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Dissertations / Theses on the topic 'Prostate syndrome'

Author: Grafiati
Published: 6 June 2025
Last updated: 2 August 2025

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1

Alhabhbeh, Ammar, Purva Sharma, Mohammad Ali Khan, Koyamangalath Krishnan, and Devapiran Jaishanker. "Adenocarcinoma of Prostate with Small Cell Differentiation Presenting As Refractory Hypokalemia." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/29.

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Prostate cancer is among the most common malignancies in males in the United States and adenocarcinoma accounts for 95% of all malignancies of prostate. Rarely prostate cancer can also present as small cell carcinoma. Pure small cell carcinoma is rare at time of initial diagnosis (<2%) however neuroendocrine differentiation into small cell carcinoma may emerge in men who have had previous treatment with ADT for prostate adenocarcinoma. These tumors, sometimes called treatment-related neuroendocrine prostate cancers or aggressive-variant prostate cancers, are increasingly recognized in the cast
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2

Davis, Seth. "Redefining urological chronic pelvic pain syndrome in men: distancing ourselves from the prostate." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110508.

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Urological Chronic Pelvic Pain Syndrome (UCPPS) was long thought to be the direct result of prostate infection. This unidimensional perspective is not supported by current research suggesting a biopsychosocial perspective. Contemporary views take a multifactorial approach to defining UCPPS, and recognize a heterogeneous presentation of symptoms in men with UCPPS. The present thesis examines and describes this heterogeneity and attempts to differentiate UCPPS subtypes. The first chapter of the thesis is a critical review of the literature examining the prevalence and impact of sexual dysfuncti
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3

Maugham, Michelle Louise. "The Rag1-/- mouse: Establishing links between obesity and prostate cancer." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/126971/1/Michelle_Maugham_Thesis.pdf.

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Obesity and metabolic syndrome are associated with increased risk of advanced prostate cancer, more aggressive high grade disease and increased risk of death from prostate cancer. Androgen targeted therapies can rapidly induce symptoms similar to metabolic syndrome in patients, affecting health and quality of life. The development of therapeutics which could target metabolic dysregulation in addition to cancer growth is urgently needed. This thesis established a new mouse model of metabolic syndrome and assessed components of the ghrelin axis as treatments of prostate cancer. Importantly, an a
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4

McKenzie, Ian Robert. "The role of insulin in advanced prostate cancer." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/50662/1/Ian_McKenzie_Thesis.pdf.

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Advanced prostate cancer is a common and generally incurable disease. Androgen deprivation therapy is used to treat advanced prostate cancer with good benefits to quality of life and regression of disease. Prostate cancer invariably progresses however despite ongoing treatment, to a castrate resistant state. Androgen deprivation is associated with a form of metabolic syndrome, which includes insulin resistance and hyperinsulinaemia. The mitogenic and anti-apoptotic properties of insulin acting through the insulin and hybrid insulin/IGF-1 receptors seem to have positive effects on prostate tumo
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5

Rhee, Handoo V. "Androgen deprivation therapy (ADT), metabolic syndrome and metastatic prostate cancer: In vivo and in vitro assessments of effects of metformin." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/118290/2/Handoo%20Rhee%20Thesis.pdf.

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This thesis describes a translational research approach to identifying a cancer mechanism driven by metabolic syndrome. It examines the impact of androgen deprivation therapy, its association with metabolic syndrome and prostate cancer progression, and the therapeutic and metabolic benefits of adjuvant metformin. The study investigates with a randomized placebo controlled clinical trial, with characterization of the molecular mechanism of metformin in vitro using conditions to mimic physiological hormonal milieu.
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6

Lavalette, Céline. "Rôle des facteurs anthropométriques et métaboliques dans la survenue du cancer de la prostate Abdominal Obesity and Prostate Cancer Risk: Epidemiological Evidence From the EPICAP Study Body Mass Index Trajectories and Prostate Cancer Risk: Results From the EPICAP Study." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASR015.

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L’obésité, le diabète ainsi que le syndrome métabolique ont été associés à la survenue de plusieurs cancers. Néanmoins, le rôle de ces facteurs dans la survenue du cancer de la prostate est encore largement discuté. En effet, de nombreuses études ont montré des résultats divergents quant au rôle de l’obésité mesurée par l’indice de masse corporelle (IMC) et le cancer de la prostate, même si certaines études ont mis en évidence un rôle de l’obésité pour les cancers de la prostate agressifs. En revanche, des associations positives ont été rapportées avec le tour de taille ou le rapport taille/ha
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7

Nesheim, Nils [Verfasser]. "Inflammatory Gene Regulation in Chronic Prostatitis / Chronic Pelvic Pain Syndrome (CP/CPPS) and Prostate Cancer / Nils Martin Nesheim." Gieߟen : Universitätsbibliothek, 2020. http://d-nb.info/1216142742/34.

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8

Nesheim, Nils Martin [Verfasser]. "Inflammatory Gene Regulation in Chronic Prostatitis / Chronic Pelvic Pain Syndrome (CP/CPPS) and Prostate Cancer / Nils Martin Nesheim." Gieߟen : Universitätsbibliothek, 2020. http://d-nb.info/1216142742/34.

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9

Wehbi, Mariam. "Le récepteur du froid TRPM8 orchestre le métabolisme et la sécrétion des lipides par la régulation du SCD1 : implication de la physiologie de la prostate au syndrome métabolique et à l'insuffisance cardiaque." Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10325.

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Le syndrome métabolique (MetS) représente une constellation d'anomalies interconnectées, dont l'obésité, la résistance à l'insuline, la dyslipidémie athérogène et l'hypertension. Tous ces facteurs augmentent le risque de maladies cardiovasculaires et de diabète de type 2. La dysrégulation du métabolisme lipidique et la perte de flexibilité métabolique jouent un rôle central dans la pathogenèse du MetS et de l'insuffisance cardiaque à fraction d'éjection préservée (HFpEF). La stéaroyl CoA désaturase 1 (SCD1), l'enzyme goulot d'étranglement qui convertit les acides gras saturés (AGS) en formes m
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10

Spees, Colleen K. "Dysregulation of p53 Gene Expression in Human Prostate Carcinogenesis and Its Relationship to Angiogenesis." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313523656.

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11

Lubik, Amy Anne. "The role of insulin and IGF2 signalling on metabolic pathways in prostate cancer progression." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/49029/1/Amy_Lubik_Thesis.pdf.

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Prostate cancer (CaP) is the most commonly diagnosed cancer in males in Australia, North America, and Europe. If found early and locally confined, CaP can be treated with radical prostatectomy or radiation therapy; however, 25-40% patients will relapse and go on to advanced disease. The most common therapy in these cases is androgen deprivation therapy (ADT), which suppresses androgen production from the testis. Lack of the testicular androgen supply causes cells of the prostate to undergo apoptosis. However, in some cases the regression initially seen with ADT eventually gives way to a growth
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12

Grundmark, Birgitta. "Prostate Cancer; Metabolic Risk Factors, Drug Utilisation, Adverse Drug Reactions." Doctoral thesis, Uppsala universitet, Institutionen för kirurgiska vetenskaper, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-194297.

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Increased possibilities during the last decades for early detection of prostate cancer have sparked research on preventable or treatable risk factors and on improvements in therapy. Treatments of the disease still entail significant side effects potentially affecting men during the rest of their lives. The studies of the present thesis concern different aspects of prostate cancer from etiological risk factors and factors influencing treatment to an improved methodology for the detection of treatment side effects. Papers I, II, both based in the population based cohort ULSAM (Uppsala Longitudin
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13

Araújo, Liana Maria Tôrres de. "Anestesia para ressecção transuretral de próstata: comparação entre dois períodos no HC-FMRP-USP." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/17/17142/tde-06042009-122239/.

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A Hiperplasia Prostática Benigna (HPB) é a doença benigna mais freqüente na terceira idade. A Ressecção Transuretral (RTU) de próstata constitui-se na técnica operatória mais empregada atualmente para o tratamento da HPB. A anestesia para este procedimento possui características próprias, tornando-se um desafio para o anestesiologista o manejo de suas particularidades. Com o objetivo de avaliar a conduta anestésica, comparando técnicas empregadas, drogas e doses, eventuais complicações e respectivos tratamentos, revisou-se 300 prontuários de pacientes submetidos a RTU de próstata no Hospital d
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14

Mehik, A. (Aare). "Epidemiological and diagnostical aspects of prostatitis." Doctoral thesis, University of Oulu, 2001. http://urn.fi/urn:isbn:9514265068.

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Abstract The principal aim of a population-based cross-sectional survey was to generate information on the lifetime occurrence of prostatitis in Finnish men and their exposure to the disease, and also on the influence of prostatitis-related fears and disturbances on their sexual life. A second aim was to develop and clinically validate a new diagnostic tool for differential diagnosis between the forms of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), especially between patients belonging to categories IIIA and IIIB in the new NIH (National Institutes of Health) clinical classifica
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15

Barrow, Paul. "Hereditary colorectal cancer : registration, screening and prognostic biomarker analysis." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/hereditary-colorectal-cancer-registration-screening-and-prognostic-biomarker-analysis(45d75b71-edc0-4c9f-a381-9ecda92f2fac).html.

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Aims: The purpose of the research was to investigate the benefits of a hereditary colorectal cancer registry in the management of patients and families with Lynch syndrome. In study one, a systematic review was performed to quantify the impact of registration and screening on colorectal cancer (CRC) incidence and mortality, with comparison between familial adenomatous polyposis (FAP) and Lynch syndrome (LS). In study two, a regional Lynch syndrome registry was utilised to evaluate the uptake of predictive testing and colorectal screening among first-degree relatives (FDRs) and investigate nove
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16

Dulary, Eudoxie. "N-glycosylation et pathologies associées : étude de deux acteurs majeurs Man2C1 et Gdt1." Thesis, Lille 1, 2017. http://www.theses.fr/2017LIL10048/document.

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Une altération du processus de N-glycosylation des protéines peut conduire à l’apparition de pathologies comme le cancer ou les "Congenital Disorders of Glycosylation" (CDG). La première partie de mon travail de thèse a porté sur l’étude de l’implication de la Man2C1 dans la cancérogenèse de la prostate. La Man2C1 est une glycosidase impliquée dans le processus ERAD « Endoplasmic reticulum associated degradation ». Nous avons montré le transfert de précurseurs oligosaccharidiques incomplets de type Man9Gn2 et Man5Gn2 sur les protéines, ainsi qu’une diminution de l’antennarisation des N-glycann
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17

Ju, Mingxuan. "Machine Learning for Responsiveness of Medication in Bladder and Prostate Syndromes." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1586449819233263.

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18

Chambó, Renato Caretta [UNESP]. "Efetividade da finasterida no tratamento da síndrome da dor pélvica crônica: revisão sistemática e metanálise." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/91399.

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Made available in DSpace on 2014-06-11T19:25:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-05-09Bitstream added on 2014-06-13T18:53:13Z : No. of bitstreams: 1 chambo_rc_me_botfm.pdf: 605131 bytes, checksum: 81f0a6d5dda1782f51f5b580a20f8761 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A Síndrome da Dor Pélvica Crônica (SDPC) é uma nova categoria na classificação atual das prostatites. A causa da SDPC é desconhecida, a teoria mais aceita é o refluxo intraprostático. Não há estudo que comprove qual o melhor tratamento. A finasterida, uma das drogas
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19

Chambó, Renato Caretta. "Efetividade da finasterida no tratamento da síndrome da dor pélvica crônica : revisão sistemática e metanálise /." Botucatu : [s.n.], 2008. http://hdl.handle.net/11449/91399.

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Resumo: A Síndrome da Dor Pélvica Crônica (SDPC) é uma nova categoria na classificação atual das prostatites. A causa da SDPC é desconhecida, a teoria mais aceita é o refluxo intraprostático. Não há estudo que comprove qual o melhor tratamento. A finasterida, uma das drogas utilizadas para o tratamento, é um antiandrogênio que bloqueia a enzima 5-alfa redutase, diminuindo o tamanho da próstata. A finasterida agiria na SDPC reduzindo o tecido glandular prostático, diminuindo a tensão intraprostática e conseqüentemente o refluxo intraprostático. Avaliar a efetividade e a segurança da finasterida
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20

Bokhobza, Alexandre. "Etude du remodelage des protéines ORAI grâce à l'utilisation de la technique CRISPR/Cas9 et de la microscopie quantitative." Thesis, Université de Lille (2022-....), 2022. https://pepite-depot.univ-lille.fr/LIBRE/EDBSL/2022/2022ULILS100.pdf.

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L’entrée capacitive de calcium (Ca2+), appelée SOCE en anglais (store operated Ca2+ entry) représente une entrée d’ions Ca2+ dans la cellule consécutive à la vidange des stocks calcique réticulaires. Ce processus constitue l’un des mécanismes d’entré majeure de Ca2+ dans les cellules non-excitables. L’importance physiologique de ce processus est soulignée par la gravité des syndromes induits par des mutations des canaux responsables du SOCE : le syndrome sévère d’immunodéficience combinée induit par des mutations de types perte de fonction du SOCE et les syndromes d’agrégation tubulaire myopat
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21

LOTTI, FRANCESCO. "Impact of the metabolic syndrome on reproductive health in males of infertile couples." Doctoral thesis, 2014. http://hdl.handle.net/2158/850825.

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AIM OF THE THESIS Since Metabolic Syndrome (MetS) is essentially based on increased adiposity and it is associated with male hypogonadism, erectile dysfunction, psychological disturbances, and BPH/LUTS, and all these factors might, in different ways, affect reproductive capacity, we investigated their possible correlations with MetS. Hence, we performed two studies. In the first study (study 1) we evaluated possible associations between MetS, semen and hormonal parameters, as well as clinical characteristics, including sexual, ultrasound and psychological characteristics, in a cohort of men
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