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1

Johnson, Brett A., Cynthia C. Woo, Yu Zeng, Zhe Xu, Edna E. Hingco, Joan Ong, and Michael Leon. "Prolonged stimulus exposure reveals prolonged neurobehavioral response patterns." Journal of Comparative Neurology 518, no. 10 (May 15, 2010): 1617–29. http://dx.doi.org/10.1002/cne.22299.

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2

Underwood, Elizabeth L., JoLeigh Sutton, Ira Keith Ellis, Brian Qualls, Jon Zamber, and Brian N. Walker. "Prolonged coagulopathy after brodifacoum exposure." American Journal of Health-System Pharmacy 71, no. 8 (April 15, 2014): 639–42. http://dx.doi.org/10.2146/ajhp130537.

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3

Oprel, Danielle A. C., Chris M. Hoeboer, Maartje Schoorl, Rianne A. de Kleine, Marylene Cloitre, Ingrid G. Wigard, Agnes van Minnen, and Willem van der Does. "Effect of Prolonged Exposure, intensified Prolonged Exposure and STAIR+Prolonged Exposure in patients with PTSD related to childhood abuse: a randomized controlled trial." European Journal of Psychotraumatology 12, no. 1 (January 1, 2021): 1851511. http://dx.doi.org/10.1080/20008198.2020.1851511.

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4

WACHTER, KERRI. "Prolonged Exposure Therapy Lessens PTSD Symptoms." Clinical Psychiatry News 34, no. 2 (February 2006): 26. http://dx.doi.org/10.1016/s0270-6644(06)71163-8.

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Budeyri Gokgoz, Nilay, Fatma Gizem Avci, Kubra Karaosmanoglu Yoneten, Begum Alaybeyoglu, Elif Ozkirimli, Nihat Alpagu Sayar, Dilek Kazan, and Berna Sariyar Akbulut. "Response ofEscherichia colito Prolonged Berberine Exposure." Microbial Drug Resistance 23, no. 5 (July 2017): 531–44. http://dx.doi.org/10.1089/mdr.2016.0063.

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6

Kanariou, M., E. Petridou, E. Vrachnou, and D. Trichopoulos. "Lymphocyte alterations after prolonged sunlight exposure." Journal of Epidemiology and Biostatistics 6, no. 6 (November 1, 2001): 463–65. http://dx.doi.org/10.1080/135952201317225499.

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7

Salvadego, Desy, Michail E. Keramidas, Roger Kölegård, Irene Mavelli, Ola Eiken, Igor B. Mekjavic, and Bruno Grassi. "Prolonged Exposure to Hypoxia and Microgravity." Medicine & Science in Sports & Exercise 47 (May 2015): 220. http://dx.doi.org/10.1249/01.mss.0000477027.00901.ee.

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8

Steenkamp, Maria M., and Brett T. Litz. "Prolonged Exposure Therapy in Veterans Affairs." JAMA Psychiatry 71, no. 2 (February 1, 2014): 211. http://dx.doi.org/10.1001/jamapsychiatry.2013.3305.

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9

Feirer, Nicola, Christian Honemann, and Marcel Durieux. "PROLONGED BUPIVACAINE EXPOSURE INHIBITS BLOOD COAGULATION." Anesthesiology 89, Supplement (September 1998): 836A. http://dx.doi.org/10.1097/00000542-199809150-00011.

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10

Ushakov, I. B., and V. P. Fedorov. "The neuromorphological correlates of prolonged radiation exposure." Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations, no. 3 (September 28, 2018): 86–97. http://dx.doi.org/10.25016/2541-7487-2018-0-3-86-97.

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Relevance.Liquidators of the consequences of radiation accidents have an increase in neuropsychiatric diseases. However, the structural and functional rearrangement of brain neurons under prolonged low radiation exposure remains virtually unexplored, which makes it difficult to assess the pathogenesis of these diseases.Intention.To study morphological correlates of prolonged low radiation effects on brain neurons in the model of radiobiological experiment.Method.270 white outbred male rats aged 4 months were exposed to radiation-quanta of 60Co in equal portions in total doses of 10; 20; 50 and 100 cGy with a dose rate of 0.5 Gy/h over 5 days. Age control consisted of animals exposed to false radiation. Animal studies complied with GLP standards. Brain fragments were taken after 1 day, 6, 12, 18 and 24 months after irradiation. After a standard histological treatment, changes in the tinctorial properties of neurons, their morphometric parameters, total protein and nucleic acids were evaluated.Results and their analysis. At the end of the observation period, the number of normochromic neurons decreased and the number of hyper and hypochromic cells increased, as well as their destructive forms. The neuro-cellular index decreased over time suggesting the death of some neurons, but without a statistically significant decrease in their number per area. In the post-irradiation period there were observed phase changes in the size of the cytoplasm, nucleus and nucleolus of neurons, as well as the content of protein and nucleic acids (RNA in the cytoplasm and nucleoli, DNA in the nuclei), more pronounced in irradiated animals and sometimes different from those observed in age control animals. As a result, a number of neuromorphological parameters in some periods of observation were not consistent with those in control animals, with a certain instability in the structural and functional organization of neurons.Conclusion.Prolonged low-dose ionizing radiation does not cause significant organic changes in the brain. However, increased radiation exposure or other concomitant adverse factors can be associated with further instability of the structural and functional organization of neurons and serve as a material substrate for a number of deviations in the central nervous system.
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11

Hughey, Scott B., Kari L. McCoy, and Aaron E. Mills. "Prolonged Brackish Water Exposure: A Case Report." Wilderness & Environmental Medicine 31, no. 3 (September 2020): 324–26. http://dx.doi.org/10.1016/j.wem.2020.04.003.

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12

Gilboa-Schechtman, E. "Prolonged exposure therapy for adolescents with PTSD." Neuropsychiatrie de l'Enfance et de l'Adolescence 60, no. 5 (July 2012): S112. http://dx.doi.org/10.1016/j.neurenf.2012.05.474.

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13

Folinsbee, L. J., D. H. Horstman, and W. F. McDonnell. "PROLONGED EXERCISE DURING LOW LEVEL OZONE EXPOSURE." Medicine and Science in Sports and Exercise 21, Supplement (April 1989): S73. http://dx.doi.org/10.1249/00005768-198904001-00437.

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14

Mikhailets, N. D., M. I. Balabolkin, V. A. Rakitin, and I. P. Danilov. "Thyroid function during prolonged exposure to fluorides." Problems of Endocrinology 42, no. 1 (February 15, 1996): 6–9. http://dx.doi.org/10.14341/probl11890.

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Thyroid function was examined in 165 workers of electrolysis shops of aluminum production with more or less expressed signs of chronic fluoride intoxication (fluorosis) by radioimmunoassay of hormones and the test of 13II absorption by the thyroid. The detected thyroid abnormalities were characterized by a moderate reduction of iodine-absorbing function of the thyroid, low T3 with normal T4 level, and a slight increase of TTH concentration. These changes augmented with longer service and fluorosis progress. Hence, the syndrome of low T3 and reduced absorption of 1311 may be considered as diagnostic signs of fluorosis. In case of toxic involvement of the liver in fluorosis patients, low T3 syndrome is observed much more frequently: in 75.6% cases. Liver abnormalities evidently lead to disorders in the peripheral conversion of T4 in T3, occurring primarily in liver parenchyma. Indirect effect of fluorine on the enzymatic system of deiodination cannot be ruled out as well.
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15

Levin, Aaron. "Prolonged Exposure Therapy Helps Ward off PTSD." Psychiatric News 43, no. 13 (July 4, 2008): 13. http://dx.doi.org/10.1176/pn.43.13.0013a.

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16

Valentin, J. "A. Annex A: some prolonged exposure situations." Annals of the ICRP 29, no. 1-2 (March 1999): 71–79. http://dx.doi.org/10.1016/s0146-6453(00)00017-8.

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17

Ma, H., H. Almutairi, L. Lavoie, M. D. Iafrati, and N. A. Rosen. "Prolonged Radiation Exposure in IVC Filter Removal." Journal of Vascular Surgery: Venous and Lymphatic Disorders 1, no. 1 (January 2013): 103–4. http://dx.doi.org/10.1016/j.jvsv.2012.10.017.

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18

Hembree, Elizabeth A. "The Case: Treating Jared Through Prolonged Exposure." Journal of Clinical Psychology 69, no. 5 (April 16, 2013): 485–87. http://dx.doi.org/10.1002/jclp.21983.

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19

Price, T. J., and L. Nott. "Unusual hair changes with prolonged erlotinib exposure." Internal Medicine Journal 38, no. 10 (October 2008): 807. http://dx.doi.org/10.1111/j.1445-5994.2008.01781.x.

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20

Chiriboga, Claudia A., Denise Starr, Louise Kuhn, and Gail A. Wasserman. "Prenatal Cocaine Exposure and Prolonged Focus Attention." Developmental Neuroscience 31, no. 1-2 (2009): 149–58. http://dx.doi.org/10.1159/000207502.

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21

Sarwal, Amara, and Isaiarasi Gnanasekaran. "Hydralazine induced lupus nephritis after prolonged exposure." American Journal of the Medical Sciences 361, no. 1 (January 2021): 130–31. http://dx.doi.org/10.1016/j.amjms.2020.07.007.

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22

Kim, Sohyun, Istvan Kovanecz, Gonzalez-Cadavid Nestor, and Sheryl L. Chow. "Ventricular Fibrosis from Prolonged Bisphenol A Exposure." Journal of Cardiac Failure 20, no. 8 (August 2014): S22. http://dx.doi.org/10.1016/j.cardfail.2014.06.064.

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23

Ichikawa, Takeshi, Hiroko Sato, Kyoichi Kaira, Shinsuke Oh-I, Satoru Kakizaki, Ken Sato, Hitoshi Takagi, and Masatomo Mori. "Prolonged intrahepatic cholestasis after exposure to loxoprofen." Clinical Therapeutics 30, no. 12 (December 2008): 2402–6. http://dx.doi.org/10.1016/j.clinthera.2008.12.012.

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24

Foa, Edna B. "Prolonged exposure therapy: past, present, and future." Depression and Anxiety 28, no. 12 (December 2011): 1043–47. http://dx.doi.org/10.1002/da.20907.

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25

Ing, Caleb, Xiaoyue Ma, Anna J. Klausner, Richard P. Dutton, and Guohua Li. "Prolonged Anesthetic Exposure in Children and Factors Associated With Exposure Duration." Journal of Neurosurgical Anesthesiology 31, no. 1 (January 2019): 134–39. http://dx.doi.org/10.1097/ana.0000000000000540.

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26

Ghaedi, Behnaz, and Nigel R. Andrew. "The physiological consequences of varied heat exposure events in adultMyzus persicae: a single prolonged exposure compared to repeated shorter exposures." PeerJ 4 (August 2, 2016): e2290. http://dx.doi.org/10.7717/peerj.2290.

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The study of environmental stress tolerance in aphids has primarily been at low temperatures. In these cases, and in the rare cases of high temperature tolerance assessments, all exposures had been during a single stress event. In the present study, we examined the physiological consequences of repeated high temperature exposure with recovery periods between these stress events inMyzus persicae. We subjected individuals to either a single prolonged three hour heating event, or three one hour heating events with a recovery time of 24 h between bouts. Aphids exposed to repeated bouts of high temperatures had more glucose and higher expression of proteins and osmolyte compounds, such as glycerol, compared to the prolonged exposure group. However, aphids exposed to the repeated high temperature treatment had reduced sources of energy such as trehalose and triglyceride compounds than the prolonged exposure group. Recovery time had more physiological costs (based on production of more protein and consumption of more trehalose and triglyceride) and benefits (based on production of more osmolytes) in repeated high temperature treatments. As aphids are known to respond differently to constant versus ‘natural’ fluctuating temperature regimes, conclusions drawn from constant temperature data sets may be problematic. We suggest future experiments assessing insect responses to thermal stress incorporate a repeated stress and recovery pattern into their methodologies.
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27

Flora, Darcy R., and Lincoln R. Potter. "Prolonged Atrial Natriuretic Peptide Exposure Stimulates Guanylyl Cyclase-A Degradation." Endocrinology 151, no. 6 (April 9, 2010): 2769–76. http://dx.doi.org/10.1210/en.2009-1239.

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Natriuretic peptide receptor-A (NPR-A), also known as guanylyl cyclase-A, is a transmembrane receptor guanylyl cyclase that is activated by the cardiac hormones atrial natriuretic peptide and B-type natriuretic peptide. Although ligand-dependent NPR-A degradation (also known as down-regulation) is widely acknowledged in human and animal models of volume overload, down-regulation in cultured cells is controversial. Here, we examined the effect of ANP exposure on cellular NPR-A levels as a function of time. Relative receptor concentrations were estimated using guanylyl cyclase and immunoblot assays in a wide variety of cell lines that endogenously or exogenously expressed low or high numbers of receptors. ANP exposures of 1 h markedly reduced hormone-dependent but not detergent-dependent guanylyl cyclase activities in membranes from exposed cells. However, 1-h ANP exposures did not significantly reduce NPR-A concentrations in any cell line. In contrast, exposures of greater than 1 h reduced receptor concentrations in a time-dependent manner. The time required for half of the receptors to be degraded (t1/2) in primary bovine aortic endothelial and immortalized HeLa cells was approximately 8 h. In contrast, a 24-h exposure of ANP to 293T cells stably overexpressing NPR-A caused less than half of the receptors to be degraded. To our knowledge, this is the first report to directly measure NPR-A down-regulation in endogenously expressing cells. We conclude that down-regulation is a universal property of NPR-A but is relatively slow and varies with receptor expression levels and cell type.
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28

Giannouli, Vaitsa. "Number perseveration in healthy subjects: Does prolonged stimulus exposure influence performance on a serial addition task?" Advances in Cognitive Psychology 9, no. 1 (March 31, 2013): 15–19. http://dx.doi.org/10.5709/acp-0127-8.

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29

Foa, Edna B., and Sheila A. M. Rauch. "Cognitive Changes During Prolonged Exposure Versus Prolonged Exposure Plus Cognitive Restructuring in Female Assault Survivors With Posttraumatic Stress Disorder." Journal of Consulting and Clinical Psychology 72, no. 5 (2004): 879–84. http://dx.doi.org/10.1037/0022-006x.72.5.879.

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30

Hernandez-Tejada, Melba A., Ron Acierno, and David Sanchez-Carracedo. "Addressing Dropout From Prolonged Exposure: Feasibility of Involving Peers During Exposure Trials." Military Psychology 29, no. 2 (February 6, 2017): 157–63. http://dx.doi.org/10.1037/mil0000137.

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31

Mørkved, N., K. Hartmann, L. M. Aarsheim, D. Holen, A. M. Milde, J. Bomyea, and S. R. Thorp. "A comparison of Narrative Exposure Therapy and Prolonged Exposure therapy for PTSD." Clinical Psychology Review 34, no. 6 (August 2014): 453–67. http://dx.doi.org/10.1016/j.cpr.2014.06.005.

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32

Norr, Aaron M., Derek J. Smolenski, Andrea C. Katz, Albert A. Rizzo, Barbara O. Rothbaum, JoAnn Difede, Patricia Koenen‐Woods, Mark A. Reger, and Greg M. Reger. "Virtual reality exposure versus prolonged exposure for PTSD: Which treatment for whom?" Depression and Anxiety 35, no. 6 (May 7, 2018): 523–29. http://dx.doi.org/10.1002/da.22751.

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33

Kelsey, R., and T. Alvey. "Skin burns from prolonged exposure to wet cement." Journal of the American Podiatric Medical Association 85, no. 6 (June 1, 1995): 315–17. http://dx.doi.org/10.7547/87507315-85-6-315.

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A review and typical case history of a patient with skin burns caused by prolonged exposure to wet cement was presented. This case is similar to other reported cases in the length of exposure, prolonged healing time, and typical scar formation. Burns from prolonged exposure to wet cement can result in potentially devastating long-term sequelae. The dermatologic hazards of wet cement are well recognized; however, many patients have suffered cement burns from working in wet cement. Product education and proper protection appear to be the best preventive measures.
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34

Sardi, Iacopo. "Prolonged exposure to doxorubicin after radiotherapy in glioblastoma." Future Oncology 12, no. 5 (March 2016): 581–83. http://dx.doi.org/10.2217/fon.15.354.

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35

Almeida, A. A., C. A. Curti, V. S. Vassilieff, and I. Vassilieff. "Behavioral manifestations of prolonged mercury exposure in rats." Toxicology Letters 95 (July 1998): 133. http://dx.doi.org/10.1016/s0378-4274(98)80526-2.

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36

WACHTER, KERRI. "Combat/Terrorism PTSD Responds to Prolonged Exposure Tx." Internal Medicine News 39, no. 8 (April 2006): 44. http://dx.doi.org/10.1016/s1097-8690(06)73357-1.

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37

Fu, Hui Qun, Ting Yang, Wei Xiao, Long Fan, Yan Wu, Niccolò Terrando, and Tian Long Wang. "Prolonged Neuroinflammation after Lipopolysaccharide Exposure in Aged Rats." PLoS ONE 9, no. 8 (August 29, 2014): e106331. http://dx.doi.org/10.1371/journal.pone.0106331.

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38

Avashia, B., M. C. Battigelli, W. K. C. Morgan, and R. B. Reger. "Effects of Prolonged Low Exposure to Methyl Isocyanate." Journal of Occupational & Environmental Medicine 38, no. 6 (June 1996): 625–30. http://dx.doi.org/10.1097/00043764-199606000-00015.

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39

Ylikoski, M. E. "Prolonged exposure to gunfire noise among professional soldiers." Scandinavian Journal of Work, Environment & Health 20, no. 2 (April 1994): 87–92. http://dx.doi.org/10.5271/sjweh.1416.

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40

Van Hove, Chris L., Tania Maes, Guy F. Joos, and Kurt G. Tournoy. "Prolonged Inhaled Allergen Exposure Can Induce Persistent Tolerance." American Journal of Respiratory Cell and Molecular Biology 36, no. 5 (May 2007): 573–84. http://dx.doi.org/10.1165/rcmb.2006-0385oc.

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41

Jibani, M., and N. H. Hodges. "Prolonged hypercalcaemia after industrial exposure to vitamin D3." BMJ 290, no. 6470 (March 9, 1985): 748–49. http://dx.doi.org/10.1136/bmj.290.6470.748.

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42

Kohrs, R., and M. E. Durieux. "PROLONGED EXPOSURE TO BUPIVACAINE INHIBITS WHOLE BLOOD COAGULATION." Anesthesia & Analgesia 88, Supplement (February 1999): 277S. http://dx.doi.org/10.1097/00000539-199902001-00276.

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43

Ghafoori, Bita, Marissa C. Hansen, Erika Garibay, and Olga Korosteleva. "Feasibility of Training Frontline Therapists in Prolonged Exposure." Journal of Nervous and Mental Disease 205, no. 4 (April 2017): 283–93. http://dx.doi.org/10.1097/nmd.0000000000000659.

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44

Moses, Allon, Down Zahger, and Gail Amir. "Cholestatic Liver Injury after Prolonged Exposure to Methyldopa." Digestion 42, no. 1 (1989): 57–60. http://dx.doi.org/10.1159/000199826.

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45

KANTELE, A. "Immune Response to Prolonged Intestinal Exposure to Antigen." Scandinavian Journal of Immunology 33, no. 2 (February 1991): 225–29. http://dx.doi.org/10.1111/j.1365-3083.1991.tb03753.x.

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46

Shiojiri, Kaori, Richard Karban, and Satomi Ishizaki. "Prolonged exposure is required for communication in sagebrush." Arthropod-Plant Interactions 6, no. 2 (February 1, 2012): 197–202. http://dx.doi.org/10.1007/s11829-011-9180-1.

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47

Gervasoni, Cristina, Francesco R. Simonetti, Chiara Resnati, Nitin Charbe, Emilio Clementi, and Dario Cattaneo. "Prolonged inductive effect of rifampicin on linezolid exposure." European Journal of Clinical Pharmacology 71, no. 5 (March 18, 2015): 643–44. http://dx.doi.org/10.1007/s00228-015-1833-z.

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48

Peirce, Jessica M., Rebecca L. Schacht, R. K. Brooner, Van L. King, and Michael S. Kidorf. "Incentivizing attendance to prolonged exposure in methadone maintenance." Drug and Alcohol Dependence 156 (November 2015): e175. http://dx.doi.org/10.1016/j.drugalcdep.2015.07.476.

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49

Barosova, Hana, Bedia Begum Karakocak, Dedy Septiadi, Alke Petri-Fink, Vicki Stone, and Barbara Rothen-Rutishauser. "An In Vitro Lung System to Assess the Proinflammatory Hazard of Carbon Nanotube Aerosols." International Journal of Molecular Sciences 21, no. 15 (July 27, 2020): 5335. http://dx.doi.org/10.3390/ijms21155335.

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In vitro three-dimensional (3D) lung cell models have been thoroughly investigated in recent years and provide a reliable tool to assess the hazard associated with nanomaterials (NMs) released into the air. In this study, a 3D lung co-culture model was optimized to assess the hazard potential of multiwalled carbon nanotubes (MWCNTs), which is known to provoke inflammation and fibrosis, critical adverse outcomes linked to acute and prolonged NM exposure. The lung co-cultures were exposed to MWCNTs at the air-liquid interface (ALI) using the VITROCELL® Cloud system while considering realistic occupational exposure doses. The co-culture model was composed of three human cell lines: alveolar epithelial cells (A549), fibroblasts (MRC-5), and macrophages (differentiated THP-1). The model was exposed to two types of MWCNTs (Mitsui-7 and Nanocyl) at different concentrations (2–10 μg/cm2) to assess the proinflammatory as well as the profibrotic responses after acute (24 h, one exposure) and prolonged (96 h, repeated exposures) exposure cycles. The results showed that acute or prolonged exposure to different concentrations of the tested MWCNTs did not induce cytotoxicity or apparent profibrotic response; however, suggested the onset of proinflammatory response.
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50

Castellani, John W., and Andrew J. Young. "Human physiological responses to cold exposure: Acute responses and acclimatization to prolonged exposure." Autonomic Neuroscience 196 (April 2016): 63–74. http://dx.doi.org/10.1016/j.autneu.2016.02.009.

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