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Journal articles on the topic 'Prostaglandin'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Sirchak, Yelyzaveta S., Oleksandr O. Boldizhar, Yaroslav F. Filak, et al. "CHANGES IN PROSTAGLANDIN LEVELS IN BLOOD SERUM OF PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE ON THE BACKGROUND OF THE OSTEOCHONDROSIS OF THE SPINE AND OBESITY." Wiadomości Lekarskie 75, no. 10 (2022): 2497–500. http://dx.doi.org/10.36740/wlek202210134.

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The aim: To study the features of changes in the level of prostaglandins (I2 and F2α) in blood serum of patients GERD on the background of OH of the cervical and thoracic spine and obesity. Materials and methods: The examined patients included 56 patients with GERD and OH of the cervical and thoracic spine. All patients had their blood serum prostaglandin (Pg) F2α and 6-keto prostaglandin F1α (blood prostacyclin – Pg I2) levels examined using the method of immunoassay analysis. Results: In all patients with GERD and OH an excessive body weight or obesity of varying degrees was found while anal

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2

Kirchner, K. A. "Role of prostaglandins in renin suppression during acute potassium loading." American Journal of Physiology-Renal Physiology 248, no. 3 (1985): F360—F365. http://dx.doi.org/10.1152/ajprenal.1985.248.3.f360.

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Acute K loading suppresses plasma renin activity (PRA) and may alter prostaglandin biosynthesis. To determine whether the effect of K on PRA was modulated through changes in the prostaglandin system, dietary NaCl-restricted rats were infused with prostaglandin I2. PRA was then determined before and 90 min after a KNO3 infusion. Control rats received only the prostaglandin infusion. PRA increased in rats receiving prostaglandins alone. K loading prevented the increase in PRA. To further exclude prostaglandins in PRA suppression during K loading, the effects of K on PRA were determined during pr

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3

Jara-Gutiérrez, Álvaro, and Victoriano Baladrón. "The Role of Prostaglandins in Different Types of Cancer." Cells 10, no. 6 (2021): 1487. http://dx.doi.org/10.3390/cells10061487.

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The prostaglandins constitute a family of lipids of 20 carbon atoms that derive from polyunsaturated fatty acids such as arachidonic acid. Traditionally, prostaglandins have been linked to inflammation, female reproductive cycle, vasodilation, or bronchodilator/bronchoconstriction. Recent studies have highlighted the involvement of these lipids in cancer. In this review, existing information on the prostaglandins associated with different types of cancer and the advances related to the potential use of them in neoplasm therapies have been analyzed. We can conclude that the effect of prostaglan

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4

Martens, Matthew D., Amy S. Fernando, and Joseph W. Gordon. "A new trick for an old dog? Myocardial-specific roles for prostaglandins as mediators of ischemic injury and repair." American Journal of Physiology-Heart and Circulatory Physiology 320, no. 6 (2021): H2169—H2184. http://dx.doi.org/10.1152/ajpheart.00872.2020.

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The small lipid-derived paracrine signaling molecules known as prostaglandins have been recognized for their ability to modulate many facets of cardiovascular physiology since their initial discovery more than 85 years ago. Although the role of prostaglandins in the vasculature has gained significant attention across time, a handful of historical studies have also directly implicated the cardiomyocyte in both prostaglandin synthesis and release. Recently, our understanding of how prostaglandin receptor modulation impacts and contributes to myocardial structure and function has gained attention

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5

Codde, James P., and Lawrence J. Beilin. "Dietary fish oil prevents dexamethasone induced hypertension in the rat." Clinical Science 69, no. 6 (1985): 691–99. http://dx.doi.org/10.1042/cs0690691.

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1. This study was designed to examine the effect of dexamethasone treatment on tissue and urinary prostanoids, and to determine whether inhibition of prostaglandin biosynthesis by manipulation of dietary fatty acids accelerates the development of glucocorticoid hypertension. 2. Forty-eight rats were placed on either a 2-series prostaglandin ‘inhibitory’ diet (cod liver oil/linseed oil) or a control diet of saturated fat for an initial period of 4 weeks. The groups were then divided into two so that half of each received dexamethasone in their drinking water (2.5 mg/1) for 1 week whilst continu

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6

Leighton, B., L. Budohoski, F. J. Lozeman, R. A. J. Challiss та E. A. Newsholme. "The effect of prostaglandins E1, E2 and F2α and indomethacin on the sensitivity of glycolysis and glycogen synthesis to insulin in stripped soleus muscles of the rat". Biochemical Journal 227, № 1 (1985): 337–40. http://dx.doi.org/10.1042/bj2270337.

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Prostaglandins E1 and E2 increased the sensitivity of glycolysis to insulin in the isolated stripped soleus muscle of the rat, but prostaglandin F2 alpha had no effect. Indomethacin, which inhibits prostaglandin formation, markedly decreased the sensitivity of glycolysis to insulin. These findings suggest that prostaglandins of the E series increase the sensitivity of muscle glycolysis to insulin in vivo.

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7

Tiwary, Ekta, Muhan Hu, and Jeevan K. Prasain. "Sperm-Guiding Unconventional Prostaglandins in C. elegans: Synthesis and Signaling." Metabolites 11, no. 12 (2021): 853. http://dx.doi.org/10.3390/metabo11120853.

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Prostaglandins comprise a family of lipid signaling molecules derived from polyunsaturated fatty acids and are involved in a wide array of biological processes, including fertilization. Prostaglandin-endoperoxide synthase (a.k.a. cyclooxygenase or Cox) initiates prostaglandin synthesis from 20-carbon polyunsaturated fatty acids, such as arachidonic acid. Oocytes of Caenorhabditis elegans (C. elegans) have been shown to secrete sperm-guidance cues prostaglandins, independent of Cox enzymes. Both prostaglandin synthesis and signal transduction in C. elegans are environmentally modulated pathways

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8

Nassar, Bassam A., Yung-Sheng Huang, Alan T. J. McDonald, Kenneth D. Jenkins, and David F. Horrobin. "The influence of phenelzine and tranylcypromine on the release of prostaglandins from the rat mesenteric vascular bed." Canadian Journal of Physiology and Pharmacology 66, no. 9 (1988): 1206–9. http://dx.doi.org/10.1139/y88-198.

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We investigated the effects of phenelzine and tranylcypromine on the release of prostacyclin, thromboxane A2, prostaglandin E2, and prostaglandin E1 from the isolated perfused rat mesenteric vascular bed. Perfusion of the preparation with phenelzine in concentrations of 15, 45, and 135 μM for 150 min led to attenuated release of all four prostaglandins measured. Inhibition generally occurred with the lowest dose used and was most prominent with the highest concentration. Tranylcypromine also decreased prostaglandin formation. However, low doses were not effective in the suppression of prostacy

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9

Tsuchida, Keiichiro, Takae Ibuki, and Kiyoshi Matsumura. "Bromoenol Lactone, an Inhibitor of Calcium-Independent Phospholipase A2, Suppresses Carrageenan-Induced Prostaglandin Production and Hyperalgesia in Rat Hind Paw." Mediators of Inflammation 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/605727.

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Prostaglandin (PG) E2and PGI2are essential to hyperalgesia in inflammatory tissues. These prostaglandins are produced from arachidonic acid, which is cleaved from membrane phospholipids by the action of phospholipase A2(PLA2). Which isozyme of PLA2is responsible for the cleavage of arachidonic acid and the production of prostaglandins essential to inflammation-induced hyperalgesia is not clear. In this study, we examined the effects of two PLA2isozyme-specific inhibitors on carrageenan-induced production of PGE2and PGI2in rat hind paw and behavioral nociceptive response to radiant heat. Local

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10

Surbek, Hösli, and Holzgreve. "Current aspects of labor induction." Therapeutische Umschau 59, no. 12 (2002): 650–54. http://dx.doi.org/10.1024/0040-5930.59.12.650.

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Die Geburtseinleitung ist eines der wichtigsten therapeutischen Interventionsmittel in der Geburtshilfe und Schwangerschaftsmedizin. Das Ziel der Einleitung ist es, das bessere «perinatale Ergebnis» für Mutter und Kind im Gegensatz zum abwartenden Vorgehen zu erreichen. Zu den verschiedenen Methoden der Geburtseinleitung gehören insbesondere die Verabreichung von Oxytocin oder Prostaglandinen, die Amniotomie, und mechanische Methoden der Zervixdilatation. Der Erfolg der Geburtseinleitung ist vorab abhängig von der Geburtsbereitschaft des Uterus und von der verwendeten Methode. Bei sehr reifer

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11

Mitchell, MD, RJ Romero, SS Edwin, and MS Trautman. "Prostaglandins and parturition." Reproduction, Fertility and Development 7, no. 3 (1995): 623. http://dx.doi.org/10.1071/rd9950623.

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It seems likely that prostaglandins play a significant part in the mechanisms of parturition both at term and preterm. Concentrations of prostaglandins are increased in the blood, urine and amniotic fluid during labour. There are differences in the concentrations of prostaglandins in amniotic fluid from the forebag and hindbag. Nevertheless, if liquor is sampled only from the hindbag a highly significant increase in prostaglandin concentrations occurs throughout labour. Furthermore, we now have evidence that prostaglandin concentrations in amniotic fluid increase before the onset of labour. Pr

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12

Watson, John, and Siew Yeam Chuah. "Technique for the primary culture of human breast cancer cells and measurement of their prostaglandin secretion." Clinical Science 83, no. 3 (1992): 347–52. http://dx.doi.org/10.1042/cs0830347.

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1. A method is described for the primary culture of human breast tumour cells on feeder layers of the STO mouse embryo fibroblast cell line. 2. The secretion of the prostaglandins E2 and F2α from the cells was measured and the results indicate that the secretion of both prostaglandins was dependent on oestrogen-receptor status, with cells from oestrogen-receptor-positive tumours secreting significantly more prostaglandin than cells from oestrogen-receptor-negative tumours. 3. Postaglandin E2, but not prostaglandin F2α, secretion was also significantly greater from cells of tumours from postmen

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13

Madar, R. John, Tim J. D. Donaldson, and Stewart Hunter. "Prostaglandins in congenital heart disease—potential for confusion." Cardiology in the Young 5, no. 2 (1995): 202–3. http://dx.doi.org/10.1017/s1047951100011859.

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the use of prostaglandians in maintaining the patency of the arterial duct in congenital heart disease is well established. Intravenous1-3 and ora12–4 administration has been used, although for acute use intravenous and possibly intraosseous5 routes are favored. Both prostaglandin E1 (alprostadil—ProstinVR: Upjohn)1,4 and prostaglandin E2 (dinoprostone—Prostin E2: Upjohn)2,3 are used for this purpose, although only prostaglandin E1 is licensed for this indication in the United Kingdom. Prostaglandin E1 costs approximately 8 times more than prostaglandin E2 (£56.96 versus £7.43 per vial).

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14

Sahmay, S., A. Coke, N. Hekim та T. Atasu. "Maternal, Umbilical, Uterine and Amniotic Prostaglandin E and F2α Levels in Labour". Journal of International Medical Research 16, № 4 (1988): 280–85. http://dx.doi.org/10.1177/030006058801600405.

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This paper confirms the important role played by prostaglandins in the induction of uterine contractions and the initiation of human labour, although the exact mechanism of action in labour remains unclear. Seventeen pregnant women at term were studied. Of these nine were in labour and the remainder underwent elective section. Prostaglandin E and F2α levels were measured in maternal, umbilical and uterine plasma and amniotic fluid by radioimmunoassay. Levels of prostaglandin E were generally higher than prostaglandin F2α but they were significantly lower in maternal and uterine plasma. Levels

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15

Scott, I. M., R. H. Fertel, and J. A. Boulant. "Leukocytic pyrogen effects on prostaglandins in hypothalamic tissue slices." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 253, no. 1 (1987): R71—R76. http://dx.doi.org/10.1152/ajpregu.1987.253.1.r71.

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Some studies suggest that leukocytic pyrogen (LP) increase hypothalamic prostaglandins which, in turn, affect hypothalamic thermoregulatory neurons to produce fever. The present study used radioimmunoassays to quantitate the ability of guinea pig hypothalamic tissue slices to produce prostaglandin E2 (PGE2), prostaglandin F2 alpha (PGF2 alpha), 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), and thromboxane B2 (TxB2). Dose- and time-dependent prostaglandin increases occurred when these slices were perfused with LP media. Steady-state levels of tissue release were reached at 0-3 min for 6-ke

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16

Lijnen, P., J. Staessen, R. Fagard, and A. Amery. "Effect of prostaglandin inhibition by indomethacin on plasma active and inactive renin concentration in men." Canadian Journal of Physiology and Pharmacology 69, no. 9 (1991): 1355–59. http://dx.doi.org/10.1139/y91-200.

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The effect of inhibition of prostaglandin synthesis by indomethacin on active renin and on acid-activable inactive renin was studied in nine healthy, sodium-replete men, both at rest and exercise. These volunteers were investigated after pretreatment with placebo or indomethacin, 150 mg daily for 3 days. Indomethacin induced a decrease in active (p = 0.004), total (p < 0.001), and inactive (p = 0.02) renin at rest recumbent on average by 42, 19, and 8%, respectively, and at rest sitting on average by 45, 15, and 3%, respectively. Inhibition of prostaglandins with indomethacin reduced (p &lt

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17

Bandali, Karim S., and Uwe Ackermann. "Are prostaglandins involved in atrial natriuretic peptide mechanisms of cardiovascular control?" Canadian Journal of Physiology and Pharmacology 77, no. 3 (1999): 211–15. http://dx.doi.org/10.1139/y99-004.

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Atrial natriuretic peptide (ANP) can excite cardiac nerve endings and invoke a decrease in arterial blood pressure and a reduction in renal sympathetic nerve activity. Our laboratory has previously demonstrated that this renal depressor reflex was invoked by systemic injection of ANP and not by the direct application of ANP to the epicardium, a major locus for vagal afferents. We now examine whether inhibition of prostaglandin synthesis impairs reflex responses that are normally associated with ANP injections. Renal sympathetic nerve activity, arterial blood pressure, and heart rate were recor

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18

Dongre, Veena, R. C. Dabhade, and A. M. Khurad. "Effect of prostaglandin on reproduction in relation to pituitary gonadal axis in the fish, Cyprinus carpio (L.)." Journal of Applied and Natural Science 4, no. 2 (2012): 192–95. http://dx.doi.org/10.31018/jans.v4i2.247.

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Prostaglandins are a class of fatty acids which are “traditionally” associated with a variety of autocrine and paracrine functions in the vertebrate body. In many fishes, however, F prostaglandins also function as a hormone that stimulates sexual behavior. In the present study, F prostaglandin was used to assess the efficacy on reproductive behavior and spawning in relation to pituitary gonadal axis in the fish, Cyprinus carpio by administering different doses. Early maturity was observed in fish leading to courtship and spawning. The histological study of olfactory lobe, pituitary gland and g

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19

Thore, C. R., M. Nam, and D. Busija. "Phorbol ester-induced prostaglandin production in piglet cortical astroglia." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 267, no. 1 (1994): R34—R37. http://dx.doi.org/10.1152/ajpregu.1994.267.1.r34.

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We examined effects of phorbol 12,13-dibutyrate (PDB), which activates protein kinase C (PKC), on prostaglandin and leukotriene production in piglet cultured glia derived from cerebral cortex and white matter. Levels of prostaglandins were determined using enzyme immunoassay. Baseline levels in media for prostaglandin F2 alpha (PGF2 alpha) were 730 +/- 116 pg/ml and increased to 1,551 +/- 196 pg/ml at 10(-8) M PDB (P < 0.05) and to 2,182 +/- 190 pg/ml at 10(-6) M PDB (P < 0.05) (n = 16). Little or no 6-keto-prostaglandin F1 alpha, prostaglandin E2, or leukotrienes C4/D4 were produced. PG

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20

Hsu, Ho-Wei, Ting-Yi Lin, Yi-Ching Liu, Jwu-Lai Yeh, and Jong-Hau Hsu. "Molecular Mechanisms Underlying Remodeling of Ductus Arteriosus: Looking beyond the Prostaglandin Pathway." International Journal of Molecular Sciences 22, no. 6 (2021): 3238. http://dx.doi.org/10.3390/ijms22063238.

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The ductus arteriosus (DA) is a physiologic vessel crucial for fetal circulation. As a major regulating factor, the prostaglandin pathway has long been the target for DA patency maintenance or closure. However, the adverse effect of prostaglandins and their inhibitors has been a major unsolved clinical problem. Furthermore, a significant portion of patients with patent DA fail to respond to cyclooxygenase inhibitors that target the prostaglandin pathway. These unresponsive medical patients ultimately require surgical intervention and highlight the importance of exploring pathways independent f

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Bedrick, A. D., M. A. Wells, D. L. Ford, and O. Koldovsky. "Intact biliary excretion of gastrically administered prostaglandin F2 alpha in rats: developmental differences." American Journal of Physiology-Gastrointestinal and Liver Physiology 253, no. 6 (1987): G787—G792. http://dx.doi.org/10.1152/ajpgi.1987.253.6.g787.

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Tritium-labeled prostaglandin F2 alpha was administered via orogastric tube to bile duct-cannulated suckling and weanling rats to determine if maturational differences were present in the biliary excretion of prostaglandin F2 alpha and metabolites. Animals were killed 2 h after radioactivity administration. Characterization of radioactivity present in bile revealed age-related differences in biliary prostaglandin F2 alpha excretion. Suckling rats had a greater proportion of radioactivity migrating in chromatographic regions of greater polarity than prostaglandin F2 alpha. Compared with the wea

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22

Asrina, Andi, Arsyad Aryadi, and Nilawati Andi. "Kadar Prostaglandin dan Endorfin pada Remaja dengan Dismenore Primer yang diberi Hidroterapi Hangat dan Dingin." Jurnal Riset Kesehatan Poltekkes Depkes Bandung 12, no. 1 (2020): 115–21. http://dx.doi.org/10.34011/juriskesbdg.v12i1.841.

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This study aims to determine the comparison of prostaglandin and endorphin levels in adolescents with primary dysmenorrhea with and without warm (37-40oC) and cold (18-20oC) hydrotherapy. This quasi-experimental study with a post-test only controls group design was carried out in Islamic Boarding Schools with a sample of 36 young girls divided into 3 groups: 12 teens given warm hydrotherapy, 12 teens given cold hydrotherapy and 12 teens not given intervention (control). Blood plasma is taken after an intervention is given on the first day of menstruation. Examination of prostaglandin and endor

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23

Ajuebor, Maureen N., Anita Singh, and John L. Wallace. "Cyclooxygenase-2-derived prostaglandin D2 is an early anti-inflammatory signal in experimental colitis." American Journal of Physiology-Gastrointestinal and Liver Physiology 279, no. 1 (2000): G238—G244. http://dx.doi.org/10.1152/ajpgi.2000.279.1.g238.

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The ability of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors to exacerbate inflammatory bowel disease suggests that prostaglandins are important anti-inflammatory mediators in this context. Prostaglandin D2 has been suggested to exert anti-inflammatory effects. We investigated the possibility that prostaglandin D2 derived from cyclooxygenase-2 plays an important role in downregulating colonic inflammation in rats. Colitis was induced by intracolonic administration of trinitrobenzene sulfonic acid. At various times thereafter (from 1 h to 7 days), colonic prostaglandin sy

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Mikkelsen, Ulla Ramer, Ida Carøe Helmark, Michael Kjær, and Henning Langberg. "Prostaglandin synthesis can be inhibited locally by infusion of NSAIDS through microdialysis catheters in human skeletal muscle." Journal of Applied Physiology 104, no. 2 (2008): 534–37. http://dx.doi.org/10.1152/japplphysiol.01016.2007.

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Prostaglandins are known to be involved in the regulation of local blood flow within human skeletal muscles during exercise, and the concentration of prostaglandins increases locally and systemically in response to exercise. The systemic release of prostaglandins can be inhibited by oral intake of nonsteroidal anti-inflammatory drugs (NSAIDs). However, to study the local role of prostaglandins, the formation of prostaglandins within the tissue must be controlled. Microdialysis enables determination of local concentrations of water-soluble substances within the tissue. In the present study, the

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Tsang, B. K., M. T. Domingo, J. E. H. Spence, P. R. Garner, D. K. Dudley, and H. Oxorn. "Endometrial prostaglandins and menorrhagia: influence of a prostaglandin synthetase inhibitor in vivo." Canadian Journal of Physiology and Pharmacology 65, no. 10 (1987): 2081–84. http://dx.doi.org/10.1139/y87-326.

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Prostaglandin levels in the human endometrium were determined on day 2 of the menstrual cycle in eumenorrheic subjects and in patients with menorrhagia, dysmenorrhea, or both. Menorrhagic subjects had significantly higher levels of endometrial prostaglandins of the E and F series when compared with eumenorrheics. Prostaglandin E levels were markedly higher than prostaglandin F. In 10 menorrhagic subjects who completed a double-blind clinical study on the effectiveness of mefenamic acid in lowering menstrual blood loss, 9 exhibited statistically significant reduction in endometrial prostaglandi

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Adachi, Hisanobu, Takehiro Suzuki, Michiaki Abe, et al. "Molecular characterization of human and rat organic anion transporter OATP-D." American Journal of Physiology-Renal Physiology 285, no. 6 (2003): F1188—F1197. http://dx.doi.org/10.1152/ajprenal.00402.2002.

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We have isolated and characterized a novel human and rat organic anion transporter subtype, OATP-D. The isolated cDNA from human brain encodes a polypeptide of 710 amino acids ( Mr 76,534) with 12 predicted transmembrane domains. The rat clone encodes 710 amino acids ( Mr 76,821) with 97.6% amino acid sequence homology with human OATP-D. Human and rat OATP-D have moderate amino acid sequence homology with LST-1/rlst-1, the rat oatp family, the prostaglandin transporter, and moat1/MOAT1/KIAA0880/OATP-B. Phylogenetic tree analysis revealed that OATP-D is branched in a different position from all

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Beierwaltes, W. H. "Prostaglandin independence of kinin-stimulated renin release." American Journal of Physiology-Renal Physiology 252, no. 5 (1987): F794—F799. http://dx.doi.org/10.1152/ajprenal.1987.252.5.f794.

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Bradykinin can increase prostaglandin synthesis and also stimulate renin release in vitro. Because prostaglandins also stimulate renin, studies were performed to determine whether bradykinin stimulation of renin is a function of prostaglandin synthesis. Isolated glomeruli with attendant arteriolar attachments were harvested from rat kidneys and superfused. The effluent was analyzed for renin, prostaglandins E2 and I2 (6-keto-PGF1 alpha). Bradykinin (10(-5) M) increased renin by 50% with a concomitant increase in prostacyclin (PGI2) but not in prostaglandin E2 (PGE2). The cyclooxygenase inhibit

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Gibb, William, and Jean-Claude Lavoie. "Effects of glucocorticoids on prostaglandin formation by human amnion." Canadian Journal of Physiology and Pharmacology 68, no. 6 (1990): 671–76. http://dx.doi.org/10.1139/y90-101.

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The human amnion may be an important source of prostaglandins involved in the onset of human labor and therefore it is important to define the factors that regulate their formation in this tissue. In the present study we demonstrate that glucocorticoids inhibit prostaglandin production by freshly isolated amnion cells. The inhibitory action of the glucocorticoids, however, changes to a stimulatory action when the cells are maintained in primary culture for a few days. For both inhibition and stimulation, concentrations of 10−8 M dexamethasone or greater were required to give significant effect

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Hartuti, Noviyani, and Asyima Asyima. "Hubungan prostaglandin terhadap kejadian premenstrual syndrome (PMS) pada remaja putri." Holistik Jurnal Kesehatan 15, no. 4 (2022): 713–19. http://dx.doi.org/10.33024/hjk.v15i4.5307.

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Background: Young women and middle-aged women during the luteal phase of the menstrual cycle will experience emotional and physical problems called premenstrual syndrome (PMS).Purpose: To determine the relationship of prostaglandins to the incidence of premenstrual syndrome in young women at the Pelamonia Midwifery Academy.Method: A Cross-Sectional Study with a population was the student of nursing academy Pelamonia Makassar. The sampling technique used a total sampling technique with a sample of 50 respondents. The research instrument used a daily note sheet (LCH), questionnaire data collecti

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Kulsum, Syeda Ummay, Sabera Khatun, and SM Shahnawaz Bin Tabib. "Use of Misoprostol in Pregnancy- A Review Article." Medicine Today 22, no. 2 (2012): 94–98. http://dx.doi.org/10.3329/medtoday.v22i2.12443.

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Prostaglandins are the pharmacological agents used for induction of labour and augmentation of labour. Prostaglandin E2 gel is used for cervical ripening and induction of labour. These are however, costly and need to be stored in a refrigerator at a temperature of 2 - 8°C, half life 18 months. The Tablet form of prostaglandin E2 is not available in Bangladesh. Misoprostol, a synthetic prostaglandin (PG) E1 analogue is used orally for the treatment of gastric and duodenal ulcer and used as a cytoprotective agent. It was first used for labour induction in 1987. Prostaglandin can be used in sever

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Kutyrev, Olennikov, Kaschenko, and Mazur. "DYNAMICS OF SECRETION OF PROSTAGLANDINS E2 AND D2 WITH DIBOTHRIOCHEPHALLUS DENDRITICUS (CESTODA) PLEROCERCOIDS IN RESPONSE TO EXPOSURE OF BLOOD SERUM OF BAIKAL CISCO, THE HOST." THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL, no. 21 (May 29, 2020): 180–86. http://dx.doi.org/10.31016/978-5-9902341-5-4.2020.21.180-186.

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Parasites regulate host immune response via secretion of soluble mediators which interact in a certain way with cells and molecules of the immune system. The aim of the study was to determine changes of prostaglandins E2 и D2 content in Dibothriochephallus dendriticus plerocercoids and also in the incubation media during incubation of tapeworms with addition of blood serum from the intermediate host – Baikal cisco. D. dendriticus plerocercoids were retrieved from the host body cavity, ashed in the physiological solution and placed in incubation media. Microcolumn high-performance liquid chroma

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Zorzano, A., T. W. Balon, J. A. Jakubowski, M. N. Goodman, D. Deykin, and N. B. Ruderman. "Effects of insulin and prior exercise on prostaglandin release from perfused rat muscle Evidence that prostaglandins do not mediate changes in glucose uptake." Biochemical Journal 240, no. 2 (1986): 437–43. http://dx.doi.org/10.1042/bj2400437.

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Prostaglandin generation and its inter-relation to the metabolic effects of insulin and prior exercise were examined in perfused muscle of fed rats. During a 60 min perfusion of the rat hindquarter, a substantial release of the prostaglandins PGF2 alpha, PGE2 and 6-oxoPGF1 alpha was observed. Blood cells present in the perfusate released these substances in negligible amounts indicating the prostaglandins were produced by the hindquarter. Addition of insulin to the perfusate increased both glucose uptake and the generation of PGE2 and 6-oxoPGF1 alpha. At 30 min after intense treadmill exercise

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Ortega-Moreno, J. "Influence of prostaglandins E2 and F2α on passage pressure across the uterotubal junction and isthmus in the rat". Laboratory Animals 29, № 3 (1995): 327–34. http://dx.doi.org/10.1258/002367795781088333.

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The influence of prostaglandins E2 and F2α on passage pressure across the uterotubal junction (UTJ) and isthmus were studied in rats that were either in the pro-oestrus, oestrus, metoestrus or dioestrus phases. Effects of these prostaglandins were also investigated in rats that had been either ovariectomized and treated with oestradiol or medroxiprogesterone acetate, or only ovariectomized. In each rat, the left UTJ was surgically resected and the isthmus anastomosed to the uterine horn, whereas the right UTJ was left untouched. The passage pressures across the left isthmus and the right UTJ w

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Deenarn, Pacharawan, Punsa Tobwor, Vanicha Vichai, et al. "Polychaete consumption increased prostaglandin biosynthesis in female Penaeus monodon." Reproduction 160, no. 6 (2020): 873–85. http://dx.doi.org/10.1530/rep-20-0217.

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The polychaete Perinereis nuntia is preferred over commercial feed pellets for boosting ovarian maturation of the female black tiger shrimp Penaeus monodon. High levels of prostaglandins in polychaetes are believed to enhance shrimp ovarian development. However, the impact of polychaete feeding on shrimp prostaglandin biosynthesis and fatty acid regulatory pathways have yet to be investigated. As polychaetes contain higher levels of arachidonic acid (ARA), eicosapentaenoic acid (EPA), prostaglandin E2 (PGE2) and prostaglandin F2α (PGF2α) than feed pellets, we examined the effects of polychaete

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Curtis, Glenn H., D. Grant Gall, John L. Wallace, and Wallace K. MacNaughton. "Intraluminal pH modulates gastric prostaglandin synthesis." Canadian Journal of Physiology and Pharmacology 73, no. 1 (1995): 130–34. http://dx.doi.org/10.1139/y95-018.

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Prostaglandins play an important role in modulating gastric mucosal integrity and in regulating gastric acid secretion, but little is known regarding regulation of prostaglandin synthesis by the stomach. We have therefore examined the effects of changes in gastric intraluminal pH on the capacity of gastric tissue to synthesize prostaglandin E2. Oral administration of solutions with a pH of 8.3 or 10 markedly reduced the capacity of the gastric tissue to synthesize prostaglandin E2, but did not affect synthesis of leukotriene B4. This phenomenon was observed in three strains of rats. Administra

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Srivastava, R. C., A. Tandon, A. N. Nagappa та R. K. Sharma. "Liquid membrane phenomena in prostaglandins: Studies on prostaglandin E1 and prostaglandin F2α". Journal of Colloid and Interface Science 117, № 2 (1987): 375–83. http://dx.doi.org/10.1016/0021-9797(87)90396-1.

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Goetz, F. W. "Compartmentalization of prostaglandin synthesis within the fish ovary." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 260, no. 5 (1991): R862—R865. http://dx.doi.org/10.1152/ajpregu.1991.260.5.r862.

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Numerous studies have shown that the follicle walls surrounding mature vertebrate oocytes are capable of producing primary prostaglandins. However, very few studies have looked at the prostaglandin synthetic potential of other ovarian tissue components. In brook trout (Salvelinus fontinalis) and goldfish (Carassius auratus), mature follicle walls can produce prostaglandins E and F (PGE and PGF, respectively); however, it is apparent that several other tissues within the fish ovary also produce specific primary PGs. Incubation of stroma or connective tissue from brook trout and goldfish ovaries

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Laurent, Fabrice, Martin F. Kagnoff, Tor C. Savidge, Muriel Naciri та Lars Eckmann. "Human Intestinal Epithelial Cells Respond toCryptosporidium parvum Infection with Increased Prostaglandin H Synthase 2 Expression and Prostaglandin E2and F2α Production". Infection and Immunity 66, № 4 (1998): 1787–90. http://dx.doi.org/10.1128/iai.66.4.1787-1790.1998.

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ABSTRACT Cryptosporidium parvum is an important cause of diarrhea in humans and several animal species. Prostaglandins play a central role in regulating intestinal fluid secretion in animal models of cryptosporidiosis, but their cellular sources and mechanisms of induction are unclear. Here, we show that C. parvuminfection directly activates prostaglandin H synthase 2 expression and prostaglandin E2 and F2α production in human intestinal epithelial cells.

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Rayhel, E. J., D. A. Prentice, P. S. Tabor та ін. "Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-β". Biochemical Journal 253, № 1 (1988): 295–98. http://dx.doi.org/10.1042/bj2530295.

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Transforming growth factor-beta (TGF-beta) inhibits proliferation of Nb2 cells, a rat T lymphoma, in response to lactogens and interleukin-2. Prostaglandins may play an important role in the pathway through which TGF-beta exerts its inhibitory actions, because prostaglandin E2 also inhibits proliferation of Nb2 cells, and indomethacin, an inhibitor of prostaglandin synthesis, reverses the inhibitory effects of TGF-beta on Nb2 cell proliferation.

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Kunapuli, S. P., G. Fen Mao, M. Bastepe, et al. "Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells." Biochemical Journal 298, no. 2 (1994): 263–67. http://dx.doi.org/10.1042/bj2980263.

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Prostaglandins inhibit platelet activation by stimulating intracellular cyclic AMP formation. We have postulated that intracellular cyclic AMP levels in platelets are buffered by a distinct prostaglandin receptor that mediates inhibition of cyclic AMP formation. In order to provide evidence for the model, we have cloned the cDNA coding for a prostaglandin receptor EP3 subtype, which is coupled to inhibition of adenylate cyclase, from the megakaryocytic cell line human erythroleukaemia (HEL) cells. A PCR-generated hybridization probe, produced using primers based on the sequence of the mouse pr

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Braun, Marina, and K. Schrör. "Pharmakologische Grundlagen der Prostaglandin-Therapie." Hämostaseologie 13, no. 02 (1993): 53–57. http://dx.doi.org/10.1055/s-0038-1655212.

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ZusammenfassungVasodilatierende Prostaglandine werden zur Therapie fortgeschrittener Stadien der peripheren arteriellen Verschlußkrankheit und der Thrombangiitis obliterans eingesetzt. Der klinische Nutzen liegt vor allem in der therapeutischen Anwendung in Fällen, wo chirurgische Maßnahmen nicht angezeigt bzw. erfolglos geblieben sind. Eine Reihe von klinischen Studien belegt die klinische Wirksamkeit der systemischen Anwendung von Prostaglandin E1 und lloprost. Die pharmakologischen Wirkungen dieser Substanzen betreffen nicht nur den Vasotonus, sondern auch Zellen des strömenden Blutes sowie

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Cui, Jian, Patrick McQuillan, Afsana Momen, et al. "The role of the cyclooxygenase products in evoking sympathetic activation in exercise." American Journal of Physiology-Heart and Circulatory Physiology 293, no. 3 (2007): H1861—H1868. http://dx.doi.org/10.1152/ajpheart.00258.2007.

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Animal studies suggest that prostaglandins in skeletal muscles stimulate afferents and contribute to the exercise pressor reflex. However, human data regarding a role for prostaglandins in this reflex are varied, in part because of systemic effects of pharmacological agents used to block prostaglandin synthesis. We hypothesized that local blockade of prostaglandin synthesis in exercising muscles could attenuate muscle sympathetic nerve activity (MSNA) responses to fatiguing exercise. Blood pressure (Finapres), heart rate, and MSNA (microneurography) were assessed in 12 young healthy subjects d

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Smith, D. M., and P. H. Sugden. "Effects of pressure overload and insulin on protein turnover in the perfused rat heart. Prostaglandins are not involved although their synthesis is stimulated by insulin." Biochemical Journal 243, no. 2 (1987): 473–79. http://dx.doi.org/10.1042/bj2430473.

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A modified anterogradely perfused rat heart preparation is described in which all the cardiac output passes through the coronary circulation. Such a preparation develops hypertensive aortic pressures. Hypertensive aortic pressures or insulin stimulate the rate of cardiac protein synthesis and inhibit the rate of protein degradation. Aortic pressure and insulin may be important in the regulation of cardiac nitrogen balance in vivo. By abolishing cardiac prostaglandin synthesis with 4-biphenylacetate, we were able to investigate the possible involvement of prostaglandins in the modulation of pro

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Wood, Eilidh M., Kylie K. Hornaday, Matthew Newton, Melinda Wang, Stephen L. Wood, and Donna M. Slater. "Urinary prostaglandin metabolites as biomarkers for human labour: Insights into future predictors." PLOS One 20, no. 7 (2025): e0315484. https://doi.org/10.1371/journal.pone.0315484.

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Prostaglandins and other related molecules in the eicosanoid family have long been implicated in the process of both term and preterm labour. Although, exactly which eicosanoids are involved and whether they have utility as biomarkers for labour, remains to be shown. The objective of this study was to determine whether urinary prostaglandins and related molecules a) change with labour and/or cervical changes, at term and preterm, and/or b) are associated with timing of delivery in individuals with threatened preterm labour. Pregnant individuals were recruited into the following groups: n = 32

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Fuchs, Michaela A. A., Julia Schrankl, Christina Leupold, Charlotte Wagner, Armin Kurtz, and Katharina A. E. Broeker. "Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice." American Journal of Physiology-Renal Physiology 322, no. 3 (2022): F295—F307. http://dx.doi.org/10.1152/ajprenal.00414.2021.

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Cyclooxygenase-2 (Cox-2) produces prostaglandins that are essential for normal renal development. It is unclear in which cells Cox-2 and the receptors for prostaglandin E2 (EP receptors) are expressed during late nephrogenesis. This study identified the expression sites for EP subtypes and Cox-2 in neonatal mouse kidneys. Furthermore, it shows that stromal progenitor cells may require intact prostaglandin E2 signaling through EP2 and EP4 receptors for normal renal development.

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Bergelson, L. D. "The interaction of prostaglandins with human serum lipoproteins." Bioscience Reports 9, no. 1 (1989): 27–40. http://dx.doi.org/10.1007/bf01117509.

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Using high density and low density lipoproteins (HDL and LDL) labeled with fluorescent analogues of phosphatidylcholine or sphingomyelin it was found that low amounts (10−12 M) of prostaglandins E1 and F2α induced different structural rearrangements of the lipoprotein surface, whereas prostaglandins E2 and F1α had no effect. The effects of prostaglandin E1 on HDL were largely paralled by those of this prostaglandin on synthetic recombinants prepared from pure apolipoprotein A1, phospholipids and cholesterol and were demonstrated to be caused by prostaglandin-apolipoprotein interaction. The int

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Alojayli, Anas, and Rahim Haloob. "Success rate of repeated cycles of induction in labour in a UK clinical setting: A cohort study." F1000Research 12 (March 31, 2023): 356. http://dx.doi.org/10.12688/f1000research.128241.1.

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Background: Births are increasingly started artificially using medications such as prostaglandin, oxytocin, or other mechanical methods, a process known as induction of labour (IOL). The aim of the study was to identify the success rate of a repeat cycle of induction of labour (IOL) with prostaglandins, and any association between smoking and patient response to prostaglandin. Methods: This was a retrospective cohort study set in Basildon and Thurrock University Hospital, UK. IOL data from patients were collected between 1 January 2021 and 30 March 2021. Data were retrieved from hospital recor

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Lang, Sally A., and Michael B. Maron. "Role of Prostaglandins in Blood-Induced Vasoconstriction of Canine Cerebral Arteries." Journal of Cerebral Blood Flow & Metabolism 8, no. 1 (1988): 109–15. http://dx.doi.org/10.1038/jcbfm.1988.14.

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We tested the hypothesis that the vasoconstriction produced by the application of blood to the adventitial surfaces of the vessels of an isolated perfused canine circle of Willis preparation was mediated by products of prostaglandin metabolism. In this preparation (perfused at constant flow and outflow pressure), topical application of blood produced an average 16.6 ± 1.8 (SE) mm Hg increase in inflow pressure. This response could be prevented with four structurally dissimilar cyclooxygenase inhibitors (aspirin, indomethacin, ibuprofen, and meclofenamate), suggesting that the blood-induced inc

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Tanase, Constantin I., Lucia Pintilie та Elena Mihai. "A Molecular Docking of New 9β-Halogenated Prostaglandin Analogues". Proceedings 41, № 1 (2019): 21. http://dx.doi.org/10.3390/ecsoc-23-06504.

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Prostaglandins (PGs) with cytoprotective activity were studied for a long time, and a few PGE1 and PGE2 stable analogues were promoted as drugs: arbaprostil, enprostil, misoprostol, and rioptostol. Similarly, nocloprost, a 9β-chlorine prostaglandin analogue, and many 9β- and 11β-substituted prostaglandins were synthesized and studied for their biological activity. We previously synthesized new 9β-halogenated prostaglandins with an ester group at the carbon atom 6 (PGs numbering) by the reaction of a δ-lactone intermediate with diols in acid catalysis. These compounds were used in the current m

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Tanase, Constantin I., Lucia Pintilie та Elena Mihai. "A Molecular Docking of New 9β-Halogenated Prostaglandin Analogs with an Ester Group at C-6 Atom of the α-Side Chain". Revista de Chimie 71, № 4 (2020): 101–10. http://dx.doi.org/10.37358/rc.20.4.8048.

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Prostaglandins with cytoprotective activity were studied for a long time and a few PGE1 and PGE2 stable analogs were promoted as drugs: arbaprostil, enprostil, misoprostol and rioptostol. Nocloprost, a 9β-chlorine prostaglandin analog, has been also promoted as a cytoprotective drug; the succes with this compound stimulated the reserches, and many 9β- or 11β-substituted prostaglandins were synthesized and studied for their biological activity. In the same dirrection we previously synthesized new 9β-halogenated prostaglandins having also an ester group at the carbon atom 6. These compounds were

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