahun pertama organisasi gabungan pengusaha jamu (GP Jamu) bersama-sama dengan seluruh anggotanya mendorong pemerintah untuk perolehan sertifikasi produk izin edar dan merek secara efektif. Pada tahun kedua, peneliti dan gabungan pengusaha jamu melakukan pelatihan guna perolehan izin edar, pendaftaran merek, dan peningkatan pemasaran. Para pengusaha jamu tradisional perlu terus menerus didampingi karena perolehan izin edar terkesan sulit.
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12

Reis Lima, Maria João, Luisa Fontes, Hamdi Bahri, Ana C. A. Veloso, Edite Teixeira-Lemos, and António M. Peres. "Fatty acids profile of Serra da Estrela PDO cheeses and respective atherogenic and thrombogenic indices." Nutrition & Food Science 50, no. 3 (2019): 417–32. http://dx.doi.org/10.1108/nfs-06-2019-0178.

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Purpose This study aims to determine the physicochemical and fatty acids composition of Serra da Estrela cheese (SEC), as well as health-related lipid indices, like the atherogenic and thrombogenic indices, and to evaluate the influence of producer, geographical origin and production date. Design/methodology/approach All 24 SEC produced between November 2017 and March 2018 were collected at selected certified producers and analyzed by NIR spectrophotometer and by GC. Data were statistically evaluated by chemometric tools. Findings In all evaluated SEC, 23 fatty acids were quantified. Cheese origin influenced nutritional and health-related lipid indices). The cheeses were characterized by a relative high abundance of saturated fatty acids (67-76%), followed by a medium content of monounsaturated fatty acids (17-25%) and by low level of polyunsaturated fatty acids (5-7%). A putative positive association between cheese consumption and healthy lipid indices could be reached. Practical implications The contents of some medium and long chain fatty acids as well as of nutritional and health indices were influenced by cheese producer, geographical origin and production date pointing out the need for standardizing production procedures. Social implications The SEC plays a key role in the local economy, being an endogenous product with unique sensory characteristics and nutritional potential, for which the knowledge of the lipids profile and health indices is of utmost relevance. Originality/value SEC is an iconic Portuguese cheese with Protected Designation of Origin. Based on the results, like health-related lipid indices, evaluated for the first time, a positive association between cheese consumption and healthy lipid indices could be envisaged.
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Mohd Zahir, Nur Syarafina, Nabilah Huda Abdul Halim, and Hanani Ahmad Yusof. "Association of Oral Microbiota Properties on Hyaluronidase and Biofilm Formation." ASM Science Journal 15 (May 17, 2021): 1–7. http://dx.doi.org/10.32802/asmscj.2020.474.

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Correlation between hyaluronidase (Hyl) activity and biofilm detachment in a few bacterial species was found. However, it is unclear if this association applies to bacterial species or for more general bacterial characteristics. This study determined the association between biofilm production and Hyl activity among bacterial isolates from the oral cavity of healthy subjects, and its association with Gram staining group, colony surface morphology and bacteria shape. The swab was taken from the tongue, cheek and entire teeth surfaces of 35 subjects, and tested for biofilm through modified microtiter plate assay while Hyl production was screened through HA rapid plate method. Forty-four isolates were found, each 50% are Gram-positive, and Gram-negative bacteria, with the majority are cocci and non-mucoid colony. More than 70% of isolates are moderate and strong; (n= 17, 38.6%) and (n=15, 34.1%) respectively for biofilm production; and 68.2% are Hyl producer. A significant association was found between Hyl and bacterial shape (p=0.018) and colony morphology (p=0.018), while other association is not significantly measured, including between Hyl and biofilm (p=0.659). This study showed that biofilm production is not affected by the characteristics of the bacteria to produce or not produce hyaluronidase. Meanwhile, Hyl production is prone in rod shape and mucoid isolates which need further investigations.
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Adijaya, Abraham. "PENGARUH BRAND EQUITY TERHADAP KEPUTUSAN PEMBELIAN SMARTPHONE SAMSUNG OLEH MAHASISWA UNIVERSITAS X." Jurnal Ilmiah Bisnis dan Ekonomi Asia 10, no. 1 (2016): 1–5. http://dx.doi.org/10.32812/jibeka.v10i1.79.

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Currently existing business competition is not only limited to the quality of products, technology products, and display products, but also about the brand used in the product that can cause an image to consumers. Brand is the label that carries meaning and associations as well as a mirror of promise communicated by the producer to the consumer on the quality of products or services that have been produced. This study aims to determine whether the brand awareness, brand association, perceived quality, brand loyalty and other proprietary brand assets Samsung has a positive contribution to brand equity Samsung, knowing which variable dominant contributes positively to brand equity Samsung, and find out whether brand equity Samsung influence the purchasing decisions of Samsung smartphone products. By using principal component analysis and simple linear regression analysis, the result is Samsung’s brand awareness, brand association, perceived quality, brand loyalty, and other proprietary brand assets are able to contribute positively to the Samsung brand equity. Samsung's brand loyalty is the dominant variable that contributes positively to the Samsung brand equity. Samsung's brand equity have positive significant influence on purchasing decisions Samsung smartphone products.
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Lunardi, Lígia Uno, Roberta Losi Guembarovski, Luiz Ricardo Hanai, et al. "Identification of a splicing coactivator gene that affects the production of ochratoxin a in Aspergillus carbonarius." Brazilian Archives of Biology and Technology 52, spe (2009): 131–41. http://dx.doi.org/10.1590/s1516-89132009000700018.

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Ochratoxin A is a mycotoxin produced by some fungi species. Among them, Aspergillus carbonarius is considered a powerful producer. Genes involved in the ochratoxin A biosynthesis pathway have been identified in some producer species. However, there are few studies that purpose to identify these genes in A. carbonarius. The use of insertion mutants to identify genes associated with certain properties has been increased in the literature. In this work, the region of T-DNA integration was investigated in one A. carbonarius ochratoxin-defective mutant previously obtained by Agrobacterium tumefaciens-mediated transformation, in order to find an association between interrupted gene and the biosynthesis of ochratoxin A. The integration occurred in a gene that possibly encodes a splicing coactivator protein. The analysis of the relative expression of the splicing coativator gene from A. carbonarius wild type strain in four different media showed high correlation between the transcript levels and the ochratoxin A production.
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Kearns, Ade. "Affordability for Housing Association Tenants. A Key Issue for British Social Housing Policy." Journal of Social Policy 21, no. 4 (1992): 525–49. http://dx.doi.org/10.1017/s004727940002016x.

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ABSTRACTAs a result of changes to the financial regime for housing associations, affordability has become a major issue of debate in social rented housing in Britain. This paper assesses the implications of trying to construct a finance system for housing associations based on a regime of ‘affordable rents’ and the ‘safety net’ of Housing Benefits but with the state declining to define the central concept of affordability. Using examples of a number of Western countries, and empirical evidence from the sector in Scotland, the present position is criticised, and a route out of the policy vacuum is suggested. This is founded on the premise that housing is a means rather than an end, within a broader social policy. Given the political constraints, one solution lies in studies of the expenditure patterns and standards of living of different groups of housing association tenants, and in the creation of a sector-specific organisational subsidy to be available in addition to the usual producer- and consumer-subsidies.
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17

Abdul Halim, Nabila Huda, Nur Syarafina Mohd Zahir, Nor Munirah Mohd Amin, and Hanani Ahmad Yusof @ Hanafi. "Distribution of Hyaluronidase-producing Staphylococcus aureus and Staphylococcus epidermidis Isolated from Palm Skin and Anterior Nares of Healthy Malaysian Adults." Journal of Clinical and Health Sciences 5, no. 1 (2020): 42. http://dx.doi.org/10.24191/jchs.v5i1.9820.

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Introduction: The distribution of Staphylococcus aureus and Staphylococcus epidermidis among Malaysian healthy adults and their capability to produce enzyme hyaluronidase are less reported. Hyaluronidase degrade hyaluronic acid in animal connective tissue and facilitate bacterial spreading in host body. This study aims to identify the distribution of both Staphylococci species in healthy subject, the hyaluronidase producer among the isolates and the association of the latter with site of isolation (palm skin and anterior nares) and gender ofthe host. Methods: A total of 108 swab samples were collected from anterior nares and palm of 54 healthy subjects. The bacteria were identified through microscopic and biochemical tests, before screened for hyaluronidase production using hyaluronic acid diffusion rapid plate method. Results: Total of 139 bacterial isolates were identified; 68 isolates are S. aureus, 63 S. epidermidis and 8 other bacterial species. Staphylococcus aureus was highly isolated from palm (57%) than anterior nares (47%). On the contrary for S. epidermidis was highly isolated from anterior nares (53%) than from palm skin (43%). Equal proportion was found for both species in male and female subject. A total of 77 (59%) isolates produced hyaluronidase; 55%are S. aureus and 45% are S. epidermidis. Hyaluronidase-producer isolates are equally found between anterior nares (56%) and palm skin (61%) or male (57%) and female subject (60%) regardless of Staphylococcal species. No significant value was recorded for any analysis. Conclusion: Capability of commensal S. aureus and S. epidermidis isolated from healthy subject to produce hyaluronidase may indicate their potential as opportunistic pathogen whenever the opportunity arises in any way.
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Cuteri, Vincenzo, Anna Rita Attili, Matteo Cerquetell, Fabrizio Pampurini, Fulvio Laus, and Andrea Spaterna. "Association Between Enrofloxacin and N-Acetylcysteine in Recurrent Bronchopneumopathies in Dogs Caused by Biofilm Producer Bacteria." Journal of Animal and Veterinary Advances 11, no. 4 (2012): 462–69. http://dx.doi.org/10.3923/javaa.2012.462.469.

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Shridhar, Sridevi, and Biranthabail Dhanashree. "Antibiotic Susceptibility Pattern and Biofilm Formation in Clinical Isolates of Enterococcus spp." Interdisciplinary Perspectives on Infectious Diseases 2019 (March 3, 2019): 1–6. http://dx.doi.org/10.1155/2019/7854968.

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Enterococcus is a commensal in the intestine and is now emerging as a drug-resistant pathogen. It produces different virulence factors. Enterococcus surface protein (esp) is a virulence factor that helps in the adhesion, but its role in biofilm formation is still contradictory. Moreover, in many bacterial species, strong biofilm producer exhibits multidrug resistance. Hence, this study is done to know the antimicrobial susceptibility pattern of Enterococcus spp. and to correlate the drug resistance with biofilm production and esp gene. Enterococcal isolates were collected from various clinical specimens. Antibiotic susceptibility testing was done by disc diffusion, and biofilm production was performed by microtiter plate method. PCR was performed for detection of esp gene. Two E. faecium strains resistant to vancomycin and high-level aminoglycoside (HLAR) were non-biofilm-producers and did not harbor esp gene. However, other biofilm-producing E. faecium harbored esp gene, and this association was found to be statistically significant (p=0.024). It was observed that there was no significant association between biofilm formation and presence of esp gene in E. faecalis. Moreover, a significant correlation was not found between drug resistance and biofilm production in both Enterococcus species. Thus, biofilm formation is not always associated with the presence or absence of esp gene and or drug resistance in Enterococcus spp.
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Cinar, Derya. "Science Student Teachers’ Cognitive Structure on the Concept of “Food Pyramid”." International Education Studies 9, no. 7 (2016): 21. http://dx.doi.org/10.5539/ies.v9n7p21.

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<p class="apa">The current study aims to determine science student teachers’ cognitive structure on the concept of food pyramid. Qualitative research method was applied in this study. Fallacies detected in the pre-service teachers’ conceptual structures are believed to result in students’ developing misconceptions in their future classes and will adversely affect their future teaching performance. The data were collected from 48 science student teachers. A free word association test was used as a data collection instrument. The data collected were subject to content analysis. Analyzing the science student teachers’ responses to the concept of food pyramid on the free word association test, these responses were coded and divided into categories. Based on the categories, frequency and percentages were provided. The data collected through the study were divided into 7 categories, which were stated as follows: -relationship between producer, consumer and decomposer in matter and energy flow-concepts related to nourishment pyramid-definition of food pyramid-energy and matter transfer-producer, consumer and decomposer-elements of ecosystem and ecological factors- scientific disciplines related to food pyramid. When the words provided as answers by the science student teachers to the concept of food pyramid were analyzed, it was noticed that they had more word connections with relationship between producer, consumer and decomposer in matter and energy flow. It can be argued that some students could not produce any sentences and some others could not make meaningful sentences. Moreover, it was determined that they had some misconceptions about food pyramid. Similar research can be conducted with different student groups and for the correction of alternative concepts related to the concept of food pyramid, extra biology courses should be included in undergraduate curriculums.</p>
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Derkach, S. М., V. V. Volkohon, and V. P. Horban. "EXOGENOUS PHYSIOLOGICALLY ACTIVE SUBSTANCES OF TRICHODERMA HARZIANUM 128 AND THEIR SYNTHESIS WHILE INTRODUCTION OF MICROMYCETES INTO COMPOSTED SUBSTRATE." Agriciltural microbiology 29 (October 17, 2019): 37–45. http://dx.doi.org/10.35868/1997-3004.29.37-45.

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Objective. To study the possibility of production of physiologically active substances by the as-sociation of micromycetes Trichoderma harzianum 128, which is used for enrichment composted substrates based on chicken litter. Methods. Microbiological, physiological, accumulative thin lay-er chromatography, high-performance liquid chromatography (HPLC / MS). Results. T. harzianum 128 produces a significant amount of physiologically active growth stimulanting substances. Soak-ing of corn seeds in the culture liquid of micromycetes association, diluted with water in 100– 10,000 times, provides a reliable growth stimulation of seedlings and indicates the absence of phy-totoxicity in microorganisms. The instrumental determination of the content of exogenous phyto-hormones in pre-purified and concentrated phytohormonal extracts shows a significant amount of auxins in a culture fluid — their total amount reaches 18.33 μg/g of dry biomass of the producer, and of cytokinins, in particular, isopentenylidenidine (5.6 μg/g of dry biomass) and zeatin (0.88 μg/g dry biomass). Association T. harzianum 128 in small quantities produces gibberellic acids — GK3 (0.34 μg/g dry biomass) and GK4 — 0.23 μg/g of dry biomass). Absorbent acid was also found in the culture fluid (5.3 μg/g dry biomass), but its amount is four times less than the cor-responding measures in the known strain T. viride F100001, which was used as a positive control in the studies. While the introduction of association T. harzianum 128 into the composted chicken litter substrate, the obtained compost shows high auxin and cytokinin activity. Conclusion. Phyto-hormones, which are produced by the micromycetes association of T. harzianum 128, can positively influence the growth and development of plants, play a protective role in adverse environmental conditions. After introduction of the investigated fungi association to a composted substrate on the basis of chicken litter it accumulates significant amounts of physiologically active substances of auxin and cytokinin action. Under these conditions compost acquires new qualitative features.
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Parral Quintero, Luis Enrique. "LAS ORGANIZACIONES DE PRODUCTORES DE CAÑA Y SUS RELACIONES DE PODER. EL CASO DE LA ASOCIACIÓN LOCAL DE CAÑEROS DE CASASANO, EN CUAUTLA DE MORELOS, MÉXICO." Revista Pueblos y fronteras digital 9, no. 18 (2014): 81. http://dx.doi.org/10.22201/cimsur.18704115e.2014.18.24.

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El cultivo de caña de azúcar forma parte de una tradición agrícola establecida en la época colonial. Es ese tiempo la hacienda se encargaba de organizar su producción. Esto ha ido cambiando. Con el movimiento revolucionario se resquebrajó la estructura hacendaria y surgieron nuevos actores en el campo, llamados ejidatarios. Al mismo tiempo se establecieron decretos encaminados a proteger los complejos industriales para que los ejidatarios aledaños al ingenio continuaran con su producción. Ante este panorama es importante analizar la forma en la que los productores se han ido articulando y las relaciones de poder que se generan en este proceso mediante la intervención de las asociaciones locales de productores.
 SUGARCANE PRODUCER ORGANIZATIONS AND THEIR POWER RELATIONS: THE CASE OF THE CASASANO LOCAL SUGARCANE FARMERS ASSOCIATION IN CUAUTLA DE MORELOS, MEXICO 
 Sugarcane cultivation is part of an agricultural tradition established during the colonial period. During that time, sugarcane production was organized by large land holdings known as haciendas. This has changed. With the revolutionary movement, this landed estate structure crumbled and rural areas experienced the emergence of new communal landholders, known as ejidatarios. At the same time, laws aimed at protecting industrial complexes were decreed enabling the communal landholders adjacent to sugar refineries to continue with production. Within this scenario, it is important to analyze the way in which producers have been articulating as well as the power relationships generated through this process via the intervention of local producer associations.
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Padilla, Washington, Jesús García, and José Molina. "Knowledge Extraction and Improved Data Fusion for Sales Prediction in Local Agricultural Markets." Sensors 19, no. 2 (2019): 286. http://dx.doi.org/10.3390/s19020286.

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In this paper, a monitoring system of agricultural production is modeled as a Data Fusion System (data from local fairs and meteorological data). The proposal considers the particular information of sales in agricultural markets for knowledge extraction about the associations among them. This association knowledge is employed to improve predictions of sales using a spatial prediction technique, as shown with data collected from local markets of the Andean region of Ecuador. The commercial activity in these markets uses Alternative Marketing Circuits (CIALCO). This market platform establishes a direct relationship between producer and consumer prices and promotes direct commercial interaction among family groups. The problem is presented first as a general fusion problem with a network of spatially distributed heterogeneous data sources, and is then applied to the prediction of products sales based on association rules mined in available sales data. First, transactional data is used as the base to extract the best association rules between products sold in different local markets, knowledge that allows the system to gain a significant improvement in prediction accuracy in the spatial region considered.
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Florea, Andrei-Mirel, Alexandru Capatina, Riana Radu, et al. "Limiting Factors that Influence the Formation of Producer Groups in the South-East Region of Romania: A Fuzzy Set Qualitative Comparative Analysis (fsQCA)." Sustainability 11, no. 6 (2019): 1614. http://dx.doi.org/10.3390/su11061614.

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The fragmentation of the Agricultural Real Estate in Romania, which is due to the lack of vision regarding the retrocession of the land and to the ineffective measures for reparcelling farmland, manifests by the existence of a record number of about 3422 million farms in Romania, of which about 92% have a utilized agricultural area (UAA) below 5 ha. The Romanian agricultural sector possesses about 30% of the total European farms but contributes only 3% to the total EU agricultural production. The association of local agricultural producers may be an alternative to reparcelling farmland on a short-term basis in order to reduce the fragmentation degree and increase the competitiveness of the national agricultural sector. According to the statistics of the Ministry of Agriculture and Rural Development, 25 active groups of agricultural producers are registered in the South-East Region in 2018, where these associative entities have been recorded to have a low degree of viability. The paper proposes an analysis on the farmers’ motivation regarding the access to/exit from a form of agricultural association and the identification of some alternatives for increasing the viability of the associative forms in the agricultural sector in the South-East of Romania. In this respect, a study was carried out on a sample of 16 entities that gave up their status of producer groups in the analyzed region in 2011–2018. The Fuzzy Set Quantitative Comparative Analysis (fsQCA) Qualitative analysis method was applied, which identified the main influence factors that have led to the disappearance of this associative form. We consider this study relevant for drawing attention to the main obstacles that Romanian farmers face in joining an associative form. The study has shown that mainly the factors directly influenced by government policies have led to the withdrawal of a relatively large number of producers from producer groups in the studied region.
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Santana-Davila, Rafael, John Crowley, Brian Durie, Bart Barlogie, Philip Greipp, and Brian Van Ness. "Genetic Polymorphisms Associated with Clinical Outcome in the Intergroup Trial S9321, Comparing High Dose Therapy with Standard Dose Therapy for Myelomaon, on Behalf of ECOG, SWOG, CALGB, and the Bank on a Cure." Blood 104, no. 11 (2004): 1495. http://dx.doi.org/10.1182/blood.v104.11.1495.1495.

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Abstract Genetic variations in patient populations likely contribute to disease progression and therapeutic outcomes. We have begun a systematic approach to examine the association of genetic variations (ie. functional, single nucleotide polymorhisms, SNPs) involved in myeloma growth promotion, metabolic events, drug responses, and DNA repair on clinical outcome in the intergroup trial S9321. This trial tested a single high dose regimen with autologous stem cell support against a conventional dose regimen, with further randomization of responders to maintenance with interferon or not, in newly diagnosed patients with multiple myeloma. ECOG, CALGB and SWOG enrolled 899 patients with newly diagnosed MM to receive VAD induction x 4 cycles followed by randomization to PBSC-supported high dose therapy (HDT) versus standard dose therapy (SDT) of VBMCP, using CTX 4.5 g/m2 + G-CSF for PBSC mobilization in all patients. Responders to VBMCP or HDT were randomized to IFN or no maintenance. Specimens were distributed through ECOG for biologic correlative studies, including candidate SNP analysis. SNP assays have been developed using the Sequenom Mass-extend platform for functional SNPs in IL-6, IL-1, IL-RA, IL-10, TNF, Lta, TGFb, MDR1, MPO, CYP3A4, GST (M, P, T), ERCC2 and XRCC1, and are being evaluated on 803 DNA samples prepared from patients enrolled in S9321. Preliminary findings (n=135) demonstrate functional genetic variants of IL-10 (position -1082), IL-1 (position +3953), TGFb (postion -509), and TNFa (position -308) are showing trends associated with differences in progression free survival; and variants in IL-6 (position -174) are associated with response. Median survival of the IL-10 variants was 31 months for A/A low producer alleles versus 19 months for the G/G high producer alleles (p=.5). For TNFa, 2 cases with the high producer A/A alleles died within a year, while the median survival for the lower producer G/G alleles was 2 years (p=.04). For patients with the high producer C/C/ allele of IL-1 (n=67), median survival was 2 years, versus 5 patients with the T/T low producer alleles that had a median survival greater than 5 years (preliminary p=.29). While these preliminary results are now only suggestive of trends in genetic polymorphisms associated with clinical outcome, completion of the full SNP panel on the entire sample base should provide a extensive association study, and analysis of potential differences in therapy arms of the trial. The full panel and association studies will be presented.ααββααα
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Song, Yue, Jean Ruf, Philippe Lothaire, et al. "Association of Duoxes with Thyroid Peroxidase and Its Regulation in Thyrocytes." Journal of Clinical Endocrinology & Metabolism 95, no. 1 (2010): 375–82. http://dx.doi.org/10.1210/jc.2009-1727.

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Abstract Context: Thyroid hormone synthesis requires H2O2 produced by dual oxidases (Duoxes) and thyroperoxidase (TPO). Defects in this system lead to congenital hypothyroidism. H2O2 damage to the thyrocytes may be a cause of cancer. Objective: The objective of the study was to investigate whether Duox and TPO, the H2O2 producer and consumer, might constitute a complex in the plasma membrane of human thyroid cells, thus maximizing efficiency and minimizing leakage and damage. Design: The interaction between Duox and TPO was studied by coimmunoprecipitation and Western blotting of plasma membranes from incubated follicles prepared from freshly resected human thyroid tissue from patients undergoing thyroidectomy, and COS-7 cells transiently transfected with the entire Duoxes or truncated [amino (NH2) or carboxyl (COOH) terminal]. Results: The following results were reached: 1) Duox and TPO from membranes are coprecipitated, 2) this association is up-regulated through the Gq-phospholipase C-Ca2+-protein kinase C pathway and down-regulated through the Gs-cAMP-protein kinase A pathway, 3) H2O2 increases the association of Duox1 and Duox2 to TPO in cells and in membranes, and 4) truncated NH2- or COOH-terminal Duox1 and Duox2 proteins show different binding abilities with TPO. Conclusion: Coimmunoprecipitations show that Duox and TPO locate closely in the plasma membranes of human thyrocytes, and this association can be modulated by H2O2, optimizing working efficiency and minimizing H2O2 spillage. This association could represent one part of a postulated pluriprotein complex involved in iodination. This suggests that defects in this association could impair thyroid hormone synthesis and lead to thyroid insufficiency and cell damage.
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Candido, Matheus Joaquim dos Santos, Surama Freitas Zanini, Marcus de Freitas Ferreira, et al. "Main causes of chicken carcass condemnations in Espírito Santo, Brazil." Semina: Ciências Agrárias 42, no. 3 (2021): 1129–46. http://dx.doi.org/10.5433/1679-0359.2021v42n3p1129.

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Brazil is the third largest producer and the main exporter of chicken meat in the world. In 2019, it produced approximately 13.245 million tons of the product, generating more than six million dollars. According to the Poultry Association of the state of Espírito Santo, broiler production is carried out by 28 independent producers/companies, three integrator businesses, 42 integrated producers and seven slaughterhouses (structures with SIF, SIE/SISBI or SIE certification). Despite the growth of this sector, problems persist regarding the quality of carcasses and the number of condemnations. From the sanitary and industrial point of view, all products of animal origin must undergo prior inspection. The present study was developed using data generated by the Federal Inspection Service (Serviço de Inspeção Federal, SIF) and the State Inspection Service (Serviço de Inspeção Estadual, SIE). The main causes of condemnation of birds as inspected by SIF represented 9.26% of the slaughtered birds. Total condemnations corresponded to 1.35%. Overall, this study recorded a greater number of condemnations of non-pathological origin. In conclusion, there was consistency in the reasons why these products were condemned. Bruises/fractures and contamination were the most frequent causes according to both inspection services (SIF and SIE), indicating a common problem on the slaughter and inspection lines.
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Zhang, Yinbing. "Research on Health Effects of Environmental Chemicals Based on Structure and Gene Association Analysis." Materials Physics and Chemistry 1, no. 4 (2019): 1. http://dx.doi.org/10.18282/mpc.v1i4.791.

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<p>China is a major producer and consumer of chemicals. The production and use of chemicals play a role in the development of the entire national economy. Therefore, effective chemical management has a huge impact on the development of the national economy. At present, chemical management guidelines have achieved a lot in chemical operations, but there are still many shortcomings. Relevant institutions should further improve the standard system, strengthen the coordination of subjective institutions, the supervision and management, establish information standards, complete information sharing, build a feedback system, strengthen the transformation of experimental results and trust training.</p>
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SUNNY, FRANSISCA, TRI HANDAYANI KURNIATI, and ARIANI HATMANTI. "ISOLASI DAN KARAKTERISASI BAKTERI PENGHASIL SENYAWA ANTIBAKTERI YANG BERASOSIASI DENGAN KARANG BATU DARI PERAIRAN BITUNG DAN SPONS DARI SELAT MAKASSAR." BIOMA 11, no. 1 (2015): 42. http://dx.doi.org/10.21009/bioma11(1).5.

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ABSTRACT
 Recently the needs of antibacterial compounds is increasing. This is due to the bacterial resistence to common antibacterial compounds. coral and sponge-ssociated bacteria are potential producer of antibacterial compounds. This research was aim to obtain coral and sponge-associated bacteria that could produce antibacterial compound. coral associated-bacteria was isolated from Bitung and was isolated in Marine Agar by pour plate method. The antibacterial compounds were obtained by extraction using ethyl acetate and acetone. The antibacterial assay was performed by agar diffusion method using paper discs and was performed by testing with Staphylococcus aureus, Bacillus subtilis, Vibrio cholerae biotipe El Tor, and Escherichia coli. Total 37 isolate was isolated from corals and 25 isolate from sponge obtained from Selat Makassar. Based on the assay, only bacteria from sponge that showed antibacterial activity. Two sponge-associated bacteria, S.5-8 and S.2-1 NRBC were found to inhibit S. aureus. From those isolates, isolate S.5-8 produced bigger clear zone (2,6 mm) than S.2-1 NRBC (1,5mm). S.5-8 could hydrolize gelatine whereas S.2-1 NRBC showed positive result on oxidase test and was able to fement xilose and arabinose to produce acid.
 
 Key words: antibacterial activity, association, characterization, coral, isolation, sponge
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Wiegering, Verena, Julia Taschik, Imme Haubitz, Matthias Eyrich, Beate Winkler та Paul Gerhardt Schlegel. "TGFβ and IL10 Have an Impact on Risk Group and Prognosis in Childhood ALL". Blood 124, № 21 (2014): 5337. http://dx.doi.org/10.1182/blood.v124.21.5337.5337.

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Abstract Introduction: Considering that cytokines play an important role in immune response and that many infectious, autoimmune and malignant diseases are influenced by cytokine production, we hypothesized that genetically determined cytokine gene polymorphism might have an important influence on prognosis in pediatrics acute lymphoblastic leukemia (ALL). Methods: In this study, 95 pediatric ALL-patients were examined with regard to cytokine gene polymorphisms (TNFα, TGFβ, IL10 and IFNγ) and their potential association with prognosis. Moreover we analyzed the intracellular production of theses cytokines in patient T-cells. Results: TGFβ high-producer-haplotypes were associated with high-risk ALL-patients (Codon 10: T/T) and with the tendency of a reduced overall survival, whereas IL10 high-producer-genotypes were associated with a reduced relapse rate and a superior overall survival compared to IL-10-low-producer patients. Gene-polymorphisms of the pro-inflammatory cytokines IFNγ and TNFα did not show an impact on prognosis and risk-group of ALL in our cohort. On a functional basis TNFα and IFNγ expression of T-cells at initial diagnosis was significantly reduced in high-risk- and T-ALL-patients in comparison to healthy controls. Summary: Cytokine gene-polymorphisms of the regulatory/anti-inflammatory cytokines TGFβ and IL10, but not of the pro-inflammatory cytokines IFNγ and TNFα seem to have an impact on prognosis of pediatric ALL patients. Reduced capacity to produce pro-inflammatory cytokines at diagnosis may serve as a functional risk factor. These data may help in further risk stratification and adaptation of therapy-intensity. Disclosures No relevant conflicts of interest to declare.
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Valros, Anna, and Claire Barber. "Producer Perceptions of the Prevention of Tail Biting on UK Farms: Association to Bedding Use and Tail Removal Proportion." Animals 9, no. 9 (2019): 628. http://dx.doi.org/10.3390/ani9090628.

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Tail biting causes widespread problems both for animal welfare and in the form of economic losses in pig production. This study was performed to better understand the perceptions of farmers on how to best prevent tail biting, and if perceptions are influenced by the specific system of farming, with a focus on different levels of bedding use and docking different proportions of the tail of their pigs. Pig producers in the UK were surveyed on their perceptions of the efficacy of preventive measures and attitudes towards tail biting and docking. In total, 204 responses were included. The results show that producers rank the importance of preventive measures differently to scientists and other experts. This calls for consideration when communicating with producers; and for better integration of knowledge based on practical experiences with scientific results. The study also shows that the perception of how to best avoid tail biting differs between farms of different types, and that these perceptions might be influenced by the farmers´ own experiences—one example being that farms currently using plentiful amounts of bedding also value this more highly as a way to avoid tail biting than those that do not.
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Van Ness, Brian G., John C. Crowley, Christine Ramos, et al. "SNP Genotypes Show Association with Common Toxicities during both VAD Induction and High Dose Melphalan with Autologous Transplant Support in Intergroup Trial S9321 for Myeloma: From the Bank on a Cure." Blood 106, no. 11 (2005): 3488. http://dx.doi.org/10.1182/blood.v106.11.3488.3488.

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Abstract Patients with multiple myeloma show significant heterogeneity with respect to progression, therapeutic response and toxicities. Part of the Bank On A Cure project is to examine potential genetic polymorphisms that may be associated with common toxicities monitored in clinical trials. The SWOG/ECOG intergroup trial S9321 therapy includes VAD induction followed by randomization to high dose melphalan with autologous transplant support. Paticularly important toxicities with VAD include infection, thrombosis and hyperglycemia; and with melphalan toxicities in GI function are noted. Toxicities and genotypes were assessable during VAD induction on 569 patients; and during high dose melphalan on 161 patients. Toxicities examined included an array of symptoms: cardiovascular, flu-like, GI, neurologic, infection, lung, metabolic, and pain. Grade 3 toxicities found in at least 20 patients were compared to SNP genotypes. For VAD induced toxicities,TNF-alpha SNP genotypes showed association with fatigue, dyspnea and thrombosis; CYP3A4 SNP genotypes showed association with fatigue; DNA repair SNP genotypes in XRCC1 showed associations with infection, hyperglycemia and dyspnea; LT-alpha SNP genotypes showed association with dyspnea; and IL-6 and IL-10 SNP genotypes were marginally associated with neuropathy. After high dose melphalan, diarrhea was associated with SNP genotypes in TGF-beta, CYP3A4 and ERCC2. Interestingly, IL-6 polymorphisms were significantly associated with infection. The p values on the above associations ranged from .05 to .004. In addition, we noted ethnic distributions of some SNP genotypes were significantly different; and significant ethnic disparities in therapy induced hyperglycemia, fatigue, dyspnea and thrombosis were noted (p values range from .04 to .009). Of particular note is that the high producer IL-6 genotype is present in over 90% African Americans, compared to 35% Caucasians. Details of each association will be presented. Not all associations can easily be explained by known biologic function of the genotype, and it is important to qualify these results, as the likelihood of seeing some genotype associations by chance is quite high given the number of comparisons made. Further, we are continuing to examine additional prognostic factors that may, together with genotypes, provide collective predictors of toxicities. We consider these associations as targets for further study through the increasing sample acquisition in the Bank On A Cure project.
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Peterson, Katie, Tracy Schohr, Kasey DeAtley, and Zach D. McFarlane. "PSI-34 Factors influencing bull selection and management in extensive rangeland production systems of California." Journal of Animal Science 98, Supplement_4 (2020): 475–76. http://dx.doi.org/10.1093/jas/skaa278.830.

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Abstract California’s 660,000 head of beef cattle are highly dependent on bulls used to produce offspring that can perform across the state’s diverse ecological regions. Bulls need to be functional on rugged coastal landscapes, rolling foothills, deserts and in high-elevation terrain. Few data exist that indicate factors related to selection, maintenance and longevity of bulls used in rangeland landscapes. Objectives herein, were to assess factors influencing bull purchasing, management, and culling decisions of California beef producers. Surveys were mailed to the California Cattlemen’s Association membership (n = 1,410) with ~ 12% response rate (n = 171). Data were analyzed for 56% of respondents (n = 95). Mean age and years of bull selection experience of respondents was 61 ± 1 years and 27 ± 2 years, respectively. Respondents managed cattle on a total of 694,949 ha of owned, private leased, and leased public rangelands in California and surrounding states. Cow-calf herd size was 378 ± 92 head and bull battery averaged 18 ± 3 head with average bull longevity of 5 ± 0.8 years. The average price paid for bulls in the last 2 years was $5166 ± 298, while the highest price paid in the last 5 years was $6958 ± 445. Survey responses were used to define current factors driving management after purchase and for subsequent breeding seasons. Methodology for bull turnout management (i.e. high-energy diet, pasture, supplemental hay) had no impact (P = 0.13) on average age of bulls when culled. After bull purchase, 46% of producers turned bulls out directly with females, while 49% held bulls until the following breeding season. Additionally, most producers (75%) did not manage bulls to reduce condition after purchase. Average bull longevity was moderately correlated (P = 0.01; r2 = 0.30) with average bull price a producer was willing to pay. The average age of bulls when culled was not influenced (P = 0.42) by the frequency of semen quality evaluation. Semen quality was evaluated annually by 45% of respondents, while 20% of respondents never evaluated semen quality. Respondents indicated bull age (35%) and structural soundness (29%) as the most common factors for culling bulls. This research suggests the need for additional research focused on bull selection and management to maximize producer investment in reproduction.
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de PAZ, BANESA, MERCEDES ALPERI-LÓPEZ, FRANCISCO J. BALLINA-GARCÍA та ін. "Interleukin 10 and Tumor Necrosis Factor-α Genotypes in Rheumatoid Arthritis — Association with Clinical Response to Glucocorticoids". Journal of Rheumatology 37, № 3 (2010): 503–11. http://dx.doi.org/10.3899/jrheum.090566.

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Objective.There are dysregulated levels of interleukin 10 (IL-10) and tumor necrosis factor-α (TNF-α) in rheumatoid arthritis (RA), and their role in the disease is controversial. We analyzed the association of functional polymorphisms of IL-10 and TNF-α with susceptibility and disease characteristics at the time of diagnosis, and we also evaluated their possible use as predictors of clinical response to treatments.Methods.Patients with recent-onset RA (n = 162) and healthy controls (n = 373) were genotyped for −1082 IL-10 and −308 TNF-α polymorphisms and data were related to clinical and immunological measurements of patients at the time of diagnosis. Response to treatment after 6 months was determined in 125 patients by the absolute change in Disease Activity Score (DAS28) and the American College of Rheumatology criteria for improvement.Results.We found a reduced frequency of the low IL-10 producer genotype (−1082AA) in patients with RA compared to controls (26.5% vs 38.9%; p = 0.006), while it is a risk factor for anticyclic citrullinated peptide antibodies (anti-CCP) positivity (p = 0.028). Evaluation of clinical response to treatments indicated that carriage of the high IL-10 genotype was associated with a favorable outcome (p = 0.009), specifically to prednisone therapy (p = 0.0003). No significant effects were observed with TNF-α polymorphism alone; however, in combination with the IL-10 genotype, it increased the strength of these associations.Conclusion.Results show an association between the low IL-10 producer genotype and protection from RA; nevertheless, when other specific genetic and/or environmental factors trigger onset of RA, this genotype may predispose to development of anti-CCP+ RA disease with reduced response to prednisone treatment.
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Van Ness, Brian, John Crowley, Emily Blood, et al. "SNP Genotypes as Prognostic Factors Associated with Staging in Myeloma: The First Combined SNP Association Analysis of SWOG, ECOG, and MRC Clinical Trials from the Bank on a Cure." Blood 106, no. 11 (2005): 3489. http://dx.doi.org/10.1182/blood.v106.11.3489.3489.

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Abstract Although multiple myeloma is clinically defined as the accumulation of clonal, malignant plasma cells in the bone marrow, the disease shows significant heterogeneity with regard to progression and therapeutic response. It is likely that germline genetic polymorphisms contribute significantly to an individual’s disease course and response. Bank On A CureTM (BOAC) is a collaborative project initiated with the International Myeloma Foundation (IMF) to develop a DNA bank of myeloma patient samples, through international cooperation. As the bank continues to expand, it provides a resource for the development of cooperative partnerships to assess specific clinical trials as well as conglomerate data. In this study, we have combined data from 3 phase III trials: ECOG trial E9486 (VBMCP + cyclophosphamide or interferon); SWOG trial 9321 (VAD induction followed by randomization to PBSC-supported high dose therapy versus standard dose therapy of VBMCP); and the MRC7 trial (comparing conventional chemotherapy [ABCM] with intravenous chemotherapy and high dose melphalan [CVAMP + HDM +PBSCT]). Five single nucleotide polymorphisms were examined based on associations demonstrated in previous individual trials: GSTP1, IL-6, LT-a, TNF-a, and ERCC2 (DNA repair). Patient samples included 412 from E9486, 569 from S9321, and 232 from MRC7 (total=1213). As a combined data set, genotype associations with overall survival did not reach statistical significance, suggesting SNP associations with survival may be therapy specific. One single association that did reach significance in the conglomerate data was TNF-a genotype association with age of disease onset (the high producer variant AA genotype showing a 5 year later age of onset than the AG/GG genotypes, or the overall mean of the trial, age 61 vs 56; p=.03). This is interesting in light of reports suggesting high production of TNF-a is found in myeloma patients and may actually promote myeloma. Yet, high production may also delay disease onset due to its role in other immunologic processes. Additional parameters including genotype associations with bone disease, CR rates, toxicities, and stage are being evaluated and will be presented. Preliminary results show that when SNPs from S9321 were included in a linear regression model, genotype risk groups could be identified; showing 73% correct association with ISS stage 1, and 75% correct association with ISS stage 3. This model, however, was not validated in the E9486 trial, with less than 50% genotype predictive ISS stage association. A number of highly significant ethnic genotype associations were noted, and are presented in a separate abstract. Given the likely complex interactions of multiple genetic variations, collective genotype comparisons may be required from larger pooled data sets BOAC is assembling to increase significant associations.
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Seidemann, Kathrin, Martin Zimmermann, Marion Book, et al. "Tumor Necrosis Factor and Lymphotoxin Alfa Genetic Polymorphisms and Outcome in Pediatric Patients With Non-Hodgkin’s Lymphoma: Results From Berlin-Frankfurt-Münster Trial NHL-BFM 95." Journal of Clinical Oncology 23, no. 33 (2005): 8414–21. http://dx.doi.org/10.1200/jco.2005.01.2179.

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Purpose To analyze the association of genetic variation within the tumor necrosis factor (TNF −308 [G→A]) and lymphotoxin alfa (LT-a +252 [A→G]) genes with outcome in non-Hodgkin's lymphoma of childhood and adolescence. Patients and Methods Genotyping of the TNF −308 (G→A) and LT-a +252 (A→G) polymorphisms in patients (n = 488) enrolled onto the German-Austrian-Swiss multicenter trial NHL-BFM 95 from April 1996 to January 2000 was performed by polymerase chain reaction with subsequent restriction fragment length polymorphism analysis on DNA from tumor-free specimen. Results In patients with Burkitt's lymphoma (BL) and B-cell acute lymphoblastic leukemia (B-ALL; n = 219, 211 eligible patients), patients carrying at least two variant alleles (high-producer haplotypes) had an increased risk of events: probability of event-free survival (pEFS) at 3 years was 81% (SE = 5%), compared with 91% (SE = 2%) in low-producer haplotypes (P = .018). In BL/B-ALL with high tumor load (lactate dehydrogenase [LDH] ≥ 500 U/L; n = 104), pEFS was 69% (SE = 8%) in high-producer versus 85% (SE = 4%) in low-producer haplotypes (P = .05). In multivariate analysis including risk factors for events (LDH ≥ 500 U/L, CNS involvement, methotrexate infusion regimen), TNF −308/LT-α +252 haplotype kept prognostic relevance: patients with high-producer haplotypes had a 2.34-fold increase in risk of events (P = .048). The TNF −308 (G→A) and LT-α +252 (A→G) polymorphisms were not associated with pEFS in lymphoblastic lymphoma (n = 101), anaplastic large-cell lymphoma (n = 67), or diffuse large B-cell lymphoma (n = 65), nor with therapy-related toxicity. Conclusion The TNF −308 (G→A) and LT-a +252 (A→G) polymorphisms were negative prognostic factors in pediatric BL/B-ALL. Among patients with serum LDH ≥ 500 U/L, haplotype analysis further determined patients at risk for events.
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PURWANINGSIH, Endang, MUSLIKH MUSLIKH, Nelly Ulfah ANISARIZA, and Derta RAHMANTO. "Legal Protection Towards Traditional Food Based on Mark and Geographic Indication Law." Journal of Advanced Research in Law and Economics 9, no. 1 (2018): 242. http://dx.doi.org/10.14505//jarle.v9.1(31).29.

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Traditional food makers should be empowered and their products should be protected. The objectives of this research are to identify and analyze the potential, the prospect, and the legal protection of traditional food (producer and products) to finally attain legal protection and trademark or geographic indication. In this research, the method applied is analytical descriptive qualitative by making use of participatory (PRA) and sociological-juridical approaches. The research findings suggest that so far, instead of working on a bigger cause that is achieving mark/label, traditional food producers are still striving for trademark merely to get market distribution and halal label. It is clear that they need help from related parties considering their economy, sociological humanities (empowerment), and legal aspects (regulation, policy, brand, halal label, consumer protection). Related parties, the Industry and Trade Service, Cooperatives and SME’s, Directorate General of Property Rights and its regional office, the Department of Agriculture, universities, and the traditional food producers association—should work together and take serious measures to pro-actively involve food makers.
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Abadega, Abduselam Faris. "Potato Market Participation and Its Extents Evidence from Southwest Ethiopia: A Double Hurdle Approach." AGRARIS: Journal of Agribusiness and Rural Development Research 7, no. 1 (2021): 53–63. http://dx.doi.org/10.18196/agraris.v7i1.9912.

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Potato is an important commodity for livelihood in many parts of Ethiopia. Potato producers in Ethiopia face sophisticated marketing challenges, including inadequate access to market and low amount of marketed surpluses due to subsistence-oriented production of potato. The study aimed to identify factors that determine the market participation and its extents. About 136 potato producers were selected randomly from peasant association found in Dedo Districts of Ethiopia. Quantitative and qualitative data were collected from primary sources. Descriptive and econometric methods of data analysis were used to analyze data from the survey. A double hurdle model was applied to investigate factors affecting market participation and its extents. Results of descriptive statistics revealed that out of the total sample producer, 87.5 % of sample household has participated in the potato market. Age, sex, education, land size allocated for potato, and non-farm income were significantly influencing potato market participation. Age, sex, education (years of schooling), non-farm income, active labor and land allocated for potato influenced smallholder farmers level of market participation.
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Ahmed Khudhair, Haneen. "Modelling, Composition and production rate of medical solid waste in Tikrit: A case study of Tikrit Teaching Hospital (TTH) in Iraq." Journal of advanced Sciences and Engineering Technologies 1, no. 2 (2018): 73–83. http://dx.doi.org/10.32441/jaset.v1i2.177.

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Tikrit Teaching Hospital (TTH), Tikrit, Iraq, was selected for investigation as a case study. Data collection was carried out during TTH visits and by questionnaires. Sampling was performed during a 10-month period, one week each sampling month. The medical waste analyzed was comprised of 63.04% general waste (non-risk) and 36.96% hazardous waste. The results indicated that the medical waste generation rate is 0.9 kg/bed.day and 0.75 kg/patient.day. Statistically significant linear correlations were established between the daily production of medical solid waste and the respective number of patients and the occupied beds in TTH as whole. Based on the average daily production of medical solid waste produced by the departments of TTH (kg /d), the larger producer of general medical solid waste was obstetric department with average daily production of 25 kg/d, while the larger producer of hazardous medical solid waste was obstetric department with average daily production of 11 kg/d. The average specific weight of total medical waste, general waste, and hazardous waste were determined to be 218.6, 206.5 and 225.54 kg/m3, respectively. The average moisture content of total medical waste, general waste, and hazardous waste were determined to be 21, 20.4 and 23.4 %, respectively. The average general medical waste composition was: 40% organics, 21% plastics, 19% paper, 11% glass and 9% metals. Pathological wastes and sharp objects comprised 43% and 25% of the hazardous medical waste components.
 
 © 2018 JASET, International Scholars and Researchers Association
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Soma, Kana, Gotoh Nanami, Tetsuhiro Kasamatsu, et al. "Th1 Cytokine Polymorphism Gene: TNF-Alpha -857C/T Affects the Pathogenesis and Progression of Acute Myeloid Leukemia." Blood 134, Supplement_1 (2019): 1431. http://dx.doi.org/10.1182/blood-2019-129409.

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Background: Acute myeloid leukemia (AML) is a hematological malignancy characterized by the autonomous growth of immature myeloid cells with impaired differentiation and maturation. Cytokines are low-molecular-weight proteins that play a basic and fundamental role in communication within the immune system. Cytokines induce various effects such as differentiation, proliferation, hematopoiesis, and inflammation of target cells. AML is also closely associated with cytokine networks in terms of proliferation, apoptosis, and differentiation of leukemic cells. Cytokines produced by Th1 involved in cell-mediated immunity are called Th1 cytokines. Th1 cytokine includes TNF-α and IL-2. Several studies have reported that TNF-α is highly expressed in leukemia cells with AML patients. Other studies have also reported that high serum level of TNF-α of AML patients is associated with poor survival outcome. However, the association between Th1 cytokine polymorphisms: TNF-α -857C/T and IL-2-330T/G and the pathogenesis of AML is unclear. Therefore, we investigated the role of these polymorphisms in AML. Materials and Methods: This study included 101 patients with AML [male/female, 56/45; age, 15-86 years; median age, 58 years; MRC classification favorable (n = 38), intermediate (n =56), and adverse (n = 7)] and 202 healthy race-matched controls. All participants provided written informed consent. This study was approved by the Institutional Review Board of Gunma University Hospital. Genotyping was performed by the polymerase chain reaction (PCR)-restriction fragment length polymorphism method. Genotype and allele frequency were compared between patient group and control group by χ2-test. Clinical features were compared using Student's t and χ2 tests. Overall survival (OS) and leukemia free survival (LFS) were calculated using the Kaplan-Meier method. Survival curves were compared using the log-rank test. Analyses were performed using the SPSS software package ver. 25 (IBM, Armonk, NY, USA). P < 0.05 was considered to represent statistical significance. Results: TNF-α -857 C/T nonCC genotype (higher producer type) increases the risk of AML (AML vs. controls = 39.6% vs. 28.2%, OR = 1.67, 95% CI = 1.01-2.75, p = 0.045). Moreover, the frequency of TNF-α -857 C/T T allele (higher producer type) was higher in AML patients compared to controls (AML vs. controls = 24.8% vs. 16.8%, OR = 1.625, 95%CI = 1.078-2.451 p = 0.02). There was no significant difference between AML patients and controls in genotype and allele frequencies of IL-2 -330 T/G. In the analysis of clinical features, the average platelet count was significantly lower in TNF-α -857 C/T TT genotype (higher producer type) (TT vs. nonTT = 2.4±1.4 vs. 4.4±5.9, p < 0.01). TT genotype (higher producer type) was also significantly higher in frequency of MRC classification adverse (TT vs. nonTT = 30.0% vs. 4.4%, p = 0.02) and history of tumor (TT vs. nonTT = 30.0% vs. 6.6%. p =0.04). Moreover, in survival time analysis, patients with TNF-α -857 C/T TT genotype (higher producer type) had significantly shortened OS compared with patients with nonTT genotype (lower producer type) (TT vs. nonTT = 17.2 months vs not reached, p < 0.01). Patients with TT genotype (high producer type) also experienced significantly shortened LFS (TT vs. nonTT = 24.0 months vs not reached, p = 0.04). Furthermore, multivariate analysis of OS revealed TNF-α -857 C/T TT genotype (higher producer type) as an independent prognostic factor (HR = 3.01, 95% CI = 1.04-8.69, p = 0.04), like age and white blood cell count. Conclusion: These results suggest that TNF-α-857 C/T T allele (higher producer type) increases the risk of AML. Furthermore, TNF-α-857 C/T TT genotype (higher producer type) affects the poor prognosis. Therefore, these data suggest the new role of TNF-α polymorphism in AML leukemogenesis. Figure Disclosures Handa: Ono: Research Funding.
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Mellers, Greg, Jorge González Aguilera, Nick Bird, et al. "Genetic Characterization of a Wheat Association Mapping Panel Relevant to Brazilian Breeding Using a High-Density Single Nucleotide Polymorphism Array." G3: Genes|Genomes|Genetics 10, no. 7 (2020): 2229–39. http://dx.doi.org/10.1534/g3.120.401234.

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Bread wheat (Triticum aestivum L.) is one of the world’s most important crops. Maintaining wheat yield gains across all of its major production areas is a key target toward underpinning global food security. Brazil is a major wheat producer in South America, generating grain yields of around 6.8 million tons per year. Here, we establish and genotype a wheat association mapping resource relevant to contemporary Brazilian wheat breeding programs. The panel of 558 wheat accessions was genotyped using an Illumina iSelect 90,000 single nucleotide polymorphism array. Following quality control, the final data matrix consisted of 470 accessions and 22,475 polymorphic genetic markers (minor allele frequency ≥5%, missing data <5%). Principal component analysis identified distinct differences between materials bred predominantly for the northern Cerrado region, compared to those bred for southern Brazilian agricultural areas. We augmented the genotypic data with 26 functional Kompetitive Allele-Specific PCR (KASP) markers to identify the allelic combinations at genes with previously known effects on agronomically important traits in the panel. This highlighted breeding targets for immediate consideration – notably, increased Fusarium head blight resistance via the Fhb1 locus. To demonstrate the panel’s likely future utility, genome-wide association scans for several phenotypic traits were undertaken. Significant (Bonferroni corrected P < 0.05) marker-trait associations were detected for Fusarium kernel damage (a proxy for type 2 Fusarium resistance), identifying previously known quantitative trait loci in the panel. This association mapping panel represents an important resource for Brazilian wheat breeding, allowing future genetic studies to analyze multiple agronomic traits within a single genetically diverse population.
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Pratama, Fredie, and Jono M. Munandar. "Analisis Brand Equity Pocari Sweat Dalam Persaingan Industri Minuman (Studi Kasus: Mahasiswa di Bogor)." Jurnal Manajemen dan Organisasi 1, no. 1 (2016): 24. http://dx.doi.org/10.29244/jmo.v1i1.14147.

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<em>Isotonic drink is a new kind of product in Indonesian consumer goods. This kind of product entered Indonesian market in mid-80s. However, isotonic drink industry is growing up along with the increase of people’s welfare and awareness of body health. One of isotonic drinks marketed in Indonesia is Pocari Sweat, produced by PT Amerta Indah Otsuka, which is the market leader in Indonesian isotonic drink industry. High level of competition put more burdens on the producer. PT Amerta has to ensure that Pocari Sweat get a strong position on consumers’ minds. The objective of this research is to analyze Pocari Sweat’s brand equity. It covers several elements: brand awareness, brand association, brand’s perceived quality and brand loyalty. In order to see the overall competition among isotonic drinks, this research also involves several other brands such as ProSweat, Mizone, Aqua, and Coca-Cola. This research is conducted in three universities in Bogor; Bogor Institute of Agriculture (Institut Pertanian Bogor), Pakuan University and Ibnu Khaldun University. The result shows that in the element of brand awareness, Pocari Sweat is the most memorized brand. The association of brand image in brand association element shows that Pocari Sweat has two brand images: safe for health and fresh taste to kill thirst. Analysis on perceived quality with biplot method shows that Pocari Sweat has several attributive characteristics namely benefit, safe for health, eliminates dehydration and recharge stamina. Meanwhile, analysis in brand loyalty shows that Pocari Sweat doesn’t have a strong brand loyalty yet.</em>
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Thornton, L., S. Gray, P. Bingham, et al. "The problems of tracing a geographically widespread outbreak of salmonellosis from a commonly eaten food: Salmonella typhimurium DT193 in North West England and North Wales in 1991." Epidemiology and Infection 111, no. 3 (1993): 465–72. http://dx.doi.org/10.1017/s0950268800057198.

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SummaryGeographically widespread outbreaks involving commonly isolated organisms and where the vehicles of infection are commonly eaten foodstuffs pose particular difficulties at a technical and organizational level.An outbreak of Salmonella typhimurium infection, affecting 39 people, spread over a wide area in North West England and North Wales in April and May 1991, was detected thanks to the practice of sending specimens to the national reference laboratory where phage typing and characterizing of antibiotic resistance patterns enabled the identification of a cluster of distinctive isolates (S. typhimurium DT193 resistant to sulphonamides, trimethoprim and furazolidone). An investigation, involving twenty environmental health departments in addition to health authorities and the Public Health Laboratory Service, showed an association between the illness and eating loose sliced cooked ham (P = 0.004). Detailed tracing of the chain of supply of the ham showed this to be particularly cooked ham originating from a single small local producer (P = 0.00003). Further investigation of that producer revealed that a batch of ham distributed on one day in early April was undercooked due to a malfunction in cooking equipment.
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O'Mahony, M., J. Cowden, B. Smyth, et al. "An outbreak of Salmonella saint-paul infection associated with beansprouts." Epidemiology and Infection 104, no. 2 (1990): 229–35. http://dx.doi.org/10.1017/s0950268800059392.

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SUMMARYIn March 1988, there was an outbreak of infection by a strain of Salmonella saint-paul with a distinctive antigenic marker. A total of 143 reports were received between 1 March and 7 June. Preliminary investigations suggested that raw beansprouts were a possible source of infection and a case-control study confirmed the association. S. saint-paul of the epidemic type was isolated from samples of beansprouts on retail sale in different cities in the United Kingdom and from mung bean seeds on the premises of the producer who was most strongly associated with cases. In addition, Salmonella virchow PT34 was isolated from samples of raw beansprouts and was subsequently associated with seven cases of infection. Four other serotypes of salmonella were also isolated from beansprouts. On 8 April the public were advised to boil beansprouts for 15 seconds before consumption, and the premises of the one producer associated with many cases were closed. As a result of these actions there was a significant decrease in the number of infections with S. saint-paul.
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45

Castro-Santos, Patricia, Ana Suarez, Laureano Lopez-Rivas, Lourdes Mozo, and Carmen Gutierrez. "TNFalpha and IL-10 Gene Polymorphisms in Inflammatory Bowel Disease. Association of -1082 AA Low Producer IL-10 Genotype with Steroid Dependency." American Journal of Gastroenterology 101, no. 5 (2006): 1039–47. http://dx.doi.org/10.1111/j.1572-0241.2006.00501.x.

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46

Eser, Hakkı, and Nermin Bahşi. "Konya İli Ilgın İlçesinde Şeker Pancarı Üretim Yapısı ve Sorunlar." Turkish Journal of Agriculture - Food Science and Technology 8, no. 1 (2020): 204. http://dx.doi.org/10.24925/turjaf.v8i1.204-213.2963.

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In this study, it is aimed to determine sugar beet production in Konya province, operation of factories in the region, the situation of farmers, privatization, production structure of sugar beet and the problems based on it. For this purpose, data were collected by questionnaires from 175 producers, who were selected according to Probability-Based Sampling method, from the producers operating in the cooperatives registered in the Association of Beet Cultivators Cooperatives (Pankobirlik) in Ilgın district of Konya. According to the findings, the difficulties encountered in production were listed as high irrigation cost of sugar beet (87.4%), difficulty in combating diseases and pests (77.7%), excess labor demand compared to other products (74.3%), and insufficiency of water in the region (72.0%) in sugar beet production. In addition, about 77% of producer’s state that product prices are low. Approximately 60% of the producers in the region have stated that they are against the privatization of sugar producing factories. When the results are evaluated, it is necessary to take into consideration the costs in determining sugar beet purchase prices and to include sugar beet production within the scope of support to reduce production costs. In addition, it is considered necessary to take essential steps by considering producer opinions on privatization and to review sugar policies.
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Adams, Nancy E. "A Comparison of Evidence-Based Practice and the ACRL Information Literacy Standards: Implications for Information Literacy Practice." College & Research Libraries 75, no. 2 (2014): 232–48. http://dx.doi.org/10.5860/crl12-417.

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Evidence-based practice (EBP), like information literacy, is concerned with an individual’s knowledge, skills, and attitudes relating to using information. EBP is now a professional competency in fields as diverse as social work, nursing and allied health fields, and public policy. A comparison of the Association of College and Research Libraries’ Information Literacy Competency Standards for Higher Education with the commonly accepted EBP model shows congruence, but the two models diverge in their use of authority of the producer as a marker of information quality and in their relative emphasis on formulation of the research question and application of information.
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Natoubi, Samira, Abouddihaj Barguigua, Nezha Baghdad та ін. "OCCURRENCE OF CARBAPENEMASES AND EXTENDED-SPECTRUM ΒETA-LACTAMASES IN UROPATHOGENIC ENTEROBACTERIACEAE ISOLATED FROM A COMMUNITY SETTING, SETTAT, MOROCCO". Asian Journal of Pharmaceutical and Clinical Research 10, № 1 (2016): 211. http://dx.doi.org/10.22159/ajpcr.2017.v10i1.14924.

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ABSTRACTObjective: Urinary tract infections (UTIs) are still commonly diagnosed in outpatients as well as in hospitalized patients. In this study, weinvestigated the prevalence and performed molecular characterization of extended-spectrum-β-lactamases (ESBL) and carbapenemases produced byEnterobacteriaceae isolates that cause community UTIs in Settat city, Morocco.Methods: From January 2012 to December 2013, all uropathogenic community Enterobacteriaceae isolates were collected from the microbiologylaboratory of Hassan II Hospital, Settat, Morocco. Antibiotic susceptibility testing was performed as recommended by Clinical and LaboratoryStandard Institute. Phenotypic identification of ESBL and carbapenemase producer isolates was confirmed by the double-disk synergy test and themodified Hodge test, respectively. Molecular characterization of β-lactamase genes was performed using polymerase chain reaction (PCR), followedby sequencing of the obtained products.Results: Among 153 isolates, 31 (20.26%) were multi-drug resistant (MDR). Nine strains (5.88%) were ESBL producers, of which Klebsiellapneumoniae (n=5; 20.83%), Escherichia coli (n=3; 3.15%), and Enterobacter cloacae (n=1; 9.09%) species were identified. The results of ESBLencodinggenedetectionby sequencing revealed the presence of CTX-M-15 (n=9) in association with other β-lactamase genes such as temoneira 1(n=8) and sulfhydryl variable 1 (n=5). According to the modified Hodge test and PCR, three isolates (1.96%) were positive carry the blaConclusion: The emergence of MDR uropathogenic Enterobacteriaceae isolates in our community is highly alarming. Strict measures will be requiredto control the further spread of these uropathogenic isolates.Keywords: Carbapenemase, Enterobacteriaceae, Extended-spectrum-β-lactamases, Moroccan community.OXA-48 gene.
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Carvalho, Isabel, Nadia Safia Chenouf, José António Carvalho та ін. "Multidrug-resistant Klebsiella pneumoniae harboring extended spectrum β-lactamase encoding genes isolated from human septicemias". PLOS ONE 16, № 5 (2021): e0250525. http://dx.doi.org/10.1371/journal.pone.0250525.

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Klebsiella pneumoniae is a major pathogen implicated in nosocomial infections. Extended-spectrum β-lactamase (ESBL)-producing K. pneumoniae isolates are a public health concern. We aim to characterize the type of β-lactamases and the associated resistance mechanisms in ESBL-producing K. pneumoniae isolates obtained from blood cultures in a Portuguese hospital, as well as to determine the circulating clones. Twenty-two cefotaxime/ceftazidime-resistant (CTX/CAZR) K. pneumoniae isolates were included in the study. Identification was performed by MALDI-TOF MS and the antimicrobial susceptibility testing by disk-diffusion. The screening test for ESBL-production was performed and ESBL-producer isolates were further characterized. The presence of different beta-lactamase genes (blaCTX-M, blaSHV, blaTEM, blaKPC, blaNDM, blaVIM, blaOXA-48, blaCMY-2, blaDHA-1, blaFOX, blaMOX, and blaACC) was analyzed by PCR/sequencing in ESBL-producer isolates, as well as the presence of other resistance genes (aac(6’)-Ib-cr, tetA/B, dfrA, qnrA/B/S, sul1/2/3) or integron-related genes (int1/2/3). Multilocus-sequence-typing (MLST) was performed for selected isolates. ESBL activity was detected in 12 of the 22 CTX/CAZR K. pneumoniae isolates and 11 of them carried the blaCTX-M-15 gene (together with blaTEM), and the remaining isolate carried the blaSHV-106 gene. All the blaCTX-M-15 harboring isolates also contained a blaSHV gene (blaSHV-1, blaSHV-11 or blaSHV-27 variants). Both blaSHV-27 and blaSHV-106 genes correspond to ESBL-variants. Two of the CTX-M-15 producing isolates carried a carbapenemase gene (blaKPC2/3 and blaOXA-48) and showed imipenem resistance. The majority of the ESBL-producing isolates carried the int1 gene, as well as sulphonamide-resistance genes (sul2 and/or sul3); the tetA gene was detected in all eight tetracycline-resistant isolates. Three different genetic lineages were found in selected isolates: ST348 (one CTX-M-15/TEM/SHV-27/KPC-2/3-producer isolate), ST11 (two CTX-M-15/TEM/SHV-1- and CTX-M-15-TEM-SHV-11-OXA-48-producer isolates) and ST15 (one SHV-106/TEM-producer isolate). ESBL enzymes of CTX-M-15 or SHV-type are detected among blood K. pneumoniae isolates, in some cases in association with carbapenemases of KPC or OXA-48 type.
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Ma, Youwen, and Yi Wan. "Data Analysis Method of Intelligent Analysis Platform for Big Data of Film and Television." Complexity 2021 (April 16, 2021): 1–10. http://dx.doi.org/10.1155/2021/9947832.

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Based on cloud computing and statistics theory, this paper proposes a reasonable analysis method for big data of film and television. The method selects Hadoop open source cloud platform as the basis, combines the MapReduce distributed programming model and HDFS distributed file storage system and other key cloud computing technologies. In order to cope with different data processing needs of film and television industry, association analysis, cluster analysis, factor analysis, and K-mean + association analysis algorithm training model were applied to model, process, and analyze the full data of film and TV series. According to the film type, producer, production region, investment, box office, audience rating, network score, audience group, and other factors, the film and television data in recent years are analyzed and studied. Based on the study of the impact of each attribute of film and television drama on film box office and TV audience rating, it is committed to the prediction of film and television industry and constantly verifies and improves the algorithm model.
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