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Dissertations / Theses on the topic 'Prostate cancer survival'

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Published: 4 June 2021

Last updated: 18 February 2022

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1

Grönberg, Henrik. "Prostate cancer : epidemiological studies." Doctoral thesis, Umeå universitet, Onkologi, 1995. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96894.

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Prostate cancer is a large and increasing medical problem both in Sweden and in the rest of the developed world, with about 300.000 new cases diagnosed world wide annually. Despite the high incidence of this disease, little is known about the aetiology of prostate cancer. The aim of this study was to try to understand more about the natural history and to find possible a etiological risk factors for this tumour. In a population based study of prostate cancer cases in northern Sweden it was found that the large increase in prostate cancer during the last two decades was mainly caused by well (G

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2

Kim, Daniel Jae. "A study of premorbid diet and prostate cancer survival." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0001/MQ40715.pdf.

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3

Sridhar, Gayathri. "Meta-analysis: Racial Disparities in Prostate Cancer Survival and Case-Control Study: Association between Family History of Cancers, Obesity and Prostate Cancer." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1758.

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This is a compilation of 3 abstracts for the three manuscripts included in this dissertation. I. Meta-Analysis: Racial Disparities in Prostate Cancer Survival: Prostate cancer is the second leading cause of cancer-related mortality in men. Previous studies have drawn inconsistent conclusions on racial differences in prostate cancer survival. This meta-analysis was conducted to investigate the relationship between race and survival from prostate cancer. A systematic review of published articles from 1968 to 2007 assessing survival from prostate cancer among African American and White men was co

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4

Choucair, Khalil. "The clinical implications of the survival pathway in prostate cancer." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110572.

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Prostate Cancer (PCa) is the second leading cause of cancer death in North Americanmen. The heterogeneity of the disease, along with the imperfection of the current prognostic determinants is a challenge to physicians who are unable to discriminate indolent cancers from those that will become life-threatening. Previous work has identified 3 molecular subtypes of PCa that correlated with clinical behaviour, and found the PI/AKT pathway genes to be up-regulated in metastatic samples compared to primary ones. Copy number alteration analysis on this group of patients showed frequent 16p13(PDPK1) g

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5

Klaff, Rami. "Disease-Specific Survival in Prostate Cancer Patients : Results from the Scandinavian Prostate Cancer Group (SPCG) Trial No. 5 and Regional Cancer Register Data." Doctoral thesis, Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-132385.

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Introduction Prostate cancer (PCa) is the most common cancer among men in Sweden. The clinical course varies considerably, which makes it difficult to predict the prognosis in the individual case. In order to explore the early as well as the late course of the disease, large study groups and population-based cohorts are necessary. Aims To explore factors that influence the long-term outcome of men with low-risk tumours in a population-based register, to predict the long-term course, and to assess the mortality rate for men with prostate cancer (Paper I) To analyse long-term outcome and to inve

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6

Kaponen, Martina. "Prediction of survival time of prostate cancer patients using Cox regression." Thesis, Uppsala universitet, Tillämpad matematik och statistik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-354482.

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7

Brown-Williams, Salome Elizabeth. "Brachytherapy and External Beam Radiation and Survival of Jamaicans With Prostate Cancer." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/4044.

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Jamaican males are a high-risk population for aggressive prostate cancer (PrCa) due to genetic influences, and identifying empirical data on treatments, which provide survival benefits is a prime challenge for clinicians who manage Jamaican PrCa patients. Thus, the purpose of this investigation was to elucidate treatment effects of brachytherapy and ERBT in the survival of a Jamaican PrCa cohort. Differences in survival outcomes of brachytherapy and ERBT treated Jamaican, and White U.S.-born PrCa patients with localized PrCa were compared. The mechanism of radiation programmed cell death in Pr

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8

Christiansson, Alexander. "Classication of survival data by comparison of survival functions : an application to prostate cancer registry data." Thesis, Uppsala universitet, Tillämpad matematik och statistik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-420703.

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9

Robinson, David. "Prediction of survival in prostate cancer : aspects on localised, locally advanced and metastatic disease." Doctoral thesis, Linköping : Department of Clinical and Experimental Medicine, Linköping University, 2008. http://www.bibl.liu.se/liupubl/disp/disp2008/med1073s.pdf.

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10

Faysal, Joanne M. "The Effects of Hypoxia with Concomitant Acidosis on Prostate Cancer Cell Survival." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_theses/69.

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Prostate cancer is the second most common cancer among men in the United States. While treatments for prostate cancer exist, none are curative. As a solid tumor, prostate cancer can grow beyond the diffusion limits of oxygen, thereby resulting in a hypoxic environment. While hypoxia can cause death to a variety of cell types, tumor cells can develop resistance to hypoxia and survive under minimal oxygen conditions. Hypoxia in tumor cells has also been associated with poor prognosis, increased metastasis, and decreased efficacy of chemotherapy. BNIP3, a BH-3 only proapoptotic Bcl-2 family

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11

Stewart, Grant Duncan. "Novel survival factors and approaches to the treatment of hypoxic prostate cancer." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/4390.

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Tumour hypoxia has been demonstrated to cause development of an aggressive tumour phenotype and is associated with increased patient mortality and poorer response to treatments such as chemotherapy and radiotherapy. Previous studies have established that hypoxia exists within a nidus of prostate cancer. Based on the importance of the tumour microenvironment, especially hypoxia, in prostate cancer, the major aims of this thesis were to establish: (a) the role of a novel putative survival factor, dermcidin, in prostate cancer survival under hypoxia/oxidative stress; and (b) the effect of nitric

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12

Chan, Yiu Ming. "Statistical Analysis and Modeling of Prostate Cancer." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4806.

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The objective of the present study is to address some important questions related to prostate cancer treatments and survivorship among White and African American men. It is commonly understood that the risk of developing prostate cancer is higher in African American men than the other races. However, using parametric analysis, this study demonstrates that this perception is a "myth" not a "reality". The study further identifies the existence of racial/ethnic disparities by comparing the average mean tumor size, the median of survival time, and the survival function between White and African A

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13

Törnblom, Magnus. "The diagnostic performance of prostate-specific antigen (PSA) in early detection of prostate cancer : considerations of sensitivity, specificity, lead-time and survival /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-660-X/.

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14

Win, Hla Yee. "Role of protein kinase C-iota in prostate cancer." [Tampa, Fla.] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002322.

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15

Bonsu, Nana Osei Mensa. "Age Dependent Analysis and Modeling of Prostate Cancer Data." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4867.

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Growth rate of prostate cancer tumor is an important aspect of understanding the natural history of prostate cancer. Using real prostate cancer data from the SEER database with tumor size as a response variable, we have clustered the cancerous tumor sizes into age groups to enhance its analytical behavior. The rate of change of the response variable as a function of age is given for each cluster. Residual analysis attests to the quality of the analytical model and the subject estimates. In addition, we have identified the probability distribution that characterize the behavior of the response

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16

Ekman, Maria. "The role of Smad7 and TRAF6 in Prostate Cancer Cell Invasion, Migration and Survival." Doctoral thesis, Uppsala universitet, Ludwiginstitutet för cancerforskning, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-159150.

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Transforming growth factor (TGF) β is a tumor suppressor during early tumor development, by inhibiting proliferation and inducing apoptosis. At later stages of cancer, it becomes a tumor promoter, and promotes tumor cell migration and invasion. TGFβ signals via its type II and type I receptors to several downstream signaling pathways. In the present work we have focused on the TRAF6 (tumor necrosis factor receptor-associated factor 6)/ TAK1 (TGFβ activated kinase 1) signaling pathway and the Smad7-dependent activation of p38 in prostate carcinoma cells (PC3U). We found that TGFβ-induced activa

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17

Armstrong, Chris. "Inhibition of treatment-induced cell survival signalling enhances radiosensitivity of PTEN-deficient prostate cancer." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680869.

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Loss of the tumour suppressor PTEN is a common feature of prostate cancer (PCa) and has recently been identified as a prognostic factor for patient relapse following radiotherapy. Published studies in our laboratory have identified CXCL8 signalling as a mediator of PTEN-depleted disease progression and therapeutic resistance. Therefore, experiments were designed to determine whether ionising radiation (IR) could selectively induce CXCL8 signalling in PTEN-deficient cells. Furthermore, we aimed to determine whether therapeutic targeting of the CXCL8 pathway could enhance PCa cell radiosensitivi

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18

Häggström, Christel. "Metabolic factors and risk of prostate, kidney, and bladder cancer." Doctoral thesis, Umeå universitet, Urologi och andrologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-83947.

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Background: Prostate cancer is the most common cancer in Sweden with around 10,000 new cases every year. Kidney and bladder cancer are less common with 1,000 and 2,000 new cases annually, respectively. The incidence of these cancer sites is higher in developed, than in developing countries, suggesting an association between lifestyle and cancer risk. The aims of this thesis were to investigate body mass index (BMI), blood pressure, and blood levels of glucose, total cholesterol, and triglycerides as risk factors for prostate, kidney, and bladder cancer. Furthermore, we aimed at assess probabil

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19

Crnalic, Sead. "Metastatic spinal cord compression in prostate cancer : clinical and morphological studies." Doctoral thesis, Umeå universitet, Ortopedi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-54461.

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Background: Bone metastases occur in most patients with advanced hormone-refractory prostate cancer causing pain, pathologic fractures, and spinal cord compression. Few studies specifically address surgical treatment of metastatic spinal cord compression (MSCC) in prostate cancer. Criteria for identifying patients who may benefit from surgery are poorly defined. Most of the current knowledge regarding tumor biology in prostate cancer is based on studies of primary tumors or soft tissue metastases. The mechanisms regulating growth of bone metastases are not fully established. Aims: a) to evalua

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20

Andrén, Ove. "Natural history and prognostic factors in localized prostate cancer." Doctoral thesis, Örebro University, Academy of Health Science, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-2109.

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<p>The natural history of localized prostate cancer is not fully understood. In most patients the tumor will never progress to a lethal disease, while a subset of patients will ultimately die of the disease. Efficient tools to separate indolent from lethal disease is currently lacking which means that many patients will be offered treatment without any benefit, but still be at risk of experiencing treatment related side effects.</p><p>The aims of these studies were to get more insight into the natural history of untreated localized prostate cancer, to assess the prognostic value of established

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21

Shafique, Kashif. "Analysis of the incidence and patient survival for prostate cancer in the West of Scotland." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3631/.

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Prostate cancer has emerged as the most frequently diagnosed cancer, except for non-melanoma skin cancer, among men in many Western countries in the last decade. In the United Kingdom (UK), prostate cancer accounts for nearly a quarter of all new male cancer diagnoses. Increasing age and some genetic and ethnic risk factors have been identified but few modifiable risk factors are known. The introduction of Prostate Specific Antigen (PSA) testing has increased the detection of previously undiagnosed disease but its contribution to the observed increases in prostate cancer incidence is not clear

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22

Šimonková, Karolína. "Porovnání účinnosti vybraných metod léčení rakoviny prostaty a prsu pomocí analýzy přežití." Master's thesis, Vysoká škola ekonomická v Praze, 2017. http://www.nusl.cz/ntk/nusl-359539.

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This diploma thesis deals with various ways of treatment of selected oncological diseases and the effectiveness of treatment methods and evaluation of the influence of various factors influencing the survival of patients. The activity of individual healing processes is evaluated by survival analysis. The subjects of the study are patients with breast, lung and prostate cancer. The survival analysis considers the sex of the patient, the age and stage of his illness, and other factors to avoid distorted results. The aim of the work is to find out the effects of selected therapeutic procedures on

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23

Wahlgren, Thomas. "High dose rate brachytherapy boost for localized prostate cancer : clinical and patient-reported outcomes/." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-931-9/.

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24

Zhang, Xiaomeng. "Significance and molecular basis of Id-1 in regulation of cancer cell survival and invasion." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39325477.

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25

Hakenberg, Oliver W., Michael Fröhner, and Manfred P. Wirth. "Treatment of Locally Advanced Prostate Cancer – The Case for Radical Prostatectomy." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-133798.

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The treatment of clinically locally advanced prostate carcinoma (stage cT3) remains controversial. One of the main reasons for this controversy results from the substantial staging error attached to the clinical diagnosis cT3 with overstaged T2 tumors and understaged node-positive cases. Treatment options in this situation include radical prostatectomy, external beam radiotherapy, immediate or delayed androgen deprivation treatment and the so-called ‘watchful waiting’. Acceptable and often surprisingly good tumor-specific survival rates have been reported for radical prostatectomy in pT3 serie

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26

Soori, Mehrnoosh. "Neuroendocrine differentiation of prostate cancer cells a survival mechanism during early stages of metastatic colonization of bone /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 105 p, 2009. http://proquest.umi.com/pqdweb?did=1654490661&sid=6&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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27

Hakenberg, Oliver W., Michael Fröhner, and Manfred P. Wirth. "Treatment of Locally Advanced Prostate Cancer – The Case for Radical Prostatectomy." Karger, 2006. https://tud.qucosa.de/id/qucosa%3A27536.

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The treatment of clinically locally advanced prostate carcinoma (stage cT3) remains controversial. One of the main reasons for this controversy results from the substantial staging error attached to the clinical diagnosis cT3 with overstaged T2 tumors and understaged node-positive cases. Treatment options in this situation include radical prostatectomy, external beam radiotherapy, immediate or delayed androgen deprivation treatment and the so-called ‘watchful waiting’. Acceptable and often surprisingly good tumor-specific survival rates have been reported for radical prostatectomy in pT3 serie

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28

Zhang, Xiaomeng, and 張效萌. "Significance and molecular basis of Id-1 in regulation of cancer cell survival and invasion." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39325477.

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29

Frendl, Daniel M. "Predicting Other Cause Mortality Risk for Older Men with Localized Prostate Cancer: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/772.

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Background: Overtreatment of localized prostate cancer (PCa) is a concern as many men die of other causes prior to experiencing a treatment benefit. This dissertation characterizes the need for assessing other cause mortality (OCM) risk in older men with PCa and informs efforts to identify patients most likely to benefit from definitive PCa treatment. Methods: Using the linked Surveillance Epidemiology and End Results-Medicare Health Outcomes Survey database, 2,931 men (mean age=75) newly diagnosed with clinical stage T1a-T3a PCa from 1998-2009 were identified. Survival analysis methods were u

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30

Li, Danbin. "Bone stromal production of insulin-like growth factor binding protein 5 promotes growth and survival of prostate cancer." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31887.

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Prostate cancer (PCa) is the most common cancer among Canadian men and is continuing to be the third-leading cause of male cancer death in Canada. PCa is initially androgen-dependent. Some patients developed metastasis at diagnosis, and are treated by androgen withdrawal therapy. The majority of patients will respond, resulting in tumor growth arrest. However, PCa eventually progresses to androgen-independence and no effective treatment is available. Stromal-epithelial interaction is critical to PCa survival and proliferation. The bone metastasis in PCa indicated compatibility between bone str

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31

Morisot, Adeline. "Méthodes d’analyse de survie, valeurs manquantes et fractions attribuables temps dépendantes : application aux décès par cancer de la prostate." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTT010/document.

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Le terme analyse de survie fait référence aux méthodes utilisées pour modéliser le temps d'apparition d'un ou plusieurs événements en tenant compte de la censure. L'événement d’intérêt peut être l'apparition, la récidive d'une maladie, ou le décès. Les causes de décès peuvent présenter des valeurs absentes, une situation qui peut être modélisée par des méthodes d’imputation. Dans la première partie de cette thèse nous avons passer en revue les méthodes de gestion des données manquantes. Puis nous avons détaillé les procédures qui permettent une imputation multiple des causes de décès. Nous avo

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32

Sandblom, Gabriel. "Diagnosis, management, quality of life, and long-term survival in prostate cancer patients : a study based on national, regional, and local cancer registry data in Sweden /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med664s.pdf.

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33

Gao, Shuai. "The Pro-Survival Functions of Soluble Guanylyl Cyclase Alpha-1 (sGCa1) and Zinc Finger Protein 280B (ZNF280B) in Prostate Cancer." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1373307941.

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34

Josefsson, Andreas. "Prognostic markers in prostate cancer : studies of a watchful waiting cohort with long follow up." Doctoral thesis, Umeå universitet, Patologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50722.

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Background: Prostate Cancer (PC) is a common and highly variable disease. Using current diagnostic methods, the prostate specific antigen (PSA) blood test and histological grading of prostate tissue needle biopsies, it is often difficult to evaluate whether the patient has a PC that requires active treatment or not. The absolute majority of all 10,000 cases of PCs diagnosed annually in Sweden have tumours graded as Gleason score (GS) 6-7 and a PSA value in blood below 10. Many of these are harmless and can be left without active treatment and hence spared problematic post-therapy side-effects,

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35

Fröhner, Michael, Albrecht Scholz, Rainer Koch, Oliver W. Hakenberg, Gustavo B. Baretton, and Manfred P. Wirth. "Competing Mortality Contributes to Excess Mortality in Patients with Poor-Risk Lymph Node-Positive Prostate Cancer Treated with Radical Prostatectomy." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-133747.

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Background: Factors predicting survival in men with lymph node-positive prostate cancer are still poorly defined. Patients and Methods: 193 prostate cancer patients with histopathologically proven lymph node involvement with a median follow-up of 7.3 years were studied. 94% of patients received immediate hormonal therapy. Kaplan-Meier curves were calculated to evaluate overall survival rates and compared with the log-rank test. Cumulative disease-specific and competing mortality rates were calculated by competing risk analysis and compared with the Pepe-Mori test. Cox proportional hazard model

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36

Fröhner, Michael, Albrecht Scholz, Rainer Koch, Oliver W. Hakenberg, Gustavo B. Baretton, and Manfred P. Wirth. "Competing Mortality Contributes to Excess Mortality in Patients with Poor-Risk Lymph Node-Positive Prostate Cancer Treated with Radical Prostatectomy." Karger, 2012. https://tud.qucosa.de/id/qucosa%3A27531.

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Background: Factors predicting survival in men with lymph node-positive prostate cancer are still poorly defined. Patients and Methods: 193 prostate cancer patients with histopathologically proven lymph node involvement with a median follow-up of 7.3 years were studied. 94% of patients received immediate hormonal therapy. Kaplan-Meier curves were calculated to evaluate overall survival rates and compared with the log-rank test. Cumulative disease-specific and competing mortality rates were calculated by competing risk analysis and compared with the Pepe-Mori test. Cox proportional hazard mode

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37

Low, Christopher Gah-Mun. "The role of BIRC6, a member of the inhibitor of apoptosis protein (IAP) family, in the survival of human prostate cancer cells." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/29564.

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Prostate cancer is the most commonly diagnosed cancer and third leading cause of cancer deaths in Canadian men. Prostate cancers typically begin as androgen-dependent tumours susceptible to growth arrest/apoptosis induced by ablation of androgens. Although initially effective, androgen ablation frequently leads to the development of castration-resistant (androgen-independent) prostate cancer, which is generally also resistant to other available treatments. Development of castration-resistant prostate cancer is characteristically associated with marked increases in resistance to apoptosis. BIRC

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38

Shomler, Marsh Danielle. "Prostate Cancer: A Study of Dyadic Communication and Quality of Life for Survivor and Caregiver After Diagnosis." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1617107791287794.

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Williams, Faustine, Kellie R. Imm, Graham A. Colditz, et al. "Physician Role in Physical Activity for African-American Males Undergoing Radical Prostatectomy for Prostate Cancer." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/64.

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Purpose Physical activity is recognized as a complementary therapy to improve physical and physiological functions among prostate cancer survivors. Little is known about communication between health providers and African-American prostate cancer patients, a high risk population, regarding the health benefits of regular physical activity on their prognosis and recovery. This study explores African-American prostate cancer survivors’ experiences with physical activity prescription from their physicians. Methods Three focus group interviews were conducted with 12 African-American prostate cancer

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40

Xin, Yan. "Suramin as a chemo- and radio-sensitizer preclinical translational studies /." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1144958112.

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Singh, Preetinder Pal Clinical School Prince of Wales Hospital Faculty of Medicine UNSW. "A combination of molecular and traditional chemotherapy: prospects of synergies against cancer." Awarded by:University of New South Wales. Clinical School - Prince of Wales Hospital, 2009. http://handle.unsw.edu.au/1959.4/44564.

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In this study, we have explored the combination of a novel Purine Nucleoside Phosphorylase mediated Gene-Directed Enzyme Prodrug Therapy (PNP-GDEPT) with chemotherapeutics, Taxotere and/or Carboplatin to target prostate and ovarian cancer (PC & OC). PNP converts the prodrug (Fludarabine-phosphate) to a toxic purine, 2-fluoroadenine (2FA) that inhibits RNA/DNA synthesis. Taxotere is active against late stage PC whilst carboplatin is first line therapy for OC. Neither modality is adequately effective. We expect that a combination will target heterogeneity via cytotoxicity to diverse cancer cell

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42

Petitprez, Florent. "Integrated analysis and clinical impact of immune and stromal microenvironments in solid tumors Quantitative analyses of the tumor microenvironment composition and orientation in the era of precision medicine Transcriptomic analysis of the tumor microenvironment to guide prognosis and immunotherapies Tumor microenvironment quantification tool draws a comprehensive map of the tumor microenvironment of non-hematologic human cancers The mMCP-counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations using gene expression in murine samples Immune sub-classes in sarcoma predict survival and immunotherapy response Intra-tumoral tertiary lymphoid structures are associated with a low risk of hepatocellular carcinoma early recurrence Association of IL-36γ with tertiary lymphoid structures and inflammatory immune infiltrates in human colorectal cancer Immune-based identification of cancer patients at high risk of progression Tumor-infiltrating and peripheral blood T-cell immunophenotypes predict early relapse in localized clear cell renal cell carcinoma PD-L1 expression and CD8+ T-cell infiltrate are associated with clinical progression in patients with node-positive prostate cancer Intratumoral classical complement pathway activation promotes cancer progression". Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB104.

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Les tumeurs sont composées de cellules malignes et d'une grande variété de cellules non-tumorales, en particulier des cellules immunitaires qui forment le micro-environnement tumoral (MET). Il a été démontré que la composition du MET était associée au devenir clinique des patients, en termes de survie et de réponses thérapeutiques. Avec le développement récent des immunothérapies qui ciblent des éléments spécifiques du MET, l'immunité anti-tumorale a soulevé un intérêt majeur. Plusieurs méthodologies ont été mises au point afin d'étudier la composition du MET, avec une précision toujours plus

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Kao, Hsiao-Han, and 高筱涵. "Effects of Valproic Acid on Androgen Receptor and Prostate Cancer Cell Survival." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/65308469285846845472.

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碩士<br>國立中興大學<br>生命科學系所<br>105<br>Valproic acid (VPA) is an established drug in the long-term therapy of epilepsy. Because of its HDACs inhibition ability, VPA is also associated with anti-cancer activity. Clinical analysis shows that the patients who were treated with VPA may increase serum androgen concentrations. This phenomenon is similar to many non-steroidal anti-androgen drugs. The most important hormone to the prostate gland is androgen. Binding of androgen to androgen receptor (AR) induces dissociation from HSP (heat shock protein) and receptor phosphorylation. The AR dimerizes and ent

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Wang, Hsin-Yi, and 王心怡. "Inhibitory effects of Re-188 labeled Herceptin on prostate cancer cell survival: a possible radioimmunotherapy to prostate carcinoma." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/n48xpz.

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博士<br>國立中興大學<br>生命科學系所<br>101<br>Background: Advanced or metastatic prostate cancers tend to turn into castration-resistant cancers after hormonal therapy. Most of these cases are characterized by elevated HER2 expression and have poor prognosis. Herceptin (Trastuzumab), a humanized anti-HER2 monoclonal antibody, is widely used for the treatment of patients with HER2-overexpressing breast cancer. However, the application of Herceptin in prostate cancer patients is still controversial. In order to understand whether radioimmunotherapeutic strategy is more effective than immunotherapy by attacki

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Sousa, Susana Patrícia Simões. "The Effect of MCT1 and MCT4 silencing on Prostate Cancer Survival and Aggressiveness." Dissertação, 2013. https://repositorio-aberto.up.pt/handle/10216/70527.

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Sousa, Susana Patrícia Simões. "The Effect of MCT1 and MCT4 silencing on Prostate Cancer Survival and Aggressiveness." Master's thesis, 2013. https://repositorio-aberto.up.pt/handle/10216/70527.

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Carson, Jonathan Paul. "Multiple AKT/PKB-independent survival signaling pathways inhibit apoptosis in LNCaP prostate cancer cells /." 2002. http://wwwlib.umi.com/dissertations/fullcit/3038989.

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Luo, Sheng-Jie, and 羅聖傑. "Inhibition of ADAM9 survival signals enhances anti-tumor effect of radiotherapy in prostate cancer." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/22949184715916482169.

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碩士<br>中國醫藥大學<br>癌症生物學研究所<br>97<br>Introduction: The family of a disintegrin and metalloprotease (ADAM) consists of over 30 members displaying multiple biological functions. Previously tissue array analyses confirmed the increasing of ADAM9 correlated with prostate cancer progression. Several studies demonstrated that stresses, including hypoxia and cell crowding, induced ADAM9 elevation during cancer progression. We further confirmed the ADAM9 expression is driven by the production of reactive oxygen species (ROS). In addition, androgen could induce ADAM9 expression in androgen-dependent but n

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Huang, Sih-Jia, and 黃思嘉. "Effect of Multidisciplinary Team Care on Risk of Recurrence and Survival in Prostate Cancer Patients." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/736fmn.

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Fu, Yu-Ke, and 傅榆格. "Suppressive effect of Caffeic Acid Phenethyl Ester on proliferation and survival of docetaxel-resistant prostate cancer cells." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/t294qm.

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