Academic literature on the topic 'Prolonged Rupture of Membrane (PROM)'
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Journal articles on the topic "Prolonged Rupture of Membrane (PROM)"
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Ocviyanti, Dwiana, and William Timotius Wahono. "Risk Factors for Neonatal Sepsis in Pregnant Women with Premature Rupture of the Membrane." Journal of Pregnancy 2018 (October 1, 2018): 1–6. http://dx.doi.org/10.1155/2018/4823404.
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Background. Premature rupture of the membrane (PROM) is associated with high maternal as well as perinatal morbidity and mortality risks. It occurs in 5 to 10% of all pregnancy while incidence of amniotic membrane infection varies from 6 to 10%. This study aimed to determine the incidence of neonatal sepsis in Cipto Mangunkusumo Hospital and the risk factors. Methods. A cross-sectional study was done in Cipto Mangunkusumo Hospital, Jakarta, from December 2016 to June 2017. The study used total sampling method including all pregnant women with gestational age of 20 weeks or more experiencing PROM, who came to the hospital at that time. Samples with existing comorbidities such as diabetes mellitus or other serious systemic illnesses such as heart disease or autoimmune condition were excluded from the analysis. Results. A total of 405 pregnant women with PROM were included in this study. There were 21 cases (5.2%) of neonatal sepsis. The analysis showed that risk of neonatal sepsis was higher in pregnant women with prolonged rupture of membrane for ≥ 18 hours before hospital admission (OR 3.08), prolonged rupture of membrane for ≥ 15 hours during hospitalization (OR 7.32), and prolonged rupture of membrane for ≥ 48 hours until birth (OR 5.77). The risk of neonatal sepsis was higher in preterm pregnancy with gestational age of <37 weeks (OR 18.59). Conclusion. Risk of neonatal sepsis is higher in longer duration of prolonged rupture of membrane as well as preterm pregnancy.
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الكعكي, Nahla Saleh. "Prevalence of the pattern of Pre-labor premature rupture of membranes among pregnant women at Al-Sadaqa Teaching Hospital, Aden, Yemen." Journal of medical and pharmaceutical sciences 6, no. 5 (2022): 52–65. http://dx.doi.org/10.26389/ajsrp.h050122.
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Pre-labor rupture of membranes (PROM) is the rupture of membranes before the onset of labor. It is a common obstetric problem (3 -4%) in developed and developing countries. The aim of this study to describe the pattern of PROM in pregnancies at Al-Sadaqa Teaching Hospital, Aden, Yemen from January to February 2020. This is a descriptive hospital based study of the patients diagnosed as PROMs managed in the Obstetrics and Gynecology Department. In this study 151 pregnant women with PROM comprising 11.1% of 1360 total deliveries. Only 9 (0.7%) patients presented with preterm premature rupture of membranes (PPROM) and 142 (10.4%) with term premature rupture of membranes (TPROM). The mean maternal age with PROM was 26.12 ± 6.67 years. With increasing parity, there was a decrease in the PROM; 6.0% in multipara to 4.6% in grand-multipara. The time interval from membrane rupture to delivery was >24 hours in 47% of them. Anemia was the main predisposing factor causing PROMs (47.0%) followed by history of abortion and urinary tract infection (UTI) (29.1%, and 19.9% respectively). About 81.5% of them delivered vaginally while 18.5% by lower segment cesarean section. Conclusions: The prevalence of PROM in this study was comparably higher than the international average. A higher proportion of them delivered vaginally. The major contributing factors were anemia, history of abortion and UTI and increasing risk with prolonged rupture of membrane > 24hrs. It is of paramount importance to screen for UTI with timely treatment initiation and those with recurrent abortion require close monitoring on risk of PROM during subsequent pregnancies.
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Begum, Housneara, Marlina Roy, and Nahid Reaz Shapla. "Perinatal Outcome of Premature Rupture Membrane in Pregnancy." Journal of Dhaka Medical College 26, no. 2 (2018): 135–39. http://dx.doi.org/10.3329/jdmc.v26i2.38831.
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Objective: To find out the effect of PROM on neonatal outcome so that we can pay more attention for the correct diagnosis and management of PROM in pregnancy which can reduce the perinatal mortality and morbidity caused by PROM.Methods: One hundred PROM cases were selected maintaining appropriate inclusion & exclusion criteria from the department of obstetrics & Gynaecology of BSMMU & DMCH and one hundred controlled cases were taken from the same during the period of January 2010 to December 2010. Data were analyzed with SPSS statistical program to determine the effect of PROM on neonatal health.Results: In this study, 44% babies of PROM patients had various type of morbidity compare to 24% of patients with intact membrane. In PROM patients, perinatal mortality was 7% in this study compare to 5% with intact membrane. Causes of perinatal death in PROM was severe asphyxia (4%), RDS (5%) & neonatal sepsis (6%) mainly.Conclusion: All fetal complications were significantly higher in PROM patients who received treatment after prolonged rupture of membrane. Appropriate antibiotic coverage in appropriate time will reduce fetal morbidity.J Dhaka Medical College, Vol. 26, No.2, October, 2017, Page 135-139
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Dixit, Asha. "Outcomes of prolonged preterm premature rupture of the membrane: a report of six cases." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 1 (2018): 329. http://dx.doi.org/10.18203/2320-1770.ijrcog20185447.
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Preterm premature rupture of the membranes (PROM) is associated with significant maternal morbidity and perinatal mortality. With an increasing era of infertility, the main interest of an assisted reproductive technology specialist is to increase the take-home baby rate. Here authors present report on the outcomes of prolonged preterm PROM cases facilitated with expectant management. Report is based on the medical records of six women with preterm PROM between 16-31 weeks of gestation who gave their consent to continue the pregnancy. These women were diagnosed with PROM by the litmus test and per speculum examination. Ultrasound scan and clinical investigation, which included complete blood count and C-reactive protein level, were performed in all cases. Prophylactic antibiotics were administered to prevent the infection and increase the latency period. All six babies (100%) were delivered successfully. There was no foetal mortality and maternal morbidity observed. Expectant management in preterm PROM cases can increase the survival rate and hence the take-home baby rate.
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Alam, Muhammad Matloob, Ali Faisal Saleem, Abdul Sattar Shaikh, Owais Munir, and Maqbool Qadir. "Neonatal sepsis following prolonged rupture of membranes in a tertiary care hospital in Karachi, Pakistan." Journal of Infection in Developing Countries 8, no. 01 (2014): 067–73. http://dx.doi.org/10.3855/jidc.3136.
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Introduction: Prolonged rupture of membrane (PROM) is an important risk factor for early onset neonatal sepsis (EONS), which is associated with increased neonatal morbidity and mortality. We reported the incidence and associated risk factors of PROM for culture-proven EONS. Methodology:The medical records of all neonates born at Aga Khan University, Karachi over a period of five years (2007-2011) with PROM (> 18 hours) were reviewed. Data about maternal and neonatal risk factors for EONS was collected and adjusted logistic regression (AOR) analysis was applied. Results:Incidence of PROM in this neonatal birth cohort was 27/1,000 live births. A total of 17 (4%) cases with blood-culture proven bacterial sepsis were identified within 72 hours of birth. Klebsiella pneumonia (n = 5; 29%) and Pseudomonas aeruginosa (n = 4; 24%) were the commonest isolates followed by group B Streptococcus (n = 3; 18%) and Escherichia coli (n = 2; 12%). Maternal fever (p = <0.001; AOR, 36.6), chorioamnionitis (p < 0.001; AOR, 4.1), PROM > 48 hr. (p < 0.001; AOR, 8.2), neonatal prematurity < 34 weeks (p < 0.001; AOR, 4.1) and low birth weight < 1,500 grams (p 0.001; AOR, 9.8) along with neonatal thrombocytopenia and raised CRP were found to be independent risk factors associated with culture-proven EONS in PROM. Conclusions: Preventive measures should focus on recognition of these high-risk infants with prompt laboratory screening for sepsis and early institution of empirical antibiotic based on local data. Such approaches would be a safe and cost-effective strategy, especially in developing countries.
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Rufaida, Zulfa. "Proporsi Asfiksia Neonatorum pada Kasus KPD dengan Non KPD di RSUD dr. Mohammad Soewandhi Surabaya." Jurnal Kebidanan Midwiferia 2, no. 1 (2016): 34–44. http://dx.doi.org/10.21070/mid.v2i1.762.
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Severe fetal or asphyxia intrauterin can be a result of cord compression and repetitive due to prolonged reduction prolapsus amniotic fluid or umbilical cord. Complications are most common in PROM before 37 weeks gestation is respiratory distress syndrome (asphyxia), which occurs in 10-40% of new born babies. Risk of infection, disability, and death was also increased in the PROM events. This research methods, analytical case control study design. Inpartu mother population in maternity hospitals VK dr. Mohamad Soewandhie Surabaya in 2008 some 2101 cases. Sampling techniques proportional stratified random sampling. Large sample of 67 cases. Independent variable, premature rupture of membranes (PROM) and the dependent variable, neonates asphyxia. Instruments used data collection sheets. Sources of data from medical records. Analysis of data using non-parametric statistical approach Chi Square. The results of 33 cases of maternal inpartu that experience premature rupture of membranes (PROM), had 20.9% asphyxia and from were 34 cases of inpartu mothers who did not KPP, 20.9% experienced not asphyxia. Chi Square test results, X2arhitetic <X2table (1.802 <3.48) means that there is no difference in incidence neonates asphyxia in premature rupture cases (KPP) and no premature rupture of membranes (non – KPP). The conclusion of this study, less than 50% of inpartu mothers who experienced premature rupture of membranes (PROM), and more than 50% occurred asphyxia was, and there was no difference in incidence neonates asphyxia in premature rupture cases (KPP) and no premature rupture of membranes (non – KPP).
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S, Jayashalini. "A Retrospective Study on Maternal and Fetal Outcomes in Premature Rupture of Membranes." Journal of Neonatal Surgery 14, no. 8S (2025): 60–68. https://doi.org/10.52783/jns.v14.2495.
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Background: Premature rupture of membranes (PROM) at term (≥37 weeks) complicates 8–10% of pregnancies and is associated with increased maternal and neonatal morbidity. The optimal management strategy—expectant management versus immediate induction—remains debated. Prolonged PROM (>24 hours) has been linked to increased risks of chorioamnionitis, postpartum haemorrhage, neonatal sepsis, and NICU admissions. This study evaluates maternal and fetal outcomes in PROM cases to guide clinical decision-making. Methods: This hospital-based retrospective study was conducted at Chettinad Health and Research Institute, Tamil Nadu, India, analysing medical records of 100 women diagnosed with PROM at ≥37 weeks gestation (January 1, 2023 – December 31, 2023). Data included maternal demographics, mode of delivery, time from PROM to delivery, maternal complications, and neonatal outcomes. Statistical Analysis: Descriptive statistics, Chi-square tests, logistic regression, Pearson correlation, and Kaplan-Meier survival analysis were performed using SPSS v26.0. A p-value <0.05 was considered statistically significant. Results: Maternal Outcomes: 72% delivered vaginally, while 28% required cesarean delivery due to fetal distress (11%), failure to progress (9%), and chorioamnionitis (5%). The mean latency period from PROM to delivery was 12.8 ± 5.6 hours. Chorioamnionitis (7%) was the most common maternal complication, significantly increasing when PROM lasted >24 hours (29% vs. 3%, p=0.004). Neonatal Outcomes: 16% required NICU admission, primarily due to respiratory distress syndrome (8%) and neonatal sepsis (6%). Prolonged PROM was significantly associated with a 5.2-fold higher risk of NICU admission (p=0.002) and a 4.7 times increased risk of neonatal sepsis (p=0.001). Perinatal mortality was 2%. Negative correlation between PROM duration and APGAR scores (r=-0.58 at 1 min, p<0.001). Kaplan-Meier analysis showed higher neonatal morbidity with PROM >24 hours (p<0.001, log-rank test). Conclusion: Prolonged PROM (>24 hours) significantly increases maternal infections and neonatal morbidity, including higher NICU admissions and neonatal sepsis risk. Timely labour induction within 12 hours may reduce these complications, supporting proactive management strategies over expectant management. Future studies should focus on optimal timing for labour induction in terms of PROM and infection prevention strategies to improve maternal and neonatal outcomes.
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Gyeltshen, Nidup, and Rojna Rai. "Maternal and fetal outcome of term pre labour rupture of membrane in a regional referral hospital in Bhutan from 2018-2020: a retrospective cross sectional study." Bhutan Health Journal 8, no. 1 (2022): 8–13. http://dx.doi.org/10.47811/bhj.131.
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Introduction: Term premature or prelabour rupture of membrane (PROM) refers to the disruption in fetal membranes before the onset of labor, after 37 weeks of gestation. PROM is commonly encountered in our practice but there is no published study on PROM in our country. This study was conducted to determine the incidence, clinical profile and it’s association with maternal and fetal outcome in term PROM in our hospital. Methods: A retrospective cross sectional study, carried out at a regional referral hospital in Bhutan. Medical records-based data was collected from clinically diagnosed cases of term PROM, from 1st January 2018 to 31st December 2020. Results: The incidence of term PROM among deliveries was 5.5 %. Unfavourable maternal outcome was seen in Primigravida (p-value=0.05), PROM duration greater than or equal to 24 hours (p-value= 0.007), Prolonged latency period of 24 hours or more (p-value=0.03), prophylactic antibiotics after 18 hours (p-value=0.05) and vaginal delivery (p-value=0.0001). Unfavourable fetal outcome was observed in cases referred in from regional health centres (p-value=0.01). Conclusions: Early initiation of appropriate prophylactic antibiotics, Early induction of labour as opposed to expectant management, Prompt referral of all PROM cases from primary health centres and district hospitals and availability of appropriate prophylactic antibiotics at all health centres may improve maternal and fetal outcome in term PROM.
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Memon, M. Hanif, Shahina Hanif, Farhan Saeed, et al. "Effect of Maternal Colonization with History of Prolonged Rupture of Membrane on Neonatal Colonization and Early Onset Sepsis." ANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & DENTAL COLLEGE 24, no. 4 (2020): 195–99. http://dx.doi.org/10.58397/ashkmdc.v24i4.165.
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AbstractObjective: To determine the effect of maternal colonization with history of PROM on neonatal colonization and early-onset sepsis.Methods: A descriptive cross-sectional study was carried out at a single tertiary care hospital of Karachi from June 1st 2018 to May 31st 2019. A total of 155 patients' full-term new-borns between 37 to 41 weeks of gestation with a history of rupture of membranes more than 18 hours duration was selected by convenience sampling method. A high vaginal swab was collected from all full-term pregnant women with a history of PROM. After delivery of their new-borns, all babies were kept in the nursery under closed observation for 72 hours duration and their blood cultures, CRP (C- Reactive Protein) and CBC (complete blood count) was sent within 24 hours of delivery.Results: In our study, out of 155 PROM cases 58 (37.4) were growth positive and 50 (32.3) neonates had positive blood C/S at delivery. Out of 58 cases with suspected growth positive PROM mothers 51 had gram-negative organisms in HVS while only 7 mothers were gram-positive in HVS. Of all neonates with positive blood C/S at delivery 44 cases were gram-negative organisms in their blood.Conclusion: In our study organisms found in a high vaginal swab of the mother are similar to the organisms found in the blood culture of their new-born with early-onset sepsis.
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Shakya, Amshu, and Sweta Kumari Gupta. "Neonatal outcome of maternal premature rupture of membranes more than 18 hours." Journal of Kathmandu Medical College 9, no. 2 (2020): 81–86. http://dx.doi.org/10.3126/jkmc.v9i2.35526.
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Background: Premature Rupture of Membranes has been known to complicate pregnancy since ages. Several risk factors may be associated with occurrence of premature rupture of membranes. It is associated with varied neonatal complications, neonatal sepsis and prematurity being the most hazardous ones.
 Objectives: This study was conducted to evaluate the incidence of neonatal sepsis following premature rupture of membranes, risk factors and neonatal complications associated with premature rupture of membrane of more than 18 hours in the neonates admitted in a tertiary care center.
 Methodology: Descriptive observational study was undertaken for 18 months from August 2013 to January 2015 in the College of Medical Sciences, Chitwan, Nepal. This study included 82 neonates admitted to the Neonatal Intensive Care Unit with maternal history of premature rupture of membranes of more than 18 hours with medical conditions excluded. 
 Results: The incidence of premature rupture of membranes in this hospital was 8.9%. Frequently associated maternal risk factors were history of prior abortion (16, 19.5%), urinary tract infection (7, 8.5%), and antecedent coitus (7, 8.5%). In the study population, 68 (83%) neonates had complications and 14 (17%) neonates had no complication. The incidence of neonatal sepsis following PROM in present study was 6.1%. Neonatal sepsis was significantly associated with chorioamnionitis (p<0.001). The most frequently occurring complication was probable neonatal sepsis (53, 64.6%), followed by prematurity (31, 37.8%) and perinatal asphyxia (15, 18.3%). There was a directly proportional relation of neonatal sepsis, chorioamnionitis, respiratory distress syndrome and mortality with duration of premature rupture of membranes.
 Conclusion: Commonly occurring maternal risk factors with PROM were prior abortion, UTI and antecedent coitus. In the study population, infectious morbidity was highest. Chorioamnionitis was significantly associated with culture proven neonatal sepsis. Prolonged duration of premature rupture of membranes increased the risk of neonatal sepsis, meningitis, respiratory distress syndrome and perinatal death. Prevention of these risk factors, appropriate and timely management including improved obstetric and neonatal care can provide intact survival of the neonates.
Book chapters on the topic "Prolonged Rupture of Membrane (PROM)"
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Kohari, Katherine S., and Christian M. Pettker. "Antibiotics for Preterm Premature Rupture of Membranes." In 50 Studies Every Obstetrician-Gynecologist Should Know. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780190947088.003.0008.
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Antibiotics for preterm prelabor rupture of membranes (PPROM) have been shown to prolong the length of pregnancy as well as improve neonatal outcomes as demonstrated by the landmark article by Mercer et al. PPROM complicates 3% of all pregnancies, and approximately one-half of patients will deliver within 1 week of membrane rupture. Infection is thought to play a role in both the etiology of PPROM and subsequent maternal and neonatal complications. Premature birth further complicates neonatal outcomes, therefore prolongation of pregnancy after PPROM is essential for risk reduction. Administration of broad spectrum antibiotics have been associated with prolonged latency in women with PPROM at less than 32 weeks and 0 days of gestation as well as improved neonatal outcomes.
Conference papers on the topic "Prolonged Rupture of Membrane (PROM)"
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Syamsi, Efrida Yusriyanti, and Nuli Nuryanti Zulala. "Premature Rupture of Membrane (PROM) Increasing Asphyxia Neonatorum Risk." In International Conference on Health and Medical Sciences (AHMS 2020). Atlantis Press, 2021. http://dx.doi.org/10.2991/ahsr.k.210127.053.
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Taskin, M. Ertan, Tao Zhang, Berry Gellman, Kurt A. Dasse, Bartley P. Griffith, and Zhongjun J. Wu. "3D Flow Modeling and Blood Damage Characterization of the UltraMag™ Blood Pump." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192105.
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Cardiovascular and lung diseases are the leading causes of death and disability worldwide. There are many therapies available for their treatment such as simple lifestyle changes, medicines, and surgical intervention or corrections. For the cases where the above treatments do not alleviate the patients’ conditions, the use of artificial devices may be the only option to treat or replace the diseased organ(s). However, the consideration of blood containing biomedical devices may introduce a prolonged contact between the blood and inorganic surfaces which induces variety of blood damages including hemolysis due to the creation of non-physiological mechanical shear stress field. Hemolysis is the release of hemoglobin from the red blood cells (RBC) as a result of the rupture of RBC membrane due to these unavoidable mechanical effects. For that reason, characterization of fluid dynamics and hemolytic performance is the key step to evaluate the design of biomedical devices.
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Mendygarin, Yertay, Luis R. Rojas-Solórzano, Nurassyl Kussaiyn, Rakhim Supiyev, and Mansur Zhussupbekov. "Eulerian-Eulerian Multiphase Modeling of Blood Cells Segregation in Flow Through Microtubes." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-70850.
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Cardiovascular Diseases, the common name for various Heart Diseases, are responsible for nearly 17.3 million deaths annually and remain the leading global cause of death in the world. It is estimated that this number will grow to more than 23.6 million by 2030, with almost 80% of all cases taking place in low and middle income countries. Surgical treatment of these diseases involves the use of blood-wetted devices, whose relatively recent development has given rise to numerous possibilities for design improvements. However, blood can be damaged when flowing through these devices due to the lack of biocompatibility of surrounding walls, thermal and osmotic effects and most prominently, due to the excessive exposure of blood cells to shear stress for prolonged periods of time. This extended exposure may lead to a rupture of membrane of red blood cells, resulting in a release of hemoglobin into the blood plasma, in a process called hemolysis. Moreover, exposure of platelets to high shear stresses can increase the likelihood of thrombosis. Therefore, regions of high shear stress and residence time of blood cells must be considered thoroughly during the design of blood-contacting devices. Though laboratory tests are vital for design improvements, in-vitro experiments have proven to be costly, time-intensive and ethically controversial. On the other hand, simulating blood behavior using Computational Fluid Dynamics (CFD) is considered to be an inexpensive and promising tool to help predicting blood damage in complex flows. Nevertheless, current state-of-the-art CFD models of blood flow to predict hemolysis are still far from being fully reliable and accurate for design purposes. Previous work have demonstrated that prediction of hemolysis can be dramatically improved when using a multiphase (i.e., phases are plasma, red blood cells and platelets) model of the blood instead of assuming the blood as a homogeneous mixture. Nonetheless, the accurate determination of how the cells segregate becomes the critical issue in reaching a truthful prediction of blood damage. Therefore, the attempt of this study is to develop and validate a numerical model based on Granular Kinetic Theory (GKT) for solid phases (i.e., cells treated as particles) that provides an improved prediction of blood cells segregation within the flow in a microtube. Simulations were based on finite volume method using Eulerian-Eulerian modeling for treatment of three-phase (liquid-red blood cells and platelets) flow including the GKT to deal with viscous properties of the solid phases. GKT proved to be a good model to predict particle concentration and pressure drop by taking into account the contribution of collisional, kinetic and frictional effects in the stress tensor of the segregated solid phases. Preliminary results show that the improved segregated model leads to a better prediction of spatial distribution of blood cells. Simulations were performed using ANSYS FLUENT platform.