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Journal articles on the topic 'Progenitor Fate'

Author: Grafiati

Published: 24 May 2025

Last updated: 31 July 2025

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1

Chen, Lipeng, Qing Sun, Jihao Zhou, et al. "New Insights into Hematopoietic Redefinition and New Paradigms in Hematopoietic Hierarchy Roadmap." Blood 142, Supplement 1 (2023): 4057. http://dx.doi.org/10.1182/blood-2023-173249.

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The definition of hematopoietic progenitor cells (HPCs) has not been standardized. Surface markers are insufficient to capture the entire differentiation stages of progenitor cells and reflect the dynamic differentiation mechanisms underlying hematopoiesis. Deciphering the hematopoiesis mechanism that underlies progenitor cells definition and fate decision are critical to understanding fundamental questions of hematopoietic lineage commitment. Here, we redefined the entire spectrum of adult hematopoietic progenitors, and recovered the critical transcript factors (TFs) in lineages fate decision

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2

Jagla, T., F. Bellard, Y. Lutz, G. Dretzen, M. Bellard, and K. Jagla. "ladybird determines cell fate decisions during diversification of Drosophila somatic muscles." Development 125, no. 18 (1998): 3699–708. http://dx.doi.org/10.1242/dev.125.18.3699.

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In the mesoderm of Drosophila embryos, a defined number of cells segregate as progenitors of individual body wall muscles. Progenitors and their progeny founder cells display lineage-specific expression of transcription factors but the mechanisms that regulate their unique identities are poorly understood. Here we show that the homeobox genes ladybird early and ladybird late are expressed in only one muscle progenitor and its progeny: the segmental border muscle founder cell and two precursors of adult muscles. The segregation of the ladybird-positive progenitor requires coordinate action of n

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3

Morrow, Theresa, Mi-Ryoung Song, and Anirvan Ghosh. "Sequential specification of neurons and glia by developmentally regulated extracellular factors." Development 128, no. 18 (2001): 3585–94. http://dx.doi.org/10.1242/dev.128.18.3585.

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Cortical progenitor cells give rise to neurons during embryonic development and to glia after birth. While lineage studies indicate that multipotent progenitor cells are capable of generating both neurons and glia, the role of extracellular signals in regulating the sequential differentiation of these cells is poorly understood. To investigate how factors in the developing cortex might influence cell fate, we developed a cortical slice overlay assay in which cortical progenitor cells are cultured over cortical slices from different developmental stages. We find that embryonic cortical progenit

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4

Yang, Yun, Hao Wang, Jia He, et al. "A single-cell–resolution fate map of endoderm reveals demarcation of pancreatic progenitors by cell cycle." Proceedings of the National Academy of Sciences 118, no. 25 (2021): e2025793118. http://dx.doi.org/10.1073/pnas.2025793118.

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A progenitor cell could generate a certain type or multiple types of descendant cells during embryonic development. To make all the descendant cell types and developmental trajectories of every single progenitor cell clear remains an ultimate goal in developmental biology. Characterizations of descendant cells produced by each uncommitted progenitor for a full germ layer represent a big step toward the goal. Here, we focus on early foregut endoderm, which generates foregut digestive organs, including the pancreas, liver, foregut, and ductal system, through distinct lineages. Using unbiased sin

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Yuan, Yuan, Yong-hwee Eddie Loh, Xia Han, et al. "Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis." Science Advances 6, no. 51 (2020): eabb0119. http://dx.doi.org/10.1126/sciadv.abb0119.

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Cranial neural crest (CNC) cells contribute to different cell types during embryonic development. It is unknown whether postmigratory CNC cells undergo dynamic cellular movement and how the process of cell fate decision occurs within the first pharyngeal arch (FPA). Our investigations demonstrate notable heterogeneity within the CNC cells, refine the patterning domains, and identify progenitor cells within the FPA. These progenitor cells undergo fate bifurcation that separates them into common progenitors and mesenchymal cells, which are characterized by Cdk1 and Spry2/Notch2 expression, respe

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6

Sánchez-González, Rebeca, María Figueres-Oñate, Ana Cristina Ojalvo-Sanz, and Laura López-Mascaraque. "Cell Progeny in the Olfactory Bulb after Targeting Specific Progenitors with Different UbC-StarTrack Approaches." Genes 11, no. 3 (2020): 305. http://dx.doi.org/10.3390/genes11030305.

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The large phenotypic variation in the olfactory bulb may be related to heterogeneity in the progenitor cells. Accordingly, the progeny of subventricular zone (SVZ) progenitor cells that are destined for the olfactory bulb is of particular interest, specifically as there are many facets of these progenitors and their molecular profiles remain unknown. Using modified StarTrack genetic tracing strategies, specific SVZ progenitor cells were targeted in E12 mice embryos, and the cell fate of these neural progenitors was determined in the adult olfactory bulb. This study defined the distribution and

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Desai, A. R., and S. K. McConnell. "Progressive restriction in fate potential by neural progenitors during cerebral cortical development." Development 127, no. 13 (2000): 2863–72. http://dx.doi.org/10.1242/dev.127.13.2863.

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During early stages of cerebral cortical development, progenitor cells in the ventricular zone are multipotent, producing neurons of many layers over successive cell divisions. The laminar fate of their progeny depends on environmental cues to which the cells respond prior to mitosis. By the end of neurogenesis, however, progenitors are lineally committed to producing upper-layer neurons. Here we assess the laminar fate potential of progenitors at a middle stage of cortical development. The progenitors of layer 4 neurons were first transplanted into older brains in which layer 2/3 was being ge

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8

Belliveau, M. J., and C. L. Cepko. "Extrinsic and intrinsic factors control the genesis of amacrine and cone cells in the rat retina." Development 126, no. 3 (1999): 555–66. http://dx.doi.org/10.1242/dev.126.3.555.

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The seven major classes of cells of the vertebrate neural retina are generated from a pool of multipotent progenitor cells. Recent studies suggest a model of retinal development in which both the progenitor cells and the environment change over time (Cepko, C. L., Austin, C. P., Yang, X., Alexiades, M. and Ezzeddine, D. (1996). Proc. Natl. Acad. Sci. USA 93, 589–595). We have utilized a reaggregate culture system to test this model. A labeled population of progenitors from the embryonic rat retina were cultured with an excess of postnatal retinal cells and then assayed for their cell fate choi

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9

Olmos-Carreño, Cindy L., María Figueres-Oñate, Gabriel E. Scicolone, and Laura López-Mascaraque. "Cell Fate of Retinal Progenitor Cells: In Ovo UbC-StarTrack Analysis." International Journal of Molecular Sciences 23, no. 20 (2022): 12388. http://dx.doi.org/10.3390/ijms232012388.

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Clonal cell analysis outlines the ontogenic potential of single progenitor cells, allowing the elucidation of the neural heterogeneity among different cell types and their lineages. In this work, we analyze the potency of retinal stem/progenitor cells through development using the chick embryo as a model. We implemented in ovo the clonal genetic tracing strategy UbC-StarTrack for tracking retinal cell lineages derived from individual progenitors of the ciliary margin at E3.5 (HH21-22). The clonal assignment of the derived-cell progeny was performed in the neural retina at E11.5-12 (HH38) throu

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10

Soukup, Alexandra, Kirby D. Johnson, Daniel J. Conn, et al. "GATA2-Dependent Developmental and Regenerative Networks." Blood 134, Supplement_1 (2019): 1182. http://dx.doi.org/10.1182/blood-2019-126875.

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Coding and regulatory human GATA2 mutations that deregulate protein expression and/or function cause immunodeficiency that often progresses to MDS/AML (McReynolds et al., 2018). In the mouse, decreased GATA2 expression impairs hematopoietic stem/progenitor cell (HSPC) genesis and function (de Pater et al., 2013; Gao et al., 2013; Tsai et al., 1994). While prior studies demonstrated Gata2 +9.5 and -77 enhancers are essential for HSC emergence (+9.5) and/or progenitor cell fate (+9.5 and -77) (Johnson et al., 2012; Johnson et al., 2015; Mehta et al., 2017) and hematopoietic regeneration (+9.5) (

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11

Zheng, Mingzhu, Chao Zhong, Kairong Cui, et al. "Quantitative Expression of GATA3 Specifies Lineage Fates and Functions of Innate Lymphoid Cells." Journal of Immunology 204, no. 1_Supplement (2020): 223.9. http://dx.doi.org/10.4049/jimmunol.204.supp.223.9.

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Abstract Innate lymphoid cells (ILCs) are the innate counterparts of the CD4 T helper cells of the adaptive system. While the CD4 T cell development and differentiation have been well studied, the development of ILC subsets is far from clear. Lymphoid tissue inducer (LTi) population is the founding member of ILCs, however, recent study has shown that these cells are not derived from a PLZF-expressing ILC common progenitor that generates other ILCs. The transcription factor(s) determining the fate of non-LTi progenitor versus LTi progenitor are unknown. Here we report that GATA3 is absolutely r

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Grover, Amit, Elena Mancini, Susan Moore, et al. "Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate." Journal of Experimental Medicine 211, no. 2 (2014): 181–88. http://dx.doi.org/10.1084/jem.20131189.

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The erythroid stress cytokine erythropoietin (Epo) supports the development of committed erythroid progenitors, but its ability to act on upstream, multipotent cells remains to be established. We observe that high systemic levels of Epo reprogram the transcriptomes of multi- and bipotent hematopoietic stem/progenitor cells in vivo. This induces erythroid lineage bias at all lineage bifurcations known to exist between hematopoietic stem cells (HSCs) and committed erythroid progenitors, leading to increased erythroid and decreased myeloid HSC output. Epo, therefore, has a lineage instructive rol

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13

Punzel, M., S. D. Wissink, J. S. Miller, K. A. Moore, I. R. Lemischka, and C. M. Verfaillie. "The Myeloid-Lymphoid Initiating Cell (ML-IC) Assay Assesses the Fate of Multipotent Human Progenitors In Vitro." Blood 93, no. 11 (1999): 3750–56. http://dx.doi.org/10.1182/blood.v93.11.3750.411a37_3750_3756.

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Hematopoietic stem cells (HSC) are cells with self-renewing multilineage differentiation potential. Although engraftment in xenogeneic recipients can be used to measure human HSC, these assays do not allow assessment of individual progenitors. We developed an in vitro assay that allows the identification of a single human bone marrow progenitor closely related to HSC, which we termed “Myeloid-Lymphoid Initiating Cell,” or ML-IC, because it is capable of generating multiple secondary progenitors that can reinitiate long-term myeloid and lymphoid hematopoiesis in vitro. The assay is done in cont

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14

Nakano, Saori, Akira Niwa, Yohko Kitagawa, Hidefumi Hiramatsu, and Megumu K. Saito. "IL-4 Acts at an Early Fate-Determining Junction in Hematopoiesis to Induce NK Cell Subsets Expressing Endogenous CD16." Blood 142, Supplement 1 (2023): 1. http://dx.doi.org/10.1182/blood-2023-188768.

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Human NK cells are known to contain subsets of CD56 +CD16 + and CD56 +CD16 - cells. The former directly attack target cells by an antibody-dependent cellular cytotoxicity (ADCC) various organs in the body, whereas the latter are mainly found in lymph nodes and activate inflammatory and immune responses by secreting IFNγ. However, despite their importance in the biological defence systems, whether and how these subsets emerge is not yet fully understood. In particular, several recent studies have challenged the conventional linear differentiation model which positioned CD56 +CD16 - cells as pro

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15

Petridou, Eleni, and Leanne Godinho. "Cellular and Molecular Determinants of Retinal Cell Fate." Annual Review of Vision Science 8, no. 1 (2022): 79–99. http://dx.doi.org/10.1146/annurev-vision-100820-103154.

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The vertebrate retina is regarded as a simple part of the central nervous system (CNS) and thus amenable to investigations of the determinants of cell fate. Its five neuronal cell classes and one glial cell class all derive from a common pool of progenitors. Here we review how each cell class is generated. Retinal progenitors progress through different competence states, in each of which they generate only a small repertoire of cell classes. The intrinsic state of the progenitor is determined by the complement of transcription factors it expresses. Thus, although progenitors are multipotent, t

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16

Punzel, M., S. D. Wissink, J. S. Miller, K. A. Moore, I. R. Lemischka, and C. M. Verfaillie. "The Myeloid-Lymphoid Initiating Cell (ML-IC) Assay Assesses the Fate of Multipotent Human Progenitors In Vitro." Blood 93, no. 11 (1999): 3750–56. http://dx.doi.org/10.1182/blood.v93.11.3750.

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Abstract Hematopoietic stem cells (HSC) are cells with self-renewing multilineage differentiation potential. Although engraftment in xenogeneic recipients can be used to measure human HSC, these assays do not allow assessment of individual progenitors. We developed an in vitro assay that allows the identification of a single human bone marrow progenitor closely related to HSC, which we termed “Myeloid-Lymphoid Initiating Cell,” or ML-IC, because it is capable of generating multiple secondary progenitors that can reinitiate long-term myeloid and lymphoid hematopoiesis in vitro. The assay is don

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17

Holmes, David. "PTH regulates bone marrow progenitor fate." Nature Reviews Endocrinology 13, no. 4 (2017): 190. http://dx.doi.org/10.1038/nrendo.2017.19.

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18

Bhattaram, Pallavi, Kenji Kato, and Véronique Lefebvre. "Progenitor cell fate, SOXC and WNT." Oncotarget 6, no. 28 (2015): 24596–97. http://dx.doi.org/10.18632/oncotarget.5237.

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19

KOURY, MARK J., LINDA L. KELLEY, and MAURICE C. BONDURANT. "The Fate of Erythroid Progenitor Cellsa." Annals of the New York Academy of Sciences 718, no. 1 (2008): 259–70. http://dx.doi.org/10.1111/j.1749-6632.1994.tb55725.x.

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20

Traver, David, Toshihiro Miyamoto, Julie Christensen, Junko Iwasaki-Arai, Koichi Akashi, and Irving L. Weissman. "Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets." Blood 98, no. 3 (2001): 627–35. http://dx.doi.org/10.1182/blood.v98.3.627.

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Abstract Hematopoietic fate maps in the developing mouse embryo remain imprecise. Definitive, adult-type hematopoiesis first appears in the fetal liver, then progresses to the spleen and bone marrow. Clonogenic common lymphoid progenitors and clonogenic common myeloid progenitors (CMPs) in adult mouse bone marrow that give rise to all lymphoid and myeloid lineages, respectively, have recently been identified. Here it is shown that myelopoiesis in the fetal liver similarly proceeds through a CMP equivalent. Fetal liver CMPs give rise to megakaryocyte–erythrocyte-restricted progenitors (MEPs) an

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21

Kharrat, Bayan, Erika Gábor, Nikolett Virág, et al. "Dual role for Headcase in hemocyte progenitor fate determination in Drosophila melanogaster." PLOS Genetics 20, no. 10 (2024): e1011448. http://dx.doi.org/10.1371/journal.pgen.1011448.

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The hematopoietic organ of the Drosophila larva, the lymph gland, is a simplified representation of mammalian hematopoietic compartments, with the presence of hemocyte progenitors in the medullary zone (MZ), differentiated hemocytes in the cortical zone (CZ), and a hematopoietic niche called the posterior signaling centre (PSC) that orchestrates progenitor differentiation. Our previous work has demonstrated that the imaginal cell factor Headcase (Hdc, Heca) is required in the hematopoietic niche to control the differentiation of hemocyte progenitors. However, the downstream mechanisms of Hdc-m

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22

Brown, Geoffrey, Rhodri Ceredig, and Panagiotis Tsapogas. "The Making of Hematopoiesis: Developmental Ancestry and Environmental Nurture." International Journal of Molecular Sciences 19, no. 7 (2018): 2122. http://dx.doi.org/10.3390/ijms19072122.

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Evidence from studies of the behaviour of stem and progenitor cells and of the influence of cytokines on their fate determination, has recently led to a revised view of the process by which hematopoietic stem cells and their progeny give rise to the many different types of blood and immune cells. The new scenario abandons the classical view of a rigidly demarcated lineage tree and replaces it with a much more continuum-like view of the spectrum of fate options open to hematopoietic stem cells and their progeny. This is in contrast to previous lineage diagrams, which envisaged stem cells progre

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Scanlon, Vanessa M., Maria Kochugaeva, Juliana Xavier-Ferrucio, et al. "Developing Single Cell Live Imaging Strategies to Determine MEP Fate and Predict Potential." Blood 134, Supplement_1 (2019): 1190. http://dx.doi.org/10.1182/blood-2019-131204.

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The molecular mechanisms underlying lineage commitment of stem and progenitor cells have implications for deriving specific cell types in vitro for regenerative medicine purposes and elucidating the aberrant pathways responsible for pathological conditions. We investigated Megakaryocytic-Erythroid Progenitors (MEP) commitment to the megakaryocytic (Mk) and erythroid (E) lineages as a model of cell fate decisions. Colony forming unit (CFU) assays are used to test the functional output, or lineage potential, of progenitor cell populations. As single progenitor cells proliferate, their progeny re

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Tung, James, Kristine Veys, Daryl Sembrano, Casey Hall, and Christian Ross. "Expression profiling of B-1 and B-2 progenitors (36.15)." Journal of Immunology 184, no. 1_Supplement (2010): 36.15. http://dx.doi.org/10.4049/jimmunol.184.supp.36.15.

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Abstract B-1 and B-2 comprise the two B cell lineages. B-1 and B-2 cells can be distinguished by their surface phenotype and also by their developmental ontology, immunoglobulin repertoire, anatomical localization, and immune functions. Importantly, B-1 cells arise early in fetal liver while B-2 cells are generated in the bone marrow after birth. The appearance of B-1 and B-2 cells is the result of fetal B-cell development versus adult B-cell development. B-1 and B-2 cells are generated from distinct progenitor cells, namely B-1 progenitors and B-2 progenitors. B-1 progenitors express CD19 but

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McConnell, SK, and CE Kaznowski. "Cell cycle dependence of laminar determination in developing neocortex." Science 254, no. 5029 (1991): 282–85. http://dx.doi.org/10.1126/science.254.5029.282.

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The neocortex is patterned in layers of neurons that are generated in an orderly sequence during development. This correlation between cell birthday and laminar fate prompted an examination of how neuronal phenotypes are determined in the developing cortex. At various times after labeling with [3H]thymidine, embryonic progenitor cells were transplanted into older host brains. The laminar fate of transplanted neurons correlates with the position of their progenitors in the cell cycle at the time of transplantation. Daughters of cells transplanted in S-phase migrate to layer 2/3, as do host neur

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Hong, Xinyi, Ning-Chen Sun, Zexi Niu, Junjie Wu, Qiang Xi, and Jifeng Liu. "Constraining the Progenitor of the Nearby Type II-P SN 2024ggi with Environmental Analysis." Astrophysical Journal Letters 977, no. 2 (2024): L50. https://doi.org/10.3847/2041-8213/ad99da.

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Abstract The progenitors of Type II-P supernovae (SN) have been confirmed to be red supergiants. However, the upper mass limit of the directly probed progenitors is much lower than that predicted by current theories, and the accurate determination of the progenitor masses is key to understand the final fate of massive stars. Located at a distance of only 6.72 Mpc, the Type II-P SN 2024ggi is one of the closest SNe in the last decade. Previous studies have analyzed its progenitor by direct detection, but the derived progenitor mass may be influenced by the very uncertain circumstellar extinctio

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Coffey, Francis, Sang-Yun Lee, Terkild B. Buus та ін. "The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification". Journal of Experimental Medicine 211, № 2 (2014): 329–43. http://dx.doi.org/10.1084/jem.20131540.

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Numerous studies indicate that γδ T cell receptor (γδTCR) expression alone does not reliably mark commitment of early thymic progenitors to the γδ fate. This raises the possibility that the γδTCR is unable to intrinsically specify fate and instead requires additional environmental factors, including TCR–ligand engagement. We use single cell progenitor assays to reveal that ligand acts instructionally to direct adoption of the γδ fate. Moreover, we identify CD73 as a TCR ligand-induced cell surface protein that distinguishes γδTCR-expressing CD4−CD8− progenitors that have committed to the γδ fa

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Benmimoun, Billel, Cédric Polesello, Marc Haenlin, and Lucas Waltzer. "The EBF transcription factor Collier directly promotes Drosophila blood cell progenitor maintenance independently of the niche." Proceedings of the National Academy of Sciences 112, no. 29 (2015): 9052–57. http://dx.doi.org/10.1073/pnas.1423967112.

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The maintenance of stem or progenitor cell fate relies on intrinsic factors as well as local cues from the cellular microenvironment and systemic signaling. In the lymph gland, an hematopoietic organ in Drosophila larva, a group of cells called the Posterior Signaling Centre (PSC), whose specification depends on the EBF transcription factor Collier (Col) and the HOX factor Antennapedia (Antp), has been proposed to form a niche required to maintain the pool of hematopoietic progenitors (prohemocytes). In contrast with this model, we show here that genetic ablation of the PSC does not cause an i

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Walasek, Marta A., Leonid Bystrykh, Vincent van den Boom, et al. "The combination of valproic acid and lithium delays hematopoietic stem/progenitor cell differentiation." Blood 119, no. 13 (2012): 3050–59. http://dx.doi.org/10.1182/blood-2011-08-375386.

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Abstract Despite increasing knowledge on the regulation of hematopoietic stem/progenitor cell (HSPC) self-renewal and differentiation, in vitro control of stem cell fate decisions has been difficult. The ability to inhibit HSPC commitment in culture may be of benefit to cell therapy protocols. Small molecules can serve as tools to manipulate cell fate decisions. Here, we tested 2 small molecules, valproic acid (VPA) and lithium (Li), to inhibit differentiation. HSPCs exposed to VPA and Li during differentiation-inducing culture preserved an immature cell phenotype, provided radioprotection to

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Ramesh, Parvathy, Satish Kumar Tiwari, Md Kaizer та ін. "The NF-κB Factor Relish maintains blood progenitor homeostasis in the developing Drosophila lymph gland". PLOS Genetics 20, № 9 (2024): e1011403. http://dx.doi.org/10.1371/journal.pgen.1011403.

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Post-larval hematopoiesis in Drosophila largely depends upon the stockpile of progenitors present in the blood-forming organ/lymph gland of the larvae. During larval stages, the lymph gland progenitors gradually accumulate reactive oxygen species (ROS), which is essential to prime them for differentiation. Studies have shown that ROS triggers the activation of JNK (c-Jun Kinase), which upregulates fatty acid oxidation (FAO) to facilitate progenitor differentiation. Intriguingly, despite having ROS, the entire progenitor pool does not differentiate simultaneously in the late larval stages. Usin

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Lian, Gewei, Timothy Wong, Jie Lu, Jianjun Hu, Jingping Zhang, and Volney Sheen. "Cytoskeletal Associated Filamin A and RhoA Affect Neural Progenitor Specification During Mitosis." Cerebral Cortex 29, no. 3 (2018): 1280–90. http://dx.doi.org/10.1093/cercor/bhy033.

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Abstract Neural progenitor proliferation and cell fate decision from self-renewal to differentiation are crucial factors in determining brain size and morphology. The cytoskeletal dependent regulation of these processes is not entirely known. The actin-binding filamin A (FlnA) was shown to regulate proliferation of progenitors by directing changes in cell cycles proteins such as Cdk1 during G2/M phase. Here we report that functional loss of FlnA not only affects the rate of proliferation by altering cell cycle length but also causes a defect in early differentiation through changes in cell fat

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Buza-Vidas, Natalija, Petter Woll, Anne Hultquist, et al. "FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells." Blood 118, no. 6 (2011): 1544–48. http://dx.doi.org/10.1182/blood-2010-10-316232.

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Abstract Lymphoid-primed multipotent progenitors with down-regulated megakaryocyte-erythroid (MkE) potential are restricted to cells with high levels of cell-surface FLT3 expression, whereas HSCs and MkE progenitors lack detectable cell-surface FLT3. These findings are compatible with FLT3 cell-surface expression not being detectable in the fully multipotent stem/progenitor cell compartment in mice. If so, this process could be distinct from human hematopoiesis, in which FLT3 already is expressed in multipotent stem/progenitor cells. The expression pattern of Flt3 (mRNA) and FLT3 (protein) in

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Andrews, Madeline G., and Caroline A. Pearson. "Toward an understanding of glucose metabolism in radial glial biology and brain development." Life Science Alliance 7, no. 1 (2023): e202302193. http://dx.doi.org/10.26508/lsa.202302193.

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Decades of research have sought to determine the intrinsic and extrinsic mechanisms underpinning the regulation of neural progenitor maintenance and differentiation. A series of precise temporal transitions within progenitor cell populations generates all the appropriate neural cell types while maintaining a pool of self-renewing progenitors throughout embryogenesis. Recent technological advances have enabled us to gain new insights at the single-cell level, revealing an interplay between metabolic state and developmental progression that impacts the timing of proliferation and neurogenesis. T

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Schweitzer, Ronen, Jay H. Chyung, Lewis C. Murtaugh, et al. "Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments." Development 128, no. 19 (2001): 3855–66. http://dx.doi.org/10.1242/dev.128.19.3855.

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Little is known about the genesis and patterning of tendons and other connective tissues, mostly owing to the absence of early markers. We have found that Scleraxis, a bHLH transcription factor, is a highly specific marker for all the connective tissues that mediate attachment of muscle to bone in chick and mouse, including the limb tendons, and show that early scleraxis expression marks the progenitor cell populations for these tissues. In the early limb bud, the tendon progenitor population is found in the superficial proximomedial mesenchyme. Using the scleraxis gene as a marker we show tha

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Farrar, J. David, Wenjun Ouyang, Max Löhning, et al. "An Instructive Component in T Helper Cell Type 2 (Th2) Development Mediated by Gata-3." Journal of Experimental Medicine 193, no. 5 (2001): 643–50. http://dx.doi.org/10.1084/jem.193.5.643.

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Although interleukin (IL)-12 and IL-4 polarize naive CD4+ T cells toward T helper cell type 1 (Th1) or Th2 phenotypes, it is not known whether cytokines instruct the developmental fate in uncommitted progenitors or select for outgrowth of cells that have stochastically committed to a particular fate. To distinguish these instructive and selective models, we used surface affinity matrix technology to isolate committed progenitors based on cytokine secretion phenotype and developed retroviral-based tagging approaches to directly monitor individual progenitor fate decisions at the clonal and popu

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Cool, Simon M., and Victor Nurcombe. "Heparan sulfate regulation of progenitor cell fate." Journal of Cellular Biochemistry 99, no. 4 (2006): 1040–51. http://dx.doi.org/10.1002/jcb.20936.

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O'Connor, Caitriona, Joana Campos, Brian Murphy, et al. "NFIX influences stem and progenitor lineage fate." Experimental Hematology 42, no. 8 (2014): S54. http://dx.doi.org/10.1016/j.exphem.2014.07.205.

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Alexiades, M. R., and C. L. Cepko. "Subsets of retinal progenitors display temporally regulated and distinct biases in the fates of their progeny." Development 124, no. 6 (1997): 1119–31. http://dx.doi.org/10.1242/dev.124.6.1119.

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Cell fate determination in the developing vertebrate retina is characterized by the sequential generation of seven classes of cells by multipotent progenitor cells. Despite this order of genesis, more than one cell type is generated at any time; for example, in the rat, several cell types are born during the prenatal period, while others are born postnatally. In order to examine whether there are classes of progenitor cells with distinct developmental properties contributing to this developmental progression, we examined antigen expression in progenitor cells during rat retinal development. Tw

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Redkar, Abhay, Michael Montgomery, and Judith Litvin. "Fate map of early avian cardiac progenitor cells." Development 128, no. 12 (2001): 2269–79. http://dx.doi.org/10.1242/dev.128.12.2269.

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Cardiogenic fate maps are used to address questions on commitment, differentiation, morphogenesis and organogenesis of the heart. Recently, the accuracy of classical cardiogenic fate maps has been questioned, raising concerns about the conclusions drawn in studies based on these maps. We present accurate fate maps of the heart-forming region (HFR) in avian embryos and show that the putative cardiogenic molecular markers Bmp2 and Nkx2.5 do not govern the boundaries of the HFR as suggested in the literature. Moreover, this paper presents the first fate map of the HFR at stage 4 and addresses a v

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Tanaka, Yuya, Hiroki Kato, Sayaka Sano, et al. "Transcription Factor Gata2 Regulates the Myeloid-Lymphoid Fate Decision in Multipotent Progenitors." Blood 144, Supplement 1 (2024): 4037. https://doi.org/10.1182/blood-2024-207236.

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Hematopoiesis is a continuous process of differentiation whereby hematopoietic stem cells (HSCs) and multipotent progenitor cells (MPPs) generate diverse cell types encompassing myeloid and lymphoid lineages. This dynamic differentiation is orchestrated by transcription factors that regulate gene regulatory networks (GRNs), promoting expected lineage-specific gene expression while concomitantly repressing alternative lineage genes. A transcription factor Gata2, a zinc finger DNA binding protein, has been identified as a master regulator in HSC emergence and maintenance. We previously revealed

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Reddy, G. V., and V. Rodrigues. "A glial cell arises from an additional division within the mechanosensory lineage during development of the microchaete on the Drosophila notum." Development 126, no. 20 (1999): 4617–22. http://dx.doi.org/10.1242/dev.126.20.4617.

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We have used different cell markers to trace the development of the sensory cells of the thoracic microchaete. Our results dictate a revision in the currently accepted model for cell lineage within the mechanosensory bristle. The sensory organ progenitor divides to form two secondary progenitors: PIIa and PIIb. PIIb divides first to give rise to a tertiary progenitor-PIII and a glial cell. This is followed by division of PIIa to form the shaft and socket cells as described before. PIII expresses high levels of Elav and low levels of Prospero and divides to produce neuron and sheath. Its siblin

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Lawrence, Diane M. P., Linda C. Durham, Lynnae Schwartz, Pankaj Seth, Dragan Maric, and Eugene O. Major. "Human Immunodeficiency Virus Type 1 Infection of Human Brain-Derived Progenitor Cells." Journal of Virology 78, no. 14 (2004): 7319–28. http://dx.doi.org/10.1128/jvi.78.14.7319-7328.2004.

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ABSTRACT Although cells of monocytic lineage are the primary source of human immunodeficiency virus type 1 (HIV-1) in the brain, other cell types in the central nervous system, including astrocytes, can harbor a latent or persistent HIV-1 infection. In the present study, we examined whether immature, multipotential human brain-derived progenitor cells (nestin positive) are also permissive for infection. When exposed to IIIB and NL4-3 strains of HIV-1, progenitor cells and progenitor-derived astrocytes became infected, with peak p24 levels of 100 to 500 pg/ml at 3 to 6 days postinfection. After

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Zhu, Jianjian, Kin Ming Kwan, and Susan Mackem. "Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT." Proceedings of the National Academy of Sciences 113, no. 14 (2016): 3820–25. http://dx.doi.org/10.1073/pnas.1601252113.

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The transcription factor Brachyury (T) gene is expressed throughout primary mesoderm (primitive streak and notochord) during early embryonic development and has been strongly implicated in the genesis of chordoma, a sarcoma of notochord cell origin. Additionally, T expression has been found in and proposed to play a role in promoting epithelial–mesenchymal transition (EMT) in various other types of human tumors. However, the role of T in normal mammalian notochord development and function is still not well-understood. We have generated an inducible knockdown model to efficiently and selectivel

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McGrath, Kathleen E., Jenna M. Cacciatori, Anne D. Koniski, and James Palis. "Complete Myeloid Potential Arises First in the Mammalian Yolk Sac." Blood 112, no. 11 (2008): 730. http://dx.doi.org/10.1182/blood.v112.11.730.730.

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Abstract In the mouse embryo, hematopoietic function is required by E10.5 (embryonic day 10.5) before adult-repopulating hematopoietic stem cells (HSC) exist. The earliest erythroid function is provided by a wave of primitive erythroid progenitors that arise at E7.5, in association with megakaryocyte and macrophage progenitors. Intriguingly, a second wave of hematopoietic potential arises between the first primitive hematopoietic wave and functional HSC formation. This second progenitor wave also forms in the yolk sac but is distinguished from the primitive wave by its slightly later onset (E8

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Eagleson, K. L., L. Lillien, A. V. Chan, and P. Levitt. "Mechanisms specifying area fate in cortex include cell-cycle-dependent decisions and the capacity of progenitors to express phenotype memory." Development 124, no. 8 (1997): 1623–30. http://dx.doi.org/10.1242/dev.124.8.1623.

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Progenitor cells in the early developing cerebral cortex produce neurons destined for discrete functional areas in response to specific inductive signals. Using lineage analysis, we show that cortical progenitor cells at different fetal ages retain the memory of an area-specific inductive signal received in vivo, even though they may pass through as many as two cell cycles in the absence of the signal in culture. When exposed to inductive signals in vitro, only those progenitors that progress through at least one complete cell cycle alter their areal phenotype. Our findings suggest that induct

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Buff, E., A. Carmena, S. Gisselbrecht, F. Jimenez, and A. M. Michelson. "Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors." Development 125, no. 11 (1998): 2075–86. http://dx.doi.org/10.1242/dev.125.11.2075.

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Muscle development initiates in the Drosophila embryo with the segregation of single progenitor cells, from which a complete set of myofibres arises. Each progenitor is assigned a unique fate, characterized by the expression of particular identity genes. We now demonstrate that the Drosophila epidermal growth factor receptor provides an inductive signal for the specification of a large subset of muscle progenitors. In the absence of the receptor or its ligand, SPITZ, specific progenitors fail to segregate. The resulting unspecified mesodermal cells undergo programmed cell death. In contrast, r

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Saran, Namita, Marcin Łyszkiewicz, Jens Pommerencke, et al. "Multiple extrathymic precursors contribute to T-cell development with different kinetics." Blood 115, no. 6 (2010): 1137–44. http://dx.doi.org/10.1182/blood-2009-07-230821.

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Abstract T-cell development in the thymus depends on continuous supply of T-cell progenitors from bone marrow (BM). Several extrathymic candidate progenitors have been described that range from multipotent cells to lymphoid cell committed progenitors and even largely T-lineage committed precursors. However, the nature of precursors seeding the thymus under physiologic conditions has remained largely elusive and it is not known whether there is only one physiologic T-cell precursor population or many. Here, we used a competitive in vivo assay based on depletion rather than enrichment of classes

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Passegue, Emmanuelle, Camilla Forsberg, Thomas Serwold, Scott Kogan, and Irving L. Weissman. "Investigation of Hematopoietic Stem Cell and Progenitor Populations: Implication for Cell Fate Determination and Lineage Commitment." Blood 106, no. 11 (2005): 801. http://dx.doi.org/10.1182/blood.v106.11.801.801.

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Abstract A thorough understanding of the lineage potential of each subset of hematopoietic stem cells (HSC) and progenitor populations is critical to establish an accurate map of cell fate determination during hematopoietic development. A controversy exists whether multipotentiality is conserved until a mutually exclusive segregation of myeloid and lymphoid potentials or whether early progenitor populations sequentially lose lineage potential as they differentiate from the long-term self-renewing HSC (LT-HSC), starting with loss of megakaryocyte/erythrocyte (MegE) potential. Hematopoietic cell

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Allen, Nicholas D. "Temporal and epigenetic regulation of neurodevelopmental plasticity." Philosophical Transactions of the Royal Society B: Biological Sciences 363, no. 1489 (2007): 23–38. http://dx.doi.org/10.1098/rstb.2006.2010.

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The anticipated therapeutic uses of neural stem cells depend on their ability to retain a certain level of developmental plasticity. In particular, cells must respond to developmental manipulations designed to specify precise neural fates. Studies in vivo and in vitro have shown that the developmental potential of neural progenitor cells changes and becomes progressively restricted with time. For in vitro cultured neural progenitors, it is those derived from embryonic stem cells that exhibit the greatest developmental potential. It is clear that both extrinsic and intrinsic mechanisms determin

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Ziętara, Natalia, Marcin Łyszkiewicz, Jacek Puchałka, et al. "Multicongenic fate mapping quantification of dynamics of thymus colonization." Journal of Experimental Medicine 212, no. 10 (2015): 1589–601. http://dx.doi.org/10.1084/jem.20142143.

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Postnatal T cell development depends on continuous colonization of the thymus by BM-derived T lineage progenitors. Both quantitative parameters and the mechanisms of thymus seeding remain poorly understood. Here, we determined the number of dedicated thymus-seeding progenitor niches (TSPNs) capable of supporting productive T cell development, turnover rates of niche occupancy, and feedback mechanisms. To this end, we established multicongenic fate mapping combined with mathematical modeling to quantitate individual events of thymus colonization. We applied this method to study thymus colonizat

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