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Relevant bibliographies by topics / Programmed -1 ribosomal frameshift / Dissertations / Theses

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Dissertations / Theses on the topic 'Programmed -1 ribosomal frameshift'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Bailey, Brenae L. "Stochastic Models of –1 Programmed Ribosomal Frameshifting." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/320007.

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Many viruses can produce multiple proteins from a single mRNA sequence by encoding the proteins in overlapping genes. One mechanism that causes the ribosomes of infected cells to decode both genes is –1 programmed ribosomal frameshifting. In this process, structural elements of the viral mRNA signal the ribosome to shift reading frames at a specific point. Although –1 frameshifting has been recognized since 1985, the mechanism is not well understood. I have developed a stochastic model of mRNA translation that includes the possibility of a –1 frameshift at any codon. The transition probabilit

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2

Neeriemer, Jessica Joy. "Programmed ribosomal frameshifting in SARS-CoV and HIV-1." College Park, Md.: University of Maryland, 2007. http://hdl.handle.net/1903/7713.

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Thesis (M.S.) -- University of Maryland, College Park, 2007.<br>Thesis research directed by: Dept. of Cell Biology & Molecular Genetics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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3

Nikolić, Emily Isabel Cinzia. "Structural and functional studies of programmed -1 ribosomal frameshifting." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607928.

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4

King, Louise Margaret. "Studies of programmed -1 ribosomal frameshifting in virus systems." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615622.

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5

Ramarao, Rachana. "Molecular studies of programmed -1 ribosomal frameshifting and translational readthrough." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615726.

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6

Pennell, Simon John. "Structural studies of RNA pseudoknots involved in programmed -1 ribosomal frameshifting." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620323.

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7

Girnary, Roseanne Waheeda. "Structural and functional studies of the stimulatory RNAs involved in programmed -1 ribosomal frameshifting and translational readthrough." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612716.

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8

Caliskan, Neva [Verfasser], Marina [Akademischer Betreuer] Rodnina, Holger [Akademischer Betreuer] Stark, and Ralf [Akademischer Betreuer] Ficner. "Mechanisms of programmed ribosomal -1 frameshifting in bacteria / Neva Caliskan. Gutachter: Holger Stark ; Ralf Ficner. Betreuer: Marina Rodnina." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://d-nb.info/1054191476/34.

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9

Théberge-Julien, Gabriel. "Sélection de peptides altérant le changement de cadre de lecture -1 programmé du VIH-1." Thèse, 2008. http://hdl.handle.net/1866/7245.

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10

Léger, Mélissa. "Étude du mécanisme du changement programmé -1 du cadre de lecture par le ribosome." Thèse, 2008. http://hdl.handle.net/1866/6588.

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11

Charbonneau, Johanie. "Influence de l'initiation de la traduction sur le changement programmé du cadre de lecture en -1 responsable de la synthèse des enzymes du virus de l’immunodéficience humaine de type 1." Thèse, 2012. http://hdl.handle.net/1866/8568.

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Le virus de l’immunodéficience humaine de type 1 (VIH-1) est responsable du syndrome de l’immunodéficience acquise (SIDA). Il faut identifier de nouvelles cibles pour le développement d’agents anti-VIH-1, car ce virus développe une résistance aux agents présentement utilisés. Notre but est d’approfondir la caractérisation de l’étape du changement de cadre de lecture ribosomique en -1 (déphasage -1) nécessaire à la production du précurseur des enzymes du VIH-1. Ce déphasage est programmé et effectué par une minorité de ribosomes lorsqu’ils traduisent la séquence dite glissante à un endroit spéc

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12

Caliskan, Neva. "Mechanisms of programmed ribosomal -1 frameshifting in bacteria." Doctoral thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-0022-5F19-2.

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13

Lin, Szu-Chieh, and 林思潔. "Regulation of -1 programmed ribosomal frameshifting by a metabolite-responsive RNA pseudoknot." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/52817314212305492649.

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碩士<br>國立中興大學<br>生物化學研究所<br>98<br>There are many ways to regulate translation, and -1 programmed ribosomal frameshifting (-1 PRF) is one of them. -1 PRF is found in many type of viruses which can regulate the ratio of essential proteins by -1 PRF. Efficient -1 PRF requires two RNA elements. The first one is a hepta-nucleotide slippery sequence, located in the 5’ end named “slippery site”. The second element is a stimulator RNA structure, located 5-7 nucleotides downstream of the slippery site. There are many kinds of structures that can be a stimulator RNA, such as a simple hairpin in HIV-1, th

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14

Chen, Cheng-Yu, and 陳政裕. "The functional study of -1 programmed ribosomal frameshifting attenuator in different cells." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/ncuz47.

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碩士<br>國立中興大學<br>生物化學研究所<br>100<br>The translation processes in distinct organisms follow the genetic central dogma that messenger RNAs (mRNA) are transcribed from DNA, and proteins are translated from messenger RNA. However, translational process can be regulated by -1 programmed ribosomal frameshifting (-1 PRF) to produce particular fusion proteins, and is caused by the slippery sequence (XXXYYYZ) and stimulator RNA structure within mRNA sequences. We already demonstrated that the DU177 pesudoknot structure could stimulate -1PRF and an RNA hairpin 6BPGC can serve as a -1 PRF attenuator to red

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15

Lin, Ya-Hui, and 林雅惠. "Regulation of -1 Programmed Ribosomal Frameshifting by Synthetic Riboswitch in Human Cells." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/61481004067063697123.

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博士<br>國立中興大學<br>生物化學研究所<br>103<br>-1 programmed ribosomal frameshifting (-1 PRF) is a mechanism to regulate gene expression at the level of protein synthesis. -1 PRF occurs upon ribosomes decoding mRNA on a hepta-nucleotides slippery sequence (XXXYYYZ) followed by an optimally spaced stimulator pseudoknot. These signals on mRNA cause a fraction of ribosomes to shift into the -1 reading-frame. A co-translational refolding hairpin found in upstream of slippery sequence attenuates the stimulator pseudoknot-mediated -1 PRF efficiency, and was named “attenuator”. Riboswitch, structured RNA capable

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16

Kuo, Tai-Chin, and 郭黛瑾. "Regulation of -1 programmed ribosomal frameshifting in trans by small single-stranded RNA." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/90612600237412879376.

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碩士<br>國立中興大學<br>生物化學研究所<br>98<br>The mechanism for the induction of −1 programmed ribosomal frameshifting(-1 PRF) requires two major elements: a heptanucleotide slippery site and a downstream RNA pseudoknot structure connected by a spacer. It has been demonstrated that RNA pseudoknot, hTPK-DU177 (DU177), which is derived from human telomerase RNA, can induce the -1 PRF efficiency of 50%. When the specific base-triple of DU177 was mutated to disrupt the interaction of base-triple, the efficiency of -1 PRF was seriously impaired even if the DU177 still adopts a pseudoknot conformation. Therefore

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17

Yang, Zih-Liang, and 楊子諒. "Regulation of -1 Programmed Ribosomal Frameshifting by an S-adenosylmethionine-responsive RNA pseudoknot." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/48225291165311531880.

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碩士<br>國立中興大學<br>生物化學研究所<br>104<br>During translation, ribosome is responsible for reading-frame maintenance to guarantee codons translated into amino acids in correct order and folded into functional proteins. However, some speciﬁc signals within mRNAs can induce a fraction of elongating ribosomes to move one base backward in the 5’ direction, and resume elongating on the -1 reading frame, which would produce different protein product from the 0-frame encoded protein. This event is called -1 programmed ribosomal frameshifting (-1 PRF). An efficient -1 PRF signal within mRNAs requires two eleme

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18

Chang, Hui-Ting, and 張惠婷. "Effect of spacer-length on -1 programmed ribosomal frameshifting of different stimulator RNAs." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/53165089815237730925.

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碩士<br>國立中興大學<br>生物化學研究所<br>103<br>Ribosome decodes the reading frame of messenger RNA (mRNA) to synthesize protein during translation. However, the mRNAs contain the signasl that are sufficient to cause -1 programmed ribosomal frameshifting (-1PRF). The signals include a hepta-nucleotide slippery site, a stimulator RNA structure, and a proper spacer distance. According to the -1PRF model, frameshifting could occur during the accommodation of aminoacyl-tRNA into the A-site or translocation stage of a translation elongation cycle. When the elongating ribosome encounters the stable and complicate

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19

Chou, Ming-Yuan, and 周銘源. "The important structural features of the DU177 RNA pseudoknot in stimulating programmed -1 ribosomal frameshifting." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/58425338942445395540.

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博士<br>國立中興大學<br>生物化學研究所<br>98<br>Programmed -1 ribosomal frameshifting (-1 PRF), which is known to be caused by the slippery sequence and the stimulator sequence, modulates the moving direction and distance of a translating ribosome. Upon reaching the slippery sequence, the translation complex tends to shift into the -1 reading frame. However, the tRNAs in the translation complex can still form stable codon-anticodon interactions after shifting into the -1 frame because of the composition of the slippery sequence. The stimulator sequence, properly distant from the slippery sequence, is regarde

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20

Gupta, Asmita. "In Silico Perspectives on RNA Structures Modulating Viral Gene Expression and Mechanics of tRNA Transport." Thesis, 2015. http://etd.iisc.ernet.in/2005/3864.

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The repertoire of cellular functions mediated by Ribonucleic acid (RNA) molecules have expanded considerably during the last two decades. The role played by RNA in controlling and regulating gene expression in viruses, prokaryotes and eukaryotes has been a matter of continuous investigations. This interest has arisen primarily due to the discoveries of cisacting RNA structures like riboswitches, ribosensors and frameshift elements, which are found in either the 5’-, 3’-untranslated regions of mRNA or in the open reading frames. These structures control gene expression at the level of

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