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1

Macknight, J. M. "PROGRESSIVE WEAKNESS- WEIGHTLIFTER." Medicine & Science in Sports & Exercise 30, Supplement (1998): 132. http://dx.doi.org/10.1097/00005768-199805001-00748.

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2

Carswell, Christopher, Luke C. Northey, Leo Davies, Nobuhiro Yuki, and Matthew C. Kiernan. "Progressive bilateral facial weakness." Practical Neurology 15, no. 1 (2014): 76–79. http://dx.doi.org/10.1136/practneurol-2014-000989.

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3

Galloway, Gloria, Michael J. Giuliani, and David Lacomis. "October 1996 — Rapidly Progressive Weakness." Brain Pathology 7, no. 2 (1997): 837–38. http://dx.doi.org/10.1111/j.1750-3639.1997.tb01068.x.

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4

Navalkele, Digvijaya D., Maria-Magdalena Georgescu, Dennis K. Burns, Tasha Greenberg, and Steven Vernino. "Progressive Leg Pain and Weakness." JAMA Neurology 70, no. 4 (2013): 510. http://dx.doi.org/10.1001/jamaneurol.2013.2158.

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5

Lewis, D. W., and P. H. Berman. "Progressive Weakness in Infancy and Childhood." Pediatrics in Review 8, no. 7 (1987): 200–208. http://dx.doi.org/10.1542/pir.8-7-200.

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6

Sim, Li Ean, and Kevin Tan. "Progressive Weakness, Cognitive Dysfunction and Seizures." Annals of the Academy of Medicine, Singapore 45, no. 7 (2016): 330–31. http://dx.doi.org/10.47102/annals-acadmedsg.v45n7p330.

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7

Lewis, Donald W., and Peter H. Berman. "Progressive Weakness in Infancy and Childhood." Pediatrics In Review 8, no. 7 (1987): 200–208. http://dx.doi.org/10.1542/pir.8.7.200.

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The child with progressive weakness may have a disorder at one of many possible levels within the nervous system. By establishing the pace and character of the weakness and by localizing the anatomic site of the pathologic condition to either the upper or the lower motor neuron unit, a scheme for systematic evaluation can be developed.
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8

Younger, David. "Differential Diagnosis of Progressive Flaccid Weakness." Seminars in Neurology 13, no. 03 (1993): 241–46. http://dx.doi.org/10.1055/s-2008-1041130.

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9

Asbill, Mark C., and Randolph B. Shey. "Progressive Back Pain and Leg Weakness." Hospital Practice 25, sup5 (1990): 132–35. http://dx.doi.org/10.1080/21548331.1990.11704118.

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10

Lakhotia, Arpita. "A Child With Progressive Leg Weakness." Pediatric Neurology 74 (September 2017): 104–5. http://dx.doi.org/10.1016/j.pediatrneurol.2017.05.001.

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11

Ora, Manish, LokeshwaranMadurai Kalimuthu, Prakash Singh, and Sanjay Gambhir. "Rib plasmacytoma presenting as progressive muscle weakness." Indian Journal of Nuclear Medicine 36, no. 1 (2021): 66. http://dx.doi.org/10.4103/ijnm.ijnm_133_20.

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12

Felice, K., U. DeGirolami, and D. A. "Pyomyositis presenting as rapidly progressive generalized weakness." Neurology 41, no. 6 (1991): 944. http://dx.doi.org/10.1212/wnl.41.6.944.

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13

Ferrer, Isidro, Fina Climent, Noemi Vidal, Luis Alberto Escobar, Juan José Sánchez, and Alejandro Fernandez-Coello. "74 Year-Old Woman with Progressive Weakness." Brain Pathology 26, no. 3 (2016): 423–24. http://dx.doi.org/10.1111/bpa.12380.

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14

Shannon, Robert P., H. Gordon Deen, and Stephen D. Trigg. "Rapidly Progressive Weakness in an Elderly Golfer." Medicine & Science in Sports & Exercise 39, Supplement (2007): S106—S107. http://dx.doi.org/10.1249/01.mss.0000273340.26113.cb.

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15

Seemann, Natashia, Craig Campbell, Robert Hammond, and Chitra Prasad. "9 YEAR OLD GIRL WITH PROGRESSIVE WEAKNESS." Brain Pathology 20, no. 1 (2010): 255–56. http://dx.doi.org/10.1111/j.1750-3639.2009.00344.x.

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16

Hirji, Sameer A., Manish M. Karamchandani, Jonathan W. Scott, and Matthew T. Menard. "Spontaneous Progressive Muscle Weakness with Persistent Leukocytosis." Case Reports in Surgery 2019 (July 9, 2019): 1–4. http://dx.doi.org/10.1155/2019/7085219.

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Iliacus compartment syndrome is a rare clinical condition which can result in a severe, unilateral, femoral neuropraxia. Recognition of this syndrome as the cause of a developing neuropathy is often delayed given a lack of familiarity with this clinical diagnosis and the retroperitoneal location of the iliacus muscle. Prompt diagnosis is important to avoid risk of consequent muscle necrosis, rhabdomyolysis, and possibly permanent nerve injury. We describe a case of iliacus compartment syndrome in an elderly, frail woman with end-stage renal disease, anticoagulated for atrial fibrillation, who
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17

Kim, Soo Yeon, Jung Min Ko, Sun Ah Choi, et al. "A 3‐Month‐Old Boy With Progressive Weakness." Brain Pathology 28, no. 5 (2018): 773–74. http://dx.doi.org/10.1111/bpa.12651.

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18

Gitiaux, Cyril, Jean Bergounioux, Maryse Magen, et al. "Diaphragmatic Weakness With Progressive Sensory and Motor Polyneuropathy." Journal of Child Neurology 28, no. 6 (2012): 787–90. http://dx.doi.org/10.1177/0883073812450209.

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19

Stibb, Stacy, Mark E. Gormley, and Nanette Aldahondo. "Progressive Weakness and Optic Atrophy: A Case Report." PM&R 5 (September 2013): S201—S202. http://dx.doi.org/10.1016/j.pmrj.2013.08.283.

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20

Sankhyan, Naveen, Suvasini Sharma, Anita Choudhary, et al. "Progressive weakness in a 12-year-old boy." Journal of Clinical Neuroscience 18, no. 12 (2011): 1686. http://dx.doi.org/10.1016/j.jocn.2010.07.134.

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21

Sankhyan, Naveen, Suvasini Sharma, Anita Choudhary, et al. "Progressive weakness in a 12-year-old boy." Journal of Clinical Neuroscience 18, no. 12 (2011): 1751. http://dx.doi.org/10.1016/j.jocn.2010.07.138.

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22

van der Meulen, M. "A man with progressive weakness in his legs." Lancet 354, no. 9185 (1999): 830. http://dx.doi.org/10.1016/s0140-6736(99)03395-4.

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23

van der Meulen, MFG, GJE Rinkel, Th D. Witkamp, and J. van Gijn. "A man with progressive weakness in his legs." Lancet 354, no. 9181 (1999): 830. http://dx.doi.org/10.1016/s0140-6736(99)80014-2.

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24

Nahari, Yafit, Ahmed Abbas, Elizabeth Curtis, and Saiju Jacob. "Slowly progressive distal muscle weakness: neuropathy or myopathy?" BMJ Case Reports 12, no. 4 (2019): e226903. http://dx.doi.org/10.1136/bcr-2018-226903.

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Nonaka myopathy is an autosomal recessive and slowly progressive distal myopathy. It is part of a rare group of myopathies predominantly affecting the distal limb musculature. Over 150 cases have been reported across the Middle East, Japan and Europe. We report the case of a 33-year-old woman presenting with symmetrical upper and lower limb weakness, most severely affecting the distal muscle groups. After extensive neurological investigation including neurophysiology, muscle biopsy and genetic analysis, she was finally diagnosed with Nonaka myopathy and treated conservatively with physiotherap
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25

Nagpal, Tuhina, Kamlesh Agrawal, Ashok Gupta, and Priyanshu Mathur. "Spinal muscular atrophy with progressive myoclonic epilepsy - rare case report from India." International Journal of Contemporary Pediatrics 8, no. 2 (2021): 381. http://dx.doi.org/10.18203/2349-3291.ijcp20210134.

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Spinal muscular atrophy with progressive myoclonic epilepsy is a rare genetic disorder characterized by progressive muscular weakness and myoclonic seizures. Herein we report an Indian boy with myoclonic seizures followed by progressive weakness of both lower limbs and detected with heterozygous mutation in N-acylsphingosine amidohydrolase 1 (ASAH1) gene causing spinal muscular atrophy with progressive myoclonic epilepsy.
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26

Al Kaissi, Ali, Sergey Ryabykh, Polina Ochirova, et al. "Muscle Weakness." Journal of Investigative Medicine High Impact Case Reports 5, no. 1 (2017): 232470961668958. http://dx.doi.org/10.1177/2324709616689583.

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Marked ligamentous hyperlaxity and muscle weakness/wasting associated with awkward gait are the main deficits confused with the diagnosis of myopathy. Seven children (6 boys and 1 girl with an average age of 8 years) were referred to our department because of diverse forms of skeletal abnormalities. No definitive diagnosis was made, and all underwent a series of sophisticated investigations in other institutes in favor of myopathy. We applied our methodology through the clinical and radiographic phenotypes followed by targeted genotypic confirmation. Three children (2 boys and 1 girl) were com
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27

Jain, Shalabh, Siddharth Yadav, Swarna Gupta, and Ritu Gupta. "Bimelic Hirayama Disease: Clinical Dilemma Solved by Imaging." Case Reports in Medicine 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/606894.

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Hirayama disease (juvenile muscular atrophy of distal upper extremity) is a cervical myelopathy predominantly affecting adolescent males. It is characterized by progressive muscular weakness and atrophy of unilateral or asymmetrically bilateral distal upper limbs. We report a case of an 18-year-male painter, who presented with gradually progressive, symmetrical bilateral weakness of hands and forearm for the last two years. On the basis of clinical examination, a provisional diagnosis of lower motor neuron type of symmetrical distal weakness due to heavy metal intoxication was kept. However, i
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28

Mueller, Sandro Manuel, Jacques Emanuel Schaefer, Tibor Hortobagyi, and Robert Thurnheer. "Muscle weakness with a hidden cause." BMJ Case Reports 18, no. 5 (2025): e263689. https://doi.org/10.1136/bcr-2024-263689.

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Idiopathic inflammatory myopathies (IIM) represent a diverse group of systemic autoimmune disorders characterised by skeletal muscle weakness with variable clinical manifestations.Dermatomyositis (DM) is a heterogeneous IIM and is associated with progressive muscle weakness, with characteristic skin features, and with an increased risk of malignancy. Here, we report a previously healthy man in his early 40s who presented to the emergency department with a 14-day history of symmetric progressive proximal muscle weakness. Both upper arms were painful and swollen, and they displayed marked weakne
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29

Weisleder, Pedro, and Addie Hunnicutt. "A teenager with progressive lower extremity weakness and pain." Journal of Pediatric Neurosciences 3, no. 2 (2008): 172. http://dx.doi.org/10.4103/1817-1745.43653.

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30

Murali, Sathiya, Arpana Shekhar, S. Shyam Sudhakar, Kiran Natarajan, and Mohan Kameswaran. "Unilateral internal auditory canal stenosis with progressive facial weakness." Bangladesh Journal of Otorhinolaryngology 18, no. 2 (2012): 179–82. http://dx.doi.org/10.3329/bjo.v18i2.12014.

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Internal auditory canal (IAC) stenosis is a rare cause of sensorineural hearing loss. Patient may present with symptoms of progressive facial nerve palsy, hearing loss, tinnitus and giddiness. High resolution temporal bone CT-scan and magnetic resonance imaging (MRI) are the important tools for diagnosis. No specific management has been devised. Here is presentation of a case of unilateral (left) IAC stenosis with profound hearing loss and progressive House Brackmann Grade III-IV facial weakness. The diameter of the IAC was less than 2 mm on high resolution temporal bone computed tomography (H
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31

Attreed, N. J., and S. A. Shields. "A woman with rapidly progressive weakness and sensory loss." BMJ 343, dec21 1 (2011): d7845. http://dx.doi.org/10.1136/bmj.d7845.

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32

Gómez de la Torre, Ricardo, María Folgueras Gómez, Lourdes Sánchez Miranda, Ariana Fonseca Mourelle, Iván Fernández Vega, and Germán Moris de la Tassa. "GOOD SYNDROME PRESENTING WITH PROGRESSIVE MUSCLE WEAKNESS FOLLOWING THYMECTOMY." Archivos de Patologia 4, no. 3 (2025): 4–9. https://doi.org/10.17811/ap.v4i3.22228.

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We present the case of a patient with Good syndrome who developed progressive muscle weakness following thymectomy. Muscle biopsy revealed criteria consistent with inclusion body myositis. Throughout her illness, she developed pure red cell aplasia, respiratory failure, and recurrent respiratory infections. She was treated with intravenous immunoglobulins, pyridostigmine, and cyclosporine A, achieving stability in her hematologic condition but without improvement in her myopathic symptoms. This case highlights the potential role of the thymus in the pathogenesis of autoimmune manifestations.
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33

Mah, Jean K., and Harvey B. Sarnat. "A 10-Year-Old Girl with Progressive Generalized Weakness." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 33, no. 4 (2006): 414–17. http://dx.doi.org/10.1017/s0317167100005394.

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Case PresentationDr. Harvey Sarnat: A.Y. was a 10-year-old Mexican girl who presented with a 7-year history of progressive weakness. She was the full-term product of an uncomplicated pregnancy and delivery, weighing 2850 grams at birth. Early developmental milestones were achieved at the expected rate until age three, when frequent falling was noted. Progressive weakness of her legs ensued, and at age nine years, A.Y. lost the ability to walk beyond a few steps, and shortly thereafter she could not stand without support. She had no seizures, visual disturbance, dysphagia, or incontinence. Prev
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34

Kim, Janet B., and Mark Ballow. "Progressive muscle weakness in a 4-year-old girl." Annals of Allergy, Asthma & Immunology 92, no. 1 (2004): 19–24. http://dx.doi.org/10.1016/s1081-1206(10)61705-x.

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35

Cho, Janice M., and Chris A. Aakre. "69-Year-Old Woman With Progressive Weakness and Anorexia." Mayo Clinic Proceedings 94, no. 9 (2019): 1879–82. http://dx.doi.org/10.1016/j.mayocp.2019.02.031.

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36

ALBASHIR, S., L. OLANSKY, and M. SASIDHAR. "Progressive muscle weakness: More there than meets the eye." Cleveland Clinic Journal of Medicine 78, no. 6 (2011): 385–91. http://dx.doi.org/10.3949/ccjm.78a.10116.

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37

Mangels, Kyle J., Mahlon D. Johnson, and Robert J. Weil. "35-year-old Woman with Progressive Bilateral Leg Weakness." Brain Pathology 16, no. 2 (2006): 183–84. http://dx.doi.org/10.1111/j.1750-3639.2006.00003_2.x.

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38

Sinha, U. K. "Visual disturbance in a patient with progressive limb weakness." Postgraduate Medical Journal 77, no. 909 (2001): 1e—1. http://dx.doi.org/10.1136/pmj.77.909.e1.

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39

Mahmoud, Kamala, Domnick D'costa, and Sue Dorrian. "A case of recurrent rapidly progressive lower limb weakness." Age and Ageing 37, no. 4 (2008): 383. http://dx.doi.org/10.1093/ageing/afn104.

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40

Hilton, David A., and Brendan McLean. "December 2001: Rapidly progressive motor weakness, starting in pregnancy." Brain Pathology 12, no. 2 (2002): 267–69. http://dx.doi.org/10.1111/j.1750-3639.2002.tb01094.x.

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AbstractCases of the Month, October–December 2001The October Case of the Month (COM). A 40‐year‐old Xhosa male presented with progressive upper lumbar back pain and weakness At examination he was emaciated and had enlarged lymph nodes in the groin and axilla. Both lower limbs were severely atrophic and weak. Sensation to touch and pain was decreased below L3 bilaterally. MR of the spine showed a discrete, contrast‐enhancing epidural mass. A T10–T12 laminectomy revealed an soft, vascular extradural tumor dorsal to the cord. The mass was loosely applied to the dura and easy to remove. The operat
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41

Widjajanti, Anik, and S. M. Agustini. "HIPOKALEMIK PERIODIK PARALISIS." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 12, no. 1 (2018): 19. http://dx.doi.org/10.24293/ijcpml.v12i1.836.

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A 7-year-old boy of Java origin, visited the doctor with progressive weakness everytime he ate food containing Monosodium Glutamat (MSG). Progressive weakness began from his legs and spreaded to the arms as well (sometimes also to the neck). He could neither walk nor do anything for 5–6 hours then began to resolve spontaneously.. We suspected the diagnosis of hypokalaemic periodic paralysis upon the history of episodes of flacid paralysis and low serum concentration of potassium (< 3,5 mmol/L) during the attacts. The clinical examination showed that this boy is in good general and nutrition
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42

Alshamali, Sara, Jana Alanati, and Alessandro Terruzzi. "Solitary Sclerosis Presenting as Progressive Brainstem Symptoms." Journal of Clinical Case Studies Reviews & Reports 5, no. 12 (2023): 1–6. http://dx.doi.org/10.47363/jccsr/2023(5)266.

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A woman in her 30s, presented with left facial weakness, left eyelid droop, left gaze diplopia as well as right facial and upper limb numbness; which progressively worsened over 1 month. She also developed dizziness, dysphonia, dysphagia, and an imbalanced gait. On exam, she had hoarseness, dysarthria, anisocoria; left pupil miosis, left eyelid ptosis, left gaze diplopia, left lower face weakness, deviation of the palate and uvula towards the left side, right eye nystagmus, right sided facial numbness, right upper limb numbness, right dysmetria, brisk reflexes all-over and an unsteady gait. Th
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43

Sunil, Kumar Agarwalla* &. Nasreen Ali. "HEREDITARY MOTOR AND SENSORY NEUROPATHY (HMSN) DISEASE -IN TWO SIBLINGS." Indian Journal of Medical Research and Pharmaceutical Sciences 4, no. 12 (2017): 1–4. https://doi.org/10.5281/zenodo.1095885.

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Hereditary motor sensory neuropathy (HMSN), also known as Charcot-Marie-Tooth Disease, is an inherited, progressive disease of the nerves with weakness and numbness more pronounced in the legs than the arms. Parts of the nerve cells deteriorate. The muscles in the hands and feet get weak because they no longer receive normal impulses from the nerves, and therefore are not being used adequately. Symptoms vary greatly. In addition to muscle weakness, there can be fatigue, pain, numbness, lack of balance, sight and hearing. There can be high arched feet, hammer toes, foot drop, and foot defo
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44

Tsai, Yu-Chieh, Hui-Chu Tsai, and Wei-Jing Lee. "Woman with left-side weakness." Hong Kong Journal of Emergency Medicine 26, no. 1 (2018): 65–66. http://dx.doi.org/10.1177/1024907918804428.

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Most acute intracranial hemorrhages present to the emergency department are due to severe hypertension, coagulopathies, aneurysm, or tumor. We describe a 41-year-old female presented with progressive left-side weakness for 6 h. Initial computed tomography of the brain showed acute hemorrhage at right temporo-parietal region. Subsequent brain magnetic resonance imaging confirmed right cerebral cortical venous thrombosis complicated by acute intraparenchymal hematoma. This report provides a rare etiology of acute intracranial hemorrhage in which early diagnosis and prompt anticoagulation are cru
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45

Mohan, Nidin, Dayanandan Yoganandan, Kavitha Mohanasundaram, Kandasamy V. Rajalakshmi, and S. Magesh Kumar. "Rapidly progressing treatment resistant anti-TIF1 gamma antibody positive dermatomyositis." International Journal of Advances in Medicine 9, no. 3 (2022): 342. http://dx.doi.org/10.18203/2349-3933.ijam20220358.

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Dermatomyositis is an idiopathic inflammatory myositis involving progressive muscle weakness with skin manifestations. Incidence of dermatomyositis is 1 per 100,000 in general population. Diagnosis is based on characteristic skin rashes, progressive muscle weakness and elevated muscle enzymes levels (creatine phosphokinase). The diagnosis is confirmed by clinical examination, abnormal electromyogram and autoimmune workup. In this case report, we report a case of difficult to treat dermatomyositis with proximal muscle weakness in an elderly male patient with classical skin lesions. The patient
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46

Varatharajan, Aaran. "Acute Guillain-Barré Syndrome After Sacroiliac Joint Fusion." Pain Medicine Case Reports 8, no. 4 (2024): 137–42. http://dx.doi.org/10.36076/pmcr.2024.8.137.

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BACKGROUND: Guillain-Barré syndrome (GBS), also called acute inflammatory demyelinating polyradiculopathy (AIDP), is one of the most common causes of acute, acquired weaknesses. GBS is an acute immune-mediated polyneuropathy that presents with progressive weakness of the arms or legs. GBS presents after infection; however, there are few reports that describe acute GBS after chronic pain procedures. CASE REPORT: A 70-year-old man with a past medical history of spinal stenosis status post anterior cervical discectomy and fusion, sacroiliac joint (SIJ) dysfunction status post SIJ fusion presented
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47

Ciliberti, Eric F., and Richard A. Prayson. "Pathologic Quiz Case: Male With Chronic Progressive Painless Muscle Weakness." Archives of Pathology & Laboratory Medicine 126, no. 1 (2002): 105–6. http://dx.doi.org/10.5858/2002-126-0105-pqcmwc.

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48

BUI, ANDREW, and SHARONYA SHRIVASTAVA. "PROGRESSIVE ASCENDING WEAKNESS AFTER THE PFIZER/BIONTECH COVID-19 VACCINE." Chest 162, no. 4 (2022): A69. http://dx.doi.org/10.1016/j.chest.2022.08.042.

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49

Mansoor, Simin, and Tulio E. Bertorini. "A Male With Progressive Lower Extremity Weakness and Monoclonal Gammopathy." Journal of Clinical Neuromuscular Disease 14, no. 4 (2013): 194–203. http://dx.doi.org/10.1097/cnd.0b013e31829081cc.

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50

Anderson, Eric R., Jonathan D. Glass, and James G. Greene. "A 61-Year-Old Woman With Progressive Weakness and Rash." Neurohospitalist 2, no. 2 (2012): 62–65. http://dx.doi.org/10.1177/1941874411435174.

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