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Journal articles on the topic 'Prostaglandin F2-alpha Treatment'

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Published: 4 June 2021

Last updated: 7 September 2023

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1

Cocnata, Christina L. "Use of Prostaglandin F2 Alpha for Cyclophosphamide-Induced Hemorrhagic Cystitis." Journal of Pharmacy Technology 10, no. 5 (1994): 204–6. http://dx.doi.org/10.1177/875512259401000504.

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Objective: To examine the use of prostaglandin F2 alpha in treating cyclophosphamide-induced hemorrhagic cystitis. Data Sources: An English language literature search using MEDLINE 1982–1993 and bibliographic reviews of related textbooks and review articles. Study Selection: Articles containing pertinent information regarding the therapeutic use and effects of prostaglandin F2 alpha as a treatment for cyclophosphamide-induced hemorrhagic cystitis in humans. Data Extraction: Resources were evaluated and information was extracted independently. Data Synthesis: A review of human cases suggests th

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2

Ramagopal, M. V., and S. J. Mustafa. "Effect of adenosine and its analogues on calcium influx in coronary artery." American Journal of Physiology-Heart and Circulatory Physiology 255, no. 6 (1988): H1492—H1498. http://dx.doi.org/10.1152/ajpheart.1988.255.6.h1492.

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In the present study, we have investigated the changes in calcium influx during the relaxing responses to adenosine and its analogues. Calcium-45 influx was measured in bovine coronary artery rings in the presence of prostaglandin F2 alpha (10(-5) M) and KCl (50 and 100 mM). Prostaglandin F2 alpha and KCl caused increases in calcium influx. Prostaglandin F2 alpha produced a further contraction when added to rings maximally contracted with KCl (100 mM or higher), suggesting two different mechanisms for prostaglandin F2 alpha- and KCl-induced contractions. Similarly, a greater calcium influx was

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3

Flint, AP, HN Jabbour, and AS Loudon. "Oxytocin stimulates uterine prostaglandin F2 alpha secretion in red deer Cervus elaphus." Reproduction, Fertility and Development 6, no. 2 (1994): 269. http://dx.doi.org/10.1071/rd9940269.

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The prostaglandin F2 alpha analogue cloprostenol stimulates ovarian secretion of oxytocin in red deer hinds and Pere David's deer hinds, as in cattle and sheep, but the response of the uterus to administered oxytocin has not been studied in deer. In the present experiment, oxytocin administered intravenously caused an increase in circulating concentrations of 13,14-dihydro-15-keto prostaglandin F2 alpha from 186 +/- 35 to 404 +/- 34 pmol L-1 within 5 min; concentrations in saline-treated hinds were unchanged (150 +/- 12 and 164 +/- 12 pmol L-1 before and after treatment respectively). This sug

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4

Kawai, Y., and T. Ohhashi. "Prostaglandin F2 alpha-induced endothelium-dependent relaxation in isolated monkey cerebral arteries." American Journal of Physiology-Heart and Circulatory Physiology 260, no. 5 (1991): H1538—H1543. http://dx.doi.org/10.1152/ajpheart.1991.260.5.h1538.

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Effects of prostaglandin F2 alpha (PGF2 alpha) on isolated monkey and dog cerebral arteries were investigated to reevaluate PGF2 alpha's possible action on the endothelium. Low concentrations of PGF2 alpha ranging from 10(-11) to 10(-8) M produced a dose-dependent relaxation in the monkey arteries. PGF2 alpha (10(-7) M) produced a transient contraction followed by a small relaxation, whereas higher concentrations (greater than 10(-6) M) of PGF2 alpha induced only contractions. The PGF2 alpha-induced relaxation was not observed in the canine cerebral arteries. The PGF2 alpha-induced relaxation

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5

Eiler, H., C. S. Armstrong-Backus, and W. A. Lyke. "Desensitization of rabbit myometrium to oxytocin and prostaglandin F2 alpha." American Journal of Physiology-Endocrinology and Metabolism 257, no. 1 (1989): E20—E26. http://dx.doi.org/10.1152/ajpendo.1989.257.1.e20.

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The desensitizing effects of oxytocin (OT) and prostaglandin F2 alpha (PGF2 alpha) were investigated in the uteri of rabbits. Uterine motility was measured in anesthetized rabbits infused intravenously with either PGF2 alpha (50 micrograms/min) or OT (100 mU/min) alternately. The treatment sequence was saline (30 min), first drug (OT or PGF2 alpha, 90 min), second drug (OT if PGF2 alpha was first drug and vice versa, 90 min), and first drug (repeated) 60 min. Both OT and PGF2 alpha infusions increased motility approximately 200% within 5–10 min. Thereafter, motility decreased linearly to base-

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6

Fairclough, RJ, and TM Lau. "Hormonal control of concentrations of endometrial oxytocin receptors in the ewe." Reproduction, Fertility and Development 4, no. 3 (1992): 313. http://dx.doi.org/10.1071/rd9920313.

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Uterine oxytocin receptors have been shown to play a major role in the regulation of uterine prostaglandin F2 alpha release during the oestrous cycle and early pregnancy in sheep. The concentration of endometrial oxytocin receptors increases sharply from around Day 13 of the oestrous cycle to reach a maximum between Days 15 and 16. The high concentration of endometrial oxytocin receptors at this time coincides with the release of endogenous uterine prostaglandin F2 alpha during luteal regression and the maximum uterine prostaglandin F2 alpha response to an oxytocin stimulus. The concentration

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7

Gilbert, CL, TH Burne, JA Goode, PJ Murfitt, and SL Walton. "Indomethacin blocks pre-partum nest building behaviour in the pig (Sus scrofa): effects on plasma prostaglandin F metabolite, oxytocin, cortisol and progesterone." Journal of Endocrinology 172, no. 3 (2002): 507–17. http://dx.doi.org/10.1677/joe.0.1720507.

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In the pig, nest building occurs in the day preceding parturition (gestation=114--116 days). Nest building behaviour can be induced in pregnant, pseudopregnant and cyclic female pigs following injection of prostaglandin F2alpha. Here we investigated behaviour and endocrine changes after the administration of indomethacin, which inhibits cyclo-oxygenase enzymes and thus prostaglandin synthesis. In experiment 1, pregnant primiparous pigs (gilts) were blood sampled through jugular vein catheters every 20 min from 1000 h on day 113 of pregnancy and behaviour was recorded until birth. Two hours aft

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8

Jara-Gutiérrez, Álvaro, and Victoriano Baladrón. "The Role of Prostaglandins in Different Types of Cancer." Cells 10, no. 6 (2021): 1487. http://dx.doi.org/10.3390/cells10061487.

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The prostaglandins constitute a family of lipids of 20 carbon atoms that derive from polyunsaturated fatty acids such as arachidonic acid. Traditionally, prostaglandins have been linked to inflammation, female reproductive cycle, vasodilation, or bronchodilator/bronchoconstriction. Recent studies have highlighted the involvement of these lipids in cancer. In this review, existing information on the prostaglandins associated with different types of cancer and the advances related to the potential use of them in neoplasm therapies have been analyzed. We can conclude that the effect of prostaglan

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9

Southorn, B. G., and R. M. Palmer. "Inhibitors of phospholipase A2 block the stimulation of protein synthesis by insulin in L6 myoblasts." Biochemical Journal 270, no. 3 (1990): 737–39. http://dx.doi.org/10.1042/bj2700737.

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Insulin at a concentration close to the physiological range (100 mu-units/ml) stimulated protein synthesis in L6 myoblasts by 17%. Pre-treatment with the phospholipase A2 inhibitors mepacrine or dexamethasone prevented this stimulation and decreased the release of prostaglandin F2 alpha, implicating the action of phospholipase A2 and the subsequent metabolism of arachidonic acid to prostaglandins in the stimulation of protein synthesis by physiological doses of insulin. Higher concentrations of insulin (500-1000 mu-units/ml) stimulated protein synthesis in the presence of mepacrine or dexameth

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10

Stocco, CO, and RP Deis. "Participation of intraluteal progesterone and prostaglandin F2 alpha in LH-induced luteolysis in pregnant rat." Journal of Endocrinology 156, no. 2 (1998): 253–59. http://dx.doi.org/10.1677/joe.0.1560253.

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We examined the participation of the intraluteal levels of progesterone (P4) and prostaglandin F2 alpha (PGF2 alpha) in the induction of luteolysis by LH and its relationship with the induction of the 20 alpha-hydroxysteroid dehydrogenase activity (20 alpha-HSD). Subcutaneous administration of four doses of 10 microgram ovine LH (oLH) at 0800, 0900, 1000 and 1100 h on day 19 of pregnancy induced a decrease in the activity of the enzyme 3 beta-HSD 24 and 48 h after treatment and an increase in luteal 20 alpha-HSD activity 48 h after oLH treatment when compared with control rats. Intraluteal and

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11

Bello, A. A., A. A. Voh Jr, D. Ogwu, and L. B. Tekdek. "Progesterone profile of red Sokoto does treated with prostaglandin F2-alpha and progesterone sponges for clinical application." Sokoto Journal of Veterinary Sciences 20, no. 1 (2022): 59–62. http://dx.doi.org/10.4314/sokjvs.v20i1.8.

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Progesterone profiles of Red Sokoto does were evaluated for clinical application. Fifty-one Red Sokoto goats does were assigned into three groups: (a) prostaglandin F2-alpha (n = 17), and given double injection of prostaglandin F2-alpha at 12-days interval; (b) progesterone sponges (n = 17), and administered progesterone sponges, inserted for 12-days; and (c) control (n = 17), no treatment. Blood samples were collected from all groups from day 0 to 6, day 9, day 12 to 15, day 19, and day 21 to 23 for progesterone profile. Group A had four profiles: 1) does in luteal phase at first and second i

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12

Piltch, A., L. Sun, R. A. Fava, and J. Hayashi. "Lipocortin-independent effect of dexamethasone on phospholipase activity in a thymic epithelial cell line." Biochemical Journal 261, no. 2 (1989): 395–400. http://dx.doi.org/10.1042/bj2610395.

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In the cloned rat thymic endocrine epithelial cell line TEA3A1, treatment with dexamethasone leads to decreased levels of prostaglandin E2, prostaglandin F2 alpha, and thromboxane B2. Dexamethasone treatment also leads to a decrease of both calcium-dependent and calcium-independent phospholipase A2 activity measured in a cell-free assay. Dexamethasone-treated cells also have increased levels of lipocortin-I, a putative modulator of phospholipase A2 activity. The property of calcium-dependent binding of lipocortin to the particulate fraction was used to prepare cytosolic and particulate subcell

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13

Leigh, Olufisayo Oluwadamilare, Lukman Mustapha, Agbugba Chinyere Linda, and Adaeze Ezenwanyi Ibiam. "Timed Artificial Insemination: Pregnancy Rates in Sokoto Gudali Cattle Treated with Prostaglandin F2 Alpha at a Private Dairy Farm in Nigeria." ANIMAL PRODUCTION 20, no. 1 (2019): 1. http://dx.doi.org/10.20884/1.jap.2018.20.1.636.

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Pregnancy rates (PR) resulting from timed artificial insemination (TAI) with frozen semen were investigated in 192 Sokoto Gudali (SG) cattle following estrus synchronization under 11- and 12- day treatment intervals with prostaglandin F2 alpha (Estrumate®). Two-point inseminations at 60 h and 72 h post Estrumate® treatments were used. All cattle were randomly allocated to 2 groups i.e. A and B, such that each sub-group of A1, A2, B1 and B2 had sixteen (16) cows and thirty two (32) heifers. Furthermore, cattle in Groups A and B were administered double Estrumate® injections at 11- and 12-day in

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14

Yorio, T., R. D. Page, and L. W. Frazier. "Prostaglandin regulation of H+ secretion in amphibian epithelia." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 260, no. 5 (1991): R866—R872. http://dx.doi.org/10.1152/ajpregu.1991.260.5.r866.

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The role of prostaglandins in regulating H+ excretion in amphibian epithelia was investigated. The abdominal skin of the southern leopard frog Rana pipiens and the urinary bladder of the toad Bufo marinus were used to measure proton excretion across their mucosal surface. Prostaglandin F2 alpha (PGF2 alpha) produced a dose-dependent inhibition of H+ excretion across the frog skin. Frogs pretreated with ibuprofen (30 mg.kg-1.day-1 for 3 days) showed an enhanced proton excretion similar to that observed when frogs are placed in chronic metabolic acidosis. The number of mitochondria-rich cells, t

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15

Komori, K., R. R. Lorenz, and P. M. Vanhoutte. "Nitric oxide, ACh, and electrical and mechanical properties of canine arterial smooth muscle." American Journal of Physiology-Heart and Circulatory Physiology 255, no. 1 (1988): H207—H212. http://dx.doi.org/10.1152/ajpheart.1988.255.1.h207.

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The effects of nitric oxide and acetylcholine (ACh) were investigated on the electrical and mechanical properties of vascular smooth muscle cells of the canine mesenteric artery. Isolated tissues with or without the endothelium were contracted with prostaglandin F2 alpha. Nitric oxide caused comparable concentration-dependent relaxations in rings with and without endothelium. ACh induced concentration-dependent relaxations only in arteries with endothelium. The relaxations to both nitric oxide and ACh were inhibited by methylene blue or oxyhemoglobin. Either in the presence or absence of prost

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16

Hinds, LA. "Prostaglandin alone does not cause luteolysis in the non-pregnant tammar wallaby, Macropus eugenii." Reproduction, Fertility and Development 3, no. 1 (1991): 17. http://dx.doi.org/10.1071/rd9910017.

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At parturition in the tammar wallaby, Macropus eugenii, the process of luteolysis involves both prostaglandin and prolactin. Prolactin alone is luteolytic, but it has been unclear whether prostaglandin F2 alpha (PGF2 alpha) is also directly luteolytic. To examine this, three groups non-pregnant animals were studied on Day 26 after removal of pouch young (the day equivalent to parturition). Group 1 (controls) received saline injections on Days 25 and 26, Group 2 received saline on Day 25 and PGF2 alpha on Day 26, and Group 3 was pre-treated with bromocriptine (Parlodel LA, Sandoz) on Day 25 and

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17

Sheldrick, EL, and AP Flint. "Effect of continuous infusion of oxytocin on prostaglandin F2 alpha secretion and luteolysis in the cyclic ewe." Reproduction, Fertility and Development 2, no. 1 (1990): 89. http://dx.doi.org/10.1071/rd9900089.

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Circulating concentrations of 13,14-dihydro-15-keto PGF2 alpha (DHKF2 alpha), luteinizing hormone (LH) and prolactin (PRL) have been measured in cyclic ewes treated with continuous infusions of oxytocin, in order to investigate the mechanism by which the treatment delays luteal regression. Continuous infusion of oxytocin reduced prostaglandin F2 alpha (PGF2 alpha) secretion but had no detectable direct effect on LH or PRL. Oxytocin (3 nmol h-1 i.v.) given from Day 12 or 13 until Day 18 after oestrus delayed luteolysis, eight out of nine treated ewes not returning to behavioural oestrus until D

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18

Davis, John S., Xiaoying Hou, Dulce Maroni, et al. "Rapid Induction of Gene Expression in the Corpus Luteum Following In Vivo Treatment with Prostaglandin F2 Alpha." Biology of Reproduction 85, Suppl_1 (2011): 229. http://dx.doi.org/10.1093/biolreprod/85.s1.229.

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19

Kitanaka, Jun-ichi, and Akemichi Baba. "Effect of Dibutyryl Cyclic AMP-Treatment on Prostaglandin F2.ALPHA.-Stimulated Phosphoinositide Hydrolysis in Cultured Rat Astrocytes." Japanese Journal of Pharmacology 58, no. 2 (1992): 189–92. http://dx.doi.org/10.1254/jjp.58.189.

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20

Wagerle, L. C., P. A. DeGiulio, O. P. Mishra, and M. Delivoria-Papadopoulos. "Effect of dexamethasone on cerebral prostanoid formation and pial arteriolar reactivity to CO2 in newborn pigs." American Journal of Physiology-Heart and Circulatory Physiology 260, no. 4 (1991): H1313—H1318. http://dx.doi.org/10.1152/ajpheart.1991.260.4.h1313.

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This study investigates the effect of glucocorticoid treatment on the relationship between arteriolar PCO2 and cortical prostanoid production and on cerebrovascular responsiveness to elevated CO2 in newborn piglets. The response of pial arteries to hypercapnia (fractional inspired CO2 = 0.035 and 0.07) was studied in 18 anesthetized newborn piglets, 9 of which were pretreated with dexamethasone (2 mg.kg-1.day-1 for 36-48 h). Pial arterioles (77-122 microns diam) were monitored using a closed cranial window and intravital microscopy. Perivascular cerebrospinal fluid (CSF) was sampled from the c

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21

Matsuki, T., and T. Ohhashi. "Endothelium and mechanical responses of isolated monkey pulmonary veins to histamine." American Journal of Physiology-Heart and Circulatory Physiology 259, no. 4 (1990): H1032—H1037. http://dx.doi.org/10.1152/ajpheart.1990.259.4.h1032.

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Ring strips of monkey pulmonary veins precontracted with a high concentration of prostaglandin F2 alpha (PGF2 alpha) relaxed in a concentration-dependent manner in response to histamine. Treatment with mepyramine and/or famotidine attenuated the relaxation. 2-Pyridylethylamine (2PEA) and dimaprit caused relaxations in the precontracted preparations, which were inhibited by pretreatment with mepyramine and famotidine, respectively. Removal of endothelium reversed the histamine- and 2PEA-induced relaxations to dose-related contractions. On the other hand, the removal had no effect on the dimapri

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22

Ziyadeh, F. N., E. Kelepouris, and Z. S. Agus. "Relationships between calcium and chloride transport in frog skin glands." American Journal of Physiology-Renal Physiology 251, no. 4 (1986): F647—F654. http://dx.doi.org/10.1152/ajprenal.1986.251.4.f647.

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Frog skin gland, a furosemide-sensitive Cl(-)-secreting epithelium, exhibits Cl(-)-dependent Ca2+ secretion in response to stimulation by beta-adrenergic agonists. In this study, we further explored the relationships between Cl- and Ca2+ secretion in frog skin using 45Ca fluxes and short-circulating technique. On addition of isoproterenol (ISO) or 8-(p-chlorophenylthio)-cAMP, a significant positive correlation was demonstrated between Ca2+ secretion and Cl- secretion. Because Cl- transport in other Cl(-)-transporting epithelia may be modulated by prostaglandins or by changes in cytosolic Ca2+

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23

Tozzi, C. A., G. J. Poiani, N. H. Edelman, and D. J. Riley. "Vascular collagen affects reactivity of hypertensive pulmonary arteries of the rat." Journal of Applied Physiology 66, no. 4 (1989): 1730–35. http://dx.doi.org/10.1152/jappl.1989.66.4.1730.

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We studied the role of vascular collagen on the responsiveness of isolated pulmonary arteries to vasoactive agonists. Dose-response curves to prostaglandin F2 alpha, (PGF2 alpha), angiotensin II (ANG II), and norepinephrine (NE) and responses to a depolarizing concentration of KCl were obtained on rings of pulmonary artery from normal rats, chronically hypoxic (10% O2 for 10 days) rats, and chronically hypoxic rats treated with cis-4-hydroxy-L-proline (cHyp), an agent that blocks collagen accumulation. Treatment with this agent prevented the rise in pulmonary blood pressure normally seen durin

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24

Shah, Kunal B., Sudeshna Tripathy, Hepziba Suganthi, and Medhamurthy Rudraiah. "Profiling of Luteal Transcriptome during Prostaglandin F2-Alpha Treatment in Buffalo Cows: Analysis of Signaling Pathways Associated with Luteolysis." PLoS ONE 9, no. 8 (2014): e104127. http://dx.doi.org/10.1371/journal.pone.0104127.

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25

Voh, A. A., E. O. Oyedipe, V. Buvanendran, and J. Kumi-Diaka. "Estrus response of indigenous Nigerian Zebu cows after prostaglandin F2 alpha analogue treatment under continuous observations for two seasons." Theriogenology 28, no. 1 (1987): 77–99. http://dx.doi.org/10.1016/0093-691x(87)90188-9.

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26

Fujii, K., H. Kohrogi, H. Iwagoe, et al. "Evidence that PGF2 alpha-induced contraction of isolated guinea pig bronchi is mediated in part by release of tachykinins." Journal of Applied Physiology 79, no. 5 (1995): 1411–18. http://dx.doi.org/10.1152/jappl.1995.79.5.1411.

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To investigate whether prostaglandin F2 alpha (PGF2 alpha) stimulates the release of tachykinins and whether the tachykinins play a role in the PGF2 alpha-induced bronchial contraction, we examined the contractile response to PGF2 alpha in the presence or absence of a neutral endopeptidase (NEP) inhibitor phosphoramidon in the guinea pig main bronchus in vitro. Because NEP effectively cleaves tachykinins, we hypothesized that the inhibition of NEP would enhance a PGF2 alpha-induced bronchial contraction if PGF2 alpha stimulates the release of tachykinins. Phosphoramidon significantly enhanced

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27

Van Zoelen, E. J. J., P. H. J. Peters, G. B. Afink, et al. "Bradykinin-induced growth inhibition of normal rat kidney (NRK) cells is paralleled by a decrease in epidermal-growth-factor receptor expression." Biochemical Journal 298, no. 2 (1994): 335–40. http://dx.doi.org/10.1042/bj2980335.

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Normal rat kidney fibroblasts, grown to density arrest in the presence of epidermal growth factor (EGF), can be induced to undergo phenotypic transformation by treatment with transforming growth factor beta or retinoic acid. Here we show that bradykinin blocks this growth-stimulus-induced loss of density-dependent growth arrest by a specific receptor-mediated mechanism. The effects of bradykinin are specific, and are not mimicked by other phosphoinositide-mobilizing agents such as prostaglandin F2 alpha. Northern-blot analysis and receptor-binding studies demonstrate that bradykinin also inhib

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28

Gould, K. L., and T. Hunter. "Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity." Molecular and Cellular Biology 8, no. 8 (1988): 3345–56. http://dx.doi.org/10.1128/mcb.8.8.3345-3356.1988.

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We have shown previously that pp60c-src is a substrate for protein kinase C in vivo and that the target of protein kinase C phosphorylation in mammalian pp60c-src is serine 12. We now demonstrate that in addition to tumor promoters, all activators of phosphatidylinositol turnover that we have tested in fibroblasts (platelet-derived growth factor, fibroblast growth factor, serum, vasopressin, sodium orthovanadate, and prostaglandin F2 alpha) lead to the phosphorylation of pp60c-src at serine 12. In addition to stimulating serine 12 phosphorylation in pp60c-src, platelet-derived growth factor tr

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29

Gould, K. L., and T. Hunter. "Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity." Molecular and Cellular Biology 8, no. 8 (1988): 3345–56. http://dx.doi.org/10.1128/mcb.8.8.3345.

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We have shown previously that pp60c-src is a substrate for protein kinase C in vivo and that the target of protein kinase C phosphorylation in mammalian pp60c-src is serine 12. We now demonstrate that in addition to tumor promoters, all activators of phosphatidylinositol turnover that we have tested in fibroblasts (platelet-derived growth factor, fibroblast growth factor, serum, vasopressin, sodium orthovanadate, and prostaglandin F2 alpha) lead to the phosphorylation of pp60c-src at serine 12. In addition to stimulating serine 12 phosphorylation in pp60c-src, platelet-derived growth factor tr

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30

TAKAHASHI, KIYOHARU, MASAHIRO CHIBA, HIDESHI TAKAHASHI, and SHIGERU SATO. "Progesterone Levels, Induction of Estrus and Conception Rate in Cows with Persistent Corpus Luteum after Treatment with Prostaglandin F2^|^alpha;." Journal of the Japan Veterinary Medical Association 40, no. 4 (1987): 241–46. http://dx.doi.org/10.12935/jvma1951.40.241.

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31

Archbald, L. F., S. Constant, T. Tran, C. Risco, E. Klapstein, and J. Elliott. "Effect of sequential treatment with prostaglandin F2 alpha and/or oxytocin on estrus and pregnancy rate of lactating dairy cows." Theriogenology 42, no. 5 (1994): 773–80. http://dx.doi.org/10.1016/0093-691x(94)90445-o.

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32

Archbald, L. F., T. Tran, R. Massey, and E. Klapstein. "Conception rates in dairy cows after timed-insemination and simultaneous treatment with gonadotrophin releasing hormone and/or prostaglandin F2 alpha." Theriogenology 37, no. 3 (1992): 723–31. http://dx.doi.org/10.1016/0093-691x(92)90151-g.

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33

Miller, V. M., and P. M. Vanhoutte. "Endothelium-dependent contractions to arachidonic acid are mediated by products of cyclooxygenase." American Journal of Physiology-Heart and Circulatory Physiology 248, no. 4 (1985): H432—H437. http://dx.doi.org/10.1152/ajpheart.1985.248.4.h432.

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Arachidonic acid produces endothelium-dependent relaxation in canine arteries and endothelium-dependent contraction in veins. In canine femoral arteries, the relaxation is prevented by inhibitors of cyclooxygenase. To determine the role of cyclooxygenase in the contraction evoked by arachidonic acid in the veins, rings of canine femoral and intrapulmonary veins, with and without endothelium, were suspended in organ chambers and set at their optimum length for isometric tension measurements. In rings of femoral and pulmonary vein contracted with norepinephrine, arachidonic acid produced a conce

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34

Tesfamariam, B., G. T. Allen, D. Normandin, and M. J. Antonaccio. "Involvement of the "tethered ligand" receptor in thrombin-induced endothelium-mediated relaxations." American Journal of Physiology-Heart and Circulatory Physiology 265, no. 5 (1993): H1744—H1749. http://dx.doi.org/10.1152/ajpheart.1993.265.5.h1744.

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The mechanisms by which the serine protease, alpha-thrombin, mediates relaxations were examined in isolated dog and pig coronary arteries and dog saphenous veins. In rings of coronary arteries and saphenous veins contracted submaximally with prostaglandin F2 alpha or U46619, alpha-thrombin (0.1-10 nM) caused relaxations that were abolished by treatment with N omega-nitro-L-arginine (L-NNA) or removal of the endothelium, indicating that the relaxations were mediated by endothelium-derived nitric oxide. These relaxations were blocked by the thrombin active site inhibitor, MD-805, indicating the

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35

Thomas, C. P., M. J. Dunn, and R. Mattera. "Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways." Biochemical Journal 312, no. 1 (1995): 151–58. http://dx.doi.org/10.1042/bj3120151.

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The human leukaemic cell line K562 is a pluripotent stem cell with the potential to mature along a megakaryocytic or erythroid line. In these cells, thrombin and U46619 (9,11-dideoxy-9 alpha, 11 alpha-methanoepoxy prostaglandin F2 alpha), a thromboxane A2 analogue, increased intracellular Ca2+ in a rapid and concentration-dependent manner. The peak transient observed with both thrombin and U46619 was preserved upon stimulation in the absence of extracellular calcium and blunted with phorbol myristate acetate, suggestive of activation of phospholipase C. Short-term treatment with leupeptin abol

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36

Tamaoki, J., K. Isono, N. Sakai, T. Kanemura, and K. Konno. "Erythromycin inhibits Cl secretion across canine tracheal epithelial cells." European Respiratory Journal 5, no. 2 (1992): 234–38. http://dx.doi.org/10.1183/09031936.93.05020234.

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We studied the effect of the macrolide antibiotic erythromycin on bioelectrical properties of canine cultured tracheal epithelium under short-circuit conditions in vitro. Addition of erythromycin to the submucosal but not to the mucosal side dose-dependently decreased short-circuit current (Isc), the maximal decrease from the baseline value and the concentration required to produce a half-maximal effect (IC50) being 5.6 +/- 1.0 microA.cm-2 (mean +/- SE, p less than 0.001) and 18 microM, respectively. In contrast, other antibiotics including ampicillin, cephazolin and tetracycline were without

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Bello, A. A., A. A. Voh JR, D. Ogwu, and L. B. Tekdek. "Some Aspects of Reproductive Performance of Red Sokoto Goat Does Post Synchronization with Prostaglandin F2-Alpha And Progesterone Sponges." Nigerian Veterinary Journal 40, no. 4 (2021): 263–77. http://dx.doi.org/10.4314/nvj.v40i4.2.

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A study on reproduction of 52 Red Sokoto Goat (RSG) does was conducted to evaluate some aspects of their reproductive performance for clinical application and as an update. Does were randomly divided into 18, 18 and 16 as prostaglandin F2-alpha (PGF2α), progesterone sponges (P4S) and control groups respectively. Double injection protocol of PGF2α, 12-days apart, and P4S inserted for 12-days were used to synchronize oestrus, while the control group received no treatment. Thirteen bucks were used, seven as breeders and six as heat detectors. Oestrus detection employed visual observation and apro

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Sato, D., Z. F. Lai, N. Tokutomi, et al. "Impairment of Kit-dependent development of interstitial cells alters contractile responses of murine intestinal tract." American Journal of Physiology-Gastrointestinal and Liver Physiology 271, no. 5 (1996): G762—G771. http://dx.doi.org/10.1152/ajpgi.1996.271.5.g762.

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We examined developmental changes in responses of the isolated segment of the ileum of BALB/c mice treated with a monoclonal antibody (ACK2) to the receptor tyrosine kinase (Kit) for 4 days postnatally to pharmacological agents in vitro. Rhythmic contraction and relaxation of the isolated ileum started to appear on day 4 postpartum, and the sensitivity to acetylcholine (ACh) decreased gradually after birth. Treatment with ACK2 induced augmentation of contractile responses and receptor sensitivity of the longitudinal muscle of the ileum to ACh, bradykinin, and prostaglandin F2 alpha. ACh induce

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Landau, S., JA Houghton, JR Mawhinney, and EK Inskeep. "Protein sources affect follicular dynamics in ewes near the onset of the breeding season." Reproduction, Fertility and Development 8, no. 6 (1996): 1021. http://dx.doi.org/10.1071/rd9961021.

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The influence of source of protein during the luteal phase before a synchronized oestrus on the dynamics of follicular development, observed daily by ultrasonography, was assessed in ewes that were beginning the sexual season. Iso-nitrogenous amounts of soybean meal (SBM) or of a corn-gluten meal-ground-corn grain mixture (CGM-GC), or an iso-energetic amount of ground-corn grain (GC), were fed from four days before to four days after treatment with prostaglandin F2 alpha (PGF2 alpha). Feeding with SBM was associated with a higher frequency of short luteal phases (P < 0.02). Dynamics of foll

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Harkin, Christopher P., Antal G. Hudetz, William T. Schmeling, John P. Kampine, and Neil E. Farber. "Halothane-induced Dilatation of Intraparenchymal Arterioles in Rat Brain Slices." Anesthesiology 86, no. 4 (1997): 885–94. http://dx.doi.org/10.1097/00000542-199704000-00019.

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Background Halothane is a potent dilator of cerebral arteries. The predominant site of cerebrovascular resistance is thought to be intracerebral arterioles, and the effects of halothane on these vessels were not previously examined. This study compared the effects of halothane with those of the vasodilator and nitric oxide donor, sodium nitroprusside, on intraparenchymal microvessel responsiveness in a brain slice preparation. Methods Anesthetized Sprague-Dawley rats underwent thoracotomy and intracardiac perfusion and then were decapitated. Hippocampal brain slices were prepared and placed in

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Sahai, A., R. S. Sandler, G. Xu, J. A. Shayman, and R. L. Tannen. "Signal transduction events whereby PGF2 alpha inhibits the ammoniagenic response to acute acidosis." American Journal of Physiology-Renal Physiology 262, no. 6 (1992): F950—F956. http://dx.doi.org/10.1152/ajprenal.1992.262.6.f950.

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Subconfluent cultures of LLC-PK1 cells were incubated for 1 h in Krebs-Henseleit buffer (KHB) of pH 7.4 or 6.8 to investigate the signal transduction events associated with prostaglandin F2 alpha (PGF2 alpha) inhibition of ammonia metabolism. Exposure of these cultures to PGF2 alpha (0.1 ng/ml) inhibited the acute low pH stimulation of ammonia production and to a lesser degree alanine formation in a manner analogous to the response exhibited with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). Pretreatment with an inhibitor of protein kinase C [1-(5-isoquinolinylsulfonyl)-2-methy

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Miller, V. M., and P. M. Vanhoutte. "17 beta-Estradiol augments endothelium-dependent contractions to arachidonic acid in rabbit aorta." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 258, no. 6 (1990): R1502—R1507. http://dx.doi.org/10.1152/ajpregu.1990.258.6.r1502.

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Experiments were designed to determine the effects of chronic estrogen treatment on endothelium-dependent responses to arachidonic acid in the aorta of the rabbit. Ovariectomized rabbits were treated with either placebo or 17 beta-estradiol for 14 days. The aortas were removed, and rings cut from each blood vessel were suspended for measurement of isometric force. In rings contracted with a submaximal concentration of norepinephrine, endothelium-dependent contractions to arachidonic acid were augmented by estrogen treatment. Prostaglandin F2 alpha, E2, the thromboxane analogue U 46619, and pro

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Plush, Kate J., John R. Pluske, David S. Lines, Cameron R. Ralph, and Roy N. Kirkwood. "Meloxicam and Dexamethasone Administration as Anti-Inflammatory Compounds to Sows Prior to Farrowing Does Not Improve Lactation Performance." Animals 11, no. 8 (2021): 2414. http://dx.doi.org/10.3390/ani11082414.

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The aim of this experiment was to determine whether administration of an anti-inflammatory compound to sows prior to farrowing would, via reduced pain and inflammation, increase piglet survival and growth. At day 114 of gestation, multiparous sows were randomly allocated to one of the following treatments: Control (n = 43), which received 10 mL saline, NSAID (n = 55) which received 0.4 mg/kg meloxicam and SAID (n = 54) which received 0.1 mg/kg dexamethasone. Treatments were applied again on day 116 if farrowing had not occurred. There was no treatment effect on piglets born alive or dead from

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Tseng, C. M., and W. Mitzner. "Antagonists of EDRF attenuate acetylcholine-induced vasodilation in isolated hamster lungs." Journal of Applied Physiology 72, no. 6 (1992): 2162–67. http://dx.doi.org/10.1152/jappl.1992.72.6.2162.

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To evaluate the role of endothelium-dependent relaxing factor (EDRF) in acetylcholine- (ACh) induced vasodilation in the intact pulmonary circulation, we examined the effects of atropine and three EDRF antagonists that have been shown to be effective in vitro: nitro-L-arginine (NOARG), hemoglobin (Hb), and methylene blue (MB). We studied ACh-induced dilation after preconstriction with angiotensin II and prostaglandin F2 alpha (PGF2 alpha) in hamster lungs perfused with Krebs solution containing Ficoll (4 g/dl) and indomethacin (10 microM). In the constricted lungs with no blockers, infusion of

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45

Healy, DL. "Progesterone receptor antagonists and prostaglandins in human fertility regulation: a clinical review." Reproduction, Fertility and Development 2, no. 5 (1990): 477. http://dx.doi.org/10.1071/rd9900477.

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Progesterone receptor antagonists have been developed by substitutions at the 11-beta and 17 side-chain positions of the progestagen norethisterone. The most studied progesterone receptor antagonists are mifepristone (Mifegyne; Roussel-UCLAF; RU486) and ZK98734 and ZK98299 (Schering AG). These compounds bind avidly to the progesterone receptor and glucocorticoid receptor but have essentially no binding to the mineralocortocoid, oestrogen or androgen receptors. Mifepristone also binds avidly to albumin, resulting in a half-life of approximately 24 h after oral administration. Progesterone recep

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Headrick, J. P., and R. M. Berne. "Endothelium-dependent and -independent relaxations to adenosine in guinea pig aorta." American Journal of Physiology-Heart and Circulatory Physiology 259, no. 1 (1990): H62—H67. http://dx.doi.org/10.1152/ajpheart.1990.259.1.h62.

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Effects of endothelial removal and hypoxia on responses to adenosine, 5'-(N-ethylcarboxamido)-adenosine (NECA), 2-chloroadenosine, N6-cyclohexyladenosine (CHA), sodium nitroprusside, and acetylcholine were examined in guinea pig aortic rings. Rings contracted with 2 microM prostaglandin F2 alpha (PGF2 alpha) relaxed in a dose-dependent manner in response to all drugs. The order of potency of adenosine compounds was NECA greater than 2-chloroadenosine greater than adenosine greater than CHA. Endothelial rubbing potentiated the PGF2 alpha response by 11 +/- 3%, eliminated the acetylcholine (ACh)

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Toda, N. "Mechanism underlying responses to histamine of isolated monkey and human cerebral arteries." American Journal of Physiology-Heart and Circulatory Physiology 258, no. 2 (1990): H311—H317. http://dx.doi.org/10.1152/ajpheart.1990.258.2.h311.

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Cerebral artery strips obtained from Japanese monkeys partially contracted with prostaglandin F2 alpha responded to histamine with a relaxation that was attenuated by treatment with cimetidine or chlorpheniramine and was abolished by their combined treatment. Endothelium denudation suppressed the relaxation; the remaining relaxation was not influenced by the H1 antagonism but was abolished by the H2 antagonism. Treatment with methylene blue slowed the development of relaxation and, in the presence of cimetidine, depressed the magnitude of relaxation. Indomethacin did not alter the response. In

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Coleman, D. A., F. F. Bartol, and M. G. Riddell. "Effects of 21-day treatment with melengestrol acetate (MGA) with or without subsequent prostaglandin F2 alpha on synchronization of estrus and fertility in beef cattle." Journal of Animal Science 68, no. 10 (1990): 3300. http://dx.doi.org/10.2527/1990.68103300x.

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Sudeshna, Tripathy, Kumarasamy Anand, and Rudraiah Medhamurthy. "Analysis of 20alpha-hydroxysteroid dehydrogenase expression in the corpus luteum of the buffalo cow: effect of prostaglandin F2-alpha treatment on circulating 20alpha-hydroxyprogesterone levels." Reproductive Biology and Endocrinology 11, no. 1 (2013): 111. http://dx.doi.org/10.1186/1477-7827-11-111.

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50

Kleeberger, S. R., E. M. Wagner, G. K. Adams, A. M. Dannenberg, and E. W. Spannhake. "Effect of repeated antigen exposure on antigen-and mediator-induced bronchospasm in sheep." Journal of Applied Physiology 59, no. 6 (1985): 1866–73. http://dx.doi.org/10.1152/jappl.1985.59.6.1866.

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We studied the effects of repeated exposures of antigen on airway reactivity to mediators of anaphylaxis and immediate response to the antigen. Seven antigen-sensitive sheep were exposed to aerosols of Ascaris suum antigen 5 times biweekly; a control group of seven sheep underwent the same exposure regimen with saline vehicle. Sheep were assigned to experimental (Ascaris) or control groups so the distribution of animals with regard to bronchial reactivity to mediators was about the same. Airway reactivity was assessed by determining the effects of aerosolized histamine (10–1,000 micrograms), p

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