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Dissertations / Theses on the topic 'Prostaglandin E receptor EP2'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Lee, Jinju. "IL-23 generates pathogenic Th17 cells by triggering T cell-intrinsic prostaglandin E2-EP2/4 signaling." Kyoto University, 2018. http://hdl.handle.net/2433/235123.

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2

Sonoshita, Masahiro. "Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc[Δ716] knockout mice". Kyoto University, 2004. http://hdl.handle.net/2433/147468.

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3

Seno, Hiroshi. "Cyclooxygenase 2- and prostaglandin E2 receptor EP2-dependent angiogenesis in ApcΔ716 mouse intestinal polyps". Kyoto University, 2002. http://hdl.handle.net/2433/149346.

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4

Inazumi, Tomoaki. "Roles of Prostaglandin EP4 Receptor in Adipocytes." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188727.

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5

Soontrapa, Kitipong. "Prostaglandin E2-prostaglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression." Kyoto University, 2013. http://hdl.handle.net/2433/170077.

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6

Chandramouli, Anupama. "The Role of Prostaglandin E2/EP4 Prostanoid Receptor Signaling in Colorectal Carcinogenesis." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/195443.

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Colorectal cancer, among other tumors, is characterized by elevated levels of prostaglandins due to the up-regulation of cyclooxygenase -2 (COX-2), a key enzyme in the eicosanoid biosynthesis pathway. Prostaglandin E2 (PGE2) is an important prostaglandin that exerts its biological function via four transmembrane G protein coupled receptors (EP1-4), among which the EP4 receptor is the most important. The relevance of EP4 receptor to the carcinogenic process and the consequences of its interaction with PGE2 were explored in this dissertation.Despite the importance of the EP4 receptor in colon ca

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7

Furuyashiki, Miyako. "Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1." Kyoto University, 2009. http://hdl.handle.net/2433/126454.

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8

Kunikata, Tomonori. "Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3." Kyoto University, 2005. http://hdl.handle.net/2433/144482.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第11827号<br>医博第2903号<br>新制||医||906(附属図書館)<br>23587<br>UT51-2005-K493<br>京都大学大学院医学研究科脳統御医科学系専攻<br>(主査)教授坂口志文, 教授湊長博, 教授宮地良樹<br>学位規則第4条第1項該当

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9

Peng, Lin [Verfasser], and Udo [Akademischer Betreuer] Jeschke. "The role of G-protein coupled prostaglandin E2 receptors (EP2 and EP3) in unexplained recurrent miscarriage and cervical cancer / Lin Peng ; Betreuer: Udo Jeschke." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1239049366/34.

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10

Hori, Ryusuke. "PROSTAGLANDIN E RECEPTOR SUBTYPE EP4 AGONIST PROTECTS COCHLEAE AGAINST NOISE-INDUCED TRAUMA." Kyoto University, 2010. http://hdl.handle.net/2433/120543.

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11

Eckert, David. "The Prostaglandin E2 Receptor 1 (EP1) Antagonizes AngII in the Collecting Duct." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36196.

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Prostaglandin E2 (PGE2), a metabolite of arachidonic acid, plays a role in water and sodium reabsorption in the collecting duct of the kidney. The collecting duct is responsible for the fine tuning of water and electrolytes. Only a small fraction of the filtered water and sodium is reabsorbed in the collecting duct, a fraction crucial to the regulation of water and electrolyte balance. This current study addresses the role of EP1, one of four PGE2 receptors, in the collecting duct. It is well documented that PGE2 inhibits sodium and water reabsorption in the collecting duct, however the exact

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12

Wong, Chi-kin, and 黃志堅. "The role of prostaglandin E2 receptor EP4 subtype in energy balance and obesity." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48334236.

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Obesity features increased accumulation of fat in the body and results in adverse health consequences, including type II diabetes mellitus and cardiovascular diseases. The global epidemic of obesity and lack of effective treatments call for the search of new anti-obesity medication. Activation of prostaglandin receptor subtype 4 (EP4) had been shown to produce potent anti-inflammatory effect and possibly induce brite adipocytes to increase energy expenditure, both of which can potentially ameliorate obesity. The purpose of this dissertation is to characterize the metabolic phenotypes of EP4 r

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13

Yasui, Mika. "The Prostaglandin E2 Receptor EP4 Regulates ObesityーRelated Inflammation and Insulin Sensitivity". Kyoto University, 2016. http://hdl.handle.net/2433/215455.

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14

Nojima, Shingo. "Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263574.

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15

Nakamura, Kazuhiro. "Physiological roles and molecular functions of prostaglandin EP3 receptor in the nervous system." 京都大学 (Kyoto University), 2002. http://hdl.handle.net/2433/150101.

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16

Kitaoka, Shiho. "Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum." Kyoto University, 2008. http://hdl.handle.net/2433/135927.

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17

Ehrlich, Aliza Toby. "The dissection of the molecular mechanism underlying the facilitative action of prostaglandin E receptor EP1 on dopamine D1 receptor-induced cAMP production." 京都大学 (Kyoto University), 2013. http://hdl.handle.net/2433/180537.

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18

Nakamura, Yoshiko. "Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus." Kyoto University, 2007. http://hdl.handle.net/2433/135896.

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19

Kabashima, Kenji. "The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut." Kyoto University, 2003. http://hdl.handle.net/2433/148729.

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20

Yoshida, Keiji. "Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation." Kyoto University, 2002. http://hdl.handle.net/2433/149332.

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21

Hassouneh, Ramzi. "Prostaglandin E2 Receptor 3 (EP3) Contributes to Polyuria, Glomerular Hyperfiltration, and Renal Injury in Diabetes." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32773.

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Cyclooxygenases (COXs) and their main renal product, prostaglandin E2 (PGE2), regulate many physiological renal functions and are involved in the pathogenesis of diabetic kidney disease. The PGE2 receptor EP3 has been repeatedly shown to be upregulated during diabetes. Physiologically, EP3 is best recognized to act as a diuretic by antagonizing arginine-vasopressin (AVP)-mediated water reabsorption. Incidentally, the first renal manifestation of diabetes is polyuria, which may trigger a cascade of events leading to DN. We hypothesize that EP3 contributes to polyuria and kidney dysfunction duri

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22

Elander, Louise. "Prostaglandin E2 in Brain-mediated Illness Responses." Doctoral thesis, Linköpings universitet, Cellbiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-53701.

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We are unceasingly exposed to potentially harmful microorganisms. The battle against threatening infectious agents includes activation of both the innate and of the adaptive immune systems. Illness responses are elicited and include inflammation, fever, decreased appetite, lethargy and increased sensitivity to painful stimuli in order to defeat invaders. While many of these signs of disease are controlled by the central nervous system, it has remained an enigma how signals from the peripheral immune system reach the brain through its blood-brain barrier, which precludes macromolecules, includi

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23

Koga, Marianna Mainardi. "O PAF como regulador endógeno do fenótipo e função das células dendríticas." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-24022016-142347/.

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Neste trabalho nós mostramos que células dendríticas (DCs) de camundongos BALB/c expressam receptor para o PAF (Fator ativador de Plaquetas) e que sua ativação promove um fenótipo tolerogênico, associado à produção de IL10 e PGE2. O bloqueio do PAF-receptor por antagonistas aumentou a capacidade das DCs induzirem proliferação de linfócitos T. O antagonista WEB2170 potencializou a resposta imune in vivo a concentração de anticorpo IgG2a OVA-específico aumentou 30 vezes no grupo tratado; a concentração de IgG1 foi semelhante nos dois grupos. O bloqueio do PAFR em camundongos imunizados com OVA

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24

Gomes, Renata Nascimento. "Análise do perfil dos prostanoides e do seu papel no controle da migração celular em glioblastoma." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-23012017-094918/.

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O glioblastoma (GBM) é o tumor mais frequente do sistema nervoso central com um alto grau de malignidade e um prognóstico desfavorável. Apesar dos avanços nas técnicas cirúrgicas e de radioterapia e/ou quimioterapia, não há tratamento eficiente disponível para o GBM. Os prostanoide são derivados do ácido araquidônico e estão envolvidas com vários processos do desenvolvimento e progressão do câncer. O objetivo deste estudo foi analisar in vitro o perfil de diferentes prostanoides nas linhagens de GBM. Além de analisar o papel dos prostanoides e dos receptores na migração celular de GBM. Os resu

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25

Sakuma, Yoko. "Crucial involvement of the EP4 subtype of prostaglandin E (PGE) receptor in osteoclast formation by proinflammatory cytokines and lipopolysaccharide." Kyoto University, 2000. http://hdl.handle.net/2433/180871.

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26

Reschke, Cristina Ruedell. "RECEPTORES EP1 E EP3 MODULAM AS CRISES EPILÉPTICAS INDUZIDAS POR PENTILENOTETRAZOL E ÁCIDO CAÍNICO EM CAMUNDONGOS." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/3852.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Epilepsy is one of the most common neurologic disorders. It has been suggested that seizures may be facilitaded by inflammation. PGE2 is one of the most important inflammatory mediators, and facilitates pentylenetetrazol (PTZ)-induced seizures by stimulating EP1 and EP3 receptors. However, up to the present moment, no study has investigated whether EP1 and EP3 receptors blocking attenuate seizures induced by convulsants other than PTZ. It is also unknown whether Na+,K+-ATPase activity alterations are involved in such an effect. The

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27

Vidal, Sancho Laura. "Nou mecanismes implicats en els dèficits transcripcionals i la pèrdua del BDNF en la malaltia de Huntington: descripció de noves dianes terapèutiques." Doctoral thesis, Universitat de Girona, 2018. http://hdl.handle.net/10803/663460.

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Huntington disease is a neurodegenerative disorder characterized by motor, cognitive and psychiatric dysfunction. Huntington disease is caused by an expanded CAG trinucleotide repeat at the exon 1 of the IT15 gen, which encodes for the huntingtin protein. It has been determined that the presence of mutant huntingtin activates distinct pathological cellular mechanisms that generate neuronal dysfunction and lead to neuronal death. One of the central aims in Huntington disease research is the study of molecular alterations to find new therapeutic targets to stop or delay Huntington disease progre

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28

Thibodeau, Jean-François. "Prostaglandin E2 Signaling Through Kidney EP1 and EP4 Receptors; Implications in Diabetes and Hypertension." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32749.

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Chronic kidney disease is defined as the appearance of kidney functional or structural injury. Cyclooxygenase and prostaglandin E2 have been implicated in the pathogenesis of diabetic nephropathy, the leading cause of chronic kidney disease. Beneficial in certain settings, inhibition of the cyclooxygenase pathway can however be detrimental in patients with compromised cardiac or renal function. Moreover, the quest for new therapies to treat diabetic nephropathy is hampered by the lack of appropriate rodent models. This doctoral thesis is a culmination of three studies, the first to determine

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29

Hawcroft, Gillian, Paul M. Loadman, Andrea Belluzzi, and Mark A. Hull. "Effect of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signalling in human colorectal cancer cells." Neoplasia Press, 2010. http://hdl.handle.net/10454/4551.

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The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA), in the free fatty acid (FFA) form, has been demonstrated to reduce adenoma number and size in patients with familial adenomatous polyposis. However, the mechanistic basis of the antineoplastic activity of EPA in the colorectum remains unclear. We tested the hypothesis that EPA-FFA negatively modulates synthesis of and signaling by prostaglandin (PG) E(2) in human colorectal cancer (CRC) cells. EPA-FFA induced apoptosis of cyclooxygenase (COX)-2-positive human HCA-7 CRC cells in vitro. EPA-FFA in cell culture medium was incorpo

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30

Tamba, Shigero. "Molecular mechanism of prostaglandin E2-EP2 signaling in ovulation and fertilization." 京都大学 (Kyoto University), 2007. http://hdl.handle.net/2433/137131.

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31

Tsoi, Lo-yan Luc, and 蔡露茵. "Morphological and metabolic alternations in adipose tissue of EP4 deficient mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/198799.

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Obesity is a rising global health burden. The accumulation of fat in the body is associated with metabolic syndrome, type 2 diabetes, cardiovascular disease, hypertension and cancer. Currently available anti-obesity medications are not effective and safe to meet the medical need for obesity management. Prostaglandin E receptor subtype 4 (EP4) is involved in the development of adipocytes, but the signaling in adipogenesis and the effect on the regulation of energy homeostasis is not clear to understand. Thus, EP4 receptor and its signaling pathway are interest for research. The purpose of this

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32

Ratzlaff, Viviane. "Padronização e validação de um novo modelo de febre induzida pela injeção intratecal de prostaglandina e2 em ratos jovens." Universidade Federal de Santa Maria, 2006. http://repositorio.ufsm.br/handle/1/11148.

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The fever response, besides being part of host defense response to infection or inflammation, is associated with discomfort and anxiety and may constitute a risk for febrile seizures in children. Therefore, antipyretic therapy is routinely prescribed for febrile patients. The animal models of fever using the systemic injection of lipopolysaccharide (LPS) and Baker yeast, described in the literature, are suitable for screening of novel antipyretics, but they do not provide information regarding the mechanism of action of these compounds. Therefore, the present study aimed to describe and valida

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33

Rastogi, Shruti. "The Role of Prostaglandin E2 in causing susceptibility towards Anaphylaxis." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/21632.

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Die Ausbildung und der Schweregrad einer Anaphylaxie kann durch verschiedene Co-Faktoren beeinflusst werden. Zu diesen zählen die nichtsteroidalen Antiphlogistika (NSAIDs), die ihre Wirkung über die Inhibition der COX entfalten. Wie NSAIDs den Schweregrad der Anaphylaxie beeinflussen, ist bisher nicht genau bekannt. Interessanterweise zeigen Anaphylaxie-Patienten mit einer NSAID-Hypersensibilität niedrige Konzentrationen des regulatorischen Prostaglandins E2 (PGE2). Zudem zeigen ASA-tolerante und –intolerante Asthma-Patienten variable anaphylaktische Sensitivitäten. Anhand der vorliegenden A

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34

Kang, Kui Dong. "The influence of prostaglandin EP2 agonists and selected flavonoids on retinal cell death." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:0dc2e919-12fb-44b8-abea-26f93135918d.

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35

Kang, Xu. "Prostaglandin E2 in Oxidopamine-induced Neuronal Inflammation and Injury." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1491318171029971.

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36

Plaza, Almolda Judith. "Validación preclínica del receptor EP2 mastocitario como diana terapéutica antiasmática." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/385023.

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El asma es una enfermedad crónica de las vías respiratorias cuyo abordaje terapéutico actual no frena su progresión, y en ocasiones no revierte la sintomatología. El análisis de mecanismos endógenos de protección puede resultar en la identificación de nuevas dianas farmacológicas efectivas. Los estudios preclínicos realizados hasta ahora en nuestro laboratorio junto con evidencia clínica y básica de otros grupos, sugirieron la hipótesis de que la activación selectiva del receptor prostanoide EP2 de le la PGE2 inhibe la actividad mastocitaria, y consecuentemente reduce el proceso patológico res

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37

Dannewitz, Svenja. "Prostaglandin E2 regulates neutrophil survival via EP2/PKA/NR4A2 signalling in the context of COPD." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/11619/.

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Chronic Obstructive Pulmonary Disease (COPD) is a neutrophil-associated pulmonary condition that is accompanied by chronic inflammation. Neutrophil lifespan is typically controlled by constitutive apoptosis, but their prolonged persistence at inflammatory sites is implicated in COPD pathology. However, current COPD therapies are inadequate at targeting neutrophilia. Prostaglandin E2 (PGE2) is a potent pro-survival mediator in neutrophils that is increased in COPD. Therefore, PGE2 may contribute to neutrophilic accumulation in COPD lungs and the resolution of inflammation may be achieved by dec

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38

Ma, Xiaojun. "Definition of prostaglandin E2-EP2 signals in the colon tumor microenvironment that amplify inflammation and tumor growth." Kyoto University, 2016. http://hdl.handle.net/2433/215461.

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Final publication is available at http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=26018088<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医科学)<br>甲第19635号<br>医科博第73号<br>32671<br>京都大学大学院医学研究科医科学専攻<br>(主査)教授妹尾浩, 教授渡邊直樹, 教授椛島健治<br>学位規則第4条第1項該当

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39

Abrahão, Aline Corrêa. "Participação da Prostaglandina E2 e seus receptores na proliferação celular do carcinoma epidermóide de cabeça e pescoço." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-29032010-155216/.

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O carcinoma epidermóide de cabeça e pescoço (CECP) representa 6ª malignidade mais comum no mundo. Para melhor entender os mecanismos envolvidos na iniciação tumoral, progressão e metástase, é necessária a elucidação dos eventos moleculares que guiam esses processos. É também importante a investigação da interação e modulação das células tumorais e seu microambiente. A participação de agentes inflamatórios no desenvolvimento e manutenção do CECP pode ser resumida na superexpressão da cicloxigenase 2 (COX-2) e na secreção de prostaglandina E2 (PGE2) pelas células tumorais. A PGE2 ativa seus rece

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40

Ji, Ruyue. "Activation of novel signal transduction pathways by human EP1 prostanoid receptors: the G-protein coupled receptors for prostaglandin E2." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/193560.

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The EP1 prostanoid receptor is one of four subtypes whose cognate physiological ligand is PGE₂. It is in the family of G-protein coupled receptors and is known to activate Ca²⁺ signaling, although it is unclear if this is mediated by coupling to G(q/11). Likewise little is known about other aspects of EP1 receptor signaling. In this dissertation, multiple novel signal transduction pathways have been identified and characterized following the activation of EP1 prostanoid receptors. To study EP1 receptor dependent gene regulation, HEK-293 cells stably expressing EP1 receptor were created and cDN

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41

Miyamoto, Masatomo. "Simultaneous stimulation of EP2 and EP4 is essential to the effect of prostaglandin E2 in chondrocyte differentiation." Kyoto University, 2004. http://hdl.handle.net/2433/147477.

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42

Carvalho, Liliana Sofia Machado de. "Expression of cyclooxygenase enzymes and prostaglandin E2 receptors in inflammatory airway diseases." Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/6347.

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Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina<br>Aspirin-intolerant asthma (AIA) is a syndrome where the interplay between cyclooxygenase (COX) and lipoxygenase (LOX) pathways is evident and is characterized by several abnormalities in the regulation and biosynthesis of eicosanoid mediators and eicosanoid receptors. Several observations indicate the presence of a complex change in the arachidonic acid (AA) metabolism in patients who suffer from AIA. However, previous studies showed some discrepant results when upper and lower airways were analyzed, and there

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43

Honda, Tetsuya. "Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis." Kyoto University, 2007. http://hdl.handle.net/2433/135661.

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44

Stitt, Erin Maureen. "The Role of Podocyte Prostaglandin E2 and Angiotensin II Receptors in Glomerular Disease." Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19800.

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The incidence of chronic kidney disease (CKD) is increasing. CKD is characterized by a gradual decrease in renal function leading to end stage renal disease (ESRD). Damage to the glomerular podocytes, is one of the first hallmarks of CKD. We hypothesized that podocyte prostaglandin E2 (PGE2) receptors contribute to the progression of glomerular injury in models of CKD. To test this hypothesis, transgenic mice were generated with either podocyte-specific overexpression or deletion of the PGE2 EP4 receptor (EP4pod+and EP4pod-/- respectively). Mice were next tested in the 5/6 nephrectomy (5/6 Nx)

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45

Goupil, Eugénie. "Biased allosteric regulation of the Prostaglandin F2α receptor: from small molecules to large receptor complexes". Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117082.

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G protein-coupled receptors (GPCRs) represent the largest family of cell surface receptors, and thus some of the most important targets for drug discovery. By binding to the orthosteric site where endogenous ligands bind, agonists and antagonists differentially modulate signals sent downstream from these receptors. New evidence suggests that GPCRs possess topographically distinct or allosteric binding sites, which may differentially modulate agonist- and antagonist-mediated responses to selectively affect distinct signalling pathways coupled to the same receptor. These sites may either positiv

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46

Sugimoto, Yukihiko. "A Study for Structure and Function of the Prostaglandin E Receptor." 京都大学 (Kyoto University), 1994. http://hdl.handle.net/2433/73152.

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After publication of this thesis, the International Union of Pharmacology defined the classification of prostanoid receptors (Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev. 46: 205-229, 1994.). The type-E prostanoid receptors (EPs) have been subdivided into four subtypes, EP1, EP2, EP3 and EP4. The 'EP2' receptor referred in this thesis has been pharmacologically identified as 'EP4' receptor as reported by Nishigaki et al (Nishigaki N, Negis

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47

Anthony, Todd Lee 1965. "Localization and molecular signaling pathways of prostaglandin receptor subtypes in the eye." Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282743.

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The eicosanoids are derived from membrane fatty acids. Prostaglandins (PGs), produced from the metabolism of arachidonic acid, are members of the eicosanoid family. Prostaglandins exert a broad range of biological effects by interacting with plasma membrane-bound receptors that are coupled to guanine nucleotide-binding proteins (G proteins). The topical application of prostaglandins results in a long-lasting reduction in intraocular pressure (IOP) in mammalian eyes, including humans. The distribution and function of the prostaglandin receptor subtypes within the eye are not clearly understood.

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48

Kashmiry, Alaa Abbas. "Regulation of prostaglandin receptor expression in human monocytic cells following inflammatory activation." Thesis, University of Strathclyde, 2015. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=26614.

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Inflammatory cells such as monocytes can be activated by bacteria leading to the release of pro-inflammatory cytokines, particularly tumour necrosis factor-α (TNF-α) and interleukin-1 (IL-1β) which sequentially induce prostaglandin (PG) production. It has been shown that PGs, especially PGE2 and PGD2, can potently suppress the production of cytokines when added exogenously or produced endogenously by negative-feedback regulation. There are multiple receptor subtypes for these PGs and it is uncertain which subtypes are specifically involved in the suppression of cytokine production. Therefore,

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Hammond, Kate Elizabeth. "Prostaglandin receptor distribution and function in the rat peripheral and central nervous system." Thesis, University of Leicester, 2006. http://hdl.handle.net/2381/29952.

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Prostaglandin E2 (PGE2) is a chemical mediator of nociception that can evoke characteristic pain behaviour in animals after peripheral and spinal administration. The prostanoid is synthesised during tissue injury through activation of the arachidonic acid cascade, and its effects are mediated through binding to a family of specific G-protein coupled prostaglandin E (EP) receptors. The aim of the present study was to elucidate which EP receptors have an involvement in mediating the pronociceptive effects of PGE2 within the rat peripheral and central nervous system. Western blotting was used to

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Keightley, Margaret Claire. "Autocrine and paracrine regulation of endothelial cell function by F-Prostanoid receptor signalling." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4809.

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Endometrial adenocarcinoma, originating from the glandular epithelial cells of the uterine endometrial lining, is one of the most prevalent cancers amongst women in the Western world. The prostaglandin F2α (PGF2α) receptor (FP) is upregulated in endometrial adenocarcinoma. A previous microarray analysis of endometrial adenocarcinoma cells (Ishikawa) identified numerous targets of PGF2α-FP signalling including angiogenic factors, VEGF-A, FGF-2, CXCL1 and CXCL8 and antiangiogenic factors ADAMTS1. The regulation of VEGF-A, FGF-2, CXCL1 and CXCL8 was confirmed by previous studies using an in vitro

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