Academic literature on the topic 'PROSPECT+SAIL model'

There are several contextual, historical approaches to texts. They include much hermeneutics, reception theory, and the new historicism. Yet, in the history of political philosophy, the contextual approach is associated narrowly with J. G. A. Pocock, Quentin Skinner, and the Cambridge School they are often said to have inspired. This article examines the rise of this contextualism, the theoretical arguments used to justify it, and its current standing and future prospects. It pursue several arguments. First, the label “Cambridge School” is highly misleading: Pocock and Skinner differ significa

Progressive neuronal loss is a typical characteristic of neurodegenerative diseases. In Parkinson’s disease, the loss of dopaminergic neurons in the basal ganglia results in impaired mobility and flawed muscle control. The loss of cholinergic neurons largely in the basal forebrain contributes to memory and attention deficits and the overall cognitive impairment in Alzheimer’s disease. This being said, neuroprotective drugs should be expected to preserve and/or restore the functions affected by neuronal loss, and substantially prevent cell death. The endocannabinoid system, comprising lipid mediators able to bind to and activate cannabinoid receptors, has emerged as a therapeutic target of potential interest in a variety of central nervous system diseases. Palmitoylethanolamide (PEA) is one of the most important endocannabinoids, which has a key role in modulating oxidative stress and inflammatory response with neuroprotective potential in neurological disorders. Neurodegenerative diseases undergo varied, progressive stages. The current therapeutical approaches are beginning to fall short when it comes to meet the expected results, urging to either develop or identify or develop new effective treatments. This chapter discusses the neuroprotective potential of new drugs, aiming to shed some light on their proposed mechanism of action and their effect in cellular and animal models of neurodegeneration.