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Relevant bibliographies by topics / Proofreading

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Dissertations / Theses

Academic literature on the topic 'Proofreading'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 June 2025

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Dissertations / Theses on the topic "Proofreading"

1

Jones, Alexander Stephen. "Proofreading of substrate by the Escherichia coli Twin Arginine Translocase." Thesis, University of Kent, 2017. https://kar.kent.ac.uk/65666/.

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The Twin Arginine Translocase (Tat) is one of two protein translocation mechanisms in E. coli to move proteins across the inner bacterial membrane, from the cytosol to the periplasm. A unique feature of the Tat pathway is its ability to translocate fully folded proteins, indeed, in E. coli the Tat pathway preferentially transports correctly folded proteins. This 'proofreading' mechanism, as it has been dubbed, is of interest to the biopharmaceutical industry, however little is known of the mechanism by which Tat proofreads a substrates conformational state. Initial studies (chapter 3) addressed if the Tat proofreading mechanism sensed the surface charge or hydrophobicity of a substrate. To this end, surface residues of an scFv were mutated to create areas of charge and hydrophobicity without altering tertiary structure. Expression of these variants in E. coli revealed that Tat proofreading is tolerant of surface charge and hydrophobicity, but dependent on conformational flexibility. Further studies utilising a maquette in various folding states, confirmed Tat proofreading is sensitive to the structural rigidity of substrates (chapter 4). Investigations then went on to assess the quality of protein entering the periplasm via the Tat pathway by comparing it to the same protein transported by the General Secretory (Sec) pathway (chapter 5). This revealed, at least for a relatively simple biotheraputic, Tat-translocated protein is of the same quality to Sec-translocated protein. Finally, the question of what is responsible for the proofreading ability of Tat began to be addressed through C-terminal truncation studies of the Tat components that attempted to restore export of export-incompatible substrates (chapter 6).

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2

Walsh-Betthauser, Kimberly. "Assessment of proofreading and editing with technical diploma students at Western Wisconsin Technical College - Mauston." Online version, 1999. http://www.uwstout.edu/lib/thesis/1999/1999walsh-b.pdf.

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3

Dow, Jennifer Mhairi. "Probing the role of Tat proofreading chaperones in the assembly of molybdoenzymes." Thesis, University of Dundee, 2013. https://discovery.dundee.ac.uk/en/studentTheses/8b7d7f2d-3aa8-48ce-a9eb-ec8a7d2e341f.

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The twin-arginine (Tat) system is a specialised translocation machine found in prokaryotes and chloroplasts which serves to export fully folded proteins across the cytoplasmic membrane. Proteins are specifically targeted to this system by N-terminal signal peptides which bear a conserved SRRxFLK motif. Tat dependent proteins often contain redox factors that must be inserted prior to translocation. The E. coli Tat substrates trimethylamine Noxide reductase (Tor) and periplasmic nitrate reductase (Nap) are two such substrates which require the molybdenum cofactor Mo-bis-MGD in order to function as anaerobic reductases. Pre-export assembly of Tor and Nap are subject to a process called Tat proofreading, where the substrate specific chaperones, TorD and NapD, bind tightly to the signal peptides of these substrates, TorA and NapA, respectively, assisting in the assembly of the proteins. Work described in this thesis demonstrates that TorD simultaneously binds to two independent sites present on the TorA, one present in the mature domain of the substrate and one in the signal peptide. Biophysical and structural analysis shows that the pre-export complexes of TorD and TorA appear identical regardless of whether the TorA signal peptide is present or absent. However, the complex purified in the absence of the TorA signal peptide is able to interact with extrinsically-added signal peptide, confirming the presence of a separate signal peptide binding site. By contrast to TorD, NapD was shown to bind exclusively to the signal peptide of its substrate, NapA. Pre-export complexes of TorAD and NapDA showed similar low resolution structures, with both NapA and TorA exhibiting flexibility in Domain IV. It is hypothesised that this Domain acts as a gate, allowing access of the cofactor, and that closing of this gate is the final step in the folding of the substrate.

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4

Seibel, Karen Kuhla. "Analysis of errors located by business students in hardcopy versus softcopy documents." Thesis, Virginia Polytechnic Institute and State University, 1988. http://hdl.handle.net/10919/52074.

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The problem of this study was to examine errors located by subjects proofreading hardcopy versus softcopy business documents. Hardcopy refers to a business document typed or printed on paper; softcopy refers to a business document displayed on a computer screen. Data were obtained by 61 Southwest Virginia high school business students completing a background information sheet and proofreading the same three documents—a letter, a report, and a memo—on both hardcopy and softcopy media; for each media, the students proofread each document for 15 to 20 minutes over a 1-hour period. The number and types of errors found, the number of times each document was proofread, and personal characteristics of the subjects were analyzed. The following outcomes are based on the results of the study: (a) subjects located the same number of errors when proofreading from hardcopy and softcopy media; (b) subjects located one to two more errors in the letters and reports than in the memos; (c) the medium was not related to the specific types of errors found; (d) subjects who proofread a document five times located one to two more errors than those who proofread fewer times; (e) subjects with 0 to 2 years of computer experience located one more error than those with more experience. The two main conclusions of the study were: (a) students need not print hardcopies of documents in an attempt to locate more errors than in softcopy documents; and (b) teachers should be aware that students are more likely to locate some types of errors than others.<br>Master of Science

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5

Smith, Toria. "Amending the Record: Proofreading American Naval War Diaries Written in the Pontus, 1921-1922." ScholarWorks@UNO, 2019. https://scholarworks.uno.edu/td/2644.

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6

Rebuck, Mark. "Feedback on Feedback: An Analysis of L2 Writers’ Evaluations of Proofreaders." 名古屋大学教養教育院, 2014. http://hdl.handle.net/2237/21064.

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7

Lancy, Edward Donald Jr. "Genetic requirements for growth of Salmonella typhimurium lacking the proofreading subunit of DNA polymerase III." Case Western Reserve University School of Graduate Studies / OhioLINK, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=case1054846339.

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8

Myers, Melissa Anne. "Isolation, purification, and characterization of a proofreading-deficient DNA polymerase from Mycoplasma capricolum, subsp. capricolum 14 /." The Ohio State University, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487864485230423.

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9

Steiner, Rebecca Elizabeth. "Regulation of Translational Quality Control by Phenylalanyl-tRNA Synthetase." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1561468654993642.

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10

Seevers, Randy Lee. "The use of self-managed proofreading for detecting and correcting mechanical errors by students with a learning disability /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487940308432861.

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