Relevant bibliographies by topics / Proopiomelanocortin (POMC)

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  2. Dissertations / Theses
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Academic literature on the topic 'Proopiomelanocortin (POMC)'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Proopiomelanocortin (POMC)"

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Thornton, Janice E., Clement C. Cheung, Donald K. Clifton, and Robert A. Steiner. "Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice." Endocrinology 138, no. 11 (1997): 5063–66. http://dx.doi.org/10.1210/endo.138.11.5651.

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The hormone leptin acts on the brain to regulate feeding, metabolism, and reproduction; however, its cellular targets and molecular mechanisms of action remain to be fully elucidated. The melanocortins, which are derived from the precursor proopiomelanocortin (POMC), are also implicated in the physiological regulation of body weight. POMC-containing neurons express the leptin receptor, and thus it is conceivable that the POMC gene itself may be part of the signaling pathway involved in leptin’s action on the brain. Using in situ hybridization and computerized image analysis, we tested the hypo
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Krude, Heiko, and Annette Grüters. "Implications of Proopiomelanocortin (POMC) Mutations in Humans: The POMC Deficiency Syndrome." Trends in Endocrinology & Metabolism 11, no. 1 (2000): 15–22. http://dx.doi.org/10.1016/s1043-2760(99)00213-1.

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Coll, Anthony P., I. Sadaf Farooqi, Benjamin G. Challis, Giles S. H. Yeo, and Stephen O’Rahilly. "Proopiomelanocortin and Energy Balance: Insights from Human and Murine Genetics." Journal of Clinical Endocrinology & Metabolism 89, no. 6 (2004): 2557–62. http://dx.doi.org/10.1210/jc.2004-0428.

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Abstract Proopiomelanocortin (POMC) undergoes extensive and tissuespecific posttranslational processing to yield a range of biologically active peptides. Historically, the most clearly defined roles of these peptides are in the control of adrenal steroidogenesis by corticotroph-derived ACTH and skin pigmentation by αMSH. However, a rapidly expanding body of work has established that POMC-derived peptides synthesized in neurons of the hypothalamus play a central role in the control of energy homeostasis. We review how inherited abnormalities in POMC synthesis and processing and defects in the a
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Tallman, Diana L., and Carla G. Taylor. "Potential interactions of zinc in the neuroendocrine-endocrine disturbances of diabetes mellitus type 2." Canadian Journal of Physiology and Pharmacology 77, no. 12 (1999): 919–33. http://dx.doi.org/10.1139/y99-111.

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An accumulation of evidence implicates leptin, insulin, glucocorticoids, proopiomelanocortin (POMC), and neuropeptide Y (NPY) interactions as being integral to metabolic control associated with neuroendocrine-endocrine functioning. Dysfunction of neuroendocrine-endocrine interactions contributes to the metabolic disturbances of diabetes mellitus type 2 (DM-2). Since Zn has a direct impact on the healthy functioning of hormonal and neuropeptide balance, it is possible that altered Zn status and metabolism in DM-2 are involved in some of the metabolic dysfunctions of DM-2.Key words: zinc, insuli
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Clark, Adrian J. L. "60 YEARS OF POMC: The proopiomelanocortin gene: discovery, deletion and disease." Journal of Molecular Endocrinology 56, no. 4 (2016): T27—T37. http://dx.doi.org/10.1530/jme-15-0268.

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The cloning of the bovine proopiomelanocortin (POMC) cDNA in 1978 by Nakanishi and colleagues was the result of a remarkable series of exacting and ingenious experiments. With this work, they instantly confirmed the single precursor hypothesis for adrenocorticotrophic hormone-β-lipotropin, as it was then known, and in so doing revealed the existence of additional, largely unpredicted, N-terminal peptides that together formed the POMC precursor peptide. This work paved the way for a host of additional studies into the physiology of these peptides and their regulation. Furthermore, the cloning o
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Navarro, Sandra, Lucia Soletto, Sara Puchol, Josep Rotllant, Jose Luis Soengas, and Jose Miguel Cerdá-Reverter. "60 YEARS OF POMC: POMC: an evolutionary perspective." Journal of Molecular Endocrinology 56, no. 4 (2016): T113—T118. http://dx.doi.org/10.1530/jme-15-0288.

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Proopiomelanocortin (POMC) is a complex precursor that comprises several peptidic hormones, including melanocyte-stimulating hormones (MSHs), adrenocorticotropic hormone (ACTH), and β-endorphin. POMC belongs to the opioid/orphanin gene family, whose precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF). This gene family diversified during early tetraploidizations of the vertebrate genome to generate four different precursors: proenkephalin (PENK), prodynorphin (PDYN), and nociceptin/proorphanin (PNOC) as well as POMC, although both PNOC and POMC seem to have
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Newell-Price, J. "Proopiomelanocortin gene expression and DNA methylation: implications for Cushing's syndrome and beyond." Journal of Endocrinology 177, no. 3 (2003): 365–72. http://dx.doi.org/10.1677/joe.0.1770365.

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Proopiomelanocortin gene (POMC) is recognised as playing an important role in the regulation of the hypothalamo-pituitary-adrenal axis, adrenal development and obesity. POMC is activated in ACTH-dependent Cushing's syndrome. The syndrome may occur when the highly tIssue-specific 5' promoter of human POMC is activated in pituitary and non-pituitary sites. Whilst the factors involved in transcription in the corticotrophs of the anterior pituitary gland are becoming well delineated, the mechanism of activation in non-pituitary sites is not fully understood. This promoter is embedded within a defi
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Slominski, Andrzej, Jacobo Wortsman, Thomas Luger, Ralf Paus, and Samuel Solomon. "Corticotropin Releasing Hormone and Proopiomelanocortin Involvement in the Cutaneous Response to Stress." Physiological Reviews 80, no. 3 (2000): 979–1020. http://dx.doi.org/10.1152/physrev.2000.80.3.979.

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The skin is a known target organ for the proopiomelanocortin (POMC)-derived neuropeptides α-melanocyte stimulating hormone (α-MSH), β-endorphin, and ACTH and also a source of these peptides. Skin expression levels of the POMC gene and POMC/corticotropin releasing hormone (CRH) peptides are not static but are determined by such factors as the physiological changes associated with hair cycle (highest in anagen phase), ultraviolet radiation (UVR) exposure, immune cytokine release, or the presence of cutaneous pathology. Among the cytokines, the proinflammatory interleukin-1 produces important upr
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de Souza, Flávio S. J., Andrea M. Santangelo, Viviana Bumaschny, et al. "Identification of Neuronal Enhancers of the Proopiomelanocortin Gene by Transgenic Mouse Analysis and Phylogenetic Footprinting." Molecular and Cellular Biology 25, no. 8 (2005): 3076–86. http://dx.doi.org/10.1128/mcb.25.8.3076-3086.2005.

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ABSTRACT The proopiomelanocortin (POMC) gene is expressed in the pituitary and arcuate neurons of the hypothalamus. POMC arcuate neurons play a central role in the control of energy homeostasis, and rare loss-of-function mutations in POMC cause obesity. Moreover, POMC is the prime candidate gene within a highly significant quantitative trait locus on chromosome 2 associated with obesity traits in several human populations. Here, we identify two phylogenetically conserved neuronal POMC enhancers designated nPE1 (600 bp) and nPE2 (150 bp) located approximately 10 to 12 kb upstream of mammalian P
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Ancans, Janis, Anthonny J. Thody, John M. Wood, Wayne D. Beazley, and Karin U. Schallreuter. "Human Epidermal Proopiomelanocortin (POMC) cDNA Variant is Identical to Mouse POMC cDNA." Journal of Investigative Dermatology 112, no. 4 (1999): 516–17. http://dx.doi.org/10.1046/j.1523-1747.1999.00539.x.

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Dissertations / Theses on the topic "Proopiomelanocortin (POMC)"

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Paula, Bruna Morais Faleiros de. "Padrões de metilação e expressão do gene Pomc na prole de ratas submetidas às dietas deficiente e suplementada com ácido fólico." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17138/tde-30032017-093539/.

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A epigenética é uma subárea da Genética, na qual são estudados mecanismos que são essenciais para o adequado desenvolvimento dos mamíferos, sendo que, alterações neste estágio podem levar a vários distúrbios metabólicos, como a obesidade. Atualmente a obesidade é um grave problema de saúde pública mundial, tem origem multifatorial envolvendo tanto fatores ambientais quanto genéticos. Existem alguns genes que estão envolvidos com a obesidade, como por exemplo, o gene da pró-opiomelanocortina (POMC). O objetivo do presente projeto de pesquisa é investigar os padrões de expressão e metilação do g
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Millington, George William Mark. "The role of proopiomelanocortin (POMC) in the control of food intake : functional, neuroanatomical and genetic studies." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613823.

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Wagner, Kathrin. "Überprüfung der Expression des Proopiomelanocortin (POMC)-Gens in HaCaT- und A-431-Zellkulturen unter Basal- und Stimulationsbedingungen." Wettenberg : VVB Laufersweiler, 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976093316.

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Mischke, Mona. "DNA methylation of the POMC gene." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16456.

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Adipositas ist eine polymorphe chronische Erkrankung mit epidemischer Prävalenz. Im katabolen Leptin-Melanocortin-Signalweg ist das Proopiomelanocortin Gen (POMC) ein zentrales Element, das bei Dysfunktion massive Adipositas bewirken kann. Auch eine kürzlich identifizierte intragenische Methylierungsvariante des POMC wurde mit Adipositas assoziiert und deutet somit auf eine mögliche epigenetische Modulation des Gewichtsphänotyps hin. Zur Aufklärung der Relevanz, Stabilität und Entwicklung dieser epigenetischen Modifikation wurden die Funktionalität, Ontogenese und Phylogenese der POMC DNA-Meth
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Wagner, Kathrin [Verfasser]. "Überprüfung der Expression des Proopiomelanocortin (POMC)-Gens in HaCaT- und A-431-Zellkulturen unter Basal- und Stimulationsbedingungen / Kathrin Wagner." Wettenberg : VVB Laufersweiler, 2005. http://d-nb.info/976093316/34.

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Cuestas, Ruiz de Temiño Mª del Pilar. "Cuantificación de la expresión del gen proopiomelanocortina (POMC) en linfocitos periféricos de pacientes sometidos a cirugía, bajo anestesia intradural." Doctoral thesis, Universitat Autònoma de Barcelona, 2008. http://hdl.handle.net/10803/4321.

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INTRODUCCIÓN<br/>Las variaciones en la expresión genética del sistema opioide endógeno pueden aportarnos nuevos parámetros para valorar la eficacia analgesica por via intratecal de anestésicos locales y opiáceos, su influencia sobre el estrés perioperatorio y la rehabilitación postoperatoria .<br/>OBJETIVOS<br/>1.- Cuantificar las variaciones de la expresión del gen POMC en linfocitos periféricos y los niveles plasmáticos de ACTH, que ocurren durante el estrés anestésico - quirúrgico, utilizando anestesia loco regional subaracnoidea con bupivacaína más metadona.<br/>2.- Estudiar las variacione
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MONNIER, DOMINIQUE. "Regulations transcriptionnelles des genes de la proopiomelanocortine (pomc) et de la proenkephaline (penk) par le pituitary adenylate cyclase-activating polypeptide (pacap)." Université Louis Pasteur (Strasbourg) (1971-2008), 1995. http://www.theses.fr/1995STR13214.

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Le pituitary adenylate cyclase activating polypeptide (pacap) est un neurotransmetteur des systemes nerveux centraux et peripheriques, existant sous deux formes: le pacap 27 le pacap 38. Trois types de recepteurs de ce peptide sont caracterises. Le recepteur de type i peut activer deux voies de messageries intracellulaires distinctes: celle dependant de l'ampc et celle dependant des phosphatidyls inositols. L'objet de cette etude est l'analyse du role regulateur du pacap sur l'expression de deux genes hormonaux: la pro-opiomelanocortine (pomc) et la pro-enkephaline (penk). Ces genes codent des
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CHAUVEAU, ISABELLE. "Etude de la proopiomelanocortine (pomc) et de son role eventuel dans la regulation centrale de la reproduction chez la truite arc-en-ciel (oncorhynchus mikiss)." Rennes 1, 1996. http://www.theses.fr/1996REN10044.

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La proopiomelanocortine (pomc) est un polypeptide dont les differents peptides derives (acth, msh, endorphines) ont un spectre d'activite tres large que ce soit chez les mammiferes ou chez les poissons. La recherche d'une implication dans la regulation centrale de la reproduction chez la truite arc-en-ciel (oncorhynchus mykiss) fait l'objet du present travail. Dans un premier temps, nous avons etudie la localisation des cellules exprimant les deux genes pomc (a et b) mis en evidence precedemment chez la truite arc-en-ciel. Les deux genes sont exprimes differemment dans l'hypothalamus et les di
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Kauser, Sobia, Anthony J. Thody, Karin U. Schallreuter, C. L. Gummer, and Desmond J. Tobin. "A fully functional proopiomelanocortin/melanocortin-1 receptor system regulates the differentiation of human scalp hair follicle melanocytes." 2005. http://hdl.handle.net/10454/3456.

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No<br>The proopiomelanocortin (POMC)-derived peptides, ACTH and alpha-MSH, are the principal mediators of human skin pigmentation via their action at the melanocortin-1 receptor (MC-1R). Recent data have demonstrated the existence of a functionally active beta-endorphin/mu-opiate receptor system in both epidermal and hair follicle melanocytes, whereby beta-endorphin can regulate melanogenesis, dendricity, and proliferation in these cells. However, a role for ACTH and alpha-MSH in the regulation of the human follicular pigmentary unit has not been determined. This study was designed to examine
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Hain, Birgit [Verfasser]. "Untersuchungen zur Expression von Proopiomelanocortin (POMC) in den Hautzellinien des Menschen HaCaT, Colo 679 und A 431 / vorgelegt von Birgit Hain." 2005. http://d-nb.info/978049292/34.

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Book chapters on the topic "Proopiomelanocortin (POMC)"

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Baker, Julien S., Fergal Grace, Lon Kilgore, et al. "POMC-Proopiomelanocortin." In Encyclopedia of Exercise Medicine in Health and Disease. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2884.

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Allen, Richard G. "Adrenocorticotropic Hormone (ACTH) and Other Proopiomelanocortin (POMC) Peptides." In Encyclopedia of Hormones. Elsevier, 2003. http://dx.doi.org/10.1016/b0-12-341103-3/00010-3.

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Horvath, Eva, and Kalman Kovacs. "Histopathology of pituitary tumours." In Oxford Textbook of Endocrinology and Diabetes. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199235292.003.2063.

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The human pituitary gland consists of two major components: the adenohypophysis comprising the hormone producing cells of the pars anterior, pars intermedia, and pars tuberalis, and the neurohypophysis, also called pars nervosa or posterior lobe (1). In contrast to most mammalian species, the human gland has no anatomically distinct pars intermedia (2). The exclusively proopiomelanocortin (POMC)-producing cells of the pars intermedia are sandwiched between the anterior and posterior lobes in the majority of mammals, whereas in the human they are incorporated within the pars anterior, thereby constituting the pars distalis (3). The pars tuberalis is a minor upward extension of the adenohypophysis attached to the exterior of the lower pituitary stalk. In this chapter we deal only with adenohypophyseal tumours. Histologically, the adenohypophysis consists of a central median (or mucoid) wedge flanked by the two lateral wings. The hormone-producing cell types are distributed in an uneven, but characteristic manner. The cells are arranged within evenly sized acini surrounded by a delicate but well-defined reticulin fibre network giving the pituitary its distinct architecture (4). In the center of the acini is the long-neglected pituitary follicle composed of the agranular nonendocrine folliculo-stellate cells (5).
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Page-Wilson, Gabrielle, Elena Reitman-Ivashkov, Kana Meece, et al. "Cerebrospinal Fluid (CSF) Levels of Proopiomelanocortin (POMC) and Agouti-Related Protein (AgRP) in Human Pregnancy: Evidence for Leptin Resistance." In BASIC/TRANSLATIONAL - Influences on Programming of Neuroendocrine Pathways. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part3.p28.p3-242.

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