Relevant bibliographies by topics / Profiline 2A

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Profiline 2A'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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Journal articles on the topic "Profiline 2A"

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Sáenz, Amets, Margarita Azpitarte, Rubén Armañanzas, France Leturcq, Ainhoa Alzualde, Iñaki Inza, Federico García-Bragado, et al. "Gene Expression Profiling in Limb-Girdle Muscular Dystrophy 2A." PLoS ONE 3, no. 11 (November 18, 2008): e3750. http://dx.doi.org/10.1371/journal.pone.0003750.

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Haikarainen, Teemu, Wei-Qiang Chen, Gert Lubec, and Petri Kursula. "Structure, modifications and ligand-binding properties of rat profilin 2a." Acta Crystallographica Section D Biological Crystallography 65, no. 4 (March 19, 2009): 303–11. http://dx.doi.org/10.1107/s0907444909000699.

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Lam, Angela M., Christine Espiritu, Shalini Bansal, Holly M. Micolochick Steuer, Congrong Niu, Veronique Zennou, Meg Keilman, et al. "Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus." Antimicrobial Agents and Chemotherapy 56, no. 6 (March 19, 2012): 3359–68. http://dx.doi.org/10.1128/aac.00054-12.

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ABSTRACTPSI-7977, a prodrug of 2′-F-2′-C-methyluridine monophosphate, is the purified diastereoisomer of PSI-7851 and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. In this study, we profiled the activity of PSI-7977 and its ability to select for resistance using a number of different replicon cells. Results showed that PSI-7977 was active against genotype (GT) 1a, 1b, and 2a (strain JFH-1) replicons and chimeric replicons containing GT 2a (strain J6), 2b, and 3a NS5B polymerase. Cross-resistance studies using GT 1b replicons confirmed that the S282T change conferred resistance to PSI-7977. Subsequently, we evaluated the ability of PSI-7977 to select for resistance using GT 1a, 1b, and 2a (JFH-1) replicon cells. S282T was the common mutation selected among all three genotypes, but while it conferred resistance to PSI-7977 in GT 1a and 1b, JFH-1 GT 2a S282T showed only a very modest shift in 50% effective concentration (EC50) for PSI-7977. Sequence analysis of the JFH-1 NS5B region indicated that additional amino acid changes were selected both prior to and after the emergence of S282T. These include T179A, M289L, I293L, M434T, and H479P. Residues 179, 289, and 293 are located within the finger and palm domains, while 434 and 479 are located on the surface of the thumb domain. Data from the JFH-1 replicon variants showed that amino acid changes within the finger and palm domains together with S282T were required to confer resistance to PSI-7977, while the mutations on the thumb domain serve to enhance the replication capacity of the S282T replicons.
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Fan, Xu-Xu, Yuan Gao, Long Shu, Yan-Quan Wei, Xue-Ping Yao, Sui-Zhong Cao, Guang-Neng Peng, Xiang-Tao Liu, and Shi-Qi Sun. "Transcriptome profiling indicating canine parvovirus type 2a as a potential immune activator." Virus Genes 52, no. 6 (June 23, 2016): 768–79. http://dx.doi.org/10.1007/s11262-016-1363-5.

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Kiviniemi, Anu, Petri Heinonen, and Harri Lönnberg. "Oligonucleotides bearing pentaerythritol-derived mass tags." Open Chemistry 5, no. 1 (March 1, 2007): 191–200. http://dx.doi.org/10.2478/s11532-006-0046-9.

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AbstractFive different di-O-alkylated pentaerythritol phosphoramidite building blocks (2a–e) were synthesized and introduced into oligonucleotides to obtain mass-tagged probes (6a–f) useful in RNA transcription profiling. These non-nucleosidic mass tags allow categorization of oligonucleotide probes having identical nucleoside content and, hence, identification of the probe hybridized to RNA by mass spectrometry analysis. Hybridization properties of the oligonucleotide conjugates were elucidated by melting temperature measurements.
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Murk, K., S. Buchmeier, B. M. Jockusch, and M. Rothkegel. "In birds, profilin-2a is ubiquitously expressed and contributes to actin-based motility." Journal of Cell Science 122, no. 7 (March 3, 2009): 957–64. http://dx.doi.org/10.1242/jcs.041715.

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Keira, Yoko, Satoru Noguchi, Rumi Kurokawa, Masako Fujita, Narihiro Minami, Yukiko K. Hayashi, Takashi Kato, and Ichizo Nishino. "Characterization of lobulated fibers in limb girdle muscular dystrophy type 2A by gene expression profiling." Neuroscience Research 57, no. 4 (April 2007): 513–21. http://dx.doi.org/10.1016/j.neures.2006.12.010.

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Severino, Patricia, Olivier Dussurget, Ricardo Z. N. Vêncio, Emilie Dumas, Patricia Garrido, Gabriel Padilla, Pascal Piveteau, et al. "Comparative Transcriptome Analysis of Listeria monocytogenes Strains of the Two Major Lineages Reveals Differences in Virulence, Cell Wall, and Stress Response." Applied and Environmental Microbiology 73, no. 19 (August 17, 2007): 6078–88. http://dx.doi.org/10.1128/aem.02730-06.

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ABSTRACT Listeria monocytogenes is a food-borne, opportunistic, bacterial pathogen causing a wide spectrum of diseases, including meningitis, septicemia, abortion, and gastroenteritis, in humans and animals. Among the 13 L. monocytogenes serovars described, human listeriosis is mostly associated with strains of serovars 4b, 1/2b, and 1/2a. Within the species L. monocytogenes, three phylogenetic lineages are described. Serovar 1/2a belongs to phylogenetic lineage I, while serovars 4b and 1/2b group in phylogenetic lineage II. To explore the role of gene expression in the adaptation of L. monocytogenes strains of these two major lineages to different environments, as well as in virulence, we performed whole-genome expression profiling of six L. monocytogenes isolates of serovars 4b, 1/2b, and 1/2a of distinct origins, using a newly constructed Listeria multigenome DNA array. Comparison of the global gene expression profiles revealed differences among strains. The expression profiles of two strains having distinct 50% lethal doses, as assessed in the mouse model, were further analyzed. Gene ontology term enrichment analysis of the differentially expressed genes identified differences in protein-, nucleic acid-, carbon metabolism-, and virulence-related gene expression. Comparison of the expression profiles of the core genomes of all strains revealed differences between the two lineages with respect to cell wall synthesis, the stress-related sigma B regulon and virulence-related genes. These findings suggest different patterns of interaction with host cells and the environment, key factors for host colonization and survival in the environment.
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Chuck, Chi-Pang, Hak-Fun Chow, David Chi-Cheong Wan, and Kam-Bo Wong. "Profiling of Substrate Specificities of 3C-Like Proteases from Group 1, 2a, 2b, and 3 Coronaviruses." PLoS ONE 6, no. 11 (November 2, 2011): e27228. http://dx.doi.org/10.1371/journal.pone.0027228.

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Pauwels, Frederik, Wendy Mostmans, Ludo M. M. Quirynen, Liesbet van der Helm, Carlo W. Boutton, Anne-Stéphanie Rueff, Erna Cleiren, et al. "Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors." Journal of Virology 81, no. 13 (April 25, 2007): 6909–19. http://dx.doi.org/10.1128/jvi.01543-06.

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ABSTRACT The search for hepatitis C virus polymerase inhibitors has resulted in the identification of several nonnucleoside binding pockets. The shape and nature of these binding sites differ across and even within diverse hepatitis C virus genotypes. These differences confront antiviral drug discovery with the challenge of finding compounds that are capable of inhibition in variable binding pockets. To address this, we have established a hepatitis C virus mutant and genotypic recombinant polymerase panel as a means of guiding medicinal chemistry through the elucidation of the site of action of novel inhibitors and profiling against genotypes. Using a genotype 1b backbone, we demonstrate that the recombinant P495L, M423T, M414T, and S282T mutant enzymes can be used to identify the binding site of an acyl pyrrolidine analog. We assess the inhibitory activity of this analog and other nonnucleoside inhibitors with our panel of enzyme isolates generated from clinical sera representing genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a.
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Dissertations / Theses on the topic "Profiline 2A"

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Andriamoratsiresy, Dina. "Le récepteur de l’acide rétinoïque alpha (RAR-α) : nouveau rôle dans l’adhésion des fibroblastes." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ092/document.

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Les récepteurs de l’acide rétinoïque, RARα, β et γ sont des facteurs de transcription dépendants du ligand qui contrôlent l’expression de gènes spécifiques. Cependant, il s’avère depuis peu que les RAR ont aussi des effets non-transcriptionnels extranucléaires. Durant ma thèse, j’ai observé que (1) les fibroblastes invalidés pour tous les RAR ont un cytosquelette d’actine perturbé et ont perdu leurs propriétés d’adhésion (2) RARα interagit via son motif riche en proline N-terminal avec la profiline 2a (PFN2a) qui est un régulateur critique de l’élongation des filaments d’actine du cytosquelette. J’ai montré que : (1) Les RAR contrôlent la morphologie, l’adhésion et la migration des MEF via la régulation transcriptionnelle de l’expression de gènes codant pour des protéines d’adhésion (2) Dans le cytoplasme, RARα forme avec PFN2a des complexes dont le nombre contrôle le réseau d’actine et l’adhésion des MEF via un mécanisme non transcriptionnel. Ces observations mettent en exergue l’importance de la combinaison des effets génomiques et non-génomiques des RAR dans l’adhésion des cellules et ouvrent de nouvelles possibilités de dérégulation du fonctionnement des RAR dans certaines pathologies
Retinoic acid receptors, RARα, β and γ are ligand-dependent transcription factors that control the expression of specific genes. However, growing evidence indicates that RARs also have extranuclear and non transcriptional effects. During my thesis, I observed that (1) fibroblasts invalidated for all RARs depict a disrupted actin cytoskeleton and have lost their adhesion properties (2) RARα interacts through its N-terminal proline rich motif with profilin2a (PFN2a) a critical regulator of actin filaments elongation. I have shown that: (1) RARs control the morphology, adhesion and migration of MEFs via controlling at the transcriptional level the expression of adhesion genes (2) In the cytosol, RARα forms complexes with PFN2a. The number of these complexes controls the actin network and the adhesion of MEFs via a non-transcriptional mechanism. These observations highlight the importance of the combined genomic and non-genomic effects of RARs in cell adhesion, and open new avenues for RARs deregulations in certain pathology
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Murk, Kai Thomas [Verfasser]. "Analyse der funktionellen Diversität der Profilin-Isoformen 1 und 2a / von Kai Thomas Murk." 2008. http://d-nb.info/991999207/34.

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Book chapters on the topic "Profiline 2A"

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"This will be discussed later. Two species, Mansonia uniformis and Mansonia septempunctata, which breed in association with macrophytes such as water hyacinth Eichhornia crassipes, became less common from stage 1 to 2. The saltmarsh species Aedes vigilax was also collected in reasonable numbers at all localities around the reservoir. This species is known for its wide dispersal powers and was undoubtedly blown in from the extensive intertidal wetlands on the coast. Thus on the basis of abundance, two taxa – Culex annulirostris and Anopheles annulipes s.1. – warranted further consideration. The former species is considered to be the major vector of arboviruses in Australia (Russell 1995), transmitting Ross River, Barmah Forest, Kunjin, Kokobera, Alfuy and Edge Hill viruses and Murray Valley encephalitis, as well as dog heartworm. Of these, Ross River is by far the most common arbovirus in coastal northern Queensland, with morbidity approximating 400 cases per 100,000 population. Thus from first principles, this arbovirus and perhaps Barmah Forest, about which little is known, would constitute the greatest hazard to recreational use. Although Anopheles annulipes has previously been implicated in malaria transmission at Sellheim during the Second World War, this species group has returned isolated positives of Ross River and Barmah Forest viruses and Murray Valley encephalitis from other parts of Australia. However, no transmission studies have been done on the population from the reservoir. Thus on the evidence to date, it could not be regarded as a major concern at the Ross River dam. Both Culex annulirostris and Anopheles annulipes were shown to have seasonal peaks of abundance during the late post-wet season (March to May), with populations building up with the onset of spring (September to October). Spatially, the trapping programme was designed to compare mosquito numbers on the foreshore of the stage 1 lake with two localities expected to be on the margins of the stage 2A lake, with two remote localities (and therefore theoretically unaffected by any water resource project activity) as negative controls. Mosquito numbers (i.e. for those species known to breed at the dam) decreased with distance away from the Ross River dam. Both light trapping and human bait collections carried out twice per month were reasonable indicators of broad seasonal trends in mosquito abundance. However, the statistical analysis indicated that occasionally the light traps could miss short periods of high biting activity (Jones et al. 1991). If greater resolution was required, it was recommended that light traps could be supplemented with animal baited traps, although it is probable that this could be rectified by intensifying the light trapping regimen. Cluster analyses of dam breeding species in both 1984–85 and 1991–93 indicated that light trap catches along the northern (Big Bay, Ti-Tree Bay, Round Island) and western sides (Ross River) gave similar patterns, but the profile towards the east (Antill Creek, Toonpan, Oak Valley) was somewhat different (Barker-Hudson et al. 1993; Hearnden and Kay 1995). On this basis, adult mosquito surveillance would therefore need to be based on two localities at either end of the lake." In Water Resources, 143. CRC Press, 1998. http://dx.doi.org/10.4324/9780203027851-31.

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Conference papers on the topic "Profiline 2A"

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Błachut, J. "Buckling of Cylinders With Imperfect Length." In ASME 2013 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/pvp2013-97316.

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Eighteen mild steel cylinders with the length-to-radius ratio, L/R ≈ 2.4 and with the radius-to-wall thickness ratio, R/t ≈ 185 were collapsed by axial compression. Cylinders had variable length at one end of sinusoidal profile. The magnitude-to-wall thickness ratio, 2A/t, was varied between 0.05 and 1.0. Experimental results show that buckling strength strongly depends on the axial amplitude of imperfection. On average imperfect cylinders, with 2A/t = 1.0, are able to support 49 % of experimental buckling load obtained for geometrically perfect model. The largest sensitivity of buckling strength was associated with small amplitudes of axial length. For example, for axial length imperfection amounting to 25 % of wall thickness the buckling strength was reduced by 40 %. It appears that the number of sinusoidal waves in the imperfection profile plays a secondary role, i.e., its role in reducing the buckling strength is not a dominant factor. The paper provides experimental details and comparisons with numerical results.
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Niu, Jinlin, Lidong Wang, Jiong Guo, and Fu Li. "Development of Single Pebble Benchmark Ex. I-2A for IAEA UAM CRP With MOOSE." In 2018 26th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/icone26-82155.

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Ex. I-2a is Uncertainty Analysis in Modelling (UAM) of stand-alone thermal-hydraulics in steady state. It belongs to IAEA Coordinated Research Project (CRP). In this paper, the work is divided into two steps. Firstly, a single pebble model is developed based on Multiphysics Object Oriented Simulation Environment (MOOSE). The model includes two regions: homogeneous fuel region and shell region. One physical field is concerned: solid temperature field. The field is solved in a Jacobian-free Newton–Krylov (JFNK) way in the MOOSE framework. Secondly, perturbation of thermal parameters is done. In this paper, helium coolant temperature, convective heat transfer coefficient, power density and solid conductivity are the main thermal parameters which are concerned. Different kinds of perturbation of thermal parameters are conducted. Thus, variation of temperature profile across the pebble, Doppler temperature, moderator temperature and maximum temperature could be got.
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Hodkinson, Brendan, Michael Schaffer, Joshua Brody, Wojciech Jurczak, Cecilia Carpio, Dina Ben-Yehuda, Irit Avivi, et al. "Abstract 4024: Phase 1/2a LYM1002 study of ibrutinib (ibr) + nivolumab (nivo): Exome and gene expression profiling (GEP) analyses by histology and responder status." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-4024.

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Hodkinson, Brendan, Michael Schaffer, Joshua Brody, Wojciech Jurczak, Cecilia Carpio, Dina Ben-Yehuda, Irit Avivi, et al. "Abstract 4024: Phase 1/2a LYM1002 study of ibrutinib (ibr) + nivolumab (nivo): Exome and gene expression profiling (GEP) analyses by histology and responder status." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-4024.

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