To see the other types of publications on this topic, follow the link: Prose. eng.
Dissertations / Theses on the topic 'Prose. eng'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 dissertations / theses for your research on the topic 'Prose. eng.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
1
Volante, Paula Aparecida. "A prosa poética de Tutaméia /." Araraquara : [s.n.], 2006. http://hdl.handle.net/11449/91600.
Full textAbstract:
Orientador: Guacira Marcondes Machado Leite<br>Banca: Maria Célia de Moraes Leonel<br>Banca: Glória Carneiro do Amaral<br>Resumo: Este trabalho propõe a estudar a poesia nos contos de Tumatéia de Guimarães Rosa, mostrando as características que o texto apresenta e como se utiliza de elementos poéticos para criar um mundo amplo e particular, tomando pelo perigo e pelo mistério, onde vaga um homem incompleto, que busca a verdade e a unidade, e que deseja compreender o mundo que o rodeia. Essa realidade é criada a partir de um trabalho é criada a partir de um trabalho cuidadoso com a linguagem, que é renovada e reinventada, para renascer plena de significação. Os contos de Rosa transcendem os limites da prosa poética e invadem as fronteiras da narrativa poética, para criar um conto poético que ultrapassa a barreira do tempo e chega à atemporalidade do instante primordial. Assim, os contos de Tutaméia têm o objetivo de iniciar uma revolução no ser e encaminhá-lo rumo à sabedoria, transformando sua visão de mundo e saciando sua fome de poesia.<br>Résumé: Ce travail se propose d'étudier la poésie dans les contes de Tutaméia de Guimarães Rosa, montrant les caractéristiques que le texte présente et la façon dont il utilise des élements poétiques pour créer un monde ample et particulier, plein de périls et de mystères, où vague un homme incomplet, qui cherche sa vérité et son unité, et que désire comprendre le monde qui l'entoure. Cette réalité est crééa à partir d'un travail attentif avec le langage, qui est renouvelé et reincenté pour renaître plein de significations. Les contes de Rosa surpassent les limites de la prose poétique et envahisssent les frontières du récit poétique, pour créer un conte poétique qui dépasse les barrières du temps et arrive à a durée de l'instant primordial. De cete façon, les contes de Guimarães Rosa on l'objectif de commencer une révolution dans l'être pour le conduire à la sagesse, transformant sa vision du monde et rassiant sa faim de poésie.<br>Mestre
2
Beijo, Marilda. "Da criação à recriação : o percurso intertextual e metalinguístico em O ano da morte de Ricardo Reis, de José Saramago /." Assis : [s.n.], 2005. http://hdl.handle.net/11449/94111.
Full textAbstract:
Orientador: Odil José de Oliveira Filho<br>Banca: Sandra Aparecida Ferreira<br>Banca: Suely Fadul Villibor Flory<br>Resumo: O presente estudo propõe uma análise do processo criativo de construção literária desenvolvido na narrativa O ano da morte de Ricardo Reis, de José Saramago, tendo como base a intertextualidade e a metalinguagem que sustentam a questão primordial da pesquisa: o fato de que parece haver no romance a existência de uma certa tensão entre a prosa e a poesia. Isso se dá, possivelmente, em decorrência da recuperação, por Saramago, das odes do poeta neoclássico Ricardo Reis, heterônimo de Fernando Pessoa, trazendo esses textos para o interior do universo ficcional e causando uma mescla entre os gêneros (prosa/poesia, poesia/prosa), de modo a ser possível questionar, inclusive, como se estabelecem os limites entre os gêneros literários, já que o texto vai se construindo de forma híbrida. Esse tipo de procedimento legitima-se pelo fato do escritor utilizar-se do espaço romanesco, que permite a junção dessas duas formas de manifestação artística e estética: o romance resgata, assimila, transforma, deforma, (des)constrói e reconstrói, por meio do processo intertextual, os diferentes discursos de que se apropria. Além disso, paralelamente, existe uma discussão metalingüística, ou seja, o tratamento das artimanhas da linguagem no momento do ato de escrever, que se instala na narrativa por meio dos diálogos entre Ricardo Reis e Fernando Pessoa. O resultado desse processo literário de recriação da poesia de Fernando Pessoa é, segundo a análise feita, uma revisitação, por parte de Saramago, de toda a tradição clássica, assim como de sua poesia e de sua própria postura frente a literatura.<br>Abstract: The current study proposes an analysis of the creative process of literary construction developed in the narrative The year of Ricardo Reis'death, by José Saramago, having as a base the intertextuality and the metalanguage that support the fundamental issue of the research: the fact that it seems to have the existence of a certain tension between prose and poetry in the novel. That occurs probably resulting from the recuperation, by Saramago, of the odes of the neoclassical poet Ricardo Reis, Fernando Pessoa's heteronymous, bringing these texts to the inside of the fiction universe and causing a mixture between the genres (prose/poetry, poetry/prose) so that it is possible to question, inclusive, if what happens is a poetry in form of prose or a sort of poetic prose, since the text is built itself with a hybrid form. This kind of procedure legitimates itself by the fact that the writer uses the romantic space, what allows the joint of these two ways of artistic and aesthetcs manifestation. The novel ransoms, assimilates, transforms, distorts, constructs, destroys and reconstructs the different speeches which it takes as its own, through the intertextual process. Besides, in a parallel way, there is a metalinguistic discussion, that is, the treatment of the language artifices at the moment of the writing act, that is settled in the narrative through the dialogues between Ricardo Reis and Fernando Pessoa. The outcome of this literary process of Fernando Pessoa's poetry re-creation is a revisit of all the classical tradition by Saramago's part, as well as of his poetry, and his own poetical making, according to the analysis performed.<br>Mestre
3
Souza, Valdir Aparecido de. "Rondônia, uma memória em disputa /." Assis : [s.n.], 2011. http://hdl.handle.net/11449/103127.
Full textAbstract:
Orientador: Antonio Celso Ferreira<br>Banca: Zélia Lopes da Silva<br>Banca: Célia Regina Silveira<br>Banca: Edinaldo Bezerra de Freitas<br>Banca: Marcelo Lapuente Mahl<br>Resumo: Esta pesquisa analisa a construção da memória por meio das representações contidas nos textos da narrativa histórica e da literatura poética do Estado de Rondônia. Para tal empreitada foram selecionadas as obras mais expressivas dos autores situados entre o período de vigência do antigo Território Federal do Guaporé (1943-56), depois Território Federal de Rondônia (1956-81) até a consolidação do atual Estado de Rondônia. A análise está focada no discurso destes autores e revela suas filiações e os seus pareceres. Tal memória fica aqui compreendida enquanto uma construção produzida por uma elite letrada, constituindo assim aspectos de representação enquanto projetos, de diferentes matizes, e que disputam entre si a hegemonia do discurso. Nesse sentido, as imagens das populações tradicionais aparecem delineadas a partir de conceitos estereotipados e marcados por um viés ideológico: a noção de vazio demográfico, as populações indígenas igualadas à natureza e o bandeirante como herói civilizador. Assim, as reflexões apresentadas neste trabalho, tiveram como base a eleição de um conjunto de narrativas em prosa e poesia, como também as imagens representativas dos símbolos de poder. Finalmente esta trajetória procura atravessar o interior dos enunciados, dialogando internamente com suas contradições e apontando para suas continuidades e recorrências.<br>Abstract: This research analyses the construction of the State of Rondônia memory by means of the representations portrayed in the some texts of historical narrative and poetry of local writers. To reach that aim, the most representative works were selected from authors who wrote between the periods: 1943-56 (Guaporé Federal Territory), 1956-81 (Rondônia Federal Territory) up to the consolidation of the Rondônia State, after 1981. The analysis focuses these authors' speeches and reveals their political affiliation and places from where they spoke their feelings - such memory is understood as product of highly educated elite which builds up projects of representation aspects, of different kinds, which fight each other the speech control. In this sense, the local images of the traditional populations appear designed from stereotyped misconceptions and ideologically biased: the notion of demographic emptiness, the rainforest populations leveled to nature and the "bandeirante" as a civilizing hero. Thus, the reflections presented in this work, had had as base the election of a set of narratives in prose and poetry, as well as the representative images of the symbols of being able. Finally, this trajectory seeks to go through the inside of enunciation, dialoguing internally with its contradictions and pointing with respect to its continuities and recurrences.<br>Doutor
4
Kaimoti, Ana Paula Macedo Cartapatti. "Ossos e espelhos mortos : uma leitura de Reflexos do baile e Esqueleto na lagoa verde, de Antonio Callado /." São José do Rio Preto : [s.n.], 2007. http://hdl.handle.net/11449/106320.
Full textAbstract:
Orientador: Marcos Antonio Siscar<br>Banca: Arnaldo Franco Júnior<br>Banca: Orlando Amorim<br>Banca: Jaime Ginzburg<br>Banca: Fábio A. Durão<br>Resumo: Neste trabalho, investigamos os modos como a reportagem Esqueleto na lagoa verde (1953) e o romance Reflexos do baile (1976), de Antonio Callado, instauram um impasse entre seu projeto realista de narrativa e a forma fragmentária da escrita. Buscando compor um retrato do Brasil no qual a história recente do país aparece em primeiro plano, a obra romanesca de Callado foi freqüentemente vinculada à carreira de jornalista que o escritor também desenvolveu. Nesse sentido, ao mesmo tempo em que se pode constatar a influência que o apego ao universo factual exerceu sobre sua ficção, se deve também destacar o confronto contínuo com a linguagem do jornal, no qual se manifesta a crença do autor na capacidade da literatura em iluminar os fatos de maneira privilegiada, para além da objetividade e da organicidade do discurso jornalístico. Essa confiança no poder revelador da ficção já aparece subrepticiamente no desejo do repórter de esclarecer o mistério que envolve a constituição do Brasil, narrando sua expedição ao Xingu, em Esqueleto na lagoa verde; ela também está na maneira como o escritor fragmenta Reflexos do Baile com o intuito de tornar sensível a violência que predominava no país, no decorrer da década de 70; e está ainda na tentativa do cronista Callado de buscar, em sua memória literária, o entendimento dos fatos jornalísticos e históricos da contemporaneidade, em Crônicas de fim do milênio (1997). Em Esqueleto na lagoa verde, a reportagem se multiplica em outras narrativas, incoerentes entre si, e a expedição que a fundamenta não consegue esclarecer nenhum de seus enigmas; em Reflexos do Baile, a fragmentação do romance se radicaliza, desviando-se do objetivo de representar a história da época; e, nas crônicas, a presença da literatura, no lugar de esclarecer os fatos, faz do próprio texto o fato que interessa...(Resumo completo, clicar acesso eletrônico abaixo)<br>Abstract: In this work we have investigated the ways the report Esqueleto na lagoa verde (1953) and the novel Reflexos do baile (1976), by Antonio Callado, initiate an impasse between its narrative realist project and the fragmentary form of writing. By seeking to build a portrait of Brazil, in which the country's recent history comes in the foreground, the novel by Callado has often been linked to the career as journalist also pursued by the writer. While the influence of the attachment to the factual universe may be verified in his fiction, the continuous confrontation with the newspaper language must also be highlighted, wherein the author's belief manifests itself in the ability of literature to illuminate facts in a privileged way beyond the objectivity and organicity of the journalistic discourse. This belief in the revealing power of fiction already surreptitiously appears in the reporter's desire to clarify the mystery involving the constitution of Brazil, by narrating his expedition to the Xingu River in Esqueleto na lagoa verde. It is also in the way the writer fragments Reflexos do Baile, with the purpose of turning the predominant violence in the country in the 70s sensitive, and yet in Callado's attempt to search, in his literary memory, the understanding of contemporary journalistic and historical facts in Crônicas de fim do milênio (1997). In Esqueleto na lagoa verde, the report multiplies itself into other narratives, incoherent between themselves, and the expedition grounding it cannot clarify any of its enigmas; in Reflexos do baile, the fragmentation of the novel becomes radical and stirs away from the goal of representing the history of that period; and, in the chronicles, the presence of literature, instead of clarifying the facts, makes the text itself an interesting fact. Usually considered only stylistic byproducts of a realist project, ...(Complete abstract clik electronic access below)<br>Doutor
5
Cabrini, Júnior Paulo de Tarso. "Uma novela infernal /." Assis : [s.n.], 2002. http://hdl.handle.net/11449/94149.
Full textAbstract:
Orientador: Odil José de Oliveira Filho<br>Banca: Aguinaldo José Gonçalves<br>Banca: José Carlos Zamboni<br>Resumo: As Obras do Diabinho da Mão Furada têm sido um texto polêmico, pela suspeita de que transmite, sob a forma de novela doutrinária católica, uma mensagem contrária a essa mesma doutrina e suas práticas. Escrita em Portugal, no início do século XVIII, mas publicada, no Brasil, apenas em 1861-1862, a novela é atribuída a Antonio José da Silva (1705-1739), autor conhecido por suas peças para teatro de bonecos, nas quais usava satirizar as instituições e os valores morais e sociais de sua época. Cristão-novo, mais conhecido pelo apelido "O Judeu", Antonio José foi preso e torturado, em 1726, por crime de judaísmo. Foi depois dessa primeira prisão que Antonio José passou a escrever e fazer representarem suas peças, como forma "disfarçada" de agressão e resistência ao Tribunal da Inquisição, até ser preso novamente e executado em auto-de-fé, em 1739. Esta dissertação de mestrado se propõe a investigar a mensagem "camuflada" das Obras do Diabinho da Mão Furada, e interpretar a crítica ao Tribunal da Inquisição, disfarçada, textualmente, em apologia da doutrina católica.<br>Abstract: Obras do Diabinho da Mão Furada is a controversial text, because it seems that, under a catholic and doctrinal shape, it transmits a message against that same doctrine and against its practices. The story was written in Portugal, in the beginning of the XVIIIth century, but it was published in Brazil in 1861-1862. Its authorship is imputed to Antonio José da Silva (1705-1739), an author known by his puppet plays, which he used to satirize the institutions, the moral and the social values of his age. Antonio José, better known as "The Jew", was arrested and tortured in 1726, because of jewish practices. After that, he began to write and perform his plays, as a "disguised" form of agression and resistence to the Inquisition, and done it until his last imprisonment and death (1739). The motion of this present work is an investigation of the "disguised" message of the story Obras do Diabinho da Mão Furada, in order to decode the assaults against the Inquisition - assaults textually disguised beneath an eulogy of the catholic doctrine.<br>Mestre
6
Rodrigues, Lucilo Antonio. "A poesia do romance : Memorial de Aires, um caso exemplar /." São José do Rio Preto : [s.n.], 2007. http://hdl.handle.net/11449/106337.
Full textAbstract:
Orientador: Aguinaldo José Gonçalves<br>Banca: Hélio de Seixas Guimarães<br>Banca: Valentim Aparecido Facioli<br>Banca: Sérgio Vicente Motta<br>Banca: Susanna Busato<br>Resumo: Esta tese tem como objetivo principal o estudo da poesia no Memorial de Aires, de Machado de Assis. Em uma primeira etapa buscou-se refletir a questão da poesia no romance no âmbito geral da prosa romanesca: Mikhail Bakhtin refere-se a essa problemática no ensaio "O Discurso no romance". Para ele, a poesia e o romance estariam em campos opostos: enquanto neste se constata uma tendência à fragmentação da linguagem (refletindo, direta ou indiretamente, a estratificação social); naquela, ocorre uma tendência à centralização da linguagem (refletindo os processos sociais mais duráveis). Em razão dessa particularidade a poesia no romance, na grande maioria das vezes, não desempenha um papel de relevo: ou é rechaçada, mediante a ironia, a sátira, a paródia e a análise crítica ou permanece sob a forma de núcleos isolados distribuídos ao longo do texto romanesco. Em alguns casos raros, como no romance Memorial de Aires, a linguagem poética não só é importante enquanto voz isolada, mas também teria uma função determinante na composição geral do estilo deste romance.<br>Abstract: The present dissertation has, as a main target, the study of poetry in Memorial de Aires, by Machado de Assis. In its first part, we tried to reflect on the poetry in the novel, in the general scope of the novelistic prose: Mikhail Bakhtin refers to this subject in his essay "Discourse in novel". As he considers, poetry and novel would be in opposite fields: while in the last one we confirm a tendency to a language breaking up (reflecting, direct or indirectly, the social stratification), in that one, it occurs a tendency to language centralization (reflecting the more durable social processes). Because of this particularity, poetry in novel, in its great majority, doesnt play a relevant role: either it is rejected by irony, satire, parody and critical analysis, or it remains in the form of isolated nucleus, distributed along the novelistic text. In some rare cases, as in the novel Memorial de Aires, the poetic language is not only important as an isolated voice, but also would have a determining function in the general composition style of this novel.<br>Doutor
7
Trentin, Micheline Sandini. "Influência do cálculo subgengival nas medidas de sondagem periodontal com sonda manual e eletrônica de força controlada : estudo em humanos /." Araraquara : [s.n.], 2002. http://hdl.handle.net/11449/104758.
Full textAbstract:
Orientador: Rosemary Adriana Chiérici Marcantonio<br>Banca: Silvana Regina Perez Orrico<br>Banca: Joni Augusto Cirelli<br>Banca: Rui Vicente Opperman<br>Banca: Fábio André dos Santos<br>Resumo: O objetivo deste estudo foi avaliar clinicamente a influência do cálculo subgengival nas medidas de profundidade de sondagem com sonda manual e eletrônica de força controlada. Para tanto, foram avaliados 614 sítios com cálculo subgengival visível em radiografias periapicais e detectáveis clinicamente através do índice de cálculo de Greene e Vermillion, 1967. Os exames foram realizados por um profissional calibrado que avaliou o índice de sangramento gengival à sondagem e realizou a sondagem com os dois tipos de sondas em seis áreas de cada dente: mesio-vestibular, vestibular, disto-vestibular, mesio-lingual, lingual e disto-lingual, com o auxílio de um stent oclusal. As sondagens foram realizadas em dois instantes. Inicial: com a presença do cálculo subgengival, imediato: imediatamente após a remoção do cálculo subgengival. Para a análise dos dados obtidos, as profundidades de sondagens foram estratificadas em rasa (=3mm), média (4-6mm) e profunda (= 7mm). Através do teste de Wilcoxon à 5%, observou-se que as medidas de profundidades de sondagens médias (4.78mm para o momento inicial e 4.56mm para o momento imediato) e profundas (7.60mm para o momento inicial e 6.79 mm para o momento imediato) para a sonda eletrônica de força controlada apresentaram diferenças significativas entre os diferentes momentos, porém, o mesmo não ocorreu quando foi utilizada a sonda manual. Da mesma forma, quando o teste t foi empregado para avaliar a influência do sangramento à sondagem sobre as diferenças da sondagem manual e computadorizada, este não apresentou-se como um fator influenciador. Conclusão: O cálculo subgengival interfere na sondagem realizada com a sonda computadorizada, não ocorrendo o mesmo com a sonda manual.<br>Abstract: The present investigation assessed the influence of subgingival calculus on clinical probing measurements with manual and constant force electronic probe. The study evaluated 614 sites with visible subgingival calculus, evidenced by radiographic and clinical modified index (Greene & Vermillion, 1967). The evaluation was performed by a calibrated dental examiner, who evaluate gingival bleeding index and probing depth with manual and computarized probe, in six sites per tooth: mesio-buccal, middle-buccal, disto-buccal, mesio-lingual, middle-lingual and disto-lingual with individually acrylic stents. The probing depths measurements were performed in two moments. Inicial: In presence of subgingival calculus, immediate: immediately after removal of subgingival calculus. To data analysis, the probing depths measurements were classified in: shallow depths (=3mm), moderate (4-6mm) and deep (=7mm) and submmited to statistical analysis (Wilcoxon 5%). The results show that moderate measurement (4.78mm at inicial moment and 4.56mm for immediate), and deep measurements (7.60mm at inicial moment and 6.79 for immediate) with a computerized probe were statistically differentes significative for two moments, however, the same difference did not occurre when manual probe was used. Smilary, when the test t assessed the influence of gingival bleeding index to detect differences between computarizade and manual probe, this not represent a source of error in this measurement. Conclusion: The subgingival calculus influenced the probing depth measurements when a computarized probe was used, although that didnþt occurre with manual probe.<br>Doutor
8
Nielson, James. "Elizabethan realisms : reading prose from the end of the century." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74597.
Full textAbstract:
This thesis basically has a twofold aim: on the one hand, to make a somewhat neglected body of Renaissance prose more readable, by adding, in a punctual and miscellaneous manner, to our historical, philological and thematic understanding of it and by examining it in the light of some of our current theoretical preoccupations; and, on the other hand, to problematize the "realistic" rubric assigned to these works and to do so by cultivating a more thoroughgoing textual realism on the part of readers.<br>These works, traditionally grouped together because of the interaction of their authors at the end of the 16th century, include Robert Greene's "cony-catching" and "confessional" pamphlets, the texts of the controversy between Thomas Nashe and Gabriel Harvey, and Harvey's manuscript drafts, as well as more familiar works such as Nashe's Unfortunate Traveller.<br>The theoretical issue of "the real" as a textual effect has been divided up according to the three nominal categories of persons, places and things, but the thesis falls methodologically into two halves. The opening chapters aim at reintroducing the figures of Greene, Nashe and Harvey, and exploring the quasi-genres of confession, invective and rough draft as exemplary models of the textual construction of a realistic person. They also attempt an alternative form of reading which is an amalgam of cento, summary, close reading, theoretical aside, and running commentary. In the second half, microreadings of the Marprelate Tracts, the cony-catching pamphlets, and texts by Nashe are used to shed light on theoretical issues of textual "place" such as the rhetorical construction of "presence" and metaphorical "movement." Once the relationship between premodern and postmodern textuality has been sketched, the final chapter offers a critique of the unreflexive academic practice of doing "readings," and argues for a new literalism and the self-subversion of the figurative in an "extrarhetorical" reading of Nashe's Lenten Stuffe.
9
Gomes, Patricia Rodrigues Lourenço. "Efeito da exposição à fumaça de cigarro sobre a expressão de GLUT4 em ratas prenhes e lactantes e sua prole /." Presidente Prudente : [s.n.], 2010. http://hdl.handle.net/11449/87331.
Full textAbstract:
Orientador: Patrícia Monteiro Seraphim<br>Banca: Ismael Forte Freitas Júnior<br>Banca: Cecília Edna Mareze da Costa<br>Resumo: A gravidez é um período de ajustes metabólicos e, quando associado ao tabagismo provoca alterações que trazem malefícios tanto à saúde materna quanto à saúde fetal. Assim, o estudo investigou o efeito da exposição à fumaça de cigarro sobre a expressão do transportador de glicose GLUT4 e parâmetros séricos e morfométricos de ratas prenhes e sua prole. Foram utilizadas ratas Wistar divididas em: CG- controle sacrificadas após a gestação, com prole adotada pelo grupo CL; CL - controle sacrificadas após o término da lactação; FG - expostas à fumaça de cigarro até o período gestacional e sacrificadas posteriormente, com prole adotada pelo grupo FL; FG - expostas à fumaça de cigarro até o fim da amamentação e posteriormente sacrificadas. As proles foram divididas por sexo e de acordo com a exposição ou não da rata à fumaça. Foram coletados sangue e tecidos para análise de glicemia e do conteúdo gênico e protéico de GLUT4. Nas ratas expostas à fumaça de cigarro, houve redução de peso corpóreo e de tecido adiposo, aumento da glicemia e modulação do transportador GLUT4 no músculo esquelético. Nas proles, houve... (Resumo completo, clicar acesso eletrônico abaixo)<br>Abstract: Pregnancy is a period of metabolic adjustments, and when associated with cigarette smoke causes changes both to maternal health as the fetal. The study has investigated the effect of cigarette smoke exposure on the expression of glucose transporter GLUT4 and morphometric parameters and serum of pregnant smoker rats and their offspring. Wistar rats were divided in: CG- nonsmokers sacrificed after pregnancy with offspring adopted by CL; CL - nonsmoker group sacrificed after the end of lactation; FG - smoker group sacrificed after pregnancy with offspring adopted by FL; FL - smoker sacrificed after the end of lactation. The offspring was divided by sex and according to the protocol of their mothers. Blood and tissue were collected for analysis of glucose and the content of GLUT4 gene and protein. In smoker mothers, body weight and adipose tissue were reduced, glucose level was increased, and GLUT4 expression was higher in skeletal muscle. In offspring... (Complete abstract click electronic access below)<br>Mestre
10
Milde, Peter [Verfasser], Lukas M. [Akademischer Betreuer] Eng, and Christian [Akademischer Betreuer] Loppacher. "Visualisation of Local Charge Densities with Kelvin Probe Force Microscopy / Peter Milde. Gutachter: Lukas M. Eng ; Christian Loppacher. Betreuer: Lukas M. Eng." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://d-nb.info/1067189939/34.
Full text
11
Neuber, Erik [Verfasser], Lukas M. [Akademischer Betreuer] Eng, Lukas M. [Gutachter] Eng, and István [Gutachter] Kézsmárki. "Scanning Probe Microscopy Investigation of Multiferroic Materials Hosting Skyrmion Lattices / Erik Neuber ; Gutachter: Lukas M. Eng, István Kézsmárki ; Betreuer: Lukas M. Eng." Dresden : Technische Universität Dresden, 2019. http://d-nb.info/1226942512/34.
Full text
12
Souza, Júnior Geso Batista de. "Jornalismo cultural : os valores-notícia do caderno Prosa & Verso /." Bauru : [s.n.], 2011. http://hdl.handle.net/11449/89427.
Full textAbstract:
Orientador: Mauro de Souza Ventura<br>Banca: José Carlos Marques<br>Banca: Osvando José de Morais<br>Resumo: Explicitamente fundados em determinadas concepções de cultura, os processos de mediação social que conformam o jornalismo cultural nos meios de massa ressaltam alguns acontecimentos em detrimento de muitos outros. A partir de uma concepção do jornalismo cultural contemporâneo enquanto práxis comunicacional, este trabalho investiga a problemática do processo midiático e das práticas socioculturais na cobertura jornalística cultural do suplemento literário Prosa & Verso, do jornal carioca O Globo, durante o período de 2008. Apoiada no instrumental das teorias da notícia e na sociologia da cultura e do jornalismo, esta análise investiga como operam os valores-notícia e que sentido adquirem na prática do jornalismo cultural do suplemento literário Prosa & Verso. A partir de uma análise das reportagens de capa deste caderno literário, examinamos o funcionamento das relações constitutivas do campo da difusão, espaço em que agentes de determinados campos - produtores e intermediários - interferem de maneira estratégica na hierarquia da legitimidade cultural, evidenciando assim tais articulações (in)visíveis no processo de construção da notícia. Ao expor essa temática, esperamos contribuir para as discussões sobre a interação entre o campo literário e o campo jornalístico que são encontradas nas práticas textuais do jornalismo cultural contemporâneo<br>Abstract: Explicity founded on certain notions of culture, the processes of social mediation that shape the cultural journalism in the mass media highlights certain events over others. From a contemporary cultural conception of journalism as practice communication, this dissertation investigates the mediatic process and sociocultural practices in cultural coverage of Prosa & Verso literary supplement, published by newspaper O Globo, in Rio de Janeiro, during all of 2008. Supported by the instrumental theories of news and sociology of culture and journalism, this analysis invetigates how news values operate and acquire meaning in the practice of cultural journalism developed by Prosa & Verso. From an analysis of the cover stories of this literary suplement, examine the operation of the constitutive relations in the field of broadcasting, space in which agents of certain fields - producers and cultural intermediaries - in a strategic way interfere in the hierarchy of cultural legitimacy, thus demonstrating such joints (in) visible in the process of news' construction. By exposing this theme, we hope to contribute to discussions about the interaction between the literary and journalistic fields that are seen in the textual practices of contemporary cultural journalism<br>Mestre
13
Schneider, Marcelo de Oliveira. "Comportamento de cuidado da prole da saúva-limão Atta sexdens rubropilosa Forel, 1908 (Hymenoptera, formicidae) /." Rio Claro : [s.n.], 2003. http://hdl.handle.net/11449/88529.
Full textAbstract:
Orientador: Odair Correa Bueno<br>Banca: Ana Paula Protti de Andrade<br>Banca: Terezinha Maria Castro Della Lucia<br>Resumo: Um conjunto de microcâmeras e aparelhos para gravação e análise de imagens foi usado para observar, descrever e quantificar os comportamentos de cuidado da prole por parte das operárias adultas da saúva-limão Atta sexdens rubropilosa. Para isso foram utilizadas colônias de laboratório com câmaras especialmente projetadas para a observação do ambiente interior do formigueiro, o jardim de fungo. As microcâmeras utilizadas permitiram que os comportamentos fossem vistos com grande riqueza de detalhes, mostrando-se bastante adequadas para observar pequenos objetos como as menores operárias do formigueiro, e comportamentos que ocorrem em uma pequena área como os propostos neste trabalho. A análise do material filmado em fitas de vídeo possibilitou que comportamentos rápidos fossem facilmente observados e que comportamentos que aconteciam simultaneamente fossem analisados independentemente. Foram descritos diversos comportamentos que ocorrem na área da cria, com suas respectivas freqüências, discutindo-se o papel do tamanho e da idade das operárias na divisão de trabalho. As principais categorias de comportamentos de cuidado da prole observados foram: limpeza dos estágios imaturos pelas operárias adultas, o aprovisionamento das larvas e a ocorrência de trofalaxia no interior do formigueiro. Além disso, uma nova forma de transferência de alimento das larvas para as operárias adultas, denominada trofalaxia proctodeal, foi descrita para Atta.<br>Abstract: A set of microcameras and other equipment for recording and image analyses were used to observe, describe and quantify the brood care behaviors of the adult workers of the Lemon Leaf-Cutting Ant Atta sexdens rubropilosa. In order to observe the fungus garden inside the ant colony, laboratory colonies with especially designed observation chambers were used. The microcameras enabled the behaviors to be observed in great detail, proving themselves to be very adequate for the observation of small objects such as the smallest workers, as well as behaviors occurring on a small area as the ones proposed in this work. The analyses of the material recorded on videotapes made it easier to follow fast behaviors and to independently analyze distinct behaviors happening simultaneously. Several behaviors occurring around the brood are described with their respective frequencies. The role of worker age and size on the division of labor are discussed. The main categories of brood care behavior observed were: grooming of the immature stages by the adult workers, larval feeding and the occurrence of trophalaxis in the colony. A new means of food transfer from the larvae to the adult workers, named proctodeal trophalaxis was also described.<br>Mestre
14
Silva, Emílio Barbosa e. "Avaliação clínica e microbiológica de diferentes modalidades de terapia periodontal não-cirúrgica em pacientes com periodontite crônica /." Araraquara : [s.n.], 2004. http://hdl.handle.net/11449/104724.
Full textAbstract:
Orientador: Benedicto Egbert Corrêa de Toledo<br>Banca: Enilson Antônio Sallum<br>Banca: Márcio Fernando de Moraes Grisi<br>Banca: Silvana Regina Perez Orrico<br>Banca: Valdir Gouvêia Garcia<br>Resumo: O objetivo deste estudo foi avaliar em pacientes portadores de periodontite crônica avançada, os efeitos de diferentes modalidades de tratamento periodontal não-cirúrgico na composição microbiana subgengival e nos parâmetros clínicos de avaliação da doença periodontal em diferentes tempos de análise. Foram avaliados 30 pacientes com idade entre 25 e 68 anos com profundidade à sondagem inicial d 6mm e = 8 mm nos sítios selecionados. Estes pacientes foram divididos em três grupos, cada um contendo 10 pessoas de acordo com o tratamento realizado: Grupo 1 - realização de raspagem e alisamento radiculares supra e subgengivais concomitantemente no mesmo dia; Grupo 2 - realização de raspagem alisamento e polimento supragengival e 7 dias após realização de raspagem e alisamento radiculares subgengival; Grupo 3 - realização de raspagem alisamento e polimento somente supragengival por 30 dias e complementação da raspagem subgengival após este período. Os pacientes foram avaliados antes e após 7, 15, 30 e 60 dias de realizado o procedimento inicial pelos seguintes parâmetros clínicos: profundidade de sondagem, nível de inserção, sangramento à sondagem, presença de placa, inflamação gengival e supuração. Também foram realizadas coletas de amostras de placa subgengival nos mesmos sítios e períodos e analisadas a prevalência e os níveis de 36 espécies bacterianas pela técnica do "checkerboard DNA-DNA hybridization". Como resultados deste estudo verificamos que a profundidade de sondagem foi significativamente reduzida pelos tratamentos de raspagem supra e subgengival concomitante e raspagem supra 7 dias prévios a subgengival. O grupo que recebeu somente raspagem supragengival até o 30º dia não apresentou melhora até este período, com uma redução significativa após a complementação da raspagem... (Resumo completo, clicar acesso eletrônico abaixo).<br>Abstract: The purpose of the present investigation was to evaluate the effects of different modalities of non-surgical periodontal treatment in 30 patients with advanced chronic periodontitis. Subjects were monitored clinically and microbiologically prior and 7, 15, 30 and 60 days after this three periodontal treatments: Group 1 - concomitant supra and subgingival scaling and root planning; Group 2 - supragingival scaling 7 days prior to subgingival scaling and root planning; Group 3 - supragingival scaling 30 days prior to subgingival scaling and root planning. Clinical assessment of plaque, redness, suppuration, bleeding on probing, pocket depth and clinical attachment level were made in two anterior teeth per patient. Subgingival plaque samples were taken at the same sites and the presence and levels of 36 subgingival bacteria species were determined using checkerboard DNA-DNA hybridization. The mean levels and % colonized by each species (prevalence) was computed for each subject at each visit. As results of this study was verified that pocket depth was significantly reduced for group 1 and 2. The group that received only supragengival scaling until the 30th day didn't improve until this period, with a significant reduction after the complementation of subgengival scaling and root planning. The clinical attachment level parameter didn't demonstrate significant alteration in none of the three groups along the time. However all the groups showed improvement or stability in this parameter, tends the group 1 presented the best results, followed for the group 2 and 3, respectively. All the groups didn't present differences between the initial period and the times of 30 and 60 days in relation to the other parameters of clinical evaluation, except for the gingival redness that had group 2 with better results, followed for the group 1 and 3... (Complete abstract, click electronic address below).<br>Doutor
15
Piffer, Renata Carolina. "Influência da terapia pré-natal com betametasona sobre o desenvolvimeto da prole, do nascimento à vida adulta reprodutiva, em ratos /." Botucatu : [s.n.], 2009. http://hdl.handle.net/11449/102648.
Full textAbstract:
Orientador: Oduvaldo Câmara Marques Pereira<br>Banca: Daniela Cristina Ceccatto Gerardin<br>Banca: Angelina Zanesco<br>Banca: Célia Regina Nogueira<br>Banca: Marilza Vieira Cunha Rudge<br>Resumo: A corticoterapia vem sendo muito utilizada na prática obstétrica, em gestantes com risco de parto prematuro, no intuito de promover a aceleração da maturidade pulmonar fetal. Entretanto, altos níveis de corticosteróides podem interferir com o pico de testosterona perinatal, importante para a diferenciação sexual do hipotálamo. Este processo é mediado por hormônios gonadais durante o período perinatal e responsável pelas diferenças fisiológicas, morfológicas, comportamentais e neuroanatômicas entre machos e fêmeas adultos. O hipotálamo de mamíferos, antes da diferenciação sexual, está organizado do tipo feminino . No macho, o hipotálamo precisa ser masculinizado e defeminizado para que apareça o padrão tônico de secreção de gonadotrofinas e o comportamento de monta. Desta maneira, objetivouse investigar através de parâmetros reprodutivos, metabólicos, farmacológicos e de biologia molecular, possíveis alterações resultantes da terapia com betametasona no período pré-natal em ratos, avaliando o desenvolvimento dos descendentes machos, do nascimento até a vida adulta reprodutiva. Ratas Wistar prenhes receberam 0,1mg/kg de betametasona (grupo Betametasona) ou salina (grupo Controle) no 12º, 13º, 18º e 19º dias de prenhez (IM). A exposição pré-natal à betametasona reduziu ao nascer a massa corporal e a distância anogenital; o peso úmido da glândula adrenal e a corticosterona plasmática também estavam reduzidos ao nascer em relação ao grupo Controle, indicando comprometimento do eixo hipotálamo-hipófise-adrenal. No entanto, esta terapia não alterou o desenvolvimento físico da prole, exceto pelo atraso na descida testicular. Na vida adulta, a exposição pré-natal à betametasona reduziu o peso úmido do testículo e da secreção da vesícula seminal, bem como a ...(Resumo completo, clicar acesso eletrônico abaixo)<br>Abstract: Corticosteroids are used widely in obstetric clinical practice in pregnant women at risk for preterm delivery. This therapy promotes fetal lung maturation, thus reducing the incidence of respiratory distress syndrome, which in turn decreases neonate mortality and morbidity. In spite of this, much less is known about the interference of high corticosteroid levels at the testosterone peak during the critical period of brain sexual differentiation. Thus, the aim this study was to investigate reproductive, metabolic, pharmacologycal, and molecular biology parameters in male rats exposed prenatally to betamethasone. Pregnant rats received 0.1mg/kg of betamethasone (Betamethasone group) or saline (Control group) on the 12th, 13th, 18th, and 19th days of pregnancy (IM). The prenatal treatment with betamethasone reduced the body weight, the anogenital distance, the wet weight of adrenal, and plasmatic corticosterone level of male pups at birth. However, this terapy did not alter the physical development, but there was retardation in the age of testicular descent. In adulthood, there were reductions in the wet weight of testis, in the seminal vesicle secretion, in the adrenal wet weight and as well as plasmatic corticosterone level. The fertility reduction observed in the Betamethasone group probably was caused by decreased sperm quality, sperm production, and plasmatic testosterone level, and not for alterations in contraction response of seminal vesicle and vas deferens, to autonomic drugs, so important for ejaculatory process. Prenatal exposure to betamethasone also damaged sexual behavior. There was a delay in the latency to first ejaculation, as well as a decrease in the numbers of postejaculatory intromissions, total intromissions and total ejaculations. Although 80% of the betamethasone-treated animals exhibited male sexual behavior, ...(Complete abstract click electronic access below)<br>Doutor
16
Murawski, Jan [Verfasser], Lukas M. [Akademischer Betreuer] Eng, and Björn [Gutachter] Lüssem. "Time-Resolved Kelvin Probe Force Microscopy of Nanostructured Devices / Jan Murawski ; Gutachter: Björn Lüssem ; Betreuer: Lukas M. Eng." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://d-nb.info/1133109640/34.
Full text
17
Murawski, Jan [Verfasser], Lukas M. Akademischer Betreuer] Eng, and Björn [Gutachter] [Lüssem. "Time-Resolved Kelvin Probe Force Microscopy of Nanostructured Devices / Jan Murawski ; Gutachter: Björn Lüssem ; Betreuer: Lukas M. Eng." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-224810.
Full text
18
Macdonald, Gillian E. "Eco-socialism in the early poetry and prose of William Morris." Thesis, University of Dundee, 2015. https://discovery.dundee.ac.uk/en/studentTheses/6ea6f115-0e6b-4585-bb90-cf32a6a1f220.
Full textAbstract:
William Morris was a highly significant political and cultural figure of the nineteenth century. He was a great artist-craftsman and was hugely influential in the rise of the Arts and Crafts Movement in the second half of the nineteenth century, a movement which saw the revival of traditional crafts as a reaction to the utilitarianism of industrial mass production. Already an accomplished artist and writer, Morris became, in the 1880s, a significant figure in the development of the socialist movement. Often described as the first English Marxist, Morris ‘became’ a socialist when he joined the Democratic Federation in 1883. Morris was also deeply concerned about the destruction of the natural world caused by the increasing number of factories and he detested the stark contrast between the poverty of the factory workers and the wealth of the factory owners. He viewed the two, that is, social equality and care of the environment, as inextricably linked. Arguably, his political ideology would be best described today as eco-socialism. This thesis will demonstrate that, even as a young man, before he became politically active Morris was already thinking deeply about contemporary social and environmental problems, most of which were caused by what he viewed as the scourges of his era, capitalism and its concomitant industrialisation. This will be achieved by an examination of the cultural, social and literary influences on Morris from his childhood up to 1876. This analysis will focus on some of his literary inspirations that have not been explored to date. The aim of this thesis will be achieved , in addition, by a critical reading of Morris’s early poetry and prose from his contributions to the OCM in 1856 to the publication of Sigurd the Volsung in 1876.
19
Dias, Rui Filipe Viana. "Avaliação eletromiográfica da ativação muscular dos músculos reto abdominal e eretores da coluna em diferentes exercícios de fortalecimento do core." Bachelor's thesis, [s.n.], 2017. http://hdl.handle.net/10284/6230.
Full textAbstract:
Projeto de Graduação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciado em Fisioterapia<br>Objetivo: O presente estudo tem como objetivo avaliar a atividade muscular dos músculos reto abdominal e eretores da coluna durante o exercício de prancha com diferentes variações de estabilidade. Metodologia: A atividade eletromiográfica dos músculos de 15 participantes, 11 do sexo masculino e 4 do feminino (Mediana de idades: 22.00 (±2.00 anos); IMC: 23.41 (±3.83kg/m2)) foi analisada durante seis posições de prancha. Resultados: Foram verificadas diferenças estatisticamente significativas tanto na atividade muscular dos diferentes músculos em cada exercício, assim como diferentes atividades musculares entre cada exercício. Tendo em conta a ativação muscular de cada músculo, é possível observar que o músculo que foi mais ativado, foi o Reto Abdominal (94.01%CMV), não havendo diferenças significativas entre lado direito e lado esquerdo. Conclusão: A atividade electromiográfica dos músculos estudados foi dependente do tipo de variação do exercício de prancha, havendo maior ativação quanto mais instável fosse a superfície de apoio.<br>Objective: This study aims to evaluate the muscle activity of the rectus abdominis and spinal erector muscles during the exercise of plank, with different variations of stability. Methods: The muscle electromyographic activity of 15 participants, 11 males and 4 females (mean age: 22.00 (± 2.00 years); BMI: 23.41 (± 3.83 kg / m2)) was analyzed during six plank positions. Results: It is possible to observe that the muscle that was most activated was the Rectus Abdominis (94.01% CMV), and there were no significant differences between the right side and the left side. Conclusion: The electromyographic activity of the muscles studied was dependent on the type of variation of plank requested.<br>N/A
20
Manzoni, Rosa Maria. "Dissertação escolar : um gênero em discussão /." Assis : [s.n.], 2007. http://hdl.handle.net/11449/102475.
Full textAbstract:
Orientador: Rony Farto Pereira<br>Banca: Edina Regina Pugas Panichi<br>Banca: Maria Jose de Toledo Gomes<br>Banca: Jeane Mari Sant'Ana Spera<br>Banca: Odilon Helou Fleury Curado<br>Resumo: Esta pesquisa tem por objetivo investigar a textualização das produções dissertativas escritas na escola, de concluintes do Ensino Médio e ingressantes no Ensino Superior. Pretende, portanto, estudar suas dimensões textuais e discursivas, detectando recorrências a partir das características típicas desse discurso para, então, indexarmo-las em um gênero textual. Em outros termos, esta pesquisa pretende caracterizar a dissertação escolar como uma das práticas efetivas de linguagem na escola e, por conseguinte, legitimá-la como um gênero discursivo. O tratamento das práticas de produção do texto dissertativo a partir da perspectiva do gênero elimina a artificialidade, até então peculiar a essa prática, e leva o aluno ao seu domínio, já que o gênero é objeto concreto de ensinoaprendizagem por estar diretamente relacionado com uma situação de comunicação autêntica. Como esta pesquisa qualifica o texto dissertativo escolar como a materialização de um gênero específico da esfera de comunicação escolar, pretende, ainda, servir como um ponto de partida e instrumento para proporcionar aos professores de língua portuguesa a elaboração de propostas metodológicas para o ensino da dissertação escolar como um gênero. Dessa forma, tais propostas visam a propiciar efetivamente a flutuação do gênero dissertativo escolar que existe na escola, hoje, para aquele gênero dissertativo escolar aceito e reconhecido socialmente, conforme as habilidades e competências previstas para o ensino Médio, as quais são definidas pelos teóricos e disseminadas nos documentos oficiais da Instituição Escola.<br>Abstract: This research has as objective to investigate the textualization of written argumentative essays of students who have finished Secondary School Education and have just started Higher Education. Thus, it intends to study such written compositions in their textual and discursive dimensions, observing recurrences of some typical characteristics of this discourse so that it can be possible to index them in a textual genre. In other words, this research intends to characterize the argumentative school essay as one of the effective language practices at school and, accordingly, define them as a discourse genre. The treatment of the text production practices from the genre perspective eliminates the artificiality, peculiar to this practice, and leads the student to its mastery, since the genre is a concrete object of the teaching and learning process and is directly related to an authentic communicative situation. As this study qualifies the school argumentative essay as the materialization of a specific genre of the school communication sphere, it still intends to work as a starting-point and an instrument to provide to teachers of Portuguese the creation of methodological proposals to the teaching of the school essay as a genre. So, such proposals aim to provide effectively the fluctuation from a non-standard school genre that exists at school nowadays to a standard school genre that is socially accepted and recognized according to the abilities and competences established to the Secondary School Education, defined by the theoreticians and spread by the official documents to the School Institution.<br>Doutor
21
Neubeck, Soeren. "Scanning probe investigations on graphene." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/scanning-probe-investigations-on-graphene(e0838733-8f13-4221-ad55-124e3757ba15).html.
Full textAbstract:
In this thesis, scanning probe microscopy experiments on graphene and chemically modified graphene crystals are discussed. Since its discovery in 2004, graphene has not only impressed researchers and industry because it is a crystal that is only one atom thick, butalso because of its electronic transport properties. However, a major challenge remaining is the task to introduce an energy gap in graphene. One way to open an energy gap in pristine graphene is its confinement to nanometre sizes. To this end, methods were developed to fabricate such nanostructures out of graphene. Here, the atomic force microscope (AFM) based technique of local anodic oxidation was applied to selectively oxidise graphene. Using this technique, graphene nanostructures as small as 20~nm have been fabricated. A graphene quantum dot (QD) created with this technique was measured at low temperatures. It showed quantum Coulomb blockade behaviour, with an energy gap of 10 meV. Furthermore, the transport behaviour of these nanostructures was also investigated under ambient conditions.Scanning gate microscopy measurements carried out on a graphene quantum point contact (QPC) demonstrated the possibility to locally influence the charge carrier concentration in the QPC, and thus alter the resistance of the device. These experiments additionally prove the usefulness of local anodic oxidation to create graphene nanostructures. Equally tempting as opening a gap in graphene and studying the resulting transport properties is the prospect of studying the influence of the edges terminating a graphene crystal on its transport properties. To that end, reliable methods for obtaining the crystallographic orientation of a given edge are needed. While most techniques require either elaborated sample fabrication or modelling, it is shown here how atomically resolved scanning tunnelling microscopy (STM) imaging together with Raman spectroscopy can be used to determine the crystallographic direction of graphene edges without doubt. An alternative way of creating an energy gap in graphene is its modification with atomic hydrogen. Atomic force microscopy was first used to measure the topography of hydrogenated graphene crystals. It is further shown, how the amount of adsorbed hydrogen could be decreased using AFM. The changes induced in the hydrogenated graphene samples in this way have been further corroborated by Raman spectroscopy and low temperature transport experiments, establishing AFM as a method to engineer the resistance of hydrogenated graphene.
22
Des, Rochers Arianne. "Les stratégies de résistance féministe, lost in translation : comment la prose d'Ena Lucía Portela met les éthiques de la traduction à l'épreuve." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31877.
Full textAbstract:
La traduction peut-elle véritablement créer un dialogue transculturel éthique et non hiérarchique? C'est la question que souhaite déconstruire cette thèse, plutôt que d'y répondre. Celle-ci s'articule ainsi autour de la notion d'éthique de la traduction : en explorant d'abord certains des récents développements en théorie féministe et en traductologie, nous souhaitons découvrir les fondements de différentes éthiques du traduire afin de les mettre à l'épreuve. Puis, en analysant le style de l'auteure cubaine dissidente et transgressive Ena Lucía Portela en traductions française et anglaise, nous découvrons que la traduction fait subir de nombreux changements au discours transgressif de l'auteure, inscrivant celui-ci dans les normes des cultures d'arrivée. Nous en concluons que la pratique de la traduction doit revoir ses objectifs et ses stratégies et prendre en considération les arguments des théories féministes actuelles si elle veut pouvoir prétendre participer à un dialogue éthique et avoir une « visée résistante ». La présente thèse propose ainsi une réflexion féministe transnationale sur l'éthique et sur la pratique de la traduction littéraire à l'heure actuelle.
23
Gramlich, Gabriela. "From 2,3-Diazabicyclo[2.2.2]oct-2-ene to Fluorazophore-L, a membrane-bound fluorescent probe for antioxidants /." Basel : [s.n.], 2004. http://edoc.unibas.ch/diss/DissB_6932.
Full text
24
Rao, Arun J. "Analog Front-End Design Using the gm/ID Method for a Pulse-Based Plasma Impedance Probe System." DigitalCommons@USU, 2010. https://digitalcommons.usu.edu/etd/675.
Full textAbstract:
The Plasma Impedance Probe (PIP) is an electronic instrument that measures the impedance of a dipole antenna immersed in a plasma environment. Measurements made by the PIP provide valuable information regarding the plasma environment. Knowledge of ionospheric plasma density and density disturbances is required to understand radio frequency communication with satellites. The impedance curve provides us with significant plasma characteristics such as the electron-neutral collision frequency and plasma electron density.
The work proposed here is a transistor-level implementation of the analog front-end, the non-inverting amplifier that is used to drive the antenna. The antenna immersed in plasma is excited with a sinusoidal/pulse stimulus and the output from the non-inverting configuration is fed into the difference amplifier. In the difference amplifier the output signal from the non- inverting amplifier is subtracted from the original stimulus and then fed into a high-speed pipeline data converter. The entire analog and mixed signal components are integrated on a single chip. The obvious advantages with this design are that it eliminates several sources of analog signal processing errors, thereby improving stability. A Fast Fourier Transform (FFT) is then applied on the sampled input stimulus as well as the processed signal. The input voltage FFT is then divided by the current FFT to obtain the antenna impedance. The FFT method helps in reducing transient errors and improves noise immunity of the system. The antenna impedance span curves over the frequency range from 100 kHz to 20MHz.
The approach for the tranistor-level design is implementing short-channel design tech- niques using the gm/ID method. This is the primary focus of the thesis where the emphasis has been on using a simple and intuitive method to design the front-end amplifier in the TSMC .35 um technology. The design specifications for this amplifier are derived from the system-level simulations. The transition from a Printed Circuit Board (PCB)-based design to System on Chip (SOC) implementation is explored. This makes the design components highly specific to the application.
The following are the design approaches used for the analog front-end design.
* A detailed study of the various factors affecting the PIP instrument measurement capabilities from the previous works.
* System-level simulation of the the entire PIP system to completely characterize the analog front-end.
* Exploration of the possible design topologies for the transistor-level implementation.
* A novel method of analog amplifier design using the gm/ID methodology.
Miniaturization of the instrument and using a pulse-based measurement scheme also offer an immediate benefit to sounding rocket missions. The reduction of power, mass, and volume will enable the instrument to be flown on many more sounding rockets than at present. The faster measurement is especially valuable since the ionospheric plasma changes in character most rapidly with altitude.
25
Selvan, Nithya. "Reductionist animal models to probe protein O-GlcNAcylation." Thesis, University of Dundee, 2015. https://discovery.dundee.ac.uk/en/studentTheses/6034adb4-fc6a-4c47-ade6-74e0b18d4297.
Full textAbstract:
Protein O-GlcNAcylation is a reversible type of glycosylation of serine and threonine residues of nucleocytoplasmic proteins occurring in all animals examined to date. Its installation on protein substrates is carried out by O-GlcNAc transferase (OGT), and its removal by O-GlcNAc hydrolase (O-GlcNAcase or OGA). A range of proteomics studies have suggested that over a thousand intracellular proteins are O-GlcNAc modified. However, little is known of the role of O-GlcNAc on these proteins. In a search for a reductionist model with a small proteome to dissect the general global mechanisms of protein O-GlcNAcylation, I discovered the presence of functional OGT, OGA and nucleocytoplasmic protein O-GlcNAcylation in the most basal extant animal, the placozoan Trichoplax adhaerens. I show via enzymatic characterization of Trichoplax OGT/OGA and genetic rescue experiments in Drosophila melanogaster that these proteins possess activities/functions similar to their bilaterian counterparts. While Trichoplax is not currently amenable to genetic manipulation, studying protein O-GlcNAcylation in this organism has revealed the presence of OGT, OGA and O-GlcNAc in non-bilaterian animals. Together with the absence of O-GlcNAcylation in lower organisms, this suggests that OGT-dependent reversible protein O-GlcNAcylation is a metazoan innovation, which may have facilitated the rapid and complex signaling mechanisms required for the evolution of multicellular organisms. Various genetic approaches in several animal models have revealed that protein O-GlcNAcylation is required for embryogenesis. Embryonic development in a genetically tractable organism is thus a model in which the mechanisms of protein O-GlcNAcylation can be investigated. Drosophila melanogaster OGT is a polycomb gene, null mutants of which display homeotic transformations and die at the pharate adult stage. However, the identities of the modified proteins involved, and the underlying biology linking these to embryonic development are poorly understood. One of the limiting factors towards characterizing O-GlcNAcylation has been the limited specificity of currently available tools to detect this modification. Harnessing the unusual properties of a catalytically inactive bacterial O-GlcNAcase mutant that binds O-GlcNAc sites with sub-micromolar affinity, I show that protein O-GlcNAcylation is dynamic along Drosophila embryonic development. In addition to immunoprecipitation using the anti-O-GlcNAc antibody RL2, I have used the mutant OGA probe to enrich for O-GlcNAcylated proteins from samples of embryos at various developmental stages, and using mass spectrometry, identified novel conserved O-GlcNAcylated proteins. There is evidence in the literature for some of these O-GlcNAc proteins being involved in the regulation of hox gene expression, suggesting that the lack of O-GlcNAcylation of these proteins may contribute to the homeotic phenotypes observed in ogt null Drosophila mutants. This thesis therefore lays the foundation for the investigation of the mechanisms by which protein O-GlcNAcylation of specific substrates would affect a process such as embryonic development.
26
Spencer, Ben. "Pump-probe spectroscopy of photovoltaic materials." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/pumpprobe-spectroscopy-of-photovoltaic-materials(f4b7f755-338a-4fad-814c-4dcc95d5b72d).html.
Full textAbstract:
The study of photovoltaic materials is important so as to develop new solar energy technologies: in particular, quantum-confined semiconductors could offer increased quantum efficiencies at a much lower manufacture cost. This thesis contains results from a number of pump-probe experiments designed to probe the carrier dynamics in bulk and quantum-confined photovoltaics. A THz time-domain spectrometer was designed, built and commissioned. The THz refractive indices and absorption coefficients of toluene and hexane were determined, and the spectrometer was benchmarked using a photoexcited GaAs wafer. Results are presented of time-resolved THz spectroscopy of photoexcited bulk InP as a function of laser excitation wavelength. These data were used to extract the quantum efficiency of bulk InP in order to compare with recent results for InP quantum dots. The quantum efficiency in quantum dots increases when the incident photon energy is at least twice the band gap energy, whereasthe efficiency of the bulk material is found to decrease. This is because of surface recombination, and these measurements therefore verify the potential superiority of quantum dot materials over bulk materials for use in solar energy applications. Initial measurements of quantum dots using THz spectroscopy highlighted the various experimental challenges involved and the upgrades required to study such samples in the future.The time-dependence of the photoinduced surface photovoltage (SPV) in Si was studied on nanosecond timescales by synchronizing an ultrafast laser system to a synchrotron radiation source (the SRS at Daresbury, UK), and measuring the resulting shift in the photoelectron spectrum. The equilibrium band bending was determined, and the decay of the SPV was attributed to the recombination of charge carriers across the band gap. Results are presented for the SPV in bulk ZnO and for PbS quantum dot chemically attached to ZnO. The fact that the PbS quantum dots were chemically attached to the surface without becoming oxidized was verified using X-ray photoelectron spectroscopy (XPS). The changes caused by photoexcitation occur on much longer timescales in ZnO than Si (sub-milliseconds rather than nanoseconds), and these timescales were conveniently accessed using the time-resolved XPS facility at the TEMPO beamline at Synchrotron SOLEIL (Paris, France). This is due to oxygen adsorption and desorption processes at the ZnO surface affectingthe transfer of charge carriers. The addition of PbS quantum dots to the ZnO surface was found to increase the speed of this charge transfer due to injection of carriers directly from the PbS quantum dot to the bulk ZnO conduction band.
27
Locherbie-Cameron, M. A. "Ælfric's Old English 'Admonition to a Spiritual Son' : an edition." Thesis, Bangor University, 1998. https://research.bangor.ac.uk/portal/en/theses/aelfrics-old-english-admonition-to-a-spiritual-son--an-edition(ca3940c8-f5f3-4003-88d9-ea3429f5f5f4).html.
Full textAbstract:
The anonymous Old English translation of the Admonitio ad Filium Spiritualem ascribed to St. Basil has hitherto been accessible only in the 1848/9 editions ofHW. Norman and the 1974 unpublished PhD dissertation ofL.E. Mueller. This edition takes into consideration the work of both editors, but pursues the relevant issues somethat further, beginning with the ascription of the work to iElfric. I use the single authoritative Hatton Ms 76A as the basis for my text; the critical introduction includes sections on the history of this manuscript and its two transcriptions, its possible relation to known Latin manuscripts of the text, and its orthography, punctuation and accent marks, and a full list of the annotations in the tremulous hand of the Worcester scribe. In considering the transmission of the text to iElfric, I include sections on St. Basil's status as a monastic legislator to explain the text's currency, the penitential tradition and the place of the Admonitio within the iElfiic canon. I conclude with analysis of the Old English text, its linguistic focus, style and structure, arguing that the Old English text may not be as incomplete as has previously been thought. To accompany my text I provide textual notes, a full commentary, which includes identification of the sources of some concepts not found in the Latin, and a Glossary. As Appendices I include a transcription of a part of Bodley Ms 800, the closest available version of iElfric's source, a provisional handlist of manuscripts in British libraries and elsewhere containing part or all of the Latin Admonitio, and a list of the accent marks on Hatton Ms 76A, ff 55-67v, together with a chart to show their line-distribution.
28
Aio, Allan de Abreu. "O jornalismo e a literatura em Otto Lara Resende /." São José do Rio Preto : [s.n.], 2007. http://hdl.handle.net/11449/99122.
Full textAbstract:
Orientador: Gentil Luiz de Faria<br>Banca: Flávio Loureiro Chaves<br>Banca: Orlando Amorim<br>Resumo: Este estudo pretende discutir as relações entre jornalismo e literatura enquanto discursos que se cruzam ao longo da história e, ao mesmo tempo, preservam características singulares que os distanciam de uma relação mais próxima nos tempos atuais. Do lado do jornalismo, o "bom português" pregado pelos manuais de redação não é suficiente para potencializar a capacidade de informação do discurso, diante de um referencial ora complexo, ora sutil. Nesses casos, a linguagem da mediação social poderia ultrapassar o simples domínio técnico da gramática e do jargão jornalístico por meio da crônica, fusão bem acabada entre o relato do real e o construto literário. O presente trabalho busca analisar parte da produção cronística de Otto Lara Resende, por sua versatilidade no tratamento da notícia. Otto confere ao fato jornalístico uma dimensão muito mais profunda, sob um prisma muito mais rico do que pretende o relato usual da notícia, por meio de um discurso construído literariamente. Assim, desmistifica a pretensão da verdade da narrativa de jornal e, ao mesmo tempo, tira da literatura a formalidade que lhe é característica,trazendo-a ao "rés-do-chão".<br>Abstract: This study intends to analyze the relations between journalism and literature as discourses which intersect themselves along history and, at the same time, maintain singular characteristics that distance them from a closer relation at the present time. In journalism, the "good Portuguese" diffused by writing manuals is not enough to boost the capacity of information discourse, when facing references whether complex or subtle. In such cases, the language of social mediation could outpass the simple grammar and journalistic jargons technical command by means of the newspaper column, which is a good fusion of the real report and the literary construct. The paper aims at analyzing part of the newspaper column production written by Otto Lara Resende for his versatility on the news usage. Otto provides the journalistic notice with a deeper dimension by using a literary discourse, from a much richer perspective than the one intended by the usual narration. Consequently, he demystifies the pretension of the truth in the newspaper narrative and, at the same time, also removes the typical formality from literature, bringing it close to the ground.<br>Mestre
29
Santilli, Nicola. "The problem with the prose poem in English literature : towards a definition." Thesis, King's College London (University of London), 1998. https://kclpure.kcl.ac.uk/portal/en/theses/the-problem-with-the-prose-poem-in-english-literature--towards-a-definition(591aae5a-a4c6-424a-8e14-56444c8915d4).html.
Full text
30
Kovalev, Manuela. "The function of Russian obscene language in late Soviet and post-Soviet prose." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-function-of-russian-obscene-language-in-late-soviet-and-postsoviet-prose(fc0db109-e18d-4156-9b8c-53e7abad6318).html.
Full textAbstract:
This thesis is the first book-length study to explore the function of Russian obscene language (mat) in late Soviet and post-Soviet prose published between the late 1970s and the late 1990s. This period was characterised by radical socio-ideological transformations that also found expression in major shifts of established literary and linguistic norms. The latter were particularly strongly reflected in the fact that obscene language, which was banned from official Soviet discourse, gradually found its way into literary texts, thereby changing the notion of literary language and literature. The thesis breaks new ground by employing obscene language as a prism through which to demonstrate how its emergence in literature reflected and contributed to the shifts of established literary norms and boundaries. A second aim of the thesis is to trace the diachronic development of Russian literary mat. Primary sources include novels by authors pioneering the use of mat in fiction in the late 1970s, as well as texts by writers associated with ‘alternative prose’ and postmodernism. Applying a methodological framework that is based on an approach combining Bakhtinian dialogism with cultural narratology, the study demonstrates what the use of mat means and accomplishes in a given literary context. The methodological framework offers a systematic approach that does justice to the dynamic relationship between text and context, allowing for an analysis of the role of obscene language on all narrative levels while also taking the socio-historical context into account. The thesis offers not only new ways of interpreting the novels selected, it also provides new insight into the role of verbal obscenity in the process of ‘norm negotiation’ that has shaped and transformed Russian literary culture since the late 1970s. By accentuating the dialogic nature of obscene language, this study reveals that mat is a defining element of Russian (literary) culture, with implications for all facets of Russian identity.
31
Almeida, Gonçalo Emanuel Pacheco de. "Simulação numérica e avaliação experimental do desempenho de sondas inovadoras de correntes induzidas em diferentes materiais e defeitos." Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/8517.
Full textAbstract:
Dissertação para obtenção do Grau de Mestre em
Engenharia Mecânica<br>Nos últimos anos, desenvolvimentos nos END por Correntes Induzidas conduziram a uma sonda inovadora designada IOnic Probe. Esta sonda tem demonstrado bom desempenho na detecção de micro-defeitos superficiais, nomeadamente na Soldadura por Fricção Linear (SFL). Recentemente, alguns parâmetros geométricos foram optimizados, tendo em vista aumentar a eficácia na detecção de defeitos. Desta optimização resultaram novas configurações geométricas da sonda. No entanto, a sua aplicação tem estado restrita a defeitos padrão em alumínio e à SFL.
O objectivo deste trabalho foi estender a aplicação da sonda a outros materiais e a outras morfologias de defeito, tendo em vista avaliar o seu desempenho comparativamente às sondas convencionais.
Foram produzidos defeitos artificiais paralelos à superfície, matrizes de furos e juntas bimetálicas em vários materiais de engenharia, nomeadamente nos aços AISI 1012 e AISI 304, alumínio AA1100, AA5083-H12 e AA6061-T6, ferro fundido GG25, cobre electrolítico, grafite e em GLARE®. Foram desenvolvidos e produzidos dispositivos de movimentação automatizada de sondas. Foram realizados ensaios experimentais com diferentes sondas IOnic e convencionais, e os resultados foram comparados com os resultados de simulações numéricas.
Os ensaios mostram que a sonda IOnic apresenta uma boa sensibilidade comparativamente às sondas convencionais na detecção de quase todos os defeitos e material. Concluiu-se também que a sua capacidade de detecção de defeitos em profundidade é em muitos casos superior à das sondas convencionais, nas mesmas condições de inspecção.
32
Buchanan, Greg Roy. "Identification and character : negotiating between inferred authority and reader causality in prose novels and video games." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/identification-and-character(fab38757-f73c-4d6e-958e-63a1a6aa9e26).html.
Full textAbstract:
In this thesis I undertake a comparison of novels and video games in order to clarify the ontological and ethical processes involved in reader construction of fictional characters. I demonstrate how the sequences of novels necessitate inference of textual authority. In contrast, although video games offer control over sequence, such control is unstable and can be compared with the effects of reader emotional engagement where inference as to what might happen in a narrative will often transform into what should happen next on behalf of various characters. Furthermore, I argue that as all characters must be constructed and staged on an ongoing basis for any feeling of allegiance to be sustained, identification should be seen as representing the ongoing construction and evaluation of all fictional characters in a given text. As a result of these arguments, I propose the concept of reader/player causality, by which I refer to the general philosophical orientation underpinning what the player brings to the text in this regard even beyond what textual revelations can erase. In video games, for example, players seem synonymous with their avatars, but frequently game narratives will provide explanations for player actions that are inconsistent with the real life player’s intention, with the player’s initial bias still affecting the character produced. Reader causality operates in a similar way where the reader’s wish for certain events to occur will likewise affect interpretation and identification even if subsequent narrative events contradict prior assumptions or wishes. In turn, the reader’s acceptance of such additions or alterations to characters carries with it ethical responsibility and choice. In this manner, I define identification as the imposition of reader causality/feeling combined with the absorption of diegetic rewriting of all characters in a text on a moment-by-moment basis with new versions negotiated in contract with inferred authority.
33
Wantzen, Prany. "La mémoire chez l’adolescent avec autisme : électrophysiologie, cognition et prise en charge." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLEP071.
Full textAbstract:
Les troubles du spectre autistique (TSA) correspondent à des troubles neuro-développementaux caractérisés par des altérations de la communication sociale ainsi qu’à des comportements restreints et répétitifs. Les TSA sont associés à des anomalies cérébrales anatomiques, fonctionnelles et de connectivité qui participent au fonctionnent cognitif atypique de cette population. Ce travail comprend trois projets visant à caractériser le profil neurocognitif d’adolescents et de jeunes adultes avec TSA et de proposer de nouvelles prises en charge. Le premier met en évidence des anomalies de connectivité cérébrale au repos en électroencéphalographie, pouvant rendre compte des difficultés d’intégration multimodale ayant des répercussions sur les processus d’introspection. Le second projet approfondit l’étude de ces processus d’introspection dans le cadre de la mémoire autobiographique (MAB). Nous mettons en évidence des difficultés de MAB chez les adolescents avec TSA en comparaison avec des sujets typiques, avec un profil sensoriel particulier, mais aussi l’existence d’un bénéfice significatif d’une relance et d’indices visuels lors de la récupération. Au-delà, nos travaux soulignent l’intérêt d’une réhabilitation de la MAB, utilisée comme un vecteur primaire dans les interactions sociales. Le troisième projet porte sur un la création d’un programme de réhabilitation de la MAB fondé sur une approche individuelle et collective, et dont les résultats préliminaires montrent un effet bénéfique sur l’identité sociale des adolescents avec autisme. La MAB constitue un objet d’étude particulièrement pertinent dans l’autisme, puisqu’il intégre une dimension multimodale, et favorise une réhabilitation dans un cadre écologique<br>Autism spectrum disorders (ASD) are neurodevelopmental disorders, characterized by difficulties in social communication with restricted and repetitive behaviors. ASD are associated with structural, functional and connectivity brain abnormalities that contribute to atypical cognitive functioning in this population. This work includes three projects aimed at characterizing the neurocognitive profile of ASD adolescents and young adults and proposing new rehabilitation programs. The first shows abnormal resting-state brain connectivity using electroencephalography that can account for the multimodal integration difficulties that directly impact introspection processes. The second project deepens the study of introspection processes in the context of autobiographical memory (ABM). The data collected confirm the ABM difficulties in ASD adolescents, with an atypical sensory profile, but also the existence of a positive effect of prompting and visual cues during recall. Beyond, our work highlights the importance of ABM rehabilitation, used as a key vector in social interactions. Then, the third project concerns the creation of an ABM rehabilitation program based on an individual and collective approach. Preliminary results show a beneficial effect on the social identity of adolescents with autism. ABM is, therefore, very relevant to study in autism, integrating a unique and ecological multimodal dimension, and an interesting tool of rehabilitation
34
Acunzo, David Jean Pascal. "Interaction between visual attention and the processing of visual emotional stimuli in humans : eye-tracking, behavioural and event-related potential experiments." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8016.
Full textAbstract:
Past research has shown that the processing of emotional visual stimuli and visual attention are tightly linked together. In particular, emotional stimuli processing can modulate attention, and, reciprocally, the processing of emotional stimuli can be facilitated or inhibited by attentional processes. However, our understanding of these interactions is still limited, with much work remaining to be done to understand the characteristics of this reciprocal interaction and the different mechanisms that are at play. This thesis presents a series of experiments which use eye-tracking, behavioural and event-related potential (ERP) methods in order to better understand these interactions from a cognitive and neuroscientific point of view. First, the influence of emotional stimuli on eye movements, reflecting overt attention, was investigated. While it is known that the emotional gist of images attracts the eye (Calvo and Lang, 2004), little is known about the influence of emotional content on eye movements in more complex visual environments. Using eye-tracking methods, and by adapting a paradigm originally used to study the influence of semantic inconsistencies in scenes (Loftus and Mackworth, 1978), we found that participants spend more time fixating emotional than neutral targets embedded in visual scenes, but do not fixate them earlier. Emotional targets in scenes were therefore found to hold, but not to attract, the eye. This suggests that due to the complexity of the scenes and the limited processing resources available, the emotional information projected extra-foveally is not processed in such a way that it drives eye movements. Next, in order to better characterise the exogenous deployment of covert attention toward emotional stimuli, a sample of sub-clinically anxious individuals was studied. Anxiety is characterised by a reflexive attentional bias toward threatening stimuli. A dot-probe task (MacLeod et al., 1986) was designed to replicate and extend past findings of this attentional bias. In particular, the experiment was designed to test whether the bias was caused by faster reaction times to fear-congruent probes or slower reaction times to neutral-congruent probes. No attentional bias could be measured. A further analysis of the literature suggests that subliminal cue stimulus presentation, as used in our case, may not generate reliable attentional biases, unlike longer cue presentations. This would suggest that while emotional stimuli can be processed without awareness, further processing may be necessary to trigger reflexive attentional shifts in anxiety. Then the time-course of emotional stimulus processes and its modulation by attention was investigated. Modulations of the very early visual ERP C1 component by emotional stimuli (e.g. Pourtois et al., 2004; Stolarova et al., 2006), but also by visual attention (Kelly et al., 2008), were reported in the literature. A series of three experiments were performed, investigating the interactions between endogenous covert spatial attention and object-based attention with emotional stimuli processing in the C1 time window (50–100 ms). It was found that emotional stimuli modulated the C1 only when they were spatially attended and task-irrelevant. This suggests that whilst spatial attention gates emotional facial processing from the earliest stages, only incidental processing triggers a specific response before 100 ms. Additionally, the results suggest a very early modulation by feature-based attention which is independent from spatial attention. Finally, simulated and actual electroencephalographic data were used to show that modulations of early ERP and event-related field (ERF) components are highly dependent on the high-pass filter used in the pre-processing stage. A survey of the literature found that a large part of ERP/ERF reports (about 40%) use high-pass filters that may bias the results. More particularly, a large proportion of papers reporting very early modulations also use such filters. Consequently, a large part of the literature may need to be re-assessed. The work described in this thesis contributes to a better understanding of the links between emotional stimulus processing and attention at different levels. Using various experimental paradigms, this work confirms that emotional stimuli processing is not ‘automated’, but highly dependent on the focus of attention, even at the earlier stages of visual processing. Furthermore, the uncovered potential bias generated by filtering will help to improve the reliability and precision of research in the ERP/ERF field, and more particularly in studies looking at early effects.
35
Catterson, Jade. "The relational lives of street-connected young people in hazard prone areas of Jamaica." Thesis, University of Dundee, 2017. https://discovery.dundee.ac.uk/en/studentTheses/d19139ec-b8d5-47b3-9edd-ade33eb770dc.
Full textAbstract:
This thesis is an exploration into the lives of street-connected young people living in disaster prone communities in the Caribbean country of Jamaica. Street-connected young people’s lives have been well documented over the past few decades in relation to their immediate spaces, activities and more recently, relationships. Street-connected young people have been found to be part of wider social structures in society which have bearing on how they prepare for, react to, negotiate and overcome challenges that they are faced with, both at the local level and on a much larger scale, including adverse events like ‘natural’ disasters. While this study appreciates the progression of the literature on this once overlooked social group, it suggests that there is still a gap in the literature in respect to how street-connected young people’s relationality is understood and explored. Jamaican street-connected young people’s relationality is complex and formed of context-specific networks and relationships. These not only include close knit relationships with family and friends but also wider community relationships with neighbours and extended family and relationships with people out with the community in other parts of Jamaica and abroad. The wider political, social and economic structures in place nationally which street-connected young people are embroiled are additionally considered, particularly in how it influences the coping mechanisms of street-connected young people. This thesis draws on street-connected young people’s relationality to examine how it shapes their resilience and to what extent their positon within this wider web of relationships in Jamaica is crucial to how they prepare and manage the hurricanes and flooding taking place there. Extant studies on young people’s resilience have begun to appreciate the role of the social context and relational networks in enhancing or reducing their resilience, looking beyond traditional studies focusing on an individual’s traits or personal attribute. In this research I have expanded upon the concept of relational resilience to look at how it manifests itself in the lives of street-connected young people, an area currently understudied. A participatory ethnography approach has been adopted in the methodology, using a range of participatory methods to develop a comprehensive and holistic understanding of life for street-connected young people, with the view to establishing their situation in disaster events, how they demonstrate resilience when faced with adversity and how best to tailor national disaster risk management and reduction strategies to suit them and their communities’ needs. By using methods which encourage participation among everyone, a space of collaboration and knowledge exchange can be generated to gain the most informed responses and outcomes.
36
Pao, Kuan-Chuan. "Design and synthesis of an E3 ligase activity-based probe and its application for the discovery of a new class of E3 ligase." Thesis, University of Dundee, 2018. https://discovery.dundee.ac.uk/en/studentTheses/6239e172-60b3-47c3-81e1-f4b0a577f1a4.
Full textAbstract:
The ubiquitylation cascade regulates multiple cellular functions and is involved in numerous diseases. The distinct transfer cascade, involving E1-E2-E3 enzymes, serves as a promising target for drug development. However, E3 ligases (E3s) represent an important class of enzymes yet there are currently no effective tools for profiling their activity. Herein, a new class of E3 activity-based probe (ABP) is presented which is built by re-engineering ubiquitin (Ub)-charged E2 conjugating enzymes. The utility of these probes has been demonstrated by the rapid dissection of the activation determinants of the RING-Between-RING E3 (RBR) E3, Parkin. Furthermore, biotin-E3 ABPs allow us to systematically discover and dissect the E3 activities of a broad spectrum of E3s that are associated with different diseases. By interfacing the ABPs with mass spectrometry, we establish an activity based protein profiling (ABPP) system and apply it to uncover a new class of E3. We show that MYCBP2 is an E3 ligase with a novel mechanism of action that ubiquitylates threonine residues. MYCBP2 contains a RING domain, that recruits the ubiquitin-loaded E2, and a novel Zn-binding fold that contains two catalytic cysteine residues which relay the Ub to substrate via two thioester intermediates (RING-Cys-Relay, RCR). This discovery demonstrates the power and potential of our E3 activity based protein profiling (ABPP) system.
37
Marchi, Maria Nazar? Guimar?es. "Aspectos fisiol?gicos, anat?micos e moleculares da propaga??o e conserva??o in vitro de esp?cies de cactos end?micos da Bahia." Universidade Estadual de Feira de Santana, 2016. http://localhost:8080/tede/handle/tede/360.
Full textAbstract:
Submitted by Ricardo Cedraz Duque Moliterno (ricardo.moliterno@uefs.br) on 2016-07-20T00:37:17Z
No. of bitstreams: 1
Tese_final_ MARCHI.MNG.pdf: 2477043 bytes, checksum: 875c56fb9a49e8316ee438fe52b80636 (MD5)<br>Made available in DSpace on 2016-07-20T00:37:17Z (GMT). No. of bitstreams: 1
Tese_final_ MARCHI.MNG.pdf: 2477043 bytes, checksum: 875c56fb9a49e8316ee438fe52b80636 (MD5)
Previous issue date: 2016-05-04<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES<br>The family Cactaceae has approximately 100 genera and 1500 species predominantly American and distributed by a wide variety of climates and ecosystems. Due to the high singularity in terms of genres and endemic species as well as the potential use of these plants for various purposes, studies on the in vitro propagation and ex situ conservation of these species must be established. Thus, the aim of this study was to understand the anatomical, physiological and molecular changes associated with the propagation and conservation in vitro Discocactus zehntneri subsp boomianus and Stephanocereus leutezlburgii, species endemic cactus of Bahia with ornamental potential. The regulators applied not exceeded the control in the induction of shoots/explant in both species and for S. luetzelburgii combination of cytokinins and auxins hiperidricos increased the percentage of shoots that did not survive after acclimatization. Normal shoots of this species have 100% survival in ex vitro conditions. The callus formation was enhanced by adding auxin to the nutrient medium for the two species analyzed and calluses with potential for in vitro morphogenesis were obtained. The proteomic analysis revealed the marker proteins differential expression of somatic embryogenesis in two strains of S. luetetzelburgii calluses. The protocol for cryopreservation D. zehntneri shoots was not effective, however the seed storage either in liquid nitrogen conditions as for ultrafreezer maintained physiological quality after storage for 360 and 180 days, respectively. Osmotic agents were effective in inhibiting in vitro growth of the species for a year without loss of viability.<br>A fam?lia Cactaceae apresenta cerca de 100 g?neros e 1500 esp?cies predominantemente americanas e distribu?das por uma ampla diversidade de climas e ecossistemas. Devido ? alta singularidade em termos de g?neros e esp?cies end?micas bem como o uso potencial destas plantas para diversas finalidades, estudos acerca da propaga??o in vitro e conserva??o ex situ dessas esp?cies devem ser estabelecidos. Desta forma, o objetivo geral deste trabalho foi compreender as mudan?as anat?micas, fisiol?gicas e moleculares associadas ? propaga??o e conserva??o in vitro de Discocactus zehntneri subsp boomianus e Stephanocereus leutezlburgii, esp?cies de cact?ceas end?micas da Bahia com potencial ornamental. Os reguladores aplicados n?o superaram o controle na indu??o de brotos/explante em ambas as esp?cies e para S. luetzelburgii a combina??o de citocininas e auxinas aumentaram o percentual de brotos hiperidricos que n?o sobreviveram ap?s a aclimatiza??o. Brotos normais dessa esp?cie apresentaram 100% de sobreviv?ncia em condi??es ex vitro. A calog?nese foi potencializada pela adi??o de auxinas ao meio nutritivo para as duas esp?cies analisadas e calos com potencial para morfog?nese in vitro foram obtidos. A an?lise prote?mica revelou a express?o diferencial de prote?nas marcadoras da embriog?nese som?tica em duas linhagens de calos de S. luetetzelburgii. O protocolo para criopreserva??o de brotos de D. zehntneri n?o foi eficiente, no entanto a armazenamento de sementes tanto em condi??es de nitrog?nio l?quido quanto em ultrafreezer mantiveram a qualidade fisiol?gica ap?s o armazenamento por 360 e 180 dias, respectivamente. Os agentes osm?ticos foram eficientes em inibir o crescimento in vitro da esp?cie por um ano sem perda na viabilidade.
38
Labadie, Philippe. "Intérêt du monitorage de l'EtCO2 dans la prise en charge ventilatoire des patients transportés en SMUR." Bordeaux 2, 1995. http://www.theses.fr/1995BOR2M146.
Full text
39
Kah, Damien. "Prise en compte des aspects polydispensés pour la modélisation d'un jet de carburant dans les moteurs à combustion interne." Phd thesis, Ecole Centrale Paris, 2010. http://tel.archives-ouvertes.fr/tel-00628908/en/.
Full textAbstract:
Le contexte général de cette thèse est la simulation numérique de l'injection de carburant dans un moteur à combustion interne, afin d'améliorer son rendement et de limiter la production de polluants. De manière plus générale, ce travail s'applique à tout système industriel mettant en jeu un écoulement multiphasique constitué d'un carburant liquide injecté dans une chambre occupée initialement par du gaz, comme par exemple les moteurs automobiles ou aéronautiques, ou les turbomachines. Intrinsèquement, il est possible de simuler l'ensemble de l'écoulement avec les équations classiques de la dynamique des fluides sans avoir recours à des outils de modélisation supplémentaires liés au caractère diphasique. Mais, les tailles des structures générées pendant l'injection (gouttes de diamètre inférieur à 10 μm) conduisent à des temps de calculs prohibitifs pour une application industrielle. C'est pourquoi il est nécessaire d'introduire une modélisation diphasique. C'est dans ce contexte que deux régions sont formellement distinguées: le coeur liquide dense proche de l'injecteur, appelé écoulement à phases séparées, et le spray constitué d'une population de gouttes polydisperse (c'est-à-dire de tailles différentes) générées après le processus d'atomisation en aval de l'injecteur. Ce travail de thèse étudie les modèles Eulériens pour la description de spray évaporants et polydisperses, en vue d'applications industrielles. Ils représentent une alternative potentielle aux modèles Lagrangiens qui sont majoritairement utilisés en industrie mais présentant des inconvénients majeurs. Ainsi, le modèle multi-fluide est étudié dans un premier temps. Bien que prometteur, deux difficultés sont soulignées: le coût requis pour une description précise de la polydispersion, et son incapacité à décrire les croisements de gouttes (particle trajectory crossing, PTC, en anglais). La thèse propose des solutions à ces deux limitations. Ces solutions reposent chacune sur des méthodes de moments. Premièrement, le modèle appelé Eulerian Size Multi Size Moment (EMSM) permet de résoudre des sprays évaporants et polydisperses de manière bien plus efficace que le modèle multi-fluide. Des outils mathématiques sont utilisés pour fermer le système d'équations associé au modèle, et combinés à des schémas de types volumes finis appelés schémas cinétiques, afin de préserver la réalisabilité du vecteur de moments, pour le transport et l'évaporation. Une réponse à la seconde limitation est apportée avec le modèle appelé Eulerian Multi Velocity Moment (EMVM) basé sur le transport de moments en vitesse d'ordre élevé. Une distribution bimodale peut être localement reconstruite à partir des moments en utilisant une méthode de quadrature de moments (Quadrature Method of Moment, QMOM en anglais) en une ou plusieurs dimensions d'espace. De la même manière que précédemment, l'utilisation de schémas cinétiques permet de préserver la réalisabilité du vecteur de moment. De plus, une étude mathématique approfondie de la dynamique du système en une dimension d'espace en révèle toute la complexité et représente une étape indispensable en vue de l'élaboration de schémas de transport d'ordre élevé (supérieur ou égal à 2).Afin de les tester, ces deux modèles ainsi que les outils numériques associés sont implémentés dans MUSES3D, un code académique de simulation numérique directe (Direct Numerical Simulation DNS en anglais) dédié à l'évaluation des modèles de spray. Des résultats de grande qualité démontrent le potentiel des modèles. L'extension du modèle EMSM dans un contexte industriel est ensuite considérée, avec son implémentation dans IFP-C3D, un code résolvant des écoulements réactifs sur des maillages non structurés et mobiles (dû au mouvement du piston) dans un formalisme RANS (Reynolds Averaged Navier Stokes) en présence de sprays. Le formalisme ALE (Arbitrary Lagrangian Eulerian en anglais) est utilisé et le modèle EMSM réécrit dans ce formalisme afin de mener des calculs en maillage mobile. De plus, une étude numérique a permis d'étendre les propriétés de précision et de stabilité obtenues en maillage fixe. La robustesse du modèle EMSM est alors démontrée avec succès dans IFP-C3D sur un cas impliquant un mouvement de piston, ainsi que dans le cadre d'une comparaison avec le code MUSES3D. Enfin, des résultats très encourageants prouvent la faisabilité d'un calcul d'injection dans une chambre de combustion d'un spray polydisperse avec le modèle EMSM.
40
Thompson, Cherrie Delos Santos. "Using the potent Pasteurella multocida toxin to probe G-protein signalling." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/using-the-potent-pasteurella-multocida-toxin-to-probe-gprotein-signalling(b9692597-dd37-4fbc-ba0d-00691809538e).html.
Full textAbstract:
The heterotrimeric G-proteins are critically important intracellular signalling molecules that regulate fundamental processes in cellular homeostasis. A unique bacterial toxin, Pasteurella multocida toxin (PMT) modifies 3 of the 4 families of G-proteins (Gq, Gi, and G12) by deamidation which leads to a plethora of downstream signalling. PMT induces drastic morphological changes such as loss of adherence to the matrix, foci and stress fibre formation in Swiss 3T3 and Vero cells. PMT is mitogenic for many cell types but not all, and the work reported in this thesis aims to compare two cell lines that respond differently to PMT. Swiss 3T3 and Vero cells were treated with different concentrations of PMT to determine the effects on cell proliferation, cytoskeletal reorganisation and cell death. PMT induced prominent cytoskeletal changes, mitogenic and anti-cell death responses in Swiss 3T3 cells while delayed cytoskeletal changes with no evidence of mitogenicity and cell death were observed in Vero cells. PMT modified G-proteins at different times in Swiss 3T3 and Vero cells. The PMT-induced anti-cell death response in Swiss 3T3 cells was dose-dependent while the delayed cytoskeletal response in Vero cells was linked to the late PMT-mediated G12 activation. The amino acid sequence of Gα12 differed in the two cell types – the G12 subunit in Vero cells is missing N-terminal cysteine residue, which may have contributed to the differences. Gq/11 signalling is active and sustained in Swiss 3T3 cells, but not in Vero cells. Gβγ may have inhibited adenylyl cyclase activity so it is unknown whether Gi signalling is active and sustained over the 3-day period as the forskolin-stimulated cAMP level decreased in both serum-starved untreated and PMT-treated cell lines. In summary, I have identified changes in both the primary effect of PMT on the two cell types and also on downstream signalling that is likely to reflect the differential cell response.
41
Lister, Francis George Alexander. "Fluorescent probes of conformational signal relay in membrane environments." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/fluorescent-probes-of-conformational-signal-relay-in-membrane-environments(baa2cddd-94a1-4505-bf45-13403e0a6548).html.
Full textAbstract:
G-Protein Coupled Receptors (GPCRs) are a class of membrane-bound receptor proteins capable of relaying a biological signal across a cell membrane through a solely conformational change in their transmembrane domain. Previous work has shown that helical foldamers composed of achiral monomeric units can be used in an analogous manner to relay stereochemical information on the nano-scale through the conformational control of screw-sense preference. While this work has produced some highly successful examples of signal relay, mimicking the function of GPCRs, its reliance on screw-sense responsive NMR probes has restricted further development into membrane environments. This thesis describes the successful development of a pyrene based screw-sense responsive fluorescence probe and its subsequent use in the development of a series of membrane-based GPCR mimics. This thesis has also details the preliminary steps towards the development of light-responsive controllers of screw-sense preference for nano-scale signal relay devices.
42
Ruiz, Ortega Leonardo Ibor. "Micropatterns for surface potential mapping of biomolecules by Kelvin probe force microscopy." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/micropatterns-for-surface-potential-mapping-of-biomolecules-by-kelvin-probe-force-microscopy(2a7d9300-f575-4786-b9a3-600e807cd66c).html.
Full textAbstract:
Current methods to detect and quantify electrostatic properties of biomolecules, nowadays, still facing many challenges. For instance, they are not sensitive enough to meet the needs of more precise measurements, they require the use of external markers or antibodies, or rely on indirect calculations or models such is the case for zeta potential and electrophoretic mobility. However, Kelvin probe force microscopy (KPFM) have gained attention due to its expanding possibilities to asses electrostatic properties of biomolecules. Among the advantages that KPFM possess over other methods, stands out its high sensitivity and spatial resolution. Moreover, it does not require the use of external labels. In the interest of establishing a method for mapping surface potential of biomolecules by means of Kelvin probe force microscopy, two techniques of poly-dimethylsiloxane (PDMS) soft lithography for micro-patterning (micro channel filling and micro contact printing) are studied. Similarly, the possibility of patterning biomolecules on different substrates (mica, glass and silicon dioxide) is explored. Primarily, poly-L-lysine was used as a model biomolecule due to the exposure of amino functional groups. Different physicochemical conditions on poly-Llysine micro patterns were tested in order to assess the suitability of soft lithography combined with KPFM to measure electrostatic properties of biomolecules. In this sense, continuous KPFM scans, immersions in water, lift height and time dependence were investigated. Moreover, due to the importance of the understanding of the effects of exposure of biomolecules to elevated levels of sugars, immersions in D-ribose were performed. A concentration dependent effect was observed, affecting drastically the surface potential of polyL-lysine. Electrostatically driven patterning of colloidal gold nanoparticles was also achieved on pol-L-lysine micro patterns, resulting in a good method for marking the presence of pol-Llysine and opening the possibility to improve some properties of nanoparticle systems. Besides microchannel filling, micro contact printing of poly-L-lysine was successfully achieved on mica, glass and silicon dioxide, resulting in better quality micro patterns and understanding of the influence of using different substrates on surface potential. On this regard, continuous KPFM scans revealed a surface charge dynamic on mica, whereas on glass and silicon dioxide surface potential became more stable. Insulin, BSA and β-lactoglobulin were successfully patterned on mica by micro contact printing and imaged by KPFM. Response to pH and immersions in water was investigated showinga clear reversible shift on surface potential. Similarly, cross-patterning of different proteins on the same substrate for surface potential oneto-one comparison was successfully achieved. The classic case of avidin-biotin complex was also investigated byboth fluorescence optical microscopy and KPFM. Finally, in an attempt to stretch the applications of KPFM for surface potential mapping of biomolecules, insulin amyloid fibrils were co-fibrillated with highly charge nanoparticles. Surface potential maps of amyloid structures were achieved and the effect of continuous scanning on surface potential was assessed.
43
Royal, Drew Sebastian. "Using ligand design to probe the redox chemistry of the actinyl ions." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/using-ligand-design-to-probe-the-redox-chemistry-of-the-actinyl-ions(f5b22cc7-2107-4d8f-8617-92ae35810777).html.
Full textAbstract:
The synthesis and characterisation of a series of {AnO₂}ⁿ⁺ complexes containing multidentate ligand environments is reported. Three novel {UO₂}²⁺ complexes (1-3) containing N₃O₂ linear pentadentate ligands have been prepared and crystallographically characterised. NMR spectroscopy has been able to show that 1-3 are stable with respect to ligand exchange, in a range of solvents. The strength of the O=U=O unit has been probed by vibrational spectroscopy and 1-3 exhibit some of the weakest O=U=O ν₁ stretching modes reported (802-805 cm⁻¹). The cyclic voltammetry (CV) of 1-3 in various solvents (0.1 M [Bu₄N][PF₆]) has been performed and indicate the position and reversibility of the {UO₂}²⁺/{UO₂}⁺ redox couple has been found to be subtly dependent on the solvation environment. {UO₂}²⁺ complexes (4-6) have been prepared by subtle modification of reaction conditions using a rigid N₂O₂S linear pentadentate ligand. Characterisation by X-Ray diffraction reveals different monometallic systems, where 4 and 5 are solely bound to the O₂ donors of the ligand and 6 exhibits uranyl binding through all of the donor atoms in the N₂O₂S cavity. ¹H NMR spectroscopy shows 5 exhibits intramolecular rearrangement on the NMR timescale in DCM, but undergoes intermolecular ligand exchange in more coordinating solvents (DMSO, py). Cyclic voltammetry of 5 in DCM (0.1 M [Bu₄N][PF₆]) also indicates that rearrangements and/or ligand exchange processes may occur at rate comparable to that of the CV studies. Complex 6 exhibits stability with respect to ligand exchange or rearrangement in various solvents and shows comparable solvation environment dependency of the {UO₂}²⁺/{UO₂}⁺ redox couple, relative to 1-3. Three monometallic {UO₂}²⁺ complexes (7-9) have been prepared using a rigid tetradentate N₂O₂ ligand. A dimetallic {UO₂}²⁺ complex (10) where two {UO₂}²⁺ are linked by a 4,4'-bipyridine bridge, has been formed by controlled ligand exchange. Vibrational spectroscopy shows the presence of the O=U=O ν₁ stretch in both the Raman and infrared spectra for 7-10, likely to be caused by distortion of the ligand about the UO₂}²⁺ equatorial plane causing a change in dipole for the O=U=O ν₁ stretching mode. A synthetic and spectroscopic study of neptunyl coordination to N₃O₂ linear pentadentate ligands has been made. Adopting a similar method that was successfully employed in the synthesis of 1-3, resulted in the reduction of {NpO₂}²⁺ to {NpO₂}⁺, giving a series of complexes (11-13). Complex 13 has been crystallographically characterised and shows a monometallic {NpO₂}⁺ complex which is bound to all of the atoms in the N₃O₂ cavity.
44
Habibi, Muhammad Khoirul Khakim. "Optimisation d'une chaîne logistique inverse avec la prise en compte des processus de désassemblage." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEM005.
Full textAbstract:
Il est connu que l'intégration des décisions dans les chaînes logistiques directes permet de proposer de meilleurs décisions. Dans cette thèse, une approche similaire est proposée pour une chaîne logistique inverse. Nous supposons que l'intégration de décisions concernant la collecte des produits en fin de vie avec celles de leur désassemblage permet d`optimiser la chaîne logistique inverse.D'abord, un problème déterministe, appelé le problème de collecte et désassemblage, intégrant les décisions de collecte de produits en fin de vie et la planification de leur désassemblage a été proposé et étudié. Etant donné qu'il n'y a pas d'instance de ce problème dans la littérature, les instances sont générées pour pouvoir effectuer les tests des modèles développés. Une comparaison de la formulation intégrée avec celle non-intégrée est effectuée. Selon les résultats obtenus, il s'avère que l'intégration permet d'optimiser les coûts totaux. Des méthodes approchées sont également proposées car le solveur CPLEX n'est pas capable de fournir les solutions optimales des instances de grand taille avec les temps de calcul acceptables. Ensuite, le problème est étendu en considérant l'incertitude sur les paramètres associés à la qualité et la quantité des produits en fin de vie et les demandes en composants. En considérant également la possibilité d'avoir plusieurs véhicules pour la collecte de produits en fin de vie, le problème stochastique de collecte et désassemblage dans sa version multi-véhicule est introduit. Sa formulation est développée sous forme d'une programmation stochastique en bi-niveau. Nous supposons qu'au moment de la planification, les paramètres incertains sont considérés comme des variables aléatoires avec des lois de distribution connues. Les réalisations de ces variables ne sont connues qu'au moment d'exécution du plan. Deux méthodes de résolution en utilisant une procédure d'approximation par échantillonnage sont implémentées afin de fournir les solutions.Finalement, un autre problème est également posé et étudié ou les décisions concernant la collecte de produits en fin de vie sont associées au problème de l'équilibrage de ligne de désassemblage<br>This dissertation supports and proposes better management in the implementation of the cir-cular economy by integrating activities of reverse supply chains. The hypothesis states thatintegrating decisions of at least two activities in reverse supply chain leads to better decisionsnotably the collection of End-of-Life products and their disassembly.A deterministic problem, called Collection-Disassembly Problem, integrating both collectionand disassembly processes as well as its formulation are introduced and developed. Due to lackof available instances in the literature, some instances are generated. Another non-integratedformulation is developed and solved using the commercial solver CPLEX. The obtained resultsshow that the integrated model proposes better decisions in terms of total cost. Some ap-proximate methods are developed because the commercial solver CPLEX is unable to provideoptimal solutions under acceptable CPU times notably for large size instances.An extended version of the problem is introduced due to the fact that reverse supply chainsfrequently deal with the uncertainty of certain parameters such as the quality and the quantityof End-of-Life products as well as the demands of components. Also, there is often more thanone vehicle available to collect the products. Thus, this second problem suggested which is calledStochastic Multi-Vehicle Collection-Disassembly Problem and its formulation is developed. Theproblem is formalised as two-stage stochastic programming by assuming that the parametersunder uncertainty follow some known probability distributions and their realisation comes afterthe planning stage. To provide the solutions, two methods combined with an algorithmicframework of Sample Average Approximation are developed.Another problem called Integrated Procurement-Disassembly Problem is also studied. Alongwith the decisions on collection process, this problem emphasises on the decisions of disassemblyline balancing problem
45
Leong, Tein Foong. "Engineering novel antibody-based molecules to probe the role of the immunoglobulin hinge and generate a potential cancer vaccine." Thesis, University of Dundee, 2017. https://discovery.dundee.ac.uk/en/studentTheses/5fe856e6-ce7a-4ff8-92c3-40c555aafd14.
Full textAbstract:
In different immunoglobulin (Ig) isotypes, the hinge region, which separates the antigen-binding Fab region from the Fc region, varies considerably in length. The hinge region is believed to provide flexibility for the Ig to conduct better positioning for antigen binding via the Fab arms or better receptor association via the Fc region. However, the reason for the difference in hinge length among different Igs is not fully understood. In this project it is hypothesised that the longer the upper hinge length of an IgG the further the distance that the antigen binding sites at the tips of Fab arms are able to reach between neighbouring antigens. In order to investigate the relation between upper hinge region of IgG and the distance between antigen binding sites, human IgG1 mutants specific for the hapten NIP which featured different upper hinge lengths were generated. Rigid bivalent ligands or “molecular rulers” (dsNIP-DNA) comprising defined lengths of double stranded DNA with NIP covalently attached to both ends were produced. ELISA tests demonstrated that anti-NIP human IgG1 bound to dsNIP-DNA. Through employment of molecular rulers of different lengths, surface plasmon resonance experiments indicated that the maximum distance between antigen binding sites is influenced by the length of the upper part of the IgG hinge. In addition, the role of upper hinge length on the ability of IgG to bridge between antigen on a target cell surface and Fc receptors on the surface of a phagocyte was investigated. Rosette formation between antibody-coated erythrocytes and Fc receptor-positive effector cells was utilised as an assay for this bridging. When anti-NIP human IgG1 hinge mutants were compared to wildtype IgG1, differences in rosette formation efficiency were observed indicating that the upper hinge region has a role in facilitating the bridging between an antigenic target cell and effector cell. In a second IgG engineering approach, potential cancer vaccines that feature the Fc region of IgG fused to the tumour associated cancer-testis antigen, MAGE-A, were generated and tested. Such vaccines are designed to promote formation of immune complexes, which are preferentially taken up by dendritic cells via their FcRn receptors, with the aim of stimulating a strong anti-tumour immune response. Human MAGE-A2 fused to either human IgG1 Fc or mouse IgG2a Fc had been successfully produced and purified using Protein-G Sepharose. Results from Coomassie staining and western blotting analyses suggested that the Fc fusion proteins were suffering from protein aggregations and possibly protein degradations. To test if MAGE-A2 Fc fusion protein can be a potential cancer vaccine, an 8 amino acid peptide sequence, SIINFEKL, was incorporated into MAGE-A2 protein of the Fc fusion protein containing mouse IgG2a Fc. IgG-immune complexes of SIINFEKL incorporated Fc fusion protein were incubated with bone marrow derived dendritic cells (BMDC) and corresponding cytotoxic T cells, B3Z, to investigate the induction of antigen cross presentation. Unfortunately, SIINFEKL incorporated Fc fusion protein was unable to activate B3Z T cells. Further investigation showed that BMDC seems to have a low expression of FcRn receptor, which is crucial for inducing an effective antigen cross presentation, and might be the reason for the unsuccessful antigen cross presentation assay. As a result, further investigations are required to determine if MAGE-A2 Fc fusion protein can be a potential cancer vaccine. More studies are also required to understand the characteristics of MAGE-A2 Fc fusion protein to minimise protein aggregations or protein degradations.
46
Li, Jichun. "Tissue diagnosis probe based on stiffness measurement using vision and force sensing modalities." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/tissue-diagnosis-probe-based-on-stiffness-measurement-using-vision-and-force-sensing-modalities(2157fcfd-4155-43c8-ab70-2d8fad7ee622).html.
Full textAbstract:
This thesis presents the creation of a novel tissue diagnosis probe based on the measurement of stiffness and force during mechanical tool-tissue interactions. The probe using force and vision sensing modalities was created to be used for tissue diagnosis in medical applications, especially for robot-assisted minimallyinvasive surgery (MIS) to provide the necessary sensing modalities to allow for haptic feedback. By employing the developed prototypes, estimations of the mechanical properties of ex-vivo human prostate tissues were conducted using the finite element analysis (FEA) method and the Newton-Raphson algorithm. A clinical study of prostate tumour identification has been carried out on ex-vivo prostate samples and a study onrobotic palpation using a second prototype developed as part of this projectand comparing it to manual palpation was conducted. With the aim of measuring the indentation depth and the corresponding tissue reaction force simultaneously to obtain stiffness information,aprototype of a stiffness probe was constructedconsisting of a commercial digitalcamera and a force sensor. The effectiveness and sensitivityof the designedprobe was validatedthrough experiments on silicone phantomsand animal organs. The results showed that the probe could perform stiffness measurementsand localize tissue abnormalitieswhen indenting or sliding over the target surfaces. In order to investigate the mechanical properties of ex-vivo human prostate using the developed probe, a portable sliding indenter robot integrating the probe and the Phantom Omni device was created. Based on force-displacement measurements of the probe-soft tissue interaction, inversefinite element analysis (FEA)andthegeneralised Newton-Raphson algorithm were used to estimateunknown parameters including the shear modulus ofthe ex-vivo human prostate. The prostate was modelled as a nonlinear hyperelastic material (utilizing Arruda-Boyce model) inthe finite element modelling software package, ABAQUS 6.8-1. The results indicated that the proposed model can estimate the mechanical properties ofthe ex-vivo human prostate effectively. With the aim of identifying the stiffness of normal and cancerous prostate tissue, the prostates of 26 male patients were examinedusing the developed sliding indenter robot. Threedimensional (3D) stiffness maps of ex-vivo human prostate were created. The stiffness maps were correlatedwith other clinical examinations including Magnetic Resonance Imaging (MRI), Digital Rectal Examination (DRE), histology and Ultrosound-guided biopsy. The proposedprobe proved to be a promising platform to distinguish between cancerous and healthy tissue in prostate andto discriminate pathological tissue variations. In addition, the results provided quantitative information for the diagnosis and localization of prostate cancer. To ensure the proposed probe is suitable for MIS applications, a furtherprototype of the stiffness probebased on optic-fibreforce sensing replacing the commercial available force sensor was created. A study on robotic palpation using the developed probe and comparing it tomanual palpation was conducted. The results indicated that robotic palpation was more effective than manual palpation conducted by experienced surgeons.
47
Karl, Mičkei. "Prostor u videoigrama kao novi oblik scenske arhitekture." Phd thesis, Univerzitet u Novom Sadu, Fakultet tehničkih nauka u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=110167&source=NDLTD&language=en.
Full textAbstract:
Ovaj rad ima za cilj da ispita prisutnost i značaj videoigara ukontekstu scenske arhitekture i da ukaže na rastući značaj jedne mladediscipline, a to je kreiranje prostora u videoigrama. Teorijski inaučno-istraživački deo rada ukazuju, svaki na svoj način, na većpostojeće i nove moguće oblike primene koncepata prostora i vizuelnihpercepcija iz oblasti arhitekture i urbanizma u oblasti kreiranjavideoigara. Od Vitruvijevog trojnog načela, preko trojnog načelaključnih odrednica videoigara i problematike prostornih situacija,do uloge i položaja korisnika/igrača u kontekstu sadejstva sa datimprostorom, u radu je predočen niz načina na koje elementiarhitektonskog teorijskog nasleđa, pre svega elementi i principiscenske arhitekture, mogu biti implementirani u proces kreiranjaprostora u videoigrama.<br>The goal of this thesis is to examine the presence and significance ofvideogames in the context of scene architecture and to indicate a growingimportance of a young field – level design in videogames. Theoretical andscientific research portions of the paper point, each in their own manner, toexisting as well as new modes of applying concepts of space and visualperception from the domain of architecture and urbanism in the field ofvideogame design. This paper offers a significant number of methods ofimplementing aspects of architectural theory heritage, primarily elements andprinciples of scene architecture, in the process of designing space invideogames - starting with Vitruvius’s triple principle, followed by the tripleprinciple of key features of videogames and the issue of spatial situations, tothe role and position of user/player in the context of cooperation with a givenspace.
48
Alamerew, Yohannes Admassu. "Économie Circulaire et Logistique Inverse : Assistant de Prise de Décision pour la Récupération de Ressources en Fin de vie." Thesis, Université Grenoble Alpes, 2020. http://www.theses.fr/2020GRALI022.
Full textAbstract:
L'économie circulaire (EC) est considérée comme l'une des principales stratégies permettant d'atteindre les objectifs de développement durable (ODD). Cependant, les entreprises rencontrent des difficultés dans la mise en place de l’économie circulaire. Elles doivent faire face à des défis au niveau des modèles économiques, la mise en place d’outils et indicateurs. Ces derniers visent à évaluer les stratégies de circularité et de mesurer les performances des systèmes de logistique inverse. Il existe peu d'études sur l'évaluation de ces stratégies au niveau d'un produit, d'une chaîne d'approvisionnement ou d'un service. L'objectif principal de cette thèse de doctorat consiste à proposer des méthodes et des outils permettant d’évaluer les stratégies de circularité et de mesurer les performances du processus de logistique inverse. L'étude commence par l'identification des facteurs et des indicateurs de circularité nécessaires pour la prise de décision. Ensuite, la modélisation du système de logistique inverse est réalisée pour comprendre l'interaction complexe entre les variables de décision. Ainsi, une méthode, un outil et des indicateurs d'évaluation de l'économie circulaire ont été mis au point pour aider les entreprises à prendre des décisions. Enfin, une étude de cas avec plusieurs sociétés est réalisée pour examiner, valider et démontrer la pertienence du modèle, des outils et des indicateurs proposés. Les principales contributions de cette thèse incluent : * une taxonomie des variables décisionnelles et des indicateurs d'économie circulaire pour la logistique inverse, * Un modèle de dynamique de système pour tenir compte de la complexité du processus de logistique inverse afin de comprendre l'interaction complexe entre les variables de décision en fin de vie, * Un indicateur d'économie circulaire pour la logistique inverse qui mesure la performance des produits dans le système de logistique inverse, * Une méthode d'évaluation de l'économie circulaire pour évaluer les avantages environnementaux et économiques potentiels de la transformation des activités d'une entreprise vers l’économie circulaire, * Un outil d'évaluation de l'économie circulaire pour évaluer les stratégies de circularité des produits en fin de vie, et * Une analyse systématique de l'interaction entre diverses disciplines, y compris la chaîne d'approvisionnement inverse et le modèle économique de l’entreprise ; la conception de produits et services ; l’utilisation des produits et services ; les stratégies des processus de traitements de fin de vie dans le domaine de la recherche sur l’économie circulaire. Les résultats de cette thèse aident les industriels à prendre des décisions en matière de gestion des produits après leur phase d’utilisation. Les contributions de cette étude soutiennent la transition vers des stratégies d’économie circulaire plus durable<br>The Circular Economy (CE) is perceived as one of the main instruments to achieve sustainable development goals (SDGs). Even though companies are showing increasing interest to transform their businesses into a circular economy model, they are experiencing difficulties due to a lack of methods, tools, and indicators to assess circularity strategies and to measure the performance of reverse logistics systems. There are limited studies on the assessment of CE strategies of a product, supply chain, and service at the micro-level. The main objective of this Ph.D. thesis is to propose methods and tools to evaluate circularity strategies and measure the performance of reverse logistics. The study begins with identifying decision-making factors and indicators. Afterward, modeling of the reverse logistics system is accomplished to understand the complex interaction among decision variables. Then a circular economy assessment method, tool, and indicators have been developed to assist companies in the decision-making process. A case study with multiple companies is performed to examine, validate and demonstrate the applicability of the proposed model, tools and indicators. The main contributions of this Ph.D. thesis include: * a taxonomy of decision-making variables and circular economy indicators for reverse logistics, * a system dynamics model to represent the complex system of reverse logistics system in order to understand the complex interaction among end-of-life decision variables, * a circular economy indicator for reverse logistics that used to measure the performance of products in reverse logistics system, * a circular economy assessment method to evaluate the potential environmental and economic benefits of transforming a firm into a circular business, * a circular economy assessment tool to evaluate circularity strategies of end-of-life products, and * a systematic analysis of the interplay among diverse disciplines including reverse supply chain, business model; product and service design; product and service use; policy and end-of-life (EoL) treatment in circular economy research. The findings of this PhD work assist industrial practitioners in decision-making on the management of post-used products. The contributions of this Ph.D. thesis deemed to support the transition towards a more sustainable circular economy
49
Collis, Olivari Lucas. "Intensity mapping : a new approach to probe the large-scale structure of the Universe." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/intensity-mapping-a-new-approach-to-probe-the-largescale-structure-of-the-universe(cd5b7586-7210-441e-838f-545d397893e5).html.
Full textAbstract:
Intensity mapping (IM) is a new observational technique to survey the large-scale structure of matter using emission lines, such as the 21 cm emission line of atomic hydrogen (HI) and the rotational lines of the carbon monoxide molecule (CO). Sensitive radio surveys have the potential to detect the HI power spectrum at low redshifts (z <1) in order to constrain the properties of dark energy and massive neutrinos. Observations of the HI signal will be contaminated by instrumental noise and, more significantly, by astrophysical foregrounds, such as the Galactic synchrotron emission, which is at least four orders of magnitude brighter than the HI signal. In this thesis, we study the ability of the Generalized Needlet Internal Linear Combination (GNILC) method to subtract radio foregrounds and to recover the cosmological HI signal for HI IM experiments. The GNILC method is a new technique that uses both frequency and spatial information to separate the components of the observed data. For simulated radio observations including HI emission, Galactic synchrotron, Galactic free-free, extragalactic point sources and thermal noise, we find that it can reconstruct the HI plus noise power spectrum with 7.0% accuracy for 0.13 <z <0.48 (960 - 1260 MHz) and l <400. In this work, GNILC is also applied to a particular CO IM experiment: the CO Mapping Array Pathfinder (COMAP). In this case, the simulated radio observations include CO emission, Galactic synchrotron, Galactic free-free, Galactic anomalous microwave emission, extragalactic point sources and thermal noise. We find that GNILC can reconstruct the CO plus noise power spectra with 7.3% accuracy for COMAP phase 1 (l <1800) and 6.3% for phase 2 (l <3000). In both cases, we have 2.4 <z <3.4 (26 - 34 GHz). In this work, we also forecast the uncertainties on cosmological parameters for the upcoming HI IM experiments BINGO (BAO from Integrated Neutral Gas Observations) and SKA (Square Kilometre Array) phase-1 dish array operating in auto-correlation mode. For the optimal case of BINGO with no foregrounds, the combination of the HI angular power spectra with Planck results allows w to be measured with a precision of 4%, while the combination of the BAO acoustic scale with Planck gives a precision of 7%. We consider a number of potentially complicating effects, including foregrounds and redshift dependent bias, which increase the uncertainty on w but not dramatically; in all cases the final uncertainty is found to be less than 8% for BINGO. For the combination of SKA-MID in auto-correlation mode (total-power) with Planck, we find that, in ideal conditions, w can be measured with a precision of 4% for the redshift range 0.35 <z <3 (350 - 1050 MHz) and 2% for 0 <z <0.49 (950 - 1421 MHz). Extending the model to include the sum of neutrino masses yields a 95% upper limit of less than 0.30 eV for BINGO and less than 0.12 eV for SKA phase 1, competitive with the current best constraints in the case of BINGO and significantly better in the case of SKA.
50
White, Lee Francis. "Combined nanostructural and isotopic analysis of baddeleyite : new horizons in solar system chronology." Thesis, University of Portsmouth, 2017. https://researchportal.port.ac.uk/portal/en/theses/combined-nanostructural-and-isotopic-analysis-of-baddeleyite(80e4ee98-4090-4801-90f3-ce122bc9270a).html.
Full textAbstract:
Baddeleyite (monoclinic-ZrO2) is an exceptionally common accessory phase in many of the mafic and ultra-mafic rocks prevalent throughout the Solar System. This study presents the first ground-truthing efforts in the development of this robust mineral into a diagnostic indicator, discrete barometer, and precise U-Pb geochronometer of shock metamorphism by combining electron backscatter diffraction and atom probe tomography to generate unique chemical and structural datasets. Microstructural analysis of variably shocked baddeleyite grains around the Sudbury impact structure (Ontario, Canada) highlights a series of crystallographic structures that can be correlated with discrete variations in formative pressure-temperature conditions. Decompression at high temperatures generates a series of interlocking reversion twinned structures, while quenching forms a quasi-amorphous matrix. These features are comparable to those observed in extra-terrestrial samples, where they can be directly linked with the severity and extent of lead loss and age resetting. This finding facilitates the application of baddeleyite as a shock indicator, barometer (>5 GPa) and chronometer in a wide range of planetary materials. This structural variability is also observable on the nanometre scale. Analysis of the most highly shocked Sudbury baddeleyite using atom probe tomography reveals planar and curvi-planar fractures, trace element enriched subgrain boundaries, and solid-state diffusion clusters. These micrometre and nanometre scale features encourage localised diffusion of lead, with whole-microtip U-Pb analyses yielding complex partially reset ages. The application of atom probe tomography allows these features to be spatially resolved on the nanometre scale, yielding highly accurate ages for protolith crystallization and impact metamorphism within a single grain. These results have significant implications for the isotopic analysis of baddeleyite-bearing planetary materials, where the mechanisms of U-Pb age resetting have until now been poorly understood.