Academic literature on the topic 'Produits biologiques – usage thérapeutique'
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Journal articles on the topic "Produits biologiques – usage thérapeutique":
Folléa, G., and J. P. Cazenave. "Produits dérivés du plasma : des produits biologiques à effet thérapeutique." Transfusion Clinique et Biologique 4, no. 2 (January 1997): 227–40. http://dx.doi.org/10.1016/s1246-7820(97)80086-9.
Larbouret, Christel, Marie-Alix Poul, and Thierry Chardès. "Imiter la réponse immunitaire humorale polyclonale." médecine/sciences 35, no. 12 (December 2019): 1083–91. http://dx.doi.org/10.1051/medsci/2019216.
Aouadi, Nawel, Francis Macary, and Adeline Alonso Ugaglia. "Évaluation multicritère des performances socio-économiques et environnementales de systèmes viticoles et de scénarios de transition agroécologique." Cahiers Agricultures 29 (2020): 19. http://dx.doi.org/10.1051/cagri/2020016.
Adebowale, Oluwawemimo O., Olanike K. Adeyemo, Olajoju Awoyomi, Racheal Dada, and Oluseyi Adebowale. "Antibiotic use and practices in commercial poultry laying hens in Ogun State Nigeria." Revue d’élevage et de médecine vétérinaire des pays tropicaux 69, no. 1 (July 4, 2016): 41. http://dx.doi.org/10.19182/remvt.31170.
Jdidia, Imene Ben, Kaouther Zribi, Meriam Boubaker, Amira Brahem, Mouna Sayadi, Marwa Tlijani, Zahra Saidani, and Amani Cherif. "Les médicaments qui interfèrent avec les bilans biologiques : revue de la littérature." Canadian Journal of Hospital Pharmacy 74, no. 4 (September 28, 2021). http://dx.doi.org/10.4212/cjhp.v74i4.3200.
Dissertations / Theses on the topic "Produits biologiques – usage thérapeutique":
Meunier, Thomas. "Étude des mécanismes d’action de nouveaux inhibiteurs de coronavirus humains." Thesis, Université de Lille (2018-2021), 2021. http://www.theses.fr/2021LILUS057.
Coronaviruses are enveloped RNA viruses infecting mammals and birds. Four coronaviruses causing mild diseases, like common cold, have been described in human, HCoV-OC43, HCoV-229E, HCoV-NL63 and HCoV-HKU1. During the last two decades, three new, highly pathogenic coronaviruses have been identified the SARS-CoV (Severe Acute Respiratory Syndrom) in 2003, the MERS-CoV (Middle East Respiratory Syndrome) in 2012 and recently the SARS-CoV-2 in December 2019. The COVID-19 global outbreak caused by SARS-CoV-2, highlighted the lack of specific antiviral available against this family of virus. The team of Dr Karin SERON from the Cellular and Molecular Virology laboratory of the Center for Infection and Immunity of Lille, is specialized in the identification of antiviral compounds from natural origin. Indeed, plants are a source of natural therapeutic compounds and many plants are still being used in traditional medicine. The aim of my thesis was to identify natural antiviral agents against highly pathogenic human coronaviruses with the help of the knowledge and tools developed by the laboratory. My first project was carried out in collaboration with the group of Dr Simon Bordage from the Pharmacognosy laboratory of the Faculty of Pharmacy of Lille directed by Pr Sevser Sahpaz. Plant extracts from Ivorian plants used it traditional medicine were tested against the coronavirus HCoV-229E and we selected the most active, the Mallotus oppositifollius extract. After bio-guided fractionation, the active compound was isolated and characterized, the pheophorbide a (Pba). Pba is able to inhibit the infection of HCoV-229E and highly pathogenic coronaviruses MERS-CoV and SARS-CoV-2 (IC50 = 0.18 μM) as well as other enveloped viruses using a photo-dynamic inactivation mechanism. Pba targets the viral envelop and inhibits the fusion step. Pba is the first described natural antiviral against SARS-CoV-2 with direct photosensitive virucidal activity. This molecule could potentially be used in therapy or as disinfectant. My second project was about an anthocyanidin, the delphinidin, identified in the laboratory for its antiviral activity against hepatitis C virus. We showed that delphinidin is an entry inhibitor of coronaviruses in a dose-dependent manner for HCoV-229E, MERS-CoV and SARS-CoV-2 (IC50 = 16-20 μM). Our results show that delphinidin targets the glycosylation sites on the surface protein S. Thanks to a collaboration with the laboratory of Medicinal and Bioorganic Chemistry of Strasbourg, led by Dr Mourad Elhabiri, delphinidin synthetic derivates were screened in order to identify compounds with higher antiviral capacities. We thereby identify an active compound against HCoV-229E with a lower IC50 than delphinidin (IC50 = 0.06 μM). Surprisingly, its mechanism of action seems to be different than delphinidin with an activity at the replication step.In conclusion, during my thesis I was able to identify new natural antivirals against human coronaviruses, and in particular SARS-CoV-2, with novel mechanisms of action. This work may serve as a basis for obtaining molecules that can be used in the future for the treatment of coronavirus diseases
Caporiccio, Bertrand. "Recherche sur quelques activités biologiques d'un polysaccharide sulfate acide : extrait et caractérisé chez une algue marine Asparagopsis armata (Rhodophycee, Bonnemaisoniale)." Perpignan, 1994. http://www.theses.fr/1994PERP0185.
Nyitchokeu-Biamou, Alain Didelle. "La consommation des produits sanguins à l'hôpital de Marmande." Bordeaux 2, 1998. http://www.theses.fr/1998BOR2M042.
Vassas-Jardel, Aude. "Activités biologiques d'organismes marins par tests moléculaires in vitro : étude particulière de corallistes undulatus et aplidium longithorax." Montpellier 1, 1996. http://www.theses.fr/1996MON13522.
Levy, Michaël. "Nanostructures magnétiques pour le diagnostic et la thérapie : hyperthermie, relaxation magnétique et devenir dans l'organisme." Paris 7, 2011. http://www.theses.fr/2011PA077033.
This thesis sets itself into the field of research and optimization of medical applications using magnetic nano-objects. The first part describes an application called magnetic hyperthermia. It consists in using nanopar-ticles as local heating mediators, submitting them to a high frequency magnetic field. After recalling the hyperthermia mechanisms as well as the associated therapeutic constraints, we report a study on different kinds of nanoparticles and other more complex Systems. The second part is focused on MRI contrast agent properties of magnetic nanoparticles. We present the role of nanoparticles in this diagnostic technique and the relaxation mechanisms they induce. The longitudinal relaxation time T1 is theoretically evaluated and compared with experiments. At last, we investigate the cellular internalization effect on the time T1. The last part focuses on the evolution of magnetic nanoparticles injected in the organism. We first investigate their long term in vivo biotransformation (using different magnetic methods to follow their evolution) and then, we consider the impact of cellular metabolism on their magnetic properties
Vidal, Jean-Sébastien. "Etude pharmacoépidémiologique du traitement de la démence en pratique médicale réelle : Analyse de l'utilisation de la mémantine à partir des données de la Caisse Nationale de l'Assurance Maladie des Travailleurs salariés." Paris 11, 2009. http://www.theses.fr/2009PA11T056.
Seyssel, Marc de. "Développement et transfert technologique de procédés chromatographiques destinés à la préparation de composés biologiques à usage thérapeutique : exemples de purification du facteur VIII et de l'immunoépuration du LDL-cholestérol." Nancy 1, 1992. http://docnum.univ-lorraine.fr/public/SCD_T_1992_0424_SEYSSEL.pdf.
Nguyen, Thi Huyen Tram. "Handling data below the quantification limit in viral kinetic modeling for model evaluation and prediction of treatment outcome." Paris 7, 2014. http://www.theses.fr/2014PA077224.
Viral kinetic (VK) models are useful tools to understand the lifecycle of hepatitis C virus and the mechanisms of action of antiviral agents. The understanding of virologic response can be improved by including pharmacokinetic (PK) information. VK model might also be useful to predict individual treatment outcome and support treatment personalization. One common problem in VK modeling is data below the quantification limit (BQL). However the impact of these data on model evaluation and treatment response prediction and how to properly handle them in these steps are still in question. We extended prediction discrepancies (pd) and normalized prediction distribution errors (npde) to handle BQL data and evaluated them in a simulation study. The extended metrics have better performance with satisfactory type I errors and powers, compared to the methods omitting BQL data. We developed a PK-VK model to characterize the VK to alisporivir, a cyclophillin inhibitor, given in with or without peg-IFN. The model provided good predictions for the virologic responses (BQL data fraction and SVR rate) for different combinations and doses of alisporivir in another study. We also studied by simulation the use of VK model to predict individual treatment outcome and evaluated several factors that can impact this prediction: methods for handling BQL data, design and a priori information on population parameters. We showed that Bayesian estimation of individual parameters can give good predictions for treatment outcome from only few early responses, provided that BQL data are correctly handled and correct a,priori information is available
Barbat, Aline. "Extraction, caractérisation chimique et valorisation biologique de glucuronoxylanes de bois de châtaignier : développement de nouveaux procédés de délignification." Limoges, 2009. http://aurore.unilim.fr/theses/nxfile/default/22be5a91-4656-419b-b6cd-5a9f0d8a8fbb/blobholder:0/2009LIMO4016.pdf.
Chestnut sawdust is rich in polysaccharides of industrial interest, including xylans. Experimental procedures for the extraction of these molecules usually make use of aggressive chemical treatments that hamper their large scale valorization. In a context of Green Chemistry, several chemical and biochemical delignification processes of chestnut sawdust have been developed, followed by water-extraction of xylans. Enzymatic delignification by laccases was found disappointing contrary to protocols taking advantage of radical reactions generated by phthalocyanine or iron porphyrin in presence of hydrogen peroxide. Characterization of the chemical structure along with studies of antitumoural properties led us to find a structure-activity relationship for a 4-O-methylglucuronoxylan from chestnut tree
Gallet, Sébastien. "Conception, synthèse et évaluation pharmacologique de thiadiazépines et oxathiazépines potentiellement anticancéreuses." Lille 2, 2003. http://www.theses.fr/2003LIL2P002.
Books on the topic "Produits biologiques – usage thérapeutique":
S, Osborne E. G., Glosser G. W, International Office of Epizootics, and International Symposium on Risk Assessment for Veterinary Biologicals: the Next Step in International Harmonisation, (1st : 1994 : Arlington, VA.), eds. Risk assessment for veterinary biologicals =: L'évaluation des risques appliquée aux produits biologiques à usage vétérinaire = La evaluaciónde riesgos aplicada a los productos biológicos de uso veterinario. Paris: Office International des Épizooties, 1995.