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Journal articles on the topic 'Produit à base de cellules ou tissus'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Donné, Romain, Maëva Saroul, Vanessa Maillet, Séverine Celton-Morizur, and Chantal Desdouets. "La polyploïdie hépatique." médecine/sciences 35, no. 6-7 (2019): 519–26. http://dx.doi.org/10.1051/medsci/2019094.

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La polyploïdie (amplification du génome entier) fait référence à des organismes dont les cellules ont plus de deux jeux complets de chromosomes homologues. La polyploïdie a été observée pour la première fois chez les plantes, il y a plus d'un siècle. Il est dorénavant connu que ce processus se produit chez de nombreux eucaryotes dans diverses circonstances. Chez les mammifères, le développement de cellules polyploïdes peut contribuer à la différenciation des tissus. Il peut donc présenter un gain de fonction. Alternativement, il peut être associé au développement de différentes pathologies com

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Maumus, Marie, Yves-Marie Pers, Maxime Ruiz, Christian Jorgensen, and Danièle Noël. "Cellules souches mésenchymateuses et médecine régénératrice." médecine/sciences 34, no. 12 (2018): 1092–99. http://dx.doi.org/10.1051/medsci/2018294.

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Les cellules souches mésenchymateuses (CSM) sont des cellules adultes multipotentes isolées de plusieurs tissus. Une thérapie à base de CSM dans l’arthrose est justifiée par leurs capacités de différenciation et leurs propriétés paracrines. Les stratégies thérapeutiques comprennent l’injection articulaire de CSM ou leur implantation combinée à des biomatériaux. Selon leur mode d’administration et leur devenir, elles peuvent diminuer l’inflammation, prévenir l’hypertrophie et l’apoptose des chondrocytes et/ou se différencier en chondrocytes. Nous résumons ici les données physiopathologiques et

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Lawrence, J. A., A. P. Whiteland, J. Malika, P. Kafuwa, and Frans Jongejan. "Utilisation de la réponse sérologique pour évaluer l’immunisation de bovins contre la cowdriose." Revue d’élevage et de médecine vétérinaire des pays tropicaux 46, no. 1-2 (1993): 211–15. http://dx.doi.org/10.19182/remvt.9365.

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Du vaccin congelé à base de sang contenant la souche Ball 3 de Cowdria ruminantium est produit par un projet FAO/DANIDA au Malawi pour l'immunisation de bovins laitiers améliorés contre la cowdriose. L'immunogénicité des lots de vaccin a été quantifiée et des régimes différents d'immunisation ont été évalués par l'utilisation d'immunofluorescence indirecte pour déterminer les taux d'anticorps générés. Des cellules endothéliales infectées, en culture, ont été utilisées comme antigène. La proportion d'animaux montrant une réponse sérologique variait entre différents lots de vaccin testés en même

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Igual Luis, David. "Las galeras mercantiles venecianas y el puerto de Valencia (1391-1534)." Anuario de Estudios Medievales 24, no. 1 (2020): 179. http://dx.doi.org/10.3989/aem.1994.v24.970.

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Cet article a analysé le fonctionnement de la navigation des galere da mercato vénitiennes le long d'un des. littoraux parcourus, la côte de Valence. Ce système connu comptait aux XIVe-XVIe siècles jusque sept routes et servit à approvisionner l'Occident en produit orientaux et aussi pour acheter des marchandises dans les points d'arrêt. Les premières galères qui arrivèrent au port de Valence (celles de Flandres) sont de 1391, mais la période la plus active de l’escale est celle des années 1450-1534 avec la route d'Aigues Mortes et de Berberie. Précisement, l'analyse combinée des sources fis

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SELLIER, P., J. BOUIX, G. RENAND, and M. MOLÉNAT. "Les objectifs et les critères de sélection : Les aptitudes bouchères : croissance, efficacité alimentaire et qualité de la carcasse." INRAE Productions Animales 5, HS (1992): 147–59. http://dx.doi.org/10.20870/productions-animales.1992.5.hs.4278.

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Les programmes de sélection sur les aptitudes bouchères ont un double objectif : l’abaissement du coût de production et l’amélioration de la qualité du produit. Cet article rappelle un certain nombre de données de base sur les aptitudes bouchères : courbe de croissance, évolution de la composition chimique et tissulaire chez l’animal en croissance (notion d’allométrie), énergétique de la croissance (relation entre efficacité alimentaire et croissance musculaire), développement des tissus musculaire et adipeux, qualités de la viande et du gras. Les objectifs et les critères de sélection sont dé

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Brézulier, Damien, Pascal Pellen-Mussi, Olivier Sorel, and Sylvie Jeanne. "La mécanobiologie osseuse, un domaine émergeant : revue de littérature." L'Orthodontie Française 89, no. 4 (2018): 343–53. http://dx.doi.org/10.1051/orthodfr/2018034.

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Introduction : La mécanobiologie, à l’interface entre biologie et biophysique, étudie l’incidence des forces mécaniques sur les tissus, les cellules et les biomolécules. L’application de forces orthodontiques, suivie du déplacement dentaire provoqué, est un exemple marquant de son application clinique. Objectif : L’objectif de cet article était de dresser une revue de la littérature sur le sujet de la mécanobiologie ; de sa mise en évidence au niveau osseux à l’exposé des voies intracellulaires stimulées. Matériels et méthodes : La recherche bibliographique a été menée sur la base de données P

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De Santis, Rita, Claudio Albertoni, Antonio Rosi, et al. "OXavidin for Tissue Targeting Biotinylated Therapeutics." Journal of Biomedicine and Biotechnology 2009 (2009): 1–9. http://dx.doi.org/10.1155/2009/921434.

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Avidin is a glycoprotein from hen egg white that binds biotin with very high affinity. Here we describe OXavidin, a product containing aldehyde groups, obtained by ligand-assisted sugar oxidation of avidin by sodium periodate. OXavidin chemically reacts with cellular and tissue proteins through Schiff's base formation thus residing in tissues for weeks while preserving the biotin binding capacity. The long tissue residence of OXavidin as well as that of OXavidin/biotinylated agent complex occurs in normal and neoplastic tissues and immunohistochemistry shows a strong and homogenous stromal loc

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RUPP, R., D. BOICHARD, C. BERTRAND, and S. BAZIN. "Bilan national des numérations cellulaires dans le lait des différentes races bovines laitières françaises." INRAE Productions Animales 13, no. 4 (2000): 257–67. http://dx.doi.org/10.20870/productions-animales.2000.13.4.3785.

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Cet article présente le premier bilan descriptif des données de numérations cellulaires disponibles dans la base de données nationale pour les principales races bovines laitières au Contrôle Laitier, depuis 1995. Les numérations cellulaires varient avec la race, le lait des vaches des races les moins productives (Abondance, Simmental Française) étant moins concentré en cellules que celui des races plus productives (Prim’Holstein, Pie Rouge des Plaines). Ces différences entre races se maintiennent à niveau de production équivalent. Elles ne sont donc pas attribuable au niveau de production en t

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MULSANT, P. "Glossaire général." INRAE Productions Animales 24, no. 4 (2011): 405–8. http://dx.doi.org/10.20870/productions-animales.2011.24.4.3273.

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Allèle : une des formes alternatives d'un locus. Dans une cellule diploïde, il y a deux allèles pour chaque locus (un allèle transmis par chaque parent), qui peuvent être identiques. Dans une population, on peut avoir plusieurs allèles pour un locus.Annotation structurale : repérage des coordonnées des diverses structures dans le génome, telles que les gènes.Annotation fonctionnelle : renseignements sur les fonctions des séquences, le plus souvent pour les gènes.BAC : Bacterial Artificial Chromosome. Vecteur de clonage permettant l’obtention de clones bactériens contenant un grand fragment d’A

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Serena, Thomas E., Raphael A. Yaakov, and Eliot N. Mostow. "Use of Cellular and Tissue-based Product in the Treatment of Diabetic Foot Ulcers." Journal of Foot and Ankle Surgery (Asia Pacific) 3, no. 2 (2016): 92–96. http://dx.doi.org/10.5005/jp-journals-10040-1055.

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ABSTRACT Introduction The prevalence of diabetes has been rising sharply and the rise in chronic wounds parallels this trend. Lower extremity ulcers present a serious complication for people with diabetes. While debridement of necrotic tissue and off-loading plays an important role in wound healing, many patients with diabetic foot ulcers (DFUs) fail to heal with standard of care (SOC) alone. Unresolved ulcers can lead to complications, such as osteomyelitis and amputation. There continues to be a need for the evaluation of novel wound therapies that can accelerate wound healing and lower the

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D'Amore-Bruno, M. A., K. A. Wikenheiser, J. E. Carter, J. C. Clark, and J. A. Whitsett. "Sequence, ontogeny, and cellular localization of murine surfactant protein B mRNA." American Journal of Physiology-Lung Cellular and Molecular Physiology 262, no. 1 (1992): L40—L47. http://dx.doi.org/10.1152/ajplung.1992.262.1.l40.

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We have isolated and characterized murine surfactant protein (SP-B) cDNAs and determined both the cellular distribution and developmental expression of SP-B mRNA. The nucleotide sequence of the composite SP-B cDNAs and cloned genomic SP-B DNA predicted a primary translation product of 377 amino acids (molecular mass = 41.7 kDa) that contained a single asparagine linked glycosylation site. The 410 base 3' untranslated region contained a novel sequence consisting of a (CCA)21 repeat. Tissue specificity and developmental expression of SP-B mRNA was assessed by Northern blot analysis. A single 1.6

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Alary, Anouck. "La conservation autologue de sang de cordon ombilical : vers une nouvelle forme de participation biocitoyenne ?" Les ateliers de l'éthique 11, no. 2-3 (2017): 28–64. http://dx.doi.org/10.7202/1041765ar.

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La transformation du sang placentaire en une précieuse source de cellules souches a donné naissance à partir des années 1990 à une industrie globale de conservation de sang de cordon ombilical faisant désormais concurrence à un large réseau de banques publiques de sang de cordon. Cet article explore les soubassements socioculturels liés à l’émergence de cette industrie et tente d’élucider les enjeux éthiques et politiques qu’elle pose. Si les banques publiques de sang de cordon sont porteuses des valeurs d’altruisme et de solidarité nationale traditionnellement liées au modèle redistributif d’

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Nucera, E., C. Nicoletti, C. Chiapparino, et al. "AvidinOX® for Tissue Targeted Delivery of Biotinylated Cells." International Journal of Immunopathology and Pharmacology 25, no. 1 (2012): 239–46. http://dx.doi.org/10.1177/039463201202500126.

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AvidinOX® a product containing aldehyde groups, generated by ligand-assisted sugar oxidation of avidin by sodium periodate, maintains the capacity to bind biotin with very high affinity and exhibits the property to chemically link cellular and tissue proteins through Schiff's base formation thus residing in tissues for weeks. In recent studies, we have shown that AvidinOX exhibits much higher persistency in the skeletal muscle than native avidin. The aim of the present study is to evaluate whether AvidinOX-biotin interaction might be exploited to target biotinylated cells to an AvidinOX pre-tr

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Umar, Shahid, Jason Scott, Joseph H. Sellin, William P. Dubinsky, and Andrew P. Morris. "Murine colonic mucosa hyperproliferation. I. Elevated CFTR expression and enhanced cAMP-dependent Cl−secretion." American Journal of Physiology-Gastrointestinal and Liver Physiology 278, no. 5 (2000): G753—G764. http://dx.doi.org/10.1152/ajpgi.2000.278.5.g753.

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Fluid transport in the large intestine is mediated by the cystic fibrosis gene product and cAMP-dependent anion channel cystic fibrosis transmembrane conductance regulator (CFTR). cAMP-mediated Cl−secretion by gastrointestinal cell lines in vitro has been positively correlated with the insertion of CFTR into the apical membrane of differentiated senescent colonocytes and negatively correlated with the failure of CFTR to insert into the plasma membrane of their undifferentiated proliferating counterparts. In native tissues, this relationship remains unresolved. We demonstrate, in a transmissibl

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Haque, Md Obaidul, and Md Ibrahim H. Mondal. "Synthesis and Characterization of Cellulose-based Eco-Friendly Hydrogels." Rajshahi University Journal of Science and Engineering 44 (November 19, 2016): 45–53. http://dx.doi.org/10.3329/rujse.v44i0.30386.

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Biodegradable nature of hydrogels is highly appreciable and core expectation at present time. Cellulose and cellulose derivatives can be copolymerized in producing green hydrogels for improving the absorption performance of many adsorbent products. Hydrogels are polymeric substances and due to hydrophilic functional groups in their structure capable of holding large amount of water compared to its body mass. Crosslinking is one of the simplest reactions used to improve the physico-chemical properties of cellulose and cellulose derivatives. In the present paper an innovative cellulose based env

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Jumpathong, Watthanachai, Wan Chan, Koli Taghizadeh, I. Ramesh Babu, and Peter C. Dedon. "Metabolic fate of endogenous molecular damage: Urinary glutathione conjugates of DNA-derived base propenals as markers of inflammation." Proceedings of the National Academy of Sciences 112, no. 35 (2015): E4845—E4853. http://dx.doi.org/10.1073/pnas.1503945112.

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Although mechanistically linked to disease, cellular molecules damaged by endogenous processes have not emerged as significant biomarkers of inflammation and disease risk, due in part to poor understanding of their pharmacokinetic fate from tissue to excretion. Here, we use systematic metabolite profiling to define the fate of a common DNA oxidation product, base propenals, to discover such a biomarker. Based on known chemical reactivity and metabolism in liver cell extracts, 15 candidate metabolites were identified for liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS) quantifi

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Kot, Marta, Monika Baj-Krzyworzeka, Rafał Szatanek, Aleksandra Musiał-Wysocka, Magdalena Suda-Szczurek, and Marcin Majka. "The Importance of HLA Assessment in “Off-the-Shelf” Allogeneic Mesenchymal Stem Cells Based-Therapies." International Journal of Molecular Sciences 20, no. 22 (2019): 5680. http://dx.doi.org/10.3390/ijms20225680.

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The need for more effective therapies of chronic and acute diseases has led to the attempts of developing more adequate and less invasive treatment methods. Regenerative medicine relies mainly on the therapeutic potential of stem cells. Mesenchymal stem cells (MSCs), due to their immunosuppressive properties and tissue repair abilities, seem to be an ideal tool for cell-based therapies. Taking into account all available sources of MSCs, perinatal tissues become an attractive source of allogeneic MSCs. The allogeneic MSCs provide “off-the-shelf” cellular therapy, however, their allogenicity may

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Alansari, H., K. V. Brock, and L. N. D. Potgieter. "Single and Double Polymerase Chain Reaction for Detection of Bovine Viral Diarrhea Virus in Tissue Culture and Sera." Journal of Veterinary Diagnostic Investigation 5, no. 2 (1993): 148–53. http://dx.doi.org/10.1177/104063879300500201.

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Bovine viral diarrhea virus (BVDV) is an ubiquitous pathogen of cattle and has been reported in other ruminants. It is also frequently present in laboratory and biological materials as an adventitious agent. This virus is difficult to detect in some specimens, especially in the presence of specific antibody and when the virus is present in low concentrations. In this paper, we describe a single polymerase chain reaction (PCR) to amplify virus sequences from infected cell culture and a nested double PCR to detect small concentrations of several virus strains in sera. Total cellular RNA was extr

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Kumar Pasupulati, Anil, P. Swathi Chitra, and G. Bhanuprakash Reddy. "Advanced glycation end products mediated cellular and molecular events in the pathology of diabetic nephropathy." Biomolecular Concepts 7, no. 5-6 (2016): 293–309. http://dx.doi.org/10.1515/bmc-2016-0021.

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AbstractDiabetic nephropathy (DN) is a major cause of morbidity and mortality in diabetic patients and a leading cause of end-stage renal disease (ESRD). Degenerative changes such as glomerular hypertrophy, hyperfiltration, widening of basement membranes, tubulointerstitial fibrosis, glomerulosclerosis and podocytopathy manifest in various degrees of proteinuria in DN. One of the key mechanisms implicated in the pathogenesis of DN is non-enzymatic glycation (NEG). NEG is the irreversible attachment of reducing sugars onto free amino groups of proteins by a series of events, which include the f

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Marques, F., L. Corte-Real, A. P. Alves de Matos, et al. "Intracellular distribution of antitumor Ru (II) compounds: The lysosome and the lysosomal enzymes as targets for anticancer metal-based drugs." Microscopy and Microanalysis 19, S4 (2013): 9–10. http://dx.doi.org/10.1017/s1431927613000664.

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The therapeutic usefulness of anticancer agents relies on their ability to kill cancer cells while sparing normal cells and tissues. Ruthenium complexes hold great potential as suitable alternative drugs to the current cisplatin in the treatment of cancer. Our approach in this field has been the study of organoruthenium complexes, [RuII(η5-Cp)] family, namely [RuII(η5-Cp)(bipy)(PPh3)]+ (PPh3 = triphenylphosphine; bipy = 2,2’-bipyridine), TM34. This compound was tested for antitumor activity against tumor cells representative of human cancer diseases. A large spectrum of activity was found, lar

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Woolschlager, J., and B. E. Rittmann. "Que mesurent les tests de CODB et de COA ?" Revue des sciences de l'eau 8, no. 3 (2005): 371–85. http://dx.doi.org/10.7202/705229ar.

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Un des objectifs de cette recherche est d'examiner les différences entre les resultats obtenus par les tests de dosage des matières organiques biodégradables (MOB). L'autre objectif est de déterminer comment les résultats peuvent correspondre à la valeur vraie de la MOB. L'étude a été menée en employant un mode le mathématique qui tient compte des principes cinétiques et stoechiométriques. Le tableau 1 présente les exemples des équations de bilan de masse qui entrent dans le modèle. Celui-ci permet de suivre la croissance de la biomasse, la dégradation du substrat (MOB), le carbone organique d

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Vigani, Barbara, Caterina Valentino, Valeria Cavalloro, et al. "Gellan-Based Composite System as a Potential Tool for the Treatment of Nervous Tissue Injuries: Cross-Linked Electrospun Nanofibers Embedded in a RC-33-Loaded Freeze-Dried Matrix." Pharmaceutics 13, no. 2 (2021): 164. http://dx.doi.org/10.3390/pharmaceutics13020164.

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Injuries to the nervous system affect more than one billion people worldwide, and dramatically impact on the patient’s quality of life. The present work aimed to design and develop a gellan gum (GG)-based composite system for the local delivery of the neuroprotective sigma-1 receptor agonist, 1-[3-(1,1′-biphen)-4-yl] butylpiperidine (RC-33), as a potential tool for the treatment of tissue nervous injuries. The system, consisting of cross-linked electrospun nanofibers embedded in a RC-33-loaded freeze-dried matrix, was designed to bridge the lesion gap, control drug delivery and enhance axonal

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Wong, Catalina, Elisabeth Inman, Reiner Spaethe, and Sam Helgerson. "Fibrin-based biomaterials to deliver human growth factors." Thrombosis and Haemostasis 89, no. 03 (2003): 573–82. http://dx.doi.org/10.1055/s-0037-1613389.

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SummaryFibrin-based biomaterial preparations can be used as provisional growth matrices for cells important in tissue repair during wound healing in vivo. Their efficacy can be enhanced by including bioactive agents that promote specific cellular responses. This study examined the controlled delivery of the angiogenic growth factors bFGF, VEGF165, and VEGF121 using biomatrix preparations prepared from Fibrin Sealant product components. The growth factors were added prior to formation of the Fibrin Sealant clots, and the release kinetics of the proteins from the clots measured. The results indi

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VITTORELLI, Anne, Catherine GAUTHIER, Christian MICHOUDET, Guy MARTIN, and Gabriel BAVEREL. "Characteristics of glutamine metabolism in human precision-cut kidney slices: a 13C-NMR study." Biochemical Journal 387, no. 3 (2005): 825–34. http://dx.doi.org/10.1042/bj20041309.

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The metabolism of glutamine, a physiological substrate of the human kidney, plays a major role in systemic acid–base homoeostasis. Not only because of the limited availability of human renal tissue but also in part due to the lack of adequate cellular models, the mechanisms regulating the renal metabolism of this amino acid in humans have been poorly characterized. Therefore given the renewed interest in their use, human precision-cut renal cortical slices were incubated in Krebs–Henseleit medium (118 mM NaCl, 4.7 mM KCl, 1.18 mM KH2PO4, 1.18 mM MgSO4·7H2O, 24.9 mM NaHCO3 and 2.5 mM CaCl2·2H2O

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Robbins, P. F., M. El-Gamil, Y. F. Li, et al. "A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes." Journal of Experimental Medicine 183, no. 3 (1996): 1185–92. http://dx.doi.org/10.1084/jem.183.3.1185.

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A number of antigens recognized by tumor-reactive T cells have recently been identified. The antigens identified in mouse model systems appear, with one exception, to represent the products of mutated genes. In contrast, most of the antigens recognized by human tumor-reactive T cells reported to date appear to represent the products of non-mutated genes. Here we report the isolation of a cDNA clone encoding beta-catenin, which was shown to be recognized by the tumor-infiltrating lymphocyte (TIL) 1290, a HLA-A24 restricted melanoma-specific CTL line from patient 888. The cDNA clone, which was i

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Wang, Xiuli, Wen-Chung Chang, ChingLam W. Wong, et al. "An Engineered Cell Surface Polypeptide for Selection, Tracking and Ablation of Genetically Modified Hematopoietically Derived Cells Based on Human EGFR." Blood 116, no. 21 (2010): 1469. http://dx.doi.org/10.1182/blood.v116.21.1469.1469.

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Abstract Abstract 1469 Hematopoietic cell-based therapies, including genetically manipulated cell products derived from either hematopoietic stem cells or T cells, is an emerging area in applied biotechnology. In both of these venues, a variety of genetic engineering approaches are being studied to endow cells with novel attributes, to increase their therapeutic potency and/or safety. Common to the field of ex vivo cellular genetic engineering is the need to purify cells that express desired quantities of therapeutic transgene(s) and cull out non-expressing cells that either lack transgene end

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BAME, Karen J., Alan HASSALL, Crystal SANDERSON, Indumati VENKATESAN, and Chao SUN. "Partial purification of heparanase activities in Chinese hamster ovary cells: evidence for multiple intracellular heparanases." Biochemical Journal 336, no. 1 (1998): 191–200. http://dx.doi.org/10.1042/bj3360191.

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Heparanases are mammalian endoglycosidases that cleave heparan sulphate glycosaminoglycans from proteoglycan core proteins and degrade them into shorter chains. The enzymes have been proposed to act in a variety of cellular processes, including proteoglycan catabolism, remodelling of basement membranes and release of heparan sulphate-binding ligands from their extracellular storage sites. Additional functions for heparanases may be to generate short heparan sulphate chains that stabilize or activate other proteins. While heparanase activities have been described in a number of tissues and cell

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Shin, Myung-Geun, Hyeoung-Joon Kim, Hye-Ran Kim, et al. "Mitochondrial Genome Instability in AML Is Associated with Reduction in the Mitochondrial Replication." Blood 106, no. 11 (2005): 2754. http://dx.doi.org/10.1182/blood.v106.11.2754.2754.

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Abstract Genetic changes in mitochondrial DNA (mtDNA) have been hypothesized more widely to play important roles in senescence, autoimmune disease and malignancy because of a paucity of introns and limited repair mechanisms. Malfunction of mismatch repair genes produces genome instability which plays an important role in the development of human cancers. The mtDNA markers for mitochondrial genome instability (mtGI) were point mutations, insertions, deletions and length changes in homopolymeric nucleotide tracts. We investigated the mtGI in AML cells and its effect to alteration in mtDNA copy n

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Garcia-Martinez, V., C. Lopez Sanchez, W. Hamed, et al. "Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; focus on the nitric oxide pathwayAging395Heart failure with preserved ejection fraction develops when feeding western diet to senescence-accelerated mice396Cardiovascular markers as predictors of cognitive decline in elderly hypertensive patients397Changes in connexin43 in old rats with volume overload chronic heart failureGenetics and epigenetics400Calcium content in the aortic valve is associated with 1G>2G matrix metalloproteinase 1 polymorphism401Neuropeptide receptor gene s (NPSR1) polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community participantsGenomics, proteomics, metabolomics, lipidomics and glycomics405Gene expression quantification using multiplexed color-coded probe pairs to determine RNA content in sporadic cardiac myxoma406Large-scale phosphorylation study of the type 2 diabetic heart subjected to ischemia / reperfusion injury407Transcriptome-based identification of new anti-inflammatory properties of the olive oil hydroxytyrosol in vascular endothelial cell under basal and proinflammatory conditions408Gene polymorphisms combinations and risk of myocardial infarctionComputer modelling, bioinformatics and big data411Comparison of the repolarization reserve in three state-of-the-art models of the human ventricular action potentialMetabolism, diabetes mellitus and obesity414Endothelial monocyte-activating polypeptide-II improves heart function in type -I Diabetes mellitus415Admission glucose level is independent predictor of impaired left ventricular function in patients with acute myocardial infarction: a two dimensional speckle-tracking echocardiography study416Association between biochemical markers of lipid profile and inflammatory reaction and stiffness of the vascular wall in hypertensive patients with abdominal obesity417Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening418Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity419Statins in the treatment of non-alcoholic steatohepatitis (NASH). Our experience from a 2-year prospective study in Constanta County, Romania420Epicardial adipose tissue as a predictor of cardiovascular outcome in patients with ACS undergoing PCI?Arterial and pulmonary hypertension423Dependence between heart rhythm disorers and ID polymorphism of ACE gene in hypertensive patients424Molecular mechanisms underlying the beneficial effects of Urocortin 2 in pulmonary arterial hypertension425Inhibition of TGf-b axis and action of renin-angiotensin system in human ascending aorta aneurysms426Early signs of microcirculation and macrocirculation abnormalities in prehypertension427Vascular smooth muscle cell-expressed Tie-2 controls vascular tone428Cardiac and vascular remodelling in the development of chronic thrombo-embolic pulmonary hypertension in a novel swine modelBiomarkers431Arrhythmogenic cardiomyopathy: a new, non invasive biomarker432Can circulating microRNAs distinguish type 1 and type 2 myocardial infarction?433Design of a high-throughput multiplex proteomics assay to identify left ventricular diastolic dysfunction in diabetes434Monocyte-derived and P-selectin-carrying microparticles are differently modified by a low fat diet in patients with cardiovascular risk factors who will and who will not develop a cardiovascular event435Red blood cell distribution width assessment by polychromatic interference microscopy of thin films in chronic heart failure436Invasive and noninvasive evaluation of quality of radiofrequency-induced cardiac denervation in patients with atrial fibrillation437The effect of therapeutic hypothermia on the level of brain derived neurotrophic factor (BDNF) in sera following cardiopulmonary resustitation438Novel biomarkers to predict outcome in patients with heart failure and severe aortic stenosis439Biological factors linking depression and anxiety to cardiovascular disease440Troponins and myoglobin dynamic at coronary arteries graftingInvasive, non-invasive and molecular imaging443Diet composition effects on the genetic typing of the mouse ob mutation: a micro-ultrasound characterization of cardiac function, macro and micro circulation and liver steatosis444Characterization of pig coronary and rabbit aortic lesions using IV-OCT quantitative analysis: correlations with histologyGene therapy and cell therapy447Enhancing the survival and angiogenic potential of mouse atrial mesenchymal cells448VCAM-1 expression in experimental myocardial infarction and its relation to bone marrow-derived mononuclear cell retentionTissue engineering451Advanced multi layered scaffold that increases the maturity of stem cell-derived human cardiomyocytes452Response of engineered heart tissue to simulated ischemia/reperfusion in the presence of acute hyperglycemic conditions453Serum albumin hydrogels prevent de-differentiation of neonatal cardiomyocytes454A novel paintbrush technique for transfer of low viscosity ultraviolet light curable cyan methacrylate on saline immersed in-vitro sheep heart." Cardiovascular Research 111, suppl 1 (2016): S56—S81. http://dx.doi.org/10.1093/cvr/cvw149.

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Doyle, Timothy James. "Using Aptamer-Nanoparticle Bioconjugates For Imaging and Treating Prostate Cancer." Journal of Student Science and Technology 8, no. 2 (2015). http://dx.doi.org/10.13034/jsst.v8i2.63.

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Prostate cancer diagnoses increase each year, and current treatment strategies cause disturbing levels of serious side effects. This has necessitated a search for new strategies to employ more targeted treatments for malignant tissues. One promising alternative therapy is the use of a chemotherapeutic-nanoparticle-aptamer bioconjugate. This method employs aptamers which target over-expressed proteins on cancerous cell surfaces and bind to individual prostate tumour cells with incredible affinity. Once bound, the bioconjugate is taken into the cell where it delivers a toxic payload of chemother

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Bastin, Georges. "Quantitative analysis of metabolic networks and design of minimal bioreaction models." Revue Africaine de la Recherche en Informatique et Mathématiques Appliquées Volume 9, 2007 Conference in... (August 15, 2008). http://dx.doi.org/10.46298/arima.1891.

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International audience This tutorial paper is concerned with the design of macroscopic bioreaction models on the basis a quantitative analysis of the underlying cell metabolism. The paper starts with a review of two fundamental algebraic techniques for the quantitative analysis of metabolic networks : (i) the decomposition of complex metabolic networks into elementary pathways (or elementary modes), (ii) the metabolic flux analysis which aims at computing the entire intracellular flux distribution from a limited number of flux meaurements. Then it is discussed how these two fundamental techniq

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DUCROT, C., J. CHARLEY-POULAIN, and J. M. AYNAUD. "Numéro hors série 2004 : Encéphalopathies spongiformes transmissibles animales -Sommaire et avant-propos." INRAE Productions Animales 17, HS (2004). http://dx.doi.org/10.20870/productions-animales.2004.17.hs.3612.

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Ce numéro hors-série est consacré aux travaux sur les maladies à prions des animaux de ferme, menés à l’Inra en collaboration avec de nombreux organismes nationaux et internationaux. Il aborde de nombreuses facettes de la recherche sur ces agents et les maladies qu’ils occasionnent, tant sur le modèle tremblante que sur l’Encéphalopathie Spongiforme Bovine (ESB) : biologie de l’agent pathogène et notion de souche de prion, pathogénie de la maladie et résistance génétique, voies de transmission et évolution dans les populations animales, lutte contre les EST. Le premier article présente l

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Laxman, Kandala, B. Pradeep K. Reddy, Sumit K. Mishra, et al. "Bioinspired carrier-free peptide conjugated BF2-oxasmaragdyrin dye-based nano self-assemblies: a photostable NIR cancer theragnostic agent." NPG Asia Materials 12, no. 1 (2020). http://dx.doi.org/10.1038/s41427-020-00256-x.

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AbstractPhotothermal therapy (PTT) has attracted great interest in cancer treatment, and the quest for potential organic photothermal agents is underway owing to the nonbiodegradable nature and chronic toxicity of existing inorganic nanomaterials. Organic material-based nanoformulations with good photothermal and fluorescence properties in the near-infrared (NIR-I) window are scarce. However, porphyrins are one category of biocompatible systems that are advantageous for photothermal therapy but are currently based in the visible region, causing limited depth of tissue penetration and leading t

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Apple, Jacki. "Some Speculation on the Future of the Body and Soul." M/C Journal 2, no. 9 (2000). http://dx.doi.org/10.5204/mcj.1821.

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It's the beginning of 2000 and the 21st century is all mapped out. Since we've just had that time at the end of a decade (not to mention the end of the century, as well as the Christian calendar "millennium"), when all the pundits came out to review where we had been and forecast where we are going, we should have expected a profundity of future-casting. But neither the familiar prognostications of the coming apocalypse spewing forth from the Religious Right, nor the usual statistical projections made by "experts" on such things as population growth, world politics, economic cycles, new produc

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