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Journal articles on the topic 'Progestational hormones'

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Published: 4 June 2021

Last updated: 27 July 2024

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1

Elbers, J. M. H., H. Asscheman, J. C. Seidell, and L. J. G. Gooren. "Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals." American Journal of Physiology-Endocrinology and Metabolism 276, no. 2 (1999): E317—E325. http://dx.doi.org/10.1152/ajpendo.1999.276.2.e317.

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We investigated prospectively the effect of sex steroids on regional fat depots and thigh muscle mass in adult transsexuals. Ethinyl estradiol in combination with cyproterone acetate, a progestational antiandrogen, was given to 20 male-to-female (M-F) transsexuals, and parenteral testosterone esters were given to 17 female-to-male (F-M) transsexuals. Before and after 12 mo of cross-sex hormone administration, several anthropometric measurements (weight, skinfolds, body circumferences, and bioimpedance) were performed, and transverse magnetic resonance images were obtained at the level of the a

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2

Dikke, G. B. "Therapeutic tactics with violations of the menstrual cycle caused by ovulative dysfunction." Medical Council, no. 13 (September 25, 2018): 40–44. http://dx.doi.org/10.21518/2079-701x-2018-13-40-44.

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Purpose: presentation of modern data on the pathogenesis of menstrual cycle disorders (NMCs) associated with ovulatory dysfunction, and the effectiveness of their treatment with medication.Basic provisions. It is shown that NMC is the result of violations of the cyclic production of gonadotropic and sex hormones. Among the hormonal drugs for the treatment of NMCs, combined estrogen-progestational oral contraceptives (COCs), especially those with drospirenone (DRSP), are advantageous. The introduction of calcium levomefolate - biologically active form of folatein the composition of COCs contain

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3

Shehu, Bello B., and Nasiru J. Ismail. "Convexity Meningioma Presenting as Postpartum Eclampsia." Tropical Doctor 33, no. 1 (2003): 53–54. http://dx.doi.org/10.1177/004947550303300126.

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A 37-year-old woman, Para 5+0 presented with a 1 year history of recurrent convulsions and progressive weakness of the right side of the body. She had been treated for postpartum eclampsia in her last delivery but symptoms recurred 3 months later. Evaluation including computerized tomography scan of the brain suggested a parieto-temporal meningioma, which was completely excised at craniotomy. Histology confirmed this to be a meningioma. The patient was well at 8 months of follow up. The growth of meningiomas may increase during pregnancy due to presence of receptors for progestational hormones

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4

Casslén, Bertil G., Theresa M. Siler-Khodr, and Michael J. K. Harper. "Progesterone regulation of prolactin release from human endometrial stromal cells in culture: Potential bioassay for progestational activity." Acta Endocrinologica 122, no. 1 (1990): 137–44. http://dx.doi.org/10.1530/acta.0.1220137.

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Abstract Prolactin was produced by endometrial stromal cells, but not by epithelial cells, in primary culture. Production was stimulated by progesterone in a time and dose (1–1000 nmol/1) dependent way. Stimulation was started one day after plating. The release of prolactin started one day earlier in cultures from luteal phase than proliferative phase endometria. The responsiveness to progesterone declined with time in culture, sooner in luteal than in proliferative phase cultures, but could, at least partly, be maintained by including estradiol (10 nmol/l) in the medium. Lost response to prog

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5

Köhlerová, E., J. Kotanová, and J. Škarda. "Biological Responses of Antiprogestins in Mammary Gland, Uterus and Seminal Vesicles of Prepubertal Intact and Adult Gonadectomized Mice." Acta Veterinaria Brno 75, no. 3 (2006): 319–28. http://dx.doi.org/10.2754/avb200675030319.

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The present study tested and compared the antiproliferative and proliferative activities of three antiprogestins on four separate mouse model systems: prepubertal intact and adult ovariectomized (OVX) females, prepubertal intact and adult castrated males. In prepubertal intact males and females and adult castrated males, norethindrone acetate (NA; a synthetic steroid exhibiting progestational and estrogenic activities)- stimulated mammary growth was decreased by antiprogestins: more by RU 46556 (RU) than RU 38486 (MI) and onapristone (ON). In adult OVX females the inhibitory effect of RU and M

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6

Moodley, M., J. Moodley, R. Chetty, and C. S. Herrington. "The role of steroid contraceptive hormones in the pathogenesis of invasive cervical cancer: A review." International Journal of Gynecologic Cancer 13, no. 2 (2003): 103–10. http://dx.doi.org/10.1136/ijgc-00009577-200303000-00001.

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Invasive cervical cancer remains a leading cause of morbidity and mortality, especially among women in the developing world where screening is either deficient or absent. Of all agents linked to the causation of this disease, high-risk human papillomavirus (HPV) appears to be the strongest factor. However, not all women with HPV develop cervical cancer. Steroid contraception has been postulated to be one mechanism whereby HPV exerts its tumorigenic effect on cervical tissue. Steroids are thought to bind to specific DNA sequences within transcriptional regulatory regions on the HPV DNA to eithe

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7

Muruganandan, Shanmugam, Xiujun Fan, Sabita Dhal, and Nihar R. Nayak. "Development of A 3D Tissue Slice Culture Model for the Study of Human Endometrial Repair and Regeneration." Biomolecules 10, no. 1 (2020): 136. http://dx.doi.org/10.3390/biom10010136.

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The human endometrium undergoes sequential phases of shedding of the upper functionalis zone during menstruation, followed by regeneration of the functionalis zone from the remaining basalis zone cells, and secretory differentiation under the influence of the ovarian steroid hormones estradiol (E2) and progesterone (P4). This massive tissue regeneration after menstruation is believed to arise from endometrial stromal and epithelial stem cells residing in the basal layer of the endometrium. Although many endometrial pathologies are thought to be associated with defects in these stem cells, stud

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8

Pankhurst, N. W. "Final maturation and ovulation of oocytes of the goldeye, Hiodon alosoides (Rafinesque), in vitro." Canadian Journal of Zoology 63, no. 5 (1985): 1003–9. http://dx.doi.org/10.1139/z85-149.

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Oocytes from preovulatory goldeye were cultured in vitro and final maturation was observed in response to treatment with piscine gonadotropins (GtH) and progestational steroids. Final maturation consisted of nuclear migration and breakdown, and coalescence of yolk material to form a single large oil droplet. Both events were under hormonal control with median effective dose values of 1–5 μg∙mL−1 for piscine GtH and 0.1–0.6 μg∙mL−1 for pregnenolone, progesterone, 17αOH pregnenolone, 17αOH progesterone, and 17α,20β-dihydroxy-4-pregnen-3-one. Neither cortisol nor triiodothyronine potentiated the

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9

HASHIMOTO, Inoru, Tsuyoshi OKUDAIRA, Atushi KANAYAMA, Kenichiro MUTOH, and Mitsumori KAWAMINAMI. "Preprogramming of luteal progestational function by preovulatory luteinizing hormone surge in cycling rats." Japanese journal of animal reproduction 36, no. 1 (1990): 41–53. http://dx.doi.org/10.1262/jrd1977.36.41.

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10

Giatti, Silvia, Roberto Cosimo Melcangi, and Marzia Pesaresi. "The other side of progestins: effects in the brain." Journal of Molecular Endocrinology 57, no. 2 (2016): R109—R126. http://dx.doi.org/10.1530/jme-16-0061.

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Progestins are a broad class of progestational agents widely differing in their chemical structures and pharmacological properties. Despite emerging data suggest that progestins, besides their action as endometrial protection, can also have multiple nonreproductive functions, much remains to be discovered regarding the actions exerted by these molecules in the nervous system. Here, we report the role exerted by different progestins, currently used for contraception or in postmenopausal hormone replacement therapies, in regulating cognitive functions as well as social behavior and mood. We prov

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11

Renke, Guilherme, Consuelo Callizo, Raphaela Paes, et al. "Clinical Approaches to Nestorone Subdermal Implant Therapy in Women’s Health." Biomedicines 11, no. 9 (2023): 2586. http://dx.doi.org/10.3390/biomedicines11092586.

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Segesterone acetate (SA) or Nestorone, a fourth-generation progestogen, is a synthetic compound with high progestational activity and no androgenic, glucocorticoid, or anabolic effects. However, due to its oral inactivity, SA must be used by other routes, such as subcutaneous. Thus, considering its peculiar properties, the SA subdermal implant is successfully used in female contraception and postmenopausal hormone replacement therapy (HRT). In recent years, its potential uses in endometriosis, polycystic ovaries syndrome (PCOS), and a new therapeutic possibility for neuroprotection have made t

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12

Byrjalsen, Inger, Nina H. Bjarnason, and Claus Christiansen. "Progestational effects of combinations of gestodene on the postmenopausal endometrium during hormone replacement therapy." American Journal of Obstetrics and Gynecology 180, no. 3 (1999): 539–49. http://dx.doi.org/10.1016/s0002-9378(99)70251-6.

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13

García-Becerra, Rocío, David Ordaz-Rosado, Gabriela Noé, Bertha Chávez, Austin J. Cooney та Fernando Larrea. "Comparison of 7α-methyl-19-nortestosterone effectiveness alone or combined with progestins on androgen receptor mediated-transactivation". REPRODUCTION 143, № 2 (2012): 211–19. http://dx.doi.org/10.1530/rep-11-0171.

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7α-methyl-19-nortestosterone (MENT) is an androgen with potent gonadotropin inhibitory activity and prostate-sparing effects. These attributes give MENT advantages over testosterone as a male contraceptive, but, as in the case of testosterone, a partial dose-dependent suppression of spermatogenesis has been observed. Combination of testosterone or MENT with synthetic progestins improves the rate of azoospermia; however, it is unknown whether these combinations affect hormone androgenicity or exert synergistic effects via progestational or androgenic interaction. Herein, using transactivation a

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14

Bouchard, Thomas P. "Using Quantitative Hormonal Fertility Monitors to Evaluate the Luteal Phase: Proof of Concept Case Study." Medicina 59, no. 1 (2023): 140. http://dx.doi.org/10.3390/medicina59010140.

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Several new quantitative fertility monitors are now available for at-home use that measure estrogen, luteinizing hormone (LH), and progesterone (PDG) in urine. This case report compares the Mira and Inito quantitative fertility monitors with the well-established qualitative ClearBlue fertility monitor. Three clinical scenarios were evaluated: a normal cycle, a prolonged luteinization cycle, and an anovulatory cycle. The identification of the luteal phase (or lack thereof in the case of anovulation) and the transition through the three processes of luteinization, progestation, and luteolysis we

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15

DeMayo, Francesco J., and John P. Lydon. "90 YEARS OF PROGESTERONE: New insights into progesterone receptor signaling in the endometrium required for embryo implantation." Journal of Molecular Endocrinology 65, no. 1 (2020): T1—T14. http://dx.doi.org/10.1530/jme-19-0212.

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Progesterone’s ability to maintain pregnancy in eutherian mammals highlighted this steroid as the ‘hormone of pregnancy’. It was the unique ‘pro-gestational’ bioactivity of progesterone that enabled eventual purification of this ovarian steroid to crystalline form by Willard Myron Allen in the early 1930s. While a functional connection between normal progesterone responses (’progestational proliferation’) of the uterus with the maintenance of pregnancy was quickly appreciated, an understanding of progesterone’s involvement in the early stages of pregnancy establishment was comparatively less w

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16

MANN, DAVID R., DELWOOD C. COLLINS, MARJORIE M. SMITH, MATT J. KESSLER, and KENNETH G. GOULD. "Treatment of Endometriosis in Monkeys: Effectiveness of Continuous Infusion of a Gonadotropin-Releasing Hormone Agonist Compared to Treatment with a Progestational Steroid*." Journal of Clinical Endocrinology & Metabolism 63, no. 6 (1986): 1277–83. http://dx.doi.org/10.1210/jcem-63-6-1277.

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17

IRAHARA, MINORU, TASUKU HARADA, MIKIO MOMOEDA, and YUJI TAMAKI. "Hormonal and histological study on irregular genital bleeding in patients with endometriosis during treatment with dienogest, a novel progestational therapeutic agent." Reproductive Medicine and Biology 6, no. 4 (2007): 223–28. http://dx.doi.org/10.1111/j.1447-0578.2007.00189.x.

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18

Kaushic, Charu, Ali A. Ashkar, Lesley A. Reid, and Kenneth L. Rosenthal. "Progesterone Increases Susceptibility and Decreases Immune Responses to Genital Herpes Infection." Journal of Virology 77, no. 8 (2003): 4558–65. http://dx.doi.org/10.1128/jvi.77.8.4558-4565.2003.

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ABSTRACT Depo-provera, a long-acting progestational formulation, is widely used to facilitate infection of sexually transmitted diseases in animal models. We have previously reported that hormone treatments change susceptibility and immune responses to genital tract infections. In this study we compared the changes in susceptibility of mice to genital herpes simplex virus type 2 (HSV-2) after Depo-provera or a saline suspension of progesterone (P-sal). We found that following Depo-provera-treatment, mice had prolonged diestrus that lasted more than 4 weeks. This coincided with a 100-fold incre

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19

GELLER, JACK. "Overview of Enzyme Inhibitors and Anti‐Androgens in Prostatic Cancer." Journal of Andrology 12, no. 6 (1991): 364–71. http://dx.doi.org/10.1002/j.1939-4640.1991.tb00274.x.

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AbstractSurgical castration and estrogen therapy for prostate cancer were developed in 1941, and have been shown to improve both quality of life and survival. Little change in the therapeutics of prostate cancer has occurred over the subsequent three decades. In the 1970s, the progestational anti‐androgens, ketoconazole and flutamide, were introduced as androgen‐blocking agents, and have been shown to block at least partially both adrenal and testicular androgens. Gonadotropin‐releasing hormone (GnRH) agonists were shown in the 1980s to produce medical castration without the cardiac and cerebr

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20

Loprinzi, Charles L., Ralph Levitt, Debra Barton, et al. "Phase III Comparison of Depomedroxyprogesterone Acetate to Venlafaxine for Managing Hot Flashes: North Central Cancer Treatment Group Trial N99C7." Journal of Clinical Oncology 24, no. 9 (2006): 1409–14. http://dx.doi.org/10.1200/jco.2005.04.7324.

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Purpose Vasomotor hot flashes are a common problem in menopausal women. Given concerns regarding estrogen and/or combined hormonal therapy, other treatment options are desired. Prior trials have confirmed that progestational agents and newer antidepressants effectively reduce hot flashes. This current trial compared a single intramuscular dose of medroxyprogesterone acetate (MPA), depot preparation, versus daily oral venlafaxine as treatment for hot flashes. Methods Women with bothersome hot flashes were entered onto this trial, were randomly assigned to treatment, and then had a baseline week

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21

Branco, L. P., R. Dienstmann, and J. Bines. "Megestrol acetate after aromatase inhibitor failure in metastatic breast cancer." Journal of Clinical Oncology 24, no. 18_suppl (2006): 10572. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.10572.

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10572 Background: As aromatase inhibitors (AI) are now an essential component of the adjuvant hormonal treatment in breast cancer, it is important to define strategies after progression. Progestational agents have significant activity in endocrine-responsive breast cancer. This is the first report of megestrol acetate (MA) after AI failure. Methods: We have retrospectively reviewed the charts of all patients treated with MA for the last 2 years at the Instituto Nacional de Câncer, in Brazil. All the patients were postmenopausal and had metastatic breast cancer. The treatment sequence was as fo

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22

Singh, MM, SC Chauhan, RN Trivedi, SC Maitra, and VP Kamboj. "Correlation of pinopod development on uterine luminal epithelial surface with hormonal events and endometrial sensitivity in rat." European Journal of Endocrinology 135, no. 1 (1996): 107–17. http://dx.doi.org/10.1530/eje.0.1350107.

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Singh MM, Chauhan SC, Trivedi RN, Maitra SC, Kamboj VP. Correlation of pinopod development on uterine luminal epithelial surface with hormonal events and endometrial sensitivity in rat. Eur J Endocrinol 1996;135:107–17. ISSN 0804–4643 Intrinsic role of preovulatory and nidatory estrogen and progesterone and presence of viable blastocysts in utero in pinopod development on the uterine luminal epithelial surface and correlation between time of their development and onset of endometrial sensitivity were investigated. In adult rats, pinopods were observed on the entire epithelium even before secre

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23

Voorhoof, L., M. Rosseneu, H. Caster, and W. De Keersgieter. "Metabolic effects of a biphasic oral contraceptive preparation containing ethinyloestradiol and desogestrel on serum lipoproteins and apolipoproteins." Journal of Endocrinology 111, no. 1 (1986): 191–96. http://dx.doi.org/10.1677/joe.0.1110191.

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ABSTRACT The effect of the administration of a biphasic oral contraceptive containing ethinyloestradiol and desogestrel on the distribution and composition of serum lipoproteins was studied in a group of 17 healthy female volunteers. The women were treated for a period of 6 months and compared with a control group of ten untreated volunteers. The serum lipoproteins were fractionated by density gradient ultracentrifugation into very low density lipoproteins (VLDL), low density lipoproteins (LDL), and into the high density lipoprotein (HDL) subfractions 2 and 3 (HDL2, HDL3). Lipids and apolipopr

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24

Attardi, Barbara J., Sailaja Koduri, and Sheri A. Hild. "Relative progestational and androgenic activity of four progestins used for male hormonal contraception assessed in vitro in relation to their ability to suppress LH secretion in the castrate male rat." Molecular and Cellular Endocrinology 328, no. 1-2 (2010): 16–21. http://dx.doi.org/10.1016/j.mce.2010.06.010.

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25

Lemus, AE, V. Zaga, R. Santillan, et al. "The oestrogenic effects of gestodene, a potent contraceptive progestin, are mediated by its A-ring reduced metabolites." Journal of Endocrinology 165, no. 3 (2000): 693–702. http://dx.doi.org/10.1677/joe.0.1650693.

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Gestodene (17 alpha-ethynyl-13 beta-ethyl-17 beta-hydroxy-4, 15-gonadien-3-one) is the most potent synthetic progestin currently available and it is widely used as a fertility regulating agent in a number of contraceptive formulations because of its high effectiveness, safety and acceptability. The observation that contraceptive synthetic progestins exert hormone-like effects other than their progestational activities, prompted us to investigate whether gestodene (GSD) administration may induce oestrogenic effects, even though the GSD molecule does not interact with intracellular oestrogen rec

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26

Beltz, Adriene M., Amy M. Loviska, Dominic P. Kelly, and Matthew G. Nielson. "The Link Between Masculinity and Spatial Skills Is Moderated by the Estrogenic and Progestational Activity of Oral Contraceptives." Frontiers in Behavioral Neuroscience 15 (January 27, 2022). http://dx.doi.org/10.3389/fnbeh.2021.777911.

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Conversations about gender and spatial skills frequently dissolve into a hackneyed debate over nature and nurture. This is particularly true for conversations concerning three-dimensional (3D) mental rotations skill, which shows the largest gender difference of all aspects of cognition, with men—on average—outperforming women. To advance this empirical area of inquiry, biopsychosocial influences on spatial skills should be considered, and a unique opportunity do to that is provided by combined oral contraceptives (OCs). OCs with relatively low estradiol doses and with highly androgenic progest

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27

Ziecik, Adam J., Jan Klos, Katarzyna Gromadzka-Hliwa, et al. "Endocrine and molecular milieus of ovarian follicles are diversely affected by human chorionic gonadotropin and gonadotropin-releasing hormone in prepubertal and mature gilts." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-91434-6.

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AbstractDifferent strategies are used to meet optimal reproductive performance or manage reproductive health. Although exogenous human chorionic gonadotropin (hCG) and gonadotropin-releasing hormone (GnRH) agonists (A) are commonly used to trigger ovulation in estrous cycle synchronization, little is known about their effect on the ovarian follicle. Here, we explored whether hCG- and GnRH-A-induced native luteinizing hormone (LH) can affect the endocrine and molecular milieus of ovarian preovulatory follicles in pigs at different stages of sexual development. We collected ovaries 30 h after hC

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28

Santen, R. J., and H. A. Harvey. "Use of aromatase inhibitors in breast carcinoma." Endocrine-related cancer, March 1999, 75–92. http://dx.doi.org/10.1677/erc.0.0060075.

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Aromatase, a cytochrome P-450 enzyme that catalyzes the conversion of androgens to estrogens, is the major mechanism of estrogen synthesis in the post-menopausal woman. We review some of the recent scientific advances which shed light on the biologic significance, physiology, expression and regulation of aromatase in breast tissue. Inhibition of aromatase, the terminal step in estrogen biosynthesis, provides a way of treating hormone-dependent breast cancer in older patients. Aminoglutethimide was the first widely used aromatase inhibitor but had several clinical drawbacks. Newer agents are co

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29

Yuen, Fiona, Arthi Thirumalai, Ronald S. Swerdloff, et al. "SAT-040 Changes in Metabolic Parameters After Administration of Novel Oral Androgens with Progestational Activity for 28 Days." Journal of the Endocrine Society 4, Supplement_1 (2020). http://dx.doi.org/10.1210/jendso/bvaa046.1939.

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Abstract Background: While the metabolic effects of testosterone have been well studied, the effects of co-administration of an androgen and progestin are less established. Two novel compounds being investigated for male hormonal contraception, dimethandrolone undecanoate (DMAU) and 11β-methyl-19-nortestosterone dodecylcarbonate (11β-MNTDC), have both androgenic and progestational activity. Aim: Characterize the effects of DMAU and 11β-MNTDC on metabolic parameters including weight, lipid parameters, insulin resistance, and adiponectin. Methods: Two randomized, double-blind, placebo-controlled

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30

Khan, Mohammad Mojeeb Gulzar, Mohammad Faizan Saadique Deshmukh, Sandip Dinkar Firke, Abdul Talib Abdul Wahab, Mohan Ganpatrao Kalaskar, and Atul Arun Shirkhedkar. "New stability indicating RP-HPLC-PDA method for determination of mifepristone in bulk and tablet formulation." Future Journal of Pharmaceutical Sciences 7, no. 1 (2021). http://dx.doi.org/10.1186/s43094-021-00370-9.

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Abstract Background Mifepristone is progestational and glucocorticoid hormone antagonist. The objective of this study is to develop simple and economical stability indicating RP-HPLC method for the determination of mifepristone in bulk and tablet formulation. Result The chromatographic separation was achieved on Qualisil BDS C8 column with mobile phase containing of mixture of Buffer (Potassium dihydrogen ortho phosphate, pH to 3.0 with ortho phosphoric acid) and Organic Solvent (Acetonitrile) 60:40 v/v pumped at flow rate 0.6 mL min−1. The detection of elute was performed using PDA detector a

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Zhao, Hai, Jian Zhang, Ning Qian, Shuguang Wu, Yanjun Wu та Gang Yao. "Oxidative stress caused by a dysregulated Wnt/β-catenin signalling pathway is involved in abnormal placenta formation in pregnant mice with chronic fatigue syndrome". Zygote, 15 жовтня 2020, 1–8. http://dx.doi.org/10.1017/s096719942000057x.

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Summary Chronic fatigue syndrome (CFS) is characterized by extreme fatigue and disabling symptoms. Women with CFS often have a high risk of gynaecological problems such as irregular menstruation, endometriosis and pelvic pain and sexual dysfunction. Our previous results have shown that, in pregnant mice, CFS significantly decreased the progestational hormone level in serum, as well as learning and memory, and the function of the hypothalamus–pituitary–gonadal axis. In addition, the F1 generation also suffered from congenital hypothyroidism. At present, there has been no report about placenta f

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Wang, Ping, Zhilan Meng, Yakun Li, and Zuojun Xu. "Endometriosis-Related Pleural Effusion: A Case Report and a PRISMA-Compliant Systematic Review." Frontiers in Medicine 8 (March 30, 2021). http://dx.doi.org/10.3389/fmed.2021.631048.

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Background: Endometriosis-related pleural effusion (PE) is a relatively rare but treatable cause of bloody PE. The clinical characteristics and outcome of patients with endometriosis-related PE remain unknown.Objectives: We present a case of endometriosis-related PE diagnosed on pleural fluid cytology. A systematic review of all endometriosis-related PE cases in literature was conducted to elucidate the clinical characteristics, explore the diagnostic yield of pathological examinations, and to summarize the outcomes of therapeutic approaches in this disease.Methods: A case of endometriosis-rel

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