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Dissertations / Theses on the topic 'Prostate cancer and multiple myeloma'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Harrison, Simon James. "Immunotherapy in multiple myeloma." Thesis, University of Glasgow, 2005. http://theses.gla.ac.uk/1054/.

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The BDCA antibodies allowed reliable measurement of dendritic cell (DC) subsets and B cell numbers in the blood of normal subjects, and patients with MM throughout the disease course. The numbers of blood myeloid DC (BmDC) and blood plasmacytoid DC (BpDC) are low throughout the course of the disease, and only improve for a short period of time following autologous HSCT. Thalidomide therapy of patients with relapsed disease was associated with an increase in BmDC1 and BpDC numbers. Monocytes, mobilised at the time of stem cell collection, were used to produce mature DC (matDC) from MM patients

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2

Dimberg, Lina. "Apoptosis Regulation in Multiple Myeloma." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7099.

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3

Mhadgut, Hemendra M. D., Alay Mansurov, Rabia Zafar, and Koyamangalath Krishnan. "Liver Mass: An Unusual Presentation of Multiple Myeloma." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/22.

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Multiple myeloma is characterized by proliferation of plasma cells in the bone marrow, producing monoclonal immunoglobulin. It accounts for 17% of hematologic malignancies in the US. Diagnosis is often suspected in the setting of bone lytic lesions, anemia, hypercalcemia or renal failure. Rarely, multiple myeloma can present with soft tissue involvement which can be difficult to diagnose. Below we present one such presentation. Our patient is a 53-year-old who was initially diagnosed with multiple myeloma six years back when he presented to hospital with back and right leg pain. On admission h

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4

Cook, Gordon. "Immune regulation in multiple myeloma : the host-tumour conflict." Thesis, University of Glasgow, 2000. http://theses.gla.ac.uk/6140/.

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The data presented in this thesis demonstrates that the malignant plasma cells of multiple myeloma are capable of suppressing the activation of T lymphocytes. The myeloma cells prevent activation of T cells from healthy donors by allo-antigen, mitogen and IL-2, mediated by the production of soluble, immuno-suppressive factor. This factor was responsible for inducing cell cycle arrest and failure of the T cells to progress into the autocrine IL-2 autocrine pathway, which is of critical importance in the activation of T cells. To further investigate this interaction an in vitro model system was

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5

INTERNATI, M. CHIRIVA. "PRECLINICAL TESTING OF GALECTIN-3C FOR MULTIPLE MYELOMA." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/168390.

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The American Cancer Society expects that there will be more than 20,000 new cases of multiple myeloma (MM) in the US in 2011 and despite the new treatments now available, the median survival rate is only 5 years. Galectin-3C (Gal-3C) is a human lectin involved in cellular processes including cellular differentiation, apoptosis, neoplastic transformation, and metastasis. Gal-3C contains the carbohydrate recognition domain (CRD) of galectin-3 and is thought to act as a dominant negative inhibitor of galectin-3-mediated cross-linking. Gal-3C is a proprietary truncated, inhibitory form of galec

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6

Faiman, Beth Marie. "Peripheral Neuropathy and Diarrhea Symptoms in Multiple Myeloma." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1417619492.

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7

Machin, Reinaldo Franqui. "Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6104.

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Multiple Myeloma (MM) is an incurable plasma cell malignancy and, although novel treatment regimes in the past decade have improved patient outcome, long-term treatment leads to relapse and refractory disease. The centrosomal kinase NEK2 is found overexpressed in MM and promotes chromosomal instability, drug resistance and increased proliferation. Although much research shows NEK2 having a detrimental effect in cancer, much of its mechanisms of overexpression and drug resistance has not been studied in detail. In this work we expand our understanding of NEK2 in MM. Using Tandem Affinity Purifi

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8

Zabalo, Joaquin. "A Mathematical Model Describing the Early Development of Multiple Myeloma." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/366.

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Multiple myeloma is a malignant bone marrow plasma cell tumor which is responsible for approximately 12,000 deaths per year in the United States and two percent of all cancer deaths. It is recognized clinically by the presence of more than ten percent bone marrow plasma cells, the detection of a monoclonal protein (M-protein), anemia, hypercalcemia, renal insufficiency, and lytic bone lesions. The disease is usually preceded by a premalignant tumor called monoclonal gammopathy of undetermined significance (MGUS), which is present in one percent of adults over the age of fifty, three percent ov

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9

Kendrick, Felicity. "Modelling immunoglobulin metabolism and its effect on prognostic utility in multiple myeloma." Thesis, University of Warwick, 2018. http://wrap.warwick.ac.uk/104030/.

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Multiple myeloma is a cancer of plasma cells. In multiple myeloma, a clone of plasma cells in the bone marrow secretes a unique, monoclonal immunoglobulin (Ig), whose biological properties depend on its type and structure. The monoclonal Ig offers a convenient opportunity for clinicians to monitor the response of the tumour to therapy via the secreted protein, which is readily quantified in a blood sample. Responses to treatment are assigned based on the percentage reduction in monoclonal Ig; however, response criteria do not take into account the different metabolic half-lives of the proteins

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10

Drake, Mary. "Characterisation of mononuclear cells in peripheral blood stem cell harvests." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287206.

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11

Dorjsuren, Delgerzul, Holly Abigail Adams, Dawnna Elisabeth Metcalfe, and Victoria E. Palau. "Finding Novel and Synergistic Cytotoxic Agents for the Treatment of Multiple Myeloma." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/180.

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Multiple Myeloma is cancer of plasma cells and is known to be highly invasive. Multiple Myeloma makes up 1% of cancer diagnosis in western countries and affects men more predominantly than women. The American Cancer Association estimates that 32,110 new cases will be diagnosed in the United States in 2019. Lenalidomide is one of the main therapies used for multiple myeloma patients, but it has toxic side effects such as thrombocytopenia, neutropenia, and anemia. The purpose of the study is to investigate new cytotoxic agents for the treatment of multiple myeloma. In addition to lenalidomide al

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12

Abdalla, Amir Osman. "Immunological and clinical long-term effects of idiotype vaccination in multiple myeloma patients /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-114-2/.

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13

Corrias, Maria Elena. "A statistical mechanics approach to cancer dynamics: a model for multiple myeloma bone disease." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/18021/.

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L’utilizzo di modelli matematici sta assumendo un ruolo sempre più centrale nella ricerca oncologica. La complessità del cancro ha stimolato gruppi di ricerca interdisciplinare nello sviluppo di modelli quantitativi per rispondere alle numerose domande aperte che riguardano l’insorgenza, la progressione, la diagnosi, la risposta al trattamento terapeutico e l’acquisizione della resistenza ai farmaci dei tumori. La varietà di approcci matematico-fisici ben si adatta allo studio di una materia così eterogenea. In questo lavoro presentiamo innanzitutto gli aspetti biologico-clinici che caratteriz

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14

Stephens, Moira. "Living on: A qualitative study of the experience of living with multiple myeloma." Thesis, The University of Sydney, 2012. http://hdl.handle.net/2123/8859.

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This thesis aims to provide a rich, empirically grounded understanding of what it is like to live with myeloma after the first relapse, in ‘the era of novel agents’. This was achieved by exploring the experience of both the person with myeloma and that of their primary support person though an analysis of their narratives. Consistent with the principles of qualitative enquiry, this study aimed to produce findings that were descriptive, exploratory and explanatory in nature. Qualitative methods were used, involving an inductively-driven analysis of a series of in-depth interviews conducted at s

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15

Jacobson, Timothy. "A Trans-Dimensional View of Drug Resistance Evolution in Multiple Myeloma Patients." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6099.

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Multiple Myeloma (MM) is a treatable, yet incurable, malignancy of bone marrowplasma cells. This cancer affects many patients and many succumb to relapse of tumor burden despite a large number of available chemotherapeutic agents developed for therapy. This is because MM tumors are heterogeneous and receive protection from therapeutic agents by the microenvironment and other mechanisms including homologous MM-MM aggregation. Therefore, therapy failure and frequent patient relapse is due to the evolution of drug resistance, not a lack of available drugs. To analyze and understand this problem,

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16

Turtle, Cameron J. "The CMRF-56+ blood dendritic cell preparation as a vehicle for multiple myeloma immunotherapy /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18657.pdf.

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17

Goodyear, Oliver Charles. "A study of cancer-germline antigen specific T cell responses in patients with multiple myeloma." Thesis, University of Birmingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433641.

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18

Yeung, Ka Yu. "The role of mitochondrial DNA in the tumor biology of glioblastoma multiforme and multiple myeloma." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/62061/.

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Cancer cells preferentially metabolise glucose via aerobic glycolysis (the Warburg effect), which is less energy efficient in teens of ATP production compared to oxidative phosphorylation (OXPHOS). Mitochondrial DNA (mtDNA) encodes proteins of the electron transfer chain and is crucial for functional OXPHOS. MtDNA exists as multiple copies in cells and, often in cancer, there is co-existence of mutant and wild-type mtDNA. There is evidence for mitochondria to contribute towards the tumor biology of multiple myeloma (MM) and glioblastoma multiforme (GBM). The mtDNA from both these cancer types

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19

von, Below Catrin. "PET and MRI of Prostate Cancer." Doctoral thesis, Uppsala universitet, Radiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300940.

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Prostate cancer (PCa) is the most common non-skin malignancy of men in developed countries. In spite of treatment with curative intent up to 30-40% of patients have disease recurrence after treatment, resulting from any combination of lymphatic, hematogenous, or contiguous local spread. The concept of early detection of PCa offer benefits in terms of reduced mortality, but at the cost of over-diagnosis and overtreatment of indolent disease. This is largely due to the random nature of conventional biopsies, with a risk of missing significant cancer and randomly hitting indolent disease. In the

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20

Bagratuni, Tina. "Modulation of endoplasmic reticulum stress as a cancer therapeutic strategy using multiple myeloma as a model." Thesis, Institute of Cancer Research (University Of London), 2010. http://publications.icr.ac.uk/10367/.

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The presence of correctly folded nascent immunoglobulin within the endoplasmic reticulum (ER) provides an effective checkpoint for plasma cell development. A signalling pathway called the unfolded protein response (UPR) allows cells to handle the proper folding of proteins and ensures cell survival. The transcription factor XBP1, a central control point in mediating plasma cell development is also a major regulator of the UPR providing a link between the UPR and plasma cell differentiation. My hypothesis was that inhibition of the UPR and the ER stress pathways will provide a unique differenti

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21

Adesanya, M. A. "Thrombin generation, tissue factor microvesicles and the endothelium in multiple myeloma and pancreatic cancer during treatment." Thesis, University of York, 2018. http://etheses.whiterose.ac.uk/22051/.

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Cancer and its anti-neoplastic treatment are frequently complicated by venous thromboembolism (VTE) occurrence. Multiple myeloma (MM), a haematological malignancy and Pancreatic cancer (PC), a solid tumour are two common malignancies with similarly high VTE incidence, which worsens during treatment. Thrombin production is a key step in the pathologic evolution of VTE and may play an important role in determining VTE risk in cancer patients. The calibrated automated thrombography (CAT) assay is emerging as a reliable tool for real time estimation of thrombin generation (TG) potential, and there

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22

Lee, Min Jae. "THE DEVELOPMENT OF NOVEL PROTEASOME INHIBITORS FOR THE TREATMENT OF MULTIPLE MYELOMA AND ALZHEIMER’S DISEASE." UKnowledge, 2019. https://uknowledge.uky.edu/pharmacy_etds/99.

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Over a decade, proteasome inhibitors (PIs), bortezomib, carfilzomib (Cfz) and ixazomib, have contributed to a significant improvement in the overall survival for multiple myeloma (MM) patients. However, the response rate of PI was fairly low, leaving a huge gap in MM patient care. Given this, mechanistic understanding of PI resistance is crucial towards developing new therapeutic strategies for refractory/relapsed MM patients. In this dissertation work, we found H727 human bronchial carcinoid cells are inherently resistant to Cfz, yet susceptible to other PIs and inhibitors targeting upstream

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23

Issa, Mark E., E. M. K. Wijeratne, A. A. L. Gunatilaka, and Muriel Cuendet. "Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells." FRONTIERS MEDIA SA, 2017. http://hdl.handle.net/10150/625811.

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In spite of recent therapeutic advances, multiple myeloma (MM) remains a malignancy with very low curability. This has been partly attributed to the existence of a drug-resistant subpopulation known as cancer stem cells (CSCs). MM-CSCs are equipped with the necessary tools that render them highly resistant to virtually all conventional therapies. In this study, the growth inhibitory effects of withanolide D (WND), a steroidal lactone isolated from Withania somnifera, on drug-sensitive tumoral plasma cells and drug-resistant MM cells have been investigated. In MTT/XTT assays, WND exhibited simi

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24

Sanchez, Herrero Alvaro. "Tissue engineering of an orthotopic humanised bone-organ as a platform for preclinical multiple myeloma research." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/203046/1/Alvaro_Sanchez%20Herrero_Thesis.pdf.

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This Thesis presents the first steps of the development of a humanized and patient-specific mouse model of multiple myeloma (MM). Novel therapeutic approaches are getting increasingly complex and relevant pre-clinical drug testing is becoming a great challenge. The mouse model presented here features a humanized bone marrow compartment with a humanized bone shell that is able to engraft MM cells and patient-derived hematopoietic stem cells, mimicking myeloma bone disease serving as a unique platform for MM drug testing and discovery.

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25

Lajmi, Nesrine [Verfasser], and Walter [Akademischer Betreuer] Fiedler. "The biological function of Cancer-testis antigen MAGE-C2/CT10 in Multiple Myeloma / Nesrine Lajmi. Betreuer: Walter Fiedler." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1101695935/34.

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26

Lajmi, Nesrine Verfasser], and Walter [Akademischer Betreuer] [Fiedler. "The biological function of Cancer-testis antigen MAGE-C2/CT10 in Multiple Myeloma / Nesrine Lajmi. Betreuer: Walter Fiedler." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1101695935/34.

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27

Maharaj, Lenushka. "Use of in vitro primary culture models to investigate the activity of standard and novel therapies in haematological malignancies." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8532.

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Despite improved treatments for Non-Hodgkin’s Lymphoma (NHL) and Multiple Myeloma (MM), most patients eventually relapse and these diseases remain largely incurable. This has precipitated recent research into more clinically relevant in vitro models to enable development of more effective therapies. We have validated and standardised two in vitro primary culture models using tumour samples derived from patients with NHL, Chronic Lymphocytic Leukaemia (CLL) and MM. Several novel findings have been demonstrated. In vitro sensitivity of primary NHL cells cocultured in a CD40L model predicted clin

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28

Hewson, Emily. "Enabling Real-Time Adaptive Radiotherapy for Multiple Targets." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27841.

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Treating cancer safely and effectively using radiotherapy requires accurate targeting of the tumour. However, internal motion of the tumour due to physiological activity compromises the accuracy of radiotherapy treatment. Managing motion during radiotherapy is further complicated for patients with advanced cancer or oligometastases, where multiple targets can undergo large, independent motion. Prior to this thesis no solution existed to adapt to the motion of independent targets in real time. The aim of this thesis was to develop the first real-time multi-target tracking method. The first two

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29

Rodrigues, Margret S. Tong Alex W. "Growth inhibition of human multiple myeloma cells by a conditional-replicative, oncolytic adenovirus armed with the CD154 (CD40-ligand) transgene." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/5016.

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30

Zammit, Carmen. "The art of healing : A journey through cancer : Implications for art therapy." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 1999. https://ro.ecu.edu.au/theses/1224.

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This thesis is designed to investigate how art assisted in the healing process of a person suffering from a life threatening illness. The research method used is a clinical case study. This study is a form of evaluative research, a systematic data-based inquiry concerning the participant's engagement with art in her healing process, a process which unfolds as being both life affirming and spiritually enriching. This case study takes a qualitative approach, with its emphasis on the participant's own account of her behaviour. The participant is a fifty-three year old woman, a psychiatrist and ps

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31

Casadei, Francesco. "Statistical analysis of genetic and epigenetic features in cancer cells." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/24388/.

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Cancer is one of the leading causes of death in almost every country and, in 2020, 19.3 million new cases and 10 million cancer deaths in the world have been estimated by WHO. The onset of a tumor is often accompanied with a set of genetic and epigenetic alterations, whose understanding can have both diagnostic role and prognostic power for targeted treatments. The spread of NGS platforms, which allow to sequence an entire human genome in a short time and relatively low cost, and the use of statistical methods that help in dealing with such huge amount of data and in finding hidden relationshi

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32

Rudd, JoAnn. "An EM algorithm for mixed-type multiple outcome regressions with applications to a prostate cancer study." College Park, Md.: University of Maryland, 2008. http://hdl.handle.net/1903/8511.

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Thesis (M.A.) -- University of Maryland, College Park, 2008.<br>Thesis research directed by: Dept. of Mathematics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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33

Luo, Qingwei. "“Unknown” prostate cancer stage at diagnosis in a population-based cancer registry: impact on epidemiological studies and use of multiple imputation." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/19948.

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Routinely collected population-based cancer registry stage data are crucial to inform health service planning and to monitor variations in cancer outcomes. However, incomplete stage information is a major concern due to potential biases this introduces. This thesis examined the reasons why a large proportion of prostate cancer cases are recorded as “unknown” stage in the New South Wales (NSW) Cancer Registry (NSWCR) and validated the multiple imputation (MI) method for dealing with “unknown” stage data. NSW is the most populous state in Australia, with almost one third of the total national p

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34

Maya-Pineda, Héctor Rubén. "Sensitization of prostate cancer cells to cytotoxic drugs induced by the small adenoviral E1A12S protein through multiple cell death/signalling pathways." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8482.

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Replication-selective oncolytic adenoviruses represent a promising anticancer approach with proven efficacy in cancer cell lines and tumour xenografts in vivo. Anti-tumour efficacy, both in preclinical studies and clinical trials, was significantly improved in combination with chemotherapeutics in numerous cancers, including prostate cancer. It has been established that expression of the viral E1A gene is essential for the enhancement of cell killing in combination with cytotoxic drugs. The overall goal of this project is to identify specific E1A gene regions involved in the sensitization to t

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Sweeney, Katrina Gabrielle. "Constitutive expression of the AR corepressor, Hey1, from a nonreplicating adenovirus, sensitises prostate cancer cells to chemotherapeutic agents through multiple pathways." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8469.

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Androgen receptor (AR) cell signalling is active in most castration-resistant prostate cancer (PCa) tumours and suppression is hypothesized to impede cell proliferation. Hey1, a corepressor of AR is being investigated as a therapeutic transgene for late-stage PCa. A replication-defective recombinant adenovirus deleted for E1 and E3 and expressing Hey1 under a CMV promoter was constructed (Ad5Hey1). A dual luciferase reporter system demonstrated that Ad5Hey1 repressed AR activity in a dose dependent manner in miboleronestimulated 22Rv1 cells. Ad5Hey1 was cytotoxic in both AR-positive 22Rv1 and

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36

Hawkins, William Tressel II. "Combinatorial Modulation of Multiple Signaling Pathways to Gain Therapeutic Response in Breast and Prostate Cell Carcinomas." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/1043.

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Our laboratory is primarily interested in novel pharmacological intervention of cell proliferation and survival pathways expressed in various types of cancer. These cyto-protective pathways can be activated in response to growth factor stimulation, toxic insult and radiation. In our studies, we utilized novel drug combinations with and without radiation to enhance breast & prostate tumor cell death both in vitro and in vivo. Previous studies from our group have shown that UCN-01 and MEK1/2 inhibitors interact to cause tumor cell death in transformed cell lines in vitro. We extended this observ

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Cruard, Jonathan. "Le Myélome Multiple et son environnement immunitaire à l’échelle de la cellule unique." Electronic Thesis or Diss., Nantes Université, 2023. http://www.theses.fr/2023NANU1033.

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Le Myélome Multiple (MM) est un cancer hématologique dont la cellule tumorale dérive du plasmocyte à longue durée de vie. Cette pathologie est caractérisée par une forte hétérogénéité à divers niveaux. Cette hétérogénéité comprend des altérations intrinsèques et extrinsèques aux tumeurs, lesquelles ont un impact sur le pronostic des patients et leurs réponses aux traitements. L’apparition des technologies de séquençage en cellule unique nous permet aujourd’hui d’explorer de nouveaux aspects de cette diversité. Les travaux présentés ici explorent dans un premier temps la diversité de réponse à

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Janaththani, Panchadsaram. "The role of GWAS identified 5p15 locus in prostate cancer risk and progression." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/125864/1/Panchadsaram_Janaththani_Thesis.pdf.

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Prostate cancer is the second most common cause of cancer death in Australian men. Genetic association studies have identified the 5p15 locus to be associated with prostate cancer risk. The aim of this project is to study the functional role of the genes - IRX4 and IRX4lncRNA at the 5p15 locus in prostate cancer pathogenesis. This study showed that IRX4 modulates the androgen receptor (AR) transcriptome by interacting with the AR co-factor, FOXA1. In addition, IRX4lncRNA was shown to promote prostate cancer cell proliferation and migration. The androgen responsiveness of IRX4 and IRX4lncRNA wa

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Morisot, Adeline. "Méthodes d’analyse de survie, valeurs manquantes et fractions attribuables temps dépendantes : application aux décès par cancer de la prostate." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTT010/document.

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Le terme analyse de survie fait référence aux méthodes utilisées pour modéliser le temps d'apparition d'un ou plusieurs événements en tenant compte de la censure. L'événement d’intérêt peut être l'apparition, la récidive d'une maladie, ou le décès. Les causes de décès peuvent présenter des valeurs absentes, une situation qui peut être modélisée par des méthodes d’imputation. Dans la première partie de cette thèse nous avons passer en revue les méthodes de gestion des données manquantes. Puis nous avons détaillé les procédures qui permettent une imputation multiple des causes de décès. Nous avo

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Puyade, Mathieu. "Parcours de soins des patients atteints d'hémopathies malignes en Poitou-Charentes." Thesis, Poitiers, 2017. http://www.theses.fr/2017POIT1407/document.

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La réduction des inégalités d'accès aux soins a toujours été un axe majeur des politiques de lutte contre le cancer. Alors qu'il existe de nombreuses études en cancérologie solide, peu d'études avec une méthodologie correcte existent en onco-hématologie, notamment chez les patients atteints de Myélome Multiple (MM). Cette maladie a vu son pronostic transformé par l'arrivée de nouvelles thérapeutiques dont l'usage a été rapidement intégré dans les recommandations de la Société Française d'Hématologie. L'objectif de travail intitulé Parcours de Soins des patients atteints d'hémopathie maligne en

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Pliuskys, Laurynas. "Epigenetic regulation of the myeloid cell lineage." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:f4ee6659-ce0b-4730-ae5b-95c141f82e10.

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The myeloid cell lineage is a fundamental element of the immune system and it can give rise to a diverse set of terminally differentiated cells, such as macrophages or osteoclasts among many others. Mutations or misregulation of gene expression may lead to severe clinical conditions, such as arthritis, osteoporosis or cancers. Epigenetics, the regulation of gene expression and chromatin remodelling, is implicated in cell differentiation, function and disease, and hence it is a promising new area to explore in order to explain underlying cellular mechanisms. Firstly, human macrophage subtypes w

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Lemaitre, Léa. "Caractérisations phénotypiques et fonctionnelles des cellules stromales mésenchymateuses au cours du traitement du myélome multiple." Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30279.

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Le myélome multiple (MM) est une hémopathie caractérisée par l'accumulation de plasmocytes (PC) malins dans la moelle osseuse pouvant occasionner entre autres des lésions ostéolytiques. Il s'agit d'une maladie extrêmement hétérogène, tant au niveau de la présentation clinique, de la réponse aux traitements, de la survie globale, que sur le plan biologique. L'hypothèse actuelle est que cette hétérogénéité est non seulement due à l'énorme variabilité moléculaire présente au sein des cellules tumorales mais également au microenvironnement des PC tumoraux. Dans ce microenvironnement nous nous inté

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Seigne, Christelle. "Étude des fonctions biologiques et oncosuppressives du gène de prédisposition aux Néoplasies Endocriniennes Multiples de type 1 dans les tissus hormono-dépendants chez la souris." Phd thesis, Université Claude Bernard - Lyon I, 2009. http://tel.archives-ouvertes.fr/tel-00877511.

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Les mutations du gène MEN1 prédisposent au syndrome des Néoplasies Endocriniennes Multiples de type 1 (NEM1), caractérisé par des tumeurs endocrines multiples. Les souris hétérozygotes pour Men1 développent des tumeurs similaires, ainsi que des cancers de la prostate et des glandes mammaires, avec une incidence faible. J'ai pu montrer que l'expression de la protéine menin, codée par ce gène, est totalement inactivée dans les carcinomes prostatiques développés chez ces souris et est associée à une dérégulation de l'expression du récepteur aux androgènes et une inactivation de l'inhibiteur des C

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Duberg, Ann-Sofi. "Hepatitis C virus infection a nationwide study of associated morbidity and mortality /." Doctoral thesis, Örebro : Örebro universitet, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-7835.

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Shiryaeva, Liudmila. "Proteomics and metabolomics in biological and medical applications." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-43520.

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Biological processes in living organisms consist of a vast number of different molecular networks and interactions, which are complex and often hidden from our understanding. This work is focused on recovery of such details for two quite distant examples: acclimation to extreme freezing tolerance in Siberian spruce (Picea obovata) and detection of proteins associated with prostate cancer. The first biological system in the study, upon P. obovata, is interesting by this species ability to adapt and sustain extremely low temperatures, such as -60⁰C or below. Despite decades of investigations, th

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Tran, Xuan Quang. "Les modèles de régression dynamique et leurs applications en analyse de survie et fiabilité." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0147/document.

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Cette thèse a été conçu pour explorer les modèles dynamiques de régression, d’évaluer les inférences statistiques pour l’analyse des données de survie et de fiabilité. Ces modèles de régression dynamiques que nous avons considérés, y compris le modèle des hasards proportionnels paramétriques et celui de la vie accélérée avec les variables qui peut-être dépendent du temps. Nous avons discuté des problèmes suivants dans cette thèse.Nous avons présenté tout d’abord une statistique de test du chi-deux généraliséeY2nquiest adaptative pour les données de survie et fiabilité en présence de trois cas,

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Swift, Brenna. "Natural Killer Cell Line Therapy in Multiple Myeloma." Thesis, 2011. http://hdl.handle.net/1807/31456.

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Multiple myeloma (MM) is an incurable plasma cell malignancy. NK cells have demonstrated anti-MM activity in allogeneic transplants and donor lymphocyte infusions, and may provide a more effective therapy for MM. This work demonstrates cytotoxicity of NK-92 and KHYG-1 against MM cells in chromium release and flow cytometry cytotoxicity assays. At a 10:1 effector to target ratio, the cytotoxicity of NK cell lines against MM cells is 50-90%. Blocking NKp30 significantly reduces the cytotoxicity of NK-92 and KHYG-1, while blocking NKG2D and DNAM-1 only reduces the cytotoxicity of NK-92. Notably,

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"Differential expression and roles of miR-1246 and miR-1290 in multiple myeloma cancer stem cell-like subpopulation." 2013. http://library.cuhk.edu.hk/record=b5884388.

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Cheung, Hing Yau Coty.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2013.<br>Includes bibliographical references (leaves 111-132).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstracts also in Chinese.

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LIBERATI, SONIA. "The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2." Doctoral thesis, 2014. http://hdl.handle.net/11573/917630.

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Multiple myeloma (MM) is a plasma cell (PC) malignancy characterised by the accumulation of a monoclonal PC population in the bone marrow (BM). Cannabidiol (CBD) is a non-psychoactive cannabinoid with antitumoural activities, and the transient receptor potential vanilloid type-2 (TRPV2) channel has been reported as a potential CBD receptor. TRPV2 activation by CBD decreases proliferation and increases susceptibility to drug-induced cell death in human cancer cells. However, no functional role has been ascribed to CBD and TRPV2 in MM. In this study, we identified the presence of heterogeneous C

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Carson, Jonathan Paul. "Multiple AKT/PKB-independent survival signaling pathways inhibit apoptosis in LNCaP prostate cancer cells /." 2002. http://wwwlib.umi.com/dissertations/fullcit/3038989.

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