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1

Leckey, Joan Lesley. Urinary and tumour markers of disease recurrence and prognosis in transitional cell carcinoma of the bladder. The Author], 1997.

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2

Naess, Halvor. Long-term prognosis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198722366.003.0016.

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Knowledge of prognosis is important for patients in the prime of life in order to make informed decisions about treatment, choice of education, and profession. Median first-year mortality after first-ever cerebral infarction among young adults is about 4% while median annual average mortality after the first year is about 1.7%. Likewise, median first-year recurrence rate of cerebral infarction is 2% and thereafter 1.5% per year. Risk factors for recurrent cerebral infarction include hypertension, diabetes mellitus, symptomatic atherosclerosis, and smoking. Recurrent cerebral infarction and mor
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3

Role of Obesity in Cancer Survival and Recurrence: Workshop Summary. National Academies Press, 2012.

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4

Klimo, Paul, and Nir Shimony. Ependymomas. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0026.

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Pediatric posterior fossa tumors are usually ependymoma, pilocytic astrocytoma, or medulloblastoma. Ependymoma appears well-demarcated with heterogeneous enhancement on magnetic resonance imaging (MRI). Full neural axis MRI is indicated to assess for metastatic disease. Management is typically surgical resection of the tumor, with consideration for cerebrospinal fluid diversion if patients present with severe hydrocephalus. Extent of resection of the tumor is the most important factor in predicting recurrence and overall survival, and gross total resection is ideal. Infratentorial ependymomas
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5

Huntoon, Kristin, and J. Bradley Elder. High-Grade Gliomas. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0001.

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Glioblastoma is the most common primary malignant brain tumor. This chapter discusses the clinical presentation and initial workup for a patient with a suspected glioblastoma, as well as the optimal treatment strategy and prognosis. Diagnosis is typically made using magnetic resonance imaging. Optimal treatment involves maximal safe surgical resection followed by adjuvant chemotherapy and radiation therapy. Surgical adjuncts including intraoperative imaging modalities and brain mapping techniques help improve neurologic morbidity associated with surgery. Despite maximal treatment, virtually al
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6

Ball, Steve, and Sajid Kalathil. Adrenocortical cancer. Edited by James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0094.

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Adrenocortical cancer (ACC) is rare and associated with poor prognosis. The incidence is estimated at 0.7–2 cases per one million. Overall survival rate at five years for ACC is 37–47%. While the pathogenesis of ACC is incompletely understood, inherited predisposition syndromes are common in childhood ACC. Clinical presentation can be with symptoms and signs of hormone excess (functional tumours), mass effects, or as an incidental radiological finding. A multidisciplinary approach combining radiology, biochemistry, and tissue-based pathology is needed to establish a diagnosis to guide a surgic
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7

Schapira, Lidia, and Lauren Goldstein. Dealing with cancer recurrence. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198736134.003.0020.

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When patients conclude active cancer therapy, many experience an elevated degree of awareness and worry about disease recurrence. For most patients, this anxiety is intermittent and tolerable, but for others, it is quite disruptive. Patients’ psychological and cognitive difficulties are not systematically explored during routine medical visits. Receiving the news of cancer recurrence is enormously difficult and so is the disclosure of news for the oncologist. The chapter provides practical tips for disclosing prognostic information. Physicians can and should pay particular attention to patient
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8

Vranckx, Pascal, Wilfried Mullens, and Johan Vijgen. Non-pharmacological therapy of acute heart failure: when drugs alone are not enough. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199687039.003.0053.

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Acute heart failure syndrome has been defined as new-onset or a recurrence of worsening signs and symptoms of heart failure, necessitating urgent or emergency management. The management of acute heart failure syndrome is challenging, given the heterogeneity of the patient population, in terms of the clinical presentation, pathophysiology, prognosis, and therapeutic options. The management of acute heart failure syndrome is a dynamic process, requiring ongoing simultaneous diagnosis (monitoring) and treatment. Pharmacological agents remain the mainstay of therapy for acute heart failure syndrom
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9

Kissane, David W., Barry D. Bultz, Phyllis N. Butow, Carma L. Bylund, Simon Noble, and Susie Wilkinson, eds. Oxford Textbook of Communication in Oncology and Palliative Care. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198736134.001.0001.

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This textbook integrates clinical wisdom with empirical findings, drawing upon the history of communication science, providing a comprehensive curriculum for applied communication skills training for specialist oncologists, surgeons, nurses, psychosocial care providers and other members of the multidisciplinary team. This new edition presents a curriculum for nurses, which discusses needs of pre-registration to advanced trainees, including the ‘SAGE & THYME’ training programme, chronic disease, responding to depressed patients, the last hours and days of life, family care, facilitation tra
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10

Cui, Zhao, Neil Turner, and Ming-hui Zhao. Antiglomerular basement membrane disease. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0073_update_001.

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Cyclophosphamide and plasma exchange are the standard of care in rapidly progressive glomerulonephritis or lung haemorrhage caused by antiglomerular basement membrane (anti-GBM) disease, and it is unusual to encounter patients at earlier stages. Steroids are universally used in addition. There is some evidence that plasma exchange may not be a critical part of treatment at an earlier stage. There is no more than anecdotal evidence for other therapies. Slower-onset therapies such as antibodies to B cells are rarely appropriate. If untreated, patients with severe anti-GBM disease will not recove
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11

Boro, Alex, and Jerome Engel. Clinical Presentation, Diagnosis, and Course: Epilepsy Syndromes with Focal Seizures. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0043.

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The epilepsies are a common and often devastating group of diseases characterized by recurrent seizures and coexisting conditions including cognitive, emotional, and behavioral comorbidities. These diseases affect about 1% of the population worldwide. About 60% of patients with epilepsy have focal seizures. The goal of this chapter is to describe the clinical presentation, epidemiology, and prognosis of the epilepsy syndromes characterized by focal seizures. The biological bases of these diseases and their management are explored in detail in other chapters in this volume.
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12

Bäumer, Dirk. Seizures. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0042.

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Seizures are transient neurological events caused by abnormal excessive or synchronous neuronal activity in the brain. This can arise from a localized brain region, causing focal seizures, or simultaneously from both hemispheres, leading to generalized seizures. Epilepsy is the tendency to develop recurrent seizures and is usually diagnosed after two or more unprovoked seizures. This chapter covers simple partial seizures (sometimes called aura), complex partial seizures, and focal (or partial) seizures, their differential diagnosis, context, approach to diagnosis, key diagnostic tests, therap
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13

Kaley, Thomas J. Oligodendrogliomas. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0128.

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Gliomas represent the most common symptomatic primary brain tumors, of which oligodendrogliomas are the least common subtype of glioma.1 The traditional thinking is that although the rarest, they also offer patients the best prognosis and they are deemed to be the most sensitive to treatment. However, although they may have a longer average survival than most other gliomas, nearly all patients with an oligodendroglioma will ultimately succumb to their illness due to either progressive and recurrent tumor or malignant transformation into a higher grade tumor. Optimal treatment of oligodendrogli
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14

Zanarini, Mary. In the Fullness of Time. Oxford University Press, 2018. http://dx.doi.org/10.1093/med-psych/9780195370607.001.0001.

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Borderline personality disorder (BPD) is still seen in many settings as a chronic disorder. This book details the ways that it is symptomatically a “good prognosis” diagnosis. This is particularly seen in the high rate of remissions of BPD and its constituent symptoms. The rate of suicide is also good news, as it is half the expected rate from four follow-back studies conducted in the 1980s. Areas with a more guarded prognosis, particularly for those who have not recovered, are poor physical health and poor vocational adjustment. In addition, rates of other deaths are increasing and have surpa
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15

Olsen, Jan Abel. The healthcare delivery system: an overview. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198794837.003.0013.

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This chapter provides an overview of the healthcare delivery system. A figure illustrates how six different parts of the system relate to each other. The primary care level plays a key role in many countries by representing the gate, in which referrals to secondary care are being made. Tertiary care is principally of two types depending on patients’ prognosis: chronic care or rehabilitation. In addition to the three care levels, there are two parts with quite different roles: pharmacies provide pharmaceuticals, and sickness benefit schemes compensate the sick for their income losses. A recurre
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16

Bryant, Richard J., and James W. F. Catto. General overview of bladder cancer. Edited by James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0074.

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Bladder cancer (BC) is a common malignancy and is one of the most expensive to manage. This tumour typically affects middle-aged and elderly patients and is more common in men. These demographics reflect the aetiological links between BC and tobacco smoking and occupational exposure to carcinogens. While the presenting symptom of BC is usually painless visible haematuria, around one-quarter of tumours present with irritative voiding symptoms, recurrent or antibiotic-refractory urinary tract infections, non-visible haematuria, or are found by chance during the investigation of unrelated symptom
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17

Scott-Brown, Martin. Dying from cancer. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0330.

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For many patients, dying from cancer has been an ever-present reality from the time they were diagnosed with incurable recurrent or metastatic cancer. Treatment may have delayed the inevitable, but there does come a point where aggressive management no longer improves the prognosis or can only prolong life that is of such a poor quality that it is not valued by the patient. It sometimes is easier to continue with treatment than to take the time with the patient to discuss the reasons why further treatment is not appropriate. For patients with advanced cancer and whose condition is deterioratin
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18

AlJaroudi, Wael. Myocardial Perfusion Imaging Before and After Cardiac Revascularization. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199392094.003.0015.

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Coronary artery disease (CAD) remains the leading cause of morbidity and mortality worldwide. While the burden of the disease remains high, the rates of death attributable to CAD have declined by almost a third between 1998 and 2008. In patients with stable ischemic heart disease (SIHD), data supporting survival benefit from coronary artery bypass graft surgery (CABG) or percutaneous coronary intervention (PCI) versus no revascularization are outdated with the recent advancement in medical therapy. Over the years, myocardial perfusion imaging (MPI) has played a significant role in detecting is
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19

Alchi, Bassam, and David Jayne. The patient with antiphospholipid syndrome with or without lupus. Edited by Giuseppe Remuzzi. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0164.

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Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent arterial or venous thrombosis and/or pregnancy loss, accompanied by laboratory evidence of antiphospholipid antibodies (aPL), namely anticardiolipin antibodies (aCL), lupus anticoagulant (LA), and antibodies directed against beta-2 glycoprotein 1 (β‎‎‎2GP1). APS may occur as a ‘primary’ form, ‘antiphospholipid syndrome,’ without any known systemic disease or may occur in the context of systemic lupus erythematosus (SLE), ‘SLE-related APS’. APS may affect any organ system and displays a broad spectrum of thromb
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20

Lambert, Heather. Primary vesicoureteric reflux and reflux nephropathy. Edited by Adrian Woolf. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0355_update_001.

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Vesicoureteric reflux (VUR) describes the flow of urine from the bladder into the upper urinary tract when the ureterovesical junction fails to perform as a one-way valve. Most commonly, VUR is primary, though it can be secondary to bladder outflow obstruction and can occur in several multiorgan congenital disorders. There is good evidence of a genetic basis with a greatly increased risk of VUR in children with a family history of VUR. VUR is a congenital disorder, which largely shows improvement or complete resolution with age. Fetal VUR may be associated with parenchymal developmental defect
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21

AlJaroudi, Wael. Risk Assessment in Acute Coronary Syndromes. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199392094.003.0013.

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Acute coronary syndromes (ACS) include unstable angina pectoris (UAP), non-ST elevation (NSTEMI), and ST elevation acute myocardial infarction (STEMI). Each year, more than 2 million people are hospitalized with ACS in the United States. The initial treatment has evolved over the last few decades from conservative management to early reperfusion therapy. Medical therapy has also significantly changed with the use of newer more potent antiplatelet agents, beta-blockers, angiotensin converting enzyme inhibitors, statins, and anti-anginal drugs, which have resulted in improvement of patient care
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