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Bremer, Gerardus Leonardus. "Tumour stroma in cervical cancer, novel prognostic parameters." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=8350.
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Raymond, Wendy Ann. "Immunohistochemcial prognostic parameters in breast carcinoma / Wendy Ann Raymond." 1990, 1990. http://hdl.handle.net/2440/38405.
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胡夕春 and Xichun Hu. "Study on the use of potential prognostic parameters in breast cancer patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B30158138.
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Hu, Xichun. "Study on the use of potential prognostic parameters in breast cancer patients." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23440119.
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Kato, Ayako. "Prognostic Value of Quantitative Parameters of ¹⁸F-FDG PET/CT for Patients With Angiosarcoma." Kyoto University, 2020. http://hdl.handle.net/2433/259007.
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Puertas, Monica A. "Statistical and Prognostic Modeling of Clinical Outcomes with Complex Physiologic Data." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5106.
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Laboratory tests are a primary resource for diagnosing patient diseases. However, physicians often make decisions based on a single laboratory result and have a limited perspective of the role of commonly-measured parameters in enhancing the diagnostic process. By providing a dynamic patient profile, the diagnosis could be more accurate and timely, allowing physicians to anticipate changes in the recovery trajectory and intervene more effectively.
The assessment and monitoring of the circulatory system is essential for patients in intensive care units (ICU). One component of this system is the platelet count, which is used in assessing blood clotting. However, platelet counts represent a dynamic equilibrium of many simultaneous processes, including altered capillary permeability, inflammatory cascades (sepsis), and the coagulation process. To characterize the value of dynamic changes in platelet count, analytical methods are applied to datasets of critically-ill patients in (1) a homogeneous population of ICU cardiac surgery patients and (2) a heterogeneous group of ICU patients with different conditions and several hospital admissions.
The objective of this study was to develop a methodology to anticipate adverse events using metrics that capture dynamic changes of platelet counts in a homogeneous population, then redefine the methodology for a more heterogeneous and complex dataset. The methodology was extended to analyze other important physiological parameters of the circulatory system (i.e., calcium, albumin, anion gap, and total carbon dioxide). Finally, the methodology was applied to simultaneously analyze some parameters enhancing the predictive power of various models.
This methodology assesses dynamic changes of clinical parameters for a heterogeneous population of ICU patients, defining rates of change determined by multiple point regression and by the simpler fixed time parameter value ratios at specific time intervals. Both metrics provide prognostic information, differentiating survivors from non-survivors and have demonstrated being more predictive than complex metrics and risk assessment scores with greater dimensionality.
The goal was to determine a minimal set of biomarkers that would better assist care providers in assessing the risk of complications, allowing them alterations in the management of patients. These metrics should be simple and their implementation would be feasible in any environment and under uncertain conditions of the specific diagnosis and the onset of an acute event that causes a patient's admission to the ICU.
The results provide evidence of the different behaviors of physiologic parameters during the recovery processes for survivors and non-survivors. These differences were observed during the first 8 to 10 days after a patient's admission to the ICU. The application of the presented methodology could enhance physicians' ability to diagnose more accurately, anticipate changes in recovery trajectories, and prescribe effective treatment, leading to more personalized care and reduced mortality rates.
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RUGGERONE, BEATRICE. "OXIDATIVE-ANTIOXIDATIVE COMPOUNDS AND LIPID PARAMETERS AS POTENTIAL DIAGNOSTIC AND PROGNOSTIC MARKERS IN ANIMALS WITH SIRS." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/619500.
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Nowadays in veterinary medicine the discrimination between an inflammatory status and a systemic inflammatory response syndrome (SIRS) sometimes related to an infectious disease and with a poorer prognosis, could be difficult, both for the clinicians and the clinical pathologists. An early diagnosis would permit to avoid unnecessary use of antibiotics (mainly to contain the problem of antibiotic resistance) and to establish an appropriate monitoring plan.
The aim of the two first described works was to validate in horses the Paraoxonase-1 (PON-1), a negative acute phase protein already used in dogs; 120 healthy horses of different sex, age and breed were enrolled; then, this protein was evaluated as a possible diagnostic and prognostic markers of SIRS in this species; PON-1 did not seem to be useful to this aim. The prognostic value was not evaluable because of the small amount of survivors in the SIRS group that did not permit a serial evaluation of PON-1 values.
The second part of the thesis is about the Protein Carbonyls (PCOs), that are already used as sepsis markers in humans; a Western Blotting method was initially validated to detect PCOs in canine serum from healthy patients; then, a spectrophotometric method, that could be cheaper and faster than the first one, was employed. With this method, serum from healthy dogs and from dogs with septic or non-septic inflammation was used to measure PCOs. Results between groups were compared to evaluate if PCOs could be considered as possible diagnostic markers of sepsis in association with PON-1 and C-reactive protein (CRP). This marker seemed to be useful to distinguish dogs with sepsis from dogs with sterile inflammation or healthy, but not to give prognostic information.
An increase in the amount of the enrolled dogs would consent to enforce the hypothesis that PCOs could become a reliable support to diagnose sepsis.
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VARRENTI, MARISA. "PROGNOSTIC PERFORMANCE OF CLINICAL PRESENTATION AND CARDIAC MAGNETIC RESONANCE IMAGING PARAMETERS IN PATIENTS WITH ACUTE MYOCARDITIS." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/392357.
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BACKGROUND: L'identificazione di marcatori affidabili associati a eventi dopo una miocardite acuta (AM) è clinicamente rilevante per pianificare un futuro follow-up. Abbiamo cercato di chiarire la performance prognostica dei marcatori di risonanza magnetica cardiaca (CMRI) precedentemente descritti, tra cui l'aumento tardivo del gadolinio settale (LGE), rispetto all'evidenza della frazione di eiezione ventricolare sinistra (LVEF) <50% sulla CMRI basale, rispetto alla presentazione clinica complicata (CCP) della AM (definita come la presenza di aritmie ventricolari sostenute [SVT] o LVEF <50% al primo ecocardiogramma di presentazione fulminante).
METODI: Abbiamo valutato 248 pazienti AM con insorgenza di sintomi cardiaci <30 giorni prima del ricovero, aumento della troponina e CMRI coerente con la diagnosi di miocardite (tempo mediano dal ricovero alla CMRI di 6 giorni). I pazienti sono stati raccolti retrospettivamente tra febbraio 2006 e aprile 2019 da 6 ospedali Lombardi con un follow-up mediano di 1708 giorni (primo - terzo quartile [Q1-Q3], 1000-2751). Abbiamo valutato la performance prognostica di LGE settale vs. LVEF<50% su CMRI vs. CCP.
RISULTATI: La popolazione dello studio aveva un'età mediana di 34 anni (Q1-Q3: 23-41) con una prevalenza maschile dell'87,1% e una LVEF mediana del 61% (Q1-Q3, 55-66%) alla CMRI basale. Tredici pazienti (5,2%) hanno sperimentato almeno un evento cardiaco maggiore (tra cui morte cardiaca, trapianto di cuore (N=1), arresto cardiaco resuscitato (N=3), SVT (N=5), o ricovero per insufficienza cardiaca (N=5). Tra questi 13 pazienti, 10 (76,9%) avevano LGE settale, 8 (61,5%) avevano LVEF<50%, su CMRI, e 12 (92,3%) avevano un CCP. La migliore performance per questi marcatori prognostici era il valore predittivo negativo (NPV) che variava tra 0,98 e 0,99 per CCP, mentre il valore predittivo positivo era basso, tra 0,14 e 0,25 per LVEF<50%.
CONCLUSIONI: Abbiamo confermato che il tasso di eventi cardiaci maggiori dopo una AM è relativamente basso, e LGE settale, LVEF<50% su CMRI, e CCP sono significativamente associati agli eventi nel follow-up. Il risultato più rilevante è l'alto NPV di questi marcatori per identificare i pazienti senza eventi dopo una AM. Questa osservazione può aiutare i medici a monitorare i pazienti dopo una AM ed impostare un corretto monitoraggio nel follow-up sulla base di tali dati all'esordio.<br>BACKGROUND: Identifying reliable markers associated with events after acute myocarditis (AM) is clinically relevant to planning a future follow-up. We aimed to clarify the prognostic performance of previously described cardiac magnetic resonance imaging (CMRI) markers including septal late gadolinium enhancement (LGE), versus evidence of left ventricular ejection fraction (LVEF)<50% on baseline CMRI, vs. complicated clinical presentation (CCP) of AM (defined as the presence of sustained ventricular arrhythmias [SVT] or LVEF <50% on the first echocardiogram of fulminant presentation).
METHODS: We assessed 248 AM patients with onset of cardiac symptoms <30 days before admission, increased troponin, and CMRI consistent with myocarditis (median time from admission to CMRI of 6 days). The patients were retrospectively collected between February 2006 and April 2019 from 6 hospitals with a median follow-up of 1708 days (first to third quartile [Q1-Q3], 1000-2751). We assessed the prognostic performance of septal LGE vs. LVEF<50% on CMRI vs. CCP.
RESULTS: The study population had a median age of 34 years (Q1-Q3: 23-41) with a male prevalence of 87.1% and a median LVEF of 61% (Q1-Q3, 55-66%) on baseline CMRI. Thirteen patients (5.2%) experienced at least one major cardiac event (including cardiac death, heart transplantation (N=1), aborted cardiac death (N=3), SVT (N=5), or heart failure hospitalization (N=5). Among these 13 patients, 10 (76.9%) had septal LGE, 8 (61.5%) had LVEF<50%, on CMRI, and 12 (92.3%) had a CCP. The best performance for these prognostic markers was the negative predictive value (NPV) ranging between 0.98 and 0.99 for CCP, while predictive value was low, ranging between 0.14 and 0.25 for LVEF<50%.
CONCLUSIONS: We confirmed that the rate of major cardiac events after an AM is relatively low, and septal LGE, LVEF<50% on CMRI, and CCP are significantly associated with events. The most relevant finding is the high NPV of these markers to identify patients without events after an AM. This observation can help clinicians to monitor the patients after an AM, in fact, patients without these markers had an uneventful follow-up.
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Anciaux, Maëlle. "Prognostic value of macro- and microenvironment parameters in esophageal cancer: Exploration of candidate biomarkers at morphological, histopathological and molecular levels." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/312668.
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Le cancer de l’œsophage est un cancer particulièrement agressif, avec 450 000 nouveaux cas par an dans le monde. Malgré les récentes innovations thérapeutiques en oncologie, la radiochimiothérapie reste le traitement standard dans ce cancer. Ce traitement lourd est pourtant peu efficace, puisque la survie des patients 5 ans après le diagnostic atteint seulement 20%. Une meilleure connaissance des mécanismes moléculaires ainsi que de nouveaux marqueurs pronostics sont nécessaires afin de réaliser une avancée significative dans la compréhension du cancer de l’œsophage. L’objectif de ce travail concerne l’investigation de nouveaux paramètres pronostiques, macro- ou microenvironnementaux.Dans ce cadre, nous avons investigué l’impact de la composition corporelle et, plus particulièrement, de la qualité du tissu adipeux des patients sur leur survie générale. Les patients souffrant d’un cancer de l’œsophage présentent en général un statut nutritionnel complexe :l’obésité est un facteur de risque de développement d’un adénocarcinome de l’œsophage, tandis que les carcinomes épidermoïdes se développent fréquemment chez des patients malnutris. Nous avons montré que l’atténuation du tissu graisseux au CT-scan a un impact pronostique important. Spécifiquement, une faible densité de la graisse sous-cutanée et viscérale sont des facteurs pronostiques bénéfiques majeurs. Des résultats similaires ont été publiés pour d’autres cancers digestifs, notamment par notre équipe pour le cancer colorectal métastatique. Cependant, les mécanismes biologiques sous-tendant les variations de densité de ces tissus graisseux restent encore incertains. Un tissu graisseux de haute densité refléterait des adipocytes beiges, pauvres en triglycérides et métaboliquement plus actifs. Alors que des phénomènes extrinsèques à la tumeur pourraient amorcer ce phénomène, les facteurs sécrétés par la tumeur pourraient empirer ce processus et impacter l’état de santé général du patient. Nos résultats suggèrent que les traitements pourraient également aggraver ce mécanisme. L’analyse d’échantillons sanguins et de biopsies graisseuses de patients souffrant de cancers gastro-intestinaux nous permettra de dévoiler des marqueurs associés à la variation de densité graisseuse et de faire la lumière sur les mécanismes biologiques impliqués.Depuis quelques années, les motifs histopathologiques de croissance tumorale ont été l’objet de plusieurs études. Associés aux mutations génétiques de la tumeur mais aussi à son microenvironnement, ces motifs de croissance constituent le reflet de processus oncogéniques complexes. Nous avons d’abord exploré l’impact pronostique des motifs histopathologiques de croissance tumorale œsophagienne sur deux cohortes de patients. Nous avons confirmé l’impact pronostique négatif des tumeurs infiltrantes par rapport aux tumeurs expansives. Les tumeurs infiltrantes étaient également plus fréquemment associées à un Stade T et N plus avancés, ainsi qu’à la présence d’emboles lymphovasculaires et d’infiltrations péri-nerveuses. Nous avons ensuite exploré les voies de signalisation classiquement dérégulées dans la carcinogenèse sur la cohorte composée de données publiques ;ces analyses nous ont permis d’identifier l’angiogenèse, la transition épithélio-mésenchymateuse et l’inflammation comme étant surexprimées dans les tumeurs infiltrantes. Nous avons pu identifier OLR1, SFRP4 et CXCL9 comme étant trois gènes intéressants à investiguer pour chacune de ces voies, respectivement.Ces résultats n’ont pas été confirmés par qPCR dans la cohorte de validation. La qualité de l’ARN et le traitement pré- opératoire de ces patients ont réduit le nombre de patients analysables et vraisemblablement contribué à un biais important d’expression des mécanismes biologiques. Une analyse plus extensive de ces trois voies de signalisation pourrait distinguer des acteurs importants du développement de ces motifs de croissance tumorale.En conclusion, ce travail exploratoire a permis de définir plusieurs acteurs du pronostic des patients atteints d’un cancer de l’œsophage. Des analyses moléculaires supplémentaires permettront d’aborder les voies biologiques sous- tendant le développement des motifs histopathologiques de croissance tumorale, d’une part et de variation de densité du tissu graisseux, d’autre part. Ce travail permettra de dévoiler des aspects complexes et encore peu étudiés de l’agressivité des tumeurs œsophagiennes.<br>Doctorat en Sciences biomédicales et pharmaceutiques (Médecine)<br>info:eu-repo/semantics/nonPublished
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Al-Qahtani, Khalid Hussain. "Detection of human papillomavirus in primary site of oraloropharyngeal cancer and in cervical lymph nodes : correlation with clinico-pathological parameters and prognostic significance." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=83960.
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Objectives. (1) To Determine the presence of HPV 6, 11, 16, 18, 31, 33, 35, 52b, 58 subtypes in resected oral/oropharyngeal SCCA cancer and associated lymph nodes. (2) To Determine if a relationship exists between koilocytosis, tumor grade, stage, or prognosis.<br>Methods. Retrospective analysis and pathology review of patients with SCCA of the oral cavity at McGill in the last 5 years was performed. Age at diagnosis, risk factors, tumor stage, grade, koilocytosis, treatment, outcome, and presence of HPV by PCR were analysed.<br>Results. 199 patients included were included in the analyses; 5 years mortality was 18.5%. 146 cases reviewed by pathology revealed 67% koilocytosis. One sample was positive for HPV subtype 35 as determined by PCR. Radiotherapy (p<0,5) and complications from radiotherapy (p<0.5) significantly affected survival.<br>Conclusions. Many oral SCCA's do not contain HPV 6, 11, 16, 18, 31, 33, 35, 52b, 58 subtypes. Given the high prevelence of koilocytosis, probe for other subtypes should be utilized. Mortality rates and survival are similar to those published in the literature. The presence of koilocytosis, it is not related grade, stage or prognosis. Only radiotherapy and its complications affect survival.
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Begum, Mubeena. "Gene expression profiles and clinical parameters for survival prediction in stage II and III colorectal cancer." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001554.
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Grabowski, Pawel. "Telomere length as prognostic parameter in chronic lymphocytic leukemia." Doctoral thesis, Umeå universitet, Patologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-39463.
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B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia among the adult population in western countries and accounts for 30-40% of all leukemias. With survival time ranging from months to decades, the clinical course of individual CLL patients is highly variable. This heterogeneity and in the end the need for means to identify the patients with less favorable disease has encouraged the search for biomarkers that can predict the prognosis. Telomeres are repetitive structures protecting the chromosomal endings and shorten at each cell division. Telomere length (TL) has been indicated as a prognostic factor both in hematological malignancies and solid tumors. In B-CLL, TL is associated with mutation status of the immunoglobulin heavy chain variable (IGHV) gene and with clinical course. In the present thesis the main aim was to evaluate TL as a biomarker in B-CLL using a quantitative PCR-based method for TL determination. In paper I, TL was shown to be a prognostic factor for stage A and stage B/C patients, whereas IGHV mutation status predicted outcome only in stage A patients. Moreover, IGHV mutated CLL cases were subdivided by TL into two groups with different prognosis, a subdivision not seen for unmutated cases. Interestingly, the IGHV-mutated group with short telomeres had en overall survival close to that of the unmutated cases. Thus, a combination of IGHV mutation status and telomere length gave an improved subclassification of CLL identifying previously unrecognized patient groups with different outcomes. TL correlates with cellular origin of B-cell malignancies in relation to the germinal center (GC). In paper II different B-cell lymphoma/leukemia subtypes were analyzed. Shortest telomeres were found in IGHV unmutated CLLs, differing significantly from IGHV mutated cases. Contrary to this, mantle cell lymphomas (MCL) demonstrated similar TL regardless of IGHV mutation status. TL differed significantly between GC-like and non-GC-like diffuse large B-cell lymphomas (DLBCL) and follicular lymphomas (FL) had shorter telomeres than GC-like DLBCL. Hairy cell leukemias, which display Ig gene intraclonal heterogeneity, had longer telomeres than FLs and non-GC-DLBCL, but shorter than GC-DLBCL. In conclusion, TL seemed not to simply correlate with GC origin. Paper III presents a B-CLL cohort assessed for TL, genomic aberrations, IGHV mutation status, CD38 and ZAP-70 expression. An inverse correlation existed between TL and IGHV homology, CD38 and ZAP-70 expression. The presence of genomic aberrations was similar among patients regardless of TL. In contrast, 13q deletion, a favorable biomarker, was more frequent in patients with long telomeres, while 11q and 17p deletions (markers of less favorable outcome) were more frequent in the subgroup with short telomeres. In paper IV a large group of mainly indolent CLL cases from a population based cohort was studied again showing an association between TL and prognosis, especially in “good” prognosis cases as defined by other biomarkers. Multivariate analysis indicated a strong connection between IGHV mutation status, lipoprotein lipase (LPL) expression and TL. A comparison of TL in diagnostic and follow up samples demonstrated a significant correlation, and also in the follow samples TL constituted a significant biomarker for survival.
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Valero, Mayor Cristina. "Capacidad pronóstica de los parámetros hematológicos en sangre periférica pre-tratamiento en los carcinomas escamosos de cabeza y cuello." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/662610.
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Introducción. Múltiples estudios vinculan la carcinogénesis y la inflamación en ambas direcciones. Por un lado, la inflamación crónica promueve el desarrollo de tumores, y por otro lado, la mayoría de los tumores muestran un infiltrado de células relacionadas con la respuesta inflamatoria que estimula la progresión tumoral. Además, el fracaso del sistema inmune en controlar y erradicar las células tumorales podría ser en parte responsable de la progresión tumoral. El grado de inflamación sistémica se correlaciona con el resultado oncológico en algunos modelos tumorales. Estudios realizados en diferentes tumores sólidos han asociado una disminución en el control de la enfermedad y la supervivencia con el aumento de los recuentos circulantes de neutrófilos y monocitos, la disminución de linfocitos, y una elevación del ratio entre neutrófilos y linfocitos (NLR). Objetivos. El objetivo del presente estudio es valorar la capacidad pronóstica de los recuentos de neutrófilos, monocitos, linfocitos y del NLR en sangre periférica pre-tratamiento en una gran serie de pacientes con carcinomas escamosos de cabeza y cuello (CECC) tratados consecutivamente en una sola institución. Además, se analizó por separado la cohorte de pacientes con tumores orofaríngeos según el estatus del Virus del Papiloma Humano (HPV). Material y Métodos. Los datos clínicos utilizados en este estudio se obtuvieron de forma retrospectiva de una base de datos que recoge prospectivamente datos epidemiológicos, de tratamiento y de seguimiento de los pacientes con CECC tratados en nuestra institución desde 1985. Se incluyeron 824 pacientes con un resultado anatomopatológico de carcinoma escamoso de cavidad oral, orofaringe, laringe o hipofaringe diagnosticado en nuestro centro entre enero de 2000 y diciembre de 2012 con un seguimiento mínimo de 2 años. Sólo incluimos los pacientes para los que obtuvimos los parámetros hematológicos dentro de las 4 semanas previas al inicio del tratamiento. Se analizó la supervivencia específica y la supervivencia libre de recidiva local, regional y a distancia de acuerdo con el recuento de neutrófilos, monocitos, linfocitos y el NLR. Resultados. Observamos una disminución ordenada en la supervivencia específica según aumentaba la categoría cuartil de neutrófilos, monocitos y NLR. En el caso de los linfocitos, sólo los pacientes en el cuartil inferior presentaron una supervivencia específica menor. Tras realizar un análisis de partición recursiva (RPA) considerando la supervivencia específica como variable dependiente, se obtuvieron cuatro nodos terminales en función de las cifras de neutrófilos y monocitos. La supervivencia específica a los 5 años para los pacientes del primer nodo (Neutrófilos <4.80x109/L – Monocitos <0.52x109/L) fue del 83.9%, para los pacientes del segundo nodo (Neutrófilos <4.80x109/L – Monocitos >0.52x109/L) fue del 73.1%, para los pacientes del tercer nodo (Neutrófilos entre 4.80-7.99x109/L) fue del 61.4%, y para los pacientes del cuarto nodo (Neutrófilos >7.99x109/L) fue del 47.4%. Al analizar los pacientes con tumores de orofaringe según el estatus HPV, los pacientes con tumores HPV positivos contaron con niveles de neutrófilos y monocitos y con un NLR significativamente inferiores a los correspondientes a los pacientes con tumores HPV negativos. No se encontraron diferencias en cuanto al recuento de linfocitos. Conclusiones. Un recuento elevado de neutrófilos y de monocitos y un NLR elevado, analizados pre-tratamiento en sangre periférica, se relacionaron con un peor pronóstico en pacientes con CECC de forma independiente, tanto al analizar la supervivencia específica como al analizar la supervivencia libre de recidiva local, regional y a distancia. Los linfocitos no mostraron capacidad pronóstica. Consideramos que la capacidad pronóstica del NLR, dependió básicamente del recuento de neutrófilos. La clasificación de los pacientes según el recuento de neutrófilos y de monocitos podría ser considerada un biomarcador útil de supervivencia en pacientes con CECC.<br>Background. Multiple studies link carcinogenesis and inflammation in both ways. On one hand, chronic inflammation promotes tumor development, and on the other hand, most tumors show an infiltrate of cells related to the inflammatory response that stimulate tumor progression. Moreover, the failure of the immune system to control and eradicate tumor cells could be partly responsible for the tumor progression. The degree of systemic inflammation correlates with the oncologic outcome in some tumor models. Studies carried out in different solid tumors have associated a decrease in disease control and survival with the increase of the circulating counts of neutrophils and monocytes, the decrease of lymphocytes, and an elevated ratio between neutrophils and lymphocytes (NLR). Objectives. The objective of the present study is to assess the prognostic capacity of the pre-treatment count of neutrophils, monocytes, lymphocytes and NLR in peripheral blood in a large series of patients with squamous cell carcinomas of the head and neck (HNSCC) treated consecutively in a single institution. In addition, the cohort of patients with oropharyngeal tumors was analyzed separately according to the status of the Human Papillomavirus (HPV). Materials and Methods. The clinical data used in this study were obtained retrospectively from a database that prospectively collects epidemiological, treatment and follow-up data of patients with HNSCC treated in our institution from 1985. We included 824 patients with an anatomopathological result of squamous cell carcinoma of the oral cavity, oropharynx, larynx or hypopharynx diagnosed in our center between January 2000 and December 2012 with a minimum follow-up of 2 years. We only included patients for whom we obtained the hematological parameters within 4 weeks prior to the start of treatment. The disease-specific survival and the local, regional and distant disease-free survival were analyzed according to the count of neutrophils, monocytes, lymphocytes and NLR. Results. We observed an ordered decrease in disease-specific survival as the quartile category of neutrophils, monocytes, and NLR increased. In the case of lymphocytes, only patients in the lowest quartile showed a poorer disease-specific survival. Considering the disease-specific survival as the dependent variable, a recursive partitioning analysis (RPA) classified the patients according to the neutrophil and monocyte counts. The 5-year disease-specific survival for the first node (Neutrophils <4.80x109/L - Monocytes <0.52x109/L) was 83.9%, for the second node (Neutrophils <4.80x109/L – Monocytes >0.52x109/L) it was 73.1%, for the third node (Neutrophils between 4.80-7.99x109/L) it was 61.4%, and for the fourth node (Neutrophils >7.99x109/L) it was 47.4%. When analyzing patients with oropharyngeal tumors according to HPV status, patients with HPV positive tumors had significantly lower neutrophil and monocyte counts and NLR than patients with HPV negative tumors. No differences in lymphocyte counts were found. Conclusions. A high pre-treatment count of neutrophils and monocytes and an elevated NLR, analyzed in peripheral blood, were independently associated with a worse prognosis in patients with HNSCC when analyzing the disease-specific survival and the local, regional and distant disease-free survival. The lymphocytes did not show prognostic capacity. We considered that the prognostic capacity of the NLR, basically depended on the neutrophil count. A classification of the patients according to neutrophil and monocyte counts could be considered a useful biomarker of survival in patients with HNSCC.
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Bedin, Valcinir. "Parametros de textura da cromatina como fator prognostico em carcinoma basocelular." [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310248.
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Orientador : Konradin Metze<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-03T23:37:03Z (GMT). No. of bitstreams: 1
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Previous issue date: 2004<br>Resumo: Vários estudos sobre os aspectos histológicos do carcinoma basocelular (CBC) foram realizados tentando correlacioná-Ios à agressividade loc~ porém são técnicas trabalhosas, de dificil execução e custosas. O presente trabalho teve como objetivo estabelecer diferenças entre a textura nuclear de tumores recidivantes (CBCR) e não recidivantes (CBCNR). Para tanto utilizamos um programa de computador desenvolvido pelo Instituto de Computação da Unicamp, com a assessoria do Departamento de Anatomia Patológica da mesma Universidade, para correlacionar esses achados ao comportamento biológico do tumor. Foram feitos, em 98 casos de carcinoma basocelular com acompanhamento mínimo de 5 anos, a avaliação da textura de cromatina do núcleo (no mínimo 100 por caso) através da transformada de Fourier, e a sua correlação com recidiva. Numa análise multivariada cox testamos relevância prognóstica de variáveis derivadas da transformada de Fourier junto com fatores preditivos conhecidos tais como tipo histológico e distância a margem cirúrgica. Obtivemos um modelo prognóstico onde variáveis derivadas da tranformada de Fourier entraram como fatores prognósticos independentes além dos fatores prognósticos já conhecidos. Portanto a análise computadorizada da cromatina em lâminas histológicas de rotina de ca basocelulares permite diferenciar diferentes graus de agressividade independentemente do grau histológico ou da distância até a margem cirúrgica .0 resultado nos mostrou que, através da utilização de um programa de computador de fácil utilização podemos acrescentar mais um instrumento ao arsenal disponível ao patologista<br>Abstract: Basal cell carcinomas (BCCs) usually follow a rather benign clinical course. A part of them however recurs after treatment causing a local tissue destruction. Therefore, morphological parameters that could help to distinguish between recurrent and non recurrent BCCs would be interesting. The aim of our study was to investigate whether morphometric variables of the nuclei in routinely stained histological sections and the chromatin texture could be helpful to identify patients with high risk for recurrence. We used a computer program , special developed by the Computer lnstitute of the UNICAMP (State University of Campinas-SP-Brazil) in association of the Pathology Department of the same university. We studied 98 BCC cases (52 non recurrent and 46 recurrent) with at least 60 months follow-up. In all cases we performed FFT (Fast Fourier Transform) in,-at least, 100 nuclei of each case. Then we correlated the FFT results with others predictive factors as histological types and surgical margin distance. We obtained a prognosis model where the Fast Fourier Transform results play an independent role besides the already known predictive factors. As a result we can assure that the computerized chromatin analysis performed in histological routine slides is able to di:fferentiatedi:fferentaggressiveness degrees in BCCs independent from the histological type or from the surgical margin distance. Our aim is to show that we can use a friendly user computer program as a novel instrument to the pathologist arsenal<br>Mestrado<br>Anatomia Patologica<br>Mestre em Ciências Médicas
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Trick, Daniela Carmen. "Prognostisch bedeutsame histomorphometrische Parameter in Sentinel-node-Metastasen beim malignen Melanom." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969593511.
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Bordonaro, Giancarlo Giuseppe. "Nonlinear System Identification of Physical Parameters for Damage Prognosis and Localization in Structures." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/30019.
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The understanding of how structural components endure loads, in particular variable loads, is that these components gradually, over some period of time depending on the nature of the loading and the material, develop a microcrack. After some additional time and loading, the microcrack grows to a size that might be detected. Beyond that point, the microcrack propagates in a manner that can be reliably predicted by computer analysis codes. Consequently, one can define different stages for the life of a structural component. These are: 1) the period prior to the formation of a microcrack, 2) the period of microcrack growth, and finally 3) the period of crack growth. To date, structural health monitoring approaches that seek to detect cracks offer no insight into the extent of deterioration occurring in the initial stage that is a precursor to the formation of the microcrack or its growth. However, an approach that would facilitate monitoring the extent of the deterioration that takes place during this stage promises to improve life prediction capabilities of structural components.
The challenge, thus, is to develop quantitative assessment of damage accumulation from the earliest stages of the fatigue process and to provide a structure's signature that is dependent of the damage stage. One such signature is the structure's response to forced excitation. The realization of such a goal would help in advancing structural health monitoring procedures using interrogative system identification techniques and determine sensitivities of physical parameters to damage. Additionally, vibration-based spectral quantities are related to physical properties of the structure under test.
In this thesis, nonlinear response to parametric excitation is exploited for nonlinear system identification of metallic and composite beam-mass systems before damage initiation through intermediate states of damage progression to failure. Parametric identification procedure combines linear and higher order spectral analysis of vibration measurements and perturbation techniques for the derivation of the approximate solution of the system nonlinear governing differential equation. The possibility of using optical Fiber Bragg Grating sensors technology for damage localization is also assessed. Spectral moments and quantities obtained from fiber optic strain measurements are evaluated near and away from cracks to assess the relation between these moments and cracks.
Variations in parameters representing natural frequency, damping and effective nonlinearities for different levels of progressive damage in a beam-mass system have been determined. Their percentage variations have been quantified to establish their sensitivities to damage initiation. The results show that damping and effective nonlinearity parameters are more sensitive to damage conditions than the natural frequency of the first mode. Crack localization is assessed by means of optical fiber technology for a composite beam-mass system. The results show that noise levels in fiber optic signals are high in comparison to strain gage signals. Of particular interest, however, is the observation that the nonlinear response is more pronounced near the cracks than away from them.<br>Ph. D.
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Eibl, Susanne A. "Zusammenhang zwischen Blutgruppe bzw. Rhesusfaktor und prognostisch wichtigen Parametern bei urologischen Tumoren." kostenfrei, 2008. http://mediatum2.ub.tum.de/doc/648861/648861.pdf.
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Spataru, Mihai. "Battery aging diagnosis and prognosis for Hybrid Electrical Vehicles Applications." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366364019.
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Santos, Inês Isabel Pacheco dos. "Associação entre parâmetros eritrocitários e prognóstico de hemangiossarcoma esplénico em cão." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2018. http://hdl.handle.net/10400.5/15893.
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Dissertação de Mestrado Integrado em Medicina Veterinária<br>O hemangiossarcoma é o tumor esplénico mais frequente em cães, na maioria dos quais se observa uma anemia. Se por um lado, a arquitetura vascular tumoral alterada gera uma lise eritrocitária, por outro, a sua natureza endotelial, a presença de cavidades preenchidas por sangue e a sua caraterística friabilidade, justificam a facilidade com que se verifica rutura neoplásica, dando origem a um quadro de hemorragia interna. De fato, a apresentação clínica mais frequente de um animal com hemangiossarcoma esplénico traduz-se por um quadro de hemoperitoneu. De referir que apesar de a coexistência de uma lesão esplénica e de hemoperitoneu constituir uma forte suspeita de hemangiossarcoma esplénico, apenas a análise histopatológica permitirá o seu diagnóstico definitivo.
No momento em que é detetada uma lesão no baço, associada ou não a rutura, o médico veterinário terá que lidar com as questões habitualmente colocadas pelos proprietários dos animais acerca do prognóstico e da sobrevivência expectável para o quadro clínico em questão (consoante a ocorrência de rutura esplénica ou não), bem como acerca das várias opções terapêuticas.
Deste modo, no presente trabalho pretendeu-se avaliar a associação entre os parâmetros eritrocitários indicadores de anemia (hematócrito, concentração de hemoglobina e contagem de eritrócitos), e o prognóstico de cães com hemangiossarcoma esplénico. Nesse sentido, foi realizada uma análise de sobrevivência para os grupos estabelecidos por valores limite/cut-off de 29.2%, 3.78x106/μl, e 8.97 g/dl para o hematócrito, contagem de eritrócitos e concentração de hemoglobina, respetivamente, e entre os quais se concluiu existir uma diferença significativa. Também foi efetuada uma análise de sobrevivência tendo em conta a presença inicial de rutura ou não, e de acordo com o tratamento efetuado (esplenectomia ou esplenectomia associada a posterior quimioterapia). Para o grupo de cães com rutura esplénica e submetidos apenas a esplenectomia, foi obtida uma menor mediana de sobrevivência.
Assim, e apesar das limitações do estudo, os resultados obtidos podem ser de utilidade para o clínico no estabelecimento de um prognóstico e da terapêutica a aplicar em casos de hemangiossarcoma esplénico.<br>ABSTRACT - ASSOCIATION BETWEEN ERYTHROCYTE PARAMETERS AND PROGNOSIS OF SPLENIC HEMANGIOSARCOMA IN DOG - Hemangiosarcoma is the most common splenic tumor in dogs, most of which are anemic. If, on the one hand, the altered tumor vascular architecture generates an erythrocyte lysis, on the other hand, its endothelial nature, the presence of blood filled cavities and its characteristic friability, justify the ease with which there is neoplastic rupture, giving rise to an internal hemorrhage. In fact, the most frequent clinical presentation of an animal with splenic hemangiosarcoma translates into a hemoperitoneum. It should be noted that although the coexistence of a splenic lesion and hemoperitoneum constitutes a strong suspicion of splenic hemangiosarcoma, only the histopathological analysis will allow its definitive diagnosis.
At the time a spleen lesion is detected, whether or not there is a rupture, the veterinarian will have to deal with the issues usually posed by the owners of the animals about the prognosis and the expected survival for the clinical picture in question (depending on the occurrence of splenic rupture or not), as well as the various therapeutic options.
The aim of this study was to evaluate the association between erythrocyte parameters indicative of anemia (hematocrit, hemoglobin concentration and erythrocyte count), and the prognosis of dogs with splenic hemangiosarcoma. In that sense, a survival analysis was performed for the groups established by limit/cut-off values of 29.2%, 3.78x106/μl, and 8.97 g/dl for the hematocrit, erythrocyte count and hemoglobin concentration, respectively, and between which it was concluded that there was a significant difference. A survival analysis was also performed considering the initial presence of rupture or not, and according to the treatment performed (splenectomy or splenectomy associated with subsequent chemotherapy). For the group of dogs with splenic rupture and only submitted to splenectomy, a lower median survival was obtained.
Thus, despite the limitations of the study, the results obtained may be of use to the clinician in the establishment of a prognosis and the therapy to be applied in cases of splenic hemangiosarcoma.<br>N/A
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Eigentler, Thomas Kurt. "Nierentransplantation Analyse prognostisch relevanter Parameter unter besonderer Berücksichtigung plasmazellreicher Abstossungsprozesse ; Morphologische und molekularbiologische Untersuchungen, sowie klinisch-morphologische Korrelationen /." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968949134.
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Tamssaouet, Ferhat. "Towards system-level prognostics : modeling, uncertainty propagation and system remaining useful life prediction." Thesis, Toulouse, INPT, 2020. http://www.theses.fr/2020INPT0079.
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Le pronostic est le processus de prédiction de la durée de vie résiduelle utile (RUL) des composants, sous-systèmes ou systèmes. Cependant, jusqu'à présent, le pronostic a souvent été abordé au niveau composant sans tenir compte des interactions entre les composants et l'impact de l'environnement, ce qui peut conduire à une mauvaise prédiction du temps de défaillance dans des systèmes complexes. Dans ce travail, une approche de pronostic au niveau du système est proposée. Cette approche est basée sur un nouveau cadre de modélisation : le modèle d'inopérabilité entrée-sortie (IIM), qui permet de prendre en compte les interactions entre les composants et les effets du profil de mission et peut être appliqué pour des systèmes hétérogènes. Ensuite, une nouvelle méthodologie en ligne pour l'estimation des paramètres (basée sur l'algorithme de la descente du gradient) et la prédiction du RUL au niveau système (SRUL) en utilisant les filtres particulaires (PF), a été proposée. En détail, l'état de santé des composants du système est estimé et prédit d'une manière probabiliste en utilisant les PF. En cas de divergence consécutive entre les estimations a priori et a posteriori de l'état de santé du système, la méthode d'estimation proposée est utilisée pour corriger et adapter les paramètres de l'IIM. Finalement, la méthodologie développée, a été appliquée sur un système industriel réaliste : le Tennessee Eastman Process, et a permis une prédiction du SRUL dans un temps de calcul raisonnable<br>Prognostics is the process of predicting the remaining useful life (RUL) of components, subsystems, or systems. However, until now, the prognostics has often been approached from a component view without considering interactions between components and effects of the environment, leading to a misprediction of the complex systems failure time. In this work, a prognostics approach to system-level is proposed. This approach is based on a new modeling framework: the inoperability input-output model (IIM), which allows tackling the issue related to the interactions between components and the mission profile effects and can be applied for heterogeneous systems. Then, a new methodology for online joint system RUL (SRUL) prediction and model parameter estimation is developed based on particle filtering (PF) and gradient descent (GD). In detail, the state of health of system components is estimated and predicted in a probabilistic manner using PF. In the case of consecutive discrepancy between the prior and posterior estimates of the system health state, the proposed estimation method is used to correct and to adapt the IIM parameters. Finally, the developed methodology is verified on a realistic industrial system: The Tennessee Eastman Process. The obtained results highlighted its effectiveness in predicting the SRUL in reasonable computing time
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Milandri, Agnese <1985>. "Alterazioni strutturali e funzionali nelle diverse eziologie di amiloidosi cardiaca: analisi dei parametri ecocardiografici ed emodinamici invasivi e loro ruolo prognostico." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amsdottorato.unibo.it/9690/1/Tesi%20%20-%20Agnese%20Milandri.pdf.
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Background e scopo:
Tradizionalmente la cardiomiopatia amiloidotica (CA) è stata considerata una cardiomiopatia restrittiva, ma studi recenti hanno evidenziato il ruolo anche della disfuzione sistolica nella sua fisiopatologia. In questo contesto recente, raramente è stato indagato il profilo emodinamico invasivo.
Lo scopo dello studio è stato quello di caratterizzare il profilo emodinamico, strutturale e funzionale della CA nelle tre principali eziologie (amiloidosi da catene leggere (AL), amiloidosi transtiretino-relata (ATTR) mutata (ATTRm) e ‘wild-type’ (ATTRwt)), valutare le differenze del profilo ecocardiografico ed emodinamico nelle fasi diverse di malattia ed esplorare il ruolo prognostico delle principali variabili cliniche e strumentali nella CA.
Metodi e risultati:
Abbiamo analizzato retrospettivamente i dati di 224 pazienti con CA (AL, n=93; ATTRm, n=66; ATTRwt, n=65). Rispetto all'ATTRwt, i pazienti con AL presentano un minor interessamento morfologico cardiaco, ma dati emodinamici paragonabili, caratterizzati da elevate pressioni di riempimento biventricolari e riduzione della gittata sistolica. L’ATTRm, nonostante il profilo ecocardiografico analogo all’ATTRwt, mostra un quadro emodinamico migliore.
Gli indici di funzione diastolica e sistolica longitudinale del ventricolo sinistro (Vsn) sono alterati fin dagli stadi iniziali della malattia, mentre la frazione di eiezione (FEVsn) rimane preservata nella maggior parte dei pazienti, anche nelle fasi avanzate (FEVsn 50 [37-60]%; FEVsn <40% nel 28% dei pazienti NYHA III / IV). All'analisi multivariata, età, NYHA III/I, eziologia AL, frazione di contrazione miocardica (MCF), indice cardiaco (CI) e pressione atriale destra (RAP) sono indipendentemente associati a eventi clinici avversi.
Conclusioni
Questo studio conferma la complessa fisiopatologia della CA, in cui la disfunzione diastolica è accompagnata da una funzione sistolica longitudinale anormale sin dalle fasi iniziali della malattia. L'AL e l'ATTRwt, nonostante diversi gradi di alterazioni morfologiche, hanno un profilo emodinamico simile; l'ATTRm, invece, presenta un quadro emodinamico migliore. Tra i parametri strumentali, MCF, CI e RAP emergono come predittori significativi di eventi avversi.<br>Background and aim
Traditionally, amyloidotic cardiomyopathy (CA) has been considered a restrictive cardiomyopathy, but recent studies have highlighted the greater complexity of its pathophysiology, in which even the systolic dysfunction plays an important role. In this recent context, the invasive hemodynamic profile has rarely been investigated.
Therefore, we sought to characterize the hemodynamic, structural and functional profiles of CA in the three main etiologies (light chain amyloidosis (AL), mutant transthyretin-related amyloidosis (ATTRm) and 'wild-type' ATTR (ATTRwt)), to evaluate their differences between various disease stages and to explore the prognostic role of the main clinical and instrumental variables in CA.
Methods and results
We retrospectively analyzed data of 224 patients with CA (AL, n=93; ATTRm, n=66; ATTRwt, n=65). Compared with ATTRwt, AL patients have a milder cardiac morphological involvement, but comparable hemodynamic data, characterized by increased biventricular filling pressures and reduced systolic stroke volume. ATTRm shows a better hemodynamic profile than ATTRwt, despite similar echocardiographic data.
LV diastolic and longitudinal systolic function indices (S wave at Tissue Doppler Imaging and longitudinal strain) are abnormal from the initial stage of the disease, while LV ejection fraction remains preserved in most patients, even in the advanced stages (FE 50 [37-60] %; FE < 40% in 28% of NYHA III/IV patients). At multivariable analysis, age, NYHA III/IV, AL etiology, myocardial contraction fraction (MCF), cardiac index (CI) and right atrial pressure (RAP) at catheterization are independently associated with adverse clinical events.
Conclusions
This study confirms the complex pathophysiology of CA, in which the diastolic dysfunction is accompanied by abnormal longitudinal systolic function from the initial disease stages. AL and ATTRwt, despite different degrees of morphological alterations, have a similar hemodynamic profile; ATTRm, instead, has more favorable hemodynamic parameters. Among the instrumental parameters, MCF, CI and RAP emerged as significant predictors of adverse events.
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Maja, Stefanović. "Prediktivna vrednost ehokardiografskih parametara funkcije desne komore za neželjeni ishod kod bolesnika sa hroničnom srčanom slabošću." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2018. https://www.cris.uns.ac.rs/record.jsf?recordId=107376&source=NDLTD&language=en.
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Cilj: Svrha ovog istraživanja je da se odredi prediktivna vrednost pojedinačnih i kombinovanih ehokardiografskih parametara desne komore za pojavu jednogodišnjeg neželjenog ishoda kod bolesnika sa hroničnom srčanom slabošću i sniženom istisnom frakcijom leve komore. Metodologija: U studiju je uključeno 191 bolesnik koji su od juna 2016. do marta 2017. godine hospitalizovani na Klinici za kardiologiju Instituta za kardiovaskuarne bolesti Vojvodine sa simptomima i znacima srčane slabosti sa sniženom istisnom frakcijom leve komore. Svim bolesnicima je uzeta anamneza, urađen klinički pregled, laboratorijske analize i trans-torakalni ehokardiografski pregled. Pacijenti su nakon toga praćeni godinu dana u cilju registrovanja značajnih neželjenih kardijalnih događaja (kardijalne smrti, smrti zbog drugih - nekardijalnih uzroka, rehospitalizacije zbog akutizacije hronične srčane slabosti, infarkta srca, malignih ventrikularnih poremećaja ritma i šloga). Kod 111 pacijenata je registrovan neželjeni ishod tokom jednogodišnjeg praćenja. Rezultati i diskusija: Kod pacijenata u istraživanju, kao značajni prediktori neželjenog ishoda unutar godinu dana, izdvojili su se sledeći eho-parametri desne komore: morfološki parametar - RV1 (granična vrednost 42 mm); parametar sistolne funkcije - TAs´(granična vrednost 10 cm/s) ; parametar opterećenja desne komore – RVSP (granična vrednost 40 mmHg) i kombinovani parametri - TAs´/RVSP granična vrednost 1,92 cm/s/mmHg) i TAPSE/RVSP (granična vrednost 0,28 mm/mmHg). Kombinovani ehokardiografski parametri, koji predstavljaju kombinaciju različitih osobine desne komore, imaju veći prediktivni značaj od pojedinačnih parametara. Među njima se izdvojio TAPSE/RVSP (parametri sistolne funkcije i opterećenja desne komore). Među svim posmatranim demografskim, kliničkim, laboratorijskim i ehokardiografskim parametrima obe komore parametar TAPSE/RVSP <0,28 mm/mmHg se opet izdvojio se kao statistički značajan i nezavisni prediktor neželjenog ishoda. Do sada u literaturi nisu opisani kombinovani parametri: TAs´/RVSP i TAs´x PVAcT (parametri sistolne funkcije i opterećenja desne komore). U mom istraživanju su visoko statistički značajano povezani sa pojavom neželjenog ishoda. U završnoj multi varijantnoj analizi (među demografskim, kliničkim, laboratorijskim i ehokardiografskim parametrima obe komore) izdvojilo se pet parametara koji su statistički značajni nezavisni prediktori neželjenog ishoda: života dob; atrijalna fibrilacija; nabrekle vene vrata; pretibijalni edemi i TAPSE/RVSP. Logistički model za procenu verovatnoće pojave velikih neželjenih kardijalnih događaja formiran je od pet parametara dobijenih multifaktorijalnom analizom. Na osnovu dobijenog modela određena je granična vrednost verovatnoće koja iznosi 0,61. Pacijenti sa vrednošću > 0,61 imaju visoku verovatnoću za pojavu neželjenog ishoda. Zaključak: Ehokardiografski parametri funkcije DK su značajni prediktori jednogodišnjeg neželjenog ishoda kod bolesnika sa hroničnom srčanom slabošću i sniženom istisnom frakcijom leve komore. Među njima se, kao superioran nezavisni prediktor jednogodišnjeg MACE izdvojio kombinovani parametar TAPSE/RVSP sa graničnom vrednošću od 0,28 mm/mmHg.<br>Objective: The aim of this study is to determine the predictive value of individual and combined echocardiographic parameters of the right ventricle for the occurrence of major adverse cardiac events in patients with chronic heart failure with reduced ejection fraction, during one-year follow-up. Methodology: The study included 191 patients, hospitalized with symptoms and signs of heart failure with reduced ejection fraction, from June 2016 to March 2017. All patients were subjected to clinical examination, laboratory analysis and transthoracic echocardiography. Patients were then followed up for one year in order to detect major adverse cardiac events (cardiac deaths, deaths due to other non-cardiac causes, rehospitalisation due to acute chronic heart failure, cardiac infarction, malignant ventricular disorders of rhythm and stroke). During a mean follow-up of 340±84 days, 111 patients reached the primary endpoint. Results and discussion: The following echo parameters of the right ventricle were selected as the important predictors of adverse cardiac events. Morphological parameter - RV1 (cut off threshold was 42 mm ); systolic function parameter - TAs (cut off value was 10 cm / s); right ventricular load parameter - RVSP (cut off value 40 mmHg) and combined parameters - TAs / RVSP (cut off value was 1.92 cm / s / mmHg) and TAPSE / RVSP (cut off value was 0.28 mm / mmHg). Combined echocardiographic parameters, which represent a combination of different properties of the right chamber, have a greater predictive significance than individual parameters. TAPSE / RVSP stands out among them (parameters of systolic function and right chamber load). Among all the observed demographic, clinical, laboratory and echocardiographic parameters of both chambers, the parameter TAPSE / RVSP <0.28 mm / mmHg is again stands out to a statistically significant and independent predictor of an adverse outcome. The combined parameters: TAs'/RVSP and TAs'x PVAcT (parameters of systolic function and right chamber load) were not described in the literature, so far. They were significantly related to the occurrence of an adverse cardiac outcome in my research. In the final multivariate analysis (among the demographic, clinical, laboratory and echocardiographic parameters of both chambers), five parameters were statistically significant independent predictors of an unwanted output: age; atrial fibrilation; swollen veins; pretibial edema and TAPSE / RVSP. A logistic model, for estimating the likelihood of the occurrence of major adverse cardiac events, was formed from five parameters obtained by multifactorial analysis. A probability cut off value of 0.61 was determined based on the obtained model. Conclusion:Echocardiographic parameters of the right ventricle are significant predictors of one-year major adverse cardiac events in patients with chronic heart failure with reduced ejection fraction. TAPSE / RVSP with a cut off value of 0.28 mm / mmHg was selected as the superior independent predictor of one-year adverse outcome.
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Van, Bellen Bonno. "Derivações arteriais abaixo do ligamento inguinal : o uso do doppler ultra-som para realização do teste da papaverina na avaliação per-operatoria e parametros prognosticos de perviedade." [s.n.], 1986. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313619.
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Tese (livre-docencia) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-07-16T10:54:33Z (GMT). No. of bitstreams: 1
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Previous issue date: 1986<br>Resumo: Não informado<br>Abstract: Not informed<br>Tese (livre-docencia) - Univer<br>Cirurgia<br>Livre Docente em Ciencias Medicas
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Mirela, Juković. "Prognostički značaj kliničkih i parametara kompjuterizovane tomografije kod pacijenata sa hroničnim subduralnim hematomom." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2014. https://www.cris.uns.ac.rs/record.jsf?recordId=88076&source=NDLTD&language=en.
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Uvod: Hronični subduralni hematom (HSDH) je učestala i nezanemarljiva traumatska/netraumatska intrakranijalna lezija, naročito kod pacijenata starije životne dobi. Simptomi pacijenata sa HSDH su raznovrsni i često pogrešno protumačeni i lečeni. Zbog navedenih činjenica, HSDH predstavlja veliki izazov u dijagnostici i terapiji. Različiti autori ističu značaj radioloških parametara tokom dijagnostike ovog oboljenja i povezanost sa kliničkom slikom I neurološkim statusom pacijenta, pa je ovo istraživanje bilo usmereno u preciznoj evaluaciji pomenutih parametara, njihovoj prediktivnoj vrednosti i uticaju na prognozu ishoda lečenja. Cilj: Generalni cilj istraživanja je bio da se ispita učestalost pacijenata sa hroničnim subduralnim hematomom na teritoriji Vojvodine u periodu od tri godine; da se analizira starosna dob pacijenata, polna distribucija oboljenja, uticaj komorbiditeta ili faktora rizika na nastanak HSDH; prisustvo ili odsustvo traume koja je doprinela nastanku HSDH, vremenski interval od traume do pojave simpotoma ili znakova bolesti i da se omogući praćenje efekta terapije pacijenata sa ovim oboljenjem. Specifični ciljevi su obuhvatili: 1. Da se utvrde parametri kompjuterizovane tomografije koji imaju prediktivni značaj u pozitivnom ishodu lečenja pacijenata sa hroničnim subduralnim hematomom. 2. Da se utvrde klinički parametri koji imaju prediktivni značaj u pozitivnom ishodu lečenja pacijenata sa hroničnim subduralnim hematomom. 3. Da se dobije model sa najvećom specifičnošću i senzitivnošću za predikciju ishoda lečenja, kombinacijom kliničkih i parametrara kompjuterizovane tomografije kod pacijenata sa hroničnim subduralnim hematomom. Materijal i metode: Istraživanje je obavljeno kao prospektivna trogodišnja studija u periodu od aprila 2010. do aprila 2013. godine u Kliničkom Centru Vojvodine- Centru za radiologiju i Klinici za neurohirurgiju i obuvatila je 83 pacijenata sa dijagnozom hroničnog subduralnog hematoma. Svi ispitanici su dijagnostikovani upotrebom kompjuterizovane tomografije glave (CT) i lečeni na Klinici za neurohirurgiju KCV. Izvori podataka su celokupna medicinska dokumentacija svakog pacijenta od perioda prve hospitalizacije do njihovog otpusta, a uključuje i podatke vezane za subjektivni osećaj o zdravstvenom stanju koje su pacijenti usmeno izneli šest meseci nakon hospitalnog otpusta. Rezultati: Rezultati istraživanja pokazuju da je Glasgow Coma Scala (GCS) tj. nivo svesti pacijenta na hospitalnom prijemu jedini parametar sa visokom prediktivnom vrednošću za klinički ishod lečenja pacijenata sa HSDH procenjen preko Glasgow Outcome Scale (GOS). Preostali radiološki i klinički parametri (širina hematoma, pomeraj mediosagitalne linije, denzitet hematoma, starost pacijenta) nemaju visoku prediktivnu vrednost za klinički ishod pacijenata sa hroničnim subduralnim hematomom. Zaključak: Na osnovu grupe analiziranih pacijenata sa HSDH nije bilo moguće napraviti optimalan model za predikciju ishoda lečenja kombinujući radiološke i kliničke parametre. Pojedinačno posmatrani radiološki parametri nisu imali visoku prediktivnu vrednost za ishod lečenja pacijenata sa HSDH. Izolovan klinički parametar- GCS- je jedini visoko prediktivni faktor za ishod lečenja pacijenata sa HSDH. Kombinacija kliničkih i radioloških parametara daje visoku vrednost predviđanja kliničkog ishoda lečenja, ali samo zahvaljujući izrazito visokoj prediktivnoj vrednosti GCS. Iz svega navedenog, kompjuterizovana tomografija (CT) ima veliki značaj u ranoj dijagnostici i praćenju terapije pacijenata sa HSDH, ali CT parametri ponaosob nemaju značaj u predviđanju ishoda lečenja.<br>Introduction: Chronic subdural hematoma (CSDH) is common traumatic/no traumatic intracranial lesion, especially in older patients. Symptomatology of this disease is variable and often is misdiagnosed and treated with specially challenges in diagnostic and therapy. Different authors pointed on importance of radiological parameters during diagnostic of this disease and connections with clinic and neurological status in patients with chronic subdural hematoma (CSDH), so this thesis was directed to evaluate radiological and clinical parameters of CSDHs and to show their predictive values and their significance on patient’s outcome. Aim: General aim of this thesis was to examine frequency of patients with chronic subdural hematoma in Vojvodina, during the period of three years, to analyze the age of population with CSDHs, the gender distribution, an impact of comorbidity or risk factors for patients with CSDHs, the presence or absence of trauma which has contributed to CSDH, to determine time interval from trauma to appearance of symptoms and signs of disease, monitoring the effect of therapy. Specific aims were: 1. To determine clinical parameters with a positive predictive significance on patients outcome 2. To determine radiological parameters with a positive predictive significance on patients outcome 3. To determine optimal prognostic model with high specificity and sensitivity, using combination of radiological and clinical parameters for positive prediction outcome. Material and methods: The study was performed as three-year prospective study from April 2010 to April 2013 in Clinical Centre of Vojvodina, Centre for Radiology and Clinic of Neurosurgery and includes 83 patients with chronic subdural hematoma. All patients were diagnosed using computed tomography of the brain (CT scan) and all were treated in Clinic of Neurosurgery (KCV). Data sources included the medical records of each patient from the time of first hospitalization to period of their discharge and included data related to the subjective feeling of the health that patients verbally present six months after hospital discharge. Results: The results showed that the Glasgow Coma Scale (GCS) - a level of consciousness of the patient on the hospital admission was the only parameter with a high predictive value for clinical outcome of patients with CSDH assessed through Glasgow Outcome Scale (GOS). Other evaluated radiological and clinical parameters (width of the CSDH, mediosagital line displacement, a density of the CSDH, the age of the patient) did not have high predictive values for the clinical outcome in patients with chronic subdural hematoma. Conclusion: Based on the analyzed group of patients with CSDH it was not possible to make optimal predictive model for outcome by combining radiological and clinical parameters. Radiographic parameters did not have high predictive values for treatment outcome in patients with CSDH. Glasgow Coma Scale (GCS) is the only highly predictive factor for treatment outcome in patients with CSDH. The combination of clinical and radiological parameters gives high predictive value for clinical outcome, but only because of extremely high predictive value of GCS. Therefore, computed tomography (CT) is of great importance in early diagnosis and therapy monitoring of patients with CSDH, but CT parameters did not have the high predictive values for the patient’s clinical outcome.
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GAZZANELLI, SERGIO. "CONDOTTA ANESTESIOLOGICA E SIGNIFICATO PROGNOSTICO DELLE VARIAZIONI DEI PARAMETRI VITALI E DEGLI INDICATORI BIOCHIMICI DI LISI CELLULARE IN CORSO DI ANESTESIA PER CHIRURGIA CITORIDUTTIVA CON CHEMIOIPERTERMIA INTRAPERITONEALE PER NEOPLASIA LOCALMENTE AVANZATA." Doctoral thesis, La Sapienza, 2006. http://hdl.handle.net/11573/917477.
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Varescon, Jean-Pascal Marie Dieudonné [Verfasser], Thomas O. F. [Akademischer Betreuer] Wagner, Thomas O. F. [Gutachter] Wagner, and Stefan [Gutachter] Zielen. "Comparison of surrogate parameters of prognosis (BMI, FEV1 and need of intravenous antibiotic therapy) between CF-patients with and without P. aeruginosa in Frankfurt and Moscow from 1990 to 2015 / Jean-Pascal Marie Dieudonné Varescon ; Gutachter: Thomas O. F. Wagner, Stefan Zielen ; Betreuer: Thomas O. F. Wagner." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2021. http://d-nb.info/1239143818/34.
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Farfan-Ramos, Luis. "Real-time Fault Diagnosis of Automotive Electrical Power Generation and Storage System." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1303129393.
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Shahin, Kamrul. "Modèle graphique probabiliste appliqué au diagnostic de l'état de santé des systèmes, au pronostic et à l'estimation de la durée de vie résiduelle." Electronic Thesis or Diss., Université de Lorraine, 2020. http://www.theses.fr/2020LORR0129.
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Cette thèse contribue au développement des recherches dans le domaine du Pronostic et Health Management : gestion de l’état de santé des systèmes complexes. Dans un contexte de management opérationnel et de sûreté de fonctionnement des systèmes, nous proposons d’étudier comment la modélisation par un Modèle Graphique Probabiliste Dynamique (MGPD) permet le diagnostic de l’état de santé courant d’un système, le pronostic de cet état et de l’évolution des dégradations, ainsi que l’estimation de sa durée de vie résiduelle en fonction de ses conditions opérationnelles. La dégradation des composants est en général inconnue et nécessite un arrêt du système pour être observée. Cependant, cela est difficile, voire impossible, durant l’exploitation du système. Néanmoins, un ensemble de grandeurs observables sur le système ou le composant peut caractériser le niveau de dégradation et faciliter l’estimation de la durée de vie résiduelle du composant et du système. Les MGPD offrent une approche adaptée à la modélisation de l’évolution de l’état de santé des systèmes et des composants. Nous étendons la modélisation classique des modèles de la famille des HMM vers les IOHMM pour permettre une propagation temporelle de l’incertitude afin de résoudre le problème de pronostic de l’état de santé et de l’estimation de la durée de vie résiduelle. Cette recherche comprend l’extension des algorithmes d’apprentissage et d’inférence appliqués aussi bien dans le cas d’un composant que pour un système structuré. Cette thèse a pour but de contribuer à lever les verrous scientifiques suivants : - Considérer l'état de santé du système par un modèle stochastique et apprendre les paramètres du modèle à partir des mesures disponibles sur le système. - Établir un diagnostic de l’état de santé du système et le pronostic de son évolution en intégrant plusieurs conditions opérationnelles. - Estimer la durée de vie résiduelle des composants et des systèmes structurés (série, parallèle) à partir de ses composants. L’enjeu est majeur, car le pronostic de la dégradation des composants du système permet de définir des stratégies soit de pilotage soit de maintenance par rapport à la durée de vie résiduelle du système. Cela permet la réduction de la probabilité d’occurrence d’un arrêt pour cause de dysfonctionnement du système, soit en ajustant la vitesse de dégradation pour s’accorder à un plan de maintenance préventif, soit en planifiant les interventions de maintenance de manière proactive<br>This thesis contributes to prognosis and health management for assessing health condition of complex systems. In the context of operational management and operational safety of systems, we propose to investigate how Dynamic Probabilistic Graphical Modelling (DPGM) can be used to diagnose the current health state of systems, prognostic the future health state, and the evolution of degradation, as well as estimate its remaining useful life based on its operating conditions. System degradation is generally unknown and requires shutting down the system to be observed. However, this is difficult or even impossible during system operation. Though, a set of observable quantities on a system or component can characterise the level of degradation and help to estimate the remaining useful life of components and systems. The DPGM provides an approach suitable for modelling the evolution of the health state of systems and components. The aim of this thesis is to transpose and capitalize on the experience of these previous works in a prognostic context on the basis of a more efficient DPGM taking into account the available knowledge on the system. We extend the classical HMM family models to the IOHMM to allow the time propagation of uncertainty to address prognostic problems. This research includes the extension of learning and inference algorithms. Variants of the HMM model are proposed to incorporate the operating environment into the prognosis. The aim of this thesis is to contribute to solving the following scientific locks: - Considering the state of health whatever the complexity of the system by a stochastic model and learning the model parameters from the available measurements on the system. - Establish a diagnosis of the state of health of the system and the prognosis of its evolution by integrating several operational conditions. - Estimate the remaining useful life of components and structured systems with series and parallel components. This is a major challenge because the prognosis of the degradation of system components makes it possible to define strategies for either control or maintenance in relation to the residual life of the system. This allows the reduction of the probability of occurrence of a shutdown due to a system malfunction either by adjusting the degradation speed to fit in with a preventive maintenance plan or by proactively planning maintenance interventions
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Raymond, Wendy Ann. "Immunohistochemcial prognostic parameters in breast carcinoma / Wendy Ann Raymond." Thesis, 1990. http://hdl.handle.net/2440/38405.
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Rosado, Maria Margarida dos Santos. "Prognostic role of platelet parameters in ischemic stroke : systematic review and meta-analysis." Master's thesis, 2019. http://hdl.handle.net/10451/43278.
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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2019<br>Contextualização: Vários factores estão associados ao prognóstico de doentes com Acidente Vascular Cerebral (AVC) isquémico, nomeadamente a gravidade e subtipo de AVC, a idade, sexo e terapêutica realizada. Com base no papel das plaquetas na hemostase e na regulação das respostas inflamatórias, os parâmetros plaquetários, tais como a contagem de plaquetas (CP), volume plaquetário médio (VPM), plaquetócrito (PCT) e amplitude de distribuição das plaquetas (PDW), têm potencial como predictores de prognóstico. Contudo, os resultados de vários estudos sobre esta temática foram inconclusivos. Objectivos: Realizar uma revisão sistemática para avaliar o papel prognóstico dos parâmetros plaquetários em adultos com AVC isquémico. Métodos: Pesquisa de estudos potencialmente elegíveis na PubMed, ClinicalTrials.gov e Cochrane Library. Extracção de dados relevantes e meta-análise dos mesmos. Resultados: Incluíram-se 22 estudos na síntese qualitativa. A qualidade geral dos estudos foi baixa, com elevada heterogeneidade. O VPM foi avaliado em 14 estudos, a CP em sete e o rácio plaquetário (VPM/CP) em um. Seis estudos tinham dados adequados para a síntese quantitativa para avaliar a associação entre o VPM e prognóstico (Escala de Rankin modificada). A meta-análise incluiu 2201 doentes e demonstrou que níveis mais elevados de VPM na admissão estão associados a prognóstico desfavorável (OR (95% CI) = 1.47 (1.22-1.79)). A heterogeneidade foi substancial (I2=69.9%), mas diminuiu na análise de sub-grupos incluindo estudos com análise multivariada (OR = 2.11, 95% CI, 1.59-2.80; I2=26.1%). Apesar da síntese qualitativa sugerir que CP menores estão associadas a pior prognóstico, a síntese quantitativa não foi realizada por falta de dados. Conclusão: VPM mais alto na admissão está associado a pior prognóstico. É necessário realizar mais estudos para avaliar o valor de outros parâmetros plaquetários na predição de prognóstico e determinar como esta evidência pode ser transposta para a prática clínica.<br>Background: Several factors are associated with the prognosis of patients with ischemic stroke, including stroke severity and subtype, age, sex and treatment. Based on the platelets’ role in hemostasis and in regulation of inflammatory responses, platelet parameters, such as platelet count (PC), mean platelet volume (MPV), plateletcrit (PCT), and platelet volume distribution width (PDW), were suggested to be used as prognostic predictors. However, the results of several studies were not conclusive. Objectives: Evaluate the prognostic role of platelet parameters in adult patients with acute ischemic stroke through a systematic review. Methods: PubMed, ClinicalTrials.gov and Cochrane Library were searched for potential eligible literature. Relevant data was extracted and a systematic review and meta-analysis was conducted. Results: 22 studies were included for qualitative synthesis. Overall studies’ quality was very low, with large heterogeneity. MPV was evaluated in 14 studies, PC in seven, and platelet ratio (MPV/PC) in one. Six studies had suitable data for quantitative synthesis assessing the association between MPV and prognosis (modified Rankin scale). The meta-analysis included 2201 patients, and showed that higher levels of MPV at admission were associated with an unfavorable prognosis (pooled OR (95% CI) = 1.47 (1.22-1.79)). The heterogeneity was substantial (I2=69.9%), but decreased when only studies with multivariate analysis were analyzed (OR = 2.11, 95% CI, 1.59-2.80; I2=26.1%). Although the qualitative synthesis suggested that lower PC was associated with poor prognosis, quantitative synthesis was not carried out due to lack of data. Conclusion: Higher MPV at admission is associated with a poorer prognosis. More studies are required to assess the value of other platelet parameters in prognosis prediction, and to ascertain how this evidence could be translated into clinical practice.
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Coble, Jamie Baalis. "Merging data sources to predict remaining useful life an automated method to identify prognostic parameters /." 2010. http://trace.tennessee.edu/utk_graddiss/683.
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Chao, Chun-Chieh, and 趙君傑. "Prognostic Value of QT Parameters in Patients with Acute Hemorrhagic Stroke: A Prospective Evaluation with Respect to Mortality and Post-hospitalization Bed Confinement." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/m9bf24.
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碩士<br>國立陽明大學<br>急重症醫學研究所<br>97<br>Background: This prospective study was performed to evaluate the prognostic prediction value of QT parameters and clinical characteristics exhibited by patients with acute hemorrhagic stroke at the time of presenting to the emergency department (ED).
Methods: One hundred sixty-six patients admitted to the ED of the Taipei-Veterans General Hospital from January 2006 to October 2006 because of acute hemorrhagic stroke were enrolled. Glasgow Coma Scale (GCS) scores between 3 and 8 were taken to indicate severe neurological deficits. QT parameters (QT max, QT min, QT dispersion, QTc max, QTc min, QTc dispersion) and other pertinent clinical variables were determined on admission. Logistic regression model was applied to evaluate prognostic prediction values.
Results: Mortality was higher among stroke patients with low GCS scores (p <0.01). Leukocyte counts and systolic blood pressures were significantly higher among non-surviving patients (p = 0.04). No association was found between QT parameters and mortality (all p >0.05). Among survivors, post-hospitalization bed confinement was required for those significantly older (p = 0.01) and with higher QT max and QTc max values in multivariate analyses (p = 0.04 and p <0.01, respectively).
Conclusions: Low GCS scores, increased leukocyte counts, and elevated systolic blood pressures predict increased mortality for subjects with acute hemorrhagic stroke. Advanced age and prolongations in QTc and QT max at the time of stroke predicted poor functional recovery for these subjects.
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Chen, Yi-Chun, and 陳怡君. "Analysis of CDKN2 gene alteration in lung cancerpatients in Taiwan:Correlation with clinicopathological parameters, and prognosis." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/9s37mw.
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碩士<br>中山醫學院<br>毒理學研究所<br>88<br>Lung cancer is the leading and the second cause of cancer deaths among women and men in Taiwan, respectively. There is increasing evidence that alterations in tumor suppressor genes and oncogenes are common in many forms of human cancer including lung cancer. Recently, cyclin-dependent kinase N2 (CDKN2) gene has been identified as a tumor suppressor gene that is preferentially altered by homozygous deletions and promoter hypermethylation in many tumors including lung cancer. These CDKN2 gene alterations may result in its p16 protein loss expression. Therefore, the purpose of my thesis is to examine the frequency of CDKN2 gene alterations and frequency of loss p16 protein expression in lung cancer patients in Taiwan. To avoid the contamination of normal cells, the tumor component was manually microdissected from histological section. The dissected DNA was then analyzed by the comparative multiplex polymerase chain reaction（PCR）, microsatellite polymorphism and methylation-based PCR analysis. These analyses were used to investigate the frequencies of homozygous deletion, loss of heterozygosity, and hypermethylation of CDKN2 tumor suppressor gene, respectively. In addition, the altered expression of p16 protein was analyzed by immunohistochemistry assay. My thesis is designed to evaluate (1) whether the alterations of CDKN2 tumor suppressor gene is frequent in lung cancer patients in Taiwan, (2) whether the mechanisms involved in alteration of CDKN2 gene are homozygous deletion, loss of heterozygosity, and promoter hypermethylation, (3) whether the loss of p16 protein expression is frequent in lung cancer patients, and (4) whether the alterations of CDKN2 gene and p16 protein are associated with clinicopathological parameters and prognosis of lung cancer patients. Our data show that: (a) 48.7%lung cancer patients loss of p16 protein expression and had poor prognosis (P=0.059); (b) 52.9% loss of heterozygosity; (c) 58.3% CDKN2 gene promoter hypermethylation and correlated with p16 protein loss of expression (P=0.029); and (d) CDKN2 gene homozygous allele deletion only 2%. We indicated that p16 protein loss of expression and CDKN2 gene alteration involved in lung tumorigenesis in Taiwan, major on p16 protein expression, loss of heterozygosity, and CDKN2 gene promoter hypermethylation. The results of my thesis may be important to understand the molecular mechanism(s) involved in lung tumorigenesis in Taiwan.
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Eibl, Susanne A. [Verfasser]. "Zusammenhang zwischen Blutgruppe bzw. Rhesusfaktor und prognostisch wichtigen Parametern bei urologischen Tumoren / Susanne A. Eibl." 2008. http://d-nb.info/99207844X/34.
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Jenčo, Jaroslav. "Stanovení vybraných biochemických parametrů a jeich diagnostické a prognostické hodnoty u septických onemocnění." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-337333.
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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Jaroslav Jenčo Supervisor: prof. MUDr. Jaroslav Dršata, CSc. Consultant: Ing. Jana Netriová, PhD. Title of diploma thesis: Determination of biochemical parameters and their diagnostic and prognostic value in sepsis Sepsis is a relatively common complication that may be signed by the increased mortality of patients. It affects all ages, regardless of gender. Occurrence is more frequent in polymorbid and immunosuppressed patients. The most effective method to prevent the development of septic complications is quick and accurate diagnosis. In the period from 1.6.2012 to 01.4.2014, we observed 697 patients hospitalized due to the development of septic complications and we analyzed statistically tracked markers: presepsin, procalcitonin, C - reactive protein, interleukin - 6, lactate, D - dimer, fibrinogen and quantity of leukocytes to determine their predictive and diagnostic value. Largest correlation was observed between comparison of presepsin with procalcitonin and presepsin with C - reactive protein, which reflected rapidly changing status of patients. Moderate correlation was observed in lactate, interleukin - 6, D - dimer concentration and leukocyte count. Between the development...
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Trick, Daniela Carmen [Verfasser]. "Prognostisch bedeutsame histomorphometrische Parameter in Sentinel-node-Metastasen beim malignen Melanom / vorgelegt von Daniela Carmen Trick." 2003. http://d-nb.info/969593511/34.
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Huang, Chun-Ming, and 黃鈞民. "Pre-operative concurrent chemoradiotherapy for patients with locally advanced or low rectal cancer-The impact of clinical parameters and pathologic characteristics on prognosis." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/98583915519428798168.
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碩士<br>高雄醫學大學<br>醫學研究所<br>100<br>The incidence of colorectal cancer (CRC) in Taiwan has been rapidly increasing in the past few years, and CRC is the second most common cancer and also the third leading cause of cancer death in Taiwan. For locally advanced rectal cancer (T3-4 or N1-2), preoperative chemoradiotherapy (CCRT) has been demonstrated to achieve a lower local recurrence rate and good sphincter preservation rate. Several prospective and retrospective analyses suggest that pathological stage of disease after preoperative CCRT has a significant prognostic impact on disease-free and overall survival. In particular, the subgroup of patients who achieve a complete pathological response has a very low risk of local or distant recurrence. Traditionally, it is usually depends on TNM stage to determine whether patient receives preoperative CCRT or not. This proposal is aimed to discover clinical factors that can increase the power to predict the efficacy of preoperative CCRT.
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Eigentler, Thomas [Verfasser]. "Nierentransplantation : Analyse prognostisch relevanter Parameter unter besonderer Berücksichtigung plasmazellreicher Abstoßungsprozesse ; Morphologische und molekularbiologische Untersuchungen, sowie klinisch-morphologische Korrelationen / vorgelegt von Thomas Kurt Eigentler." 2003. http://d-nb.info/968949134/34.
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CARDI, ANTONIO. "VALUTAZIONE DI NUOVI FATTORI PROGNOSTICI E PARAMETRI DI VALUTAZIONE DELL'ATTIVITA' SESSUALE E DELLA CONTINENZA URINARIA IN PAZIENTI OPERATI DI PROSTATECTOMIA RADICALE NERVE SPARING CON TECNICA OPEN, LAPAROSCOPICA E ROBOTICA." Doctoral thesis, 2014. http://hdl.handle.net/11573/917405.
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differenze di risultati in termini di continenza, potenza e risultati oncologici, in pazienti sottoposti a prostatectomia radicale nerve sparing bilaterale, operati con tecnica open, laparoscopica e robotica.
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"Physical and biological parameters affecting the reaction of human tissues and tumours to ionizing radiation: a statistical and experimental study of the development of methods for determining therapeutic ratios, optimal dosage factors, and a theoretical prognosis in clinical radiation therapy." Thesis, 2015. http://hdl.handle.net/10539/16953.
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