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Journal articles on the topic 'Propionic acid accumulation'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Feliz, Brady, David R. Witt, and Brent T. Harris. "Propionic Acidemia: A Neuropathology Case Report and Review of Prior Cases." Archives of Pathology & Laboratory Medicine 127, no. 8 (2003): e325-e328. http://dx.doi.org/10.5858/2003-127-e325-paancr.

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Abstract Propionic acidemia is a disorder of branch-chain amino acid and odd-chain fatty acid metabolism. The clinical features typically begin shortly after birth, with rare cases presenting in young adulthood. This disorder most commonly is characterized by episodic decompensations with dehydration, lethargy, nausea, and vomiting as well as a risk for neurologic sequelae. The defect is in the propionyl-CoA carboxylase enzyme with a resultant accumulation of toxic organic acid metabolites. Neuropathologic findings in this inborn error of metabolism have not been extensively characterized but

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2

Inanc, B., S. Matsui, and S. Ide. "Propionic acid accumulation and controlling factors in anaerobic treatment of carbohydrate: effects of H2 and pH." Water Science and Technology 34, no. 5-6 (1996): 317–25. http://dx.doi.org/10.2166/wst.1996.0566.

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Propionic acid is believed to be the most retardative volatile acid appearing in the anaerobic treatment process. However, the mechanisms by which propionic acid accumulates have not been well understood. Several studies and thermodynamical calculations suggest that an increased hydrogen partial pressure in the system is the cause for the accumulation of propionic acid. However, recent findings by the authors and a few other researchers indicated that artificially elevated or reduced hydrogen partial pressure had no discernible effect. Hence, the consensus on the inhibitory effects of hydrogen

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3

He, Dao-Yao, Yoshiaki Yazaki, Yoko Nishizawa, et al. "Gene Activation by Cytoplasmic Acidification in Suspension-Cultured Rice Cells in Response to the Potent Elicitor, N-Acetylchitoheptaose." Molecular Plant-Microbe Interactions® 11, no. 12 (1998): 1167–74. http://dx.doi.org/10.1094/mpmi.1998.11.12.1167.

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N-Acetylchitoheptaose strongly induces a set of defense reactions in suspension-cultured rice cells including cytoplasmic acidification (K. Kuchitsu, Y. Yazaki, K. Sakano, and N. Shibuya, Plant Cell Physiol. 38:1012-1018, 1997) and the accumulation of mRNAs for two rapidly activated genes, EL2 and EL3 (E. Minami, K. Kuchitsu, D.-Y. He, H. Kouchi, N. Midoh, Y. Ohtsuki, and N. Shibuya, Plant Cell Physiol. 37:563-567, 1996), as well as phenylalanine ammonia-lyase (PAL), chitinase and β-1,3-glucanase. Treatment of cells with propionic acid resulted in the accumulation of the mRNAs for EL2, EL3, an

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4

Brass, E. P., P. V. Fennessey, and L. V. Miller. "Inhibition of oxidative metabolism by propionic acid and its reversal by carnitine in isolated rat hepatocytes." Biochemical Journal 236, no. 1 (1986): 131–36. http://dx.doi.org/10.1042/bj2360131.

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The present study was designed to study the interaction of propionic acid and carnitine on oxidative metabolism by isolated rat hepatocytes. Propionic acid (10 mM) inhibited hepatocyte oxidation of [1-14C]-pyruvate (10 mM) by 60%. This inhibition was not the result of substrate competition, as butyric acid had minimal effects on pyruvate oxidation. Carnitine had a small inhibitory effect on pyruvate oxidation in the hepatocyte system (210 +/- 19 and 184 +/- 18 nmol of pyruvate/60 min per mg of protein in the absence and presence of 10 mM-carnitine respectively; means +/- S.E.M., n = 10). Howev

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5

Kido, Jun, Shirou Matsumoto, and Kimitoshi Nakamura. "Carglumic Acid Contributes to a Favorable Clinical Course in a Case of Severe Propionic Acidemia." Case Reports in Pediatrics 2020 (March 9, 2020): 1–5. http://dx.doi.org/10.1155/2020/4709548.

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Propionic acidemia (PA) is manifested as an abnormal accumulation of propionic acid and its metabolites, including methylcitrate, 3-hydroxypropionic acid, and propionylglycine, and is caused by a defect of propionyl-CoA carboxylase. PA is complicated by acute life-threatening metabolic crises, which are precipitated by a catabolic state and result in multiple organ failure or even death, if untreated. A neonate with PA recovered from the first metabolic crisis 3 days after birth but developed a second metabolic crisis during the recovery phase. This patient was considered to have severe PA and

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6

Inanc, B., S. Matsui, and S. Ide. "Propionic acid accumulation in anaerobic digestion of carbohydrates: an investigation on the role of hydrogen gas." Water Science and Technology 40, no. 1 (1999): 93–100. http://dx.doi.org/10.2166/wst.1999.0021.

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This paper describes the experimental investigation into the accumulation of propionic acid under artificially lowered or elevated hydrogen gas levels. Vacuum operation at 0.13, 0.5, and 0.75 atm on the headspace of the reactors, and a selective permeable Teflon membrane placed in the liquid phase, were used to provide low hydrogen concentrations. In the elevated hydrogen concentration experiments, first, hydrogen gas (20% H2 + 80% N2) was bubbled into a batch CSTR reactor. Second, purer H2 gas (80% H2 + 20% CO2) was overpressurized at 2 atm in vials. Suspended cultures were used in all the ex

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7

Morland, Cecilie, Anne-Sofie Frøland, Mi Nguyen Pettersen, et al. "Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia." Biochemical Journal 475, no. 4 (2018): 749–58. http://dx.doi.org/10.1042/bcj20170814.

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Propionic acidemia is the accumulation of propionate in blood due to dysfunction of propionyl-CoA carboxylase. The condition causes lethargy and striatal degeneration with motor impairment in humans. How propionate exerts its toxic effect is unclear. Here, we show that intravenous administration of propionate causes dose-dependent propionate accumulation in the brain and transient lethargy in mice. Propionate, an inhibitor of histone deacetylase, entered GABAergic neurons, as could be seen from increased neuronal histone H4 acetylation in the striatum and neocortex. Propionate caused an increa

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8

Kuley, Esmeray, Gulsun Özyurt, Ilyas Özogul, et al. "The Role of Selected Lactic Acid Bacteria on Organic Acid Accumulation during Wet and Spray-Dried Fish-Based Silages. Contributions to the Winning Combination of Microbial Food Safety and Environmental Sustainability." Microorganisms 8, no. 2 (2020): 172. http://dx.doi.org/10.3390/microorganisms8020172.

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Organic acid contents of acidified and fermented fish silages made from gibel carp (Caracius gibelio) and klunzinger’s ponyfish (Equulites klunzingeri) fishes, and from fish processing residues or by-products, were determined and studied. The silages were undertaken in wet and spray-dried fish-based raw-materials for 3 weeks at room temperature (ca. 25 °C). Selected lactic acid bacteria (LAB) of Enterococcus gallinarum, Lactobacillus brevis, Lactobacillus plantarum, Pediococcus acidilactici, and Streptococcus spp. were employed to produce fermented fish-based silages, while acidified silage wa

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9

WANG, L., Q. ZHOU, and F. LI. "Avoiding propionic acid accumulation in the anaerobic process for biohydrogen production." Biomass and Bioenergy 30, no. 2 (2006): 177–82. http://dx.doi.org/10.1016/j.biombioe.2005.11.010.

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10

Espinosa, A., L. Rosas, K. Ilangovan, and A. Noyola. "Effect of trace metals on the anaerobic degradation of volatile fatty acids in molasses stillage." Water Science and Technology 32, no. 12 (1995): 121–29. http://dx.doi.org/10.2166/wst.1995.0473.

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A laboratory UASB reactor was fed with cane molasses stillage at organic loadings from 5 to 21.5 kg COD/m3 d. With an organic load of 17.4 kg COD/m3 d, an accumulation of VFA, principally propionic acid, was observed due to little bioavailability or lack of trace metals (Fe, Ni, Co and Mo). Associated to this, the performance of the UASB reactor was low (44% COD removal efficiency), with an alkalinity ratio above 0.4. The addition of Fe (100 mg/l), Ni (15 mg/l), Co (10 mg/l) and Mo (0.2 mg/l) to the influent reduced significantly the level of propionic acid (5291mg/l to 251 mg/l) and acetic ac

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11

WAJNER, Moacir, Kátia D. SANTOS, Jeanine L. SCHLOTTFELDT, Maureen P. ROCHA, and Clóvis M. D. WANNMACHER. "Inhibition of mitogen-activated proliferation of human peripheral lymphocytes in vitro by propionic acid." Clinical Science 96, no. 1 (1999): 99–103. http://dx.doi.org/10.1042/cs0960099.

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Recurrent infections are common features in patients affected by propionic acidaemia (McKusick 232000) and methylmalonic acidaemia (McKusick 251000). Since these disorders are biochemically characterized by tissue accumulation of propionic acid and methylmalonic acid respectively, it is possible that these compounds may act as immunosuppressants. We therefore investigated the effect of propionate and methylmalonate on cellular growth of human peripheral lymphocytes stimulated in vitro by phytohaemagglutinin, concanavalin A and pokeweed mitogen, a recognized test of cellular immunocompetence. L

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12

Huang, Huagang, Runze Lu, Juan Zhan, Jinsong He, Yong Wang, and Tingxuan Li. "Role of Root Exudates in Cadmium Accumulation of a Low-Cadmium-Accumulating Tobacco Line (Nicotiana tabacum L.)." Toxics 11, no. 2 (2023): 141. http://dx.doi.org/10.3390/toxics11020141.

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Root exudates are tightly linked with cadmium (Cd) uptake by the root and thus affect plant Cd accumulation. A hydroponic experiment was carried out to explore the role of root exudates in Cd accumulation of a low-Cd-accumulating tobacco line (RG11) compared with a high-Cd- accumulating tobacco line (Yuyan5). Greater secretion of organic acids and amino acids by the roots was induced by an exogenous Cd addition in the two tobacco lines. The concentration of organic acid secreted by RG11 was only 51.1~61.0% of that secreted by Yuyan5. RG11 roots secreted more oxalic acid and acetic acid and les

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13

Wang, Yingxue, Bridgette A. Christopher, Kirkland A. Wilson, et al. "Propionate-induced changes in cardiac metabolism, notably CoA trapping, are not altered by l-carnitine." American Journal of Physiology-Endocrinology and Metabolism 315, no. 4 (2018): E622—E633. http://dx.doi.org/10.1152/ajpendo.00081.2018.

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High concentrations of propionate and its metabolites are found in several diseases that are often associated with the development of cardiac dysfunction, such as obesity, diabetes, propionic acidemia, and methylmalonic acidemia. In the present work, we employed a stable isotope-based metabolic flux approach to understand propionate-mediated perturbation of cardiac energy metabolism. Propionate led to accumulation of propionyl-CoA (increased by ~101-fold) and methylmalonyl-CoA (increased by 36-fold). This accumulation caused significant mitochondrial CoA trapping and inhibited fatty acid oxida

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14

Vuhliar, V., Y. Vuhliar, and I. Syrovatko. "Study of the feeding value of wet corn grain with addition of lactic and propionic acid bacteria." Feeds and Feed Production, no. 99 (June 30, 2025): 161–70. https://doi.org/10.31073/kormovyrobnytstvo202599-14.

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Purpose. To study the main technological parameters of the action of lactic and propionic acid bacteria during the preparation of wet corn grain for long-term storage. Methods. To determine the technological indicators of corn mass maturation during the laying process, it is necessary to use general scientific methods: zootechnical (laying and conducting scientific experiments, establishing the nutritional value of ration feeds), technological, laboratory, chemical analysis of feeds according to generally accepted methods, statistical (biometric materials), analytical. Results. Using lactic ac

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15

Chen, Ying, Kai Liu, Qing Gu, and Min Liu. "Biohydrogen Production Using Anaerobic Fermentation at Various pH Values." Advanced Materials Research 512-515 (May 2012): 570–74. http://dx.doi.org/10.4028/www.scientific.net/amr.512-515.570.

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Hydrogen production with waste water can reduce pollution and produce clean energy at the same time. Hydrogen production is affected by many factors. In this experiment, with automatic fermentor, hydrogen and acid production, as well as organic removal rates from brown sugar wastewater by anaerobic cultures at various pH values, are studied. Results showed that the highest hydrogen production efficiency could be achieved when the pH value was maintained at 6.0. The maximum hydrogen production was 61.1mlH2/(g.VSS.d), and COD removal rate reached up to 33.8%, relatively higher than other pH valu

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16

Fang, Qian, Sinmin Ji, Dingwu Huang, et al. "Impact of Alkaline Pretreatment to Enhance Volatile Fatty Acids (VFAs) Production from Rice Husk." Biochemistry Research International 2019 (January 23, 2019): 1–8. http://dx.doi.org/10.1155/2019/8489747.

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This study explores the use of alkaline pretreatments to improve the hydrolyzation of rice husks to produce volatile fatty acids (VFAs). The study investigated the effects of reagent concentration and pretreatment time on protein, carbohydrates, and dissolved chemical oxygen demand (SCOD) dissolution after the pretreatment. The optimum alkaline pretreatment conditions were 0.30 g NaOH (g VS)−1, with a reaction time of 48 h. The experimental results show that when comparing the total VFA (TVFA) yields from the alkaline-pretreated risk husk with those from the untreated rice husk, over 14 d and

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17

Schwab, Marina A., Sven W. Sauer, Jürgen G. Okun, et al. "Secondary mitochondrial dysfunction in propionic aciduria: a pathogenic role for endogenous mitochondrial toxins." Biochemical Journal 398, no. 1 (2006): 107–12. http://dx.doi.org/10.1042/bj20060221.

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Mitochondrial dysfunction during acute metabolic crises is considered an important pathomechanism in inherited disorders of propionate metabolism, i.e. propionic and methylmalonic acidurias. Biochemically, these disorders are characterized by accumulation of propionyl-CoA and metabolites of alternative propionate oxidation. In the present study, we demonstrate uncompetitive inhibition of PDHc (pyruvate dehydrogenase complex) by propionyl-CoA in purified porcine enzyme and in submitochondrial particles from bovine heart being in the same range as the inhibition induced by acetyl-CoA, the physio

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18

Luo, J., C. S. Ranadheera, S. King, C. A. Evans, and S. K. Baines. "Potential influence of dairy propionibacteria on the growth and acid metabolism of Streptococcus bovis and Megasphaera elsdenii." Beneficial Microbes 8, no. 1 (2017): 111–19. http://dx.doi.org/10.3920/bm2016.0044.

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Ruminal acidosis is a prevalent disorder among dairy cows and feedlot cattle, which can significantly impair their health and productivity. This study, involving seven different strains of dairy propionibacteria, represents an in vitro investigation of the feasibility of using these organisms as direct-fed microbials to control lactic acid acumulation in the rumen. Interactions between the propionibacteria, Streptococcus bovis and Megasphaera elsdenii were evaluated in terms of effects on lactic, acetic and propionic acid metabolism, following co-incubation. Spot resistance tests showed slight

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19

Valentin, Henry E., Timothy A. Mitsky, Debbie A. Mahadeo, Minhtien Tran, and Kenneth J. Gruys. "Application of a Propionyl Coenzyme A Synthetase for Poly(3-Hydroxypropionate-co-3-Hydroxybutyrate) Accumulation in Recombinant Escherichia coli." Applied and Environmental Microbiology 66, no. 12 (2000): 5253–58. http://dx.doi.org/10.1128/aem.66.12.5253-5258.2000.

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ABSTRACT The genetic operon for propionic acid degradation inSalmonella enterica serovar Typhimurium contains an open reading frame designated prpE which encodes a propionyl coenzyme A (propionyl-CoA) synthetase (A. R. Horswill and J. C. Escalante-Semerena, Microbiology 145:1381–1388, 1999). In this paper we report the cloning of prpE by PCR, its overexpression in Escherichia coli, and the substrate specificity of the enzyme. When propionate was utilized as the substrate for PrpE, a Km of 50 μM and a specific activity of 120 μmol Ã¯Â¿Â½ min−1 Ã¯Â¿Â½ mg−1 were found at the saturating substrate

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20

Capson-Tojo, Gabriel, Diane Ruiz, Maxime Rouez, et al. "Accumulation of propionic acid during consecutive batch anaerobic digestion of commercial food waste." Bioresource Technology 245 (December 2017): 724–33. http://dx.doi.org/10.1016/j.biortech.2017.08.149.

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21

Banks, Charles, Yue Zhang, Ying Jiang, and Sonia Heaven. "Trace element requirements for stable food waste digestion at elevated ammonia concentrations." Bioresource Technology 104, no. 2012 (2012): 127–35. https://doi.org/10.1016/j.biortech.2011.10.068.

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The work investigated why anaerobic digesters treating food waste and operating at high ammonia concentrations suffer from propionic acid accumulation which may result in process failure. The results showed deficiency of selenium, essential for both propionate oxidation and syntrophic hydrogenotrophic methanogenesis, leads to this while supplementation allows operation at substantially higher organic loading rates (OLR). At high loadings cobalt also becomes limiting, due to its role either in acetate oxidation in a reverse Wood-Ljungdahl pathway or in hydrogenotrophic methanogenesis. Populatio

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22

Bordugo, Andrea, Elisa Salvetti, Giulia Rodella, et al. "Assessing Gut Microbiota in an Infant with Congenital Propionic Acidemia before and after Probiotic Supplementation." Microorganisms 9, no. 12 (2021): 2599. http://dx.doi.org/10.3390/microorganisms9122599.

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Propionic Acidemia (PA) is a rare inherited metabolic disorder caused by the enzymatic block of propionyl-CoA carboxylase with the consequent accumulation of propionic acid, which is toxic for the brain and cardiac cells. Since a considerable amount of propionate is produced by intestinal bacteria, interest arose in the attempt to reduce propionate-producing bacteria through a monthly antibiotic treatment of metronidazole. In the present study, we investigated the gut microbiota structure of an infant diagnosed at 4 days of life through Expanded Newborn Screening (NBS) and treated the child fo

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23

ZAGRODNIK, ROMAN, and RYSTYNA SEIFERT. "Direct Fermentative Hydrogen Production from Cellulose and Starch with Mesophilic Bacterial Consortia." Polish Journal of Microbiology 69, no. 1 (2020): 109–20. http://dx.doi.org/10.33073/pjm-2020-015.

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Hydrogen produced from lignocellulose biomass is deemed as a promising fuel of the future. However, direct cellulose utilization remains an issue due to the low hydrogen yields. In this study, the long-term effect of inoculum (anaerobic sludge) heat pretreatment on hydrogen production from untreated cellulose and starch was evaluated during repeated batch processes. The inoculum pretreatment at 90°C was not sufficient to suppress H2 consuming bacteria, both for starch and cellulose. Although hydrogen was produced, it was rapidly utilized with simultaneous accumulation of acetic and propionic a

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24

Guo, Jingling, Pan Wang, Yifan Cui, Xiaosong Hu, Fang Chen, and Chen Ma. "Protective Effects of Hydroxyphenyl Propionic Acids on Lipid Metabolism and Gut Microbiota in Mice Fed a High-Fat Diet." Nutrients 15, no. 4 (2023): 1043. http://dx.doi.org/10.3390/nu15041043.

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Gut microbiota imbalances lead to the pathogenesis of non-alcoholic fatty liver disease (NAFLD), which is primarily accompanied by hepatic steatosis. Hydroxyphenyl propionic acids (HPP) have shown great potential in inhibiting lipid accumulation but their protective effects concerning NAFLD and intestinal microbiota have remained unclear. In this paper, we investigated the efficacies of 3-HPP and 4-HPP on hepatic steatosis and gut flora in mice fed a high-fat diet (HFD). We found that 3-HPP and 4-HPP administration decreased body weight and liver index, ameliorated dyslipidemia, and alleviated

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25

García-Molina, Pablo, José Luis Munoz-Munoz, Joaquin A. Ortuño, et al. "Considerations about the Continuous Assay Methods, Spectrophotometric and Spectrofluorometric, of the Monophenolase Activity of Tyrosinase." Biomolecules 11, no. 9 (2021): 1269. http://dx.doi.org/10.3390/biom11091269.

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With the purpose to obtain the more useful tyrosinase assay for the monophenolase activity of tyrosinase between the spectrofluorometric and spectrophotometric continuous assays, simulated assays were made by means of numerical integration of the equations that characterize the mechanism of monophenolase activity. These assays showed that the rate of disappearance of monophenol (VssM,M) is equal to the rate of accumulation of dopachrome (VssM,DC) or to the rate of accumulation of its oxidized adduct, originated by the nucleophilic attack on o-quinone by a nucleophile such as 3-methyl-2-benzoth

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26

Li, Xiang, Yinguang Chen, Shu Zhao, Dongbo Wang, Xiong Zheng, and Jingyang Luo. "Lactic acid accumulation from sludge and food waste to improve the yield of propionic acid-enriched VFA." Biochemical Engineering Journal 84 (March 2014): 28–35. http://dx.doi.org/10.1016/j.bej.2013.12.020.

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27

Li, Hongli, and Yan Wang. "The effect of propionic acid accumulation on methane production in dry mesophilic anaerobic fermentation." IOP Conference Series: Earth and Environmental Science 675, no. 1 (2021): 012208. http://dx.doi.org/10.1088/1755-1315/675/1/012208.

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Kida, Kenji, Shigeru Morimura, and Yorikazu Sonoda. "Accumulation of propionic acid during anaerobic treatment of distillery wastewater from barley-Shochu making." Journal of Fermentation and Bioengineering 75, no. 3 (1993): 213–16. http://dx.doi.org/10.1016/0922-338x(93)90118-r.

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Ma, Junyi, Junting Pan, Ling Qiu, Quan Wang, and Zengqiang Zhang. "Biochar triggering multipath methanogenesis and subdued propionic acid accumulation during semi-continuous anaerobic digestion." Bioresource Technology 293 (December 2019): 122026. http://dx.doi.org/10.1016/j.biortech.2019.122026.

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30

Gallert, C., and J. Winter. "Propionic acid accumulation and degradation during restart of a full-scale anaerobic biowaste digester." Bioresource Technology 99, no. 1 (2008): 170–78. http://dx.doi.org/10.1016/j.biortech.2006.11.014.

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Choi, Jong-il, and Sang Yup Lee. "High-Level Production of Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) by Fed-Batch Culture of Recombinant Escherichia coli." Applied and Environmental Microbiology 65, no. 10 (1999): 4363–68. http://dx.doi.org/10.1128/aem.65.10.4363-4368.1999.

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ABSTRACT Fermentation strategies for production of high concentrations of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(3HB-co-3HV)] with different 3-hydroxyvalerate (3HV) fractions by recombinantEscherichia coli harboring the Alcaligenes latus polyhydroxyalkanoate biosynthesis genes were developed. Fed-batch cultures of recombinant E. coli with the pH-stat feeding strategy facilitated production of high concentrations and high contents of P(3HB-co-3HV) in a chemically defined medium. When a feeding solution was added in order to increase the glucose and propionic acid concentrations to 20 g

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Boyarineva, I. V., and I. S. Khamagaeva. "Nutritional and protective environmental factors for microbial consortium cultivation." Proceedings of the Voronezh State University of Engineering Technologies 84, no. 4 (2023): 96–102. http://dx.doi.org/10.20914/2310-1202-2022-4-96-102.

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Currently, the use of highly active probiotic strains for obtaining consortia with high biochemical and technological potential is relevant and promising in the dairy industry. Such probiotic microorganisms include propionic acid bacteria and Acidophilus bacillus. The creation of a consortium based on Propionibacterium freudenreichii Sh 85 and L. acidophilus makes it possible to develop specialized food products and biologically active additives with high probiotic properties. An inoculate was obtained based on pure cultures of Propionibacterium freudenreichii Sh 85 and L. acidophilus in a rat

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Furkan Kızılsoy, Ömer, Didar Arslan, Ahmet Burak Civan, Murat Tutanç, and Gaffari Tunç. "A case of propionic acidemia during late infancy presenting with metabolic acidosis." Pediatric Academic Case Reports 3, no. 2 (2024): 32–35. https://doi.org/10.61107/pacr.2024.119.

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Propionic acidemia is a disorder of amino acid metabolism caused by propionyl-CoA carboxylase deficiency, which results in the accumulation of propionic acid. It is inherited in an autosomal recessive manner, and its incidence has increased in areas like our country, Türkiye, where consanguineous marriages are common. During exacerbations, patients may demonstrate hyperammonemia, metabolic acidosis, and hyperglycinemia, as well as increased levels of methyl citrate, 3-OH propionate, and propionylglycine. While the disease may have an asymptomatic course, it may present with poor feeding, failu

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34

Guerra, P., G. Villano, M. G. Ruvoletto, et al. "1-Piperidine propionic acid is effective in reducing HCC development and fatty acid accumulation in experimental liver carcinogenesis." Digestive and Liver Disease 56 (February 2024): S15. http://dx.doi.org/10.1016/j.dld.2024.01.024.

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Wang, L., Q. Zhou, and G. H. Zheng. "Comprehensive Analysis of the Factors for Propionic Acid Accumulation in Acidogenic Phase of Anaerobic Process." Environmental Technology 27, no. 3 (2006): 269–76. http://dx.doi.org/10.1080/09593332708618640.

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Shanableh, A., and S. Jones. "Production and transformation of volatile fatty acids from sludge subjected to hydrothermal treatment." Water Science and Technology 44, no. 10 (2001): 129–35. http://dx.doi.org/10.2166/wst.2001.0600.

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The production of useful organic matter from sludge expands the potential for utilizing the product as a resource. This paper is focused on the accumulation and removal of volatile fatty acids (VFAs) produced from primary, secondary and a mixture of both sludges using hydrothermal treatment with and without the use of oxidants. The results confirmed that the maximum accumulation of VFAs was achieved at moderate hydrothermal treatment temperatures below 200°C, and was dependent on the composition of sludge and the amount of oxidant used for treatment. The maximum accumulation reached 0.26-0.36

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37

Wang, Linlin, Ting Jiao, Qiangqing Yu, et al. "Bifidobacterium bifidum Shows More Diversified Ways of Relieving Non-Alcoholic Fatty Liver Compared with Bifidobacterium adolescentis." Biomedicines 10, no. 1 (2021): 84. http://dx.doi.org/10.3390/biomedicines10010084.

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The occurrence of non-alcoholic fatty liver disease (NAFLD) is closely related to intestinal microbiota disturbance, and probiotics has become a new strategy to assist in alleviating NAFLD. In order to investigate the effect of Bifidobacterium on NAFLD and the possible pathway, a NAFLD model was established by using a high-fat diet (HFD) for 18 weeks. Fourteen strains of Bifidobacterium were selected (seven Bifidobacterium adolescentis and seven Bifidobacterium bifidum) for intervention. The effects of different bifidobacteria on NAFLD were evaluated from liver cell injury, liver fat depositio

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Borowski, Sebastian, and Marcin Kucner. "The use of sugar beet pulp stillage for co-digestion with sewage sludge and poultry manure." Waste Management & Research 37, no. 10 (2019): 1025–32. http://dx.doi.org/10.1177/0734242x19838610.

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The anaerobic mesophilic co-digestion of sugar beet pulp stillage with poultry manure and municipal sewage sludge was investigated in this study. The sugar beet pulp stillage (SBPS) mono-digestion failed owing to an accumulation of volatile fatty acids, leading to a pH value lower than 5.5. A 20% addition of poultry manure to stillage allowed for stable digestion performance despite high volatile fatty acid (total volatile fatty acids) concentrations of 5500–8500 g m−3 with propionic acid being the predominant one and constituting 72%–76% total volatile fatty acids. For this mixture, the maxim

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Lahey, Katherine A., Rongcai Yuan, Jacqueline K. Burns, Peter P. Ueng, L. W. Timmer, and Kuang-Ren Chung. "Induction of Phytohormones and Differential Gene Expression in Citrus Flowers Infected by the Fungus Colletotrichum acutatum." Molecular Plant-Microbe Interactions® 17, no. 12 (2004): 1394–401. http://dx.doi.org/10.1094/mpmi.2004.17.12.1394.

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Colletotrichum acutatum infects citrus petals and induces premature fruit drop and the formation of persistent calyces. The accumulation of hormones and other growth regulators, and differential gene expression in affected flowers and young fruit, was examined following fungal infection. Ethylene evolution increased threefold and indole-3-acetic acid (IAA) accumulation was as much as 140 times. Abscisic acid (ABA) levels showed no significant response. After infection, both trans- and cis-12-oxo-phytodienoic acid increased 8- to 10-fold. No significant difference of trans-jasmonic acid (JA) wa

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Бояркин, В. С., И. Г. Капица, and Т. А. Воронина. "Experimental modeling of autism spectrum disorders using propionic acid." Nauchno-prakticheskii zhurnal «Patogenez» 21, no. 4 (2023): 32–38. http://dx.doi.org/10.25557/2310-0435.2023.04.32-38.

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Расстройства аутистического спектра (РАС) – расстройство развития нервной системы, характеризующееся, наряду с нарушением социального общения, стереотипным или повторяющимся поведением и умственной отсталостью разной степени, а также чрезмерной пролиферацией глии, нейровоспалением, нарушением нейронной сети, желудочно-кишечными симптомами и др. Считается, что РАС является результатом взаимодействия генетической предрасположенности, неблагоприятных воздействий окружающей среды и нарушений иммунной системы матери в ранний период беременности. Определенную роль в развитии РАС играет и дисбиоз киш

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REN, Nanqi. "Mechanism and controlling strategy of the production and accumulation of propionic acid for anaerobic wastewater treatment." Science in China Series B 45, no. 3 (2002): 319. http://dx.doi.org/10.1360/02yb9041.

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Selim, Shawky, Sandrine Delacour, and Jaime Schwencke. "Specific long-chain fatty acids promote optimal growth of Frankia : accumulation and intracellular distribution of palmitic and propionic acid." Archives of Microbiology 165, no. 4 (1996): 252–57. http://dx.doi.org/10.1007/s002030050323.

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Прилуцкая, В. А., А. В. Сукало, Т. А. Деркач, et al. "Propionic Acidemia in Children: Literature Review and Clinical Observation." Педиатрия. Восточная Европа, no. 1 (May 11, 2020): 92–105. http://dx.doi.org/10.34883/pi.2020.8.1.008.

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Пропионовая ацидемия редкое наследственное заболевание обмена веществ с аутосомно-рецессивным типом наследования, которое связано с нарушением метаболизма органических кислот. Заболевание обусловлено недостаточностью фермента пропионил-КоА карбоксилазы, которая приводит к накоплению в органах и тканях пропионовой кислоты и ее метаболитов. Клинически выделяют 2 основные формы болезни: острую неонатальную и младенческую (или позднюю) формы. Диагностика заболевания является сложной задачей, так как клинические симптомы, обусловленные дефектами метаболизма, часто встречаются при внутриутробных инф

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Li, Jiang, Yunhui Lei, Xiaodong Pu, Yi Liu, and Ya Tang. "Influence pathway of iron ions with different valences for methane fermentation of vegetable waste." Journal of Renewable and Sustainable Energy 14, no. 4 (2022): 043101. http://dx.doi.org/10.1063/5.0100289.

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Anaerobic digestion (AD) is a promising approach for vegetable waste (VW) recycling and energy recovery but methanogenesis is always inhibited by acid accumulation. The addition of a mixture of iron and other elements has proved effective on reducing acid inhibition during AD of VW, but the effect of use of iron alone has rarely been assessed. In the present study, we compared the effects of Fe0 and Fe2+ on methane fermentation from VW at an organic loading rate of 1.5 gVS/L/d. The results indicated that Fe0 maintained a pH > 7.7, oxidation reduction potential <−520, and methane producti

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Han, Ge, Jie Yu, Jun He, Ping Zheng, Xiangbing Mao, and Bing Yu. "Subtherapeutic Kitasamycin Promoted Fat Accumulation in the Longissimus Dorsi Muscle in Growing–Finishing Pigs." Animals 14, no. 7 (2024): 1057. http://dx.doi.org/10.3390/ani14071057.

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Kitasamycin (KM), a broad—spectrum macrolide antibiotic, has implications for growth performance and residue in animals and humans. This study aimed to explore the effects of different KM doses on intramuscular fat accumulation, cecal microflora, and short—chain fatty acids (SCFAs) using a growing–finishing pig model. Forty—two pigs were divided into three groups: control, subtherapeutic KM (50 mg/kg, KM50), and therapeutic KM (200 mg/kg, KM200) diets over 8 weeks. KM50 led to increased back fat thickness, fat content in the longissimus dorsi muscle (LM), and elevated plasma total cholesterol

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Vieira-Makings, E., N. Chetty, S. C. Reavis, and J. Metz. "Methylmalonic acid metabolism and nervous-system fatty acids in cobalamin-deficient fruit bats receiving supplements of methionine, valine and isoleucine." Biochemical Journal 275, no. 3 (1991): 585–90. http://dx.doi.org/10.1042/bj2750585.

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Cobalamin neuropathy was produced in Cape fruit bats (Rousettus aegyptiacus) by a cobalamin-free diet combined with intermittent exposure to nitrous oxide, which inactivates cobalamin. Cobalamin-deficient bats had low hepatic methylmalonyl-CoA mutase holoenzyme activity, with elevated plasma and urinary methylmalonic acid levels. No significant changes could be demonstrated in the concentration of odd- or branched-chain fatty acids in the nervous system. Supplementation of the cobalamin-free diet with methionine, valine or isoleucine delayed the onset of neuropathy, despite persistence of meth

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Feldman, G. M., F. N. Ziyadeh, J. W. Mills, G. W. Booz, and A. Kleinzeller. "Propionate induces cell swelling and K+ accumulation in shark rectal gland." American Journal of Physiology-Cell Physiology 257, no. 2 (1989): C377—C384. http://dx.doi.org/10.1152/ajpcell.1989.257.2.c377.

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Small organic anions have been reported to induce cell solute accumulation and swelling. To investigate the mechanism of swelling, we utilized preparations of rectal gland cells from Squalus acanthias incubated in medium containing propionate. Propionate causes cells to swell by diffusing across membranes in its nonionic form, acidifying cell contents, and activating the Na+-H+ antiporter. The Na+-H+ exchange process tends to correct intracellular pH (pHi), and thus it maintains a favorable gradient for propionic acid diffusion and allows propionate to accumulate. Activation of the Na+-H+ anti

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Yang, Lingshuang, Xinqiang Xie, Ying Li, et al. "Evaluation of the Cholesterol-Lowering Mechanism of Enterococcus faecium Strain 132 and Lactobacillus paracasei Strain 201 in Hypercholesterolemia Rats." Nutrients 13, no. 6 (2021): 1982. http://dx.doi.org/10.3390/nu13061982.

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Hypercholesterolemia can cause many diseases, but it can effectively regulated by Lactobacillus. This study aimed to evaluate the cholesterol-lowering mechanism of Enterococcus faecium strain 132 and Lactobacillusparacasei strain 201. These results showed that both the strains decreased serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), liver TC and TG and increased fecal TC, TG and total bile acid (TBA) levels. Additionally, both strains also reduced glutamic-pyruvic transaminase (ALT), glutamic oxaloacetic transaminase (AST) and levels of tissue in

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Jiménez-Páez, Elena, Antonio Serrano, Rafael Hueso, Fernando G. Fermoso, and Juan Cubero-Cardoso. "Evaluation of Semi-Continuous Anaerobic Fermentation of Alperujo by Methanogenesis Inhibition." Processes 13, no. 3 (2025): 600. https://doi.org/10.3390/pr13030600.

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Two methanogenesis inhibition strategies for enhancing volatile fatty acid (VFA) production through the anaerobic fermentation of alperujo, a byproduct of olive oil production, were evaluated. Methanogenesis inhibition was implemented via two different approaches, one by pH adjustment to 5.0 and another one by chemical inhibition using 2-bromoethanesulfonate (BES) at pH 7. The VFA accumulation at the end of the experiment was 67% higher under the BES condition than under the pH 5 condition. Interestingly, the VFA profiles were similar under both conditions, with acetic acid as the dominant pro

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Fan, Zijing, Mei Zhang, Xiaxia Chen, et al. "Effects of Lighter Dose of Oxytetracycline on the Accumulation and Degradation of Volatile Fatty Acids in the Process of Thermophilic Anaerobic Digestion of Swine Manure." Sustainability 13, no. 7 (2021): 4014. http://dx.doi.org/10.3390/su13074014.

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Oxytetracycline (OTC) is a commonly used antibiotic in livestock farming for controlling intestinal and respiratory infections in farm animals. However, the absorption of antibiotics by animals is limited, and most antibiotics are excreted in the original form with manure, which will have an impact on the environment. The removal of antibiotics from swine manure could generally be performed via anaerobic digestion (AD). In this study, the effect of oxytetracycline (OTC) at doses of 0.1, 0.5, and 1.0 mg/L on the thermophilic anaerobic digestion of swine manure (55 °C) in batch digesters was stu

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