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Dissertations / Theses on the topic 'Prognosis e recurrence'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Pennlert, Johanna. "Recurrent stroke : risk factors, predictors and prognosis." Doctoral thesis, Umeå universitet, Medicin, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127304.

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Background Many risk factors for stroke are well characterized and might, at least to some extent, be similar for first-ever stroke and for recurrent stroke events. However, previous studies have shown heterogeneous results on predictors and rates of stroke recurrence. Patients who survive spontaneous intracerebral hemorrhage (ICH) often have compelling indications for antithrombotic (AT) treatment (antiplatelet (AP) and/or anticoagulant (AC) treatment), but due to controversy of the decision to treat, a large proportion of these patients are untreated. In the absence of evidence from randomiz

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2

Durkan, Garrett Christopher. "Matrix metalloproteinase-1 and -9 and tissue inhibitor of metalloproteinase-1 in bladder cancer : pathophysiological significance and relationship to epidermal growth factor receptor expression." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369832.

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3

Leckey, Joan Lesley. "Urinary and tumour markers of disease recurrence and prognosis in transitional cell carcinoma of the bladder." Thesis, University of Ulster, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310119.

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4

Huhtakangas, J. (Juha). "The influence of medication on the incidence, outcome, and recurrence of primary intracerebral hemorrhage." Doctoral thesis, Oulun yliopisto, 2012. http://urn.fi/urn:isbn:9789514299438.

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Abstract Intracerebral hemorrhage (ICH) is the most pernicious form of stroke, with high mortality. Warfarin-associated ICH (WA-ICH) carries an even higher mortality rate. The major reason for the high mortality is explained by early hematoma growth. Warfarin use has rapidly increased with the aging of the population. We investigated temporal trends in the incidence and outcome of WA-ICHs. We found that although the proportion of warfarin users almost quadrupled in our population, the annual incidence and case fatality of WA-ICHs decreased. Management of ICH is mostly supportive. Prevention of

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5

Teixeira, Roberto Augusto Plaza. ""Fatores clínicos e biológicos para recidivas em tumores de Wilms localizados"." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-04012006-105538/.

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Apesar do excelente prognóstico dos tumores de Wilms (TW) localizados (estádios I e II) e de histologia favorável (HF), 10% deles recidivam. Em 122 pacientes com TW com essas características, diagnosticados de 1976 e 2001, analisamos alguns fatores clínicos, como a idade por ocasião do diagnóstico e peso do tumor, em todos os pacientes; fatores biológicos, como o TP53 e a glicoproteína-p, em 40 deles; e variáveis histológicas de microestadiamento (invasão de seio renal, cápsula tumoral, vasos intra-renais e pseudocápsula inflamatória) em 28 com TW em estádio I. Correlacionando todos esses fato

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6

Sena, Marina Fernandes de. "Recidiva de c?ncer labial em pacientes atendidos no Hospital Dr. Luiz Ant?nio (Natal-RN) entre 1997-2004." Universidade Federal do Rio Grande do Norte, 2009. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17052.

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Made available in DSpace on 2014-12-17T15:30:53Z (GMT). No. of bitstreams: 1 MarinaFS.pdf: 587515 bytes, checksum: 475e3de91c334287e77aaef918353e42 (MD5) Previous issue date: 2009-03-26<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>Introduction: Cancer of the lip is very common in tropical countries, being noticeable the squamous cell carcinoma as the main histological type. Objective: Evaluate the socialdemographic profile, habits, occupation, clinical characteristics of the cancer lesions and the aftermath of treatment of the patients treated on the Luiz Ant?nio Hospi

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7

Viana, Aline de Oliveira Ribeiro. "Expressão de marcadores moleculares preditivos de recorrência locoregional de carcinoma papilífero de tireoide." Universidade de São Paulo, 2019. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-21032019-092957/.

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INTRODUÇÃO: O carcinoma papilífero é o tumor maligno mais comum da tireoide e sua incidência vem aumentando em todo o mundo nas últimas décadas. A maioria dos pacientes com carcinoma papilífero apresenta bom prognóstico, com uma taxa de sobrevida em 10 anos de 90 a 95%, porém, as taxas de recorrência e a necessidade de continuar o tratamento continuam a ser um problema significativo para 5 a 40% dos pacientes. Embora sejam utilizadas diversas classificações de risco baseadas em diferentes fatores prognósticos, nenhuma é capaz de predizer quais pacientes terão maior chance de recorrência e desf

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Chagas, Aline Lopes. "Avaliação da recidiva do carcinoma hepatocelular em pacientes submetidos a transplante de fígado no Brasil." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-30012018-121035/.

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INTRODUÇÃO: O transplante (TX) de fígado corresponde ao tratamento de escolha em pacientes com cirrose e carcinoma hepatocelular (CHC) precoce irressecável. A recidiva do CHC pós-transplante, entretanto, ainda apresenta impacto na sobrevida dos pacientes transplantados com este tumor. As taxas de recidiva, nos estudos mais recentes, variam de 8 a 20%. O tamanho e número de nódulos, a presença de invasão vascular e de nódulos satélites no explante, são fatores de risco relacionados à recidiva tumoral pós-transplante. No Brasil, observamos um crescimento importante do número de transplantes de f

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9

Junior, Mituro Hattori. "Fatores prognósticos em carcinomas de glândulas salivares recidivados submetidos à cirurgia de resgate." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-13022008-105752/.

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Carcinomas de glândulas salivares são raros e seu tratamento de escolha é cirúrgico, seguido ou não de radioterapia. Até 50% dos casos apresentam recorrências neoplásicas e a maioria delas é local. O único tratamento de resgate com potencial curativo é o cirúrgico. No entanto, poucos estudos abordam o tema. O objetivo deste estudo é avaliar a ocorrência de complicações cirúrgicas e os fatores prognósticos clínicos e anatomopatológicos em pacientes portadores de carcinoma de glândulas salivares recidivado, submetidos à cirurgia de resgate. Foram avaliados 59 pacientes que preenchiam os critério

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10

Vicente, Carolina de Jesus Pardal. "Avaliação de fatores de risco para a evolução clínica e prognóstico a curto e longo prazo de hérnias perineais : estudo retrospetivo em 75 animais da espécie Canis familiaris." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2018. http://hdl.handle.net/10400.5/16431.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>Hérnia perineal é uma entidade clínica reconhecida em várias espécies, especialmente no cão macho não castrado de idade adulta a avançada, surgindo por enfraquecimento e separação dos componentes do diafragma pélvico, o que permite a passagem de estruturas entre eles. Pensa-se que se trate de uma entidade de etiologia multifatorial, tendo sido implicados diversos fatores: atrofia dos músculos do diafragma pélvico, alterações retais, desequilíbrios hormonais, excesso de pressão no diafragma pélvico e efeito da relaxina prostátic

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11

TAKAHASHI, HIROSHI, CHISA HASHIZUME, TAKAHIKO TSUGAWA, YOSHIMASA MORI, and TATSUYA KOBAYASHI. "PROGNOSTIC FACTORS FOR TUMOR RECURRENCE AFTER GAMMA KNIFE RADIOSURGERY OF PARTIALLY RESECTED AND RECURRENT CRANIOPHARYNGIOMAS." Nagoya University School of Medicine, 2012. http://hdl.handle.net/2237/16031.

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12

Prasanna, Prateek. "NOVEL RADIOMICS FOR SPATIALLY INTERROGATING TUMOR HABITAT: APPLICATIONS IN PREDICTING TREATMENT RESPONSE AND SURVIVAL IN BRAIN TUMORS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case149624929700524.

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13

Felga, Guilherme Eduardo Gonçalves. "Análise dinâmica de sobrevida conforme dados do Inquérito Nacional de Carcinoma Hepatocelular e Transplante de Fígado." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-28092018-100737/.

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INTRODUÇÃO: Enquanto a análise de sobrevida tradicional estima inadequadamente o prognóstico futuro dada alguma sobrevida inicial, a sobrevida condicional ajusta a sobrevida futura pela já observada, permitindo a compreensão da distribuição temporal do impacto dos preditores. OBJETIVOS: Estimar e analisar as sobrevidas global e livre de doença até o décimo ano pós-operatório; identificar preditores independentes destes desfechos; estimar e analisar as sobrevidas condicionais global e livre de doença de cinco anos dada a sobrevida até o quinto ano pós-operatório; analisar o comportamento dos pr

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14

Silva, Bruno de Santana. "Infiltrados eosinofílico e linfocítico em carcinoma espinocelular de lábio como fatores prognósticos." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-06102014-095129/.

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O carcinoma espinocelular de lábio (CEC) é uma patologia relativamente freqüente e acomete preferencialmente indivíduos de pele clara e com antecedentes de exposição solar. A localização labial do CEC está associada ao comportamento clínico mais agressivo. Algumas características clínicas e histológicas, como tamanho do tumor, grau de diferenciação, espessura, invasão perineural e perivascular, atuam como fatores prognósticos do CEC de lábio. A presença do infiltrado inflamatório vem sendo associada ao comportamento de diversos tumores, dentre eles o CEC. Esse infiltrado é composto por linfóci

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15

Liu, Lin, Karen Messer, John A. Baron, et al. "A prognostic model for advanced colorectal neoplasia recurrence." SPRINGER, 2016. http://hdl.handle.net/10150/621531.

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Following colonoscopic polypectomy, US Multisociety Task Force (USMSTF) guidelines stratify patients based on risk of subsequent advanced neoplasia (AN) using number, size, and histology of resected polyps, but have only moderate sensitivity and specificity. We hypothesized that a state-of-the-art statistical prediction model might improve identification of patients at high risk of future AN and address these challenges. Data were pooled from seven prospective studies which had follow-up ascertainment of metachronous AN within 3-5 years of baseline polypectomy (combined n = 8,228). Pooled data

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Pereira, Samira Luisa dos Apóstolos. "Estudo prospectivo da mielite transversa longitudinalmente extensa: análise dos fatores clínicos, laboratoriais e imagenológicos." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-30042013-092208/.

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ntrodução: A mielite transversa longitudinal extensa (MTLE), uma forma grave de síndrome medular (SM) inflamatória associada à lesão da medula espinhal (LME) propagada por três ou mais segmentos vertebrais (SV) à ressonância magnética (RM), é considerada um espectro da neuromielite óptica (ENMO). A neuromielite óptica (NMO), caracterizada por episódios graves e recorrentes de neurite óptica e mielite, é associada a um anticorpo específico, direcionado contra a aquaporina-4 (AQP4-IgG), presente em cerca de 80% dos casos da NMO e 40% dos casos de MTLE isolada. O uso de terapia imunossupressora d

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17

Marija, Jelić. "Ispitivanje 8-hidroksi-2-deoksiguanozina, produkata lipidne peroksidacije i aktivnosti antioksidativnih enzima kod prekanceroznih lezija i u karcinomu grlića materice." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=110296&source=NDLTD&language=en.

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U organizmu se, pod fiziolo&scaron;kim uslovima, produkuju slobodni radikali. Iako se u organizmu nalaze u veoma niskoj koncentraciji, slobodni radikali mogu ispoljiti toksične efekte. Težeći da spare elektrone, u hemijskoj reakciji oksidacije, dolazi do brzog i nepredvidivog vezivanja za susedne molekule, proteine, lipide, ugljene hidrate i nukleinske kiseline od kojih su sačinjeni strukturni elementi ćelije, pokrećući unutra&scaron;nji put apoptoze. Antioksidansi su supstance koje sprečavaju ili značajno smanjuju oksidaciju biomolekula. Oksidativni stres je stanje koje nastaje kada produkcij

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18

Gunnarsson, Cecilia. "Steroid converting enzymes in breast cancer /." Linköping : Univ, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med908s.pdf.

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19

Varghese, Robin. "Novel Prognostic Markers and Therapeutic Targets for Glioblastoma." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/71420.

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Glioblastoma is the most common and lethal malignant brain tumor with a survival rate of 14.6 months and a tumor recurrence rate of ninety percent. Two key causes for glioblastomas grim outcome derive from the lack of applicable prognostic markers and effective therapeutic targets. By employing a loss of function RNAi screen in glioblastoma cells we found a list of 20 kinases that can be considered glioblastoma survival kinases. These survival kinases which we term as survival kinase genes, (SKGs) were investigated to find prognostic markers as well as therapeutic targets for glioblastoma. Ana

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20

Folkvaljon, Yasin. "Prognostic value of the ISUP 2015 Gleason grade groupings." Thesis, Uppsala universitet, Statistiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-256158.

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Background: New prognostic grade groupings were recently proposed for prostate cancer. They are based on Gleason grading of either biopsy or prostatectomy specimen. Former Gleason 6 corresponds to group 1, Gleason 7=3+4 corresponds to group 2, Gleason 7=4+3 corresponds to group 3, Gleason 8 corresponds to group 4, and Gleason 9-10 correspond to group 5. Objective: To assess the prognostic value of Gleason grade groups in men with prostate cancer from a nationwide population‑based cohort. Design, Setting and Participants: From the National Prostate Cancer Register of Sweden, we identified 5,880

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21

Puente, Baliarda Diana. "Diferències entre dones i homes en el càncer de bufeta urinària: etiologia, clínica i pronòstic." Doctoral thesis, Universitat Pompeu Fabra, 2005. http://hdl.handle.net/10803/7106.

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La present tesi avalua les diferències entre homes i dones quant a les característiques sociodemogràfiques i clínicopatològiques, procés diagnòstic, tractament i pronòstic en una sèrie de casos diagnosticats de novo de càncer de bufeta en 18 hospitals de 5 regions espanyoles (estudi EPICURO). També s'estudia l'associació entre tabac i risc de càncer de bufeta segons el sexe en un estudi agregat d'estudis cas-control europeus i nord-americans de càncer de bufeta.<br/>Es trobaren diferències entre sexes quant a la incidència de la malaltia, en algunes característiques anatomopatològiques dels tu

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Jahkola, Tiina. "Tenascin-C in early breast cancer : a prognostic study of metastasis and local recurrence." Helsinki : University of Helsinki, 1999. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/jahkola/.

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23

Dempsey, Mary Frances. "Assessing prognosis and response to therapy using contrast enhanced MRI in recurrent malignant glioma." Thesis, University of Glasgow, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433068.

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24

Rafla, Mona Helmy. "Cancer de la vessie avec schistosomiase : modeles pronostiques de recidive et leur evaluation." Paris 7, 1987. http://www.theses.fr/1987PA077149.

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25

Leong, Kai Juen. "Development of epigenetic-based prognostic biomarkers to stratify risk of recurrence in early rectal cancer." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4680/.

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Organ-preservation surgery for early rectal cancer is an alternative treatment to conventional radical surgery that offers comparable oncological outcome but has lower morbidity and mortality. The efficacy of this strategy relies on accurate preoperative staging of mesorectal nodal metastasis which current staging modalities are unable to deliver. DNA methylation has a prognostic role in colorectal carcinogenesis and may select for tumours suitable for local excision, although this has not been explored in rectal cancer. A panel of staged rectal cancers was analysed for differential DNA methyl

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26

Irewall, Anna-Lotta. "Recurrent events and secondary prevention after acute cerebrovascular disease." Doctoral thesis, Umeå universitet, Medicin, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-130505.

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Background Patients who experience a stroke or transient ischemic attack (TIA) are at high risk of recurrent stroke, but little is known about temporal trends in unselected populations. Reports of low adherence to recommended treatments indicate a need for enhanced secondary preventive follow-up to achieve the full potential of evidence-based treatments. In addition, socioeconomic factors have been associated with poor health outcomes in a variety of contexts. Therefore, it is important to assess the implementation and results of secondary prevention in different socioeconomic groups. Aims The

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27

Abgral, Ronan. "Tomographie par émission de positons au 18F-fluorodesoxyglucose et carcinome épidermoïde des voies aérodigestives supérieures réfractaire au traitement." Phd thesis, Université de Bretagne occidentale - Brest, 2013. http://tel.archives-ouvertes.fr/tel-00952418.

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Nous avons initialement réalisé une étude prospective évaluant l'intérêt de la TEP-TDM au FDG pour le diagnostic de récidive infra-clinique des carcinomes épidermoïdes des voies aéro-digestives supérieures. Nos résultats ont montré d'excellentes performances de l'examen en surveillance systématique, permettant notamment le diagnostic de récidive chez environ 1/3 des patients cliniquement asymptomatiques 1 an après la fin du traitement. Nous avons ensuite étudié le bénéfice d'une évaluation thérapeutique précoce par TEP-TDM au FDG à 2 cures d'une chimiothérapie néoadjuvante par TPF précédant un

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Mettu, Ramakanth Reddy. "Constructing gene expression based prognostic models to predict recurrence and lymph node metastasis in colon cancer." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=6015.

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Thesis (M.S.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains xiv, 126 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 123-126).

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Ivana, Kolarov Bjelobrk. "Klinička vrednost određivanja prisustva tumor infiltrišućih limfocita u bolesnica sa karcinomom dojke." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=96484&source=NDLTD&language=en.

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UVOD: Glavni problem u lečenju karcinoma dojke je kako na osnovu kliničke klasifikacije i morfolo&scaron;kih osobina tumora predvideti njegovo dalje pona&scaron;anje. Vrlo često ni kombinacija standardnih prognostičkih faktora ne daje odgovor o potrebi davanja adjuvantne hemioterapije. U cilju sprovođenja adekvatne dalje terapije karcinoma dojke i otkrivanja agresivnih tipova tumora, a nakon hirur&scaron;kog lečenja, postoji stalna potreba za pronalaženjem novih pokazatelja pomoću kojih bi se identifikovale bolesnice koje imaju povećan rizik od razvoja relapsa bolesti. CILJEVI: Ciljevi su bili

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Tanja, Lakić. "Klinička vrednost određivanja Ki-67 proliferativnog indeksa u karcinomima dojke sa pozitivnim hormonskim receptorima." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2018. https://www.cris.uns.ac.rs/record.jsf?recordId=107631&source=NDLTD&language=en.

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<b>Uvod: </b>Karcinom dojke je heterogena bolest koju karakteri&scaron;u različita morfologija, imunohisto-hemijski profil, klinički tok i terapijski odgovor. Ki-67 proliferativni indeks je jedan od markera sa prognostičkim i prediktivnim značajem, čije metodolo&scaron;ko određivanje i analiza jo&scaron; uvek nisu standardizovani. <b>Cilj: </b>Utvrditi graničnu (“cut-off”) prognostičku vrednost Ki-67 indeksa, kao i povezanost vrednosti Ki-67 u ranom luminalnom karcinomu dojke sa prognostičkim i prediktivnim parametrima karcinoma dojke, kao &scaron;to su životna dob bolesnica, velič

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Schreinemakers, Jennifer, Menno Vriens, Nuria Munoz-Perez, et al. "Fluorodeoxyglucose-positron emission tomography scan-positive recurrent papillary thyroid cancer and the prognosis and implications for surgical management." BioMed Central, 2012. http://hdl.handle.net/10150/610263.

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BACKGROUND:To compare outcomes for patients with recurrent or persistent papillary thyroid cancer (PTC) who had metastatic tumors that were fluorodeoxyglucose-positron emission tomography (FDG-PET) positive or negative, and to determine whether the FDG-PET scan findings changed the outcome of medical and surgical management.METHODS:From a prospective thyroid cancer database, we retrospectively identified patients with recurrent or persistent PTC and reviewed data on demographics, initial stage, location and extent of persistent or recurrent disease, clinical management, disease-free survival a

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Nenad, Šolajić. "Prognostički značaj gustine tumorskih pupoljaka i citoplazmatskih pseudofragmenata u tumorskom tkivu karcinoma kolona kod bolesnika u stadijumu II." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=101547&source=NDLTD&language=en.

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UVOD: Karcinom kolona (KK) je velik javnozdravstveni problem usled visoke incidence i stope mortaliteta. Kod KK je stadijum bolesti najvažniji pojedinačni nezavisni faktor prognoze. U prisustvu nepovoljnih prognostičkih parametara, u koje spadaju visok histolo&scaron;ki gradus, ileus, limfo-vaskularna i perineuralna invazija, nakon potencijalno kurativne operacije se kod pacijenata u stadijumu II indikuje primena adjuvantne hemioterapije koja ima pozitivan uticaj na ukupno preživljavanje i na produženje perioda bez bolesti. Međutim, relapsi bolesti nastaju kod nekih bolesnika bez negativnih pr

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Mauguen, Audrey. "Prognosis of cancer patients : input of standard and joint frailty models." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0240/document.

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La recherche sur le traitement des cancers a évolué durant les dernières années principalement dans une direction: la médecine personnalisée. Idéalement, le choix du traitement doit être basé sur les caractéristiques dupatient et de sa tumeur. Cet objectif nécessite des développements biostatistiques, pour pouvoir évaluer lesmodèles pronostiques, et in fine proposer le meilleur. Dans une première partie, nous considérons le problèmede l’évaluation d’un score pronostique dans le cadre de données multicentriques. Nous étendons deux mesuresde concordance aux données groupées analysées par un modè

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Cruzado-Sanchez, Deivy, Walter Andree Tellez, Beltran Villarreal-Aguilar, et al. "Conjunctival squamous cell carcinoma: Prognostic factors for the recurrence and metastasis and clinicopathological characteristics at an oncological hospital in Peru." BMJ Publishing Group, 2020. http://hdl.handle.net/10757/654909.

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Background/aims Conjunctival squamous cell carcinoma (CSCC) is the most frequent malignant tumour of the conjunctiva, with scarce recurrence and infrequent metastasis. The purpose of this study is to describe the clinical and pathological characteristics of this neoplasm and to identify the prognostic factors for recurrence and metastasis in a cancer hospital in Peru. Materials and method A longitudinal, retrospective study of 176 consecutive patients diagnosed with SCC of the conjunctiva. Sociodemographic and clinical characteristics were evaluated. In addition, Kaplan-Meier curves were perfo

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Baneshi, Mohammad Reza. "Statistical models in prognostic modelling with many skewed variables and missing data : a case study in breast cancer." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4191.

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Prognostic models have clinical appeal to aid therapeutic decision making. In the UK, the Nottingham Prognostic Index (NPI) has been used, for over two decades, to inform patient management. However, it has been commented that NPI is not capable of identifying a subgroup of patients with a prognosis so good that adjuvant therapy with potential harmful side effects can be withheld safely. Tissue Microarray Analysis (TMA) now makes possible measurement of biological tissue microarray features of frozen biopsies from breast cancer tumours. These give an insight to the biology of tumour and hence

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Weinberg, Lori Elizabeth. "Lymphovascular space invasion is an isolated poor prognostic factor for recurrence and survival among women with intermediate to high-risk early stage endometrioid endometrial cancer: An exploratory retrospective cohort study." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1339205202.

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Shinozuka, Ken. "Effectiveness of Radiofrequency Ablation of Initial Recurrent Hepatocellular Carcinoma after Hepatectomy: Long-Term Results and Prognostic Factors." Kyoto University, 2018. http://hdl.handle.net/2433/231012.

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Cordovil, Teresa Mota. "Uveíte recorrente equina e leptospirose : estudo de variáveis em cavalos sujeitos a vitrectomia, na região de Hannover." Master's thesis, Universidade de Lisboa. Faculdade de Medicina Veterinária, 2013. http://hdl.handle.net/10400.5/6208.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>A uveíte recorrente equina (URE) é frequentemente citada como a causa mais comum de cegueira em cavalos, apresentando prevalências entre 8 a 10% na Europa e entre 2% a 25% nos Estados Unidos. É caracterizada por episódios recorrentes de inflamação intraocular, separados por períodos de remissão, nos quais não há sinais de inflamação intraocular ativa. Evidências recentes correlacionam-na com uma forte resposta autoimune, despoletada após infeção por Leptospira. Embora a terapêutica médica anti-inflamatória seja eficaz no controlo da

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Mussnich, Heloisa Guedes. "Sobrevida e fatores prognósticos em pacientes com adenocarcinoma primário de reto." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2000. http://hdl.handle.net/10183/11367.

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O câncer colorretal é a terceira neoplasia mais freqüente no mundo ocidental. No reto encontram-se 30 a 57% dos casos, sendo 80% destes passíveis de alcançar pelo exame digital do reto. Apesar de inúmeros avanços diagnósticos e terapêuticos, ainda são detectados tardiamente. A sobrevida em 5 anos mantém-se em torno de 50%, e os aspectos clínicopatológicos são os critérios prognósticos disponíveis. O presente estudo objetiva avaliar a sobrevida e os fatores clínico-patológicos relacionados aos tumores de reto em nosso meio. Os prontuários de 112 pacientes com adenocarcinoma primário e único de

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Viitanen, Matti. "Long-term effects of stroke." Doctoral thesis, Umeå universitet, Rehabiliteringsmedicin, 1987. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100559.

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Stroke, which has an increasing incidence with age, causes an irreversible brain damage which may lead to impairment, disability and decreased life satisfaction or death. Risk factors for death, recurrent stroke and myocardial infarction, were analyzed in 409 stroke patients treated at the Stroke Unit, Department of Medicine, Umeå University Hospital, between Jan. 1, 1978 and Dec. 31, 1982. The causes of death were related with the time of survival. In fully co-operable (n=62) 4-6 year stroke survivors, the occurrence of motor and perceptual impairments, of self-care (ADL) disability and of se

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Mohammadisohrabi, Ali. "Design and implementation of a Recurrent Neural Network for Remaining Useful Life prediction." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020.

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A key idea underlying many Predictive Maintenance solutions is Remaining Useful Life (RUL) of machine parts, and it simply involves a prediction on the time remaining before a machine part is likely to require repair or replacement. Nowadays, with respect to fact that the systems are getting more complex, the innovative Machine Learning and Deep Learning algorithms can be deployed to study the more sophisticated correlations in complex systems. The exponential increase in both data accumulation and processing power make the Deep Learning algorithms more desirable that before. In this paper a L

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Perrouin-Verbe, Marie-Aimée. "Valeur pronostique du remodelage de la signalisation calcique dans le cancer de la prostate." Thesis, Brest, 2017. http://www.theses.fr/2017BRES0159.

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Le cancer de prostate (CaP) est le plus fréquent chez l’homme de plus de 50 ans. La généralisation du PSA et du dépistage du CaP a permis son diagnostic à des formes localisées (80% des formes diagnostiquées), accessibles à un traitement curatif. De plus, un certain nombre de ces formes localisées sont indolentes, de très faible risque, éligibles à une surveillance active (SA).Cependant, 15 à 25% des patients vont présenter une récidive 10 ans après un traitement curatif, et environ 30% des patients inclus en SA seraient en fait sous-évalués (cancer significatif). Il est donc nécessaire d’iden

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Pedreira, Gonçalo Gomes Ferreira Marques. "Identificação e análise de variáveis com influência no intervalo livre de doença pós-cirúrgico de neoplasias malignas orais no cão : um estudo retrospetivo." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2019. http://hdl.handle.net/10400.5/19749.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>A cavidade oral é a quarta localização anatómica mais comum no cão para o desenvolvimento de cancro. As neoplasias malignas não odontogénicas caninas mais comuns são, por ordem decrescente de prevalência, o melanoma maligno, o carcinoma espinocelular, o fibrossarcoma e o osteossarcoma. A maioria são tumores com comportamento invasivo, podendo ocorrer metastização, sendo a excisão cirúrgica com amplas margens a abordagem terapêutica mais rápida, económica e eficaz. Massas com maior dimensão e com localização caudal apresentam pior pro

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Petitprez, Florent. "Integrated analysis and clinical impact of immune and stromal microenvironments in solid tumors Quantitative analyses of the tumor microenvironment composition and orientation in the era of precision medicine Transcriptomic analysis of the tumor microenvironment to guide prognosis and immunotherapies Tumor microenvironment quantification tool draws a comprehensive map of the tumor microenvironment of non-hematologic human cancers The mMCP-counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations using gene expression in murine samples Immune sub-classes in sarcoma predict survival and immunotherapy response Intra-tumoral tertiary lymphoid structures are associated with a low risk of hepatocellular carcinoma early recurrence Association of IL-36γ with tertiary lymphoid structures and inflammatory immune infiltrates in human colorectal cancer Immune-based identification of cancer patients at high risk of progression Tumor-infiltrating and peripheral blood T-cell immunophenotypes predict early relapse in localized clear cell renal cell carcinoma PD-L1 expression and CD8+ T-cell infiltrate are associated with clinical progression in patients with node-positive prostate cancer Intratumoral classical complement pathway activation promotes cancer progression". Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB104.

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Les tumeurs sont composées de cellules malignes et d'une grande variété de cellules non-tumorales, en particulier des cellules immunitaires qui forment le micro-environnement tumoral (MET). Il a été démontré que la composition du MET était associée au devenir clinique des patients, en termes de survie et de réponses thérapeutiques. Avec le développement récent des immunothérapies qui ciblent des éléments spécifiques du MET, l'immunité anti-tumorale a soulevé un intérêt majeur. Plusieurs méthodologies ont été mises au point afin d'étudier la composition du MET, avec une précision toujours plus

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Huang, Wei. "A Population-Based Perspective on Clinically Recognized Venous Thromboembolism: Contemporary Trends in Clinical Epidemiology and Risk Assessment of Recurrent Events: A Dissertation." eScholarship@UMMS, 2011. http://escholarship.umassmed.edu/gsbs_diss/730.

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Background: Venous thromboembolism (VTE), comprising the conditions of deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common acute cardiovascular event associated with increased long-term morbidity, functional disability, all-cause mortality, and high rates of recurrence. Major advances in identification, prophylaxis, and treatment over the past 3-decades have likely changed its clinical epidemiology. However, there are little published data describing contemporary, population-based, trends in VTE prevention and management. Objectives: To examine recent trends in the epidemiology

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Huang, Wei. "A Population-Based Perspective on Clinically Recognized Venous Thromboembolism: Contemporary Trends in Clinical Epidemiology and Risk Assessment of Recurrent Events: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/730.

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Background: Venous thromboembolism (VTE), comprising the conditions of deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common acute cardiovascular event associated with increased long-term morbidity, functional disability, all-cause mortality, and high rates of recurrence. Major advances in identification, prophylaxis, and treatment over the past 3-decades have likely changed its clinical epidemiology. However, there are little published data describing contemporary, population-based, trends in VTE prevention and management. Objectives: To examine recent trends in the epidemiology

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Almeida, Gisele Caravina de. "Análise das frequências dos subgrupos moleculares dos meduloblastomas e associações com possíveis fatores prognósticos." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-13012015-110401/.

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INTRODUÇÃO: Meduloblastoma é o tumor cerebral embrionário maligno mais comum da infância. O esquema de tratamento atual inclui ressecção cirúrgica, radioterapia e quimioterapia. Embora a taxa de sobrevida global tenha aumentado nos últimos anos, em decorrência do tratamento os sobreviventes frequentemente sofrem com sequelas de ordem neurológica, endocrinológica e social. O esquema de classificação de risco atual não considera a heterogeneidade existente entre os pacientes e entre os tumores. No entanto, estudos recentes reconheceram quatro subgrupos moleculares distintos de meduloblastomas (W

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Wassberger, Johanna, and Mahtab Yarahmadi. "Proliferation and expression of p53 in odontogenic tumours - An immunohistochemical analysis." Thesis, Malmö högskola, Odontologiska fakulteten (OD), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19756.

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Introduktion: Ameloblastom (AB), adenomatoid odontogen tumör (AOT), ameloblastiskt fibrom (AF) och odontogent fibrom (OF) är odontogena tumörer som innehåller epiteliala komponenter. Frekvensen av recidiv hos dessa varierar från låg förekomst till relativt hög förekomst. Syftet med denna studie är att undersöka om Ki-67, p53 och BRAF kan användas som prognostiska markörer i recidivmönstret hos dessa tumörer.Material och metod: Studien genomfördes genom immunohistokemi med monoklonala antikroppar av Ki-67, p53 och BRAF på respektive tumör. Tumörerna hämtades från avdelningen för Oral patologi p

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Krige, J. E. J. "Endoscopic injection sclerotherapy in the treatment of bleeding oesophageal varices in patients with portal hypertension due to alcohol-induced cirrhosis : an assessment of acute control of bleeding, prevention of recurrent bleeding and prognostic factors predicting early variceal rebleeding and death." Master's thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/22099.

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The ideal treatment of portal hypertension and bleeding varices should be universally effective, safe, easy to administer and inexpensive. Currently no such treatment exists and the surgeon or physician is obliged to select the most appropriate intervention from a menu of currently available therapeutic options, none of which is ideal or applicable to all patients. The rational treatment of oesophageal varices depends on a clear understanding of the risks of rebleeding and the response to each specific intervention. The selection of the correct and appropriate intervention is critical and requ

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Sammain, Simon Nadim. "Prognosefaktoren und Indikationsstellung bei der Behandlung kolorektaler Lebermetastasen." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-63899.

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Ziel der vorliegenden Arbeit ist die retrospektive Beurteilung der Sicherheit und Effektivität der Leberteilresektion bei der Behandlung von Lebermetastasen des kolorektalen Karzinoms sowie der Re-Resektion bei Patienten mit Rezidivlebermetastasen. Weiterhin soll das operative Vorgehen bei synchronen Lebermetastasen hinsichtlich simultaner Resektionsverfahren und zweizeitigen Vorgehens untersucht werden. Insgesamt wurden die Ergebnisse von 660 Patienten ausgewertet, die zwischen 1988 und 2004 mit 685 Leberteilresektionen behandelt wurden. Unter diesen waren 75 Patienten, die eine Re-Resektion

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