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Journal articles on the topic 'Prognostic parameters'

Author: Grafiati
Published: 4 June 2025
Last updated: 8 July 2025

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1

Holmes, Paula. "Pertussis prognostic parameters." Pathology 51 (February 2019): S124—S125. http://dx.doi.org/10.1016/j.pathol.2018.12.358.

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2

Schiavone, D., A. Isgrò, F. Migliorini, et al. "Prognostic value of clinical parameters for renal cell carcinoma." Urologia Journal 64, no. 2 (1997): 156–64. http://dx.doi.org/10.1177/039156039706400202.

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– Clinical evaluation of patients with kidney tumours should provide several parameters with possible prognostic value, such as age, sex, incidental discovery, duration of symptoms, weight loss, fever, disease-free interval, performance status, elevated ESR, hypercalcemia, elevated gamma-enolase, local tumour extension, invasion of renal vein and inferior vena cava, lymphatic metastases, distant metastases, tumour dimension, multicentricity, bilaterality and growth velocity. Some of these factors correlate to prognosis in univariate statistical analysis; in multivariate analysis, however, tumour stage is the best prognostic factor, while the other parameters show less or no prognostic value. Besides tumour stage, parameters with an independent value are performance status, weight loss, elevated ESR. Using these prognostic factors, patients can be divided into groups with different prognosis and treatment.
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3

Mikniene, Zoja, Indre Mickeviciene, Elvina Apulskyte, and Donata Mikalauskienė. "PROGNOSTIC VALUE OF PHYSIOLOGICAL PARAMETERS IN EQUINE COLIC PATIENTS." 3i intellect idea innovation - интеллект идея инновация 2 (2023): 37–41. http://dx.doi.org/10.52269/22266070_2023_2_37.

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The article describes the results of a study of 46 heads of horses with colic syndrome at the veterinary clinic of the Lithuanian University of Medical Sciences in the period from 2016 to 2018. Upon arrival, anamnesis, condition of horses and duration of colic syndrome were recorded. During the clinical exami¬nation, 9 physiological parameters were recorded: temperature, heart rate, capillary filling time, mucosal color, respiratory rate, gastrointestinal noises, gastric reflux, digital pulse and volume of packed cells. All animals were divided into 2 groups: survivors and non-survivors. After that, the 9 physiological parameters described above were compared in two groups to determine their significant prognostic value for the survival of horses. Nine variables were used in the Cox proportional risk model. The odds ratio and the corresponding confidence interval were obtained. The paper shows the results of the survival rate of horses, taking into account the sexual trait. The causes of the appearance of colic syndrome are analyzed. The most important physiological parameters in relation to the appearance, course and completion of colic syndrome have been identified.
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4

Kusdjianto, Amanda Yuanita. "The Role of Critical Laboratory Parameters to Determine the Severity and Prognosis of COVID-19: Systematic Review." Cermin Dunia Kedokteran 49, no. 10 (2022): 585–88. http://dx.doi.org/10.55175/cdk.v49i10.311.

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Introduction: Few studies have addressed the diagnostic and prognostic value of abnormal laboratory findings in COVID-19 patients. Objective: To identify and assess published studies on the role of laboratory parameters to determine the severity of COVID-19 patients. Method: Systematic review of articles identified from NCBI, Pubmed, BMC, and Elsevier from 2020-2022. Results: Laboratory parameters: complete blood count, serum electrolyte, renal function, liver function, pancreatic enzymes, D-dimer, inflammatory cytokines, and C-reactive protein have a diagnostic and prognostic value in determining the severity of COVID-19. Conclusion: Laboratory parameters have functional prognostic value in determining COVID-19 severity. Pendahuluan: Beberapa penelitian telah membahas nilai diagnostik dan prognostik dari temuan laboratorium abnormal pada pasien COVID-19.Tujuan: Mengidentifikasi peranan parameter laboratorium dalam menentukan keparahan pasien COVID-19. Metode: Review sistematik atas artikel berasal dari NCBI, Pubmed, BMC, Elsevier tahun 2020-2022. Hasil: Parameter laboratorium darah lengkap, elektrolit serum, fungsi ginjal, hati, pankreas, D-dimer, sitokin inflamasi, dan C-reactive protein memiliki nilai diagnosis dan prognosis pasien COVID-19. Simpulan: Parameter laboratorium berperan dalam menentukan keparahan pasien COVID-19
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Bostofte, Erik. "Prognostic parameters in predicting pregnancy." Acta Obstetricia et Gynecologica Scandinavica 66, no. 7 (1987): 617–24. http://dx.doi.org/10.3109/00016348709022067.

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6

Preston, H. S., L. Moore, I. Toogood, J. Drew, and R. W. Byard. "Prognostic parameters in chlldhood rhaboomyosarcoma." Pathology 25 (1993): 1. http://dx.doi.org/10.1016/s0031-3025(16)35714-2.

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7

Hamza, Sate. "Prognostic parameters of malignant melanoma." Diagnostic Histopathology 16, no. 7 (2010): 330–36. http://dx.doi.org/10.1016/j.mpdhp.2010.03.015.

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8

Prat, Jaime. "Prognostic parameters of endometrial carcinoma." Human Pathology 35, no. 6 (2004): 649–62. http://dx.doi.org/10.1016/j.humpath.2004.02.007.

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9

Leong, Anthony S. Y., and Wendy A. Raymond. "Prognostic parameters in breast cancer." Pathology 21, no. 3 (1989): 169–75. http://dx.doi.org/10.3109/00313028909061053.

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10

Hofmann, H., W. Tuma, F. X. Heinz, and C. Kunz. "Prognostic parameters of hepatitis B." Serodiagnosis and Immunotherapy in Infectious Disease 2, no. 6 (1988): 453–59. http://dx.doi.org/10.1016/0888-0786(88)90010-8.

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11

Westergaard, L., F. Gjerris, and L. Klinken. "Prognostic parameters in benign astrocytomas." Acta Neurochirurgica 123, no. 1-2 (1993): 1–7. http://dx.doi.org/10.1007/bf01476278.

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12

Mink, Jan Niklas, Oybek Khalmurzaev, Alexey Pryalukhin, et al. "Evaluation of Prognostic Parameters to Identify Aggressive Penile Carcinomas." Cancers 15, no. 19 (2023): 4748. http://dx.doi.org/10.3390/cancers15194748.

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Background: Advanced penile carcinoma is characterized by poor prognosis. Most data on prognostic factors are based on small study cohorts, and even meta-analyses are limited in patient numbers. Therefore, there is still a lack of evidence for clinical decisions. In addition, the most recent TNM classification is questionable; in line with previous studies, we found that it has not improved prognosis estimation. Methods: We evaluated 297 patients from Germany, Russia, and Portugal. Tissue samples from 233 patients were re-analyzed by two experienced pathologists. HPV status, p16, and histopathological parameters were evaluated for all patients. Results: Advanced lymph node metastases (N2, N3) were highly significantly associated with reductions in metastasis-free (MFS), cancer-specific (CS), and overall survival (OS) rates (p = <0.001), while lymphovascular invasion was a significant parameter for reduced CS and OS (p = 0.005; p = 0.007). Concerning the primary tumor stage, a significant difference in MFS was found only between pT1b and pT1a (p = 0.017), whereas CS and OS did not significantly differ between T categories. In patients without lymph node metastasis at the time of primary diagnosis, lymphovascular invasion was a significant prognostic parameter for lower MFS (p = 0.032). Histological subtypes differed in prognosis, with the worst outcome in basaloid carcinomas, but without statistical significance. HPV status was not associated with prognosis, either in the total cohort or in the usual type alone. Conclusion: Lymphatic involvement has the highest impact on prognosis in penile cancer, whereas HPV status alone is not suitable as a prognostic parameter. The pT1b stage, which includes grading, as well as lymphovascular and perineural invasion in the T stage, seems questionable; a revision of the TNM classification is therefore required.
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13

Bai, Fang, and Wen Li Jin. "Parameters Evaluation for Aero-Engine Prognostic Health Management." Applied Mechanics and Materials 236-237 (November 2012): 192–96. http://dx.doi.org/10.4028/www.scientific.net/amm.236-237.192.

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Prognostic health-management of aero-engine’s fleet have features with multi-source and asynchronous. Cruise engine gas temperature (EGT) and Take-off EGT have always been the focus of evaluating gas performance and predicting the remaining life. The calculation method of EGT Margin was showed based on the introduction of the definition and classification of the EGT. It analyses not only the relationships between Cruise EGT and Take-off EGT but also each other’s main functions. Meanwhile, an instance was used to explain the disadvantages of using Cruise EGT to calculate life prognostics.
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Steinbach, Frank, Michael Stöckle, Roland Kiewel, Stefan Störkel, Raimund Stein, and Rudolf Hohenfellner. "Prognostic Parameters of Renal Cell Carcinoma." European Urology 24, no. 2 (1993): 279–85. http://dx.doi.org/10.1159/000474310.

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15

Störkel, S., W. Thoenes, G. H. Jacobi, U. Engelmann, and R. Lippold. "Prognostic Parameters of Renal Cell Carcinoma." European Urology 18, no. 2 (1990): 36–37. http://dx.doi.org/10.1159/000463959.

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16

Assié, Guillaume, Guillemette Antoni, Frédérique Tissier, et al. "Prognostic Parameters of Metastatic Adrenocortical Carcinoma." Journal of Clinical Endocrinology & Metabolism 92, no. 1 (2007): 148–54. http://dx.doi.org/10.1210/jc.2006-0706.

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Abstract Context: Prognostic parameters of metastatic adrenocortical carcinoma (ACC) are poorly characterized. Objective: The objective of the study was to describe the clinical presentation of metastatic ACC and determine prognostic factors for survival. Design: This was a retrospective cohort study (1988–2004). Setting: The study was conducted in an institutional practice. Patients: Participants included 124 consecutive patients with metastatic ACC, 70 from Gustave-Roussy Institute (main cohort) and 54 patients from the Cochin Hospital (validation cohort). Clinical data concerning all patients, histopathologic slides of primary tumors (44 in the main cohort and 40 in the validation cohort), and molecular biology data on 15 primary tumors (main cohort) were analyzed. Intervention: There was no intervention. Main Outcome: The main outcome was the specific survival after discovery of the first metastasis (Kaplan-Meier method). This included univariate analysis on the main cohort, confirmed on the validation cohort and then analyzed in a multivariate analysis. Results: In the main cohort, overall median survival was 20 months. In univariate analysis, the presence of hepatic and bone metastases, the number of metastatic lesions and the number of tumoral organs at the time of the first metastasis, a high mitotic rate (>20 per 50 high-power field), and atypical mitoses in the primary tumor predicted survival (P = 0.05, 0.003, 0.046, 0.001, 0.01, and < 0.001, respectively). The number of tumoral organs and a high mitotic rate were confirmed on the validation cohort (P = 0.009 and 0.03, respectively). These two parameters were confirmed in multivariate analysis (P = 0.0058 and 0.049). Conclusion: Metastatic ACC is a heterogeneous disease with poor outcome. The combination of the number of tumoral organs at the time of the first metastasis and the mitotic rate can predict different outcomes.
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17

Hoeger, P. H. "Prognostic parameters in Henoch-Schönlein purpura." British Journal of Dermatology 172, no. 5 (2015): 1191–92. http://dx.doi.org/10.1111/bjd.13723.

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18

Cipriani, Nicole A. "Prognostic Parameters in Differentiated Thyroid Carcinomas." Surgical Pathology Clinics 12, no. 4 (2019): 883–900. http://dx.doi.org/10.1016/j.path.2019.07.001.

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19

Schteingart, D. E. "Prognostic Parameters of Metastatic Adrenocortical Carcinoma." Yearbook of Endocrinology 2008 (January 2008): 263–64. http://dx.doi.org/10.1016/s0084-3741(08)79172-8.

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20

SCHERFIG, ERIK, JENS EDMUND, STEEN TINNING, and ERIK KROGH. "PROGNOSTIC PARAMETERS IN PARS PLANA VITRECTOMY." Acta Ophthalmologica 61, no. 5 (2009): 788–805. http://dx.doi.org/10.1111/j.1755-3768.1983.tb01460.x.

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21

Akhtar, Zahid Mahmood, Rabia Altaf, Muhammad Shahbaz Amin, and Seema Butt. "Relationship of Nottingham Prognostic Index with prognostic parameters of breast carcinoma." Pakistan Journal of Medical and Health Sciences 16, no. 6 (2022): 26–28. http://dx.doi.org/10.53350/pjmhs2216626.

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Background: Breast cancer (BC) is the commonest malignancy in the female and it is gaining its significance due to worldwide rising incidence. It is also important due to 2.5% higher incidence in Pakistan as compared to neighbouring countries. Nottingham prognostic index (NPI) is an important prognostic factor of BC. It provides information about survival and morbidity. There are significant variations in different studies. Aim: To carry out current study relating NPI with various histopathological parameters of BC. Methods: This was a descriptive cross-sectional study. The study was done at the Department of Pathology, King Edward Medical University Lahore with the collaboration of four surgical units of Mayo Hospital Lahore from 2010 to 2019. Total 137 cases of breast carcinoma were included. Information about age, grade, primary tumor size, axillary lymph node status and stage was entered in the pre designed proforma. NPI was calculated as 0.2xtumor size(cm)+lymph node grade. NPI was scored as excellent, good, moderate and poor and its correlation was calculated against primary tumor size, lymph node grade, tumor grade and stage. Results: We studied 137 cases of breast carcinoma with mean age 49.32±11.64 years. Mean NPI was 5.4±1.4 with range of 2.4 to 9.4. NPI scores in poor 65(47.4%) and moderate 61(44.5%) groups were significantly high as compared to good 10(7.3%) and excellent scores 1(0.7%). Most of the cases of poor NPI were in p T3 and p T4 whereas this was p T2 with moderate score. Poor score of NPI was significant in grade 3 which is in contrast to moderate score where grade 2 dominated the picture. Correlation of NPI with LNG was in favor of LNG 1 with good and moderate scores while LNG3 dominated in the poor group. In stage III, 49 cases (35.8%) were seen with poor score of NPI. Conclusion: NPI is an important prognostic parameter and it can be studied with different histopathological parameters to see correlation between them. In the current study majority of the cases of NPI scored at poor and moderate levels. Correlation coefficient was linear, strong and positive especially with LNG. Mean NPI has ascending correlation with these parameters. Thus NPI can be used as a prognostic indicator when comparing with histopathological parameters of BC. Keywords: Breast cancer, NPI, tumor grade, tumor stage, LNG
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22

Raikar, Poornima, B. Deepak Kumar, and Srinivasa Murthy V. "CD 117 Immunoexpression in Invasive Breast Carcinoma: Association with various prognostic parameters." Annals of Pathology and Laboratory Medicine 2, no. 12 (2018): A984–990. http://dx.doi.org/10.21276/apalm.2229.

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23

Doswell III, Charles A., and David M. Schultz. "On the Use of Indices and Parameters in Forecasting Severe Storms." E-Journal of Severe Storms Meteorology 1, no. 3 (2021): 1–22. http://dx.doi.org/10.55599/ejssm.v1i3.4.

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This paper discusses our concept of the proper (and improper) use of diagnostic variables in severe-storm forecasting. A framework for classification of diagnostic variables is developed, indicating the limitations of such variables and their suitability for operational diagnosis and forecasting. The utility of diagnostic indices and parameters as prognostic tools for forecasting is discussed, revealing the relevant issues in designing new diagnostic variables used for making weather forecasts. Finally, criteria required to claim that a new diagnostic variable represents an effective prognostic variable are proposed. We argue that few, if any, diagnostic variables have met these criteria for demonstrated utility at prognosis.
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Kasprzak, Annika, Kathrin Nachtkamp, Norbert Gattermann, and Ulrich Germing. "Assessing the Prognosis of Patients with Myelodysplastic Syndromes (MDS)." Cancers 14, no. 8 (2022): 1941. http://dx.doi.org/10.3390/cancers14081941.

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Prognostic stratification in patients with myelodysplastic syndrome (MDS) relies on a number of key factors. Combining such patient-related and disease-related prognostic parameters into useful assessment tools remains a challenge. The most widely used scoring systems include the international prognostic scoring system (IPSS), the revised IPSS (IPSS-R), the World Health Organization (WHO) Prognostic Scoring System (WPSS), and the new molecular IPSS (IPSS-M). Similar to the IPSS-R and the IPSS-M, the chronic myelomonocytic leukemia (CMML) prognostic scoring system (CPSS) and the CPSS molecular (CPSS-mol) are powerful and reliable prognostic tools that help to assess the individual prognosis of patients with CMML. The well-established prognostic assessment of MDS and CMML may be further augmented by additional disease-related parameters, such as somatic mutations, or patient-related factors, such as comorbidities. In this article, we briefly describe useful prognostic scoring systems for myelodysplastic syndromes and identify some open questions that require further investigation.
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Kim, Sung Gon, Bang Wool Eom, Hongman Yoon, Young-Woo Kim, and Keun Won Ryu. "Prognostic Value of Preoperative Systemic Inflammatory Parameters in Advanced Gastric Cancer." Journal of Clinical Medicine 11, no. 18 (2022): 5318. http://dx.doi.org/10.3390/jcm11185318.

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Background: The predictive value of various systemic inflammatory parameters has been reported. However, it is still unclear which inflammatory parameters are the best predictors of prognosis in advanced gastric cancer and what are their mechanisms of action. The aim of this study was to evaluate the association between preoperative systemic inflammatory parameters and overall survival (OS) in patients with advanced gastric cancer. Methods: This retrospective study included 489 patients with stage II/III advanced gastric cancer treated at the National Cancer Center, Republic of Korea, between January 2012 and December 2015. We divided the patients into survivors and non-survivors and compared their clinicopathological characteristics. Univariate and multivariate analyses using the Cox proportional hazards model were performed to evaluate the prognostic value of inflammatory parameters. Results: The absolute lymphocyte count was significantly higher in survivors (2.07 ± 0.62 × 103/µL vs. 1.88 ± 0.63 × 103/µL, p = 0.001). The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) were marginally lower in survivors. Survival analysis revealed that the NLR and PLR were independent prognostic factors for OS. Survival was significantly different depending on NLR and PLR in the same pathologic stages. Conclusions: NLR and PLR were independent prognostic factors for OS in patients with advanced gastric cancer. Regarding single inflammatory parameters, an elevated lymphocyte count was the only factor associated with a favorable prognosis. These results suggest that the enhanced immune function of patients affects their prognosis more than the increased systemic inflammatory response.
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Hescot, Segolene, Matthieu Faron, Manal Kordahi, et al. "Screening for Prognostic Biomarkers in Metastatic Adrenocortical Carcinoma by Tissue Micro Arrays Analysis Identifies P53 as an Independent Prognostic Marker of Overall Survival." Cancers 14, no. 9 (2022): 2225. http://dx.doi.org/10.3390/cancers14092225.

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Advanced adrenocortical carcinoma (ACC) has poor but heterogeneous prognosis. Apart from Ki67 index, no prognostic or predictive biomarker has been validated in advanced ACC, so far. We aimed at analyzing expression of a large panel of proteins involved in known altered pathways in ACC (cell cycle, Wnt/ß-catenin, methylation) to identify and prioritize potential prognostic or predictive parameters metastatic ACC population. We conducted a retrospective multicentric study. Overall survival (OS) and partial response according to RECIST 1.1 were primary endpoints. TMA was set up and 16 markers were analyzed. Modified ENSAT and GRAS parameters were characterized for prognostic adjustment. Results: We included 66 patients with a mean age at metastatic diagnosis of 48.7 ± 15.5 years. Median survival was 27.8 months. After adjustment to mENSAT-GRAS parameters, p53 and PDxK were prognostic of OS. No potential biomarker has been identified as predictive factor of response. We identified for the first time P53 as an independent prognostic marker of metastatic adrenocortical carcinoma after mENSAT-GRAS parameter adjustment. Prognostic impact of Wnt/ß-catenin alterations was not confirmed in this cohort of metastatic ACC.
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Esen, Hasan, Gülay Turan, Hamdi Arbağ, and F. Cavide Sönmez. "Favorable Prognosis Variant Acinic Cell Carcinoma in Parotid Gland And Prognostic Parameters." European Journal of Therapeutics 16, no. 1 (2010): 23–25. http://dx.doi.org/10.58600/eurjther.2010-16-1-1318-arch.

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Asinic cell carcinoma, previously known as 'acinic cell tumor'', is a neoplasm demostrating cytologic differentiation serous acinar cells. Differentiation sometimes only focally. This neoplasm does not show myoepitelial participation. The most frequent sites of occurence are the parotid gland. The most important prognostic indicators for acinic cell carcinoma are clinical stage and status of the resection margin. Frequent mitoses, high proliferative index (Ki67>%5), fokal necrosis, perineural invasion, gross invasion, desmoplasia, atypia and depletion of lymphocytes in the stroma have been associated with more frequent recurrens and metastases.
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28

Pierscianek, Daniela, Marvin Darkwah Oppong, Yahya Ahmadipour, et al. "Electrolyte and renal disorders in patients with newly diagnosed glioblastoma." Future Oncology 17, no. 34 (2021): 4711–19. http://dx.doi.org/10.2217/fon-2020-1312.

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Purpose: Disturbances of electrolytes and renal function have been linked to the prognosis of critically ill patients and recently also of cancer patients. This study aimed to assess electrolyte and renal disorders in glioblastoma patients and evaluate their prognostic effect. Methods: Medical records of patients with newly diagnosed glioblastoma between 2005 and 2018 were retrospectively reviewed for electrolyte and renal function parameters and for demographic, clinical and outcome parameters. Results: Electrolyte and renal function disorders were associated with poorer survival in univariate and Kaplan–Meier analysis. Multivariate analysis revealed hypochloremia as an independent prognostic factor for overall and 1-year survival. Conclusion: Only hypochloremia showed an association with glioblastoma prognosis, independent of other known prognostic factors, as age or molecular status.
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29

Wahn, U. "Prognostic value of immunologic parameters in neonates." Allergy 54, s56 (1999): 14–15. http://dx.doi.org/10.1111/j.1398-9995.1999.tb04427.x.

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30

Ben-Meir, Assaf, Yair Erez, Hen Yitzhak Sela, David Shveiky, Avi Tsafrir, and Yossef Ezra. "Prognostic parameters for successful external cephalic version." Journal of Maternal-Fetal & Neonatal Medicine 21, no. 9 (2008): 660–62. http://dx.doi.org/10.1080/14767050802244938.

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31

Mooy, Cornelia M., and P. T. V. M. De Jong. "Prognostic parameters in uveal melanoma: a review." Survey of Ophthalmology 41, no. 3 (1996): 215–28. http://dx.doi.org/10.1016/s0039-6257(96)80024-5.

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32

Strong, Scott A. "9 Prognostic parameters of Crohn's disease recurrence." Baillière's Clinical Gastroenterology 12, no. 1 (1998): 167–77. http://dx.doi.org/10.1016/s0950-3528(98)90091-4.

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Germing, Ulrich, Corinna Strupp, Manuel Aivado, and Norbert Gattermann. "New prognostic parameters for chronic myelomonocytic leukemia?" Blood 100, no. 2 (2002): 731–33. http://dx.doi.org/10.1182/blood-2002-01-0330.

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34

DE SMET, M. "Assessing macular edema- prognostic parameters by OCT." Acta Ophthalmologica 87 (September 2009): 0. http://dx.doi.org/10.1111/j.1755-3768.2009.2112.x.

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35

Corbett, Jade-Marie, Kwok M. Ho, and Stephen Honeybul. "Prognostic significance of abnormal hematological parameters in severe traumatic brain injury requiring decompressive craniectomy." Journal of Neurosurgery 132, no. 2 (2020): 545–51. http://dx.doi.org/10.3171/2018.10.jns182293.

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OBJECTIVEHematological abnormalities after severe traumatic brain injury (TBI) are common, and are associated with a poor outcome. Whether these abnormalities offer additional prognostic significance over and beyond validated TBI prognostic models is uncertain.METHODSThis retrospective cohort study compared the ability of admission hematological abnormalities to that of the IMPACT (International Mission for Prognosis and Analysis of Clinical Trials) prognostic model to predict 18-month neurological outcome of 388 patients who required a decompressive craniectomy after severe TBI, between 2004 and 2016, in Western Australia. Area under the receiver operating characteristic (AUROC) curve was used to assess predictors’ ability to discriminate between patients with and without an unfavorable outcome of death, vegetative state, or severe disability.RESULTSOf the 388 patients included in the study, 151 (38.9%) had an unfavorable outcome at 18 months after decompressive craniectomy for severe TBI. Abnormalities in admission hemoglobin (AUROC 0.594, p = 0.002), plasma glucose (AUROC 0.592, p = 0.002), fibrinogen (AUROC 0.563, p = 0.036), international normalized ratio (INR; AUROC 0.645, p = 0.001), activated partial thromboplastin time (AUROC 0.564, p = 0.033), and disseminated intravascular coagulation score (AUROC 0.623, p = 0.001) were all associated with a higher risk of unfavorable outcome at 18 months after severe TBI. As a marker of inflammation, neutrophil to lymphocyte ratio was not significantly associated with the risk of unfavorable outcome (AUROC 0.500, p = 0.998). However, none of these parameters, in addition to the platelet count, were significantly associated with an unfavorable outcome after adjusting for the IMPACT predicted risk (odds ratio [OR] per 10% increment in risk 2.473, 95% confidence interval [CI] 2.061–2.967; p = 0.001). After excluding 8 patients (2.1%) who were treated with warfarin prior to the injury, there was a suggestion that INR was associated with some additional prognostic significance (OR 3.183, 95% CI 0.856–11.833; p = 0.084) after adjusting for the IMPACT predicted risk.CONCLUSIONSIn isolation, INR was the best hematological prognostic parameter in severe TBI requiring decompressive craniectomy, especially when patients treated with warfarin were excluded. However, the prognostic significance of admission hematological abnormalities was mostly captured by the IMPACT prognostic model, such that they did not offer any additional prognostic information beyond the IMPACT predicted risk. These results suggest that new prognostic factors for TBI should be evaluated in conjunction with predicted risks of a comprehensive prognostic model that has been validated, such as the IMPACT prognostic model.
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Sorici, Galina, Nadejda Diaconu, Irina Kivirijik, Tatiana Cuzor, and Aurel Grosu. "Prognostic echocardiographic parameters in hospitalized patients with pulmonary embolism." Bulletin of the Academy of Sciences of Moldova. Medical Sciences 78, no. 1 (2024): 75–80. http://dx.doi.org/10.52692/1857-0011.2024.1-78.09.

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Pulmonary embolism (PE) is considered one of the most common cardiovascular diseases with considerable mortality. Echocardiography remains an important investigation in the evaluation of these patients, with some echocardiographic parameters playing an incremental role in prognostic evaluation.Objectives: To determine the spectrum of echocardiographic changes in patients hospitalized with pulmonary embolism at the Institute of Cardiology of the Republic of Moldova and to highlight parameters with significant prognostic value in relation to risk scores for mortality stratification in PE. Materials and methods: We prospectively enrolled 168 patients admitted to the Institute of Cardiology. All patients were evaluated by transthoracic echocardiography. Results: Parameters most associated with in-hospital mortality at 30 days were: right atrial area (RA) >18cm2 (p=0.007), tricuspid valve regurgitation (TR) grade (p=0.002), tissue systolic velocity of the anterior wall of the right ventricle (RV) (p=0.03), inferior vena cava diameter (p=0.04), RV/LV ratio >1.0 (p=0.04), and TAPSE/PSAP index <0.4 (p<0.008). Conclusions: Echocardiographic parameters such as tricuspid valve regurgitation grade, RA area, tissue systolic velocity of the anterior RV wall, TAPSE/PSAP index, and interventricular ratio have additive value in evaluating prognosis in patients with PE.
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Semenov, D. V., R. V. Orlova, V. I. Shirokorad, et al. "Analysis of the effect of clinical and laboratory parameters on survival in patients with metastatic renal cell cancer with intermediate prognosis according to IMDC (International mRCC Database Consortium)." Urology Herald 11, no. 2 (2023): 110–21. http://dx.doi.org/10.21886/2308-6424-2023-11-2-110-121.

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Introduction. Most patients with metastatic renal cell carcinoma (mRCC) who received systemic therapy are classified into as intermediate risk group according to the International mRCC Database Consortium (IMDC) assessment. However, survival differs in patients with one and two unfavourable prognostic risk factors.Objective. To analyze the impact of possible clinical and laboratory parameters on survival in mRCC patients with intermediate prognosis according to IMDC in the presence of one or two unfavourable prognostic risk factors.Materials & methods. A retrospective analysis of data from 316 mRCC patients with intermediate prognosis receiving systemic therapy was carried out. The presence and effect on survival of the following laboratory parameters were compared: hemoglobin, neutrophil count, LDH, platelet count, alkaline phosphatase, serum calcium level, ESR, and emphasis was also placed on the time of metastases appearance. Overall survival (OS), post-progression survival (PPS), and 3- and 5-year survival were evaluated.Results. The overall 3- and 5-year survival rate for subgroups with one and two unfavourable prognostic risk factors were 85.2% ± 1.8% and 58.1 ± 1.6%; 79.1% ± 1.7% and 35.6  1.6%, respectively (p < 0.001). Three- and 5-year PPS for both subgroups amounted to 66.1% ± 1.6% and 21.8% ± 1.4%; 45.2% ± 1.5% and 12.2% ± 1.3%, respectively (p < 0.001). Median for OS was 61 and 51 months and PPS was 50 and 32 months respectively (p <0.001). No statistically significant difference was found in the frequency of gradations of the investigated laboratory indicators with a predictive effect on prognosis, depending on the number of a unfavourable prognostic risk factors. There were also no significant differences in survival rates when laboratory parameters deviated from the normal, except for hemoglobin: OS in patients with one prognostic factor is significantly higher with normal hemoglobin (p < 0.05). In the future, considering the absence of influence of the selected factors on survival rates with their obvious significant differences in patients with one and two prognostic factors, the influence of the time of appearance of metastases (synchronous / metachronous) was analysed: all survival parameters were significantly worse in patients with synchronous metastases. Furthermore, OS in patients with metachronous metastases with the same relapse-free period was significantly better in patients with one prognostic factor according to IMDC.Conclusions. The presence of one or two prognostic factors significantly affects the indicators of 3 and 5-year overall survival and PPS in patients with an intermediate prognosis of mRCC, while laboratory parameters do not affect survival, except for hemoglobin levels, the time of metastases appearance has a significant effect, and the time of metastases appearance has a significant effect.
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Dondi, Francesco, Maria Gazzilli, Domenico Albano, et al. "Prognostic Role of Pre- and Post-Treatment [18F]FDG PET/CT in Squamous Cell Carcinoma of the Oropharynx in Patients Treated with Chemotherapy and Radiotherapy." Medical Sciences 12, no. 3 (2024): 36. http://dx.doi.org/10.3390/medsci12030036.

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Background: The prognostic role of imaging with [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) in oropharynx cancer (OPC) has been demonstrated in the past. The aim of this study was to assess the prognostic impact of both baseline and post-treatment PET/CT in patients with OPC and treated with chemo- and/or radiotherapy. Methods: The PET/CT parameters of scans performed before and after therapy were collected and analyzed to find significant prognosticators for progression-free survival (PFS) and overall survival (OS). Human papillomavirus (HPV) infection’s influence on the prognosis was also taken into account. Results: A total of 66 patients were included in the study. The staging volumetric parameters of PET/CT were significant prognosticators for OS, while the same parameters were affordable predictors for PFS at the restaging evaluation. No significant correlations between HPV infection and PET/CT parameters were reported. Conclusion: The prognostic role of volumetric [18F]FDG PET/CT parameters in patients with OPC was reported.
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ien, Indr, Donata Mikalauskien, and Zoja Miknien. "The prognostic importance of physiological and biochemical parameters in horses afflicted with colic." Open Veterinary Journal 14, no. 8 (2024): 1801. http://dx.doi.org/10.5455/ovj.2024.v14.i8.8.

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Background: Colic, a primary cause of illness and death in horses, necessitates the development of improved prognostic tools. Aim: The aim of this study was to investigate the prognostic significance of physiological and biochemical parameters in horses suffering from colic. Methods: A comprehensive clinical evaluation of 117 horses included assessment of heart rate, mucous membranes, capillary refill time, rectal temperature, respiratory rate, gut motility, reflux, and limb pulse strength. Results: Stomach reflux, absence of gut noises, and increased heart rate (mean increase of 12 bpm) strongly correlate with a poor prognosis. Prolonged capillary refill time (mean increase of 3 seconds), rectal temperature (over 38.5°C), elevated packed cell volume (mean increase of 4%), and blood lactate levels (mean increase of 5 mmol/L) underscore the significance of these markers. Notably, blood lactate (p < 0.001), gut noises (p < 0.05), and heart rate (p < 0.001) demonstrate the highest predictive significance based on statistical analysis. Conclusion: Future research should investigate the prognostic potential of additional parameters and assess the impact of recommended treatments on colic prognosis. This data-driven study emphasizes the critical role of early recognition and thorough assessment in colic cases, offering vital insights into improving equine healthcare and mitigating mortality rates.
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de Morais, Everton Freitas, Hannah Gil de Farias Morais, Roseana de Almeida Freitas, and Ricardo D. Coletta. "Prognostic Significance of Histopathological Parameters for Salivary Gland Adenoid Cystic Carcinoma." Dentistry Journal 11, no. 11 (2023): 262. http://dx.doi.org/10.3390/dj11110262.

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Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor that accounts for approximately 1% of all head and neck cancers. Despite its initial indolent behavior, long-term survival is poor due to locoregional recurrence in approximately 40% and distant metastasis in up to 60% of patients who undergo radical treatment. The histological parameters of ACC and the combination of these parameters in histopathological grading systems provide valuable prognostic information about the clinical course of the disease. Within this context, this review aims to analyze the impact of histopathological parameters, individual or combined in histopathological grading systems of malignancy, on ACC prognosis. Individual histopathological parameters such as solid pattern, presence of tumor necrosis, high-grade transformation, dominance of the epithelial component, presence of perineural and lymphovascular invasion, and positive surgical margins have negative impacts on the survival of patients with ACC. There are currently four histopathological grading systems for ACC; however, few studies have validated these systems and most of them explored small cohorts with short follow-up. Considering that the application of grading systems has been associated with ACC prognosis, a broader validation will allow not only their use for prognostic prediction but also assist in treatment planning.
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Ryś, Janusz, Agnieszka Harazin-Lechowska, Anna Kruczak, et al. "Sarcomas and malignant mixed mesodermal tumours of the uterus – Diagnosis and prognostic significance of selected morphological parameters." Diagnostyka Laboratoryjna 53, no. 4 (2017): 205–10. http://dx.doi.org/10.5604/01.3001.0013.7983.

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Sarcomas and malignant mixed mesodermal tumours of the uterus (MMMT), also called carcinosarcomas, belong to rare uterine ne- oplasms usually characterised by very aggressive clinical behaviour. Due to their low incidence, unknown etiology as well as complex molecular characteristics, until now neither prognostic factors responsible for unfavourable prognosis nor optimal treatment methods have been definitely established. This study attempts to determine prognostic significance of selected morphological parameters. Based on the analysis of primary uterine neoplasms in 43 women (including 30 sarcomas and 13 MMMT) it was shown that prognosis is dependent on the histological type of the neoplasm. The worst prognosis was observed in patients with carcinosarcomas and high- grade endometrial stromal sarcomas. Additionally, it was demonstrated that both aforementioned neoplasms occur in significantly older age groups.
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Cerruto, Carlos A., Erwin A. Brun, David Chang, and Paul H. Sugarbaker. "Prognostic Significance of Histomorphologic Parameters in Diffuse Malignant Peritoneal Mesothelioma." Archives of Pathology & Laboratory Medicine 130, no. 11 (2006): 1654–61. http://dx.doi.org/10.5858/2006-130-1654-psohpi.

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Abstract Context.—Diffuse malignant peritoneal mesothelioma is currently regarded as a rare and lethal primary tumor arising from the peritoneal membrane. In the past, treatment plans with variable combinations of surgery and systemic chemotherapy were associated with a median survival of approximately 1 year. Standardized treatments using cytoreductive surgery and perioperative intraperitoneal chemotherapy have extended this survival. Objective.—To critically analyze the prognostic significance of histomorphologic parameters as a determinant of survival. Design.—Sixty-two consecutive patients with diffuse malignant peritoneal mesothelioma in whom data were prospectively accumulated were retrospectively analyzed by 14 different histomorphologic parameters. The influences of these pathologic characteristics on survival were critically statistically evaluated. Results.—In a univariate analysis, histologic type, nuclear/nucleolar size, stroma, depth of invasion into the bowel, atypical mitoses, mitotic index, necrosis, lymph node involvement, and chromatin patterns were found to be significant. In the multivariate analysis, histologic type and nuclear/nucleolar size remained as determinant histomorphologic characteristics. Use of biphasic/sarcomatoid histologic type as a poor prognostic characteristic was limited in that only 8% of patients showed this histology. Conclusions.—Histomorphologic parameters carry prognostic significance in predicting the survival of patients with diffuse malignant peritoneal mesothelioma when treated in a standardized fashion using cytoreductive surgery and perioperative intraperitoneal chemotherapy. Nuclear/nucleolar size was found to be a reliable histomorphologic assessment available to assess prognosis in these patients.
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Cibula, David, Ivana Pinkavova, Ladislav Dusek, et al. "Local Control After Tailored Surgical Treatment of Early Cervical Cancer." International Journal of Gynecologic Cancer 21, no. 4 (2011): 690–98. http://dx.doi.org/10.1097/igc.0b013e318213653d.

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Background:It was the aim of our study to analyze oncological outcome and prognostic parameters in patients with early stages cervical cancer after tailored and well-standardized surgical treatment with an adequate follow-up.Methods:Oncological outcome and prognostic parameters were evaluated in a group of 192 patients with cervical cancer stages IA2 to 2B who had undergone radical hysterectomy (n = 171), radical parametrectomy (n = 12), or radical trachelectomy (n = 9). Procedures were classified as type B (n = 72), type C1 nerve sparing (n = 103), or type C2 (n = 17).Results:Event-free and overall 5-year survivals probabilities reached 92.7% (confidence interval, 89.5%-95.9 %) and 94.1% (confidence interval, 90.9%-97.3 %). There was only 1 isolated pelvic recurrence found of the total of 10 recurrences. Adjuvant radiotherapy was given to only 22% of patients. The most significant independent prognostic parameters in stage IB tumors were lymph node status, histological type, and tumor volume, whereas in stage II, the parameters included histological type and tumor volume, the latter being inversely related to the prognosis.Conclusions:We have shown an excellent prognosis, especially local control, after tailored surgical treatment of stages IA2 to IIB of cervical cancer, with low prevalence of adjuvant treatment. Different prognostic parameters were observed for stages IB1/IB2 and IIA/B.
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Sydorchuk, R. I., O. Y. Khomko, I. M. Plehutsa, R. P. Knut, and O. M. Plehutsa. "ASSESSMENT OF SEVERITY IN PATIENTS WITH ACUTE PERITONITIS, COMPLICATED BY ABDOMINAL SEPSIS." Modern medical technologies 43, no. 4 (2019): 75–78. http://dx.doi.org/10.34287/mmt.4(43).2019.14.

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Abstract Abdominal sepsis (AS) is one of the most important problems in modern abdominal surgery. Prediction of AS and complications remains a challenge for modern surgery. The aim of the study is to evaluate the prognostic and diagnostic value of clinical and laboratory parameters in order to substantiate the prognostic complex for patients with AS and to improve existing systems for assessing the severity of patients by modification aimed on adapting to the capabilities of clinics.The proposed modification of the severity scoring scale APACHE II, based on the analysis of clinical and laboratory data obtained in 183 patients with acute peritonitis and abdominal sepsis. The complex of physiological parameters and their prognostic significance in AS was determined by in-depth statistical analysis and determination of predicting values.Most of the analyzed indicators had a likely positive prognostic value in the diagnosis and prognosis of AS. At the same time, the predictive value of the qSOFA scale at low values is negligible. Statistically insufficient prognostic value was obtained for increased temperature above 38,0 °C. The data obtained formed the basis for the development of a digital AS and complications prediction system by modifying the APACHE II scale.The proposed patient' severity scale is accessible and sufficiently informative for use in patients with peritonitis and AS. It is recommended that at least two systems for assessing the severity of a patient's condition be combined. Keywords. Acute peritonitis, abdominal sepsis, physiological parameters, prognosis, diagnosis, risk ratio, modification of APACHE score.
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Mijović, Milica, Vladica Nedeljković, Danica Vukićević, et al. "Diagnostic, prognostic and predictive parameters in prostate cancer." Praxis medica 49, no. 3-4 (2020): 43–49. http://dx.doi.org/10.5937/pramed2004043m.

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Prostate cancer (CP) is the most common malignancy in men in America, while it is the second most common in Europe. It is responsible for about 10% of cancer deaths in the same population. It is clinically manifested in various forms, from slow-growing to aggressive forms with pronounced metastatic potential. Diagnosis is made by a well-defined algorithm, which begins with the determination of serum prostate specific antigen values and ends with prostate biopsy as the "gold standard". Pathohistological diagnostic criterias are based on architectural, cytoplasmic, nuclear and characteristics of intraluminal structures, as well as periacinar cleftings, which are deffined as helpfull diagnostic criteria of undoubted importance. Prognostic and predictive parameters are classified into three categories. Some of them are an integral part of routine pathohistologicat report, while others are considered as the diagnostic process progresses. Modern knowledge introduces biomarkers into the everyday practice of personalized medicine, especially when is necessary to treat prostate cancer patients.
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Taralli, Silvia, Romina Grazia Giancipoli, Carmelo Caldarella, et al. "The Prognostic Value of 18F-FDG PET Imaging at Staging in Patients with Malignant Pleural Mesothelioma: A Literature Review." Journal of Clinical Medicine 11, no. 1 (2021): 33. http://dx.doi.org/10.3390/jcm11010033.

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Malignant pleural mesothelioma (MPM) is an aggressive malignancy, frequently diagnosed at locally-advanced/metastatic stages. Due to a very poor prognosis and limited treatment options, the need to identify new prognostic markers represents a great clinical challenge. The prognostic role of metabolic information derived from Positron Emission Tomography (PET) with 18F-Fluoro-deoxy-glucose (18F-FDG) has been investigated in different MPM settings, however with no definitive consensus. In this comprehensive review, the prognostic value of FDG-PET imaging exclusively performed at staging in MPM patients was evaluated, conducting a literature search on PubMed/MEDLINE from 2010 to 2020. From the 19 selected studies, despite heterogeneity in several aspects, staging FDG-PET imaging emerges as a valuable prognostic biomarker, with higher tumor uptake predictive of worse prognosis, and with volumetric metabolic parameters like Metabolic Tumor Volume, (MTV) and Total Lesion Glycolisis (TLG) performing better than SUVmax. However, PET uptake parameters were not always confirmed as independent prognostic factors, especially in patients previously treated with pleurodesis and with a non-epithelioid histotype. Future prospective studies in larger and clinically homogeneous populations, and using more standardized methods of PET images analysis, are needed to further validate the value of staging FDG-PET in the prognostic MPM stratification, with a potential impact on better patient-tailored treatment planning, in the perspective of personalized medicine.
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Qin, Fanbo, Junyong Zhang, Jianping Gong, and Wenfeng Zhang. "Identification and Validation of a Prognostic Model Based on Three Autophagy-Related Genes in Hepatocellular Carcinoma." BioMed Research International 2021 (March 12, 2021): 1–15. http://dx.doi.org/10.1155/2021/5564040.

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Background. Accumulating studies have demonstrated that autophagy plays an important role in hepatocellular carcinoma (HCC). We aimed to construct a prognostic model based on autophagy-related genes (ARGs) to predict the survival of HCC patients. Methods. Differentially expressed ARGs were identified based on the expression data from The Cancer Genome Atlas and ARGs of the Human Autophagy Database. Univariate Cox regression analysis was used to identify the prognosis-related ARGs. Multivariate Cox regression analysis was performed to construct the prognostic model. Receiver operating characteristic (ROC), Kaplan-Meier curve, and multivariate Cox regression analyses were performed to test the prognostic value of the model. The prognostic value of the model was further confirmed by an independent data cohort obtained from the International Cancer Genome Consortium (ICGC) database. Results. A total of 34 prognosis-related ARGs were selected from 62 differentially expressed ARGs identified in HCC compared with noncancer tissues. After analysis, a novel prognostic model based on ARGs (PRKCD, BIRC5, and ATIC) was constructed. The risk score divided patients into high- or low-risk groups, which had significantly different survival rates. Multivariate Cox analysis indicated that the risk score was an independent risk factor for survival of HCC after adjusting for other conventional clinical parameters. ROC analysis showed that the predictive value of this model was better than that of other conventional clinical parameters. Moreover, the prognostic value of the model was further confirmed in an independent cohort from ICGC patients. Conclusion. The prognosis-related ARGs could provide new perspectives on HCC, and the model should be helpful for predicting the prognosis of HCC patients.
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Maier, W., and J. Schipper. "Prognostic relevance of anamnestic and diagnostic parameters in low-frequency hearing impairment." Journal of Laryngology & Otology 120, no. 8 (2006): 613–18. http://dx.doi.org/10.1017/s002221510600137x.

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Low-frequency hearing impairment (LFHI) is mainly attributed to endolymphatic hydrops and has a great variety of possible outcomes. At present, no conservative therapeutic regimen has proven to be ‘gold-standard’, and information about the prognostic indicators of LFHI is scarce.In a retrospective investigation, we evaluated the records of 90 patients who had been treated with infusions improving blood perfusion. In patients lacking complete remission, dehydration infusion therapy was added. We also undertook audiometric follow up. We calculated the outcomes after infusion therapy, dehydration therapy and after long-time hearing follow up, and we determined the prognostic relevance of several parameters of anamnesis and clinical examination to outcomes, for both therapeutic interventions and long-time hearing.The prognosis of LFHI was significantly correlated to certain anamnestic and clinical parameters; a short duration of the disease, lack of vertigo and female gender implied a better outcome. The pretherapeutic hearing threshold was an important prognostic factor; the outcome was significantly worse in patients with distinct hearing impairment in low or high frequencies, compared with that in patients with little hearing loss. Whereas vertigo was a negative prognostic factor, the results of quantitative vestibular testing were irrelevant to the outcome. The glycerol test failed to predict the effectiveness of dehydration therapy and lacked any value in predicting prognosis.These results allow the clinician to focus the anamnesis and diagnostic examination on prognostically relevant parameters, thus enabling a better estimation of the long-term disease course and improved counselling of patients. Furthermore, these results help to distinguish valuable from irrelevant diagnostic procedures.
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Orekhov, Nikolay A., Tatiana V. Kirichenko, Veronika A. Myasoedova, Andrey V. Omelchenko, Alexander N. Orekhov, and Igor A. Sobenin. "SIGNIFICANCE ASSESSMENT OF LDL-CONTAINING CIRCULATUNG IMMUNE COMPLEXES IN DIAGNOSTICS AND PROGNOSTICATION OF CAROTID ATHEROSCLEROSIS." Complex Issues of Cardiovascular Diseases 13, no. 3 (2024): 47–53. http://dx.doi.org/10.17802/2306-1278-2024-13-3-47-53.

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HighlightsLow-density lipoprotein cholesterol (LDL)-containing circulating immune complexes (LDL-CIC) reflect impaired lipid metabolism and systemic inflammation.Serum level of LDL-CIC is sensitive and specific diagnostic and prognostic marker of carotid atherosclerosis.The combination of age and serum LDL-CIC is particularly valuable for the prognosis of carotid atherosclerosis. Aim. Recent studies suggested that increased level of low-density lipoprotein cholesterol (LDL)-containing circulating immune complexes (LDL-CIC) might have high diagnostic value in regards to clinical and asymptomatic atherosclerosis. The aim was to study prognostic significance of LDL-CIC.Methods. The two-year study included 98 men. Each included patient underwent the following studies: carotid intima-media thickness, total cholesterol, low- and high-density lipoprotein cholesterol, triglycerides, and LDL-CIC.Results. Among these parameters, low-density lipoprotein cholesterol and LDL-CIC were significantly associated with severity and prognosis of carotid atherosclerosis. LDL-CIC has the highest sensitivity and specificity in diagnostics of carotid atherosclerosis when combined with age. Other parameters do not affect the prognostic significance of LDL-CIC.Conclusion. The results suggest that LDL-CIC can be used for diagnostics and prognosis of atherosclerosis.
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Pedersen, Mette Abildgaard, Thomas Baad-Hansen, Lars C. Gormsen, et al. "Inclusion of Metabolic Tumor Volume in Prognostic Models of Bone and Soft Tissue Sarcoma Increases the Prognostic Value." Cancers 15, no. 3 (2023): 816. http://dx.doi.org/10.3390/cancers15030816.

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Sarcomas are rare and have a high mortality rate. Further prognostic classification, with readily available parameters, is warranted, and several studies have examined circulating biomarkers and PET parameters separately. This single-site, retrospective study aimed to examine the prognostic values of several scoring systems in combination with PET parameters. We included 148 patients with sarcoma, who were treated and scanned at Aarhus University Hospital from 1 January 2016 to 31 December 2019. The Akaike information criterion and Harrell’s concordance index were used to evaluate whether the PET parameters added prognostic information to existing prognostic models using circulating biomarkers. Of the PET parameters, metabolic tumor volume (MTV) performed best, and when combined with the existing prognostic models, the prognostic value improved in all models. Backward stepwise selection was used to create a new model, SBSpib, which included albumin, lymphocytes, and one PET parameter, MTV. It has scores ranging from zero to three and increasing hazard ratios; HR = 4.83 (1.02–22.75) for group one, HR = 7.40 (1.6–33.42) for group two, and HR = 17.32 (3.45–86.93) for group three. Consequently, implementing PET parameters in prognostic models improved the prognostic value. SBSpib is a new prognostic model that includes both circulating biomarkers and PET parameters; however, validation in another sarcoma cohort is warranted.
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