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Journal articles on the topic 'Prognosis e recurrence'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Sako, Keisuke, Kengo Furuichi, Yuta Yamamura, et al. "Association between the recurrence period of acute kidney injury and mortality: a single-centre retrospective observational study in Japan." BMJ Open 9, no. 6 (2019): e023259. http://dx.doi.org/10.1136/bmjopen-2018-023259.

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ObjectivesRecurrent acute kidney injury (AKI) is a recognised risk factor for mortality. However, it is unclear whether the period until AKI recurrence may have a major factor on patient outcome or not. To explore this issue, we (1) framed the hypothesis that early recurrence increases the risk of mortality and (2) evaluated the prognosis of recurrent AKI cases by setting 21 days as the cut-off period.MethodsAll studied cases were admitted and followed up at the Kanazawa University Hospital (Kanazawa, Japan) between 1 November 2006 and 31 October 2007. In total, 21 939 patients were retrospect

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Davydova, Irina, Apollon Karseladze, Viktor Kuznetsov, and Liudmila Meshcheriakova. "Surgical treatment of recurrent borderline serous ovarian tumor." Problems in oncology 67, no. 4 (2021): 538–46. http://dx.doi.org/10.37469/0507-3758-2021-67-4-538-546.

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Recurrences of serous borderline tumors (PCOS) are quite rare and, as a result, have not been sufficiently studied and presented in the literature. Despite the obvious relative «benignity» of borderline tumors, the course and prognosis of recurrent PCOS may be unfavorable. The article describes the reasons influencing the development of recurrence of PCOS, presents various options for recurrence of PCOS, methods of their treatment. This publication highlights the factors influencing the effectiveness of treatment, survival and prognosis of the disease. The article is illustrated with a rare cl

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3

Osako, T., R. Nishimura, Y. Okumura, R. Tashima, Y. Toyozumi, and N. Arima. "Survival after locoregional recurrence in patients after breast cancer surgery." Journal of Clinical Oncology 29, no. 27_suppl (2011): 141. http://dx.doi.org/10.1200/jco.2011.29.27_suppl.141.

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141 Background: The purpose of this study was to investigate factors for survival after locoregional recurrence in patients who underwent mastectomy or breast-conserving therapy (BCT) for primary breast cancer in our hospital. Methods: Out of 3,332 patients operated on from 1989 to 2008, 50 patients had chest wall recurrences after mastectomy (CWR), 40 patients had regional nodal recurrences (RNR), and 24 patients had ipsilateral breast tumor recurrences (IBTR) from 1997 to 2008. To investigate the prognostic factors for survival after locoregional recurrence, we conducted uni- and multivariat

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Gronchi, A., P. G. Casali, L. Mariani, et al. "Quality of Surgery and Outcome in Extra-Abdominal Aggressive Fibromatosis: A Series of Patients Surgically Treated at a Single Institution." Journal of Clinical Oncology 21, no. 7 (2003): 1390–97. http://dx.doi.org/10.1200/jco.2003.05.150.

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Purpose: To explore prognostic factors in surgically treated aggressive fibromatosis (extra-abdominal desmoid tumor). Patients and Methods: A total of 203 consecutive patients treated with surgery over a 35-year period at a single referral center were retrospectively reviewed. One hundred twenty-eight were first seen at our institution with primary disease, whereas 75 had a recurrent tumor. All patients underwent macroscopically complete resection. Margins were rated as negative in 146 (97 with primary tumors, 49 with recurrences) and positive in 57 (31 in primary, 26 in recurrences) patients.

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Ma, Hui, Zhongchen Li, Jia Yuan, et al. "Extrapolating Prognostic Factors of Primary Curative Resection to Postresection Recurrences Hepatocellular Carcinoma Treatable by Radiofrequency Ablation." Gastroenterology Research and Practice 2021 (January 2, 2021): 1–7. http://dx.doi.org/10.1155/2021/8878417.

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Objective. Recurrence after curative resection for hepatocellular carcinoma (HCC) is a major cause of death from this disease. Factors of primary curative resection are available and potential in the prognosis of follow-up treatment. Our aim was to assess the prognostic significance of primary curative resection factors in recurrent HCC patients undergoing radiofrequency ablation therapy (RFA). Methods. In this retrospective study, we assessed 235 patients who underwent limited RFA of HCC recurrences ( tumors ≤ 5 cm ; nodules ≤ 3 ) after primary curative resection. Factors of primary curative

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Nishiyama, Mitsuo, Shigeru Takeda, Shinsuke Kanekiyo, et al. "PS02.214: ANALYSIS OF PROGNOSTIC FACTORS IN RECURRENCE CASES AFTER SURGERY FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA." Diseases of the Esophagus 31, Supplement_1 (2018): 182–83. http://dx.doi.org/10.1093/dote/doy089.ps02.214.

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Abstract Background Esophageal cancer is one of the most malignant gastrointestinal cancers and prognosis in recurrent cases remains extremely poor. However some studies show a relatively favorable prognosis among patients with solitary recurrence site who undergo locoregional therapy. It is important to clarify prognostic factors in postrecurrence cases. Methods This study included 156 patients who underwent curative resection for esophageal squamous cell carcinoma from January 2005 to December 2014. In this retrospective study we analysed relationship between clinicopathologic factors and pr

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Li, Guangqi, Yuanjun Jiang, Xintong Lyu, et al. "Deconvolution and network analysis of IDH-mutant lower grade glioma predict recurrence and indicate therapeutic targets." Epigenomics 11, no. 11 (2019): 1323–33. http://dx.doi.org/10.2217/epi-2019-0137.

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Aim: IDH-mutant lower grade glioma (LGG) has been proven to have a good prognosis. However, its high recurrence rate has become a major therapeutic difficulty. Materials & methods: We combined epigenomic deconvolution and a network analysis on The Cancer Genome Atlas IDH-mutant LGG data. Results: Cell type compositions between recurrent and primary gliomas are significantly different, and the key cell type that determines the prognosis and recurrence risk was identified. A scoring model consisting of four gene expression levels predicts the recurrence risk (area under the receiver operatin

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Chen, Yue, Rui Zhang, Xinxin Dong, and Fang Liu. "Evaluation of prognosis of rectal cancer patients with neoadjuvant chemoradiotherapy by clinical TNM stage: Is it suitable?" Journal of Clinical Oncology 38, no. 15_suppl (2020): e16029-e16029. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e16029.

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e16029 Background: In the Union for International Cancer Control /American Joint Committee on Cancer TNM classification system, the prognosis of rectal cancer patients with adjuvant treatment are based on pre-radiotherapy clinical TNM stage. However, the value of this classification system is still debated. Here, we find that neoadjuvant pathologic TNM stage may be better than clinical TNM stage in patients with rectal cancer. Furthermore, we propose a novel risk stratification which may be more accurate in the assessment of prognosis of these patients. Methods: Between 2010 and 2015, 316 pati

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Jud, Sebastian M., Reinhard Hatko, Julius Emons, et al. "Discordance between Primary Breast Cancer and Ipsilateral Breast Cancer Tumor Recurrence as a Function of Distance." Journal of Clinical Medicine 9, no. 12 (2020): 4033. http://dx.doi.org/10.3390/jcm9124033.

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Background: Risk factors for ipsilateral breast cancer tumor recurrence (IBTR) are well established and include grading, nodal status, and receptor status. Little is known about the influence of the local distance between the primary tumor and recurrences on changes in tumor characteristics and prognosis. Methods: In a retrospective setting, we analyzed primary breast cancers and their recurrences. Localizations of primary and recurrent breast cancer were recorded to calculate the relative distance in pixels. Analysis was performed regarding tumor characteristics, relative distance between bot

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Ninomiya, Itasu, Koichi Okamoto, Katsunobu Oyama, Jun Kinoshita, Sachio Fushida, and Tetsuo Ohta. "FA06.04: SURVIVAL BENEFIT OF MULTIMODAL LOCAL THERAPY FOR REPEAT RECURRENCE OF THORACIC ESOPHAGEAL SQUAMOUS CELL CARCINOMA AFTER THORACOSCOPIC ESOPHAGECTOMY." Diseases of the Esophagus 31, Supplement_1 (2018): 12. http://dx.doi.org/10.1093/dote/doy089.fa06.04.

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Abstract Background This study was performed to clarify the optimal therapeutic strategy for recurrent disease after thoracoscopic esophagectomy (TE). We especially focused on the prognostic impact of multimodal local therapy for localized recurrence. Methods We investigated the prognosis of 49 patients who developed recurrence among 140 patients who underwent TE at Kanazawa University Hospital. The prognostic factors after recurrence were examined by univariate and multivariate analysis. Results The patterns of initial recurrence included hematological recurrence in 24 patients (17.1%), lymph

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Tryggvadottir, Helga, Maria Ygland Rödström, Andrea Markkula, et al. "The impact of body size changes on recurrence risk depends on age and estrogen receptor status in primary breast cancer." Cancer Causes & Control 30, no. 11 (2019): 1157–70. http://dx.doi.org/10.1007/s10552-019-01227-6.

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Abstract Purpose To investigate the prognostic impact of body size changes during the first postoperative year in breast cancer. Methods A cohort of 1,317 primary breast cancer patients included in Sweden (2002–2014) underwent body size measurements at the preoperative and 1-year visits (n = 1,178). Landmark survival analyses were used to investigate how postoperative weight gain or loss (> 5%) or change in waist–hip ratio (WHR) categories (≤ 0.85 or > 0.85) impact prognosis. Results Median age at inclusion was 61 years and body mass index 25.1 kg/m2. After a median follow-up of 5.0 year

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Fukahori, Masaru, Yoshiki Naito, Hiroto Ishikawa, et al. "Clinico-pathological analyses of the relationship between SMAD4, TP53, CDKN2A mutations and recurrence and prognosis in patients with pancreatic cancer: A single institutional study." Journal of Clinical Oncology 36, no. 4_suppl (2018): 319. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.319.

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319 Background: Gene mutations of SMAD4, TP53 and CDKN2A( p16) have been reported to be associated with poor prognosis and metastatic burden in advanced pancreatic cancer (PC). On the other hand, the association between these gene mutations and recurrence in PC is still unclear. The present study aimed to whether the 3 gene mutations were related to the recurrence and the prognosis in PC patients. Methods: Formalin-fixed paraffin-embedded tumor samples were gathered from patients with PC who underwent curative resection between January 2014 and December 2015. We retrospectively evaluated a rel

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Purim, Ofer, Alina Weismann-Brenner, Michal Kushnir, et al. "Tumor microRNA-29a expression and the risk of recurrence in stage II colon cancer." Journal of Clinical Oncology 30, no. 15_suppl (2012): e14067-e14067. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e14067.

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e14067 Background: To compare the microRNA (miRNA) profiles in the primary tumor of patients with recurrent and non-recurrent colon cancer. Methods: The study population included 110 patients, 51 (46%) with stage I and 59 (54%) with stage II disease, who underwent curative colectomies between 1995-2005 without adjuvant therapy and for whom reliable miR expression data was available. RNA was extracted from formalin-fixed paraffin-embedded tumor samples. Initial profiling, using microarrays, was done in order to identify potential biomarkers of recurrence. The miRNA expression was later verified

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Biyani, Garima, Syed Md Azad, Souvik Guha, Rohit Kapoor, and Hriday De. "Recurrent immune thrombocytopenic purpura with excellent prognosis." International Journal of Research in Medical Sciences 5, no. 4 (2017): 1697. http://dx.doi.org/10.18203/2320-6012.ijrms20171290.

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Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by increase in destruction of circulatory platelets and is the most common cause of acquired thrombocytopenia in childhood. ITP can be classified based on duration of thrombocytopenia as acute and chronic form. Recurrent ITP is defined as recurrence of symptoms, after at least three months of remission sustained without any treatment. It is a rare entity and seen in just 5% of all ITP cases. Further, its treatment is often cumbersome and warrants use of non-conventional drugs and splenectomy. Reported here is a case

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Hirokawa, Fumitoshi, Michihiro Hayashi, Mitsuhiro Asakuma, et al. "Early Recurrence After Initial Hepatectomy for Colorectal Liver Metastases." International Surgery 104, no. 7-8 (2019): 375–82. http://dx.doi.org/10.9738/intsurg-d-17-00018.1.

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Objective This study investigated the frequency of early recurrence in patients who had undergone hepatectomy for colorectal cancer liver metastasis (CRLM) and assessed the indications for adjuvant chemotherapy in these patients. Methods This retrospective analysis included 133 consecutive patients who underwent initial hepatectomy for CRLM between April 2000 and May 2010 and have been followed more than 5 years. Results Of the 133 patients, 83 (62%) experienced tumor recurrence, with 14 of the 83 recurrences within 6 months after initial hepatectomy. Overall survival was significantly poorer

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Favorito, Luciano A. "Prostate Cancer: Prognosis and Recurrence." International braz j urol 39, no. 3 (2013): 302–4. http://dx.doi.org/10.1590/s1677-5538.ibju.2013.03.01.

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O'Connell, Michael J., Megan E. Campbell, Richard M. Goldberg, et al. "Survival Following Recurrence in Stage II and III Colon Cancer: Findings From the ACCENT Data Set." Journal of Clinical Oncology 26, no. 14 (2008): 2336–41. http://dx.doi.org/10.1200/jco.2007.15.8261.

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Purpose This study was undertaken to examine five possible prognostic factors in patients with recurrent stage II and III colon cancer: time from randomization on an adjuvant therapy clinical trial to tumor recurrence (< 1 year, 1 to 2 years, 2 to 3 years, 3 to 4 years, > 4 years), initial stage (II v III), initial adjuvant treatment (fluorouracil [FU]-based v surgery alone), the era in which the patient entered an adjuvant therapy clinical trial (1978 to 1985, 1986 to 1992, 1993 to 1999), and patient age at recurrence. Methods The Adjuvant Colon Cancer End Points (ACCENT) data set was a

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Bricou, Alexandre, Sofiane Bendifallah, Mathilde Daix-Moreux, et al. "A Proposal for a Classification for Recurrent Endometrial Cancer: Analysis of a French Multicenter Database From the FRANCOGYN Study Group." International Journal of Gynecologic Cancer 28, no. 7 (2018): 1278–84. http://dx.doi.org/10.1097/igc.0000000000001296.

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ObjectiveEndometrial cancer (EC) recurrences are relatively common with no standardized way of describing them. We propose a new classification for them called locoregional, nodal, metastasis, carcinomatosis recurrences (rLMNC).Patients and MethodsThe data of 1230 women with EC who were initially treated by primary surgery were included in this French multicenter retrospective study. Recurrences were classified based on dissemination pathways: (1) locoregional recurrence (rL); (2) nodal recurrence (rN) for lymphatic pathway; (3) distant organ recurrence (rM) for hematogenous pathway; and (4) c

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Shinohara, Nobuo, Takashige Abe, Satoru Maruyama, Ataru Sazawa, and Katsuya Nonomura. "Prognosis of patients with renal cell carcinoma with disease recurrence following nephrectomy for localized disease." Journal of Clinical Oncology 30, no. 5_suppl (2012): 400. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.400.

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400 Background: We investigated the prognosis of Japanese patients with recurrent renal cell carcinoma (RCC) following nephrectomy, and analyzed the prognostic impact of metastasectomy and Memorial Sloan-Kettering Cancer Center (MSKCC) risk classification in these patients. Methods: Between 1995 and 2005, 214 patients with recurrent RCC were the subjects of this retrospective analysis. At recurrence, MSKCC risk classification was used to classify patients as being at favorable, intermediate, and poor risk. The endpoint of the present study was overall survival (OS) from time of recurrence. Rel

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Cheng, Xi, Rongyu Zang, Xiaohua Wu, Ziting Li, Shumo Cai, and Zhiyi Zhang. "Recurrence Patterns and Prognostic Factors in Chinese Patients With Squamous Cell Carcinoma of the Vulva Treated With Primary Surgery." International Journal of Gynecologic Cancer 19, no. 1 (2009): 158–62. http://dx.doi.org/10.1111/igc.0b013e3181996a78.

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The purpose of this study was to identify the prognostic factors for disease-free survival (DFS) and recurrence patterns in Chinese women with squamous cell carcinoma of the vulva treated with primary surgery. From 1980 through 2002, 100 patients with invasive squamous cell carcinoma of the vulva treated with primary surgery were included in this retrospective study. Survival analyses included the Kaplan-Meier method, log-rank test, and Cox proportional hazards model. The 5- and 10-year DFS rates were 66.5% and 45.2%, respectively. Among all the tumor-related variables age, International Feder

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van den Tillaart, Sabrina A. H. M., Annelies Schoneveld, Inge T. Peters, et al. "Abdominal Scar Recurrences of Cervical Cancer: Incidence and Characteristics: A Case-Control Study." International Journal of Gynecologic Cancer 20, no. 6 (2010): 1031–40. http://dx.doi.org/10.1111/igc.0b013e3181db5153.

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Background:Tumor recurrence in the surgical scar after radical hysterectomy for cervical cancer has been reported, but the incidence is unknown. Facts about patient and tumor characteristics and follow-up are lacking. The objective of this study was to analyze the incidence and characteristics of cervical cancer scar recurrences.Methods:All patients who were surgically treated for cervical cancer in our center between 1984 and 2007 were reviewed for scar recurrences. For each case, 5 random controls were selected. Clinical characteristics were compared between the cases and controls.Results:El

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Guo, Michael, Fahad Alasousi, Christopher Okpaleke, Al-Rahim Habib, and Amin Javer. "Prognosis of Chronic Rhinosinusitis With Nasal Polyps Using Preoperative Eosinophil/Basophil Levels and Treatment Compliance." American Journal of Rhinology & Allergy 32, no. 5 (2018): 440–46. http://dx.doi.org/10.1177/1945892418793523.

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Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have a high risk of disease recurrence and revision surgery. The ability to predict a polyp recurrence in this patient population is critical in order to provide adequately tailored postoperative management. Objective We aim to explore the role of appropriate postoperative care in the prognosis of CRSwNP patients in relation to preoperative eosinophil and basophils levels. Methods This was a retrospective case series; data were collected for 102 CRSwNP patients over a period of 15 months after surgery. Baseline eosinoph

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Lee, Chena, Yoon Joo Choi, Kug Jin Jeon, et al. "Prognostic Implications of Combined Imaging and Histologic Criteria in Squamous Cell Carcinoma with Mandibular Invasion." Journal of Clinical Medicine 9, no. 5 (2020): 1335. http://dx.doi.org/10.3390/jcm9051335.

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Prognosis prediction of squamous cell carcinoma (SCC) with mandibular invasion is controversial, and a more sophisticated staging system to aid prognosis could be developed with imaging characteristics of bone invasion. Imaging-feature analysis provides practical, stratified results for survival prognosis in oral SCC (OSCC) of the mandible, and imaging advances enable more detailed tumor visualization. We retrospectively evaluated significant bone-invasion features associated with poor outcomes in mandibular OSCC to assess the predictive value of staging criteria that combined imaging features

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Abner, A. L., A. Recht, T. Eberlein, et al. "Prognosis following salvage mastectomy for recurrence in the breast after conservative surgery and radiation therapy for early-stage breast cancer." Journal of Clinical Oncology 11, no. 1 (1993): 44–48. http://dx.doi.org/10.1200/jco.1993.11.1.44.

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PURPOSE The prognosis and factors that influence prognosis following salvage mastectomy in patients with recurrence in the treated breast after conservative surgery (CS) and radiation therapy (RT) were investigated. MATERIALS AND METHODS A total of 1,593 patients with stage I or II invasive breast cancer were treated following gross total excision of the tumor at the Joint Center for Radiation Therapy (JCRT) between 1968 and 1985. One hundred sixty-six of the 1,593 (10%) had subsequent recurrence in the breast. Of these, 123 had salvage mastectomy and constitute the study population. The recur

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Ogata, Takashi, Yota Shimoda, Shinsuke Nagasawa, et al. "Evaluation of prognostic factors after esophagectomy in which preoperative chemotherapy was successful." Journal of Clinical Oncology 37, no. 15_suppl (2019): e15568-e15568. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e15568.

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e15568 Background: Current standard treatment for Stage IB/II/III Japanese squamous cell carcinoma of the esophagus is esophagectomy after two courses preoperative chemotherapy with 5-FU/CDDP. Prognosis of cases in which preoperative chemotherapy was successful is usually good, but some cases were recurrence. On the other hand, some reports showed that the negative survival impact of infectious complications after esophagectomy is canceled out by succeeding preoperative chemotherapy. So we evaluate of prognostic factors after esophagectomy in which preoperative chemotherapy was successful. Met

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Kameda-Smith, Michelle M., Alick Wang, Noora Abdulhadi, et al. "Salvage Therapy for Childhood Medulloblastoma: A Single Center Experience." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 46, no. 04 (2019): 403–14. http://dx.doi.org/10.1017/cjn.2019.39.

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ABSTRACT:Introduction: Children diagnosed with medulloblastoma (MB) who are refractory to upfront therapy or experience recurrence have very poor prognoses. Although phase I and phase II trials exist, these treatments bear significant treatment-related morbidity and mortality. Methods: A retrospective review of children diagnosed with a recurrence of MB from 2002 to 2015 at McMaster University was undertaken. Results: Recurrent disease in 10 patients involved leptomeningeal dissemination, with 3 experiencing local recurrence. In three recurrent patients the disease significantly progressed, an

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Osako, T., R. Nishimura, Y. Okumura, and M. Hayashi. "Current status of treatment of local recurrence and distant metastasis of triple negative breast cancer in Japanese population." Journal of Clinical Oncology 27, no. 15_suppl (2009): e11548-e11548. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e11548.

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e11548 Background: Triple-negative breast cancers have an aggressive clinical history such as high incidence of visceral metastases, high rate of cerebral metastases, high rate of local recurrence, and early age of onset. However, there are limited long-term clinical data evaluating outcomes of locoregional and systemic therapy. The purpose of this study was to evaluate the clinical outcome of current therapy with TNBC retrospectively. Methods: From the medical records of our hospital, we retrospectively reviewed breast cancer patients whose three markers were available and describe the relati

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Schmoor, Claudia, Willi Sauerbrei, Gunter Bastert, and Martin Schumacher. "Role of Isolated Locoregional Recurrence of Breast Cancer: Results of Four Prospective Studies." Journal of Clinical Oncology 18, no. 8 (2000): 1696–708. http://dx.doi.org/10.1200/jco.2000.18.8.1696.

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PURPOSE: We evaluated the effect on future prognosis of an isolated locoregional recurrence (ILRR) after the primary diagnosis of breast cancer. Using data from four prospective studies of the German Breast Cancer Study Group, we investigated factors influencing prognosis after ILRR and defined a simple classification of patients into groups with different prognoses. PATIENTS AND METHODS: From 1983 to 1989, 2,746 patients were recruited into four studies comparing different treatments in primary breast cancer. After a median follow-up time of 8 years, 337 patients developed an ILRR as the firs

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Fritch, Ann. "Stroke Recurrence; Predictors, Severity, and Prognosis." Neurology Report 22, no. 1 (1998): 32–33. http://dx.doi.org/10.1097/01253086-199822010-00013.

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Kwon, Se Yun, Jun Nyung Lee, Bum Soo Kim, et al. "Impact of Microvascular Invasion and Tumor Necrosis on the Prognosis of Korean Patients with pT1b Renal Cell Carcinoma." Urologia Internationalis 95, no. 1 (2014): 65–71. http://dx.doi.org/10.1159/000366138.

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Objectives: To evaluate prognostic factors in pT1b renal cell carcinoma (RCC) patients for which no specific studies have been conducted on. Methods: The data of 270 patients diagnosed with pT1bN0M0 RCC at 2 institutions between January 1998 and June 2010 were retrospectively analyzed. Univariate and multivariate analyses using Cox proportional hazard models were used to identify pathologic and clinical factors that influenced prognosis. Five-year recurrence-free survival and cancer-specific survival were analyzed using the Kaplan-Meier method. Results: The median follow-up period was 55.5 mon

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Kameda-Smith, MM, A. Wang, A. Adile, et al. "P.044 Salvage therapy in recurrent pediatric medulloblastoma: A single centre experience." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 45, s2 (2018): S27. http://dx.doi.org/10.1017/cjn.2018.146.

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Background: Children diagnosed with medulloblastoma (MB) that are refractory to upfront therapy or experience recurrence have very poor prognoses. Reports of phase I and II studies for these children exist, but bear significant treatment related morbidity and mortality. Methods: A retrospective review of children diagnosed with a pediatric MB from 2002-2015 from the McMaster Pediatric Brain Tumour Study Group (PBTSG) captured a number of pediatric recurrent MB. Results: Over the 13-year period, 31 children with a histological diagnosis of MB were treated. At two years, 21 (67.7%) of 31 patient

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Nakamura, Yuki, Koichi Toda, Shigeru Miyagawa, et al. "Surgical Resection and Pazopanib Treatment for Recurrent Cardiac Angiosarcoma." Clinical Pathology 12 (January 2019): 2632010X1983126. http://dx.doi.org/10.1177/2632010x19831261.

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Cardiac sarcoma treatment is challenging for surgeons because of frequent tumor recurrence and poor prognosis. In addition, optimal management of recurrences is not well established. The multi-targeted tyrosine kinase inhibitor, pazopanib, was recently approved for soft-tissue sarcoma. Herein, we present a case involving recurrent cardiac angiosarcoma where the patient survived for 2 years with complete remission of disease after repeated surgical resection and treatment with oral pazopanib. Based on our experience, aggressive surgical resection combined with pazopanib may be a valid treatment

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Stenmark Tullberg, Axel, Emma Nimeus-Malmström, Fredrika Killander, et al. "Tumor-infiltrating lymphocytes in ipsilateral breast tumor recurrences predict prognosis." Journal of Clinical Oncology 38, no. 15_suppl (2020): 546. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.546.

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546 Background: The antitumoral immune response is dynamic and changes with tumor progression. Previous studies show that immunohistochemical (IHC) assessment of TILs in local recurrences can predict prognosis. It is not clear how adjuvant radiotherapy (RT) can alter the local immune response or if gene expression analyses of TILs in recurrences can provide prognostic information. Methods: Matched biopsies from primary tumors and ipsilateral breast tumor recurrences (IBTRs) from the randomized SweBCG91RT trial were assessed for TILs. Analyses were performed using gene expression (86 matched pa

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Klapper, Luise, Julika Ribbat-Idel, Patrick Kuppler, et al. "NR2F6 as a Prognostic Biomarker in HNSCC." International Journal of Molecular Sciences 21, no. 15 (2020): 5527. http://dx.doi.org/10.3390/ijms21155527.

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Head and neck squamous cell carcinoma (HNSCC)is the 6th most common cancer in humans worldwide and is associated with a poor prognosis for patients. NR2F6 has been identified as an immune checkpoint molecule in tumor-infiltrating T lymphocytes and is associated with a poor prognostic outcome in various cancers. The prognostic value of NR2F6 in HNSCC has not been described yet. We used a large, representative and clinically well-characterized cohort of 383 HNSCC patients, of which 22.4% developed a local recurrence. The NR2F6 expression was analyzed by using immunohistochemistry and was afterwa

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van den Brink, Mandy, Anne M. Stiggelbout, Wilbert B. van den Hout, et al. "Clinical Nature and Prognosis of Locally Recurrent Rectal Cancer After Total Mesorectal Excision With or Without Preoperative Radiotherapy." Journal of Clinical Oncology 22, no. 19 (2004): 3958–64. http://dx.doi.org/10.1200/jco.2004.01.023.

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Purpose To document the clinical nature and prognosis of locally recurrent rectal cancer after total mesorectal excision (TME) with or without 5 × 5 Gy preoperative radiotherapy (PRT) and to identify patient-, disease-, and treatment-related factors associated with differences in prognosis after local recurrence. Patients and Methods For 96 Dutch patients with a local recurrence who participated in a multicenter randomized clinical trial, data on treatments and follow-up were gathered from surgeons and radiation and medical oncologists. Twenty-three patients (24%) had previously been treated w

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Iwase, Haruko, Seigi Furukawa, Takeshi Hirasawa, et al. "The Clinical Features of Recurrent Endometrial Cancer in Japan: Chemotherapy Instead of Radiotherapy as Postoperative Adjuvant Treatment." International Journal of Gynecologic Cancer 28, no. 8 (2018): 1616–23. http://dx.doi.org/10.1097/igc.0000000000001346.

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ObjectiveChemotherapy is a standard adjuvant treatment after primary surgery for endometrial cancer in Japan. We aimed to characterize the clinical features of recurrent endometrial cancer (REC) patients in Japan.Materials and MethodsWe retrospectively reviewed the medical records of 112 REC patients who were primarily treated at 1 of 3 university hospitals in Japan from 2005 to 2012. We analyzed overall survival since the first recurrence (R-OS) in accordance with several factors.ResultsMedian patient age was 64 years. The median follow-up period was 48 months. The distributions of cancer sta

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Xu, Shaohua, Jie Zhou, Kai Liu, Zhoumiao Chen, and Zhengfu He. "A Recurrence-Specific Gene-Based Prognosis Prediction Model for Lung Adenocarcinoma through Machine Learning Algorithm." BioMed Research International 2020 (November 7, 2020): 1–10. http://dx.doi.org/10.1155/2020/9124792.

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Background. After curative surgical resection, about 30-75% lung adenocarcinoma (LUAD) patients suffer from recurrence with dismal survival outcomes. Identification of patients with high risk of recurrence to impose intense therapy is urgently needed. Materials and Methods. Gene expression data of LUAD were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Differentially expressed genes (DEGs) were calculated by comparing the recurrent and primary tissues. Prognostic genes associated with the recurrence-free survival (RFS) of LUAD patients were identifie

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Li, Man, Baogang Zhang, Zhiguang Zhang, et al. "Stem Cell-Like Circulating Tumor Cells Indicate Poor Prognosis in Gastric Cancer." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/981261.

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Circulating tumor cells (CTCs), which have stem cell-like characteristics, might play a crucial role in cancer metastasis. CD44 has been identified as gastric cancer (GC) stem cell (CSC) marker. Here, the prognostic significance of CD44-positive CTCs in GC patients was investigated. CTCs were detected in 27 of 45 GC patients. The presence of CTCs was significantly associated with lymph node metastasis, distant metastasis, and recurrence (P=0.007,P=0.035, andP=0.035, resp.). Nineteen of the 27 CTC-positive patients had CD44-positive CTCs. These patients were more likely to develop metastasis an

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Nan Hu. "2435." Journal of Clinical and Translational Science 1, S1 (2017): 27–28. http://dx.doi.org/10.1017/cts.2017.106.

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OBJECTIVES/SPECIFIC AIMS: The goal of the study is to evaluate the prognostic importance and accuracies of a biomarker, human epidermal receptor 2 (Her2), for breast cancer recurrence in a cohort study, namely Lifetime after Cancer Epidemiology (LACE). We specifically interested in the role that Her2 plays in prognosis of breast tumor recurrence for women after a previously diagnosed and treated breast cancer. METHODS/STUDY POPULATION: The study cohort includes 2267 women enrolled in LACE who had previously diagnosed breast cancer. Patients were enrolled from each of the 2 LACE registries in C

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Park, Junseok, Joon Seong Lee, Jin-Oh Kim, et al. "Prognosis of gastric dysplasia after complete resection with endoscopic procedures." Journal of Clinical Oncology 37, no. 4_suppl (2019): 27. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.27.

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27 Background: Gastric adenomas are considered premalignant, and some can be interpreted as cancer according to different pathologic guidelines. The dysplastic lesions share histologic characteristics including mucin phenotype that are related prognosis. The prognosis of the lesions has been studied but tends to be researched separately. Moreover, the proposed prognostic factors are mostly derived from the study of surgical specimens, and most of them did not consider the anatomical changes after surgery. Previously researched prognostic factors of gastric dysplasia were evaluated on the recur

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Lewis, Mark, Harry H. Yoon, Qian Shi, Robert B. Diasio, and Frank A. Sinicrope. "Post-recurrence survival in patients with previously resected esophageal adenocarcinoma (EAC)." Journal of Clinical Oncology 30, no. 15_suppl (2012): 4075. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.4075.

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4075 Background: EAC recurrence after surgery with curative intent is believed to carry a uniformly dismal prognosis that may discourage further therapy. To date, the post-recurrence survival of patients has not been examined in EAC. Our aim was to examine site of recurrence in relation to outcome in EAC patients after surgery. Methods: Among EAC patients (N = 796) rendered margin-free at surgery performed at Mayo Clinic, most were T3-4 and lymph node (LN)-positive; none received neoadjuvant therapy. The patient subset who had documented disease recurrence (N = 401) formed the current study po

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Mori, Kanji, Tetsuya Kumagai, Maki Kobayashi, et al. "RTHP-21. TREATMENTS FOR RECURRENT MALIGNANT GLIOMAS AND THEIR PROGNOSIS." Neuro-Oncology 21, Supplement_6 (2019): vi214. http://dx.doi.org/10.1093/neuonc/noz175.892.

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Abstract For improvement of glioma therapy, advances in treatment after recurrence are essential, but no standard second line therapy has been estimated. Lately, bevacizumab (Bev) and BCNU wafer became available in Japan, we have more therapeutic choices. Since we took part in Kansai molecular diagnosis network for CNS tumors in 2013, we have referred molecular information. We retrospectively examined and report our experiment about recurrent malignant gliomas in Kansai Rossi Hospital. Twenty-two histopathologically proved grade 3 and grade 4 patients who were diagnosed as recurrence between J

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Xing, Mingzhao, William H. Westra, Ralph P. Tufano, et al. "BRAF Mutation Predicts a Poorer Clinical Prognosis for Papillary Thyroid Cancer." Journal of Clinical Endocrinology & Metabolism 90, no. 12 (2005): 6373–79. http://dx.doi.org/10.1210/jc.2005-0987.

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Context: Use of BRAF mutation in papillary thyroid cancer (PTC) has the potential to improve risk stratification of this cancer. Objective: The objective of the study was to investigate the prognostic value of BRAF mutation in patients with PTC. Design, Setting, and Subjects: In a multicenter study of 219 PTC patients, data on their clinicopathological characteristics and clinical courses between 1990 and 2004 were retrospectively collected, and their tumor BRAF mutation status was determined. Associations of BRAF mutation with initial tumor characteristics and subsequent recurrence were analy

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Schott, Inna, Sven-Thorsten Liffers, Farhad Farzaliyev, et al. "Localized Angiosarcoma, Not One Disease: A Retrospective Single-Center Study on Prognosis Depending on the Primary Site and Etiology." Sarcoma 2021 (September 10, 2021): 1–10. http://dx.doi.org/10.1155/2021/9960085.

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Background. Angiosarcomas are rare and heterogeneous tumors with poor prognosis. The clinical subtypes are classified depending on the primary site and etiology. Methods. We conducted a retrospective, monocentric study of 136 patients with localized AS between May 1985 and November 2018. Overall survival (OS), local recurrence-free survival (LRFS), and metastasis-free survival (MFS) were estimated using the Kaplan–Meier method. To identify prognostic factors, univariate and multivariate analyses were performed based on Cox regressions. Results. The median age was 67 years (19–72.8 years). Prim

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O'Leary, Denis A., and Alan S. Lee. "Seven Year Prognosis in Depression." British Journal of Psychiatry 169, no. 4 (1996): 423–29. http://dx.doi.org/10.1192/bjp.169.4.423.

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BackgroundThe longer term prognosis of depressed patients treated with ECT is relatively unknown. We describe seven-year mortality and readmission risks for the Nottingham ECT series.MethodCases were defined and subtyped using the Present State Examination (PSE). Follow-up was naturalistic. Death and readmission were ascertained using the Nottingham case register.ResultsThe risk of death was doubled (SMR=1.99, 95% CI = 1.34–2.84, P < 0.001). The seven-year cumulative probability of remaining without readmission was 0.27 (95% CI 0.19–0.35), being 0.79 (0.71–0.87) at 16 weeks (relapse) and 0.

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Dinh, Trish, Natalie Andrews Wright, Hari Iyer, and Johanne I. Weberpals. "Recurrent vulvar squamous cell carcinoma: An analysis of clinical outcomes by treatment modality including surgery, chemotherapy, and radiation." Journal of Clinical Oncology 38, no. 15_suppl (2020): e18033-e18033. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e18033.

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e18033 Background: Recurrent VSCC carries a poor prognosis, but real-world data on outcomes with standard treatment options are lacking. Specifically, progression free survival (PFS) in recurrent VSCC is ill-defined which is problematic for the design of clinical trials with novel therapies. We aim to address the paucity of outcome data in recurrent VSCC and to compare PFS and overall survival (OS) in patients (pts) undergoing surgery, chemotherapy, radiotherapy or a combination of these treatments. Methods: A retrospective chart review identified 246 pts from 2000-2018 diagnosed with VSCC tre

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Ikebe, Masahiko, Nobuhide Kubo, Seiichi Fukuyama, and Tokujiro Yano. "Successful curative surgery for postoperative oesophageal recurrence of oesophagogastric junction cancer." BMJ Case Reports 13, no. 7 (2020): e234829. http://dx.doi.org/10.1136/bcr-2020-234829.

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A man in his 70s had undergone total gastrectomy for oesophagogastric junction cancer. Three years and 11 months later, he began to vomit after meals and was diagnosed with mediastinal recurrence of oesophagogastric junction cancer. A CT scan showed that the tumour was suspected of infiltrating the aorta and lung. He received two cycles of chemotherapy with S-1 plus cisplatin, resulting in tumour reduction. The patient underwent resection of the lower oesophagus, including the tumour, the left lower lobe of the lung and the pericardium through a left thoracoabdominal incision. This is the firs

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Sahakyan, Mushegh A., Airazat M. Kazaryan, Ewa Pomianowska, et al. "Laparoscopic Resection of Recurrence from Hepatocellular Carcinoma after Liver Transplantation: Case Reports and Review of the Literature." Case Reports in Oncological Medicine 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/8946471.

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Background. Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) indicates a poor prognosis. Surgery is considered the only curative option for selected patients with HCC recurrence following LT. Traditionally, the preference is given to the open approach.Methods. In this report, we present two cases of laparoscopic resections (LR) for recurrent HCC after LT, performed at Oslo University Hospital, Rikshospitalet.Results. Both procedures were executed without intraoperative and postoperative adverse events. Whereas one of the patients had a recurrence one year after LR,

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Preti, Mario, Fulvio Borella, Niccolò Gallio, et al. "Superficially Invasive Vulvar Squamous Cell Carcinoma: A 37-Year-Long Experience of a Tertiary Referral Center." Cancers 13, no. 15 (2021): 3859. http://dx.doi.org/10.3390/cancers13153859.

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Superficially, invasive vulvar squamous cell carcinoma (SISCCA) (FIGO stage IA) is a rare subset of vulvar cancer defined as a single lesion measuring ≤2 cm with a depth of invasion of ≤1.0 mm. This is a retrospective study performed on 48 patients with SISCCA, surgically treated between 1981 and 2018 at the S. Anna Hospital, University of Turin, to evaluate pathological characteristics and prognosis of these tumors. Ten patients (21%) recurred: seven (14%) as SISCCA and three (7%) as deeply invasive carcinoma. One case with perineural invasion and groin node metastasis at recurrence. No patie

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Priest, John R., D. Ashley Hill, Gretchen M. Williams, et al. "Type I Pleuropulmonary Blastoma: A Report From the International Pleuropulmonary Blastoma Registry." Journal of Clinical Oncology 24, no. 27 (2006): 4492–98. http://dx.doi.org/10.1200/jco.2005.05.3595.

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Purpose Type I pleuropulmonary blastoma (PPB) is a rare, cystic lung neoplasm in infants characterized by subtle malignant changes and a good prognosis. Recurrences after type I PPB are usually advanced type II or type III neoplasms with a poor prognosis. This article describes the first collection of type I PPB cases, analyzes outcome based on treatments of surgery or surgery plus chemotherapy, and presents type I PPB management recommendations. Patients and Methods Type I PPB cases from the International PPB Registry and literature were evaluated using standard statistical methods for outcom

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