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Journal articles on the topic 'Prognostic horizon'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

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1

Lijovic, M., ME Fabiani, J. Bader, and AG Frauman. "Prostate cancer: are new prognostic markers on the horizon?" Prostate Cancer and Prostatic Diseases 3, no. 2 (2000): 62–65. http://dx.doi.org/10.1038/sj.pcan.4500408.

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Bradbury, Jane. "A new prognostic tool on the horizon for breast cancer." Lancet 358, no. 9286 (2001): 989. http://dx.doi.org/10.1016/s0140-6736(01)06151-7.

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Bellocchio, Francesco, Caterina Lonati, Jasmine Ion Titapiccolo, et al. "Validation of a Novel Predictive Algorithm for Kidney Failure in Patients Suffering from Chronic Kidney Disease: The Prognostic Reasoning System for Chronic Kidney Disease (PROGRES-CKD)." International Journal of Environmental Research and Public Health 18, no. 23 (2021): 12649. http://dx.doi.org/10.3390/ijerph182312649.

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Current equation-based risk stratification algorithms for kidney failure (KF) may have limited applicability in real world settings, where missing information may impede their computation for a large share of patients, hampering one from taking full advantage of the wealth of information collected in electronic health records. To overcome such limitations, we trained and validated the Prognostic Reasoning System for Chronic Kidney Disease (PROGRES-CKD), a novel algorithm predicting end-stage kidney disease (ESKD). PROGRES-CKD is a naïve Bayes classifier predicting ESKD onset within 6 and 24 mo

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Sun, Fei, Yingying Lian, Jianlin Wang, Lijun Hu, Judong Luo, and Jingping Yu. "KIF26B in the Prognosis and Immune Biomarking of Various Cancers: A Pan-Cancer Study." Journal of Oncology 2022 (March 22, 2022): 1–12. http://dx.doi.org/10.1155/2022/4829697.

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KIF26B has been identified as an oncogene in several tumors; however, its utility as a prognostic indicator for various cancers has not yet been comprehensively evaluated. Here, we first examined how KIF26B intervenes in thirty-three cancers within the TCGA database, including potential immunological functions, and how it affects the prognosis. Based on the open databases TCGA, TIMER2, GEPIA2, GTEx, CPTAC, and HPA, we found that, when compared with normal tissues, KIF26B is overexpressed in 22 tumor tissues. Following a survival analysis, a relationship between the expression of KIF26B and the

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Kolokolov, Yu, and A. Monovskaya. "Concerning the time horizon of prognostic indicators to be beforehand with local climate changes." IOP Conference Series: Earth and Environmental Science 979, no. 1 (2022): 012124. http://dx.doi.org/10.1088/1755-1315/979/1/012124.

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Abstract The paper researches the time resource to be beforehand with climate changes. The feature of the research consists in the following: the evolutionary properties of the local climate dynamics are considered from the bifurcation analysis, and adaptive properties are considered from the control theory. Then the principal event-driven scenario of the climate change birth is revealed over the period of the reliable meteorological observations; next, the rate of its development is estimated in the context of factually realized precedents; so, time horizons of prognostic indicators are deter

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Goliney, Vladimir A., and Dmitry M. Rosenthal. "US hegemony in Latin America and opportunities to overcome it: horizon 2040." USA & Canada Economics – Politics – Culture, no. 12 (December 15, 2023): 21–32. http://dx.doi.org/10.31857/s2686673023120027.

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This article examines the phenomenon of US hegemony in the Western Hemisphere and explores the possibility of overcoming it by 2040. The authors question the expediency of this measure for the countries within the region. The article identifies key determinants of Inter-American relations development. Among the key threats to Washington's dominance, the authors highlight the strengthening positions of major powers, particularly Brazil and Mexico, as well as China. The study's prognostic nature dictates its methodology, wherein current trends are compared with visions of future world developmen

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Polgár, Csaba, Tibor Major, and János Fodor. "Modern radiotherapy after breast-conserving surgery." Orvosi Hetilap 153, no. 2 (2012): 45–55. http://dx.doi.org/10.1556/oh.2012.29248.

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In the last four decades breast-conserving surgery followed by whole breast irradiation has become the standard of care for the treatment of early-stage (0-I-II) breast carcinoma. With the advent of breast-screening, incidence of breast carcinomas with more favorable prognostic characteristics has increased significantly. This change in the prognostic profile of newly diagnosed breast cancers opened a new horizon for clinical research seeking for individual risk-adapted protocols of breast cancer radiotherapy. Several groups have been tested the efficacy of accelerated (partial or whole) breas

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Tang, Chaozhi, Jiakang Ma, Xueting Wang, et al. "Comprehensive characterization and functional implications of mesenchymal stem cell-related genes in pancancer: A new horizon for immunotherapy." Journal of Clinical Oncology 40, no. 16_suppl (2022): e14577-e14577. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e14577.

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e14577 Background: Accumulated evidence demonstrates that mesenchymal stem cells (MSCs) contribute to tissue regeneration, tumor progression, chemotherapy resistance, and mediate tumor immune escape by modulating the stroma and immunity of the tumor microenvironment. However, little is known about the role of MSCs in cancer patients receiving immunotherapy. Therefore, we investigated the comprehensive characterization of MSC-related genes and their functional implications in pan-cancer immunotherapy. Methods: We performed a pan-cancer analysis of 59 MSC-related genes, which was used to calcula

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Tang, Chaozhi, Jiakang Ma, Xueting Wang, et al. "Comprehensive characterization and functional implications of mesenchymal stem cell-related genes in pancancer: A new horizon for immunotherapy." Journal of Clinical Oncology 40, no. 16_suppl (2022): e14577-e14577. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e14577.

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e14577 Background: Accumulated evidence demonstrates that mesenchymal stem cells (MSCs) contribute to tissue regeneration, tumor progression, chemotherapy resistance, and mediate tumor immune escape by modulating the stroma and immunity of the tumor microenvironment. However, little is known about the role of MSCs in cancer patients receiving immunotherapy. Therefore, we investigated the comprehensive characterization of MSC-related genes and their functional implications in pan-cancer immunotherapy. Methods: We performed a pan-cancer analysis of 59 MSC-related genes, which was used to calcula

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Sekeres, Mikkael A., and Bhumika J. Patel. "Lowering the boom on lower-risk myelodysplastic syndromes." Hematology 2019, no. 1 (2019): 367–72. http://dx.doi.org/10.1182/hematology.2019000040.

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Abstract Lower-risk myelodysplastic syndromes are defined using prognostic scoring systems that incorporate data on bone marrow blast percentage, degree and numbers of cytopenias, and cytogenetic abnormalities. Increasingly, these are incorporating molecular abnormalities to further refine risk. Therapy is geared toward predominating cytopenias, with erythropoiesis-stimulating agents luspatercept and lenalidomide used to ameliorate anemia, romiplostim and eltrombopag tackling thrombocytopenia, and hypomethylating agents and antithymocyte globulin palliating pancytopenia. Newer agents on the ho

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Garrido, Pilar, María Eugenia Olmedo, Ana Gómez, et al. "Treating KRAS-mutant NSCLC: latest evidence and clinical consequences." Therapeutic Advances in Medical Oncology 9, no. 9 (2017): 589–97. http://dx.doi.org/10.1177/1758834017719829.

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KRAS mutations represent one of the most prevalent oncogenic driver mutations in non-small cell lung cancer (NSCLC). For many years we have unsuccessfully addressed KRAS mutation as a unique disease. The recent widespread use of comprehensive genomic profiling has identified different subgroups with prognostic implications. Moreover, recent data recognizing the distinct biology and therapeutic vulnerabilities of different KRAS subgroups have allowed us to explore different treatment approaches. Small molecules that selectively inhibit KRAS G12C or use of immune checkpoint inhibitors based on c

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Yanchuk, Oleksandr, and Roman Shulgan. "PROGNOSTIC EVALUATION OF THE IMPACT OF RESTRICTED HORIZON VISIBILITY ON THE ACCURACY OF POSITION (COORDINATES) OBTAINED WITH GNSS BASED ON EMPIRICAL DATA." Geodesy and cartography 46, no. 2 (2020): 67–74. http://dx.doi.org/10.3846/gac.2020.11191.

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In this research, the practical check of regression equation to calculate the prognostic root mean square error (RMSE) of the final point position of the base line in relation to the initial one has been executed. For the investigation, experimental data from three satellite receivers within two days on 5 points have been used. According to the received results, the regression equation to calculate the RMSE of spatial, planned and height position of the final point of the base line in relation to the initial value has been made. These equations allow executing the prognostic evaluation of accu

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Hug, Eugen B. "Review of skull base chordomas: prognostic factors and long-term results of proton-beam radiotherapy." Neurosurgical Focus 10, no. 3 (2001): 1–5. http://dx.doi.org/10.3171/foc.2001.10.3.12.

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Fractionated proton beam radiotherapy has been used for skull base tumors in the United States since the mid-70s, and more than 300 patients in whom diagnosis of chordoma of the skull base has been made have been treated. The ability to achieve high degrees of radiation dose conformity by using protons has resulted in higher radiation doses than can be delivered with conventional radiotherapy in the base of skull. High target volume doses have led to improved tumor control and patient survival. Side effects such as severe toxicity are acceptable considering the alternatives of uncontrolled tum

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Boykina, E. E., and V. A. Chernov. "Legal Conscience of Teens from the Centennials Generation: a Prognostic Assessment." Psychology and Law 11, no. 1 (2021): 135–49. http://dx.doi.org/10.17759/psylaw.2021110111.

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Adolescence is a sensitive period for setting the groundwork of one's legal conscience on the way to the legal culture of an adult. The article analyses the projected risks for shaping the legal conscience of people for the next 10-20 years using the approach of the modern theories of generational cohorts. For the purpose of "detailed portrayal" of the anticipated image of an adult from the 2030-2040 this article contains the results of 11 studies (on centennials, iGeners, homelanders, digital natives etc.). The disputable traits of the typical representatives of these generations (that can po

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Aslam, Sidra, Anshul Aggarwal, Juhi Gupta, and Sahla Batool. "In-silico studies in Oral Medicine and Radiology." Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology 10, no. 4 (2024): 265–69. https://doi.org/10.18231/j.jooo.2024.052.

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The term in-silico originates from Latin, referring to the use of silicon, a p-block element prominent in computer chips. In the dynamic field of Oral Medicine and Radiology, in-silico studies have become crucial. This branch focuses on diagnosis, treatment planning, prognosis, and maxillofacial imaging. The adoption of model-driven approaches enhances the accuracy of treatment regimes, radiographic interpretations, and prognostic outcomes. The continued evolution of technology promises further integration of in-silico models with experimental and clinical data. This synergy is expected to enh

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Restrepo-Escobar, Mauricio, Paula A. Granda-Carvajal, Daniel C. Aguirre, Johanna Hernández-Zapata, Gloria M. Vásquez, and Fabián Jaimes. "Predictive models of infection in patients with systemic lupus erythematosus: A systematic literature review." Lupus 30, no. 3 (2021): 421–30. http://dx.doi.org/10.1177/0961203320983462.

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Introduction Having reliable predictive models of prognosis/the risk of infection in systemic lupus erythematosus (SLE) patients would allow this problem to be addressed on an individual basis to study and implement possible preventive or therapeutic interventions. Objective To identify and analyze all predictive models of prognosis/the risk of infection in patients with SLE that exist in medical literature. Methods A structured search in PubMed, Embase, and LILACS databases was carried out until May 9, 2020. In addition, a search for abstracts in the American Congress of Rheumatology (ACR) an

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Worku, Tesfaye, Dinesh Bhattarai, Duncan Ayers, et al. "Long Non-Coding RNAs: the New Horizon of Gene Regulation in Ovarian Cancer." Cellular Physiology and Biochemistry 44, no. 3 (2017): 948–66. http://dx.doi.org/10.1159/000485395.

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Long non-coding RNAs (lncRNAs), a class of non-coding transcripts, have recently been emerging with heterogeneous molecular actions, adding a new layer of complexity to gene-regulation networks in tumorigenesis. LncRNAs are considered important factors in several ovarian cancer histotypes, although few have been identified and characterized. Owing to their complexity and the lack of adapted molecular technology, the roles of most lncRNAs remain mysterious. Some lncRNAs have been reported to play functional roles in ovarian cancer and can be used as classifiers for personalized medicine. The in

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Coombs, Catherine C., Tony Dickherber, and Brian D. Crompton. "Chasing ctDNA in Patients With Sarcoma." American Society of Clinical Oncology Educational Book, no. 40 (May 2020): e351-e360. http://dx.doi.org/10.1200/edbk_280749.

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Liquid biopsies are new technologies that allow cancer profiling of tumor fragments found in body fluids, such as peripheral blood, collected noninvasively from patients with malignancies. These assays are increasingly valuable in clinical oncology practice as prognostic biomarkers, as guides for therapy selection, for treatment monitoring, and for early detection of disease progression and relapse. However, application of these assays to rare cancers, such as pediatric and adult sarcomas, have lagged. In this article, we review the technical challenges of applying liquid biopsy technologies t

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Kononov, Evgeniy, Andrey Klyuev, and Mikhail Tashkinov. "Prediction of Technical State of Mechanical Systems Based on Interpretive Neural Network Model." Sensors 23, no. 4 (2023): 1892. http://dx.doi.org/10.3390/s23041892.

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A classic problem in prognostic and health management (PHM) is the prediction of the remaining useful life (RUL). However, until now, there has been no algorithm presented to achieve perfect performance in this challenge. This study implements a less explored approach: binary classification of the state of mechanical systems at a given forecast horizon. To prove the effectiveness of the proposed approach, tests were conducted on the C-MAPSS sample dataset. The obtained results demonstrate the achievement of an almost maximal performance threshold. The explainability of artificial intelligence

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Drałus, Grzegorz, Grzegorz Dec, and Damian Mazur. "One day ahead forecasting of energy generating in photovoltaic systems." ITM Web of Conferences 21 (2018): 00023. http://dx.doi.org/10.1051/itmconf/20182100023.

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The article presents selected methods for forecasting energy generated by a solar system. Short-term forecasts are necessary in planning the work of renewable energy sources and their share in the energy market. Forecasting from the one-day horizon is one of the short-term forecasts. Rear-round prognostic models have been designed using various forecasting methods such as regression, neural networks or time series. On the basis of one day ahead forecasts the accuracy of designed models was assessed. The influence of selected weather factors on forecasts accuracy is also presented, only for mod

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Semyrka, Roman, Michał Maruta, and Andrzej Pasternacki. "PROGNOSTIC ACCUMULATION ZONES FOR OIL AND NATURAL GAS IN THE CRITERIA FOR THE DISTRIBUTION OF PETROPHYSICAL PARAMETERS IN THE MAIN DOLOMITE IN GORZOW-PNIEWY AREA / PROGNOSTYCZNE STREFY AKUMULACJI DLA ROPY NAFTOWEJ I GAZU ZIEMNEGO W KRYTERIACH ROZKŁADU PARAMETRÓW PETROFIZYCZNYCH DOLOMITU GŁÓWNEGO W OBSZARZE GORZÓW-PNIEWY." Archives of Mining Sciences 58, no. 4 (2013): 1111–32. http://dx.doi.org/10.2478/amsc-2013-0076.

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Abstract The carbonate reservoirs are anisotropic environments in terms of both the quantitative and qualitative evaluations of pore space. The oil-and-gas-bearing Main Dolomite horizon shows diversified lithology, facial development and thickness resulting in complicated, fluid capacity-fluid filtration system. This system influences both the evaluation and exploration perspectives in the Zechstein Main Dolomite (Ca2) from the Gorzów-Pniewy area. In order to clarify this problem and to determine the hydrocarbon accumulation perspectives, analysis of petrophysical parameters based upon the por

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Sumner, T., A. Fiore-Gartland, M. Hatherill, R. M. G. J. Houben, T. J. Scriba, and R. G. White. "The effect of new Mycobacterium tuberculosis infection on the sensitivity of prognostic TB signatures." International Journal of Tuberculosis and Lung Disease 25, no. 12 (2021): 1001–5. http://dx.doi.org/10.5588/ijtld.21.0323.

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BACKGROUND: Tests that identify individuals at greatest risk of TB will allow more efficient targeting of preventive therapy. The WHO target product profile for such tests defines optimal sensitivity of 90% and minimum sensitivity of 75% for predicting incident TB. The CORTIS (Correlate of Risk Targeted Intervention Study) evaluated a blood transcriptomic signature (RISK11) for predicting incident TB in a high transmission setting. RISK11 is able to predict TB disease progression but optimal prognostic performance was limited to a 6-month horizon.METHODS: Using a mathematical model, we estimat

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Yu, Justin, Tiffany Pham, Narine Wandrey, Mackenzie Daly, and Sana Karam. "Multimodality Management of EBV-Associated Nasopharyngeal Carcinoma." Cancers 13, no. 23 (2021): 6078. http://dx.doi.org/10.3390/cancers13236078.

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Nasopharyngeal carcinoma (NPC) is a rare cancer of the nasopharyngeal mucosa with a specific geographic predisposition. NPC is often associated with Epstein–Barr Virus (EBV) infection and as a result contains many characteristic biomarkers. Treatment of locally-contained NPC is generally achieved through use of radiotherapy (RT), as part of a multimodality treatment regimen. Induction chemotherapy followed by concurrent RT and platinum-based chemotherapy regimen has emerged as the definitive treatment of choice for locoregionally-advanced NPC. Recently, immunotherapy is finding a role in the t

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Gisterek, I., R. Matkowski, E. Suder, et al. "Prognostic role of c-met tyrosine kinase receptor expression in breast carcinoma." Journal of Clinical Oncology 24, no. 18_suppl (2006): 10552. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.10552.

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10552 Background: Hepatocyte growth factor is a pleotropic growth factor that regulates cell proliferation, survival, tumor angiogenesis and metastasis. Its biological effects are mediated through interaction with its receptor: c-met protein.In this study, we evaluated c-met expression in the homogenous group of 99 patients diagnosed with stage II ductal breast carcinomas (G2, G3). We analyzed 5 and 10-years overall (OS) and disease free survival (DFS). Methods: Microscopic studies were performed on formalin-fixed, paraffin-embedded tumor tissue, obtained during surgery and stained routinely w

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Feder-Sempach, Ewa, Piotr Szczepocki, and Wiesław Dębski. "What if beta is not stable? Applying the Kalman filter to risk estimates of top US companies over the long time horizon." Bank i Kredyt Vol. 54, No. 1 (2023): 25–44. http://dx.doi.org/10.5604/01.3001.0054.5699.

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The main objective of this paper is to examine the Kalman approach to estimate the time-varying CAPM beta on the US stock market over the long time horizon of thirty-one years. We investigate the beta estimates on the basis of three specifications: random walk (RW), mean-reverting process (MR), and random coefficient of the beta parameter (RC) for companies listed on NYSE and NASDAQ in the period 1990–2021. We examine the prognostic power of beta estimates and ranked the results according to criteria of forecast accuracy. In terms of the adopted criteria, the estimation of the beta parameter a

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Carr, Emma, Susan Lerner, Rick Aultman, Ute Weisgerber-Kriegl, and Michael Keating. "Treatment Effect of First Line Rituximab, Fludarabine and Cyclosphosphamide in a Chronic Lymphocytic Leukemia Patient Cohort: An Evaluation of Prognostic Factors, Estimated Life Expectancy and Economic Outcomes." Blood 112, no. 11 (2008): 2396. http://dx.doi.org/10.1182/blood.v112.11.2396.2396.

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Abstract Background: We evaluated the life-time health outcomes and direct costs of first-line rituximab, fludarabine and cyclosphosphamide (R-FC) treatment for chronic lymphocytic leukemia (CLL) patients in US clinical practice, using long-term data from a retrospective cohort comparison (Tam et al., 2008). Additionally, prognostic factors were examined for association with treatment outcomes. Methods: A Cox analysis was conducted to assess for potential heterogeneity and treatment association with baseline prognostic factors. Baseline prognostic factors included: age, gender, beta-2 microglo

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Wahed, Mutaz Abdel, and Salma Abdel Wahed. "Bi-directional AI Framework for Differentiate Psychiatric Disorders and Predicting Symptoms from Drug-Induced Neurotoxicity." Multidisciplinar (Montevideo) 3 (June 28, 2025): 230. https://doi.org/10.62486/agmu2025230.

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Introduction: Diagnosis of mental disorders such as schizophrenia, bipolar disorder, and borderline personality disorder is complicated by the similarity of symptoms, especially in the early stages. The situation becomes even more complicated in the presence of psychoneurological symptoms caused by toxic effects of substances that mimic mental illnesses. There is a need for an intelligent system that can distinguish between these conditions and predict the dynamics of symptoms.Methods: A bidirectional artificial intelligence model was developed, consisting of two modules: a diagnostic classifi

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Xu, Qiushi, Tong Liu, and Junjie Wang. "Radiosensitization-Related Cuproptosis LncRNA Signature in Non-Small Cell Lung Cancer." Genes 13, no. 11 (2022): 2080. http://dx.doi.org/10.3390/genes13112080.

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A new treatment modality targeting cuproptosis is gradually entering the public horizon. Cuproptosis is a new form of regulated cell death distinct from ferroptosis, apoptosis, autophagy, and necrosis. Previous studies have discovered that the copper level varies considerably in various cancers and that an increase in copper content is directly associated with the proliferation and metastasis of cancer cells. In non-small cell lung cancer (NSCLC) after radiation, the potential utility of cuproptosis-related long noncoding RNAs (lncRNAs) is still unclear. This research aimed to develop a predic

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Antonowicz, Paweł, Kamila Migdał-Najman, and Krzysztof Najman. "Financial predictors of corporate insolvency - assessment of the forecast horizon of variables in models of early warning against corporate bankruptcy." e-mentor 101, no. 4 (2023): 39–44. http://dx.doi.org/10.15219/em101.1626.

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The authors of the study put forward a hypothesis that it is possible to extend the forecast period for the models of discriminant analysis used to assess the risk of enterprise bankruptcy, focusing on the components of these functions in the form of one-dimensional predictors, i.e. the indicators most frequently included in the discriminant functions developed in Poland. Early warning about the growing risk of bankruptcy would be very valuable for any company. The dataset was constructed from all enterprises in Poland that went bankrupt in the years 2007-2013, which was the end of the researc

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Park, Mi-Suk. "Review of Mass-Forming Intrahepatic Cholangiocarcinoma." Korean Journal of Abdominal Radiology 6, no. 1 (2022): 1–11. http://dx.doi.org/10.52668/kjar.2022.00150.

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The incidence of intrahepatic cholangiocarcinoma (iCCA) is highest in Eastern countries, such as Thailand, South Korea, and China, but its incidence and mortality are increasing worldwide. Over recent decades, the worldwide age-standardized incidence for iCCA has been steadily increasing, whereas that for perihilar CCA and distal CCA has been decreasing. The macroscopic growth pattern of CCA is somewhat different according to the anatomic location of the tumor. iCCA can show three main patterns of growth: mass forming, periductal infiltrating, and intraductal growing. Morphologic classificatio

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Dreja, Hanna S., Julie Ayton, David Bruce, et al. "Knockout validation of antibodies to Ki67: a marker for cellular proliferation." Journal of Immunology 198, no. 1_Supplement (2017): 213.10. http://dx.doi.org/10.4049/jimmunol.198.supp.213.10.

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Abstract At Abcam, providing a high level of validation has always been a priority and our strategies are constantly evolving as new technologies are developed. The recent knockout (KO) validation initiative, made possible through a partnership with Horizon Discovery and the use of their CRISPR/Cas9 KO cell lines, addresses both antibody specificity and reproducibility on a large scale. Ki67 is a proliferation marker and determining its expression levels has prognostic and predictive values in cancer (1–5). Hence, it is critical that antibodies used to target Ki67 are highly specific. This stu

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Stauder, S., and P. M. Peloso. "POS1125 DUAL ENERGY CT HAS PROGNOSTIC VALUE IN GOUT BEYOND STANDARD CLINICAL MEASURES: A BEST EVIDENCE SYNTHESIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 841.2–842. http://dx.doi.org/10.1136/annrheumdis-2021-eular.872.

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Background:Dual Energy CT Scan (DECT) can detect monosodium urate crystal deposits in multiple tissues. EULAR gout guidelines (Richette, 2020) recognized the value of DECT in making a clinical diagnosis when joint aspiration is difficult. DECT shows crystal deposits in almost 50% of gout patients without tophi (Dalbeth, 2017). Tophi are known to predict all-cause and cardiovascular mortality (Vincent 2017, Perez-Ruiz 2013) and it is plausible that DECT could as well. A prognostic measure should be reliable and valid. DECT validity would be evident for death, disability and distress.Objectives:

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Devitt, Michael E., and Robert Dreicer. "Evolving Role of Genomics in Genitourinary Neoplasms." Acta Medica Academica 48, no. 1 (2019): 68. http://dx.doi.org/10.5644/ama2006-124.243.

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<p>The aim of this article is to review the current role of genomic testing in the risk, prognosis, and treatment of genitourinary malignancies. The authors selected guidelines, publications, and abstracts relevant to the current and emerging role of genomics in genitourinary cancers. The risk of developing genitourinary cancer can be stratified based on genomic data. Prostate cancer has the strongest degree of heritability, with <em>BRCA1/2 </em>and <em>HOXB13 </em>mutations playing a role in familial disease. Genomic data is on the verge of informing treatment d

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Aboian, I. A., E. N. Fedotova, A. N. Shevchenko, et al. "Current biomarkers of prostate cancer." Research and Practical Medicine Journal 8, no. 4 (2021): 96–108. http://dx.doi.org/10.17709/2410-1893-2021-8-4-10.

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Prostate cancer is one of the most common malignancies in men. Early detection of prostate cancer is largely determined by the widely used prostate specific antigen (PSA) blood test. However, as a diagnostic and prognostic test of prostate cancer, PSA has limited specificity, sensitivity and leads to hyper or underdiagnosis, which, in turn, can lead to excessive treatment. There fore, it is very important to develop diagnostic markers that can be used to determine prostate cancer at an early stage of development, assess the possible progression of the disease and prescribe optimal therapy. Sig

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Chernyakhovsky, S. F. "On the crisis of the design and prognostic ability of Western modern political philosophy." Полис. Политические исследования, no. 2 (March 26, 2025): 180–91. https://doi.org/10.17976/jpps/2025.02.13.

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Time is compressed and accelerated, the horizon of the vision of the future turns out to be deformed and, as it were, flattened to what seems to be modernity - as a moment of belonging to the present. And it is precisely to this - mental causes and their consequences - that the collective monograph “The image of the future in political thought of the 20th - early 21st centuries” (Fedorova, M.M. (Ed.). Moscow; St. Petersburg: Center for Humanitarian Initiatives, 2024) is dedicated. The team of authors offers an interesting conceptual study, a review on the topic of images of the future. The pap

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Anagiannis, Ioannis, Nikolaos Nikolakis, and Kosmas Alexopoulos. "Energy-Based Prognosis of the Remaining Useful Life of the Coating Segments in Hot Rolling Mill." Applied Sciences 10, no. 19 (2020): 6827. http://dx.doi.org/10.3390/app10196827.

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The field of prognostic maintenance aims at predicting the remaining time for a system or component to continue being used under the desired performance. This time is usually named as Remaining Useful Life (RUL). The current study proposes a novel approach for the RUL estimation of coating segments placed on a hot rolling mill machine. A prediction method was developed, providing real-time updates of the RUL prediction during the rolling milling process. The proposed approach performs energy analysis on measurements of segment surface temperatures and hydraulic forces. It uses nonparametric st

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Radocha, Jakub, Vladimír Maisnar, Ludek Pour, et al. "Multiple Myeloma R-ISS Prognostic Stratification System in Real Life Population." Blood 128, no. 22 (2016): 3333. http://dx.doi.org/10.1182/blood.v128.22.3333.3333.

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Abstract Introduction: Revised prognostic scoring system R-ISS (standard ISS plus cytogenetic changes) has been introduced as a possible tool for evaluation of patients with multiple myeloma. This system is based on pooled data from various clinical trials but has not been validated in patients´ population outside the clinical trial setting. Aim: To evaluate clinical relevance of R-ISS in real life population of multiple myeloma patients. Methods: Registry of monoclonal gammopathies (RMG) was established in 2007 and has become one of the flagship projects of the Czech Myeloma Group. The regist

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Ragusa, Rosalia, Vincenzo Guardabasso, Maria Alessandra Bellia, Filippo Piana, and Rosalba Quattrocchi. "OP45 HTA And Gender Medicine: Time To Take Action!" International Journal of Technology Assessment in Health Care 39, S1 (2023): S12. http://dx.doi.org/10.1017/s026646232300079x.

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IntroductionGender medicine responds to the need for a reassessment of the medical-scientific approach in a gender perspective, to increase knowledge of the different aspects underlying gender differences and the appropriateness/ effectiveness of health interventions.MethodsA policy review of documents prepared by the Italian Ministry of Health on gender medicine was carried out, to investigate the possible areas of intervention of health technology assessment in the development of this interdisciplinary dimension. The areas of highest priority for action have been identified.ResultsIn Italy,

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Horvat, Christopher M., Amie J. Barda, Eddie Perez Claudio, et al. "Interoperable Models for Identifying Critically Ill Children at Risk of Neurologic Morbidity." JAMA Network Open 8, no. 2 (2025): e2457469. https://doi.org/10.1001/jamanetworkopen.2024.57469.

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ImportanceDecreasing mortality in the field of pediatric critical care medicine has shifted practicing clinicians’ attention to preserving patients’ neurodevelopmental potential as a main objective. Earlier identification of critically ill children at risk for incurring neurologic morbidity would facilitate heightened surveillance that could lead to timelier clinical detection, earlier interventions, and preserved neurodevelopmental trajectory.ObjectivesTo develop machine-learning models for identifying acquired neurologic morbidity in hospitalized pediatric patients with critical illness and

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Saßmannshausen, Marlene, Charlotte Behning, Jonas Weinz, et al. "Characteristics and Spatial Distribution of Structural Features in Age-Related Macular Degeneration: A MACUSTAR Study Report." Ophthalmology Retina 7, no. 5 (2023): 420–30. https://doi.org/10.1016/j.oret.2022.12.007.

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PurposeTo report the prevalence and topographic distribution of structural characteristics in study participants with age-related macular degeneration (AMD) and controls in the cross-sectional study part of the MACUSTAR study (ClinicalTrials.gov Identifier: NCT03349801).DesignEuropean, multicenter cohort study.SubjectsOverall, 301 eyes of 301 subjects with early (n = 34), intermediate (n = 168), and late AMD (n = 43), as well as eyes without any AMD features (n = 56).MethodsIn study eyes with intermediate AMD (iAMD), the presence of structural AMD biomarkers, including pigm

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Tong, K. B., E. Chen, G. Brink, R. Bender, F. de Snoo, and J. Malin. "Cost-effectiveness of targeting chemotherapy with the 70-gene prognostic signature in early-stage breast cancer (ESBC) patients." Journal of Clinical Oncology 27, no. 15_suppl (2009): 6570. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.6570.

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6570 Background: The 70-gene microarray test (MammaPrint) has been shown to provide additional prognostic information to clinicopathologic risk assessment for women ESBC; however, the cost-effectiveness of this strategy is not well understood. Methods: The objective of this analysis was to estimate the incremental benefits, costs, and cost-effectiveness of the treatments guided by the 70-gene signature versus Adjuvant! Software (AS) to decide on the use of adjuvant chemotherapy for women ≤61 years with lymph node negative, HER-2 negative ESBC with estrogen receptor (ER) positive or negative di

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Keam, Bhumsuk, Olena Gorobets, Vincent Vinh-Hung, and Seock-Ah Im. "Lymph Node Ratio after Neoadjuvant Chemotherapy for Stage II/III Breast Cancer: Prognostic Value Measured with Gini’s Mean Difference of Restricted Mean Survival Times." Cancer Informatics 20 (January 2021): 117693512110516. http://dx.doi.org/10.1177/11769351211051675.

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Restricted mean survival time (RMST), recommended for reporting survival, lacks a tool to evaluate multilevel factors. The potential of the Gini’s mean difference of RMSTs (Δ) is explored in a comparison of a lymph node ratio-based classification (LNRc) versus a number-based classification (ypN) applied to stage II/III breast cancer patients who received neoadjuvant chemotherapy and underwent axillary dissection. Number of positive nodes ( npos) classified patients into ypN0, npos = 0, ypN1, npos = [1,3], ypN2, npos = [4,9], and ypN3, npos ⩾ 10. Ratio npos/( number of nodes examined) of 0, (0,

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Lesur, Olivier, Yves Berthiaume, Gilbert Blaise, et al. "Acute Respiratory Distress Syndrome: 30 Years Later?" Canadian Respiratory Journal 6, no. 1 (1999): 71–86. http://dx.doi.org/10.1155/1999/812476.

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Acute respiratory distress syndrome (ARDS) was first described about 30 years ago. Modern definitions and statements have recently been proposed to describe ARDS accurately, but none is perfect. Diffuse alveolar damage is the basic pathological pattern most commonly observed in ARDS, and the term includes permeability edema. The alveolar epithelium of the alveolar-capillary barrier is clearly a key component requiring repair, given its multipotent functional activity. Lung inflammation and neutrophil accumulation are essential markers of disease in ARDS, and a wide variety of pro- and anti-inf

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Bhardwaj, Prarthna V., Yue Wang, Elizabeth Brunk, Philip M. Spanheimer, and Yara G. Abdou. "Advances in the Management of Early-Stage Triple-Negative Breast Cancer." International Journal of Molecular Sciences 24, no. 15 (2023): 12478. http://dx.doi.org/10.3390/ijms241512478.

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Triple-negative breast cancer (TNBC) is a subtype of breast cancer with both inter- and intratumor heterogeneity, thought to result in a more aggressive course and worse outcomes. Neoadjuvant therapy (NAT) has become the preferred treatment modality of early-stage TNBC as it allows for the downstaging of tumors in the breast and axilla, monitoring early treatment response, and most importantly, provides important prognostic information that is essential to determining post-surgical therapies to improve outcomes. It focuses on combinations of systemic drugs to optimize pathologic complete respo

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Blakstad, H., E. E. Mendoza Mireles, L. C. Heggebø, et al. "P11.75.B PSEUDOPROGRESSION IN A REAL-WORLD GLIOBLASTOMA COHORT: INCIDENCE, MANAGEMENT, PROGNOSTIC IMPACT, AND ASSOCIATED FACTORS." Neuro-Oncology 25, Supplement_2 (2023): ii93. http://dx.doi.org/10.1093/neuonc/noad137.309.

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Abstract BACKGROUND Radiotherapy remains a cornerstone in glioblastoma (GBM) management. A continued and unmet need in neuro-oncology is efficient non-invasive methods to differentiate post-radiation magnetic resonance imaging (MRI) changes from progressive disease (PD) in GBM patients. The clinical challenge is two-sided; avoid termination of effective therapy in case of pseudoprogression (PsP) and continuation of ineffective therapy in case of PD. We retrospectively assessed incidence, management, prognostic impact, and associated factors with PsP in a real-world GBM patient cohort. MATERIAL

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Virrantaus, Hélène, Helena Liira, Tatiana Posharina, et al. "Prognosis of patients with long COVID symptoms: a protocol for a longitudinal cohort study at a primary care referred outpatient clinic in Helsinki, Finland." BMJ Open 13, no. 10 (2023): e072935. http://dx.doi.org/10.1136/bmjopen-2023-072935.

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IntroductionAfter COVID-19, many continue to experience persistent debilitating symptoms, that is, long COVID. Its most prevalent symptoms are chest pain, difficulties with breathing, painful muscles, ageusia or anosmia, tingling extremities and general tiredness. This paper describes the protocol of the Long COVID Cohort Study to assess the prognosis and prognostic determinants of patients with long COVID by implementing patient-reported outcome measures (PROMs), patient-reported experience measures (PREMs) and clinical examinations during a 1-year follow-up.Methods and analysisThis is a pros

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Piotrowski, Paweł, Mirosław Parol, Piotr Kapler, and Bartosz Fetliński. "Advanced Forecasting Methods of 5-Minute Power Generation in a PV System for Microgrid Operation Control." Energies 15, no. 7 (2022): 2645. http://dx.doi.org/10.3390/en15072645.

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This paper concerns very-short-term (5-Minute) forecasting of photovoltaic power generation. Developing the methods useful for this type of forecast is the main aim of this study. We prepared a comprehensive study based on fragmentary time series, including 4 full days, of 5 min power generation. This problem is particularly important to microgrids’ operation control, i.e., for the proper operation of small energy micro-systems. The forecasting of power generation by renewable energy sources on a very-short-term horizon, including PV systems, is very important, especially in the island mode of

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Tusheva, V. V. "Conceptual approaches to opening the essence of scientific-research culture of the future music teacher." Musical art in the educological discourse, no. 2 (2017): 31–38. http://dx.doi.org/10.28925/2518-766x.20172.3138.

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Actuality of the problem of development of scientific-research culture of future music teachers is reasonable in the article, that it is related to the terms of post of nonclassical science, for which the processes of coevolution and globalization are common, expansions of gnosiology horizon, isomorphism of scientific and cultural dynamics. In this context it is significant rethinking of pedagogical impact of science on personal development of future music teachers, purposeful formation of their scientific-research culture as the capacity for mental analytical and synthetic, evolutionary progn

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Jagirdar, Jaishree. "Application of Immunohistochemistry to the Diagnosis of Primary and Metastatic Carcinoma to the Lung." Archives of Pathology & Laboratory Medicine 132, no. 3 (2008): 384–96. http://dx.doi.org/10.5858/2008-132-384-aoittd.

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Abstract Context.—Immunohistochemistry is a very valuable and often used tool in the differential diagnosis of lung carcinomas whether primary or secondary to the lung. The most useful application is in distinguishing primary lung tumors from metastatic tumors to the lung from common sites (colon, breast, prostate, pancreas, stomach, kidney, bladder, ovaries, and uterus). Immunohistochemistry also aids in the separation of small cell carcinoma from non–small cell carcinoma and carcinoids particularly in small biopsy specimens limited by artifact. Although there is no “lung-specific tumor marke

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Zewde, Makda Getachew, George Morales, Isha Gandhi, et al. "Prognostic Value of Elafin in Acute Graft-Versus-Host Disease." Blood 138, Supplement 1 (2021): 3900. http://dx.doi.org/10.1182/blood-2021-154302.

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Abstract Background: A major cause of mortality in patients receiving hematopoietic stem cell transplantation (HCT) is acute graft-versus-host disease (GVHD), a multiorgan disorder that includes the skin, liver and gastrointestinal tract. We have previously identified elafin, a protease inhibitor overexpressed in inflamed epidermis, as a diagnostic biomarker of GVHD in the skin, the most commonly involved GVHD organ. However, our initial study was limited to a subset of patients with isolated skin GVHD. The main driver of nonrelapse mortality (NRM) in HCT patients is GI GVHD. Two biomarkers, R

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