Journal articles: 'Prognosis ameloblastomas'

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Garcia, Natália Galvão, Denise Tostes Oliveira, and Moacyr Tadeu Vicente Rodrigues. "Unicystic Ameloblastoma with Mural Proliferation Managed by Conservative Treatment." Case Reports in Pathology 2016 (2016): 1–4. http://dx.doi.org/10.1155/2016/3089540.

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Unicystic ameloblastoma is a distinguishable entity of ameloblastomas, characterized by slow growth and being relatively locally aggressive. Three histological types are recognized according to the degree of ameloblastomatous epithelial extension, namely, luminal, intraluminal, and mural types. This classification has a direct bearing on their biological behavior, treatment, and prognosis. However, there is difficulty in determining the most appropriate form of treatment for unicystic ameloblastoma. We present a case of unicystic ameloblastoma that occurred in the right posterior mandible of 19-year-old girl, which was enucleated and did not recur after 12-month follow-up.

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Hasan, Shaza I. A., Sherief Y. M. El Nagdy, and Mona M. A. Ibrahim. "Prognostic significance of SOX2 and GPC3 in Ameloblastoma and its malignant counterpart (Ameloblastic Carcinoma)." Journal of Solid Tumors 11, no. 1 (2021): 1. http://dx.doi.org/10.5430/jst.v11n1p1.

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Background: Ameloblastoma is a common benign aggressive odontogenic tumor with a tendency for high recurrence rate. Ameloblastic Carcinoma is the malignant counterpart of Ameloblastoma. However, they are usually difficult to be distinguished from one another. Therefore, using Immunohistochemical markers might be beneficial for diagnosing them accurately.Objective: Evaluation of SOX2 and GPC3 expressions as well as evaluating their roles in the tumorigenesis and the biological behavior of Ameloblastoma and Ameloblastic Carcinoma.Methods: Tissue samples are composed of 34 archived histopathologically confirmed cases of (19 Conventional Ameloblastomas, and 15 Ameloblatic Carcinomas). Sections were subjected to Immunohistochemical staining according to a standard protocol by applying antibodies to SOX2, and GPC3.Results: SOX2 and GPC3 expressions in recurrent Ameloblastoma were significantly higher than non- recurrent cases. Ameloblastic Carcinoma showed the highest immune-reactivity to SOX2 and GPC3 compared to the Conventional Ameloblastoma. Desmoplastic Ameloblastoma showed the highest scores of SOX2 and GPC3 compared to the other subtypes.Conclusions: SOX2 and GPC3 can be used as a panel for diagnosing the aggressive and the malignant odontogenic tumors accurately. Desmoplastic Ameloblastoma behaves more aggressively than other Conventional Ameloblastoma subtypes.

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Brown, Noah A., and Bryan L. Betz. "Ameloblastoma: A Review of Recent Molecular Pathogenetic Discoveries." Biomarkers in Cancer 7s2 (January 2015): BIC.S29329. http://dx.doi.org/10.4137/bic.s29329.

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Ameloblastoma is an odontogenic neoplasm whose molecular pathogenesis has only recently been elucidated. The discovery of recurrent activating mutations in FGFR2, BRAF, and RAS in a large majority of ameloblastomas has implicated dysregulation of MAPK pathway signaling as a critical step in the pathogenesis of this tumor. Some degree of controversy exists regarding the role of mutations affecting the sonic hedgehog (SHH) pathway, specifically Smoothened (SMO), which have been postulated to serve as either an alternative pathogenetic mechanism or secondary mutations. Here, we review recent advances in our understanding of the molecular pathogenesis of ameloblastoma as well as the diagnostic, prognostic, and therapeutic implications of these discoveries.

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S., Mithra, Archana Santhanam, Herald J. Sherlin, Gifrina Jayaraj, and Don K.R. "Diagnostic Utility of Ki-67 for Histopathological Typing of Conventional Ameloblastoma, Proliferative Ameloblastoma and Ameloblastic Carcinoma – A Retrospective Study." Journal of Evolution of Medical and Dental Sciences 10, no. 32 (2021): 2592–96. http://dx.doi.org/10.14260/jemds/2021/531.

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BACKGROUND Ameloblastoma is a rare, benign odontogenic neoplasm which is locally aggressive and mostly present with a painless swelling. The enigma about the diagnosis of proliferative ameloblastoma and ameloblastic carcinoma is still a debate because the diagnostic criteria is not standardized or quantified which has a direct correlation on its biological behaviour and prognosis. Despite numerous studies, correlation between the histological patterns of ameloblastoma and tumour behaviour has not been consistently established. The present study was done to compare the expression levels of Ki-67 between conventional ameloblastoma, proliferative ameloblastoma and ameloblastic carcinoma and to assess the usefulness of these markers for diagnostic differentiation. METHODS A retrospective study of total of 18 cases of ameloblastoma were retrieved from the archives of Department of Oral and Maxillofacial Pathology, Saveetha Dental College from 2012 till 2019, which included conventional ameloblastoma, proliferative ameloblastoma and ameloblastic carcinoma. Immunohistochemical (IHC) analysis was done using the marker Ki-67 and labelling index were determined for the same. RESULTS The results of the current study showed that the cellular proliferative activity assessed using Ki-67 in follicular ameloblastoma was (55 %), 4 cases of plexiform ameloblastoma (22 %), 17 % of proliferative ameloblastoma and 6 % of ameloblastic carcinoma showed negative expression. CONCLUSIONS Immunophenotyping using the marker Ki-67 may be a useful tool for histological typing of ameloblastoma. KEY WORDS Ameloblastoma, Ki-67, IHC, Immunophenotyping

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Barboza, Carlos Augusto Galvão, Leão Pereira Pinto, Roseana de Almeida Freitas, Antônio de Lisboa Lopes Costa, and Lélia Batista de Souza. "Proliferating cell nuclear antigen (PCNA) and p53 protein expression in ameloblastoma and adenomatoid adontogenic tumor." Brazilian Dental Journal 16, no. 1 (2005): 56–61. http://dx.doi.org/10.1590/s0103-64402005000100010.

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In this study, proliferating cell nuclear antigen (PCNA) and p53 protein expressions were analyzed in 16 cases of ameloblastoma and 8 cases of adenomatoid odontogenic tumor (AOT). The cases of ameloblastoma consisted of solid type tumors and histologic arrangements of different subtypes were observed. In some specimens, more than one histologic subtype was identified in the same lesion, and each tumor was categorized according to the predominant cell pattern. The odontogenic tumors were grouped as follows: follicular ameloblastoma (n=7), plexiform ameloblastoma (n=4), acanthomatous + follicular ameloblastoma (n=3), basal cell ameloblastoma (n=2), adenomatoid odontogenic tumor (n=8). PCNA immunohistochemical expression revealed stronger quantitative labeling index for the follicular ameloblastoma, while for p53 protein the strongest quantitative labeling index was detected in the plexiform type. Nevertheless, statistical analysis using ANOVA and Tukey's test did not detect significant differences (p>0.05) among the histologic subtypes of ameloblastoma. The findings of this study suggest that the different histologic patterns of ameloblastoma did not show a direct correlation with their clinical behavior and consequently with the prognosis of the cases. The results also indicated that the ameloblastoma has greater proliferative potential than the AOT, which can contribute to explain its more aggressive and invasive characteristics.

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Yiannis, Callisthenis, Massimo Mascolo, Michele Davide Mignogna, et al. "Expression Profile of Stemness Markers CD138, Nestin and Alpha-SMA in Ameloblastic Tumours." International Journal of Environmental Research and Public Health 18, no. 8 (2021): 3899. http://dx.doi.org/10.3390/ijerph18083899.

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Ameloblastic carcinoma is a rare malignant odontogenic neoplasm with a poor prognosis. It can arise de novo or from a pre-existing ameloblastoma. Research into stemness marker expression in ameloblastic tumours is lacking. This study aimed to explore the immunohistochemical expression of stemness markers nestin, CD138, and alpha-smooth muscle actin (alpha-SMA) for the characterisation of ameloblastic tumours. Six cases of ameloblastoma and four cases of ameloblastic carcinoma were assessed, including one case of ameloblastic carcinoma arising from desmoplastic ameloblastoma. In all tumour samples, CD138 was positive, whilst alpha-SMA was negative. Nestin was negative in all but one tumour sample. Conversely, the presence or absence of these markers varied in stroma samples. Nestin was observed in one ameloblastic carcinoma stroma sample, whilst CD138 was positive in one ameloblastoma case, one desmoplastic ameloblastoma case, and in two ameloblastic carcinoma stroma samples. Finally, alpha-SMA was found positive only in the desmoplastic ameloblastoma stroma sample. Our results suggest nestin expression to be an indicator for ameloblastic carcinoma, and CD138 and alpha-SMA to be promising biomarkers for the malignant transformation of ameloblastoma. Our data showed that nestin, CD138, and alpha-SMA are novel biomarkers for a better understanding of the origins and behaviour of ameloblastic tumours.

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Gupta, Ashish, P. Balaji, Vinitra Vasan, and S. Latha. "Maxillary Ameloblastoma: A Rare Case Report." Journal of Health Sciences & Research 5, no. 2 (2014): 21–24. http://dx.doi.org/10.5005/jp-journals-10042-1005.

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ABSTRACT Ameloblastoma is a benign but locally aggressive odontogenic tumor. The knowledge about this tumor is gaining greater importance because of its emerging variants. It is very essential to know the clinical, radiological and histopathological features of all the subtypes of ameloblastoma along with their behavioral and prognostic characteristics. Worldwide, maxillary ameloblastoma is rare, but its late detection renders adequate treatment difficult. Majority occur in the mandible with about 5 to 20% occurring in the maxillary bone. Here, we report a case of follicular ameloblastoma of the anterior maxilla in a 60-year-old male. How to cite this article Vasan V, Balaji P, Latha S, Gupta A. Maxillary Ameloblastoma: A Rare Case Report. J Health Sci Res 2014;5(2):21-24.

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Tsimbalist, N. S., V. F. Rybalskaya, V. A. Semkin, A. I. Nerobeev, and I. I. Babichenko. "ON THE ISSUE OF THE PECULIARITIES OF SURGICAL TREATMENT OF VARIOUS HISTOLOGICAL VARIANTS OF AMELOBLASTOMA." Medical Council, no. 14 (November 14, 2017): 128–31. http://dx.doi.org/10.21518/2079-701x-2017-14-128-131.

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The typical treatment of ameloblastoma is by surgery. The result of the procedure nevertheless does not always lead to complete healing of the sickness but to a recurrence during the post-operative period. It has been reported by a number of authors that the recurrence of the condition is influenced by a number of factors such as the kind of surgical intervention, the histological variant of the ameloblastoma and the incomplete removal of the tumor. The purpose of this research is to study the incidence of recurrence of ameloblastoma after surgery, taking into consideration type of surgery and size of the tumor. A study of 76 cases of ameloblastoma with different histological structures was undertaken in the laboratory of pathological anatomy of Central Research Institute of Dental and Maxillofacial Surgery. Data such as the recurrence of the disease and tumors size was collected, registered and analysed. The size of the tumors was expressed in conventional units. The analysis showed that basal cell and plexiform variants of ameloblastoma are often relate to cases with aggressive clinical courses. The tendency to the recurrence of the disease was also observed in the follicular and acanthomatous variants. According to the results of this study, cases of peripheral variants of ameloblastoma have the best prognosis.

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Gloria, Jonel Donn Leo S. "Extragnathic Sinonasal Ameloblastoma: A Rare Benign Intranasal Tumor with Malignant Features." Philippine Journal of Otolaryngology-Head and Neck Surgery 28, no. 1 (2013): 19–23. http://dx.doi.org/10.32412/pjohns.v28i1.497.

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Objective: To report a case of extragnathic sinonasal ameloblastoma and discuss its clinical features, approach to diagnosis, pathology, and management.  Methods: Study Design: Case report Setting: Tertiary government university hospital Subject: One  Results: A 40-year-old female consulted for a rapidly enlarging right intranasal mass of 4 months duration associated with recurrent profuse epistaxis and nasal obstruction. Previous specimens of the mass were histopathologically interpreted as ameloblastoma versus craniopharyngioma. Examination revealed a pink, fleshy, smooth right intranasal mass with associated nasomaxillary bulge and supero-lateral displacement of the right eye. Computed tomography (CT) scan and magnetic resonance imaging (MRI) of the nasal cavity and paranasal sinuses demonstrated a soft-tissue density occupying the entire nasal cavity with erosion but no invasion of the maxillary sinus and no intracranial extension despite erosion of the skull base. The mass was completely excised via lateral rhinotomy and the final histopathologic diagnosis was ameloblastoma.  Conclusion: Extragnathic sinonasal ameloblastoma is a benign but locally aggressive variant of ameloblastoma involving the nasal cavity and/or paranasal sinuses often mimicking malignant tumors. Diagnosis is primarily based on histopathology but radiologic and intraoperative findings help distinguish it from differentials. Complete surgical excision remains the treatment of choice, and coupled with good follow up, may improve the prognosis of patients.  Keywords: sinonasal ameloblastoma, extragnathic, craniopharyngioma

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Nakajima, T. "Treatment and prognosis of ameloblastoma—indication for marsupialization." Journal of Oral and Maxillofacial Surgery 47, no. 11 (1989): 1237. http://dx.doi.org/10.1016/0278-2391(89)90034-7.

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Kim, Ms Jueyoung, Ms Jinsun Kim, Dr Shadavlonjid Bazarsad, Prof Sung-won Cho, and Prof Jin Kim. "OPG AND BCL-2 PROMOTE AMELOBLASTOMA CELL TUMORIGENESIS AND PREDICT PROGNOSIS FOR AMELOBLASTOMA PATIENTS." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 128, no. 1 (2019): e58. http://dx.doi.org/10.1016/j.oooo.2019.02.134.

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SILVA, Joyce Natiele da, Cassiano Nogueira dos SANTOS, André Caroli ROCHA, Marina Lara de CARLI, João Adolfo Costa HANEMANN, and Alessandro Antônio Costa PEREIRA. "Extensive ameloblastoma in young patient: 5-year follow-up with no recurrence using conservative treatment." RGO - Revista Gaúcha de Odontologia 66, no. 2 (2018): 181–86. http://dx.doi.org/10.1590/1981-8637201800020000133357.

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ABSTRACT Ameloblastoma is a benign, odontogenic tumor that, due to its low rate of incidence, slow growth and local invasiveness, can be treated with a variety of surgical approaches, ranging from conservative to radical procedures. The conventional variant of ameloblastoma, though, is more aggressive and common, presenting a higher rate of recurrence than the unicystic and extraosseous/peripheral types; usually, the treatment of choice for this variant employs more invasive procedures. This report is of a 13-year-old male patient who presented with a swelling on the posterior mandibular region, on the left side of his face. Intraoral examination revealed lingual displacement of teeth 36 and 37. The clinical, radiographic and histopathological analyses confirmed the diagnosis of ameloblastoma (plexiform histological type). The patient was treated with curettage and peripheral osteotomy and a 5-year follow-up examination showed the area to have healed completely, with no evidence of recurrence. Consequently, although the clinical management of ameloblastoma is often based on invasive surgical approaches, large tumors treated with conservative surgery are less aesthetically and functionally impaired, and may demonstrate good prognosis with no recurrence in the 5-year follow-up period, as in the case reported here.

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Chaudhary, Zainab, Sriram Krishnan, Pankaj Sharma, Rakesh Sharma, and Priya Kumar. "A Review of Literature on Ameloblastoma in Children and Adolescents and a Rare Case Report of Ameloblastoma in a 3-Year-Old Child." Craniomaxillofacial Trauma & Reconstruction 5, no. 3 (2012): 161–68. http://dx.doi.org/10.1055/s-0032-1313358.

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A rare case report of a plexiform unicystic ameloblastoma in a 3-year-old girl stimulated us to conduct a review of literature to understand the correlation of this tumor with various factors such as that of age, sex, histopathological correlation, and its incidence rates pertaining to children and adolescent population. This is a case report of ameloblastoma in a 3-year-old patient, along with a literature review of ameloblastoma in relation to age. A computerized literature search using Medline was conducted for published articles on treatment of ameloblastoma. MeSH phrases used in search were ameloblastoma AND age; ameloblastoma AND children. The search was restricted to published articles from 1970 to 2010, as the histological features were not clearly defined until 1st edition of WHO histological classification of odontogenic tumors of 1971, search parameter was also set to select literatures under English language only. An additional systematic hand search was also conducted simultaneously to identify other published articles, considering similar parameters as used for Medline search. Most of search result yielded literatures in which primary importance were given to treatment patterns and prognosis of intervention, there were not much specific article or meta analysis which reviewed on the affected age range of ameloblastoma exclusively. We reviewed the identified literatures with patients’ age, case numbers, incidence, sex, location, and histopathology. The statistical data collected were exported to SPSS 16.0 for windows software which performed a descriptive analysis giving an average mean age of 14.1 years (range from 4 to 20); with maximum mean age being 16.0 and minimum mean age being 10.8 with standard deviation of 1.60. Majority of lesions 91.86% (327 of 356) were found between the age group of 11 and 20 years, only 8.14% (29 of 356) were below the age of 10 years. This rare case report highlights occurrence of plexiform unicystic ameloblastoma in maxilla of a 3-year-old girl, which is very much incongruent with the various review of literature on ameloblastoma in children and adolescents. We have emphasized the significance of patient's age and histopathological pattern of the tumor as it has its influence on the treatment plan. However, there is much of research needed with focus in respect to age, histological pattern, and treatment outcomes.

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Agarwal, Sunil, Jonathan Mark, Changchun Xie, Enas Ghulam, and Yash Patil. "Survival and Prognosis for Malignant Tumors of Odontogenic Origin." Otolaryngology–Head and Neck Surgery 155, no. 1 (2016): 113–16. http://dx.doi.org/10.1177/0194599816639540.

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Objective Determine survival and factors affecting survival for patients with malignant tumors of odontogenic origin. Study Design Retrospective analysis of the National Cancer Institute’s SEER database (Surveillance, Epidemiology, and End Results). Setting Tertiary medical center. Subjects and Methods All cases of malignant tumors of odontogenic origin were extracted from the SEER database for the period of 1973 to 2011. Demographic, tumor-specific, and survival data were tabulated and Kaplan-Meier survival analysis conducted according to histopathologic results. Cox regression analysis stratified for histopathology was conducted to determine factors that influenced survival. Results A total of 308 cases of malignant tumors with odontogenic origin were analyzed. Malignant ameloblastoma accounted for 59.7% of cases, followed by malignant odontogenic tumor (35.4%; including odontogenic carcinoma, odontogenic sarcoma, primary intraosseous carcinoma, and ameloblastic carcinoma) and ameloblastic fibrosarcoma (2.9%). The overall mean and median were 229 and 227 months, respectively, while the 5-year survival rate was 81% for the entire cohort. Malignant ameloblastoma exhibited the best mean survival (237 months), whereas malignant odontogenic tumor (139 months) and ameloblastic fibrosarcoma (42 months) had lower mean survival rates. Younger age, surgery with adjuvant radiation, and smaller tumor size were found to improve survival. Conclusions Significantly different survival can be expected depending on individual tumor histopathology, tumor size, age at diagnosis, and treatment modality.

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Heba Ahmed Elhendawy, Heba Allah Ibrahim Taher, and Nadia Mostafa Lotfy. "Utilization of cell proliferation markers to diagnose cystic jaw pathologies." GSC Biological and Pharmaceutical Sciences 16, no. 3 (2021): 129–44. http://dx.doi.org/10.30574/gscbps.2021.16.3.0274.

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Markers of cell proliferation are widely used as diagnostic and prognostic tools. Coincident estimation of these markers increases the precise evaluation of the proliferative status of different tissues and can also be helpful in determining progression, aggressiveness and prognosis of the lesions. The current study investigated the expression of PCNA and MCM3 cell proliferation markers in 40 formalin fixed paraffin embedded tissue blocks of odontogenic keratocyst (OKC) and unicystic ameloblastoma (UA) cases using immunohistochemistry method. Markers` expression based on the intensity, percentage of positively stained cells and localization of reaction through the cyst lining epithelium was separately analyzed for each marker using Chi square test, the results of which were significant for the two markers (P < 0.05). Both markers revealed statistically significant differences between OKC and UA cases regarding markers expression intensity, positivity score and localization of reaction through the epithelium. Mural UA histologic variant was significantly different than luminal and intraluminal variants. The correlation coefficient between the two markers was found to be 0.86.

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Tomo, Saygo, Karina Gonzales Camara Fernandes, Mônica Kina, Luciana Estevam Simonato, Damaris Sprita da Silva, and Mariângela Borghi Ingraci de Lúcia. "Multicystic Ameloblastoma in Anterior Region of the Mandible treated by Partial Mandibulectomy." World Journal of Dentistry 7, no. 1 (2016): 36–40. http://dx.doi.org/10.5005/jp-journals-10015-1360.

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ABSTRACT Among all odontogenic tumors, multicystic ameloblastoma stands out as the most common one, originating from odontogenic epithelium, and despite these tumors are consi dered benign in nature, it shows a wide aggressive beha vior, growing through the trabeculae of spongy bone. Diagnosing multicystic amelo blastoma is frequently challenging, nevertheless, modern imaginologic advents have demonstrating high accuracy. Due to its locally invasive behavior, management of multicystic amelo blastoma has been theme for controversies in literature, nevertheless, most of researches seem to agree that aggressive surgical resection is the most effective approach for this tumor. This paper reports an uncommon case of multicystic ameloblastoma occurring in the anterior mandible region of a female patient. Clinical main manifestation consisted on an extensive swelling in chin region, associated to a bone expansion in anterior lower alveolar bone. The patient reported the lesion has growing slowly, and have not manifested any episode of pain or sensitivity loss. Panoramic radiography analysis revealed an extensive lesion with honeycomb aspect in mental region of the mandible, while the computed tomography analysis showed the vestibular expansion of the tumor with several osseous septa into the lesion. Chosen treatment for the tumor was the partial mandibulectomy incorporation a riskfree bone border, aiming to avoid recurrence, once the literature points high rates of recurrence in ameloblastic tumors conservatively treated. After tumor removal with a 1.5 cm safe bone, histologic analysis revealed no tumor tissue presence on health bone margin, establishing a good prognosis with no recurrence. Moreover, diagnosis performed based on clinicalradiographical evaluation was satisfactory, leading us to the right diagnosis. This case elucidates that clinical and imaginologic evaluation of ameloblastoma tumors is reliable for clinicians to define the right diagnosis for these lesions. Furthermore, it shows multicystic ameloblastoma might be treated by partial mandibulectomy with a magin of healthy bone with low recurrence chances and satisfactory quality of life. How to cite this article Tomo S, da Silva DS, de Lúcia MBI, Kina M, Fernandes KGC, Simonato LE. Multicystic Ameloblastoma in Anterior Region of the Mandible Treated by Partial Mandibulectomy. World J Dent 2016;7(1):3640.

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Heikinheimo, K., J. M. Huhtala, A. Thiel, et al. "The Mutational Profile of Unicystic Ameloblastoma." Journal of Dental Research 98, no. 1 (2018): 54–60. http://dx.doi.org/10.1177/0022034518798810.

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BRAF V600E is the most common mutation in conventional ameloblastoma (AM) of the mandible. In contrast, maxillary AMs appear to harbor more frequently RAS, FGFR2, or SMO mutations. Unicystic ameloblastoma (UAM) is considered a less aggressive variant of ameloblastoma, amenable to more conservative treatment, and classified as a distinct entity. The aim of this study was to characterize the mutation profile of UAM ( n = 39) and to compare it to conventional AM ( n = 39). The associations between mutation status and recurrence probability were also analyzed. In the mandible, 94% of UAMs (29/31, including 8/8 luminal, 6/8 intraluminal, and 15/15 mural subtypes) and 74% of AMs (28/38) revealed BRAF V600E mutations. Among the BRAF wild-type cases, 1 UAM showed a missense SMO mutation (p.L412F), whereas 2 NRAS (p.Q61R), 2 HRAS (p.Q61R), and 2 FGFR2 (p.C383R) activating mutations were identified in AM. Of the 3 maxillary UAMs, only 1 revealed a BRAF V600E mutation. Taken together, our findings demonstrate high frequency of activating BRAF V600E mutations in both UAM and AM of the mandible. In maxillary UAMs, the BRAF V600E mutation prevalence appears to be lower as was shown for AM previously. It could therefore be argued that UAM and AM are part of the spectrum of the same disease. AMs without BRAF V600E mutations were associated with an increased rate of local recurrence ( P = 0.0003), which might indicate that routine mutation testing also has an impact on prognosis.

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Widjanarko, Bambang, and Muhammad Masykur Rahmat. "Penatalaksanaan Ameloblastik Karsinoma pada Mandibula dengan Reseksi Segmental dan Pemasangan Mandible Reconstructive Plate." Majalah Kedokteran Gigi Indonesia 17, no. 1 (2016): 25. http://dx.doi.org/10.22146/majkedgiind.15981.

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Ameloblastik Karsinoma merupakan tumor odontogenik yang jarang ditemukan, dan bersifat agresif. Pada awalnya tumor ini menunjukkan gambaran histologis seperti ameloblastoma, tapi kemudian kehilangan diferensiasi dan menjadi malignan, walaupun klinisnya adalah ameloblastoma biasa, dan bermetastase ke kelenjar limfe atau melalui kelenjar limfe. Perawatannya sama dengan lesi karsinoma intraoseus lainnya, tapi bila telah mengalami metastase maka prognosanya buruk. Tujuan penulisan ini adalah untuk melaporkan keberhasilan operasi reseksi segmental dan pemasangan mandible reconstructive plate (MRP) pada seorang pasien ameloblastik karsinoma. Laporan kasus pasien perempuan berusia 47 tahun datang ke poliklinik Bedah Mulut RSUP Dr. Sardjito Yogyakarta dengan keluhan utama benjolan pada rahang bawah depan sebelah bukal regio 3.3 - 4.7, tidak terasa sakit, konsistensi keras, warna sesuai dengan jaringan sekitar, ukuran 7x4x2 em, muneul kurang lebih 3 tahun yang lalu, mula-mula keeil kemudian membesar. Penatalaksanaan kasus ini adalah operasi reseksi segmental dan pemasangan MRP di bawah anestesi umum. Prognosis dubia ad bonam. Kesimpulan pada kasus ini pemasangan MRP mampu menjaga kontinuitas mandibula kanan-kiri, dan sebagai tempat perlekatan otot-otot mylohiod agar lidah tidak jatuh ke laring, serta untuk mempertahankan estetik dan fungsinya.

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Ueno, Shigeru, Kozo Mushimoto, and Rikiya Shirasu. "Prognostic evaluation of ameloblastoma based on histologic and radiographic typing." Journal of Oral and Maxillofacial Surgery 47, no. 1 (1989): 11–15. http://dx.doi.org/10.1016/0278-2391(89)90116-x.

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Amaral-Silva, Gleyson Kleber do, Celeste Sánchez-Romero, Vivian Petersen Wagner, et al. "Prognostic significance of hMSH2, hMSH3, and hMSH6 expression in ameloblastoma." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 124, no. 3 (2017): 286–95. http://dx.doi.org/10.1016/j.oooo.2017.05.511.

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Leiser, Y., I. Abu-El-Naaj, O. Ben-Izhak, and M. Peled. "O.127 The prognostic role of molecular markers in ameloblastoma." Journal of Cranio-Maxillofacial Surgery 36 (September 2008): S32. http://dx.doi.org/10.1016/s1010-5182(08)71251-4.

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Li, Yi, Bo Han, and Long-Jiang Li. "Prognostic and proliferative evaluation of ameloblastoma based on radiographic boundary." International Journal of Oral Science 4, no. 1 (2012): 30–33. http://dx.doi.org/10.1038/ijos.2012.8.

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Kim, Jue Young, Jinsun Kim, Shadavlonjid Bazarsad, In‐Ho Cha, Sung‐Won Cho, and Jin Kim. "Bcl‐2 is a prognostic marker and its silencing inhibits recurrence in ameloblastomas." Oral Diseases 25, no. 4 (2019): 1158–68. http://dx.doi.org/10.1111/odi.13070.

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Do Amaral-Silva, Gleyson Kleber, Celeste Sánchez-Romero, Manoela Domingues Martins, et al. "Expression of hMutS Proteins in Ameloblastoma Cases and Their Prognostic Potential Assessment." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 126, no. 3 (2018): e153. http://dx.doi.org/10.1016/j.oooo.2018.02.610.

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Fonseca, Felipe Paiva, Bernar Monteiro Benites, Ciro Dantas Soares, et al. "Prognostic importance of FGF2 and FGFR1 expression for patients affected by ameloblastoma." Journal of Oral Pathology & Medicine 47, no. 4 (2018): 417–24. http://dx.doi.org/10.1111/jop.12695.

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Hegab, Ayman, Mohmmad Shuman, Mohammed Abd El-Akher, and Delaram Arwlan. "Ki-67 immunohistochemical expression in mandibular ameloblastoma: A prognostic indicator for local recurrence." Open Journal of Stomatology 03, no. 09 (2013): 520–26. http://dx.doi.org/10.4236/ojst.2013.39086.

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Kumar H, Harish, Raghunandan G.C, Sunder Raj Ellur, Rakesh S Ramesh, and Diviya K Kariappa. "Surgical resection with autologous microvascular reconstruction of the mandible conferring excellent cosmesis and prognosis in ameloblastoma." IP Indian Journal of Anatomy and Surgery of Head, Neck and Brain 4, no. 4 (2020): 102–5. http://dx.doi.org/10.18231/2581-5229.2018.0027.

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Yunaev, Michael, Muzib Abdul-Razak, Hedley Coleman, Yaroslav Mayorchak, and Ian Kalnins. "A Rare Case of Ameloblastic Carcinoma." Ear, Nose & Throat Journal 93, no. 9 (2014): E34—E36. http://dx.doi.org/10.1177/014556131409300908.

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Ameloblastic carcinoma is a rare type of ameloblastoma that has received little mention in the literature. While a number of cases have been published over many years, no institution has been able to produce a substantial case series. Ameloblastic carcinoma originates in the embryonic tooth components. It is believed to be an aggressive tumor that can metastasize; once metastasis occurs, the prognosis tends to be poor. Ameloblastic carcinoma is primarily a surgical condition that is best treated with resection; there has been little indication that other modalities are helpful. We present the case of a 40-year-old woman who was found to have a mandibular lesion by a dentist. After surgical resection, the tumor was found to be an ameloblastic carcinoma. The patient recovered without complication, and she was recurrence-free 18 months postoperatively. We also briefly review the available literature on the natural history of and management options for this rare tumor.

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EVANGELOU, ZOI, ATHINA ZARACHI, JEAN MARC DUMOLLARD, et al. "Maxillary Ameloblastoma: A Review With Clinical, Histological and Prognostic Data of a Rare Tumor." In Vivo 34, no. 5 (2020): 2249–58. http://dx.doi.org/10.21873/invivo.12035.

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Yang, Yao-Cheng, Jun-Jie Wang, Yun Huang, Wei-Xin Cai, and Qian Tao. "Development and Validation of a Prognostic Nomogram for Postoperative Recurrence-Free Survival of Ameloblastoma." Cancer Management and Research Volume 13 (June 2021): 4403–16. http://dx.doi.org/10.2147/cmar.s307517.

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Yogesh, T. Lakkashetty, and S. V. Sowmya. "Granules in Granular Cell Lesions of the Head and Neck: A Review." ISRN Pathology 2011 (September 12, 2011): 1–10. http://dx.doi.org/10.5402/2011/215251.

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Granular cell lesions of the oral mucosa, jaws, and salivary glands constitute a heterogeneous group of lesions which may be either odontogenic, salivary gland, or metastatic in origin. Granular cells in these proliferations most commonly are the result of lysosomal accumulation, aging, degenerative, metabolic alteration, increased apoptosis, cytoplasmic autophagocytosis, and many more. Many benign and malignant tumors that occur in the oral cavity contain granular cells as a characteristic component of their pathology. Sometimes dilemma exists in the proper diagnosis of these granular cell lesions and the cell of origin because they share similar light and electron microscopic features. Therefore, immunohistochemistry helps to confirm histologic impressions and differentiate other neoplastic entities with granular cytoplasmic features. Granularity in a normal histopathology is a rare but innocuous change and does not influence the biologic behaviour of smooth muscle tumors except few lesions such as cutaneous granular cell angiosarcoma and granular cell ameloblastoma which have shown poor prognosis. This paper aims to review the clinical and pathologic features, different immunohistochemical profiles of granules in granular cell lesions of head and neck with an attempted working classification.

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Safadi, Rima Ahmad, Basma Faleh Qudah, and Huda Mahmoud Hammad. "Diagnostic and Prognostic Correlations of Immunohistochemical Markers in Ameloblastoma. Quantitative Analysis Using Imagej-color Deconvolution method." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 119, no. 3 (2015): e190. http://dx.doi.org/10.1016/j.oooo.2014.07.389.

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Poulet, F. M., B. A. Valentine, and B. A. Summers. "A Survey of Epithelial Odontogenic Tumors and Cysts in Dogs and Cats." Veterinary Pathology 29, no. 5 (1992): 369–80. http://dx.doi.org/10.1177/030098589202900501.

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A retrospective histologic study of 12 canine and eight feline epithelial odontogenic tumors and cysts was conducted from oral masses ( n = 3,917) obtained between 1980 and 1990. No sex or breed predilection was identified. Ameloblastoma was observed in two dogs (case Nos. 1, 2) 6 and 8 months of age. Calcifying epithelial odontogenic tumors were seen in a dog (case No. 3) and in two cats (case Nos. 4, 5) between 8 and 16 years of age. Ameloblastic fibroma (or fibroameloblastoma) was observed in cats (case Nos. 6–10) only. Inductive fibroameloblastoma was observed in four cats (case Nos. 6–9) up to 1 year of age, whereas ameloblastic fibroma was seen in a 14-year-old cat (case No. 10). A single ameloblastic odontoma was identified in a 20-month-old dog (case No. 11). Two complex odontomas occurred in a 6-month-old (case No. 12) and a 4-year-old (case No. 13) dog. Odontogenic cysts were identified in five dogs (case Nos. 14–18) aged 4.5 months to 16 years and in a 1-year-old cat (case No. 19) and have not been previously reported in these species. These cysts were lined by a stratified epithelium reminiscent of the appearance of ameloblastic epithelium. An odontogenic keratocyst with prominent central parakeratotic keratinization was identified in one 9-year-old female dog (case No. 20). Almost all epithelial odontogenic tumors were circumscribed, benign tumors that warranted a good prognosis for survival, although local recurrence may have followed (or may follow) incomplete excision. Calcifying epithelial odontogenic tumors may be locally invasive. Of six odontogenic cysts (case Nos. 14–19), two (case Nos. 15, 18) gave rise to basi-squamous carcinomas. The classification and behavior of epithelial odontogenic tumors and cysts in human beings, dogs, and cats are discussed.

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Sakshi, Sakshi, and Riya Kuklani. "Ameloblastic Fibroma: A Rare Entity of the Mandible." American Journal of Clinical Pathology 152, Supplement_1 (2019): S48. http://dx.doi.org/10.1093/ajcp/aqz113.027.

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Abstract Ameloblastic fibroma (AF) is an uncommon benign odontogenic true mixed tumor comprising neoplastic epithelial and mesenchymal tissues. It constitutes only approximately 2% of odontogenic tumors and is defined by the World Health Organization (WHO) as “neoplasm composed of proliferating odontogenic epithelium embedded in cellular ectomesenchymal tissue that resembles the dental papilla and epithelial strands and varying degrees of inductive changes and dental hard tissue formation.” The tumor is most common in the first and second decades of life with a slight male predilection. The most common site is the posterior mandible and 75% of the cases are associated with an unerupted tooth. Radiologically, it may present as a unilocular or multilocular lesion. The treatment of choice could range from aggressive curettage for a small unilocular lesion to wide local excision for a large multilocular lesion. The prognosis is usually good, with a recurrence rate of approximately 20%. Here we present a case of a 13-year-old male with a multilocular expansile cystic lesion associated with nonvital tooth 20 and tooth 21 since 2016. An incisional biopsy was performed and the microscopic examination revealed small masses of cellular fibrous and myxoid connective tissue containing long narrow cords of odontogenic epithelium. The odontogenic islands were basophilic with peripheral nuclear palisading of the basal cell layer, consistent with an ameloblastic fibroma. Complete curettage was performed and the patient is being followed up with no recurrence since 2 months. We reviewed the literature with regard to clinical, histopathological, and radiological findings and reached the conclusion that malignant transformation of ameloblastic fibroma into ameloblastic fibrosarcoma is uncommon but well documented. AF needs to be distinguished from ameloblastoma and ameloblastic fibrosarcoma, since these two tumors can be locally invasive and have greater potential for recurrence than ameloblastic fibroma.

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Safadi, Rima A., Basma F. Quda та Huda M. Hammad. "Immunohistochemical expression of K6, K8, K16, K17, K19, maspin, syndecan-1 (CD138), α-SMA, and Ki-67 in ameloblastoma and ameloblastic carcinoma: diagnostic and prognostic correlations". Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 121, № 4 (2016): 402–11. http://dx.doi.org/10.1016/j.oooo.2015.11.015.

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Nithya, S., Susmita Saxena, and Jitin Kharbanda. "Oral pediatric pathologies: Incidence and demography – An institutional study in Delhi, India." Indian Journal of Medical Sciences 71 (April 2, 2020): 104–8. http://dx.doi.org/10.25259/ijms_3_2020.

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Objective: Development and growth is at its most dynamic phase before adolescence. The increased awareness of early diagnosis having a better prognosis has led to the identification of many oral pathologies in a pediatric population. While many profiles of oral biopsies from children are available, the role of regional and geographic variations could be ascertained through periodic evaluation and data collection. The main aim of this retrospective study was to assess the distribution, frequency, and type of pediatric cases that are seen in a dental setting catering to predominantly lower socioeconomic strata of population in a region of Delhi, India. Materials and Methods: Archives of biopsies submitted to the department of oral and maxillofacial pathology were taken from the year 2012 to 2018 and all cases under the age of 13 or below were included in the study. A total of 851 archived cases were retrieved, of which 60 fulfilled our criteria for case selection. The available data were categorized into seven groups according to (1) age (0–4, 5–8, and 9–13 years), (2) sex, (3) site (area affected and intra-/extraosseous), (4) inflammatory/reactive, (5) cystic (odontogenic {inflammatory/developmental}/ non-odontogenic), (6) neoplastic ([a] odontogenic/non-odontogenic and [b] benign/malignant), and (7) others (infections). Results: The analysis showed that most of the lesions were within the 9–13 years age group (61.66%) with male gender predominance, M:F ratio being 1.6:1. The lesions were mostly extraosseous (n = 34) with mandible being commonly afflicted (36.6%). Among the pathologic cases, the lesions were mostly non-odontogenic with the mucocele appearing as the most common reactive lesion. The incidence of radicular cyst (n = 5) was found to be higher among the odontogenic cystic lesions (n = 12). One (rhabdomyosarcoma) out of 10 neoplastic lesions was malignant Benign:Malignant ratio (9:1). While ameloblastoma was seen as the common benign odontogenic tumor, the ossifying fibroma was predominant among the non-odontogenic group. Tuberculosis followed by osteomyelitis was seen to be prevalent under the category of infections. Conclusion: This study helps us to observe the common lesions or conditions afflicting children in this part of India and their association with age, sex, and site. It was found that a higher incidence of reactive lesion is present in this age group, while the neoplastic lesions are predominantly benign similar to other studies.

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Ramos, Erika Antônia dos Anjos, Fernando Amorim Mendonça Alves, Cesar Angelo Lascala, Andre Antonio James, and Eduardo Massaharu Aoki. "Efficacy of MRI in the differential diagnosis of odontogenic keratocyst: literature review." Clinical and Laboratorial Research in Dentistry, June 28, 2018. http://dx.doi.org/10.11606/issn.2357-8041.clrd.2018.142696.

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According to the World Health Organization (WHO 2017), the odontogenic keratocyst (OKC) is classified as an odontogenic developmental cyst, with origins from the cellular remnants of the dental lamina. The characteristics of a high rate of cell proliferation, relapse and aggressive growth guide the choice of the type of surgical treatment for the lesion and, consequently, the prognosis. The use of Magnetic Resonance Imaging (MRI) for the differential diagnosis of odontogenic lesions does not replace anatomopathological examination, but the types of protocols already described illustrate the influence of these different protocols on the qualitative and quantitative description of keratocysts. We conclude that magnetic resonance imaging is valid as a tool to aid diagnosis of odontogenic lesions, especially for differential diagnosis studies between odontogenic keratocysts and ameloblastomas.

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Phattarataratip, Ekarat, Tarit Panitkul, Watunyoo Khodkaew, Pattarapong Anupuntanun, Jirapat Jaroonvechatam, and Sirawit Pitarangsikul. "Expression of SOX2 and OCT4 in odontogenic cysts and tumors." Head & Face Medicine 17, no. 1 (2021). http://dx.doi.org/10.1186/s13005-021-00283-1.

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Abstract Background Aberrant expression of stem cell markers has been observed in several types of neoplasms. This trait attributes to the acquired stem-like property of tumor cells and can impact patient prognosis. The objective of this study was to comparatively analyze the expression and significance of SOX2 and OCT4 in various types of odontogenic cysts and tumors. Methods Fifty-five cases of odontogenic cysts and tumors, including 15 ameloblastomas (AM), 5 adenomatoid odontogenic tumors (AOT), 5 ameloblastic fibromas (AF), 5 calcifying odontogenic cysts (COC), 10 dentigerous cysts (DC) and 15 odontogenic keratocysts (OKC) were investigated for the expression of SOX2 and OCT4 immunohistochemically. Results Most OKCs (86.7 %) and all AFs expressed SOX2 in more than 50 % of epithelial cells. Its immunoreactivity was moderate-to-strong in all epithelial cell types in both lesions. In contrast, SOX2 expression was undetectable in AOTs and limited to the ameloblast-like cells in a minority of AM and COC cases. Most DCs showed positive staining in less than 25 % of cystic epithelium. Significantly greater SOX2 expression was noted in OKC compared with DC or AM, and in AF compared with COC or AOT. OCT4 rarely expressed in odontogenic lesions with the immunoreactivity being mild and present exclusively in OKCs. Conclusions SOX2 is differentially expressed in odontogenic cysts and tumors. This could be related to their diverse cells of origin or stages of histogenesis. The overexpression of SOX2 and OCT4 in OKC indicates the acquired stem-like property. Future studies should investigate whether the overexpression of OCT4 and SOX2 contributes to the aggressive behaviors of the tumors.

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Das, Debeswar, Priya Shree, Kumar Vishwajit, Anupama Kumari, and Satyendra Prasad Yadav. "PROLIFERATIVE POTENTIALITY OF AMELOBLASTOMA BY EXPRESSION OF Ki-67." INDIAN JOURNAL OF APPLIED RESEARCH, August 1, 2021, 29–30. http://dx.doi.org/10.36106/ijar/3001162.

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Ameloblastoma is a type of Odontogenic tumor, commonly encountered in orofacial region. It is very aggressive in nature with potential features of recurrence. Ki -67 is already a proven proliferative marker, which is used in our study to assess the proliferative potentiality of Ameloblastoma. Incisional biopsy was done from 10 cases of Ameloblastoma and 5 normal cases as control, at the department of Oral pathology and Microbiology, BIDSH, Patna. Each specimen was processed and two sections were prepared and stained with hematoxylin and eosin and Ki-67 immunohistochemical marker. Positive stained cells with with Ki-67 in ameloblastoma along with normal epithelium were counted from four randomly selected areas and were quantied using a microscope at 400x magnication. Positive correlation seen with Ki-67 positive cells and percentages, which indicates the value of one variable increases, the other also increases. The overall conclusion is that Ki-67 expression can be used as a prognostic marker in Ameloblastoma.

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Yang, X., K. Zhou, Y. Tao, S. Ge, W. Shang, and K. Song. "Treatment efficacy and prognosis of pulmonary metastasizing ameloblastoma: a systematic review." International Journal of Oral and Maxillofacial Surgery, August 2021. http://dx.doi.org/10.1016/j.ijom.2021.07.016.

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Tenório, Jefferson Rocha, Solange Kobayashi-Velasco, Fábio Daumas Nunes, and Marcelo Gusmão Paraiso Cavalcanti. "Radiographic imaging pattern of ossifying fibroma mimicking ameloblastoma." Clinical and Laboratorial Research in Dentistry, April 23, 2019. http://dx.doi.org/10.11606/issn.2357-8041.clrd.2019.152635.

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Radiographic examinations complement the anamnesis and physical exam with the purpose of reaching diagnosis, prognosis and treatment planning. In this case report, a 48 year-old male Caucasian patient was referred to an oral and maxillofacial surgeon by a general practitioner after a panoramic radiography for treatment planning; the implant surgery follow-up portrayed a multilocular radiolucent image at the left posterior mandible. Based solely on the panoramic radiography, the diagnostic hypothesis was ameloblastoma. The surgeon decided to perform an incisional biopsy. However, during the procedure, the professional noted that the lesion was easily detached from the adjacent bone and opted for the total removal of the lesion, thus altering its diagnostic hypothesis to central ossifying fibroma (COF). The histopathological result confirmed the diagnostic hypothesis provided by the surgeon, i.e. COF. Although multilocular presentation is not common, COF should be considered in the scope of multilocular radiolucent lesions of the jaws. In addition, computerized tomography imaging exam complemented by surgical and histopathological aspects should be considered for establishing the final diagnosis and conducting the therapeutic approach.

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Hosalkar, R., T. S. Saluja, N. Swain, and S. K. Singh. "Prognostic evaluation of metastasizing ameloblastoma: A systematic review of reported cases in literature." Journal of Stomatology, Oral and Maxillofacial Surgery, July 2020. http://dx.doi.org/10.1016/j.jormas.2020.07.001.

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Journal articles on the topic 'Prognosis ameloblastomas'

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